17 jobs found

Duration: 3-year fixed term About the role: We are seeking a Postdoctoral Scientist to join the newly established Myeloid Cancer Biology group, led by Dr Justin Loke, to investigate how inherited and acquired genetic mutations cooperate to drive acute myeloid leukaemia (AML) and myelodysplastic syndrome (MDS). A key focus of the post are inherited conditions caused by germline mutations that carries a substantial lifetime risk of AML/MDS. How specific combinations of somatic mutations cooperate with these inherited mutations to drive leukaemic transformation remains poorly understood, in large part because existing model systems cannot recreate the complex, multi-mutation genotypes seen in patients. The post holder will use a novel transgenic mouse platform developed by the PI and colleagues, in which Cas12a-mediated genome editing enables simultaneous disruption of up to four genetic loci within single haematopoietic stem and progenitor cells. Using this platform, the post holder will generate and characterise genetically complex murine models of inherited predisposition related MDS/AML, combining in vivo transplantation experiments, flow cytometry and histopathology with single-cell multiome (RNA and ATAC) profiling to define the epigenetic programmes underlying malignant transformation, and to establish proof-of-concept for novel therapeutic vulnerabilities in this and related inherited myeloid malignancy syndromes. This post is supported by a John Goldman Fellowship from Leukaemia UK. The Environment: The Myeloid Cancer Biology group was established in October 2025, and this post offers an early opportunity to help shape a new laboratory's research programme and infrastructure. The post holder will work closely with the Group Leader and benefit from the wider myeloid malignancy and haematology community at the Institute, including collaboration with Professor Tim Somervaille (epigenetic mechanisms in myeloid neoplasia) and Professor Georges Lacaud (RUNX1 biology and haematopoiesis), as well as an established international collaboration on Cas12a genome-editing technology. The Institute's core facilities - including the Genome Editing and Mouse Models Facility, Flow Cytometry, Molecular Biology and Computational Biology Support - provide direct technical support for the in vivo and single cell components of this project. The group is based in the Paterson Building, directly attached to The Christie NHS Foundation Trust, providing a translational research environment with strong links to clinical haematology. About you: You should have, or be near completion of, a PhD in cancer biology, molecular biology, genetics, immunology, haematology or a related field. You will have demonstrable practical experience of mammalian cell culture and core molecular biology techniques, together with a track record of scientific publication or presentation, and the ability to define and solve research questions independently. Prior experience with murine/in vivo models, genome engineering or CRISPR-based approaches, and/or single cell genomic technologies would be a strong advantage, as would a background in haematopoiesis or leukaemia biology - but candidates with strong complementary expertise and a genuine interest in developing these skills are also encouraged to apply. Why choose Cancer Research UK Manchester Institute? The Cancer Research UK Manchester Institute (), an Institute of The University of Manchester (), is a world leading centre for excellence in cancer research. The Institute is core funded by Cancer Research UK (), the largest independent cancer research organisation in the world. In spring 2023 the Institute moved into the new Paterson Building, a £150 million flagship purpose built biomedical research centre directly attached to The Christie NHS Foundation Trust (), in South Manchester. We are partnered with The Christie NHS Foundation Trust, one of the largest cancer treatment centres in Europe. These factors combine to provide an exceptional environment in which to pursue basic, translational and clinical research programmes. Closing date: 18:00, 11 October 2026 Sunday First-round interviews (via Microsoft Teams): 15 and 16 October 2026 Second-round interviews (in person): w/c 26 October 2026

Postdoctoral Fellow (Papayannopoulos Lab) Contract term: This is a full-time, fixed term (4 years) position on Crick terms and conditions of employment. Reporting to: Venizelos Papayannopoulos, Principal Group Leader Salary for this Role: From £47,500 with benefits, subject to skills and experience About us The Francis Crick Institute is Europe's largest biomedical research institute under one roof. Our world-class scientists and staff collaborate on vital research to help prevent, diagnose and treat illnesses such as cancer, heart disease, infectious diseases and neurodegenerative conditions. The Crick is a place for collaboration, innovation and exploration across many disciplines. A space where the brightest minds can pursue big and bold ideas and discover answers to crucial scientific questions. We support them in a dynamic environment which fosters excellence with state-of-the-art infrastructure, cutting-edge facilities, and a creative and curious culture. We've removed traditional boundaries of departments, divisions and disciplines and instead have an open approach that supports every researcher. This gives us the freedom to take risks and carry out high-quality, pioneering research. Creating a space for discovery without boundaries helps us to turn our science into benefits for human health and the economy. About the Papayannopoulos Lab The Papayannopoulos Lab investigates how the innate immune system responds to infection while limiting harmful inflammation. Focusing on fungal and bacterial infections, we study how immune cells such as neutrophils and macrophages