Press Tab to Move to Skip to Content Link Select how often (in days) to receive an alert: For 75 years, Charles River employees have worked together to assist in the discovery, development and safe manufacture of new drug therapies. When you join our family, you will have a significant impact on the health and well-being of people across the globe. Whether your background is in life sciences, finance, IT, sales or another area, your skills will play an important role in the work we perform. In return, we'll help you build a career that you can feel passionate about. Charles River Laboratories is seeking a Research Scientist to join our Laboratory Sciences group within our Safety Assessment site located in Shrewsbury, MA. The incumbent will serve as a scientific team member in the conduct of preclinical and clinical research studies at all levels of complexity. Responsibilities include study management, interpretation, and reporting of study data and assuring the regulatory compliance of these projects, as appropriate. Additional responsibilities include serving as a Principal Investigator for the development and validation of biomarker, PK and ADA assays (eg: ligand binding assays, enzymatic assays, Luminex, Bioplex, MSD, Quanterix, ProteinSimple). This individual would be responsible for the composition and execution of validation and sample analysis protocols/plan in accordance with company standard operating procedures and industry regulatory guidelines. This position will serve as the primary scientific contact for key clients and the on-site support of their programs. ESSENTIAL DUTIES AND RESPONSIBILITIES: • Function independently as a Project Scientist, Principal Investigator, Contributing Scientist in the direction and execution of assigned studies in compliance with regulations as they apply to the conduct of preclinical and clinical research. Provide scientific expertise in study conduct, design, and interpretation. • Participate in and coordinate all phases of the study planning process with appropriate departments. • Develop assays, generate high-quality laboratory method, protocols, amendments, reports, and facilitate appropriate changes to study design for assigned projects and programs. • Review, interpret, integrate, and present data on assigned studies. • Writes and edits draft or final reports that document all study related procedures and results. • Analyze scientific problems, troubleshoot analytical methods and technical issues. • Function independently as the point of contact for the planning and execution of sponsor interaction related to assigned studies, including proposal management and study scheduling, conduct and reporting. • Provide prompt verbal or written communication with Sponsors on study related business. • Mentor technical staff in areas such as protocol interpretation, method development and refinement, study-related problem resolution, and execution of validation studies. • Provide technical and scientific guidance to the research staff. • Contribute to testing of new biomarker technologies or introduce improvements in existing technologies. The pay range for this position is between $100,000 to $110,000. Please note that salaries vary within the range based on factors including, but not limited to, experience, skills, education, certifications, and location. Job Qualifications QUALIFICATIONS: • Education: Bachelor's degree (B.S./B.A.) or equivalent in a scientific related discipline. Related Master's degree (M.S./M.A.) or PhD/DVM preferred. Experience: Minimum of 6 years related experience in the development and/or validation of biomarker, PK and ADA assays is preferred (eg: ligand binding assays, enzymatic assays, Luminex, Bioplex, MSD, Quanterix Simoa, ProteinSimple Ella). Experience in a contract research organization is preferred. • Other: Understanding of regulatory requirements of study types assigned, as well as Testing Facility SOPs and the Good Laboratory Practices (GLPs), as appropriate. Effective written and verbal communication skills. Ability to handle multiple projects, prioritize work and meet deadlines. Proficiency in the use of standard software including Microsoft Excel, Word, PowerPoint, etc. and with standard laboratory calculations. Experience with Watson LIMS (preferred). PHYSICAL DEMANDS: • While performing the duties of this job, the employee is regularly required to talk, hear and work/ type at a computer. • Specific vision abilities required by this job include close vision and the ability to adjust focus. WORK ENVIRONMENT: • General office working conditions, the noise level in the work environment is usually quiet. • While performing the duties of this job the employee may occasionally be required to wear protective clothing (goggles, face shield, surgical mask, cap, gloves, scrubs, boots), work near toxic or caustic chemicals, work with biohazards, and/or work with live animals with risk of exposure to allergens and/or zoonotic diseases. • The employee may occasionally be exposed to fumes or airborne particles, unpleasant odors, and/or wet, humid and/or extreme temperature conditions. COMMENTS: • This position may require occasional travel. About Safety Assessment Charles River is committed to helping our partners expedite their preclinical drug development with exceptional safety assessment services, state-of-the-art facilities and expert regulatory guidance. From individual specialty toxicology and IND enabling studies to tailored packages and total laboratory support, our deeply experienced team can design and execute programs that anticipate challenges and avoid roadblocks for a smooth, efficient journey to market. Each year approximately 300 investigational new drug (IND) programs are conducted in our Safety Assessment facilities. About Charles River Charles River is an early-stage contract research organization (CRO). We have built upon our foundation of laboratory animal medicine and science to develop a diverse portfolio of discovery and safety assessment services, both Good Laboratory Practice (GLP) and non-GLP, to support clients from target identification through preclinical development. Charles River also provides a suite of products and services to support our clients' clinical laboratory testing needs and manufacturing activities. Utilizing this broad portfolio of products and services enables our clients to create a more flexible drug development model, which reduces their costs, enhances their productivity and effectiveness to increase speed to market. With over 20,000 employees within 110 facilities in over 20 countries around the globe, we are strategically positioned to coordinate worldwide resources and apply multidisciplinary perspectives in resolving our client's unique challenges. Our client base includes global pharmaceutical companies, biotechnology companies, government agencies and hospitals and academic institutions around the world. At Charles River, we are passionate about our role in improving the quality of people's lives. Our mission, our excellent science and our strong sense of purpose guide us in all that we do, and we approach each day with the knowledge that our work helps to improve the health and well-being of many across the globe. We have proudly worked on 80% of the drugs approved by the U.S. Food and Drug Administration (FDA) in the past five years. We're committed to providing benefits that elevate your quality of life. Based on your position these may include: bonus/incentives based on performance, 401K, paid time off, stock purchase program, Health and wellness coverage, employee and family wellbeing support programs, and work life balance flexibility. Charles River Laboratories is an Equal Opportunity Employer - all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, veteran or disability status. It is unlawful in some states (including Massachusetts) to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability. If you are interested in applying to Charles River Laboratories and need special assistance or an accommodation due to a disability to complete any forms or to otherwise participate in the resume submission process, please contact a member of our Human Resources team by sending an e-mail message to . This contact is for accommodation requests for individuals with disabilities only and cannot be used to inquire about the status of applications. For more information, please visit . Nearest Major Market: Worcester Job Segment: Research Scientist, Pharmaceutical, Testing, Laboratory, Science, Technology, Research
Jul 19, 2025
Full time
Press Tab to Move to Skip to Content Link Select how often (in days) to receive an alert: For 75 years, Charles River employees have worked together to assist in the discovery, development and safe manufacture of new drug therapies. When you join our family, you will have a significant impact on the health and well-being of people across the globe. Whether your background is in life sciences, finance, IT, sales or another area, your skills will play an important role in the work we perform. In return, we'll help you build a career that you can feel passionate about. Charles River Laboratories is seeking a Research Scientist to join our Laboratory Sciences group within our Safety Assessment site located in Shrewsbury, MA. The incumbent will serve as a scientific team member in the conduct of preclinical and clinical research studies at all levels of complexity. Responsibilities include study management, interpretation, and reporting of study data and assuring the regulatory compliance of these projects, as appropriate. Additional responsibilities include serving as a Principal Investigator for the development and validation of biomarker, PK and ADA assays (eg: ligand binding assays, enzymatic assays, Luminex, Bioplex, MSD, Quanterix, ProteinSimple). This individual would be responsible for the composition and execution of validation and sample analysis protocols/plan in accordance with company standard operating procedures and industry regulatory guidelines. This position will serve as the primary scientific contact for key clients and the on-site support of their programs. ESSENTIAL DUTIES AND RESPONSIBILITIES: • Function independently as a Project Scientist, Principal Investigator, Contributing Scientist in the direction and execution of assigned studies in compliance with regulations as they apply to the conduct of preclinical and clinical research. Provide scientific expertise in study conduct, design, and interpretation. • Participate in and coordinate all phases of the study planning process with appropriate departments. • Develop assays, generate high-quality laboratory method, protocols, amendments, reports, and facilitate appropriate changes to study design for assigned projects and programs. • Review, interpret, integrate, and present data on assigned studies. • Writes and edits draft or final reports that document all study related procedures and results. • Analyze scientific