.Senior Principal Scientist (Project Enablement) under the leadership of Location: Cambridge, Babraham Research Campus (minimum 3 days on site)We are looking for a passionate and dedicated scientific professional with extensive experience in We have recently developed a new approach to driving therapeutic innovation through the creation of Cancer Research Horizons (CRH). We have brought together Cancer Research UK's established drug discovery teams under one organisation and leadership team, combining our unique pipeline of cancer biology expertise and access to CRUK's world-class academic network, cutting edge technology platforms and clinical expertise to 1) bring new treatments to patients faster and 2) tackle the biggest challenges in discovering cancer drugs by seeking out more radical ideas and embracing risk in our bid to achieve success. In this role, you will define the vision and strategy for CRH early project enablement, establishing robust processes to select and advance promising targets into the drug discovery portfolio. You will lead and develop a matrixed team, guiding them to deliver clear go/no-go decisions through deep expertise in target feasibility and druggability.This role uniquely combines cutting-edge screening expertise with deep mechanistic insight to transform early-stage target prosecution. By leveraging a range of hit identification methods (e.g. DEL, AS-MS) and rigorous mechanistic understanding, it ensures only the most viable targets progress into drug discovery, pursuing a de-risked therapeutic targeting strategy to reduce attrition and accelerate timelines. Beyond shaping the science, the successful candidate will have a real opportunity to influence and improve our ways of working, embedding best practices and innovative approaches across teams. This smarter, risk-aware strategy will ultimately deliver higher-quality medicines faster, improving outcomes and bringing life-changing therapies to patients who need them most.In addition to the key strategic leadership elements of this role, the successful candidate will play a pivotal role in training and developing colleagues, including through practical contributions from the bench. You will therefore bring a genuine enthusiasm for working in the lab and guiding those around you. A PhD in Pharmacology, Biochemistry, Chemistry or equivalent experience, with extensive pre-clinical drug discovery experience in industry. Deep intellectual and practical knowledge of methods to assess target feasibility and druggability (eg computational modelling, protein characterisation, assay development, affinity-based methods such as DEL, AS-MS). Demonstrated scientific and project leadership in highly matrixed environments, with extensive experience inspiring, developing, and guiding a diverse world class team through effective matrix management. Significant experience of establishing and leading external academic and industrial collaborations, and technology change projects, to advance organisational capabilityIf you'reexperience we'd still love to hear from you. interested in applying and excited about working with us but are unsure if you have the right skills and We create a working environment that supports your wellbeing and provide a generous benefits package, a wide range of career and personal development opportunities and high-quality tools. Our policies and processes enable you to improve your work-life balance, take positive steps in your career and achieve your personal wellbeing goals.You can explore our benefits by visiting our
Feb 18, 2026
Full time
.Senior Principal Scientist (Project Enablement) under the leadership of Location: Cambridge, Babraham Research Campus (minimum 3 days on site)We are looking for a passionate and dedicated scientific professional with extensive experience in We have recently developed a new approach to driving therapeutic innovation through the creation of Cancer Research Horizons (CRH). We have brought together Cancer Research UK's established drug discovery teams under one organisation and leadership team, combining our unique pipeline of cancer biology expertise and access to CRUK's world-class academic network, cutting edge technology platforms and clinical expertise to 1) bring new treatments to patients faster and 2) tackle the biggest challenges in discovering cancer drugs by seeking out more radical ideas and embracing risk in our bid to achieve success. In this role, you will define the vision and strategy for CRH early project enablement, establishing robust processes to select and advance promising targets into the drug discovery portfolio. You will lead and develop a matrixed team, guiding them to deliver clear go/no-go decisions through deep expertise in target feasibility and druggability.This role uniquely combines cutting-edge screening expertise with deep mechanistic insight to transform early-stage target prosecution. By leveraging a range of hit identification methods (e.g. DEL, AS-MS) and rigorous mechanistic understanding, it ensures only the most viable targets progress into drug discovery, pursuing a de-risked therapeutic targeting strategy to reduce attrition and accelerate timelines. Beyond shaping the science, the successful candidate will have a real opportunity to influence and improve our ways of working, embedding best practices and innovative approaches across teams. This smarter, risk-aware strategy will ultimately deliver higher-quality medicines faster, improving outcomes and bringing life-changing therapies to patients who need them most.In addition to the key strategic leadership elements of this role, the successful candidate will play a pivotal role in training and developing colleagues, including through practical contributions from the bench. You will therefore bring a genuine enthusiasm for working in the lab and guiding those around you. A PhD in Pharmacology, Biochemistry, Chemistry or equivalent experience, with extensive pre-clinical drug discovery experience in industry. Deep intellectual and practical knowledge of methods to assess target feasibility and druggability (eg computational modelling, protein characterisation, assay