coordinate antimicrobial responses, prevent sepsis and regulate inflammatory diseases. Using cutting-edge immunology, cell biology and in vivo disease models, our research aims to uncover new mechanisms that could lead to improved treatments for infections and inflammatory diseases. About the role We are seeking an ambitious Postdoctoral Research Fellow to lead an independent research project investigating how the recognition and processing of PAMPs and DAMPs regulates inflammation and microbial control during fungal and bacterial infections. Working within a collaborative and multidisciplinary research environment, you will design and deliver innovative research using molecular, cellular and in vivo approaches, while contributing to high-impact publications, grant applications and the wider research programme. This ERC-funded position offers an excellent opportunity to establish your independent research profile within a world-leading biomedical research institute. What you'll be doing You will be responsible for: Leading an independent research project focused on innate immune responses during infection. Designing and carrying out experiments using in vitro systems and mouse models of disease. Applying molecular, cellular and biochemical techniques including flow cytometry, CRISPR, microscopy and transcriptomic analysis. Analysing experimental data and publishing findings in leading scientific journals. Presenting research at national and international conferences. Contributing to grant applications and collaborative research initiatives. Mentoring PhD students and collaborating with researchers across the Crick and external partners. About you You will have: Essential (Minimum criteria ) PhD in immunology, infection biology, biochemistry, cell biology or a related discipline, or be in the final stages of PhD submission. Strong knowledge of immunology, biochemistry and cell biology. Experience working with molecular, cellular and mouse models of disease. Evidence of first-author publications or manuscripts submitted for publication. Excellent experimental design, scientific writing, organisational and collaborative working skills. A passion for innovative research and strong drive to publish high-quality science. Desirable Experience in myeloid cell biology or cellular signalling pathways. Experience with advanced biochemical or cellular biology techniques. About Working at the Crick Our values Everyone who works at the Crick has a valuable role to play in advancing the Crick's mission and shaping our culture! We are bold. We make space for creative, dynamic and imaginative ideas and approaches. We're not afraid to do things differently. We are open. We're highly collaborative and interactive, and make sure our activities are visible to the outside world. We are collegial. We show respect for one another, work cooperatively and support the wider community. At the Francis Crick Institute, we believe that diversity and inclusion are essential to driving innovation and scientific discovery. We are committed to creating a workplace where everyone feels valued, respected, and empowered to succeed, regardless of their background, identity, or personal circumstances. We actively encourage applications from individuals of all genders, ethnicities, abilities, and experiences. Weare a Disability Confident: Committedemployer and want to ensure that everyone can apply and be part of our recruitment processes and so we'll make reasonable adjustments if you need them - just let us know when you apply. If you need assistance with applying (i.e., would like to apply by phone or post) please email: . What will you receive? At the Francis Crick Institute, we value our team members and are proud to offer an extensive range of benefits to support their well-being and development: Visas: Applicants for this role will be eligible for sponsorship to work in the UK Generous Leave: 28 days of annual leave, plus three additional days over Christmas and bank holidays. Pension Scheme: Defined contribution pension with employer contributions of up to 16%. Health & Well-being: 24/7 GP consultation services. Occupational health services and mental health support programs. Eye care vouchers and discounted healthcare plans. Work-Life Balance: Back-up care for dependents. Childcare support allowance. Annual leave purchase options. Crick Networks offering diverse groups' support, community and inclusive social events. Perks: Discounted gym memberships, bike-to-work scheme, and shopping discounts. Subsidised on-site restaurant and social spaces for team interaction. Career support: A Post-doc to PI programme and other career development activities Please note you must meet the essential criteria listed within the Role Profile, to have your application reviewed. We reserve the right to withdraw this advert at any given time due to the number of applications received.

Ellison Institute of Technology in Oxford is building a joint experimental computational team focused on creating, training and validating multi-modal biological models. The team will generate perturbation data at scale, build models, and use data to train and validate methods. You will perform genome engineering and design scalable measurement across modalities with automation support. You will join AI scientists and synthetic biologists working together to push biology at scale and translate

The Francis Crick Institute in London is seeking a highly motivated Postdoctoral Fellow for the Nurse Lab. You will lead an independent project studying how Cyclin-Dependent Kinases regulate the cell cycle, with potential focus on CDK activity in G1/S and mitosis, nuclear transport, and chromatin roles. You will work in a collaborative environment, design experiments, analyze results, and contribute to publications while mentoring PhD students when appropriate.