problems, troubleshoot analytical methods and technical issues. • Function independently as the point of contact for the planning and execution of sponsor interaction related to assigned studies, including proposal management and study scheduling, conduct and reporting. • Provide prompt verbal or written communication with Sponsors on study related business. • Mentor technical staff in areas such as protocol interpretation, method development and refinement, study-related problem resolution, and execution of validation studies. • Provide technical and scientific guidance to the research staff. • Contribute to testing of new biomarker technologies or introduce improvements in existing technologies. The pay range for this position is between $100,000 to $110,000. Please note that salaries vary within the range based on factors including, but not limited to, experience, skills, education, certifications, and location. Job Qualifications QUALIFICATIONS: • Education: Bachelor's degree (B.S./B.A.) or equivalent in a scientific related discipline. Related Master's degree (M.S./M.A.) or PhD/DVM preferred. Experience: Minimum of 6 years related experience in the development and/or validation of biomarker, PK and ADA assays is preferred (eg: ligand binding assays, enzymatic assays, Luminex, Bioplex, MSD, Quanterix Simoa, ProteinSimple Ella). Experience in a contract research organization is preferred. • Other: Understanding of regulatory requirements of study types assigned, as well as Testing Facility SOPs and the Good Laboratory Practices (GLPs), as appropriate. Effective written and verbal communication skills. Ability to handle multiple projects, prioritize work and meet deadlines. Proficiency in the use of standard software including Microsoft Excel, Word, PowerPoint, etc. and with standard laboratory calculations. Experience with Watson LIMS (preferred). PHYSICAL DEMANDS: • While performing the duties of this job, the employee is regularly required to talk, hear and work/ type at a computer. • Specific vision abilities required by this job include close vision and the ability to adjust focus. WORK ENVIRONMENT: • General office working conditions, the noise level in the work environment is usually quiet. • While performing the duties of this job the employee may occasionally be required to wear protective clothing (goggles, face shield, surgical mask, cap, gloves, scrubs, boots), work near toxic or caustic chemicals, work with biohazards, and/or work with live animals with risk of exposure to allergens and/or zoonotic diseases. • The employee may occasionally be exposed to fumes or airborne particles, unpleasant odors, and/or wet, humid and/or extreme temperature conditions. COMMENTS: • This position may require occasional travel. About Safety Assessment Charles River is committed to helping our partners expedite their preclinical drug development with exceptional safety assessment services, state-of-the-art facilities and expert regulatory guidance. From individual specialty toxicology and IND enabling studies to tailored packages and total laboratory support, our deeply experienced team can design and execute programs that anticipate challenges and avoid roadblocks for a smooth, efficient journey to market. Each year approximately 300 investigational new drug (IND) programs are conducted in our Safety Assessment facilities. About Charles River Charles River is an early-stage contract research organization (CRO). We have built upon our foundation of laboratory animal medicine and science to develop a diverse portfolio of discovery and safety assessment services, both Good Laboratory Practice (GLP) and non-GLP, to support clients from target identification through preclinical development. Charles River also provides a suite of products and services to support our clients' clinical laboratory testing needs and manufacturing activities. Utilizing this broad portfolio of products and services enables our clients to create a more flexible drug development model, which reduces their costs, enhances their productivity and effectiveness to increase speed to market. With over 20,000 employees within 110 facilities in over 20 countries around the globe, we are strategically positioned to coordinate worldwide resources and apply multidisciplinary perspectives in resolving our client's unique challenges. Our client base includes global pharmaceutical companies, biotechnology companies, government agencies and hospitals and academic institutions around the world. At Charles River, we are passionate about our role in improving the quality of people's lives. Our mission, our excellent science and our strong sense of purpose guide us in all that we do, and we approach each day with the knowledge that our work helps to improve the health and well-being of many across the globe. We have proudly worked on 80% of the drugs approved by the U.S. Food and Drug Administration (FDA) in the past five years. We're committed to providing benefits that elevate your quality of life. Based on your position these may include: bonus/incentives based on performance, 401K, paid time off, stock purchase program, Health and wellness coverage, employee and family wellbeing support programs, and work life balance flexibility. Charles River Laboratories is an Equal Opportunity Employer - all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, veteran or disability status. It is unlawful in some states (including Massachusetts) to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability. If you are interested in applying to Charles River Laboratories and need special assistance or an accommodation due to a disability to complete any forms or to otherwise participate in the resume submission process, please contact a member of our Human Resources team by sending an e-mail message to . This contact is for accommodation requests for individuals with disabilities only and cannot be used to inquire about the status of applications. For more information, please visit . Nearest Major Market: Worcester Job Segment: Research Scientist, Pharmaceutical, Testing, Laboratory, Science, Technology, Research
Senior Principal Scientist (Study Monitor) - Preclinical Safety Job ID REQ- Jul 15, 2025 United Kingdom Summary The Preclinical Safety (PCS) department within the Biomedical Research (BR) - Translational Medicine Unit provides non-clinical safety strategy of products in -discovery, -development and -market, globally, with state-of-the-art regulatory compliance. As a Scientific Study monitor, you will join our PCS team to oversee non-clinical research activities for multiple projects across multiple disease areas for in-vivo toxicity and /or in-vitro screening toxicity studies conducted at our CRO partner sites as per the internal strategy and international standards, acting as the primary scientific contact for the Study Director. About the Role Major accountabilities: Formulates and leads/co-leads novel projects with team or enables matrix collaboration on project/technology solutions to achieve creative results for impact on BR goals. Generates innovative ideas within own team and/or project team/functional community to meet new technical requirements and/or answer project key scientific/technical/development questions. Establishes target dates and priorities to enable data-driven advancements in project teams, within own team, and with collaborators, or within functional community. The Study Monitor is appointed to each outsourced preclinical study based on relevant technical expertise, designated disease area and/or scientific background knowledge and acts as the primary scientific contact for the Study Director at the Contract Research Organization (CRO). The Study Monitor is responsible for overseeing the progress of the study and for ensuring that the study is conducted, recorded and reported according to the study protocol. The Study Monitor should ensure that the study is compliant with the appropriate GLP regulations, Novartis animal welfare policies, CRO in-house standard operating procedures, Novartis expert recommendations (where feasible) and all relevant international regulatory guidelines/regulations. Resolution of study related issues, liaisons with internal experts and informing the appropriate people in a timely manner is pivotal to the performance of this role. The study phases and sample delivery timelines should be strategically overviewed and tracked to ensure that internal contributor reports are delivered to the CRO on time and that the CRO meets its agreed main reporting timelines. Communication skill is critical to this role in forming strong working relationship with other Target team members. Works closely with the PCS-Operations and PCS Project Team Member (PTM) to formulate a project outsourcing strategy. Has a working knowledge of HA regulations (Swiss medic, OECD, FDA) to support conduct of GLP compliant toxicology studies. May be PCS part-time PTM Role Requirements • PhD or MVSc/MS/M.Pharm with 7+ years of experiences in drug discovery and/or development, preferably as Study Director or Study Monitor in the early preclinical screening and GLP studies • In-depth knowledge of toxicology assays in early development, Safety pharmacology and genotoxicity • Proficient with full range of techniques used in job and core areas. Working knowledge of tools and processes used in drug design and development. • Excellent communicators, strong team players and have a high level of logistical/planning ability. • Registration and certification with one of the International Toxicology registers. Why Novartis: Our purpose is to reimagine medicine to improve and extend people's lives and our vision is to become the most valued and trusted medicines company in the world. How can we achieve this? With our people. It is our associates that drive us each day to reach our ambitions. Be a part of this mission and join us! Learn more here: Commitment to Diversity and Inclusion: Novartis is committed to building an outstanding, inclusive work environment and diverse teams' representative of the patients and communities we serve. Join our Novartis Network:If this role is not suitable to your experience or career goals but you wish to stay connected to hear more about Novartis and our career opportunities, join the Novartis Network here: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients' lives. Ready to create a brighter future together? Join our Novartis Network:Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients' lives. Ready to create a brighter future together? Join our Novartis Network: Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: Universal Hierarchy Node Innovative Medicines Location United Kingdom Site London (The Westworks) Company / Legal Entity GB16 (FCRS = GB016) Novartis Pharmaceuticals UK Ltd. Novartis is committed to building an outstanding, inclusive work environment and diverse teams' representative of the patients and communities we serve. Job ID REQ- Senior Principal Scientist (Study Monitor) - Preclinical Safety
