126 jobs found

Senior Formulation Development Scientist Upperton Pharma Solutions is a Nottingham-based CDMO that specialises in the development and manufacture of pharmaceutical products, providing a complete service from early-stage feasibility to GMP clinical manufacture. Formulations cover a range of delivery routes, typically including oral (tablets & capsules), nasal, inhaled and sterile products. Continued growth and investment into the business has led to the creation of exciting new job opportunities in our new GMP Manufacturing headquarters in Beeston, Nottingham. Upperton Pharma Solutions is undergoing a period of significant expansion to meet international customer demand and offer a comprehensive drug development portfolio, so now is a great time to join our team. Our values ensure that you will be joining a team with a truly positive and progressive culture surrounded by state-of-the-art facilities where you, as a leader, can share your ideas with other gifted and dedicated scientists and clients from around the world, all focused on developing new medicines. The Role The Senior Formulation Development Scientist works to develop new and existing drug products across a range of dosage forms including, but not limited to, tablets, capsules, liquids, inhalers and nasal devices and sterile products. They will lead the laboratory activities on their own development projects, providing technical experience alongside good problem-solving skills, to promote successful outcomes. The post holder will manage project work and support junior staff to achieve project goals and milestones, ensuring project documentation is completed as required. We are especially interested to hear from candidates with solid oral dosage formulation development experience, or with sterile product development. Main duties and responsibilities: Manage own practical and written project work as directed, using the company's processes safely to meet project requirements and meet business critical budgets and timelines. Be a laboratory leader, ensuring work is conducted to high standards across a range of different formulation-based equipment. Support junior staff in project-based activities, providing leadership and mentorship in laboratory activities. Lead development projects as assigned, setting timelines and providing updates at internal and external meetings. Problem-solve, providing solutions to challenges that arise. Ensure accurate completion of process documentation, supporting laboratory work, manufacturing and quality control activities including operating records, lab books, batch records, project reports, SOPs and risk assessments. Work within the Upperton Quality System. Essential skills and experience: Strong technical experience within formulation development Must have excellent communication, influencing and troubleshooting skills. Problem solves and provides solutions to challenges that arise. Uses initiative and anticipates teams' requirements. Able to motivate others. Experience in presenting data at internal and external meetings. Ability to effectively contribute within a team environment and work on own initiative. Meticulous attention to detail. Excellent planning and organisational skills. Ability to work accurately under pressure and to meet deadlines. What you will get in return We offer employees not only a competitive salary but also an excellent suite of benefits including: 33 days annual leave inclusive of bank holidays and your birthday off! Annual bonus based on company and individual performance Company contributory pension package Life insurance Private Medical Insurance through Vitality Internal and external training courses and professional development support Free onsite car parking We know it is the little things that make every day special, so we also organise employee events for you to attend throughout the year, like our annual Christmas party, summer party and charity fund raising events.

Salary for this Role: SLRS: From £45,700 per annum with benefits, subject to skills and experiencePLRS: From £55,555 per annum with benefits, subject to skills and experience Job Title: Senior/Principal Laboratory Research Scientist Reports to: Albane Imbert Closing Date: 13/Mar/.59 GMT Job Description: Senior/Principal Laboratory Research Scientist - Making Lab Science Technology Platform Reporting to: Head of Making Lab STP Contract term: This is a full-time permanent position on Crick terms and conditions of employment. Salary for this Role: Senior Laboratory Research Scientist: From £45,700 with benefits, subject to skills and experience Principal Laboratory Research Scientist: From £55,555 with benefits, subject to skills and experienceThe Francis Crick Institute is Europe's largest biomedical research institute under one roof. Our world-class scientists and staff collaborate on vital research to help prevent, diagnose and treat illnesses such as cancer, heart disease, infectious diseases and neurodegenerative conditions.The Crick is a place for collaboration, innovation and exploration across many disciplines. A space where the brightest minds can pursue big and bold ideas and discover answers to crucial scientific questions. We support them in a dynamic environment which fosters excellence with state-of-the-art infrastructure, cutting-edge facilities, and a creative and curious culture. We've removed traditional boundaries of departments, divisions and disciplines and instead have an open approach that supports every researcher. This gives us the freedom to take risks and carry out high-quality, pioneering research. Creating a space for discovery without boundaries helps us to turn our science into benefits for human health and the economy. About the Making Lab The Making Lab is a Science Technology Platform (STP) operating at the interface of engineering and biology. We accelerate biomedical discovery by designing and delivering advanced engineering solutions to complex scientific challenges.We collaborate across Neuroscience, Structural Biology, Cancer, Immunology and Bioengineering. Our expertise lies in Systems Engineering and Microfluidics & Tissue Engineering. We build robotics, automation platforms, sensing systems and integrated hardware-software tools that power cutting-edge research.As part of the global Making in Research movement, we champion open hardware, rapid prototyping and reproducible system design to drive innovation in science. About the role We are seeking an experienced engineer to join the Making Lab team at Senior (SLRS) or Principal (PLRS) level.This is a hands-on technically demanding role focused on leading the development of robotics, automation and integrated hardware-software systems for biomedical research. You will take ownership of the full project lifecycle, from initial technical scoping and system architecture through electronic hardware integration, embedded and software development, testing, validation and final deployment.Projects span bespoke instrumentation and complex real-time experimental platforms, delivered in close collaboration with neurophysiology groups and teams developing advanced automated lab systems.You will operate within state-of-the-art facilities, including dedicated electronics and integration spaces alongside a workshop for digital and conventional manufacturing (CNC, laser machining, additive manufacturing). At Principal level, you will also contribute to management and long-term technical strategy, infrastructure development and platform planning for the Systems Engineering activity. For more details on the type of projects developed at the lab: What you will be doing You will be responsible for: Leading end-to-end development of bespoke hardware-software systems. Designing and integrating control systems, robotics platforms and data acquisition interfaces. Developing microcontroller-based systems, PCBs and sensor integrations. Applying structured systems engineering methods. Using version control, testing frameworks and clear documentation standards. Providing expert input on experimental design, feasibility and system architecture. Mentoring engineers and deliver hands-on technical training to researchers. Contributing to publications and disseminating technical resources. At principal level, contributing to platform strategy, infrastructure planning and capital investment. About you You will have:(Minimum criteria for SLRS & PLRS )(Minimum criteria for PLRS ) Essential: Degree, PhD or equivalent experience in Engineering, Robotics, Electronics, Mechatronics or related field. Significant hands-on experience in system design and hardware-software integration. Strong