At the Ellison Institute of Technology (EIT), we're on a mission to translate scientific discovery into real world impact. We bring together visionary scientists, technologists, engineers, researchers, educators and innovators to tackle humanity's greatest challenges in four transformative areas: Health, Medical Science & Generative Biology Food Security & Sustainable Agriculture Climate Change & Managing CO Artificial Intelligence & Robotics This is ambitious work - work that demands curiosity, courage, and a relentless drive to make a difference. At EIT, you'll join a community built on excellence, innovation, tenacity, trust, and collaboration, where bold ideas become real-world breakthroughs. Together, we push boundaries, embrace complexity, and create solutions to scale ideas from lab to society. Welcome to the Generative Biology Institute: Led by Founding Director Jason Chin, the Generative Biology Institute (GBI) at the Ellison Institute of Technology is tackling the key challenges in making biology engineerable, and thereby releasing the unrivalled power of biology for the benefit of humanity. The vision of GBI is to lay the foundations for engineering biology, and unlock its potential for good. To achieve this, we must overcome two key challenges. First, we need the ability to write in the natural language of biology, enabling the rapid and scalable synthesis of entire genomes with precision. Second, we must understand what to write - determining which DNA sequences will generate biological systems that perform the desired functions. Addressing these challenges will allow us to harness the full power of biology to create transformative solutions across health, agriculture, clean energy and more. The Generative Biology Institute commenced operations in 2025, occupying newly renovated bespoke space in the Oxford Science Park. The team will later move to a purpose-made facility in the Oxford Science Park, currently under construction. Once complete, this state-of-the-art facility will include more than 40,000 m of research laboratory and office space. It will house over 30 groups and up to 600 employees at scale, focused on solving the two critical challenges in making biology engineerable and applying the solutions to addressing the global challenges encapsulated in EIT's Humane Endeavours. Job Summary We are building a joint experimental computational team focussed on building, training and validating multi-modal biological models. The team will: i) generate experimental perturbation and measurement data at scale, ii) build multi-modal biological models and, iii) use the experimental data they generate to train and validate the multi-modal biological models they build. In this role you will: i) perform experimental genome engineering work to generate genetic variation at scale and/or ii) design and implement scalable biological measurement over one or more modalities. Where appropriate the work will leverage the substantial automation capability within the institute. Your work will be performed under the guidance of Jason Chin. You will be part of a single team composed of AI scientists and synthetic biologists working together. We are looking for colleagues with deep expertise in genome engineering and/or quantitative phenotyping of model bacterial species such as Escherichia coli. The role requires the ability and willingness to work as part of a cross-disciplinary team at the interface of computational and wetlab biology. Our team ethos is based on mutual learning, strong peer-to-peer support, and a deep sense of scientific curiosity and ambition. This is your opportunity to be part of cutting-edge research within an institute dedicated to engineering biology at an unprecedented scale. You will be leveraging GBI's exceptional facilities, sustained funding, and collaborative environment. You will design and execute experiments, contribute to high-impact publications, and play a key role in the training and mentorship of junior researchers and students. Working at the interface of biology, AI, technology, and engineering, you will help shape GBI's vision to reimagine what's possible in biology. Key Responsibilities: Design, execute, and troubleshoot experiments, including the development of novel methodologies and adaptation of existing techniques to new applications. In particular, the successful applicant will utilise genome engineering strategies in the lab to produce a diversity of microbial strains as the source of training and validation data in a high throughput fashion. In addition, they will also design and prototype a range of experimental measurement strategies for characterising these strains at scale. Collaborate with other GBI scientists from other groups expert in synthetic biology, automation, bioinformatics, -omics and machine learning, and AI scientists from the AIR institute, as required. Analyse complex datasets using computational and statistical tools, interpreting results in the context of broader research goals. Contribute intellectually to the research direction by identifying opportunities for innovation and refining research questions. Prepare and publish high-quality scientific papers, reports, presentations, and protocols. Present research at national and international conferences, seminars, and internal meetings. Collaborate with multidisciplinary teams within GBI, EIT, and external partners to advance complementary workstreams. Build and maintain research infrastructure, laboratory capabilities, and cutting-edge technologies. Mentor and support junior researchers, including PhD students and research assistants. Translate research findings into commercial or translational opportunities in alignment with EIT's mission. Identify and pursue opportunities for intellectual property generation and protection.Ensure research activities comply with EIT's policies, legal requirements, and best scientific practice. This list is not exhaustive and the role holder may be required to undertake additional tasks and duties commensurate with the role. Relevant, Skills and Experience: Completed a PhD in a relevant field (e.g., synthetic biology, computational biology and AI, microbial genomics, cell biology, genomics, robotics and automation, metabolomics, and proteomics.). Track record of delivering ambitious research projects to a high standard. Strong track record in research, ideally in molecular biology, synthetic biology, or related fields. Skilled in data analysis and interpretation; experience with genomic analysis, automation, or computational tools desirable. Proven ability to work independently, think creatively, and solve complex experimental problems. Experience publishing in high-impact journals and presenting at international conferences. Excellent organisational skills with the ability to manage multiple concurrent projects. Strong written and verbal communication skills, with experience collaborating in multidisciplinary teams. Capacity to build and sustain productive collaborations internally and externally. Resilience, adaptability, and enthusiasm for working in a fast paced, high growth research environment. Our Benefits: Annual Bonus Travel allowance Enhanced sick pay Pension - Employer contribution 7.5%, minimum employee contribution 5% Life Assurance Income Protection Private Medical Insurance as standard for you, your partner and any dependents. Including hospital Cash Plan Employee discounts Electric car scheme Nursery Salary Sacrifice scheme Cycle to Work Scheme Family Planning Neurodiversity support including advise and assessments Coaching & Therapy services Working Together - What It Involves: You must have the right to work permanently in the UK with a willingness to travel as necessary. In certain cases, we can consider sponsorship, and this will be assessed on a case-by-case basis. You will live in, or within easy commuting distance of, Oxford (or be willing to relocate).

Jobs in Structural Biology and Related Fields Postdoctoral position in AI for Molecular Modelling Department of Computer Science - Brunel University of London Contract Type: Fixed-term until 30/11/2028 The Research Fellow will deliver the computational component of the project through protein structure modelling, molecular docking and detailed analysis of protein-ligand interactions. They will integrate these results with receptor-interaction data generated by the experimental collaborators at the University of Southampton to develop and evaluate artificial intelligence (AI) methods for predicting chemical binding and species sensitivity. Preference will be given to candidates with knowledge and experience of protein molecular modelling, protein-ligand docking, machine learning methods for computational biology, and software development in Python. Closing date for applications: 21st September 2026 Interviews will take place during the week of 12th October 2026 online.

