Postdoctoral Project Research Scientist

Postdoctoral Project Research Scientist page is loaded Postdoctoral Project Research Scientist Apply locations London posted on Posted 21 Days Ago job requisition id R1944

Salary for this Role:

£ 45,500 per annum s ubject to skills and experience, with benefits

Job Title:

Reports to:

Closing Date:

Job Description:

Postdoctoral Project Research Scientist - Ultanir Lab (Francis Crick Institute) & Isalan Lab (Imperial College London)

About us

The Francis Crick Institute is Europe's largest biomedical research institute under one roof. Our world-class scientists and staff collaborate on vital research to help prevent, diagnose and treat illnesses such as cancer, heart disease, infectious diseases and neurodegenerative conditions.

The Crick is a place for collaboration, innovation and exploration across many disciplines. A space where the brightest minds can pursue big and bold ideas and discover answers to crucial scientific questions. We support them in a dynamic environment which fosters excellence with state-of-the-art infrastructure, cutting-edge facilities, and a creative and curious culture. We've removed traditional boundaries of departments, divisions and disciplines and instead have an open approach that supports every researcher. This gives us the freedom to take risks and carry out high-quality, pioneering research. Creating a space for discovery without boundaries helps us to turn our science into benefits for human health and the economy.

About the role

This role is a joint collaboration between Sila Ultanir at the Francis Crick Institute and Mark Isalan at Imperial.

The Ultanir lab studies the roles of protein kinases in neuronal development and function. The Isalan lab has long worked on a zinc finger engineering platform for gene therapy (PMID ).

We are recruiting a motivated postdoctoral scientist to join the labs of Kinases and Brain Development at the Francis Crick Institute, London, UK and Mark Isalan at Imperial College London . The postdoctoral scientist will run a translational project to develop zinc finger protein transactivators for treatment of a neurodevelopmental disorder.

In this project, we aim to develop ZFPs which can upregulate CDKL2 mRNA expression and test if these can rescue molecular, cellular and behavioural defects in CDKL5 deficiency models. Postdoctoral researcher will generate and test zinc finger protein transactivators. They will then use CDKL5 knockout mouse models to determine if they can restore CDKL5-mediated functions at molecular and behavioural level. iPSC derived neurons of CDD models and proteomics will also be used to test rescue of phosphorylation substrates. Postdoctoral researcher will lead their own projects, contribute to other projects on a collaborative basis and help train PhD students.

To see the full job description, click here.

About you

The post holder should embody and demonstrate our core Crick values:

Bold; Open; Collegial

Essential

• PhD in biology, biochemistry, neuroscience or a related discipline or in the final stages of PhD submission

• Good knowledge of molecular biology skills
• Experience in mass spectrometry

• Track record of writing papers as evidenced by publications or submitted manuscripts in referred journals
• Evidence of data presentation at scientific meetings

Desirable but not essential

• Experience in research with iPSC derived neurons
• Experience in RNA sequencing
• Experience in neonatal brain injections or in utero electroporation
• Experience in mouse behavioural analysis

To see more about the lab, click here .

About Working at the Crick

Our values

Everyone who works at the Crick has a valuable role to play in advancing the Crick's mission and shaping our culture!

• We arebold. We make space for creative, dynamic and imaginative ideas and approaches. We're not afraid to do things differently.

• We areopen. We're highly collaborative and interactive, and make sure our activities are visible to the outside world.

• We arecollegial. We show respect for one another, work cooperatively and support the wider community.

At the Francis Crick Institute, we believe that diversity and inclusion are essential to driving innovation and scientific discovery. We are committed to creating a workplace where everyone feels valued, respected, and empowered to succeed, regardless of their background, identity, or personal circumstances. We actively encourage applications from individuals of all genders, ethnicities, abilities, and experiences. We want to ensure that everyone can apply and be part of our recruitment processes and so we'll make reasonable adjustments if you need them - just let us know when you apply. If you need assistance with applying (i.e., would like to apply by phone or post)please email:

To find out more about life at the Crick click here .

What will you receive?

At the Francis Crick Institute, we value our team members and are proud to offer an extensive range of benefits to support their well-being and development:

• Visas: Applicants for this role will be eligible for sponsorship to work in the UK

• Generous Leave: 28 days of annual leave, plus three additional days over Christmas and bank holidays.

• Pension Scheme: Defined contribution pension with employer contributions of up to 16%.

• Health & Well-being:

• 24/7 GP consultation services.

• Occupational health services and mental health support programs.

• Eye care vouchers and discounted healthcare plans.

• Work-Life Balance:

• Back-up care for dependents.

• Childcare support allowance.

• Annual leave purchase options.

• Perks:

• Discounted gym memberships, bike-to-work scheme, and shopping discounts.

• Subsidised on-site restaurant and social spaces for team interaction.