programming skills in Python and C within Linux environments. Experience developing control systems, automation platforms or experimental instrumentation. Expertise in microcontrollers, PCB design and sensor integration. Strong understanding of testing, reproducibility and structured engineering workflows. Comfortable leading multidisciplinary technical projects. Skilled communicator with the ability to convey technical concepts clearly to diverse scientific audiences. Desirable: Experience at the engineering-biology interface. Knowledge of signal processing, imaging systems or biomedical instrumentation. Experience with digital fabrication, including CNC machining, 3D printing or laser cutting. About Working at the Crick Our values Everyone who works at the Crick has a valuable role to play in advancing the Crick's mission and shaping our culture! We are bold . We make space for creative, dynamic and imaginative ideas and approaches. We're not afraid to do things differently. We are open . We're highly collaborative and interactive, and make sure our activities are visible to the outside world. We are collegial . We show respect for one another, work cooperatively and support the wider community.At the Francis Crick Institute, we believe that diversity and inclusion are essential to driving innovation and scientific discovery. We are committed to creating a workplace where everyone feels valued, respected, and empowered to succeed, regardless of their background, identity, or personal circumstances. We actively encourage applications from individuals of all genders, ethnicities, abilities, and experiences. We are a Disability Confident: Committed employer and want to ensure that everyone can apply and be part of our recruitment processes and so we'll make reasonable adjustments if you need them - just let us know when you apply. If you need assistance with applying (i.e., would like to apply by phone or post)please email: the Francis Crick Institute, we value our team members and are proud to offer an extensive range of benefits to support their well-being and development: Visas: Applicants for this role will be eligible for sponsorship to work in the UK Generous Leave : 28 days of annual leave, plus three additional days over Christmas and bank holidays. Pension Scheme : Defined contribution pension with employer contributions of up to 16%. Health & Well-being : 24/7 GP consultation services. Occupational health services and mental health support programs. Eye care vouchers and discounted healthcare plans. Work-Life Balance : Back-up care for dependents. Childcare support allowance. Annual leave purchase options. Crick Networks offering diverse groups' support, community and inclusive social events. Perks : Discounted gym memberships, bike-to-work scheme, and shopping discounts. Subsidised on-site restaurant and social spaces for team interaction. Career support: A Post-doc to PI programme

Intercom is the AI Customer Service company on a mission to help businesses provide incredible customer experiences. Our AI agent Fin, the most advanced customer service AI agent on the market, lets businesses deliver always-on, impeccable customer service and ultimately transform their customer experiences for the better. Fin can also be combined with our Helpdesk to become a complete solution called the Intercom Customer Service Suite, which provides AI enhanced support for the more complex or high touch queries that require a human agent. Founded in 2011 and trusted by nearly 30,000 global businesses, Intercom is setting the new standard for customer service. Driven by our core values, we push boundaries, build with speed and intensity, and consistently deliver incredible value to our customers. What's the opportunity? Intercom's Machine Learning team is responsible for defining new ML features, researching appropriate algorithms and technologies, and rapidly getting first prototypes in our customers' hands. We are an extremely product focussed team. We work in partnership with Product and Design functions of teams we support. Our team's dedicated ML product engineers enable us to move to production fast, often shipping to beta in weeks after a successful offline test. We are very passionate about applying machine learning technology, and have productized everything from classic supervised models, to cutting-edge unsupervised clustering algorithms, to novel applications of transformer neural networks. We test and measure the real customer impact of each model we deploy. What will I be doing? Play an active role in hiring, mentoring and career development of other engineers Raise the bar for technical standards, performance, reliability, and operational excellence Identify areas where ML can create value for our customers Identify the right ML framing of product problems - Working with teammates and Product and Design stakeholders Conduct exploratory data analysis and research - Deeply understand the problem area Research and identify the right algorithms and tools - Being pragmatic, but innovating right to the cutting-edge when needed Perform offline evaluation to gather evidence an algorithm will work Work with engineers to bring prototypes to production Plan, measure & socialise learnings to inform iteration Partner deeply with the rest of team, and others, to build excellent ML products What skills might I need? 5-8 years applied ML experience Previous background in a senior/staff role (data science, software development or academic) Significant, demonstrated impact that your work has had on the product and/or the teams Experience as the primary technical leader for a team Strong communication skills, both within engineering teams and across disciplines. Comfort with ambiguity Typically have advanced education in ML or related field (e.g. MSc) Scientific thinking skills Track record shipping ML products PhD or other experience in a research environment Deep experience in an applicable ML area - E.g. NLP, Deep learning, Bayesian methods, Reinforcement learning, clustering Strong stats or math background We are a well treated bunch, with awesome benefits! If there's something important to you that's not on this list, talk to us! Competitive salary and equity in a fast-growing start-up We serve lunch every weekday, plus a variety of snack foods and a fully stocked kitchenp> Peace of mind with life assurance, as well as comprehensive health and dental insurance for you and your dependents Open vacation policy and flexible holidays so you can take time off when you need it Paid maternity leave, as well as 6 weeks paternity leave for fathers, to let you spend valuable time with your loved ones If you're cycling, we've got you covered on the Cycle-to-Work Scheme. With secure bike storage too MacBooks are our standard, but we're happy to get you whatever equipment helps you get your job done We are a diverse bunch of people and we want to continue to attract and retain a diverse range of people into our organisation. We're committed to an inclusive and diverse Intercom! We do not discriminate based on gender, ethnicity, sexual orientation, religion, civil or family status, age, disability, or race. Intercom has a hybrid working policy. We believe that working in person helps us stay connected, collaborate easier and create a great culture while still providing flexibility to work from home. We expect employees to be in the office at least three days per week. We have a radically open and accepting culture at Intercom. We avoid spending time on divisive subjects to foster a safe and cohesive work environment for everyone. As an organization, our policy is to not advocate on behalf of the company or our employees on any social or political topics out of our internal or external communications. We respect personal opinion and expression on these topics on personal social platforms on personal time, and do not challenge or confront anyone for their views on non-work related topics. Our goal is to focus on doing incredible work to achieve our goals and unite the company through our core values . Intercom values diversity and is committed to a policy of Equal Employment Opportunity. Intercom will not discriminate against an applicant or employee on the basis of race, color, religion, creed, national origin, ancestry, sex, gender, age, physical or mental disability, veteran or military status, genetic information, sexual orientation, gender identity, gender expression, marital status, or any other legally recognized protected basis under federal, state, or local law. Interested in building your career at Intercom? Get future opportunities sent straight to your email.