Postdoctoral Fellow - Frohlich Lab In the Crick's Fröhlich F Research Group. Key information Postdoctoral Fellow (Fröhlich Lab) Contract term: This is a full-time, fixed term (4 years) position on Crick terms and conditions of employment. Reporting to: Fabian Fröhlich, Group Leader Salary for this Role: From £47,500 with benefits, subject to skills and experience About us The Francis Crick Institute is Europe's largest biomedical research institute under one roof. Our world-class scientists and staff collaborate on vital research to help prevent, diagnose and treat illnesses such as cancer, heart disease, infectious diseases and neurodegenerative conditions. The Crick is a place for collaboration, innovation and exploration across many disciplines. A space where the brightest minds can pursue big and bold ideas and discover answers to crucial scientific questions. We support them in a dynamic environment which fosters excellence with state-of-the-art infrastructure, cutting-edge facilities, and a creative and curious culture. We've removed traditional boundaries of departments, divisions and disciplines and instead have an open approach that supports every researcher. This gives us the freedom to take risks and carry out high-quality, pioneering research. Creating a space for discovery without boundaries helps us to turn our science into benefits for human health and the economy. About the Fröhlich Lab The Fröhlich Lab combines quantitative biology with scientific machine learning (SciML) to understand how cells respond to perturbations and uncover fundamental principles of cellular behaviour. Bringing together expertise across mathematics, physics, biology, engineering and data science, we integrate mechanistic models, machine learning and high-throughput experiments to study cellular signalling and cell states across scales. About the role We are seeking an ambitious Postdoctoral Fellow to develop the next generation of deep mechanistic models (DMMs; Fabrini & Fröhlich, bioRxiv 2026, doi: 10.64898/2026.07.30.741759) for biological systems. You will lead a computational research project extending DMMSs from population-level to single-cell data, combining neural networks with mechanistic differential equation models to understand signalling differences between individual cells. You will develop open-source computational tools () and apply them to cutting-edge single-cell datasets generated within the lab and from public resources. There is significant scope to shape the project around your interests, including live-cell imaging, flow matching, optimal transport or cell-cycle modelling. This is an exciting opportunity for a computational researcher who wants to develop innovative machine-learning methods while tackling fundamental biological questions within a highly interdisciplinary environment. Click to find out more about the Fröhlich Lab What you'll be doing You will be responsible for: Leading an independent research project in scientific machine learning and mechanistic modelling. Developing deep mechanistic models for single-cell biological data. Building and maintaining reusable, open-source computational tools. Applying new methods to biological datasets and interpreting their biological significance. Collaborating with computational and experimental researchers across the Crick and internationally. Publishing your research and presenting at national and international conferences. Supporting and mentoring graduate students where appropriate. About you You will have: Essential: PhD in mathematics, physics, data science, engineering, systems biology or a related field, or be in the final stages of PhD submission. Strong scientific programming skills in Python. Knowledge of mathematical models of biological systems and numerical methods for differential equations. Experience developing and pursuing independent research ideas. Strong written and verbal scientific communication skills. A collaborative, cross-disciplinary approach and interest in applying computational methods to biological questions. Commitment to reproducible research and open science. Desirable: Experience with machine learning frameworks such as JAX or PyTorch with a focus on single-cell methods such as optimal transport or flow matching Knowledge of cell biology, biochemistry relevant to signalling and cell cycle pathways Experience with modern software development practices or high-performance computing. About Working at the Crick Our values Everyone who works at the Crick has a valuable role to play in advancing the Crick's mission and shaping our culture! We arebold. We make space for creative, dynamic and imaginative ideas and approaches. We're not afraid to do things differently. We areopen. We're highly collaborative and interactive, and make sure our activities are visible to the outside world. We arecollegial. We show respect for one another, work cooperatively and support the wider community. At the Francis Crick Institute, we believe that diversity and inclusion are essential to driving innovation and scientific discovery. We are committed to creating a workplace where everyone feels valued, respected, and empowered to succeed, regardless of their background, identity, or personal circumstances. We actively encourage applications from individuals of all genders, ethnicities, abilities, and experiences. Weare aDisability Confident: Committedemployer and want to ensure that everyone can apply and be part of our recruitment processes and sowe'llmake reasonable adjustments if you need them - just let us know when you apply. If you need assistance with applying (i.e., would like to apply by phone or post)please email: . Find out more about life at the Crick. What will you receive? At the Francis Crick Institute, we value our team members and are proud to offer an extensive range of benefits to support their well-being and development: Visas:Applicants for this role will be eligible for sponsorship to work in the UK Generous Leave: 28 days of annual leave, plus three additional days over Christmas and bank holidays. Pension Scheme: Defined contribution pension with employer contributions of up to 16%. Health & Well-being: 24/7 GP consultation services. Occupational health services and mental health support programs. Eye care vouchers and discounted healthcare plans. Work-Life Balance: Back-up care for dependents. Childcare support allowance. Annual leave purchase options. Crick Networks offering diverse groups' support, community and inclusive social events. Perks: Discounted gym memberships, bike-to-work scheme, and shopping discounts. Subsidised on-site restaurant and social spaces for team interaction. Career support: A Post-doc to PI programme and other career development activities Please note you must meet the essential criteria listed within the Role Profile, to have your application reviewed. We reserve the right to withdraw this advert at any given time due to the number of applications received.