Jul 19, 2025
Full time
Senior Principal Scientist (Study Monitor) - Preclinical Safety Job ID REQ- Jul 15, 2025 United Kingdom Summary The Preclinical Safety (PCS) department within the Biomedical Research (BR) - Translational Medicine Unit provides non-clinical safety strategy of products in -discovery, -development and -market, globally, with state-of-the-art regulatory compliance. As a Scientific Study monitor, you will join our PCS team to oversee non-clinical research activities for multiple projects across multiple disease areas for in-vivo toxicity and /or in-vitro screening toxicity studies conducted at our CRO partner sites as per the internal strategy and international standards, acting as the primary scientific contact for the Study Director. About the Role Major accountabilities: Formulates and leads/co-leads novel projects with team or enables matrix collaboration on project/technology solutions to achieve creative results for impact on BR goals. Generates innovative ideas within own team and/or project team/functional community to meet new technical requirements and/or answer project key scientific/technical/development questions. Establishes target dates and priorities to enable data-driven advancements in project teams, within own team, and with collaborators, or within functional community. The Study Monitor is appointed to each outsourced preclinical study based on relevant technical expertise, designated disease area and/or scientific background knowledge and acts as the primary scientific contact for the Study Director at the Contract Research Organization (CRO). The Study Monitor is responsible for overseeing the progress of the study and for ensuring that the study is conducted, recorded and reported according to the study protocol. The Study Monitor should ensure that the study is compliant with the appropriate GLP regulations, Novartis animal welfare policies, CRO in-house standard operating procedures, Novartis expert recommendations (where feasible) and all relevant international regulatory guidelines/regulations. Resolution of study related issues, liaisons with internal experts and informing the appropriate people in a timely manner is pivotal to the performance of this role. The study phases and sample delivery timelines should be strategically overviewed and tracked to ensure that internal contributor reports are delivered to the CRO on time and that the CRO meets its agreed main reporting timelines. Communication skill is critical to this role in forming strong working relationship with other Target team members. Works closely with the PCS-Operations and PCS Project Team Member (PTM) to formulate a project outsourcing strategy. Has a working knowledge of HA regulations (Swiss medic, OECD, FDA) to support conduct of GLP compliant toxicology studies. May be PCS part-time PTM Role Requirements • PhD or MVSc/MS/M.Pharm with 7+ years of experiences in drug discovery and/or development, preferably as Study Director or Study Monitor in the early preclinical screening and GLP studies • In-depth knowledge of toxicology assays in early development, Safety pharmacology and genotoxicity • Proficient with full range of techniques used in job and core areas. Working knowledge of tools and processes used in drug design and development. • Excellent communicators, strong team players and have a high level of logistical/planning ability. • Registration and certification with one of the International Toxicology registers. Why Novartis: Our purpose is to reimagine medicine to improve and extend people's lives and our vision is to become the most valued and trusted medicines company in the world. How can we achieve this? With our people. It is our associates that drive us each day to reach our ambitions. Be a part of this mission and join us! Learn more here: Commitment to Diversity and Inclusion: Novartis is committed to building an outstanding, inclusive work environment and diverse teams' representative of the patients and communities we serve. Join our Novartis Network:If this role is not suitable to your experience or career goals but you wish to stay connected to hear more about Novartis and our career opportunities, join the Novartis Network here: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients' lives. Ready to create a brighter future together? Join our Novartis Network:Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients' lives. Ready to create a brighter future together? Join our Novartis Network: Not the right Novartis role for you? Sign up to our talent community to stay connected and learn about suitable career opportunities as soon as they come up: Universal Hierarchy Node Innovative Medicines Location United Kingdom Site London (The Westworks) Company / Legal Entity GB16 (FCRS = GB016) Novartis Pharmaceuticals UK Ltd. Novartis is committed to building an outstanding, inclusive work environment and diverse teams' representative of the patients and communities we serve. Job ID REQ- Senior Principal Scientist (Study Monitor) - Preclinical Safety
Job Description Summary The Preclinical Safety (PCS) department within the Biomedical Research (BR) - Translational Medicine Unit provides non-clinical safety strategies for products in discovery, development, and market, globally, with state-of-the-art regulatory compliance. As a Scientific Study Monitor, you will join our PCS team to oversee non-clinical research activities across multiple projects and disease areas, focusing on in-vivo toxicity and/or in-vitro screening toxicity studies conducted at our CRO partner sites. You will act as the primary scientific contact for the Study Director. Job Responsibilities Lead or co-lead novel projects, facilitating collaboration to achieve impactful results aligned with BR goals. Generate innovative ideas to meet new technical requirements and address key scientific questions. Serve as the appointed Study Monitor for outsourced preclinical studies, based on expertise and scientific background, acting as the primary contact for the Study Director at CROs. Oversee study progress, ensuring conduct, recording, and reporting comply with the protocol, GLP regulations, animal welfare policies, and international guidelines. Resolve study-related issues, liaise with internal experts, and ensure timely communication and report delivery. Develop strong working relationships with team members through effective communication. Collaborate with PCS-Operations and PTM to formulate outsourcing strategies. Maintain knowledge of HA regulations (Swiss medic, OECD, FDA) to support GLP toxicology studies. Potentially serve as a part-time PCS PTM. Role Requirements PhD or MVSc/MS/M.Pharm with 7+ years of experience in drug discovery or development, preferably as Study Director or Study Monitor in early preclinical and GLP studies. Deep knowledge of toxicology assays, safety pharmacology, and genotoxicity. Proficiency with techniques and tools used in drug design and development. Excellent communication skills, strong teamwork, and logistical planning abilities. Registration and certification with an International Toxicology register. Why Novartis: Our purpose is to reimagine medicine to improve and extend lives. Join us to be part of this mission. Learn more: Commitment to Diversity and Inclusion: We strive to build an inclusive, diverse work environment reflecting the communities we serve. Connect with Us: Join the Novartis Network to stay informed about career opportunities: Help us create breakthroughs that change patients' lives. Join our community of passionate professionals. Benefits and Rewards: Discover how we support your personal and professional growth: Skills Desired: Animal Models, Bioinformatics, Chemistry, Clinical Research, Collaboration, Communication, Data Analysis, Drug Development, Drug Discovery, Ethics, Flexibility, Influencing Skills, Laboratory, Lifesciences, Medical Research, Patient Care, Pharmaceutics, Problem Solving, Regulatory Compliance, and more.
Jul 19, 2025
Full time
Job Description Summary The Preclinical Safety (PCS) department within the Biomedical Research (BR) - Translational Medicine Unit provides non-clinical safety strategies for products in discovery, development, and market, globally, with state-of-the-art regulatory compliance. As a Scientific Study Monitor, you will join our PCS team to oversee non-clinical research activities across multiple projects and disease areas, focusing on in-vivo toxicity and/or in-vitro screening toxicity studies conducted at our CRO partner sites. You will act as the primary scientific contact for the Study Director. Job Responsibilities Lead or co-lead novel projects, facilitating collaboration to achieve impactful results aligned with BR goals. Generate innovative ideas to meet new technical requirements and address key scientific questions. Serve as the appointed Study Monitor for outsourced preclinical studies, based on expertise and scientific background, acting as the primary contact for the Study Director at CROs. Oversee study progress, ensuring conduct, recording, and reporting comply with the protocol, GLP regulations, animal welfare policies, and international guidelines. Resolve study-related issues, liaise with internal experts, and ensure timely communication and report delivery. Develop strong working relationships with team members through effective communication. Collaborate with PCS-Operations and PTM to formulate outsourcing strategies. Maintain knowledge of HA regulations (Swiss medic, OECD, FDA) to support GLP toxicology studies. Potentially serve as a part-time PCS PTM. Role Requirements PhD or MVSc/MS/M.Pharm with 7+ years of experience in drug discovery or development, preferably as Study Director or Study Monitor in early preclinical and GLP studies. Deep knowledge of toxicology assays, safety pharmacology, and genotoxicity. Proficiency with techniques and tools used in drug design and development. Excellent communication skills, strong teamwork, and logistical planning abilities. Registration and certification with an International Toxicology register. Why Novartis: Our purpose is to reimagine medicine to improve and extend lives. Join us to be part of this mission. Learn more: Commitment to Diversity and Inclusion: We strive to build an inclusive, diverse work environment reflecting the communities we serve. Connect with Us: Join the Novartis Network to stay informed about career opportunities: Help us create breakthroughs that change patients' lives. Join our community of passionate professionals. Benefits and Rewards: Discover how we support your personal and professional growth: Skills Desired: Animal Models, Bioinformatics, Chemistry, Clinical Research, Collaboration, Communication, Data Analysis, Drug Development, Drug Discovery, Ethics, Flexibility, Influencing Skills, Laboratory, Lifesciences, Medical Research, Patient Care, Pharmaceutics, Problem Solving, Regulatory Compliance, and more.