development, affinity-based methods such as DEL, AS-MS). Demonstrated scientific and project leadership in highly matrixed environments, with extensive experience inspiring, developing, and guiding a diverse world class team through effective matrix management. Significant experience of establishing and leading external academic and industrial collaborations, and technology change projects, to advance organisational capabilityIf you'reexperience we'd still love to hear from you. interested in applying and excited about working with us but are unsure if you have the right skills and We create a working environment that supports your wellbeing and provide a generous benefits package, a wide range of career and personal development opportunities and high-quality tools. Our policies and processes enable you to improve your work-life balance, take positive steps in your career and achieve your personal wellbeing goals.You can explore our benefits by visiting our
Senior Principal Scientist (Project Enablement) under the leadership of Agnes Martin £58,400 - £76,000 plus benefits (includes up to 12% pension contribution and income protection) Reports to: Associate Director, Mechanistic Pharmacology Directorate: Research & Innovation Contract: Permanent Hours: Full time 35 hours per week (4 day week would be considered) Location: Cambridge, Babraham Research Campus (minimum 3 days on site) Closing date: Open until filled. We will be shortlisting on a rolling basis and will close the vacancy once we have received sufficient applications This vacancy may close earlier if a high volume of applications is received or once a suitable candidate is found, therefore we strongly recommend that you apply early to avoid disappointment. Please let us know if there is anything or as soon as possible.in particular if there are any changes or adjustments that would make it easier for you to apply. Please contact or as soon as possible. Visa sponsorship: Cancer Research UK can consider visa sponsorship for this vacancy. If this applies to you, please ensure that this is clearly marked on your application. Recruitment process: 1st stage Teams technical and competency based itnerview, 2nd stage in person interview including pre prepared presentation At Cancer Research UK, we exist to beat cancer. We are looking for a passionate and dedicated scientific professional with extensive experience in pre-clinical drug discovery in an industrial setting. As the world's biggest medical research charity, we've helped bring eleven new cancer drugs to market. However, there is still an urgent need to bring more effective treatments to patients faster. We have developed a new approach to driving therapeutic innovation through the creation of Cancer Research Horizons (CRH). We have brought together Cancer Research UK's established drug discovery teams under one organisation and leadership team, combining our unique pipeline of cancer biology expertise and access to CRUK's world-class academic network, cutting edge technology platforms and clinical expertise to 1) bring new treatments to patients faster and 2) tackle the biggest challenges in discovering cancer drugs by seeking out more radical ideas and embracing risk in our bid to achieve success. Based at sites in Cambridge, the CRUK Scotland Institute in Glasgow, and Newcastle University, Cancer Research Horizons employs 200 staff from both industrial and academic backgrounds What will I be doing? Our strategy sets out to bring deeper mechanistic understanding at the molecular and cellular level to all stages of projects, from idea to pre-clinical candidate. In this role, you will define the vision and strategy for CRH early project enablement, establishing robust processes to select and advance promising targets into the drug discovery portfolio. You will lead and develop a matrixed team, guiding them to deliver clear go/no-go decisions through deep expertise in target feasibility and druggability. You will work closely with the Portfolio Generation team to build a sustainable pipeline, evaluating risks, shaping mitigation strategies, and ensuring projects progress efficiently toward pre-clinical development. In addition, you will provide leadership within the broader CRH TI organisation, shaping strategic direction and driving scientific and technical innovation, including championing new modalities. Key accountabilities include: Provide deep expertise in assessing target feasibility, including, but not limited to, reagent generation, mechanistic characterisation, ligandability, druggability. Work at the intersection between portfolio generation, molecular sciences, chemistry and biosciences to define and prosecute strategies that deliver clear, early go/no-go decisions across a range of challenging target classes. Provide Scientific and Strategic leadership for the assessment of novel targets and mechanisms, to drive innovation and portfolio success. Communicate effectively, to influence multiple stakeholders and collaborate across projects and sites. Promote scientific excellence, through external publication, presentations, and membership of conference committees and Scientific Advisory Boards This role uniquely combines cutting-edge screening expertise with deep mechanistic insight to transform early-stage target prosecution. By leveraging a range of hit identification methods (e.g. DEL, AS-MS) and rigorous mechanistic understanding, it ensures only the most viable targets progress into drug discovery, pursuing a de-risked therapeutic targeting strategy to reduce attrition and accelerate timelines. Beyond shaping the science, the successful candidate will have a real opportunity to influence and improve our ways of working, embedding best practices and innovative approaches across teams. This smarter, risk-aware strategy will ultimately deliver higher-quality medicines faster, improving outcomes and bringing life-changing therapies to patients who need them most. Furthermore, we actively encourage our colleagues to celebrate our science, by attending conferences, presenting posters, giving talks at events and publishing papers. You will form an integral part