Senior Research Fellow - Digital Pathology & Artificial Intelligence University College London (UCL) invites applications for the position of Senior Research Fellow in Digital Pathology and Artificial Intelligence. This role is based within a world-leading research environment focused on advancing computational medicine, digital health technologies, and AI-driven clinical innovation. The successful candidate will contribute to cutting-edge research at the intersection of digital pathology, machine learning, and computational biomedical sciences. The role involves developing and applying advanced artificial intelligence methods to digital pathology data, including whole-slide imaging, computational image analysis, and multi-modal clinical data integration. The research aims to improve disease diagnosis, prognostic modelling, and precision medicine approaches. The postholder will work closely with multidisciplinary teams of clinicians, data scientists, and biomedical researchers. Responsibilities include designing and implementing AI algorithms, managing and analysing large-scale pathological imaging datasets, contributing to high-impact publications, supporting grant applications, and collaborating on translational research projects. The role may also involve mentoring junior researchers and contributing to strategic research development within the department. This position offers the opportunity to be part of a highly collaborative and internationally recognised research ecosystem at UCL, with strong links to clinical partners and biomedical research institutions. The successful candidate will contribute to advancing AI applications in healthcare and driving innovation in digital pathology research. Eligibility Criteria PhD in Computer Science, Artificial Intelligence, Biomedical Engineering, Bioinformatics, Medical Imaging, or a related discipline Extensive postdoctoral research experience relevant to digital pathology, computational imaging, or AI in healthcare Strong publication record in peer-reviewed journals in relevant fields Demonstrated experience in leading or contributing to advanced research projects Experience appropriate to a senior research or leadership-level research role Strong evidence of interdisciplinary research collaboration, particularly with clinical or biomedical partners Ability to contribute to research strategy and funding applications Required Expertise/Skills Expertise in machine learning and artificial intelligence methodologies Strong background in digital pathology, medical imaging, or computational image analysis Proficiency in programming languages such as Python, R, or equivalent scientific computing tools Experience with deep learning frameworks and large-scale data analysis Knowledge of whole-slide imaging and computational pathology workflows Strong statistical analysis and data modelling skills Ability to manage and interpret complex biomedical datasets Excellent scientific writing and communication skills Experience in securing or contributing to research funding proposals Ability to collaborate effectively in multidisciplinary clinical and research teams Leadership and mentoring capabilities for junior researchers Salary Details Salary will be aligned with UCL Senior Research Fellow pay scales and will depend on qualifications, experience, and academic track record. Application Deadline Not specified in the provided listing; applications will be reviewed according to UCL recruitment timelines and departmental requirements.

Louise Johnson Associate Professorship of Molecular and Cellular Biochemistry General Description The Department of Biochemistry at the University of Oxford is inviting applications for the Louise Johnson Associate Professorship of Molecular and Cellular Biochemistry. This position forms part of a cohort of academic appointments established in recognition of Professor Louise Johnson's pioneering research and his mentorship of women and other underrepresented scientists in the field. The successful candidate will join a vibrant, collaborative, and internationally diverse academic community within the Department of Biochemistry. The role offers the opportunity to pursue an innovative and independent research programme addressing fundamental questions in the broad area of molecular and cellular biology. Depending on the research focus, the appointee will join one of the department's interdisciplinary research themes that apply biochemical, biophysical, and computational approaches to key challenges in cell and developmental biology, genetics, microbiology, human health, and infectious disease processes. The post holder will benefit from high-quality laboratory and office space in the Dorothy Crowfoot Hodgkin Building, which houses the Department of Biochemistry and its advanced research facilities. The department provides access to outstanding colleagues, collaborative networks, and state-of-the art infrastructure including biological imaging, structural biology, and biochemical research facilities. The University is strongly committed to mentoring and career development at all career stages, and departmental research groups benefit from access to extensive training programmes for doctoral researchers and early career scientists. In addition to leading an independent research programme, the successful candidate will contribute to the teaching and training of students in the Department of Biochemistry. This includes teaching on the four year Master's level degree programme in Molecular and Cellular Biochemistry and serving as a Tutorial Fellow at Trinity College. The role also involves contributing to departmental and college academic activities and helping to maintain a supportive, inclusive, and intellectually stimulating research and teaching environment. Applications are particularly encouraged from early or mid career researchers who are already leading, or have the clear potential to lead, innovative and independent research programmes. The University of Oxford actively welcomes applications from women, ethnic minority groups, and individuals from other backgrounds that are underrepresented in academic positions at the institution. Eligibility Criteria Applicants must hold a doctoral degree (DPhil/PhD) in a relevant biologically related discipline and have appropriate postdoctoral research experience. Candidates should demonstrate an internationally recognized research record or clear potential to achieve international recognition through impactful publications appropriate to their career stage. Applicants must demonstrate the ability to establish and lead an independent research programme, secure competitive research funding, and contribute effectively to undergraduate and postgraduate teaching. A commitment to fostering an ethical, inclusive, and collaborative research culture is essential. Candidates should also be willing to contribute to the administrative and outreach responsibilities