Upperton Pharma Solutions is a leading Nottingham-based contract development and manufacturing organisation (CDMO) specialising in formulation development, clinical trial manufacturing and manufacturing services for a wide range of dosage forms, including oral solids, liquids, semi-solids, and inhalation products. With state-of-the-art facilities and a team of experienced scientists, Upperton offers tailored solutions to accelerate drug development from concept to commercialisation. Upperton are committed to innovation, quality, and share in our customers' dedication to changing the lives of patients. Upperton collaborates closely with global pharmaceutical and biotech companies to bring novel therapies to market efficiently and effectively. Continued growth and investment into the business has led to the creation of exciting new job opportunities; in our new GMP Manufacturing headquarters in Beeston, Nottingham. Upperton Pharma Solutions is undergoing a period of significant expansion to meet international customer demand and offer a comprehensive drug development portfolio, so now is a great time to join our team. The role: Reporting into the Senior Manufacturing Scientist or Principal Scientist position, the role of Manufacturing Scientist / Process Development Scientist will undertake technical transfer/scale-up activities and/or manufacturing to achieve project goals and milestones, and to meet project targets. Dosage forms include, but are not limited to, tablets, capsules, liquids, inhalers, and nasal devices. Activities will be focused on manufacturing activities but will also include equipment and facility cleaning. Main duties and responsibilities: Undertake manufacturing activities as directed, using the company's processes safely to meet batch production requirements. Operate various equipment involved in the manufacturing and testing of products, at various batch scales. Complete all documentation accurately in full to support manufacturing activities, including logbooks, batch records, operational records and log cards. Manage and maintain equipment and the manufacturing facility, including cleaning duties. Support the warehouse team in the receipt and booking in of raw materials and samples where required. Work and adhere to the Upperton Quality Management System. General role responsibilities: Understand & follow the company's Health & Safety Policy & Procedures & report all accidents or any unsafe conditions in the workplace. Ensure training has been received before undertaking specific duties & that all training is recorded in training records. Adhere to all HR policies & procedures, specifically including all absence policies and procedures. Communicate within your own department and cross departmental (QA, Manufacturing, R&D) to ensure that all relevant information is forwarded to the appropriate personnel on a regular & timely basis. Responsible for a small number of direct reports, to provide support and guidance to them, perform 1:1s, performance reviews and objective allocations. Perform analytical testing as required including but not limited to HPLC, GC, KF and Dissolution. Review and approval of analytical data. Essential Skills and experience: Educated to degree level or higher in a related scientific/technical discipline or have relevant work experience. Excellent communication skills, both written and verbal. Excellent organisation skills with strong attention to detail. Proficiency in the use of Microsoft Office applications. Ability to effectively contribute within a team environment and work on own initiative. Strong focus on quality and safety. What you will get in return: We offer employees not only a competitive salary but also an excellent suite of benefits including: 25 days holiday and your birthday off! Company contributory pension package Life insurance Private Medical Insurance through Vitality Internal and external training courses and professional development support Free onsite car parking We know it is the little things that make every day special, so we also organise employee events for you to attend throughout the year, like our annual Christmas party, summer party and charity fund-raising events. Apply. Name First Last Email Phone How did you find out about this position? Current Employee Job Website Search Engine Social Media Upload your CV Click or drag a file to this area to upload. Upload your covering letter Click or drag a file to this area to upload.

Senior Scientist 2- Bioproduction R&D- (12-month fixed-term contract) Revvity's R&D Bioproduction department pioneers advanced expression platforms that power the manufacturing of next-generation biotherapeutics. Our portfolio includes specialized mammalian host cell lines, our innovative transposon-based expression system for rapid identification of high-expressing clones, and gene editing capabilities that enable custom cell line engineering. These technologies support both protein-based therapeutics and viral vector production, addressing the evolving needs of the biopharma industry. Job summary Join Revvity's Bioproduction R&D team as a Senior Scientist 2, where you'll drive innovation in our CHOSOURCE Expression platform. This is a hands-on, lab-based product development role focused on advancing CHO-based expression technologies for biotherapeutic production. You'll tackle real-world expression challenges, from optimizing productivity to enabling successful expression of diverse biologics and translate your findings into commercial products that empower biopharma customers worldwide. Key responsibilities Lead independent research projects to develop and validate new CHOSOURCE platform features for both stable and transient expression applications, from experimental design through execution, analysis, and troubleshooting Mentor junior scientists through training, troubleshooting, and data review Foster collaborative relationships within the team and across Revvity departments Maintain comprehensive laboratory documentation and develop standard operating procedures Present clear, concise data at both internal and external meetings Support IP generation and regulatory documentation as needed for product commercialization Essential Competencies & Requirements Ph.D. in life science (molecular biology, biochemistry, cell biology or genetics) plus minimum 5 years of demonstrated experience in a relevant scientific discipline In-depth knowledge of CHO cell line development, including stable pool generation, single cell cloning, and clone screening Previous experience in transient expression systems and optimization would be a plus Practical understanding of the challenges associated with expressing diverse biologics Advanced molecular biology skills, including expertise in diverse cloning methods (Gibson assembly, Golden Gate assembly), PCR, qPCR, and ddPCR Experience applying Design of Experiment (DoE) methodologies to experimental design Strong analytical mindset with ability to troubleshoot complex technical problems systematically Proven ability to work effectively in cross-functional, fast-paced environments Exceptional team collaboration skills with strong communication abilities and meticulous attention to detail Demonstrated scientific curiosity with a proactive approach to knowledge development Join our team and help shape the future of biotherapeutic production technologies at Revvity.

