Job Description Oxford Nanopore Technologies is headquartered at the Oxford Science Park outside Oxford, UK, with satellite offices and a commercial presence in many global locations across the US, APAC, and Europe. Oxford Nanopore employs experts from multiple subject areas including nanopore science, molecular biology and applications, informatics, engineering, electronics, manufacturing, and commercialization. The management team, led by CEO Dr. Gordon Sanghera, has a track record of delivering disruptive technologies to the market. Oxford Nanopore's sequencing platform is unique, offering real-time analysis in fully scalable formats from pocket to population scale, capable of analyzing native DNA or RNA and sequencing any length of fragment to achieve short to ultra-long read lengths. Our goal is to enable the analysis of any living thing, by anyone, anywhere! The Role Our Biologics Development team is responsible for improving the performance of all biological components within our sample preparation kits and flowcells. We are seeking a highly motivated individual with excellent lab skills to join as a Development Scientist. As part of the wider R&D division, we collaborate to deliver new chemistries from conception to customers. This role, based at our Oxford headquarters, will support the development of new nanopore sequencing products, focusing on enhancing fundamental performance metrics to improve outcomes and utility for users of the ONT platform. The successful candidate will be responsible for designing, purifying, and analyzing key protein components that form the backbone of RNA and DNA sequencing chemistries, as well as future nanopore sensing applications. You will interact with various stakeholders across R&D and product divisions in a multidisciplinary environment. What We're Looking For We seek a motivated and detail-oriented candidate with experience in: Biochemical properties of proteins, especially DNA/RNA handling enzymes and membrane proteins. Recombinant protein expression from bacterial systems. Lab-scale purification of proteins using chromatographic methods with AKTA or similar systems. Experimental design and execution focusing on protein function. Targeted chemical modification of proteins. Programming skills in Python, R, or command line for data science. Additional experience in one or more of the following is a plus: Nanopore sensing experiments. Computational tools for protein variant design. Responsibilities Designing and iterating protein variants to improve nanopore sensing performance. Expressing and purifying protein variants at appropriate scales, troubleshooting as needed. Characterizing proteins using biochemical techniques and nanopore-based assays. Analyzing data thoroughly and reporting findings accurately to the team. The ideal candidate will hold a PhD in biochemistry, chemistry, or a related field, or equivalent industrial experience. We value strong attention to detail, organization, and effective communication skills. This role is suited for a dedicated individual eager to learn and grow, with extensive training and mentorship provided. We offer excellent benefits, including a bonus, generous pension contributions, private healthcare, and a competitive salary. Our workspace is in a beautiful environment with landscaped surroundings, water features, and a lake, providing a pleasant working atmosphere. If you want to make a difference through your skills, consider joining our team. Apply today! We are committed to diversity and equal opportunity, assessing all candidates based on merit, qualifications, and ability to perform the job.
Jul 16, 2025
Full time
Job Description Oxford Nanopore Technologies is headquartered at the Oxford Science Park outside Oxford, UK, with satellite offices and a commercial presence in many global locations across the US, APAC, and Europe. Oxford Nanopore employs experts from multiple subject areas including nanopore science, molecular biology and applications, informatics, engineering, electronics, manufacturing, and commercialization. The management team, led by CEO Dr. Gordon Sanghera, has a track record of delivering disruptive technologies to the market. Oxford Nanopore's sequencing platform is unique, offering real-time analysis in fully scalable formats from pocket to population scale, capable of analyzing native DNA or RNA and sequencing any length of fragment to achieve short to ultra-long read lengths. Our goal is to enable the analysis of any living thing, by anyone, anywhere! The Role Our Biologics Development team is responsible for improving the performance of all biological components within our sample preparation kits and flowcells. We are seeking a highly motivated individual with excellent lab skills to join as a Development Scientist. As part of the wider R&D division, we collaborate to deliver new chemistries from conception to customers. This role, based at our Oxford headquarters, will support the development of new nanopore sequencing products, focusing on enhancing fundamental performance metrics to improve outcomes and utility for users of the ONT platform. The successful candidate will be responsible for designing, purifying, and analyzing key protein components that form the backbone of RNA and DNA sequencing chemistries, as well as future nanopore sensing applications. You will interact with various stakeholders across R&D and product