-Understand complex and critical business problems, formulates integrated analytical approach to mine data sources, employ statistical methods and machine learning algorithms to contribute solving unmet medical needs, discover actionable insights and automate process for reducing effort and time for repeated use. To manage the implementation and adherence to the overall data lifecycle of enterprise data from data acquisition or creation through enrichment, consumption, retention, and retirement, enabling the availability of useful, clean, and accurate data throughout its useful lifecycle. High agility to be able to work across various business domains. Integrate business presentations, smart visualization tools and contextual storytelling to translate findings back to business users with a clear impact. Independently manage budget, ensuring appropriate staffing and coordinating projects within the area. If managing a team: empowers the team and provides guidance and coaching, with initial guidance from more senior leaders supervised. This is usually their first people manager experience. About the Role Our Development Team is guided by our purpose: to reimagine medicine to improve and extend people's lives. To do this, we are optimizing and strengthening our processes and ways of working. We are investing in new technologies and building specific therapeutic area and platform depth and capabilities - all to bring our medicines to patients even faster. We are seeking key talent, like you, to join us and help give people with disease and their families a brighter future to look forward to. Apply today and welcome to where we thrive together! The Role As a Senior Principal Data Scientist in the Medical Affairs Advanced Quantitative Sciences group, you will be responsible for the discussion and implementation of data science methodologies applied to patient-level data (including various clinical, real-world, and biomarker data) across clinical development. You will combine your data science and AI skills and your scientific knowledge in biology or medicine to enrich drug development decisions in close collaboration with internal and external partners. This role offers hybrid working, requiring 3 days per week or 12 days per month in our London Office. Key Accountabilities: You will contribute to planning, execution, interpretation, validation and communication of innovative exploratory analyses and algorithms, to facilitate internal decision making. You will provide technical expertise in data science and (predictive) machine learning/AI to identify opportunities for influencing internal decision making as well as discussions on white papers/regulatory policy. You will perform hands-on analysis of integrated data from clinical trials and the real world to generate fit-for-purpose evidence that is applied to decision making in drug development programs. Your Experience Ph.D. in data science, biostatistics, or other quantitative field (or equivalent). More than 3 years experience in clinical drug development with extensive exposure to clinical trials. Strong knowledge and understanding of statistical methods such as time to event analysis, machine learning, meta-analysis, mixed effect modeling, longitudinal modeling, Bayesian methods, variable selection methods (e.g., lasso, elastic net, random forest), design of clinical trials. Strong programming skills in R and Python. Demonstrated knowledge of data visualization, exploratory analysis, and predictive modeling. Excellent interpersonal and communication skills (verbal and writing). Ability to develop and deliver clear and concise presentations for both internal and external meetings in key decision-making situations. Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting, and inspiring each other. Combining to achieve breakthroughs that change patients' lives. Ready to create a brighter future together? Commitment to Diversity & Inclusion: Novartis is committed to building an outstanding, inclusive work environment and diverse teams' representative of the patients and communities we serve.
Jul 17, 2025
Full time
-Understand complex and critical business problems, formulates integrated analytical approach to mine data sources, employ statistical methods and machine learning algorithms to contribute solving unmet medical needs, discover actionable insights and automate process for reducing effort and time for repeated use. To manage the implementation and adherence to the overall data lifecycle of enterprise data from data acquisition or creation through enrichment, consumption, retention, and retirement, enabling the availability of useful, clean, and accurate data throughout its useful lifecycle. High agility to be able to work across various business domains. Integrate business presentations, smart visualization tools and contextual storytelling to translate findings back to business users with a clear impact. Independently manage budget, ensuring appropriate staffing and coordinating projects within the area. If managing a team: empowers the team and provides guidance and coaching, with initial guidance from more senior leaders supervised. This is usually their first people manager experience. About the Role Our Development Team is guided by our purpose: to reimagine medicine to improve and extend people's lives. To do this, we are optimizing and strengthening our processes and ways of working. We are investing in new technologies and building specific therapeutic area and platform depth and capabilities - all to bring our medicines to patients even faster. We are seeking key talent, like you, to join us and help give people with disease and their families a brighter future to look forward to. Apply today and welcome to where we thrive together! The Role As a Senior Principal Data Scientist in the Medical Affairs Advanced Quantitative Sciences group, you will be responsible for the discussion and implementation of data science methodologies applied to patient-level data (including various clinical, real-world, and biomarker data) across clinical development. You will combine your data science and AI skills and your scientific knowledge in biology or medicine to enrich drug development decisions in close collaboration with internal and external partners. This role offers hybrid working, requiring 3 days per week or 12 days per month in our London Office. Key Accountabilities: You will contribute to planning, execution, interpretation, validation and communication of innovative exploratory analyses and algorithms, to facilitate internal decision making. You will provide technical expertise in data science and (predictive) machine learning/AI to identify opportunities for influencing internal decision making as well as discussions on white papers/regulatory policy. You will perform hands-on analysis of integrated data from clinical trials and the real world to generate fit-for-purpose evidence that is applied to decision making in drug development programs. Your Experience Ph.D. in data science, biostatistics, or other quantitative field (or equivalent). More than 3 years experience in clinical drug development with extensive exposure to clinical trials. Strong knowledge and understanding of statistical methods such as time to event analysis, machine learning, meta-analysis, mixed effect modeling, longitudinal modeling, Bayesian methods, variable selection methods (e.g., lasso, elastic net, random forest), design of clinical trials. Strong programming skills in R and Python. Demonstrated knowledge of data visualization, exploratory analysis, and predictive modeling. Excellent interpersonal and communication skills (verbal and writing). Ability to develop and deliver clear and concise presentations for both internal and external meetings in key decision-making situations. Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting, and inspiring each other. Combining to achieve breakthroughs that change patients' lives. Ready to create a brighter future together? Commitment to Diversity & Inclusion: Novartis is committed to building an outstanding, inclusive work environment and diverse teams' representative of the patients and communities we serve.