of the Cancer Research Horizon Drug Discovery team, fostering productive internal collaborations, as well as external academic and industrial partnerships, to progress novel cancer targets towards patient benefit. What are we looking for? In addition to the key strategic leadership elements of this role, the successful candidate will play a pivotal role in training and developing colleagues, including through practical contributions from the bench. You will therefore bring a genuine enthusiasm for working in the lab and guiding those around you. You will also bring: A PhD in Pharmacology, Biochemistry, Chemistry or equivalent experience, with extensive pre-clinical drug discovery experience in industry. Deep intellectual and practical knowledge of methods to assess target feasibility and druggability (eg computational modelling, protein characterisation, assay development, affinity-based methods such as DEL, AS-MS). Proven track record of innovative scientific delivery through driving impactful insight into target characterisation across a range of challenging target classes, through intellectual and laboratory-based contributions Demonstrated scientific and project leadership in highly matrixed environments, with extensive experience inspiring, developing, and guiding a diverse world class team through effective matrix management. Significant experience of establishing and leading external academic and industrial collaborations, and technology change projects, to advance organisational capability Track record of delivering results across a diverse project portfolio by leading driving strategic and scientific initiatives Strong external reputation in drug discovery, evidenced through wide personal network, external presentation and publication in high-impact journals, and influential roles on relevant external committees Strategic, credible, and future thinking leader with strong prioritisation, sound decision making under uncertainty, integrity, openness, and a commitment to EDI. Our organisation values are designed to guide all that we do. Bold: Act with ambition, courage and determination Credible: Act with rigour and professionalism Human : Act to have a positive impact on people Together: Act inclusively and collaboratively We're looking for people who can believe in and embody these organisation values and can use them to drive forward progress against our mission to beat cancer. If you're interested in applying and excited about working with us but are unsure if you have the right skills and experience we'd still love to hear from you. What will I gain? We create a working environment that supports your wellbeing and provide a generous benefits package, a wide range of career and personal development opportunities and high-quality tools. Our policies and processes enable you to improve your work-life balance, take positive steps in your career and achieve your personal wellbeing goals. You can explore our benefits by visiting our careers web page. How do I apply? We operate an anonymised shortlisting process in our commitment to equality, diversity and inclusion. CVs are required for all applications; but we won't be able to view them until we invite you for an interview. Instead, we ask you to complete the work history section of the online application form for us to be able to assess you fairly and objectively. For more information on this career opportunity please visit our website or contact us. For more updates on our work and careers, follow us on: Linked In, Facebook, Instagram, X and YouTube.
Feb 14, 2026
Full time
Senior Principal Scientist (Project Enablement) under the leadership of Agnes Martin £58,400 - £76,000 plus benefits (includes up to 12% pension contribution and income protection) Reports to: Associate Director, Mechanistic Pharmacology Directorate: Research & Innovation Contract: Permanent Hours: Full time 35 hours per week (4 day week would be considered) Location: Cambridge, Babraham Research Campus (minimum 3 days on site) Closing date: Open until filled. We will be shortlisting on a rolling basis and will close the vacancy once we have received sufficient applications This vacancy may close earlier if a high volume of applications is received or once a suitable candidate is found, therefore we strongly recommend that you apply early to avoid disappointment. Please let us know if there is anything or as soon as possible.in particular if there are any changes or adjustments that would make it easier for you to apply. Please contact or as soon as possible. Visa sponsorship: Cancer Research UK can consider visa sponsorship for this vacancy. If this applies to you, please ensure that this is clearly marked on your application. Recruitment process: 1st stage Teams technical and competency based itnerview, 2nd stage in person interview including pre prepared presentation At Cancer Research UK, we exist to beat cancer. We are looking for a passionate and dedicated scientific professional with extensive experience in pre-clinical drug discovery in an industrial setting. As the world's biggest medical research charity, we've helped bring eleven new cancer drugs to market. However, there is still an urgent need to bring more effective treatments to patients faster. We have developed a new approach to driving therapeutic innovation through the creation of Cancer Research Horizons (CRH). We have brought together Cancer Research UK's established drug discovery teams under one organisation and leadership team, combining our unique pipeline of cancer biology expertise and access to CRUK's world-class academic network, cutting edge technology platforms and clinical expertise to 1) bring new treatments to patients faster and 2) tackle the biggest challenges in discovering cancer drugs by seeking out more radical ideas and embracing risk in our bid to achieve success. Based at sites in Cambridge, the CRUK Scotland Institute in Glasgow, and Newcastle University, Cancer Research Horizons employs 200 staff from both industrial and academic backgrounds What will I be doing? Our strategy sets out to bring deeper mechanistic understanding at the molecular and cellular