Senior Optimisation Scientist Role type: Full Time Permanent Location: UK West London Onsite 3 days a week Preferred start date: ASAP LIFE AS A SATALIAN As an organisation, we push the boundaries of data science, optimisation and artificial intelligence to solve the most complex problems in the industry. Satalia, a WPP company is a community of individuals devoted to working on diverse and challenging projects, allowing you to flex your technical skills whilst working with a tight-knit team of high performing colleagues. Led by our founder and WPP Chief AI Officer Daniel Hulme, Satalia's ambition is to become a decentralised organisation of the future. Today, this involves developing tools and processes to liberate and automate manual repetitive tasks, with a focus on freedom, transparency and trust. At the core of our thinking is an approach to wellbeing and inclusivity. We unpack human behaviour and unpick prejudice to ensure a safe and inviting environment. We offer truly flexible working and allow our employees to find the working practice that makes them most productive. At Satalia, your opinion matters and your achievements are celebrated. THE ROLE As a Senior Optimisation Scientist, your role will be leading the design & development of algorithms and decision support tools for a variety of optimisation problems arising from different applications and industries. You will collaborate with clients to gather problem specifications. Your work will support clients' goals and will contribute to the success of many household brands. You will support your peers by sharing your experience, providing mentorship and guidance. YOUR RESPONSIBILITIES Design and implement optimisation algorithms to solve our clients' problems, in sectors such as transportation, logistics, or workforce scheduling. Communicate and interact with clients. Deeply understand the client's domain, the nature of their challenges and what brings most value to them. Clearly articulate the most appropriate solution(s). Lead technical teams in a flat-hierarchical structure. Work collaboratively in an agile, interdisciplinary team on a common goal. Develop production-ready code and provide code reviews to your peers. Mentor, train and support other team members on Optimisation-related topics. MINIMUM QUALIFICATIONS / SKILLS Relevant PhD or Masters Degree with at least 10 years experience working on applied optimisation problems, at least 7 years in industry Proficient and highly experienced in at least one of the following optimisation approaches; Mixed Integer Programming or Metaheuristic approaches Proficient with structuring and implementing optimisation solutions Understanding of agile concepts and ability to work in agile teams. Experience in technical leadership and/or leading teams Excellent written and verbal communication skills in English Reliability and accountability A sense of community and a collaborative mindset Being able to provide constructive feedback and invested in the wellbeing of the team NICE TO HAVE SKILLS Background in transportation and logistics would be an advantage / experience working on transport and/or logistics problems would be an advantage Experience with Java or Rust preferred If you feel like you don't tick all our boxes but know you'd make a fantastic Senior Optimisation Scientist at Satalia, please do apply! We know the value of transferable skills and experiences and would love to hear about these in your cover letter. Satalia is home to some of the brightest minds in AI and if you're looking to join a company who not only values autonomy and freedom, but embraces a culture of inclusion and warmth, we'd love to hear from you. We aim to respond to all applications within 2 weeks. If you have not heard from us within 2 weeks this means your application has been unsuccessful. By applying to Satalia you are expressly giving your consent for the collection and use of your information as described within our Satalia Recruitment Privacy Policy. Good luck!

Barrington James are partnering with a growing quantitative pharmacology and data science consultancy is expanding its Modelling & Simulation team and is seeking a talented (Senior) Modelling & Simulation Scientist to join its collaborative and scientifically driven environment. This organisation partners with biotech, pharma, and research institutes across Europe and North America, supporting programmes from early discovery through to clinical development. With a strong reputation in model-informed drug development, the team works across a broad range of therapeutic areas and modalities. The Role You will join a multidisciplinary Quantitative Pharmacology team delivering high-quality modelling and simulation solutions to external clients. The position offers the opportunity to both support and lead projects across different stages of development. Key responsibilities include: Developing and applying PK/PD, popPK, PBPK and/or QSP models Conducting NCA and analysing preclinical and clinical datasets Interpreting complex data to generate actionable insights for client decision-making Researching disease biology and therapeutic mechanisms of action Preparing technical reports and delivering presentations to clients Supporting proposal development and contributing to new business discussions Staying current with regulatory expectations and modelling best practice This role offers strong career development potential, including exposure to a wide variety of projects, therapeutic areas, and client types. Requirements Essential: PhD in a quantitative discipline involving mathematical/statistical modelling of biological or pharmacological systems 2+ years' experience in modelling & simulation within biotech, pharma, academia, or consultancy Demonstrated experience in PK/PD and/or population modelling Hands-on coding experience (R, MATLAB, or similar) Strong data analysis and interpretation skills Excellent written and verbal communication skills Desirable: Experience across both preclinical and clinical development Familiarity with modelling platforms such as GastroPlus, SimCYP, PK-Sim, Monolix, or SimBiology Experience in oncology or complex disease biology Exposure to regulatory documentation or submissions What's on Offer Competitive salary and benefits package (including private medical insurance) Hybrid working model Exposure to high-impact projects across multiple therapeutic areas Opportunity to contribute to the growth and evolution of a specialist consultancy For a confidential discussion or to apply, please contact: LinkedIn: Vivienne Rae Email:

Senior Scientist, Analytical Development (Chemistry) (Bedford, MA) We are looking to recruit a hands on highly talented Senior Scientist to manage the Analytical Development (AD) Chemistry team, providing onsite support and development for chemistry assays. This onsite Bedford, MA based role is an exciting opportunity to join an experienced organization whose mission is to enable our clients to deliver life changing therapies to patients. Responsibilities Lead and manage the Analytical Development Chemistry team responsible for installation of new equipment, assay development and the daily operation of HPLC, LC/MS, CE SDS, SEC and AUC development operations. Work in close collaboration with the AD Chemistry team to support client projects serving as the analytical methods expert to client teams. Lead and support the transfer, qualification, and validation of GMP analytical methods including but not limited to LC/MS, HPLC, Capillary Electrophoresis, (CE SDS), and AUC assays. Ensure AD Chemistry team members write protocols and generate reports related to QC method transfer, qualification, and validation activities. Provide training and supervision to junior scientists on assay development, instrumentation, and data interpretation. Support and monitor ongoing analytical method performance (e.g., system suitability trending, costing for new client projects) to drive continued improvement and optimization of client's analytical methods. Assist with data trending of assay controls and reference standards, as needed. Lead and support analytical method troubleshooting, as needed. Partner with internal and cross functional departments (e.g., QC and QA) to ensure on time delivery of client projects. Qualifications MS/PhD in Chemistry or related area. Over 10 years of related experience with LC/MS, HPLC, CE SDS and AUC. Proven people manager with the ability to shape teams. Strong expertise in analytical HPLC and LC/MS method development and basic troubleshooting. Independently motivated, detail oriented, and strong problem solving ability. Hands on experience in method development, qualification, validation and/or transfer. Knowledge of quality principles and GMP, ICH and GLP regulations. Experience creating/revising/reviewing operational SOPs, technical documents, protocols, and reports. Ability to work effectively in a fast paced environment. Excellent communication, technical, organizational, and interpersonal skills are essential. Ability to work effectively in a collaborative team environment where results are achieved through influence and the incorporation of multiple points of view.

Upperton Pharma Solutions is a Nottingham-based CDMO that specialises in the development and manufacture of pharmaceutical products, providing a complete service from early-stage feasibility to GMP clinical manufacture. Formulations cover a range of delivery routes, typically including oral (tablets & capsules), nasal and inhaled. Continued growth and investment into the business has led to the creation of exciting new job opportunities; in our new GMP Manufacturing headquarters in Beeston, Nottingham. Upperton Pharma Solutions is undergoing a period of significant expansion to meet international customer demand and offer a comprehensive drug development portfolio, so now is a great time to join our team. The role: Reporting to the QC Manager the QC Senior Scientist I will be directly involved in all aspects of analytical testing. The job holder will be expected to work to cGMP and regulatory requirements and to support client projects from initial proposal to completion. They will be expected to lead analytical aspects of a project and ensure client timelines are met. Main duties and responsibilities: Lead analytical aspects of a project as directed and provide analytical updates to projects during internal and external project meetings as required. Support and supervise analytical staff and the QC Manager in analytical project-based activities, providing leadership and technical support in laboratory activities. Ensure accurate completion of analytical records relating to analytical projects and quality control activities including supporting documentation such as SOPs and risk assessments. Contribute to writing and reviewing analytical protocols and reports as directed. Support the leadership team in ensuring all analytical equipment and laboratory processes are compliant to cGMP and regulatory and customer requirements. Support and lead activities such as LIR's, deviations, CAPA's, change controls. Overseeing client meetings involving QC data, project issues and documentation (protocols, specifications and Certificates of Analysis) General role responsibilities: Understand & follow the company's Health & Safety Policy & Procedures & report all accidents or any unsafe conditions in the workplace. Ensure training has been received before undertaking specific duties & that all training is recorded in training records. Adhere to all HR policies & procedures, specifically including all absence policies and procedures. Communicate within your own department and cross departmental (QA, Manufacturing, R&D) to ensure that all relevant information is forwarded to the appropriate personnel on a regular & timely basis. Responsible for a small number of direct reports, to provide support and guidance to them, perform 1:1s, performance reviews and objective allocations. Perform analytical testing as required including but not limited to HPLC, GC, KF and Dissolution. Review and approval of analytical data Essential Skills and experience: Be educated to degree level or equivalent experience in a related scientific/technical discipline. Extensive experience in industry within a GxP laboratory environment, with practical experience of pharmaceutical analysis using HPLC and/or UPLC methods. Experience working to, and a strong understanding of GMP, GLP, and ICH guidelines. Have excellent communication skills (written and verbal), and proficiency in the use of Microsoft Office applications. Ability to operate in a flexible manner and handling a diverse workload. Positive attitude, autonomous working manner and able to work as part of a large team. Impeccable attention to detail, and excellent organisation, time management and a good documentation practice. Proficiency in chromatographic software Chromeleon. Understanding of safe working practices within a laboratory setting. GC and ELISA experience desirable. Experience with mentoring and training (desirable). Equipment validation experience (IQ, OQ, PQ)(desirable). Working with sterile products (desirable). What you will get in return: We offer employees not only a competitive salary but also an excellent suite of benefits including: 25 days holiday and your birthday off! Company contributory pension package Life insurance Private Medical Insurance through Vitality Internal and external training courses and professional development support Free onsite car parking We know it is the little things that make every day special, so we also organise employee events for you to attend throughout the year, like our annual Christmas party, summer party and charity fund raising events.