Work Schedule Standard (Mon-Fri) Environmental Conditions Office Job Description At Thermo Fisher Scientific, you'll discover meaningful work that makes a positive impact on a global scale. Join our colleagues in bringing our Mission to life - enabling our customers to make the world healthier, cleaner and safer. We provide our teams with the resources needed to achieve individual career goals while taking science a step beyond through research, development and delivery of life-changing therapies. With clinical trials conducted in 100+ countries and ongoing development of novel frameworks for clinical research through our PPD clinical research portfolio, our work spans laboratory, digital and decentralized clinical trial services. Your determination to deliver quality and accuracy will improve health outcomes that people and communities depend on - now and in the future. Location/Division Specific Information Evidera's Patient-Centered Research (PCR) group combines a unique portfolio of scientific fields, including health sciences, psychometrics, epidemiology, psychology, and other. Our work has helped identify and clarify unmet clinical needs, assess burden of illness and evaluate patient outcomes, preference and/or adherence, while supporting promotional and labeling claims on a global scale. The Qualitative Clinical Outcomes Assessment (COA) Lead will manage and grow an established team of scientists within Thermo Fisher Scientific's Patient-Centered Research (PCR) team. The qualitative COA team develops, commercializes and delivers best-in-class qualitative research designed to support global COA development programs across therapeutic areas and for a wide range of clients. This includes patient and caregiver reported outcomes, clinician reported outcomes, observer reported outcomes and performance-based measures. The team draws on many research methods, such as landscape review, concept elicitation, cognitive debriefing, UAT testing, thematic or content analysis, and linguistic validation. The successful candidate will report into the PCR Delivery Lead and work closely with other team leads, such as Quantitative COA, patient-experience data or in-trial research teams. Responsibilities include defining the COA qualitative offering, championing thought leadership to advance science and reputation, driving process innovations, collaborating with the commercial team on business development strategies, serving as point of contact for clients, planning team capacity, staffing of opportunities, offering development opportunities for team members, leading recruitment activities, managing the team pipeline, driving financial success, and ensuring operational excellence. The lead will also support client projects as scientific advisor and/or principal investigator. This exciting role is an essential stakeholder to PCR providing a full suite of services and offerings to facilitate the integration of research-based findings into pharmaceutical and bio-technology usage throughout all phases of drug development for the betterment of the patient experience. Essential Functions: Work with the PCR leadership and other stakeholders (e.g., commercial team) to develop a vision for thought leadership, innovation, marketing and business development strategy of the qualitative COA team Develop and execute the annual team plan in close collaboration with external and internal stakeholders (e.g., marketing, commercial teams) Coordinate response to client RFPs, including managing existing qualitative resources as well as identification of additional resource needs (i.e. recruitment oversight), and reviewing and approving proposals and budget Support staff management including interviewing and selection, professional development, goal setting, performance management and other tasks associated with staff functions Identify business risks and develop mitigation plans Develop and build long-lasting client relationships Provide clients with advice on COA strategy and appropriate scientific solutions Knowledge, Skills and Ability: Proven leadership in applied qualitative research, COA development and COA validation with a passion for quality and continuous scientific innovation Robust understanding of the global regulatory landscape and associated requirements, with the ability to navigate regulatory complexity Demonstrated drive to lead and develop high performance teams, including long-term strategies, annual objective planning, optimal resource allocation, and staff development Ability to attract, develop and retain scientific talent Extensive experience in consulting with a passion for understanding and addressing client needs with carefully selected scientific solutions Demonstrated ability to delegate effectively Advanced understanding of project scoping, budgeting and forecasting with the ability to interpret data with attention to detail Strong interpersonal, organizational, communication and staff management skills and experience required. Tact and sensitivity in matters relating to confidential material Ability to communicate complex information and ideas so others will understand; with the ability to listen to and understand information and ideas presented through spoken words and sentences. Fluent in written and oral English Education and Experience: Master's Degree or higher with 10 years of experience in the field, including publication and at least 3 years of team management experience. Benefits We offer competitive remuneration, annual incentive plan bonus, healthcare, and a range of employee benefits. Thermo Fisher Scientific offers employment with an innovative, forward-thinking organization, and outstanding career and development prospects. We offer an exciting company culture that stands for integrity, intensity, involvement, and innovation! Our Mission is to enable our customers to make the world healthier, cleaner and safer. Watch as our colleagues explain 5 reasons to work with us. As one team of 100,000+ colleagues, we share a common set of values - Integrity, Intensity, Innovation and Involvement - working together to accelerate research, solve complex scientific challenges, drive technological innovation and support patients in need. with PPD, part of Thermo Fisher Scientific, where diverse experiences, backgrounds and perspectives are valued. Apply today! Thermo Fisher Scientific is an EEO/Affirmative Action Employer and does not discriminate on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability or any other legally protected status.
Jul 17, 2025
Full time
Work Schedule Standard (Mon-Fri) Environmental Conditions Office Job Description At Thermo Fisher Scientific, you'll discover meaningful work that makes a positive impact on a global scale. Join our colleagues in bringing our Mission to life - enabling our customers to make the world healthier, cleaner and safer. We provide our teams with the resources needed to achieve individual career goals while taking science a step beyond through research, development and delivery of life-changing therapies. With clinical trials conducted in 100+ countries and ongoing development of novel frameworks for clinical research through our PPD clinical research portfolio, our work spans laboratory, digital and decentralized clinical trial services. Your determination to deliver quality and accuracy will improve health outcomes that people and communities depend on - now and in the future. Location/Division Specific Information Evidera's Patient-Centered Research (PCR) group combines a unique portfolio of scientific fields, including health sciences, psychometrics, epidemiology, psychology, and other. Our work has helped identify and clarify unmet clinical needs, assess burden of illness and evaluate patient outcomes, preference and/or adherence, while supporting promotional and labeling claims on a global scale. The Qualitative Clinical Outcomes Assessment (COA) Lead will manage and grow an established team of scientists within Thermo Fisher Scientific's Patient-Centered Research (PCR) team. The qualitative COA team develops, commercializes and delivers best-in-class qualitative research designed to support global COA development programs across therapeutic areas and for a wide range of clients. This includes patient and caregiver reported outcomes, clinician reported outcomes, observer reported outcomes and performance-based measures. The team draws on many research methods, such as landscape review, concept elicitation, cognitive debriefing, UAT testing, thematic or content analysis, and linguistic validation. The successful candidate will report into the PCR Delivery Lead and work closely with other team leads, such as Quantitative COA, patient-experience data or in-trial research teams. Responsibilities include defining the COA qualitative offering, championing thought leadership to advance science and reputation, driving process innovations, collaborating with the commercial team on business development strategies, serving as point of contact for clients, planning team capacity, staffing of opportunities, offering development opportunities for team members, leading recruitment activities, managing the team pipeline, driving financial success, and ensuring operational excellence. The lead will also support client projects as scientific advisor and/or principal investigator. This exciting role is an essential stakeholder to PCR providing a full suite of services and offerings to facilitate the integration of research-based findings into pharmaceutical and bio-technology usage throughout all phases of drug development for the betterment of the patient experience. Essential Functions: Work with the PCR leadership and other stakeholders (e.g., commercial team) to develop a vision for thought leadership, innovation, marketing and business development strategy of the qualitative COA team Develop and execute the annual team plan in close collaboration with external and internal stakeholders (e.g., marketing, commercial teams) Coordinate response to client RFPs, including managing existing qualitative resources as well as identification of additional resource needs (i.e. recruitment oversight), and reviewing and approving proposals and budget Support staff management including interviewing and selection, professional development, goal setting, performance management and other tasks associated with staff functions Identify business risks and develop mitigation plans Develop and build long-lasting client relationships Provide clients with advice on COA strategy and appropriate scientific solutions Knowledge, Skills and Ability: Proven leadership in applied qualitative research, COA development and COA validation with a passion for quality and continuous scientific innovation Robust understanding of the global regulatory landscape and associated requirements, with the ability to navigate regulatory complexity Demonstrated drive to lead and develop high performance teams, including long-term strategies, annual objective planning, optimal resource allocation, and staff development Ability to attract, develop and retain scientific talent Extensive experience in consulting with a passion for understanding and addressing client needs with carefully selected scientific solutions Demonstrated ability to delegate effectively Advanced understanding of project scoping, budgeting and forecasting with the ability to interpret data with attention to detail Strong interpersonal, organizational, communication and staff management skills and experience required. Tact and sensitivity in matters relating to confidential material Ability to communicate complex information and ideas so others will understand; with the ability to listen to and understand information and ideas presented through spoken words and sentences. Fluent in written and oral English Education and Experience: Master's Degree or higher with 10 years of experience in the field, including publication and at least 3 years of team management experience. Benefits We offer competitive remuneration, annual incentive plan bonus, healthcare, and a range of employee benefits. Thermo Fisher Scientific offers employment with an innovative, forward-thinking organization, and outstanding career and development prospects. We offer an exciting company culture that stands for integrity, intensity, involvement, and innovation! Our Mission is to enable our customers to make the world healthier, cleaner and safer. Watch as our colleagues explain 5 reasons to work with us. As one team of 100,000+ colleagues, we share a common set of values - Integrity, Intensity, Innovation and Involvement - working together to accelerate research, solve complex scientific challenges, drive technological innovation and support patients in need. with PPD, part of Thermo Fisher Scientific, where diverse experiences, backgrounds and perspectives are valued. Apply today! Thermo Fisher Scientific is an EEO/Affirmative Action Employer and does not discriminate on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability or any other legally protected status.