of the department and college, including activities that support widening access to higher education. Required Expertise/Skills Expertise in molecular and cellular biochemistry or related areas of biological science Ability to develop and lead an innovative, independent research programme Strong record of high-quality research publications or clear potential to achieve international recognition Capacity to obtain and manage research funding Experience or commitment to undergraduate and graduate teaching and mentoring Strong communication and interpersonal skills suitable for academic collaboration and teaching Ability to supervise students and contribute to training and professional development Commitment to fostering inclusive and ethical research practices Willingness to contribute to departmental and college administration, outreach, and widening access initiatives Salary Details Combined University and College salary on a scale from £52,815 to £70,918 per annum, increasing each year to the top of the scale, plus additional college allowances where applicable. Application Deadline 12:00 noon on Monday, 20 April 2026

Contract term: This is a full-time, fixed term (4 years) position on Crick terms and conditions of employment. Reporting to: Paul Nurse, Principal Group Leader About us The Francis Crick Institute is Europe's largest biomedical research institute under one roof. Our world-class scientists and staff collaborate on a wide range of biomedical research activities. The Crick is a place for collaboration, innovation and exploration across many disciplines. A space where researchers can pursue big and bold ideas and discover answers to crucial scientific questions. We support them in a dynamic environment which fosters excellence with state-of-the-art infrastructure, cutting-edge facilities, and a creative and curious culture. We've removed traditional boundaries of departments, divisions and disciplines. We have the freedom to carry out high-quality, bold research. Creating a space for discovery without boundaries helps us to turn our science into benefits for human health and the economy. About the Nurse Lab The Nurse Lab investigates one of the most fundamental questions in biology: how cells control their division. Using the fission yeast Schizosaccharomyces pombe as a powerful model system for eukaryotic cells, the lab studies how Cyclin Dependent Kinases (CDKs) coordinate DNA replication, mitosis and cell division and control progression through the cell cycle. Our research combines cell biology, molecular genetics, biochemistry and systems biology approaches to uncover the fundamental mechanisms that govern the eukaryotic cell cycle. About the role We are seeking a creative and highly motivated Postdoctoral Fellow to investigate the mechanisms controlling eukaryotic cell cycle progression. You will lead an independent research project within the lab exploring how CDK activity is regulated and coordinates key cell cycle events. Depending on your research interests, your work could investigate areas including the G1/S transition, mitotic onset, nuclear transport of cell cycle regulators, CDK substrate phosphorylation or the role of chromatin in CDK regulation. This is an exciting opportunity to tackle fundamental questions in cell biology within a highly collaborative environment, with scope to develop new approaches, contribute to wider projects and to learn how to support PhD researchers. Leading an independent research project investigating cell cycle regulation. Designing and carrying out experiments using cell biology, molecular genetics and biochemical approaches. Analysing CDK regulation and its role in DNA replication, mitosis and cell cycle control. Developing and applying new experimental approaches, with training provided where required. Collaborating with other lab researchers and contributing to wider lab projects. Communicating research findings through publications and scientific presentations. Supporting and guiding PhD students where appropriate. About you You will have: PhD in cell biology, molecular genetics, biochemistry, or a related discipline. Strong experimental design and data interpretation skills. Ability to independently develop and deliver a research project. Ability to work effectively within a multidisciplinary and collaborative research environment. Strong scientific communication and presentation skills. A proactive, creative and curious approach to solving challenging biological questions. About Working at the Crick Our values Everyone who works at the Crick has a valuable role to play in advancing the Crick's mission and shaping our culture! We arebold. We make space for creative, dynamic and imaginative ideas and approaches. We're not afraid to do things differently. We areopen. We're highly collaborative and interactive, and make sure our activities are visible to the outside world. We arecollegial. We show respect for one another, work cooperatively and support the wider community. At the Francis Crick Institute, we believe that diversity and inclusion are essential to driving innovation and scientific discovery. We are committed to creating a workplace where everyone feels valued, respected, and empowered to succeed, regardless of their background, identity, or personal circumstances. We actively encourage applications from individuals of all genders, ethnicities, abilities, and experiences. Weare aDisability Confident: Committedemployer andwant to ensure that everyone can apply and be part of our recruitment processes and sowe'llmake reasonable adjustments if you need them - just let us know when you apply. If you needassistancewith applying (i.e., would like to apply by phone or post)please email: . What will you receive? At the Francis Crick Institute, we value our team members and are proud to offer an extensive range of benefits to support their well-being and development: Visas: Applicants for this role will be eligible for sponsorship to work in the UK Generous Leave: 28 days of annual leave, plus three additional days over Christmas and bank holidays. Pension Scheme: Defined contribution pension with employer contributions of up to 16%. 24/7 GP consultation services. Occupational health services and mental health support programs. Eye care vouchers and discounted healthcare plans. Work-Life Balance: Childcare support allowance. Annual leave purchase options. Crick Networks offering diverse groups' support, community and inclusive social events. Discounted gym memberships, bike-to-work scheme, and shopping discounts. Subsidised on-site restaurant and social spaces for team interaction. Career support: A Post-doc to PI programme and other career development activities Please note you must meet the essential criteria listed within the Role Profile, to have your application reviewed. We reserve the right to withdraw this advert at any given time due to the number of applications received.