Job Details Job Location: Binx Health LTD UK - TROWBRIDGE BA14 0OG Position Type: Full-Time - Salaried Education Level: 4 Year Degree JOB DESCRIPTION -SeniorScientistI, Product Development Who We Are: binxhealth is a healthcare technology and diagnostics company focused on expanding access to care. Thebinxiois the world's first FDA-cleared, CLIA-Waived, point-of-care platform for chlamydia andgonorrheatesting in both males and females. Our rapid, molecular platform brings rapid,accurateand convenient infectious disease testing to clinical settings nationwide. Our solutionshave the ability tobroaden access to care for millions and put proprietary testing solutions in the hands of clinicians everywhere. We work with universities, hospitals, clinics, public health departments, k-12 schools,employersand otherorganisationsto provide patient-centric solutions for their communities. Our Values: We are Bold - Tenacious - One Team - Fixated on Our Mission Atbinxhealth, we know a diverse workforce adds to our collective value and strength as anorganisation. People of colour, the LGBTQIA+ community, disabled candidates and veterans are strongly encouraged to apply.binxhealth is proud to be an Equal Opportunity Employer, committed to equal employment opportunity and fair,equitablecompensation regardless of race, colour, religion, sex, sexual orientation, gender identity, national origin, disability or protected veteran status. The Position The position is within theProductDevelopment team based in Trowbridge, UK developingand optimisingtests for our novel and proprietary PoC Nucleic Acid Amplification Test (NAAT) diagnostic platform, thebinxio. Working within a team of scientists and engineers in an innovative and collaborative scientific environment, you will play a key part in contributing to the creation and development of a range of applications and assays. In addition, you will playan important roleinmaintainingan efficient and professional laboratory. This challenging role will involvedevising and leadingtacticalprojectswithin the IVD design and development process, such ascreatingand assessingnew approachesto NAAT technologies, optimisation,and integrationof NAATs into robust and reproducibleIVD products. The Senior ScientistI will lead by example and cultivateasupportive, collaborative, and rigorous scientific culture. They will demonstratein-depth knowledge and full understanding of area of specialisation,principlesand practices within a professional discipline. They will assessunusual circumstances and use sophisticated analytical and problem-solving techniques toidentifycauses. They will resolve and assess a wide range of issues in creative ways and suggests variations in approach. Responsibilities Design and develop system-based nucleic acid assays Compose well-structured and unbiased experimental plans High quality execution of laboratory experiments Prepare technical reports summarisingproject outcomes and findings that lead into design decisions Optimisation of assays to meet performance requirements and ensure patient safety Development/preparation of quality system procedures and documentation Autonomous management of tactical projects Application of appropriate statistical tests to analyse experimental data Mentors junior technical staff Education, Experience and Demonstrated Skills Typically requires a minimum of 5 years of related experience with a Bachelor'sdegree; or 3 years and a Master'sdegree; or 2 years and a PhD. Strong laboratory-based background Proven ability to plan and run tactical technical projects independentlyand successfully A logical and methodical approach to solving problems and investigations Multiplex PCR assay development and optimisationknowledge Experimental design, data analysis, and effective communication of results Produce and present technical data confidently and to a high quality Strong verbal & written communication Self-motivated and willing to learn Good organisational and time-management skills Attention to detail & well organised Experience in autonomously managing projects Competent in word processing, spreadsheets, statistical analysis and use of databases Advantageous MSc or PhD in a relevant scientific discipline Verification and validation of equipment or products Working within Quality Management and Regulatory frameworks Industrial NAAT IVD product development experience Experience of laboratory management, both managing laboratory staff, behavioural practice within a laboratoryand equipment servicing etc. Experience mentoring junior staff membersin technical experiments

About AQEMIA AQEMIA is a drug invention company dedicated to creating entirely new medicines to address major unmet medical needs. At the core of our mission is QEMI, our proprietary molecule-invention platform, which uniquely combines cutting edge science with advanced technology. Powered by physics based modeling, statistical mechanics, and generative AI, QEMI allows our teams to design novel drug candidates from first principles. What makes AQEMIA different is our commitment to true innovation: our research is dedicated to the invention of new molecular entities, not the refinement of existing ones. We focus on inventing never before seen molecules, without relying on experimental data, and advancing them into a growing pipeline of proprietary programs and strategic partnerships with leading pharmaceutical companies. Our most advanced preclinical programs are currently in vivo optimization, targeting diseases still waiting for effective treatments, offering our teams the opportunity to work on science that can make a real difference in people's lives. For more information, visit and LinkedIn. About our Team AQEMIA brings together a diverse, multidisciplinary team of 65+ professionals based in Paris and London. Our scientists and engineers, including chemists, physicists, machine learning experts, and software engineers, work side by side to push the boundaries of early stage drug discovery. This close collaboration across disciplines is central to our approach, enabling us to tackle complex scientific challenges from first principles and translate cutting edge ideas into novel therapeutic candidates. At AQEMIA, team members are encouraged to contribute their expertise, learn from one another, and play an active role in shaping the future of drug invention. About the Team The mission of the Molecular Simulations Team is threefold: Support drug discovery programs by maximizing the impact of binding free energy calculations in decision making. Build, benchmark and continuously improve reproducible and scalable pipelines for binding free energy calculations, enabling support for multiple programs in parallel. Collaborate closely with our Physics Research Team to integrate innovations from Aqemia's proprietary binding free energy methods. Role Overview As a Senior Application Scientist in the Molecular Simulations Team, you will be a scientific leader and technical expert, contributing to the strategy and delivery of Aqemia's Binding Free Energy Technology. You will help define and evolve how physics based simulations inform and accelerate drug discovery decisions at Aqemia. Key Responsibilities Design and lead large scale simulation studies (e.g., relative and absolute binding free energy predictions). Evaluate and improve modeling protocols for reproducibility, accuracy, and efficiency. Serve as a mentor to junior scientists, promoting best practices in simulation and analysis. Contribute to cross functional planning and the integration of simulations with experimental and AI based insights. Stay at the forefront of developments in molecular simulations and suggest innovations to the team. Support the development and scaling of workflows that can serve multiple drug discovery projects. Work closely with the Research Team to implement improvements and updates to Aqemia's proprietary binding free energy methods. Qualifications & Experience MSc or PhD in Computational Chemistry, Biophysics, Statistical Mechanics, or related discipline. 