Job Title : Quality Manager - Sterile Services Salary: Highly competitive basic salary, bonuses & company benefits! Location : Bedfordshire SRG is working with a leading sterile pharmaceutical company who has become a leader in specials with an ever-expanding footprint. They are looking for an experienced Quality Manager with a background in sterile manufacturing quality, to lead their newly developed sterile manufacturing facility. This is a management level role with multiple line management responsibilities of 4 quality and release supervisors who are supervising a team of around 25. Responsibilities: Follow, promote, and enforce relevant SOPs, Job Aids, and Company policies and procedures. Ensure that all licences and authorities are maintained and act as the key contact for the MHRA and Home Office. Lead and close any audits performed by the above authorities, or per customer/client. Lead and mentor the direct reports Promote and educate colleagues in GMP and GDP. Personally act as Quality authorisation, sign off in conjunction with the Quality Director. Provide Aseptic Quality input into the Management Review; ensuring outstanding issues are actioned and resolved, reporting to the Board if necessary. Be able to act as a principal signatory for release of aseptically manufactured products. The monitoring and control of the manufacturing environment. The inspection, investigation, and taking of samples to monitor factors that may affect product quality Requirements Recent experience of operating in a similar role is essential, especially of working within a licensed facility or under a section 10 exemption. A formal qualification in science would be an advantage but not required. Demonstrable experience of working autonomously and making decisions. A recognized management qualification is desirable although not essential depending on experience. Strong, up to date, knowledge of Good Manufacturing Practices. SRG are the UK number 1 recruitment company specialising in the science, engineering, clinical, pharmaceutical, food/FMCG, renewable, biotech, chemicals and medical devices sectors. As scientists ourselves, our specialist sector knowledge and our passion are second to none. It's this combination that makes us different. We're committed to providing outstanding temporary, contract and permanent career opportunities of all levels for our candidates and a comprehensive range of expert strategic recruitment services for our clients. If you have a scientific background and this position is not relevant / suitable for you please feel free to get in touch or visit (url removed) to view our other vacancies. Carbon60, Lorien & SRG - The Impellam Group STEM Portfolio are acting as an Employment Business in relation to this vacancy.
Jul 17, 2025
Full time
Job Title : Quality Manager - Sterile Services Salary: Highly competitive basic salary, bonuses & company benefits! Location : Bedfordshire SRG is working with a leading sterile pharmaceutical company who has become a leader in specials with an ever-expanding footprint. They are looking for an experienced Quality Manager with a background in sterile manufacturing quality, to lead their newly developed sterile manufacturing facility. This is a management level role with multiple line management responsibilities of 4 quality and release supervisors who are supervising a team of around 25. Responsibilities: Follow, promote, and enforce relevant SOPs, Job Aids, and Company policies and procedures. Ensure that all licences and authorities are maintained and act as the key contact for the MHRA and Home Office. Lead and close any audits performed by the above authorities, or per customer/client. Lead and mentor the direct reports Promote and educate colleagues in GMP and GDP. Personally act as Quality authorisation, sign off in conjunction with the Quality Director. Provide Aseptic Quality input into the Management Review; ensuring outstanding issues are actioned and resolved, reporting to the Board if necessary. Be able to act as a principal signatory for release of aseptically manufactured products. The monitoring and control of the manufacturing environment. The inspection, investigation, and taking of samples to monitor factors that may affect product quality Requirements Recent experience of operating in a similar role is essential, especially of working within a licensed facility or under a section 10 exemption. A formal qualification in science would be an advantage but not required. Demonstrable experience of working autonomously and making decisions. A recognized management qualification is desirable although not essential depending on experience. Strong, up to date, knowledge of Good Manufacturing Practices. SRG are the UK number 1 recruitment company specialising in the science, engineering, clinical, pharmaceutical, food/FMCG, renewable, biotech, chemicals and medical devices sectors. As scientists ourselves, our specialist sector knowledge and our passion are second to none. It's this combination that makes us different. We're committed to providing outstanding temporary, contract and permanent career opportunities of all levels for our candidates and a comprehensive range of expert strategic recruitment services for our clients. If you have a scientific background and this position is not relevant / suitable for you please feel free to get in touch or visit (url removed) to view our other vacancies. Carbon60, Lorien & SRG - The Impellam Group STEM Portfolio are acting as an Employment Business in relation to this vacancy.
Overview Bruker is enabling scientists and engineers to make breakthrough post-genomic discoveries and develop new applications that improve the quality of human life. Bruker's high performance scientific instruments and high value analytical and diagnostic solutions enable scientists to explore life and materials at molecular, cellular, and microscopic levels. In close cooperation with our customers, Bruker is enabling innovation, improved productivity, and customer success in post-genomic life science molecular and cell biology research, in applied and biopharma applications, in microscopy and nanoanalysis, as well as in industrial and cleantech research, and next-gen semiconductor metrology in support of AI. Bruker offers differentiated, high-value life science and diagnostics systems and solutions in preclinical imaging, clinical phenomics research, proteomics and multiomics, spatial and single-cell biology, functional structural and condensate biology, as well as in clinical microbiology and molecular diagnostics. Bruker currently has an opening for a test field scientist to optically align, test, and improve complete electron microscope systems. This position will primarily be responsible for aligning electron optics, identifying areas of improvement for electron optics, documenting electron optical procedures, ensuring that microscopes in production meet performance specifications, troubleshooting optical and mechanical elements in the full system, and (mostly remotely) servicing electron microscopes at customer sites. The position will also interface with the UK software development team working on streamlining bring-up activities. The role will be principally based in Sheffield, UK. During the first two years of employment, it is expected that the successful candidate will spend extended periods of time at Bruker's Kirkland, Seattle, office to receive detailed training. It is likely that time will be split roughly 50/50 between the UK and Seattle during this period. Responsibilities Perform electron optical alignment on Bruker Nion electron microscopes and develop a deep understanding of the overall system Identify areas of improvement regarding electron optics and collaborate with the design team to improve and develop electron optical components Research electron trajectories to enable a variety of experimental techniques and improve microscope performance and stability Document procedures for microscope bring-up and electron optical alignment Perform remote support for electron optics and perform remote diagnostics on hardware Organize and prioritize schedules to align with customer requirements Coordinate with the production team while performing full system tests to ensure optimal performance on all devices Act as a technical bridge between the Sheffield software development team and Kirkland production and R&D teams Qualifications Required: PhD in physical sciences or engineering related field Familiarity with concepts in electron optics, charged particle physics, and solid-state physics Ability to work independently and manage multiple priorities to meet production deadlines in a customer-focused environment Ability to communicate with testing, design, and production teams, documenting work/tests performed and outstanding needs during the production lifecycle Desire and ability to learn the inner workings of complex scientific instruments and understand how individual components affect the big picture Strong critical thinking and problem-solving skills Desirable: Experience operating and troubleshooting complex scientific instruments Experience operating electron microscopes Python programming experience
Jul 16, 2025
Full time