level to all stages of projects, from idea to pre-clinical candidate. In this role, you will define the vision and strategy for CRH early project enablement, establishing robust processes to select and advance promising targets into the drug discovery portfolio. You will lead and develop a matrixed team, guiding them to deliver clear go/no-go decisions through deep expertise in target feasibility and druggability. You will work closely with the Portfolio Generation team to build a sustainable pipeline, evaluating risks, shaping mitigation strategies, and ensuring projects progress efficiently toward pre-clinical development. In addition, you will provide leadership within the broader CRH TI organisation, shaping strategic direction and driving scientific and technical innovation, including championing new modalities. Key accountabilities include: Provide deep expertise in assessing target feasibility, including, but not limited to, reagent generation, mechanistic characterisation, ligandability, druggability. Work at the intersection between portfolio generation, molecular sciences, chemistry and biosciences to define and prosecute strategies that deliver clear, early go/no-go decisions across a range of challenging target classes. Provide Scientific and Strategic leadership for the assessment of novel targets and mechanisms, to drive innovation and portfolio success. Communicate effectively, to influence multiple stakeholders and collaborate across projects and sites. Promote scientific excellence, through external publication, presentations, and membership of conference committees and Scientific Advisory Boards This role uniquely combines cutting-edge screening expertise with deep mechanistic insight to transform early-stage target prosecution. By leveraging a range of hit identification methods (e.g. DEL, AS-MS) and rigorous mechanistic understanding, it ensures only the most viable targets progress into drug discovery, pursuing a de-risked therapeutic targeting strategy to reduce attrition and accelerate timelines. Beyond shaping the science, the successful candidate will have a real opportunity to influence and improve our ways of working, embedding best practices and innovative approaches across teams. This smarter, risk-aware strategy will ultimately deliver higher-quality medicines faster, improving outcomes and bringing life-changing therapies to patients who need them most. Furthermore, we actively encourage our colleagues to celebrate our science, by attending conferences, presenting posters, giving talks at events and publishing papers. You will form an integral part of the Cancer Research Horizon Drug Discovery team, fostering productive internal collaborations, as well as external academic and industrial partnerships, to progress novel cancer targets towards patient benefit. What are we looking for? In addition to the key strategic leadership elements of this role, the successful candidate will play a pivotal role in training and developing colleagues, including through practical contributions from the bench. You will therefore bring a genuine enthusiasm for working in the lab and guiding those around you. You will also bring: A PhD in Pharmacology, Biochemistry, Chemistry or equivalent experience, with extensive pre-clinical drug discovery experience in industry. Deep intellectual and practical knowledge of methods to assess target feasibility and druggability (eg computational modelling, protein characterisation, assay development, affinity-based methods such as DEL, AS-MS). Proven track record of innovative scientific delivery through driving impactful insight into target characterisation across a range of challenging target classes, through intellectual and laboratory-based contributions Demonstrated scientific and project leadership in highly matrixed environments, with extensive experience inspiring, developing, and guiding a diverse world class team through effective matrix management. Significant experience of establishing and leading external academic and industrial collaborations, and technology change projects, to advance organisational capability Track record of delivering results across a diverse project portfolio by leading driving strategic and scientific initiatives Strong external reputation in drug discovery, evidenced through wide personal network, external presentation and publication in high-impact journals, and influential roles on relevant external committees Strategic, credible, and future thinking leader with strong prioritisation, sound decision making under uncertainty, integrity, openness, and a commitment to EDI. Our organisation values are designed to guide all that we do. Bold: Act with ambition, courage and determination Credible: Act with rigour and professionalism Human : Act to have a positive impact on people Together: Act inclusively and collaboratively We're looking for people who can believe in and embody these organisation values and can use them to drive forward progress against our mission to beat cancer. If you're interested in applying and excited about working with us but are unsure if you have the right skills and experience we'd still love to hear from you. What will I gain? We create a working environment that supports your wellbeing and provide a generous benefits package, a wide range of career and personal development opportunities and high-quality tools. Our policies and processes enable you to improve your work-life balance, take positive steps in your career and achieve your personal wellbeing goals. You can explore our benefits by visiting our careers web page. How do I apply? We operate an anonymised shortlisting process in our commitment to equality, diversity and inclusion. CVs are required for all applications; but we won't be able to view them until we invite you for an interview. Instead, we ask you to complete the work history section of the online application form for us to be able to assess you fairly and objectively. For more information on this career opportunity please visit our website or contact us. For more updates on our work and careers, follow us on: Linked In, Facebook, Instagram, X and YouTube.