divisions in a multidisciplinary environment. What We're Looking For We seek a motivated and detail-oriented candidate with experience in: Biochemical properties of proteins, especially DNA/RNA handling enzymes and membrane proteins. Recombinant protein expression from bacterial systems. Lab-scale purification of proteins using chromatographic methods with AKTA or similar systems. Experimental design and execution focusing on protein function. Targeted chemical modification of proteins. Programming skills in Python, R, or command line for data science. Additional experience in one or more of the following is a plus: Nanopore sensing experiments. Computational tools for protein variant design. Responsibilities Designing and iterating protein variants to improve nanopore sensing performance. Expressing and purifying protein variants at appropriate scales, troubleshooting as needed. Characterizing proteins using biochemical techniques and nanopore-based assays. Analyzing data thoroughly and reporting findings accurately to the team. The ideal candidate will hold a PhD in biochemistry, chemistry, or a related field, or equivalent industrial experience. We value strong attention to detail, organization, and effective communication skills. This role is suited for a dedicated individual eager to learn and grow, with extensive training and mentorship provided. We offer excellent benefits, including a bonus, generous pension contributions, private healthcare, and a competitive salary. Our workspace is in a beautiful environment with landscaped surroundings, water features, and a lake, providing a pleasant working atmosphere. If you want to make a difference through your skills, consider joining our team. Apply today! We are committed to diversity and equal opportunity, assessing all candidates based on merit, qualifications, and ability to perform the job.
Oxford Nanopore Technologies: Our goal is to bring the widest benefits to society through enabling the analysis of anything, by anyone, anywhere. The company has developed a new generation of nanopore-based sensing technology for faster, information rich, accessible and affordable molecular analysis. The first application is DNA/RNA sequencing, and the technology is in development for the analysis of other types of molecules including proteins. The technology is used to understand and characterise the biology of humans and diseases such as cancer, plants, animals, bacteria, viruses, and whole environments. With a thriving culture of ambition and strong innovation goals, Oxford Nanopore is a UK headquartered company with global operations and customers in more than 125 countries. We are looking for a Research Scientist to join the Nanopore Research Team. This exciting and challenging role will be responsible for accelerating our efforts to improve the performance of our baseline nanopores and will also contribute to the development of novel biological nanopores for an increasing range of applications, including protein sequencing. The Details The successful candidate will be responsible for the design, expression and purification, electrophysiological characterisation and the subsequent analysis of a range of nanopores. What We're Looking For The candidate will be in possession of a BSc in biochemistry, physics, biology, chemistry or equivalent. Knowledge of protein structure, membrane proteins and their expression and purification would be advantageous. Furthermore, experience of using the Linux operating system, Python based data analysis and R is highly desirable. Applications are encouraged from candidates who can adapt quickly to new challenges and enjoy working with an agile approach to research. The successful candidate will need to work meticulously to a high standard and be able to perform well under pressure to meet deadlines in a demanding and fast paced environment. We offer outstanding benefits to include an attractive bonus, generous pension contributions, private healthcare and an excellent starting salary. Based within beautiful, landscaped surroundings with tree-lined walks, water features and a lake, all of which make for a wonderful working environment. If you are looking to utilise your skills to really make a difference to humankind, then consider joining our team and apply today! Please note that no terminology in this advert is intended to discriminate on the grounds of a person's gender, marital status, race, religion, colour, age, disability or sexual orientation. Every candidate will be assessed only in accordance with their merits, qualifications and abilities to perform the duties of the job. Oxford Nanopore Technologies: Our goal is to bring the widest benefits to society through enabling the analysis of anything, by anyone, anywhere. The company has developed a new generation of nanopore-based sensing technology for faster, information rich, accessible and affordable molecular analysis. The first application is DNA/RNA sequencing, and the technology is in development for the analysis of other types of molecules including proteins. The technology is used to understand and characterise the biology of humans and diseases such as cancer, plants, animals, bacteria, viruses, and whole environments. With a thriving culture of ambition and strong innovation goals, Oxford Nanopore is a UK headquartered company with global operations and customers in more than 125 countries.