Overview Bruker is enabling scientists and engineers to make breakthrough post-genomic discoveries and develop new applications that improve the quality of human life. Bruker's high performance scientific instruments and high value analytical and diagnostic solutions enable scientists to explore life and materials at molecular, cellular, and microscopic levels. In close cooperation with our customers, Bruker is enabling innovation, improved productivity, and customer success in post-genomic life science molecular and cell biology research, in applied and biopharma applications, in microscopy and nanoanalysis, as well as in industrial and cleantech research, and next-gen semiconductor metrology in support of AI. Bruker offers differentiated, high-value life science and diagnostics systems and solutions in preclinical imaging, clinical phenomics research, proteomics and multiomics, spatial and single-cell biology, functional structural and condensate biology, as well as in clinical microbiology and molecular diagnostics. Bruker currently has an opening for a test field scientist to optically align, test, and improve complete electron microscope systems. This position will primarily be responsible for aligning electron optics, identifying areas of improvement for electron optics, documenting electron optical procedures, ensuring that microscopes in production meet performance specifications, troubleshooting optical and mechanical elements in the full system, and (mostly remotely) servicing electron microscopes at customer sites. The position will also interface with the UK software development team working on streamlining bring-up activities. The role will be principally based in Sheffield, UK. During the first two years of employment, it is expected that the successful candidate will spend extended periods of time at Bruker's Kirkland, Seattle, office to receive detailed training. It is likely that time will be split roughly 50/50 between the UK and Seattle during this period. Responsibilities Perform electron optical alignment on Bruker Nion electron microscopes and develop a deep understanding of the overall system Identify areas of improvement regarding electron optics and collaborate with the design team to improve and develop electron optical components Research electron trajectories to enable a variety of experimental techniques and improve microscope performance and stability Document procedures for microscope bring-up and electron optical alignment Perform remote support for electron optics and perform remote diagnostics on hardware Organize and prioritize schedules to align with customer requirements Coordinate with the production team while performing full system tests to ensure optimal performance on all devices Act as a technical bridge between the Sheffield software development team and Kirkland production and R&D teams Qualifications Required: PhD in physical sciences or engineering related field Familiarity with concepts in electron optics, charged particle physics, and solid-state physics Ability to work independently and manage multiple priorities to meet production deadlines in a customer-focused environment Ability to communicate with testing, design, and production teams, documenting work/tests performed and outstanding needs during the production lifecycle Desire and ability to learn the inner workings of complex scientific instruments and understand how individual components affect the big picture Strong critical thinking and problem-solving skills Desirable: Experience operating and troubleshooting complex scientific instruments Experience operating electron microscopes Python programming experience
Reporting to: Director of Advanced Analytics, Technical Development Location: London Job Summary Orchard Therapeutics, a Kyowa Kirin company, is a global gene therapy leader focused on transforming the life of patients with rare disorders through innovative gene therapies based on gene-modified hematopoietic stem cell (HSC). Orchard has its global headquarters in London and U.S. headquarters in Boston. The Technical Development (TD) organisation at Orchard is responsible for the development of manufacturing and analytical processes of Orchard's HSC-based gene therapy pipeline which is actively collaborating with internal stakeholders and external CDMOs to develop innovative technical solutions to bridge early-stage, late-stage and commercial product needs. The Principal Scientist, Analytical Development will be primarily responsible for delivering late stage analytical project milestones of specified Orchard development programs in close partnership with technical and regulatory functions within Orchard and at CDMOs. They will also be a member of the CMC team representing Analytics for the assigned project(s). The incumbent will work together with innovator partners in process development as an integrated part of the development programs to provide scientific, technical support for advancing, de-risking and accelerating all stages of product development, including candidate selection. The ideal candidate has demonstrated leadership and knowledge of the development, validation design and execution, implementation, maintenance and improvement of analytical methods as well as the delivery of high-quality regulatory submissions. Responsibilities Implement defined project analytical strategy for the assigned Orchard's late- stage development programs in close partnership with technical and regulatory functions at Orchard and CDMOs. Design analytical method validation strategies for Orchard's programs in support of regulatory filings enabling strong analytical packages and robust control strategies ensuring product quality and compliance with applicable ICH guidelines and global health authority requirements and expectations. Lead the development of breakthrough analytical techniques aiming at achieving enhanced characterization, elucidate safety profile of gene therapies at cellular level and achieve advanced control over manufacturing consistency (e.g., first-in-class rapid assays, single cell analytics). Source, manage, and analyze large amounts of unstructured data via quantitative algorithms and statistical tools to address technical questions and drive program strategies. Serve as a subject matter expert, author and/or review relevant sections of CMC documentation in support of regulatory submissions, amendments as well as interactions with regulatory authorities. Proactively engage in collaboration with internal organisations (e.g. Research, Clinical Development and Operations, Quality, Manufacturing) and external stakeholders (e.g. CDMOs, contract testing labs) including health authorities and industry trade organizations to identify trends and expectations and incorporate them into Orchard's analytical development and control strategies. Actively support inspection readiness activities and associated Health Authority Inspections; ensure quality, regulatory and EHS compliance. Qualify, validate and transfer analytical methods to ensure product quality and compliance with applicable ICH guidelines and FDA/EMA and other global health authority requirements and expectations; and provide technical input into selecting the most appropriate methodology, assay development and design. Support drug product characterization analysis and establishment of cellular gene therapy product CQA and markers that predict clinical efficacy and safety. Provide input into science-based, phase appropriate, and risk-based analytical validation strategy and specification setting to support clinical programs from pivotal phase to commercial registration and managed analytical assays for commercial products. Support the authoring and reviews of quality reports and documentation related to development, characterization and testing of analytical methods, as well as relevant sections of CMC documentation in support of regulatory submissions, dossier amendments as well as interactions with regulatory authorities. Required knowledge 7 years' experience in analytical development in the pharmaceutical industry Deep understanding of analytic techniques with a strong knowledge of the development, validation, implementation, analytical methods as well as the delivery of high-quality regulatory submissions Sophisticated knowledge and experience onstatistics-driven approaches and tools to quality and processunderstandingin thepharmaceuticalindustry Experience in late phase development of Cell and gene therapy, lentiviral vectors, hematopoietic stem cell biology and characterization and/or in vaccines/biologics characterization. Strong working knowledge and interpretation of FDA/EU and ICH regulations and guidelines. Broad and direct experience with regulatory authority inspections, including both FDA and EMA inspections Skills & Abilities Demonstrated technical proficiency, scientific creativity, business acumen, collaboration with others, independent thought and learning agility Able to deliver high quality regulatory submissions Effective communicator and influencer with proven ability to build relationships internally and externally to the organization that enable strong collaboration between all key stakeholders to achieve critical milestones Demonstrated ability to manage and prioritize multiple projects and consistently meet deadlines Excellent problem-solving skills and organizational skills Seeks and analyzes data from a variety of sources to support decisions and align others Comfortable with ambiguity and uncertainty; able to make decisions through complex situations Creates collaborative and trusting relationships internally and with external partners Education Ph.D. in Biotechnologies, Life Sciences, or related field with strong expertise in advanced analytics and data science applied to the development of cell and gene therapies
Jul 16, 2025
Full time
Reporting to: Director of Advanced Analytics, Technical Development Location: London Job Summary Orchard Therapeutics, a Kyowa Kirin company, is a global gene therapy leader focused on transforming the life of patients with rare disorders through innovative gene therapies based on gene-modified hematopoietic stem cell (HSC). Orchard has its global headquarters in London and U.S. headquarters in Boston. The Technical Development (TD) organisation at Orchard is responsible for the development of manufacturing and analytical processes of Orchard's HSC-based gene therapy pipeline which is actively collaborating with internal stakeholders and external CDMOs to develop innovative technical solutions to bridge early-stage, late-stage and commercial product needs. The Principal Scientist, Analytical Development will be primarily responsible for delivering late stage analytical project milestones of specified Orchard development programs in close partnership with technical and regulatory functions within Orchard and at CDMOs. They will also be a member of the CMC team representing Analytics for the assigned project(s). The incumbent will work together with innovator partners in process development as an integrated part of the development programs to provide scientific, technical support for advancing, de-risking and accelerating all stages of product development, including candidate selection. The ideal candidate has demonstrated leadership and knowledge of the development, validation design and execution, implementation, maintenance and improvement of analytical methods as well as the delivery of high-quality regulatory submissions. Responsibilities Implement defined project analytical strategy for the assigned Orchard's late- stage development programs in close partnership with technical and regulatory functions at Orchard and CDMOs. Design analytical method validation strategies for Orchard's programs in support of regulatory filings enabling strong analytical packages and robust control strategies ensuring product quality and compliance with applicable ICH guidelines and global health authority requirements and expectations. Lead the development of breakthrough analytical techniques aiming at achieving enhanced characterization, elucidate safety profile of gene therapies at cellular level and achieve advanced control over manufacturing consistency (e.g., first-in-class rapid assays, single cell analytics). Source, manage, and analyze large amounts of unstructured data via quantitative algorithms