Overview (Neurodegeneration/Renal Disease) Barrington James is partnering with a leading biopharmaceutical organization to find a skilled Principal Scientist for their Translational Unit. This lab-based role will focus on Neurodegeneration or Renal Disease, bridging the gap between preclinical research and early clinical studies through translational assays in human-derived cells, tissues, and biofluids. Responsibilities Design and execute laboratory experiments to drive scientific understanding and support drug discovery in neurodegeneration or renal disease. Lead the identification, validation, and development of clinical biomarkers and deployable biomarker assays. Apply advanced laboratory techniques including ELISA, flow cytometry, gene/protein expression analysis and proteomics. Troubleshoot assays and collaborate with cross-functional teams to ensure robust study designs. Ensure accurate, detailed lab records and compliance with data integrity and safety protocols. Requirements Essential: PhD in a relevant scientific discipline (e.g., Molecular Biology, Genetics, Immunology, etc.). 3-5+ years of experience in translational research and biomarker development. Expertise in handling primary human cells and performing laboratory techniques such as ELISA, flow cytometry, and gene expression analysis. Experience in either neurodegenerative diseases or renal diseases. Preferred: Strong problem-solving abilities and capability to critically analyse scientific data. Excellent communication skills, both written and verbal, with the ability to present complex data clearly to internal and external stakeholders. Ability to manage multiple priorities, meeting deadlines while maintaining high-performance standards. Independent and collaborative, with a proven track record of defining strategic approaches to research goals. This is a fantastic opportunity to join a dynamic and innovative team and make an impact in drug discovery. Apply now to take your career to the next level. Open to candidates eligible to work in the UK. Recruitment handled by Barrington James.
Feb 12, 2026
Full time
Overview (Neurodegeneration/Renal Disease) Barrington James is partnering with a leading biopharmaceutical organization to find a skilled Principal Scientist for their Translational Unit. This lab-based role will focus on Neurodegeneration or Renal Disease, bridging the gap between preclinical research and early clinical studies through translational assays in human-derived cells, tissues, and biofluids. Responsibilities Design and execute laboratory experiments to drive scientific understanding and support drug discovery in neurodegeneration or renal disease. Lead the identification, validation, and development of clinical biomarkers and deployable biomarker assays. Apply advanced laboratory techniques including ELISA, flow cytometry, gene/protein expression analysis and proteomics. Troubleshoot assays and collaborate with cross-functional teams to ensure robust study designs. Ensure accurate, detailed lab records and compliance with data integrity and safety protocols. Requirements Essential: PhD in a relevant scientific discipline (e.g., Molecular Biology, Genetics, Immunology, etc.). 3-5+ years of experience in translational research and biomarker development. Expertise in handling primary human cells and performing laboratory techniques such as ELISA, flow cytometry, and gene expression analysis. Experience in either neurodegenerative diseases or renal diseases. Preferred: Strong problem-solving abilities and capability to critically analyse scientific data. Excellent communication skills, both written and verbal, with the ability to present complex data clearly to internal and external stakeholders. Ability to manage multiple priorities, meeting deadlines while maintaining high-performance standards. Independent and collaborative, with a proven track record of defining strategic approaches to research goals. This is a fantastic opportunity to join a dynamic and innovative team and make an impact in drug discovery. Apply now to take your career to the next level. Open to candidates eligible to work in the UK. Recruitment handled by Barrington James.
A biotechnology company in Oxford is seeking a Principal Formulation Development Scientist I to lead formulation development for innovative bio-pharmaceuticals. Candidates should have a PhD and extensive experience in drug delivery strategies, recombinant protein formulation, and analytical techniques. This role involves hands-on laboratory work, collaboration with CMC teams, and management responsibilities in a dynamic environment focused on innovation. The successful applicant will contribute to the development of transformative medicines addressing significant patient needs.