Salary for this Role: From £47,500, with benefits, subject to skills and experience. Job Title: Postdoctoral Fellow - Frohlich Lab. Closing Date: 24/Sept/.59 GMT Contract term: This is a full-time, fixed term (4 years) position on Crick terms and conditions of employment. Reporting to: Fabian Fröhlich, Group Leader. About us The Francis Crick Institute is Europe's largest biomedical research institute under one roof. Our world-class scientists and staff collaborate on vital research to help prevent, diagnose and treat illnesses such as cancer, heart disease, infectious diseases and neurodegenerative conditions. The Crick is a place for collaboration, innovation and exploration across many disciplines. A space where the brightest minds can pursue big and bold ideas and discover answers to crucial scientific questions. We support them in a dynamic environment which fosters excellence with state-of-the-art infrastructure, cutting-edge facilities, and a creative and curious culture. We've removed traditional boundaries of departments, divisions and disciplines and instead have an open approach that supports every researcher. This gives us the freedom to take risks and carry out high-quality, pioneering research. Creating a space for discovery without boundaries helps us to turn our science into benefits for human health and the economy. About the Fröhlich Lab The Fröhlich Lab combines quantitative biology with scientific machine learning (SciML) to understand how cells respond to perturbations and uncover fundamental principles of cellular behaviour. Bringing together expertise across mathematics, physics, biology, engineering and data science, we integrate mechanistic models, machine learning and high-throughput experiments to study cellular signalling and cell states across scales. About the role We are seeking an ambitious Postdoctoral Fellow to develop the next generation of deep mechanistic models (DMMs; Fabrini & Fröhlich, bioRxiv 2026, doi: 10.64898/2026.07.30.741759) for biological systems. You will lead a computational research project extending DMMSs from population-level to single-cell data, combining neural networks with mechanistic differential equation models to understand signalling differences between individual cells. You will develop open-source computational tools () and apply them to cutting-edge single-cell datasets generated within the lab and from public resources. There is significant scope to shape the project around your interests, including live-cell imaging, flow matching, optimal transport or cell-cycle modelling. This is an exciting opportunity for a computational researcher who wants to develop innovative machine-learning methods while tackling fundamental biological questions within a highly interdisciplinary environment. What you'll be doing Leading an independent research project in scientific machine learning and mechanistic modelling. Developing deep mechanistic models for single-cell biological data. Building and maintaining reusable, open-source computational tools. Applying new methods to biological datasets and interpreting their biological significance. Collaborating with computational and experimental researchers across the Crick and internationally. Publishing your research and presenting at national and international conferences. Supporting and mentoring graduate students where appropriate. Essential PhD in mathematics, physics, data science, engineering, systems biology or a related field, or be in the final stages of PhD submission. Strong scientific programming skills in Python. Knowledge of mathematical models of biological systems and numerical methods for differential equations. Experience developing and pursuing independent research ideas. Strong written and verbal scientific communication skills. A collaborative, cross-disciplinary approach and interest in applying computational methods to biological questions. Commitment to reproducible research and open science. Desirable Experience with machine learning frameworks such as JAX or PyTorch with a focus on single-cell methods such as optimal transport or flow matching. Knowledge of cell biology, biochemistry relevant to signalling and cell cycle pathways. Experience with modern software development practices or high-performance computing. About Working at the Crick Our values Everyone who works at the Crick has a valuable role to play in advancing the Crick's mission and shaping our culture! We are bold. We make space for creative, dynamic and imaginative ideas and approaches. We're not afraid to do things differently. We are open. We're highly collaborative and interactive, and make sure our activities are visible to the outside world. We are collegial. We show respect for one another, work cooperatively and support the wider community. At the Francis Crick Institute, we believe that diversity and inclusion are essential to driving innovation and scientific discovery. We are committed to creating a workplace where everyone feels valued, respected, and empowered to succeed, regardless of their background, identity, or personal circumstances. We actively encourage applications from individuals of all genders, ethnicities, abilities, and experiences. We are a Disability Confident : Committed employer and want to ensure that everyone can apply and be part of our recruitment processes and so we'll make reasonable adjustments if you need them - just let us know when you apply. What will you receive? Visa: Applicants for this role will be eligible for sponsorship to work in the UK. Generous Leave: 28 days of annual leave, plus three additional days over Christmas and bank holidays. Pension Scheme: Defined contribution pension with employer contributions of up to 16%. Health & Well-being: 24/7 GP consultation services. Occupational health services and mental health support programs. Eye care vouchers and discounted healthcare plans. Work-Life Balance: Back-up care for dependents. Childcare support allowance. Annual leave purchase options. Crick Networks offering diverse groups' support, community and inclusive social events. Perks: Discounted gym memberships, bike-to-work scheme, and shopping discounts. Subsidised on-site restaurant and social spaces for team interaction. Career support: A Post-doc to PI programme and other career development activities. We reserve the right to withdraw this advert at any given time due to the number of applications received. The Francis Crick Institute is a biomedical discovery institute researching the biology underlying human health. At the Crick, scientists and staff collaborate to stretch the very limits of what we know about how life works. Our work is helping to understand why disease develops and to translate discoveries into new ways to prevent, diagnose and treat illnesses such as cancer, heart disease, stroke, infections and neurodegenerative diseases. The Francis Crick Institute is a charity, founded by the Medical Research Council, Cancer Research UK, Wellcome, UCL (University College London), Imperial College London and King's College London.

Francis Crick Institute Ltd in London is seeking an ambitious Postdoctoral Fellow for the Fröhlich Lab to develop the next generation of deep mechanistic models for single-cell data, combining neural networks with mechanistic differential equations. You will lead an independent project, build reusable open-source tools, apply methods to single-cell datasets, collaborate across Crick and international teams, and present at conferences; success includes mentoring students and publishing research.