Jul 16, 2025
Full time
Oxford Nanopore Technologies: Our goal is to bring the widest benefits to society through enabling the analysis of anything, by anyone, anywhere. The company has developed a new generation of nanopore-based sensing technology for faster, information rich, accessible and affordable molecular analysis. The first application is DNA/RNA sequencing, and the technology is in development for the analysis of other types of molecules including proteins. The technology is used to understand and characterise the biology of humans and diseases such as cancer, plants, animals, bacteria, viruses, and whole environments. With a thriving culture of ambition and strong innovation goals, Oxford Nanopore is a UK headquartered company with global operations and customers in more than 125 countries. We are looking for a Research Scientist to join the Nanopore Research Team. This exciting and challenging role will be responsible for accelerating our efforts to improve the performance of our baseline nanopores and will also contribute to the development of novel biological nanopores for an increasing range of applications, including protein sequencing. The Details The successful candidate will be responsible for the design, expression and purification, electrophysiological characterisation and the subsequent analysis of a range of nanopores. What We're Looking For The candidate will be in possession of a BSc in biochemistry, physics, biology, chemistry or equivalent. Knowledge of protein structure, membrane proteins and their expression and purification would be advantageous. Furthermore, experience of using the Linux operating system, Python based data analysis and R is highly desirable. Applications are encouraged from candidates who can adapt quickly to new challenges and enjoy working with an agile approach to research. The successful candidate will need to work meticulously to a high standard and be able to perform well under pressure to meet deadlines in a demanding and fast paced environment. We offer outstanding benefits to include an attractive bonus, generous pension contributions, private healthcare and an excellent starting salary. Based within beautiful, landscaped surroundings with tree-lined walks, water features and a lake, all of which make for a wonderful working environment. If you are looking to utilise your skills to really make a difference to humankind, then consider joining our team and apply today! Please note that no terminology in this advert is intended to discriminate on the grounds of a person's gender, marital status, race, religion, colour, age, disability or sexual orientation. Every candidate will be assessed only in accordance with their merits, qualifications and abilities to perform the duties of the job. Oxford Nanopore Technologies: Our goal is to bring the widest benefits to society through enabling the analysis of anything, by anyone, anywhere. The company has developed a new generation of nanopore-based sensing technology for faster, information rich, accessible and affordable molecular analysis. The first application is DNA/RNA sequencing, and the technology is in development for the analysis of other types of molecules including proteins. The technology is used to understand and characterise the biology of humans and diseases such as cancer, plants, animals, bacteria, viruses, and whole environments. With a thriving culture of ambition and strong innovation goals, Oxford Nanopore is a UK headquartered company with global operations and customers in more than 125 countries.
CK Group are working in partnership with Nxera Pharma, to recruit a Membrane Protein Biochemist, to join their Protein Sciences division. This role is ideal for a scientist passionate about GPCRs and biochemistry of membrane proteins. It offers a unique opportunity to contribute to cutting-edge drug discovery in a highly collaborative and innovative environment. Applications are welcomed from candidates with a PhD in Biochemistry, Biophysics or similar, with proven experience in membrane protein expression and purification. Location: Granta Park, Cambridge. About the company: Nxera Pharma (formerly Sosei Heptares) is a technology powered biopharma company, in pursuit of new speciality medicines to improve the lives of patients with unmet needs globally. Their pipeline is focused on addressing major unmet needs in some of the fastest-growing areas of medicine across CNS, GI and immunology, metabolic disorders and rare diseases, and leverages the power of their unique and industry leading GPCR-targeted structure-based drug discovery NxWave platform to provide a sustainable source of best- or first-in-class candidates. In Cambridge UK, Nxera have built outstanding capabilities across their platform, discovery and translational medicine teams, to advance multiple programs from pre-clinical through to early clinical development. About the role: In this role you will focus on the expression and purification of challenging membrane proteins destined for biochemical, biophysical and structural studies to support Nxera s structure-based drug design process. Responsibilities will include: Express and purify membrane proteins for biochemical, biophysical and structural biology applications. Design and engineer membrane protein expression constructs to maximise functional expression in mammalian and insect cell expression systems. Optimise protein expression and fine-tune protein purification workflows to obtain pure, homogeneous and stable membrane proteins. Biochemically and biophysically characterise purified membrane proteins using a range of analytical techniques (fSEC, DLS, SEC-MALS, DSF, FP, etc ). Reconstitute purified membrane proteins in membrane mimetic environments (lipid nanodiscs, liposomes, amphipols, etc ). Assemble and purify homogeneous and stoichiometric multi-component protein complexes. Keep up to date with relevant scientific literature, propose, develop, implement and optimise new methodologies in the