Feb 06, 2026
Full time
A biotechnology company in Oxford is seeking a Principal Formulation Development Scientist I to lead formulation development for innovative bio-pharmaceuticals. Candidates should have a PhD and extensive experience in drug delivery strategies, recombinant protein formulation, and analytical techniques. This role involves hands-on laboratory work, collaboration with CMC teams, and management responsibilities in a dynamic environment focused on innovation. The successful applicant will contribute to the development of transformative medicines addressing significant patient needs.
Job Details: Principal Formulation Development Scientist I Full details of the job. Vacancy Name Vacancy Name Principal Formulation Development Scientist I Vacancy No Vacancy No VN705 Employment Type Employment Type Permanent Location of role Location of role Oxford, UK Department Department CMC Key Responsibilities The primary purpose of this role is to serve as a recognized technical leader in formulation development, leveraging extensive experience and expert knowledge to drive innovation and contribute to the company's scientific strategy. The incumbent is expected to advocate for process, platform, and technology improvements, and apply advanced knowledge of scientific principles and the drug development process to solve extremely complex problems. The individual will exercise independent judgment in developing methods and techniques, consistently making the right calls to achieve results. This position will be responsible for conducting and designing experimental investigations to support a low & high dose parenteral bio pharmaceutical in the development and management of integrated formulation strategies supporting Immunocore's bio pharmaceutical platforms. The formulation role will be a hands on role, primarily focussed on lab work designing and performing experimental work. It will also cover drug delivery approaches, investigate novel technologies such as LNP, Pegylation and other delivery systems applicable to biologicals. The role will also cover early stressing studies, formulation excipient screening, CMC process support, drug substance and drug product through to compatibility with final patient delivery systems. Support and direct IUS studies and progress the clinical programmes. Support and respond to main stakeholders, for example Clinical and Regulatory teams, in the delivery of the clinical strategies. To work in close collaboration with the Head of Formulation, CMC teams and related functions to input into the formulation related sections for regulatory filings, development reports and other development related documents. Advanced people management skills are essential, including managing changing priorities while maintaining team motivation. They will create a safe environment for learning from mistakes, establish clear career paths, and hold career development conversations. The individual will engage in difficult conversations where appropriate, inspire action, and show employees how they contribute to higher goals. Conducting experiments, observing, interpreting and responding to results. Maintaining and increasing technical knowledge in relevant fields through self study, observation, attending relevant conferences and training courses. Maintaining accurate records of all work by completing laboratory notebooks on time, following Company procedures. Ensuring that laboratory equipment is operated in accordance with safety and risk guidelines; acting promptly to report any faults or problems to the relevant member of staff. Operating in accordance with the Company's Health and Safety policies, especially within a laboratory environment. Specific Responsibilities Experiments: independently testing and, increasingly, leading lines of investigation. Proposing new experiments based on emerging data and other related information. Providing support on technical aspects to others. Specifically: Develop drug delivery approaches for the biologics portfolio. Bring in new technologies exploring new administration approaches. To conduct and design experiments to establish formulations for TCR platform API and IMP. Lead and direct pre formulation, cycle 1,2 and 3 activities. Conduct drug presentation studies to evaluate alternative drug administration routes (e.g. sub cut). Represent formulation in CMC teams. Investigate compatibility of drug product through delivery devices for patient administration. Investigations in novel drug delivery formats. Perform testing and develop test methods to support stability and formulation studies. Carry out and optimise production of recombinant protein supportive reagents, including conjugations. Communicate key findings to managers and scientists in other groups. Review/sign off of routine assays. Writing of SOPs. Contributing to regulatory documentation. Participation in laboratory maintenance. Perform IUS studies. Perform clinical compatibility studies. Direct investigations into IUS clinical site excursion event impacts. Identify new external scientific technology and collaborations. Introduce new science into the group. Hand on practical role. Priorities: establishing priorities for own work and team based projects; making decisions on prioritisation based on the overall goals of the team, department and project, using direct evidence and personal experience as guidance. Technical Knowledge: sharing knowledge with the wider team and across departments representing the department both internally and externally. May also act as a mentor or manager to other colleagues, especially new hires, sharing scientific and company knowledge. Increasingly providing analysis of new techniques and theories from outside the Company to advance the way the company works; sharing these with leaders across the Company. Laboratory records: ensuring that all records and information are up to date, on time and recorded to the correct standard. Supporting and encouraging others to achieve this. Laboratory equipment: providing technical guidance to others within the team on how to use equipment most effectively; making recommendations regarding acquisition of new pieces of equipment. Health & Safety: championing and helping