5+ years of experience in molecular simulations, ideally within a drug discovery context. Deep knowledge of free energy methods, molecular dynamics, and simulation software. Strong programming/scripting ability and experience with workflow automation. Demonstrated ability to lead scientific projects and communicate effectively across disciplines. Nice to Have Experience in machine learning applications for physics based modeling. Track record of scientific publications and contributions to the computational drug discovery community. Preferred Mindset Scientific Rigour: Champion high scientific standards and promote best practices across the team. Humble and Willing to Learn: Lead by example with curiosity and openness to new ideas. Excited by Challenging Scientific Problems: Passionate about solving complex, cutting edge problems and guiding others through them. Pragmatic and Impact Driven: Combine strategic thinking with practical execution to deliver real world impact in a fast paced environment. Leadership through Influence: Inspire and mentor colleagues while fostering a collaborative, high performance culture. Why Join Us? At AQEMIA, we work for a mission: joining us means having your own impact on changing the way drugs are discovered, and helping to shape the direction of our fast growing company and team. Expanding Drug Discovery Pipeline Focused on critical therapeutic areas like Oncology, CNS, Immuno inflammation with in vivo proof of concept/patent stage programs. Collaborations with top Pharma, including a $140M Sanofi deal. World Class Interdisciplinary Team Work alongside exceptional talent at the intersection of technology and life sciences. Our teams combine deep expertise in AI, physics based modeling, biology, and medicinal chemistry to push the boundaries of innovation. DeepTech Recognition AQEMIA is proud to be part of the French Tech 120 and France 2030, highlighting our role as a key player in Europe's DeepTech ecosystem. Prime Location with Flexibility Our offices are located in the heart of Paris and London (King's Cross), with flexible work arrangements including up to two remote days per week. Strong Financial Backing $100M raised from leading European and International investors.

Company Description Join the team redefining how the world experiences design Hiya, g'day, mabuhay, kia ora, 你好, hallo, vítejte! Thanks for stopping by. We know job hunting can be a little time consuming and you're probably keen to find out what's on offer, so we'll get straight to the point. Where and how you can work The buzzing Canva London campus features several buildings around beautiful leafy Hoxton Square in Shoreditch. While our global headquarters is in Sydney, Australia, London is our HQ for Europe, with all kinds of teams based here, plus event spaces to gather our team and communities. You'll experience a warm welcome from our Vibe team at front of house, amazing home cooked food from our Head Chef and a variety of workspaces to hang out with your team mates or get solo work done. That said, we trust our Canvanauts to choose the balance that empowers them and their team to achieve their goals and so you have choice in where and how you work. Job Description At Canva, our mission is to empower the world to design. We're building AI that feels magical and lands real impact for millions of people - helping anyone create with confidence. We're looking for a senior research scientist who lives and breathes reinforcement learning, agentic systems and mixture of expert models to push the frontier of reasoning, tool use, latency and reliability - and ship it to users. About the team We explore multimodal agentic architectures, build scalable training and evaluation loops, and partner closely with product and platform teams to turn breakthroughs into delightful product features. We are a cutting-edge post-training team, developing new multimodal agentic systems. We work on all topics of multimodal modelling, post-training and design agents, we build scalable training and evaluation loops, and partner closely with product and platform teams to turn breakthroughs into delightful product features. We are looking for a person with experience in post-training, reinforcement learning (RL) and mixture of expert models to join our team. About the role You'll drive research directions and play a leading role in hands on work across the agent stack-from reward design and policy optimization to planning, memory, and tool orchestration, dataset construction, to post-training, and the development of novel post-training approaches. You'll design tight experiments, iterate quickly, and land trustworthy conclusions. Most importantly, you'll help convert research into reliable, safe, and high quality product experiences. What you'll do Develop agent systems (planning, multimodal tool use, retrieval, novel training approaches, modeling ablations) for real tasks in design, vision, and language. Scale post-training and RL across distributed systems (PyTorch) with efficient data loaders, tracing/telemetry, stable training of mixture-of-experts (MoE) architectures, and reproducible pipelines; profile, debug, and optimize. Contribute to the research agenda for RL/agentic systems aligned with Canva's product goals; identify high leverage bets and retire dead ends quickly. Build reward models and learning loops: RLHF/RLAIF, preference modeling, DPO/IPO style objectives, offline/online RL, curriculum learning, and credit assignment for multi step reasoning. Develop simulation and sandbox tasks that surface failure modes (planning errors, tool use brittleness, hallucination, unsafe actions) and turn them into measurable targets. Help align on rigorous evaluation for agents (task success, reliability, latency, safety, regressions). Stand up offline suites and online A/B tests; favor simple, controlled experiments that generalize. Collaborate and ship: work shoulder to shoulder with product, design, safety, and platform to land research as reliable features-then iterate. Share and elevate: mentor teammates, present findings internally, and contribute back to the community when it helps the field and our users. You're likely a match if you have Depth in implementing and post-training MoEs/LLMs/VLMs/Diffusion models, with a track record of shipped research or publications in MoEs, RL or agents. Experience modifying, and adapting open source models. Strong experience with experimental design: tight baselines, clean ablations, reproducibility, and clear, data backed conclusions. Fluency in Python and PyTorch; you're comfortable in large ML codebases and can profile, debug, and optimize training and inference. Practical experience building agent loops (planning, tool invocation, retrieval, memory) and evaluating multi step reasoning quality. Hands on experience with policy optimization, reward modeling, and preference learning (e.g., RLHF/RLAIF, DPO/IPO, actor critic/PPO, offline RL). Experience with large scale training (distributed training, experiment tracking, evaluation harnesses) and cloud multimodal tooling. Experience with RL for MoE architectures. Nice to have Experience with video and audio modelling. Experience with multi agent settings. Strength in alignment and safety evaluations, including red teaming and risk mitigation for tool using agents. Contributions to open source, benchmarks, or shared evaluation suites for agents. Additional Information What's in it for you? Achieving our crazy big goals motivates us to work hard - and we do - but you'll experience lots of moments of magic, connectivity and fun woven throughout life at Canva, too. We also offer a range of benefits to set you up for every success in and outside of work. Here's a taste of what's on offer: Equity packages - we want our success to be yours too Inclusive parental leave policy that supports all parents & carers An annual Vibe & Thrive allowance to support your wellbeing, social connection, office setup & more Flexible leave options that empower you to be a force for good, take time to recharge and supports you personally Check out for more info. Other stuff to know We make hiring decisions based on your experience, skills and passion, as well as how you can enhance Canva and our culture. When you apply, please tell us the pronouns you use and any reasonable adjustments you may need during the interview process. We celebrate all types of skills and backgrounds at Canva so even if you don't feel like your skills quite match what's listed above - we still want to hear from you! Please note that interviews are conducted virtually.

