Principal Scientist

CK Group are recruiting for an experienced and dynamic Scientist, at either Senior/ Principal level, to join an early-stage biotechnology start-up, based in Oxford, on a permanent basis.

The Company:

Our client is an early-stage biotechnology start up, combining artificial intelligence (AI), and advanced high-throughput TCR screening techniques to revolutionise the treatment of solid cancers.

Location:

Oxford.

The Role:

To lead the in vivo and in vitro validation of T-cell engagers, and help drive forward the development of TCR engineering and processes.

Responsibilities:

• To perform high-throughput TCR display methods by purifying recombinant TCRs.
• Carry out protein characterisation (expression, purification and biophysical analysis).
• Design and characterise TCRs for disease targets.
• Oversee lab protocols and technical documents.
• To be hands-on in the lab and manage tissue culture preparations.
• Skills in data analysis (using software R) for Next Gen Sequencing analysis - desirable.

Your Background:

• PhD qualified (biochemistry, immunology, cell biology) plus strong laboratory experience (academia and industry).
• Experience in in vivo and in vitro validation of T-cell engagers (TCEs).
• Experience in Investigational New Drug (IND-enabling/ approval) - ESSENTIAL.
• Expertise in cell and immunological assays (flow cytometry, ELISA) with knowledge around cloning and PCR.
• Strong background in protein characterisation and biophysical characterisation.

Benefits:

Competitive salary, option for home working (as per project demands), stock options.

Apply:

It is essential that applicants hold entitlement to work in the UK. Please quote job reference in all correspondence.

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