others to understand H&S within the company, providing ad hoc training as required. Reporting: communicating and presenting research findings at meetings with colleagues, senior management and partners. Experience and Knowledge Essential Background in recombinant protein or antibody formulation, drug delivery of biologics, analytical development or protein characterisation, with proven industry experience and exposure to formulation strategies. Experience in design of formulation studies, including the utilisation of design of experiments principles. Strong expertise in electrophoretic or chromatographic assays and general biochemical lab techniques. Desirable Experience of process development for production of biologics and conjugation of biomolecules. Experience with lyophilisation development of Biotherapeutics. Familiar with biopharmaceutical stability study principles. Familiarity with novel drug delivery formats. Proactive in ensuring high quality of their work and seeking additional responsibilities to help meet the goals of the team. Presented detailed scientific findings and papers to internal and external audiences. Essential Qualifications PhD in bio manufacturing, protein engineering, biochemistry, molecular biology or related discipline. Industrial company experience delivering formulations through drug development phases. Normally requires a PhD in a scientific discipline and a minimum of 8+ years related experience; may include post doctoral experience. About the Company Immunocore (NASDAQ: IMCR) is a pioneering, commercial stage T cell receptor biotechnology company whose purpose is to develop and commercialise a new generation of transformative medicines which address unmet patient needs in oncology, infectious diseases and autoimmune disease. Our leaders in R&D are internationally recognised as some of the biotech industry's most successful drug developers. We are creating not just an environment where great minds can interact but an innovation powerhouse answering the big questions. Focused on delivering first in class biological therapies to patients, we have developed a highly innovative soluble TCR platform. Our ImmTAX molecules underpin a new generation of precision engineered drugs that harness the immune system to treat a broad spectrum of diseases with high unmet medical need, including oncology, infectious diseases and autoimmune diseases. At Immunocore, we recognise that our employees are our greatest asset. We value the unique contributions each person brings to our team. By embracing Science, Trust, Respect, Integrity, Diversity, and Entrepreneurship (STRIDE), we create an environment where collaboration thrives, ideas flourish, and transformative changes happen. STRIDE represents more than just letters; it embodies our shared identity and drives our mission. We are dedicated to developing breakthrough therapies that transform patients' lives, advancing medicine, and supporting one another in these pursuits. Immunocore is proud to be an equal opportunity employer. As such, we are committed to fostering an inclusive workplace where everyone feels valued, respected, and empowered. We encourage applications from individuals of all backgrounds, regardless of race, color, religion, sex, sexual orientation, gender identity or expression, pregnancy, age, national origin, disability status, or any other characteristic protected by law.
Feb 04, 2026
Full time
Job Details: Principal Formulation Development Scientist I Full details of the job. Vacancy Name Vacancy Name Principal Formulation Development Scientist I Vacancy No Vacancy No VN705 Employment Type Employment Type Permanent Location of role Location of role Oxford, UK Department Department CMC Key Responsibilities The primary purpose of this role is to serve as a recognized technical leader in formulation development, leveraging extensive experience and expert knowledge to drive innovation and contribute to the company's scientific strategy. The incumbent is expected to advocate for process, platform, and technology improvements, and apply advanced knowledge of scientific principles and the drug development process to solve extremely complex problems. The individual will exercise independent judgment in developing methods and techniques, consistently making the right calls to achieve results. This position will be responsible for conducting and designing experimental investigations to support a low & high dose parenteral bio pharmaceutical in the development and management of integrated formulation strategies supporting Immunocore's bio pharmaceutical platforms. The formulation role will be a hands on role, primarily focussed on lab work designing and performing experimental work. It will also cover drug delivery approaches, investigate novel technologies such as LNP, Pegylation and other delivery systems applicable to biologicals. The role will also cover early stressing studies, formulation excipient screening, CMC process support, drug substance and drug product through to compatibility with final patient delivery systems. Support and direct IUS studies and progress the clinical programmes. Support and respond to main stakeholders, for example Clinical and Regulatory teams, in the delivery of the clinical strategies. To work in close collaboration with the Head of Formulation, CMC teams and related functions to input into the formulation related sections for regulatory filings, development reports and other development related documents. Advanced people management skills are essential, including managing changing priorities while maintaining team motivation. They will create a safe environment for learning from mistakes, establish clear career paths, and hold career development conversations. The individual will engage in difficult conversations where appropriate, inspire action, and show employees how they contribute to higher goals. Conducting experiments, observing, interpreting and responding to results. Maintaining and increasing technical knowledge in relevant fields through self study, observation, attending relevant conferences and training courses. Maintaining accurate records of all work by completing laboratory notebooks on time, following Company