fields of membrane protein expression, purification and biochemical characterisation. Prepare and effectively present results (written and oral) to project teams. Demonstrate strong interpersonal skills and collaborate effectively with other Nxera scientists to successfully progress membrane protein targets through the Nxera structure-based drug design pipeline. Maintain detailed and accurate laboratory records. Skills and Experience: A PhD in biochemistry, biophysics or a related discipline Proven molecular biology skills enabling the design and engineering of membrane protein expression constructs tailored to downstream applications. Proficiency in the expression of membrane proteins in mammalian and insect cells expression systems (transfection and transduction-based methods). Practical expertise in optimising purification protocols for membrane proteins. Deep understanding of what constitutes a good membrane protein sample for structural (X-ray crystallography and/or cryo-EM) and biophysical studies (SPR, mass spectrometry). Demonstrable experience in a broad range of biochemical and biophysical techniques. Desirable: Ability to design and interpret protein construct optimisation using in silico methods (e.g. AlphaFold) with wet lab impact. Ability to effectively analyse experimental or predicted structures of membrane proteins (cryoEM, X-ray, in silico ). Experience using molecular graphics software (e.g. Pymol, Chimera, Coot ). Experience with assay development and optimisation for small molecule drug discovery. Experience in the reconstitution of purified membrane proteins in membrane-mimetic environments. What s in it for you? State-of-the-art R&D centre located in the heart of the Cambridge science cluster. Competitive compensation package including discretionary cash bonuses. Eligible for grants of Restricted Stock Units. 26 days annual leave in addition to public holidays. Employer contribution to pension. Private Medical Insurance for employees and family and a cash plan for dental and optical reimbursement. Health and wellbeing benefits including a subsidised individual gym membership. Income protection to cover long term absences due to ill health. Group Death in Service equal to 4x basic annual salary. Apply: It is essential that applicants hold entitlement to work in the UK. Please quote job reference in all correspondence.
Jul 11, 2025
Full time
CK Group are working in partnership with Nxera Pharma, to recruit a Membrane Protein Biochemist, to join their Protein Sciences division. This role is ideal for a scientist passionate about GPCRs and biochemistry of membrane proteins. It offers a unique opportunity to contribute to cutting-edge drug discovery in a highly collaborative and innovative environment. Applications are welcomed from candidates with a PhD in Biochemistry, Biophysics or similar, with proven experience in membrane protein expression and purification. Location: Granta Park, Cambridge. About the company: Nxera Pharma (formerly Sosei Heptares) is a technology powered biopharma company, in pursuit of new speciality medicines to improve the lives of patients with unmet needs globally. Their pipeline is focused on addressing major unmet needs in some of the fastest-growing areas of medicine across CNS, GI and immunology, metabolic disorders and rare diseases, and leverages the power of their unique and industry leading GPCR-targeted structure-based drug discovery NxWave platform to provide a sustainable source of best- or first-in-class candidates. In Cambridge UK, Nxera have built outstanding capabilities across their platform, discovery and translational medicine teams, to advance multiple programs from pre-clinical through to early clinical development. About the role: In this role you will focus on the expression and purification of challenging membrane proteins destined for biochemical, biophysical and structural studies to support Nxera s structure-based drug design process. Responsibilities will include: Express and purify membrane proteins for biochemical, biophysical and structural biology applications. Design and engineer membrane protein expression constructs to maximise functional expression in mammalian and insect cell expression systems. Optimise protein expression and fine-tune protein purification workflows to obtain pure, homogeneous and stable membrane proteins. Biochemically and biophysically characterise purified membrane proteins using a range of analytical techniques (fSEC, DLS, SEC-MALS, DSF, FP, etc ). Reconstitute purified membrane proteins in membrane mimetic environments (lipid nanodiscs, liposomes, amphipols, etc ). Assemble and purify homogeneous and stoichiometric multi-component protein complexes. Keep up to date with relevant scientific literature, propose, develop, implement and optimise new methodologies in the fields of membrane protein expression, purification and biochemical characterisation. Prepare and effectively present results (written and oral) to project teams. Demonstrate strong interpersonal skills and collaborate effectively with other Nxera scientists to successfully progress membrane protein targets through the Nxera structure-based drug design pipeline. Maintain detailed and accurate laboratory records. Skills and Experience: A PhD in biochemistry, biophysics or a related discipline Proven molecular biology skills enabling the design and engineering of membrane protein expression constructs tailored to downstream applications. Proficiency in the expression of membrane proteins in mammalian and insect cells expression systems (transfection and transduction-based methods). Practical expertise in optimising purification protocols for membrane proteins. Deep understanding of what constitutes a good membrane protein sample for structural (X-ray crystallography and/or cryo-EM) and biophysical studies (SPR, mass spectrometry). Demonstrable experience in a broad range of biochemical and biophysical techniques. Desirable: Ability to design and interpret protein construct optimisation using in silico methods (e.g. AlphaFold) with wet lab impact. Ability to effectively analyse experimental or predicted structures of membrane proteins (cryoEM, X-ray, in silico ). Experience using molecular graphics software (e.g. Pymol, Chimera, Coot ). Experience with assay development and optimisation for small molecule drug discovery. Experience in the reconstitution of purified membrane proteins in membrane-mimetic environments. What s in it for you? State-of-the-art R&D centre located in the heart of the Cambridge science cluster. Competitive compensation package including discretionary cash bonuses. Eligible for grants of Restricted Stock Units. 