Job title: Senior GMP Production Scientist Reporting to: Production Lead Department: GMP No of Direct reports: 2 + Location: Bristol Summary eXmoor Pharma is the only integrated cell and gene therapy CDMO with over 20 years of consultancy expertise embedded across every stage of the CMC journey - from early-phase strategy to process development, GMP manufacturing and commercialisation. We provide comprehensive support across Viral Vectors, Autologous and Allogeneic Cell Therapies, and RNA technologies. This integrated model enables seamless progression from early-phase strategy through to commercial readiness. The Senior GMP Production Scientist will be responsible for routine operations in eXmoor's GMP production suites & take the lead role for establishing GMP Production for a varied range of ATMP clinical products in the eXmoor GMP facility. This is an exciting opportunity to work with eXmoor's globally recognised team of scientists, consultants and engineers. You will work on a wide range of Client projects in a rapidly growing business whilst developing your GMP manufacturing career. Job Purpose The GMP manufacturing facility is capable of handling a wide range of cell and gene therapies as well as small scale complex biologics. The eXmoor facility comprises of two technical areas (Process/Analytical Development & GMP clinical phase production, including a small fill/finish capability and all associated QC), both working closely together such that processes developed in the PD/AD area will be transferred at scale to the GMP suites. The Senior GMP Production Scientists will take responsibility for the day-to-day supervision of GMP production teams and production activities along with playing a lead role in the technology transfer of processes from eXmoor's Process Development Team and clients. This is a generic Job Description for Senior GMP Production scientists in our GMP production team, leading GMP manufacturing in cell culture/fermentation or downstream purification and supporting GMP fill/finish. Main areas of responsibility / key duties Production Processes You will support the tech transfer & scale-up work within the GMP facility to optimise the procedure under GMP conditions and provide data for application to the regulatory authorities. You will be responsible for the supervision of a number of Production Scientists & carry out GMP manufacture of clinical grade ATMP products in accordance with GMP & the Product Specification File. You will ensure GMP materials are specified and minimise the risk of any impact on the production schedules and project timelines by supporting procurement. You will ensure that work in progress and finished products are produced, labelled and stored according to product specification and quality standards. You will develop production methods including closed processing cell culture, downstream purification and fill/finish at varying scales up to 400L. Production Facility Working with the maintenance team you will ensure that the maintenance, operation, cleaning and validation of the Production Equipment are completed in compliance with facility's stated procedures and standards. You will ensure that the appropriate qualification, process validation and regular re-validations are completed successfully and on schedule. You will assist in the monitoring and control of the production environment and ensure that standards of cleanliness and hygiene are maintained. Training You will work as a team to develop and deliver the required initial and continuing training of production & support personnel for production operations, ensuring training is maintained and adapted as required. You will take responsibility for coaching and mentoring more junior Scientists. Documentation You will develop and generate SOPs & Batch Documentation relating to specific GMP facility and manufacturing operations. You will play a leading role in generating & reviewing data and for the application to the regulatory authorities for Clinical Trial Authorisation. Safety You will conduct your duties to the highest quality standard and in a safe way complying with all policies and procedures and with due care and attention for yourself and your peers. You will comply with GMP and lab documentation including Risk assessments, SOPs, COSHH forms, lab notebooks and records. Projects You will present data to our clients and take part in the technical discussion during project team meetings. You will support project management with any scope changes when required. Person Specification Essential Qualifications & Experience MSc in Life Science / Engineering degree or BSc with relevant years industry experience. Considerable experience (3 years plus) of working in GMP clean room facilities, manufacturing ATMP or biological productions for human use. Experience in equipment and process qualification. Experience with generation of materials risk assessments, materials specifications and procurement to GMP principles. Understanding of regulatory & licensing requirements for MHRA in Good Manufacturing Practice as applied to small scale biopharmaceutical production for clinical trials. Operating within a GMP Quality system including the management of production deviations, change controls and the principle of quality risk management. Experience in a supervisory role. This includes the ability to, develop, motivate, and organise a small team. Experience of managing production schedules and ensuring the implementation of operating procedures and efficient record keeping. In depth understanding and experience of one or more of the following unit operations mammalian cell culture (adherent &/or suspension, up to 400L scale) autologous and allogeneic C> purification of vectors, plasmids, whole cells aseptic filling multi-product facilities understanding GMP Resilience and flexibility; able to contribute innovatively to solving processing problems. Previous experience with Technology Transfer from Process Development to GMP environments. Desirable Qualifications & Experience Knowledge of Good Laboratory Practice (GLP) and routine in-process and QC assay techniques for ATMPs. Preparation for audits with FDA/MHRA and other regulatory bodies. Competences Required Organisation, planning and time management Oral and written communication skills Leadership and teamworking Innovation, inquisitiveness, and willingness to learn Attention to detail and getting things finished Problem solving Building constructive relationships and earning respect Motivated by growing a bio-technology business in the CGT / biopharmaceutical market Proficiency in Office365 (including Word, Excel, PowerPoint).