procedures. Ensuring that laboratory equipment is operated in accordance with safety and risk guidelines; acting promptly to report any faults or problems to the relevant member of staff. Operating in accordance with the Company's Health and Safety policies, especially within a laboratory environment. Specific Responsibilities Experiments: independently testing and, increasingly, leading lines of investigation. Proposing new experiments based on emerging data and other related information. Providing support on technical aspects to others. Specifically: Develop drug delivery approaches for the biologics portfolio. Bring in new technologies exploring new administration approaches. To conduct and design experiments to establish formulations for TCR platform API and IMP. Lead and direct pre formulation, cycle 1,2 and 3 activities. Conduct drug presentation studies to evaluate alternative drug administration routes (e.g. sub cut). Represent formulation in CMC teams. Investigate compatibility of drug product through delivery devices for patient administration. Investigations in novel drug delivery formats. Perform testing and develop test methods to support stability and formulation studies. Carry out and optimise production of recombinant protein supportive reagents, including conjugations. Communicate key findings to managers and scientists in other groups. Review/sign off of routine assays. Writing of SOPs. Contributing to regulatory documentation. Participation in laboratory maintenance. Perform IUS studies. Perform clinical compatibility studies. Direct investigations into IUS clinical site excursion event impacts. Identify new external scientific technology and collaborations. Introduce new science into the group. Hand on practical role. Priorities: establishing priorities for own work and team based projects; making decisions on prioritisation based on the overall goals of the team, department and project, using direct evidence and personal experience as guidance. Technical Knowledge: sharing knowledge with the wider team and across departments representing the department both internally and externally. May also act as a mentor or manager to other colleagues, especially new hires, sharing scientific and company knowledge. Increasingly providing analysis of new techniques and theories from outside the Company to advance the way the company works; sharing these with leaders across the Company. Laboratory records: ensuring that all records and information are up to date, on time and recorded to the correct standard. Supporting and encouraging others to achieve this. Laboratory equipment: providing technical guidance to others within the team on how to use equipment most effectively; making recommendations regarding acquisition of new pieces of equipment. Health & Safety: championing and helping others to understand H&S within the company, providing ad hoc training as required. Reporting: communicating and presenting research findings at meetings with colleagues, senior management and partners. Experience and Knowledge Essential Background in recombinant protein or antibody formulation, drug delivery of biologics, analytical development or protein characterisation, with proven industry experience and exposure to formulation strategies. Experience in design of formulation studies, including the utilisation of design of experiments principles. Strong expertise in electrophoretic or chromatographic assays and general biochemical lab techniques. Desirable Experience of process development for production of biologics and conjugation of biomolecules. Experience with lyophilisation development of Biotherapeutics. Familiar with biopharmaceutical stability study principles. Familiarity with novel drug delivery formats. Proactive in ensuring high quality of their work and seeking additional responsibilities to help meet the goals of the team. Presented detailed scientific findings and papers to internal and external audiences. Essential Qualifications PhD in bio manufacturing, protein engineering, biochemistry, molecular biology or related discipline. Industrial company experience delivering formulations through drug development phases. Normally requires a PhD in a scientific discipline and a minimum of 8+ years related experience; may include post doctoral experience. About the Company Immunocore (NASDAQ: IMCR) is a pioneering, commercial stage T cell receptor biotechnology company whose purpose is to develop and commercialise a new generation of transformative medicines which address unmet patient needs in oncology, infectious diseases and autoimmune disease. Our leaders in R&D are internationally recognised as some of the biotech industry's most successful drug developers. We are creating not just an environment where great minds can interact but an innovation powerhouse answering the big questions. Focused on delivering first in class biological therapies to patients, we have developed a highly innovative soluble TCR platform. Our ImmTAX molecules underpin a new generation of precision engineered drugs that harness the immune system to treat a broad spectrum of diseases with high unmet medical need, including oncology, infectious diseases and autoimmune diseases. At Immunocore, we recognise that our employees are our greatest asset. We value the unique contributions each person brings to our team. By embracing Science, Trust, Respect, Integrity, Diversity, and Entrepreneurship (STRIDE), we create an environment where collaboration thrives, ideas flourish, and transformative changes happen. STRIDE represents more than just letters; it embodies our shared identity and drives our mission. We are dedicated to developing breakthrough therapies that transform patients' lives, advancing medicine, and supporting one another in these pursuits. Immunocore is proud to be an equal opportunity employer. As such, we are committed to fostering an inclusive workplace where everyone feels valued, respected, and empowered. We encourage applications from individuals of all backgrounds, regardless of race, color, religion, sex, sexual orientation, gender identity or expression, pregnancy, age, national origin, disability status, or any other characteristic protected by law.