Salary for this Role: From £47,500, with benefits, subject to skills and experience. Job Title: Postdoctoral Fellow - Frohlich Lab. Closing Date: 24/Sept/.59 GMT Contract term: This is a full-time, fixed term (4 years) position on Crick terms and conditions of employment. Reporting to: Fabian Fröhlich, Group Leader. About us The Francis Crick Institute is Europe's largest biomedical research institute under one roof. Our world-class scientists and staff collaborate on vital research to help prevent, diagnose and treat illnesses such as cancer, heart disease, infectious diseases and neurodegenerative conditions. The Crick is a place for collaboration, innovation and exploration across many disciplines. A space where the brightest minds can pursue big and bold ideas and discover answers to crucial scientific questions. We support them in a dynamic environment which fosters excellence with state-of-the-art infrastructure, cutting-edge facilities, and a creative and curious culture. We've removed traditional boundaries of departments, divisions and disciplines and instead have an open approach that supports every researcher. This gives us the freedom to take risks and carry out high-quality, pioneering research. Creating a space for discovery without boundaries helps us to turn our science into benefits for human health and the economy. About the Fröhlich Lab The Fröhlich Lab combines quantitative biology with scientific machine learning (SciML) to understand how cells respond to perturbations and uncover fundamental principles of cellular behaviour. Bringing together expertise across mathematics, physics, biology, engineering and data science, we integrate mechanistic models, machine learning and high-throughput experiments to study cellular signalling and cell states across scales. About the role We are seeking an ambitious Postdoctoral Fellow to develop the next generation of deep mechanistic models (DMMs; Fabrini & Fröhlich, bioRxiv 2026, doi: 10.64898/2026.07.30.741759) for biological systems. You will lead a computational research project extending DMMSs from population-level to single-cell data, combining neural networks with mechanistic differential equation models to understand signalling differences between individual cells. You will develop open-source computational tools () and apply them to cutting-edge single-cell datasets generated within the lab and from public resources. There is significant scope to shape the project around your interests, including live-cell imaging, flow matching, optimal transport or cell-cycle modelling. This is an exciting opportunity for a computational researcher who wants to develop innovative machine-learning methods while tackling fundamental biological questions within a highly interdisciplinary environment. What you'll be doing Leading an independent research project in scientific machine learning and mechanistic modelling. Developing deep mechanistic models for single-cell biological data. Building and maintaining reusable, open-source computational tools. Applying new methods to biological datasets and interpreting their biological significance. Collaborating with computational and experimental researchers across the Crick and internationally. Publishing your research and presenting at national and international conferences. Supporting and mentoring graduate students where appropriate. Essential PhD in mathematics, physics, data science, engineering, systems biology or a related field, or be in the final stages of PhD submission. Strong scientific programming skills in Python. Knowledge of mathematical models of biological systems and numerical methods for differential equations. Experience developing and pursuing independent research ideas. Strong written and verbal scientific communication skills. A collaborative, cross-disciplinary approach and interest in applying computational methods to biological questions. Commitment to reproducible research and open science. Desirable Experience with machine learning frameworks such as JAX or PyTorch with a focus on single-cell methods such as optimal transport or flow matching. Knowledge of cell biology, biochemistry relevant to signalling and cell cycle pathways. Experience with modern software development practices or high-performance computing. About Working at the Crick Our values Everyone who works at the Crick has a valuable role to play in advancing the Crick's mission and shaping our culture! We are bold. We make space for creative, dynamic and imaginative ideas and approaches. We're not afraid to do things differently. We are open. We're highly collaborative and interactive, and make sure our activities are visible to the outside world. We are collegial. We show respect for one another, work cooperatively and support the wider community. At the Francis Crick Institute, we believe that diversity and inclusion are essential to driving innovation and scientific discovery. We are committed to creating a workplace where everyone feels valued, respected, and empowered to succeed, regardless of their background, identity, or personal circumstances. We actively encourage applications from individuals of all genders, ethnicities, abilities, and experiences. We are a Disability Confident : Committed employer and want to ensure that everyone can apply and be part of our recruitment processes and so we'll make reasonable adjustments if you need them - just let us know when you apply. What will you receive? Visa: Applicants for this role will be eligible for sponsorship to work in the UK. Generous Leave: 28 days of annual leave, plus three additional days over Christmas and bank holidays. Pension Scheme: Defined contribution pension with employer contributions of up to 16%. Health & Well-being: 24/7 GP consultation services. Occupational health services and mental health support programs. Eye care vouchers and discounted healthcare plans. Work-Life Balance: Back-up care for dependents. Childcare support allowance. Annual leave purchase options. Crick Networks offering diverse groups' support, community and inclusive social events. Perks: Discounted gym memberships, bike-to-work scheme, and shopping discounts. Subsidised on-site restaurant and social spaces for team interaction. Career support: A Post-doc to PI programme and other career development activities. We reserve the right to withdraw this advert at any given time due to the number of applications received. The Francis Crick Institute is a biomedical discovery institute researching the biology underlying human health. At the Crick, scientists and staff collaborate to stretch the very limits of what we know about how life works. Our work is helping to understand why disease develops and to translate discoveries into new ways to prevent, diagnose and treat illnesses such as cancer, heart disease, stroke, infections and neurodegenerative diseases. The Francis Crick Institute is a charity, founded by the Medical Research Council, Cancer Research UK, Wellcome, UCL (University College London), Imperial College London and King's College London.