26 days annual leave in addition to public holidays. Employer contribution to pension. Private Medical Insurance for employees and family and a cash plan for dental and optical reimbursement. Health and wellbeing benefits including a subsidised individual gym membership. Income protection to cover long term absences due to ill health. Group Death in Service equal to 4x basic annual salary. Apply: It is essential that applicants hold entitlement to work in the UK. Please quote job reference in all correspondence.
CK Group are working in partnership with Nxera Pharma, to recruit a Membrane Protein Biochemist, to join their Protein Sciences division. This role is ideal for a scientist passionate about GPCRs and biochemistry of membrane proteins. It offers a unique opportunity to contribute to cutting-edge drug discovery in a highly collaborative and innovative environment. Applications are welcomed from candidates with a PhD in Biochemistry, Biophysics or similar, with proven experience in membrane protein expression and purification. Location: Granta Park, Cambridge. About the company: Nxera Pharma (formerly Sosei Heptares) is a technology powered biopharma company, in pursuit of new speciality medicines to improve the lives of patients with unmet needs globally. Their pipeline is focused on addressing major unmet needs in some of the fastest-growing areas of medicine across CNS, GI and immunology, metabolic disorders and rare diseases, and leverages the power of their unique and industry leading GPCR-targeted structure-based drug discovery NxWave platform to provide a sustainable source of best- or first-in-class candidates. In Cambridge UK, Nxera have built outstanding capabilities across their platform, discovery and translational medicine teams, to advance multiple programs from pre-clinical through to early clinical development. About the role: In this role you will focus on the expression and purification of challenging membrane proteins destined for biochemical, biophysical and structural studies to support Nxera s structure-based drug design process. Responsibilities will include: Express and purify membrane proteins for biochemical, biophysical and structural biology applications. Design and engineer membrane protein expression constructs to maximise functional expression in mammalian and insect cell expression systems. Optimise protein expression and fine-tune protein purification workflows to obtain pure, homogeneous and stable membrane proteins. Biochemically and biophysically characterise purified membrane proteins using a range of analytical techniques (fSEC, DLS, SEC-MALS, DSF, FP, etc ). Reconstitute purified membrane proteins in membrane mimetic environments (lipid nanodiscs, liposomes, amphipols, etc ). Assemble and purify homogeneous and stoichiometric multi-component protein complexes. Keep up to date with relevant scientific literature, propose, develop, implement and optimise new methodologies in the fields of membrane protein expression, purification and biochemical characterisation. Prepare and effectively present results (written and oral) to project teams. Demonstrate strong interpersonal skills and collaborate effectively with other Nxera scientists to successfully progress membrane protein targets through the Nxera structure-based drug design pipeline. Maintain detailed and accurate laboratory records. Skills and Experience: A PhD in biochemistry, biophysics or a related discipline Proven molecular biology skills enabling the design and engineering of membrane protein expression constructs tailored to downstream applications. Proficiency in the expression of membrane proteins in mammalian and insect cells expression systems (transfection and transduction-based methods). Practical expertise in optimising purification protocols for membrane proteins. Deep understanding of what constitutes a good membrane protein sample for structural (X-ray crystallography and/or cryo-EM) and biophysical studies (SPR, mass spectrometry). Demonstrable experience in a broad range of biochemical and biophysical techniques. Desirable: Ability to design and interpret protein construct optimisation using in silico methods (e.g. AlphaFold) with wet lab impact. Ability to effectively analyse experimental or predicted structures of membrane proteins (cryoEM, X-ray, in silico ). Experience using molecular graphics software (e.g. Pymol, Chimera, Coot ). Experience with assay development and optimisation for small molecule drug discovery. Experience in the reconstitution of purified membrane proteins in membrane-mimetic environments. What s in it for you? State-of-the-art R&D centre located in the heart of the Cambridge science cluster. Competitive compensation package including discretionary cash bonuses. Eligible for grants of Restricted Stock Units. 26 days annual leave in addition to public holidays. Employer contribution to pension. Private Medical Insurance for employees and family and a cash plan for dental and optical reimbursement. Health and wellbeing benefits including a subsidised individual gym membership. Income protection to cover long term absences due to ill health. Group Death in Service equal to 4x basic annual salary. Apply: It is essential that applicants hold entitlement to work in the UK. Please quote job reference in all correspondence.
