Vertex Pharmaceuticals

Senior Principal Scientist Biotransformation page is loaded Senior Principal Scientist Biotransformationlocations: Oxford, United Kingdomtime type: Full timeposted on: Posted 2 Days Agotime left to apply: End Date: February 9, 2026 (21 days left to apply)job requisition id: REQ-27703 Job Description General Summary: Vertex is seeking a highly motivated and experienced Senior Principal Biotransformation Scientist to join our Oxford team. The successful candidate will play a leading role in the delivery of biotransformation and metabolite characterization support to our drug discovery and development projects. The successful candidate will have a deep analytical background in high resolution mass spectrometry and metabolite identification with an established track record for designing, executing and interpreting bespoke biotransformation studies. They will be responsible for the delivery of critical in vitro and in vivo biotransformation knowledge to aid medicinal chemistry design and influence key decisions impacting drug discovery and clinical development. Key Duties and Responsibilities: Provide mass spectrometry and metabolite identification expertise to the DMPK organization, keeping abreast of new scientific developments related to biotransformation science Proactively apply deep biotransformation scientific expertise to design and deliver metabolism studies in line with DMPK and project key deliverables Understand, interpret, and communicate biotransformation data to Project Representatives and key stakeholders to aid medicinal chemistry design and influence key decisions Be able to troubleshoot, problem-solve and define best practice for biotransformation studies Drive innovation by investigating and implementing new analytical technologies and procedures Contribute to the wider global biotransformation strategy to grow biotransformation science at Vertex Create internal and external networks to drive science within their discipline Author study reports Ensure high levels of data integrity and data accessibility Provide training and mentoring to more junior biotransformation colleagues Knowledge and Skills: Proven ability of metabolite characterisation and quantification using high resolution mass spectrometry and state-of-the-art metabolite acquisition and processing software Deep knowledge of biotransformations with extensive proven experience applying this to drug discovery and development programs Good understanding of in vitro and in vivo approaches used to understand biotransformation issues Ability to work in a matrix environment and problem solve with an extensive track record of generating high quality data and reports Excellent communication, interpersonal and team working skills Track record of developing more junior biotransformation scientists Education and Experience: BSc or equivalent in relevant field (PhD desirable) or equivalent relevant working experience. Flex Designation: On-Site Designated Flex Eligibility Status: In this On-Site designated role, you will work five days per week on-site with ad hoc flexibility. Note: The Flex status for this position is subject to Vertex's Policy on Program and may be changed at any time. Company Information Vertex is a global biotechnology company that invests in scientific innovation.Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at

A leading biotechnology company in Oxford is seeking a Senior Principal Scientist Biotransformation to drive biotransformation support for drug discovery. The candidate will leverage expertise in mass spectrometry and metabolite identification to contribute to critical projects. Responsibilities include designing metabolic studies, troubleshooting biotransformation issues, and mentoring junior scientists. A BSc is required and a PhD is desirable. This is an on-site role with a focus on innovation and data integrity.