Jul 09, 2025
Full time
CK Group are working in partnership with Nxera Pharma, to recruit a Membrane Protein Biochemist, to join their Protein Sciences division. This role is ideal for a scientist passionate about GPCRs and biochemistry of membrane proteins. It offers a unique opportunity to contribute to cutting-edge drug discovery in a highly collaborative and innovative environment. Applications are welcomed from candidates with a PhD in Biochemistry, Biophysics or similar, with proven experience in membrane protein expression and purification. Location: Granta Park, Cambridge. About the company: Nxera Pharma (formerly Sosei Heptares) is a technology powered biopharma company, in pursuit of new speciality medicines to improve the lives of patients with unmet needs globally. Their pipeline is focused on addressing major unmet needs in some of the fastest-growing areas of medicine across CNS, GI and immunology, metabolic disorders and rare diseases, and leverages the power of their unique and industry leading GPCR-targeted structure-based drug discovery NxWave platform to provide a sustainable source of best- or first-in-class candidates. In Cambridge UK, Nxera have built outstanding capabilities across their platform, discovery and translational medicine teams, to advance multiple programs from pre-clinical through to early clinical development. About the role: In this role you will focus on the expression and purification of challenging membrane proteins destined for biochemical, biophysical and structural studies to support Nxera s structure-based drug design process. Responsibilities will include: Express and purify membrane proteins for biochemical, biophysical and structural biology applications. Design and engineer membrane protein expression constructs to maximise functional expression in mammalian and insect cell expression systems. Optimise protein expression and fine-tune protein purification workflows to obtain pure, homogeneous and stable membrane proteins. Biochemically and biophysically characterise purified membrane proteins using a range of analytical techniques (fSEC, DLS, SEC-MALS, DSF, FP, etc ). Reconstitute purified membrane proteins in membrane mimetic environments (lipid nanodiscs, liposomes, amphipols, etc ). Assemble and purify homogeneous and stoichiometric multi-component protein complexes. Keep up to date with relevant scientific literature, propose, develop, implement and optimise new methodologies in the fields of membrane protein expression, purification and biochemical characterisation. Prepare and effectively present results (written and oral) to project teams. Demonstrate strong interpersonal skills and collaborate effectively with other Nxera scientists to successfully progress membrane protein targets through the Nxera structure-based drug design pipeline. Maintain detailed and accurate laboratory records. Skills and Experience: A PhD in biochemistry, biophysics or a related discipline Proven molecular biology skills enabling the design and engineering of membrane protein expression constructs tailored to downstream applications. Proficiency in the expression of membrane proteins in mammalian and insect cells expression systems (transfection and transduction-based methods). Practical expertise in optimising purification protocols for membrane proteins. Deep understanding of what constitutes a good membrane protein sample for structural (X-ray crystallography and/or cryo-EM) and biophysical studies (SPR, mass spectrometry). Demonstrable experience in a broad range of biochemical and biophysical techniques. Desirable: Ability to design and interpret protein construct optimisation using in silico methods (e.g. AlphaFold) with wet lab impact. Ability to effectively analyse experimental or predicted structures of membrane proteins (cryoEM, X-ray, in silico ). Experience using molecular graphics software (e.g. Pymol, Chimera, Coot ). Experience with assay development and optimisation for small molecule drug discovery. Experience in the reconstitution of purified membrane proteins in membrane-mimetic environments. What s in it for you? State-of-the-art R&D centre located in the heart of the Cambridge science cluster. Competitive compensation package including discretionary cash bonuses. Eligible for grants of Restricted Stock Units. 26 days annual leave in addition to public holidays. Employer contribution to pension. Private Medical Insurance for employees and family and a cash plan for dental and optical reimbursement. Health and wellbeing benefits including a subsidised individual gym membership. Income protection to cover long term absences due to ill health. Group Death in Service equal to 4x basic annual salary. Apply: It is essential that applicants hold entitlement to work in the UK. Please quote job reference in all correspondence.
Biochemist Permanent, Full-Time Cambridge area, UK REED Scientific are working with an international biopharmaceutical company who discover, design, and develop some of the most innovative and effective medicines for patients worldwid e. About the Job They are searching for a protein biochemist to join the Biochemistry group at our research facility on Granta Park, Cambridge, UK, working on membrane protein biochemical characterisation to enable drug discovery efforts. Don't worry if you don't have experience in the membrane part- they are willing to train. Skills/experience: The preferred candidate will have (most of) the following: A PhD in biochemistry, biophysics, or a related discipline Good molecular biology skills Knowledge in prokaryotic and eukaryotic expression vectors Knowledge in expression construct design and engineering to successfully express membrane proteins destined for biochemical, biophysical, and structural studies Expertise in the expression of membrane proteins from mammalian and insect cells Expertise in the purification and extensive biochemical characterisation of membrane proteins Experience in the reconstitution of purified membrane proteins in membrane-mimetic environments Familiarity with biochemical and biophysical techniques used to characterise membrane proteins such as luminescence, fluorescence, and FRET-based techniques Understanding of the requirements of purified membrane proteins destined for structural (X-ray and/or CryoEM) and biophysical studies (SPR, mass spectrometry) Excellent organisational skills Benefits State-of-the-art R&D centre located in the heart of the Cambridge science cluster Competitive compensation package including discretionary cash bonuses Eligible for grants of Restricted Stock Units 25 days annual leave in addition to public holidays Employer contribution to pension Private Medical Insurance and a cash plan for dental and optical reimbursement Health and wellbeing benefits including a subsidised individual gym membership Income protection to cover long term absences due to ill health Group Death in Service equal to 4x basic annual salary This is a one-of-a-kind opportunity to join a burgeoning company, and work using state-of-the-art scientific equipment and facilities. If this sounds of interest and you meet the requirements, don't miss this opportunity- hit apply with an up-to-date CV and I'll be in touch.
Dec 05, 2022
Full time
Biochemist Permanent, Full-Time Cambridge area, UK REED Scientific are working with an international biopharmaceutical company who discover, design, and develop some of the most innovative and effective medicines for patients worldwid e. About the Job They are searching for a protein biochemist to join the Biochemistry group at our research facility on Granta Park, Cambridge, UK, working on membrane protein biochemical characterisation to enable drug discovery efforts. Don't worry if you don't have experience in the membrane part- they are willing to train. Skills/experience: The preferred candidate will have (most of) the following: A PhD in biochemistry, biophysics, or a related discipline Good molecular biology skills Knowledge in prokaryotic and eukaryotic expression vectors Knowledge in expression construct design and engineering to successfully express membrane proteins destined for biochemical, biophysical, and structural studies Expertise in the expression of membrane proteins from mammalian and insect cells Expertise in the purification and extensive biochemical characterisation of membrane proteins Experience in the reconstitution of purified membrane proteins in membrane-mimetic environments Familiarity with biochemical and biophysical techniques used to characterise membrane proteins such as luminescence, fluorescence, and FRET-based techniques Understanding of the requirements of purified membrane proteins destined for structural (X-ray and/or CryoEM) and biophysical studies (SPR, mass spectrometry) Excellent organisational skills Benefits State-of-the-art R&D centre located in the heart of the Cambridge science cluster Competitive compensation package including discretionary cash bonuses Eligible for grants of Restricted Stock Units 25 days annual leave in addition to public holidays Employer contribution to pension Private Medical Insurance and a cash plan for dental and optical reimbursement Health and wellbeing benefits including a subsidised individual gym membership Income protection to cover long term absences due to ill health Group Death in Service equal to 4x basic annual salary This is a one-of-a-kind opportunity to join a burgeoning company, and work using state-of-the-art scientific equipment and facilities. If this sounds of interest and you meet the requirements, don't miss this opportunity- hit apply with an up-to-date CV and I'll be in touch.