and statistical tools to address technical questions and drive program strategies. Serve as a subject matter expert, author and/or review relevant sections of CMC documentation in support of regulatory submissions, amendments as well as interactions with regulatory authorities. Proactively engage in collaboration with internal organisations (e.g. Research, Clinical Development and Operations, Quality, Manufacturing) and external stakeholders (e.g. CDMOs, contract testing labs) including health authorities and industry trade organizations to identify trends and expectations and incorporate them into Orchard's analytical development and control strategies. Actively support inspection readiness activities and associated Health Authority Inspections; ensure quality, regulatory and EHS compliance. Qualify, validate and transfer analytical methods to ensure product quality and compliance with applicable ICH guidelines and FDA/EMA and other global health authority requirements and expectations; and provide technical input into selecting the most appropriate methodology, assay development and design. Support drug product characterization analysis and establishment of cellular gene therapy product CQA and markers that predict clinical efficacy and safety. Provide input into science-based, phase appropriate, and risk-based analytical validation strategy and specification setting to support clinical programs from pivotal phase to commercial registration and managed analytical assays for commercial products. Support the authoring and reviews of quality reports and documentation related to development, characterization and testing of analytical methods, as well as relevant sections of CMC documentation in support of regulatory submissions, dossier amendments as well as interactions with regulatory authorities. Required knowledge 7 years' experience in analytical development in the pharmaceutical industry Deep understanding of analytic techniques with a strong knowledge of the development, validation, implementation, analytical methods as well as the delivery of high-quality regulatory submissions Sophisticated knowledge and experience onstatistics-driven approaches and tools to quality and processunderstandingin thepharmaceuticalindustry Experience in late phase development of Cell and gene therapy, lentiviral vectors, hematopoietic stem cell biology and characterization and/or in vaccines/biologics characterization. Strong working knowledge and interpretation of FDA/EU and ICH regulations and guidelines. Broad and direct experience with regulatory authority inspections, including both FDA and EMA inspections Skills & Abilities Demonstrated technical proficiency, scientific creativity, business acumen, collaboration with others, independent thought and learning agility Able to deliver high quality regulatory submissions Effective communicator and influencer with proven ability to build relationships internally and externally to the organization that enable strong collaboration between all key stakeholders to achieve critical milestones Demonstrated ability to manage and prioritize multiple projects and consistently meet deadlines Excellent problem-solving skills and organizational skills Seeks and analyzes data from a variety of sources to support decisions and align others Comfortable with ambiguity and uncertainty; able to make decisions through complex situations Creates collaborative and trusting relationships internally and with external partners Education Ph.D. in Biotechnologies, Life Sciences, or related field with strong expertise in advanced analytics and data science applied to the development of cell and gene therapies
Location : London (Hammersmith) Reporting to :Director, Viral Vector Development Orchard Therapeutics, a Kyowa Kirin company, is a global gene therapy leader focused on transforming the life of patients with rare disorders through innovative gene therapies based on gene-modified hematopoietic stem cell (HSC). Orchard has its global headquarters in London and U.S. headquarters in Boston. Technical Development sits within Technical Operations at Orchard and is responsible for the development and characterization of Lentiviral Vectors (LVVs) and DS/DP production processes, which meet patient demand for therapeutic products of the best quality. Reporting to the Director, Viral Vector Development, the Principal Scientist, Viral Vector Development, will be responsible for the development of innovative, high-yield processes for production of LVVs for the defined project(s). The candidate will closely interact with other functional groups including analytics, cell process development, CMC and regulatory teams. This role is based in our Hammersmith, London facilities within our global headquarters and will suit candidates who would like to join a global company with a diverse and dynamic work environment that provides opportunities for sustained personal and professional growth. Key Elements and Responsibilities Design, develop and improve upstream and downstream processes for LVVs to deliver robust manufacturing platforms for early and late-stage clinical and commercial development Execute experimental plans, analyse experimental data and write technical reports Provide hands-on technical expertise/scientific guidance to team members and supervision of junior colleagues Contribute to the transfer of improved processes to GMP and assist with oversight of manufacturing activities as required Assist in the reporting, investigation and resolution of deviations encountered during GMP production activities Prepare, review and complete protocols/SOPs, study reports and assist with regulatory submissions Communicate, share and discuss work progress internally and externally Perform landscape scouting to drive continuous improvement in quality, yield and COGs Provide expert review and approval of executed batch, records, test records and associated documentation for release of LVVs and plasmids used in their production. Experience & Knowledge In-depth knowledge of state-of-the-art cell & gene therapy products and available technologies, more specifically regarding viral vectors Minimum of 5 years of experience with development, manufacture and delivery of viral vectors, preferably retro and lentiviral vectors including late phase product development Experience with risk-based approaches, such as Failure Modes and Effects Analysis Demonstrated skills and experience in adherent and suspension cell lines in different culture systems Demonstrated knowledge in designing and developing processes for LVV production and purification Experience in process characterization and validation of the large-scale cGMP production of lentiviral vectors Experience with specialised lab equipment e.g. bioreactors, AKTA, TFF systems, etc Proficiency with MS office, MFCS, SnapGene, Unicorn, e-lab books and other commonly used software is required. Experience with DoE software (s) and statistical analysis would be ideal. Knowledge of FDA, EMA, GMP and ICH regulatory requirements Knowledge of Quality Systems and QBD as they relate to GMP production operations, process optimization and process validation. Knowledge of statistical data analysis Knowledge of plasmid DNA manufacturing would be an asset. Skills and Abilities Demonstrated skills and capability in planning, preparing, executing and reporting of process development and validation activities. Ability to operate in a fast paced, multidisciplinary industrial environment Creativeness, motivation, and troubleshooting skills to solve problems and/or develop new technical capabilities Excellent interpersonal and communication skills Ability to visualize / present data in order to communicate ideas, concepts and results to technical and non-technical audiences. Ability to independently design and appropriately analyse data and provide an interpretation of results Strong organization and planning skills to prioritise work and meet deadlines Education PhD, BSc or equivalent in biotechnology, process development, cell and gene therapy, biological sciences, or other relevant scientific disc
Jul 16, 2025
Full time
Location : London (Hammersmith) Reporting to :Director, Viral Vector Development Orchard Therapeutics, a Kyowa Kirin company, is a global gene therapy leader focused on transforming the life of patients with rare disorders through innovative gene therapies based on gene-modified hematopoietic stem cell (HSC). Orchard has its global headquarters in London and U.S. headquarters in Boston. Technical Development sits within Technical Operations at Orchard and is responsible for the development and characterization of Lentiviral Vectors (LVVs) and DS/DP production processes, which meet patient demand for therapeutic products of the best quality. Reporting to the Director, Viral Vector Development, the Principal Scientist, Viral Vector Development, will be responsible for the development of innovative, high-yield processes for production of LVVs for the defined project(s). The candidate will closely interact with other functional groups including analytics, cell process development, CMC and regulatory teams. This role is based in our Hammersmith, London facilities within our global headquarters and will suit candidates who would like to join a global company with a diverse and dynamic work environment that provides opportunities for sustained personal and professional growth. Key Elements and Responsibilities Design, develop and improve upstream and downstream processes for LVVs to deliver robust manufacturing platforms for early and late-stage clinical and commercial development Execute experimental plans, analyse experimental data and write technical reports Provide hands-on technical expertise/scientific guidance to team members and supervision of junior colleagues Contribute to the transfer of improved processes to GMP and assist with oversight of manufacturing activities as required Assist in the reporting, investigation and resolution of deviations encountered during GMP production activities Prepare, review and complete protocols/SOPs, study reports and assist with regulatory submissions Communicate, share and discuss work progress internally and externally Perform landscape scouting to drive continuous improvement in quality, yield and COGs Provide expert review and approval of executed batch, records, test records and associated documentation for release of LVVs and plasmids used in their production. Experience & Knowledge In-depth knowledge of state-of-the-art cell & gene therapy products and available technologies, more specifically regarding viral vectors Minimum of 5 years of experience with development, manufacture and delivery of viral vectors, preferably retro and lentiviral vectors including late phase product development Experience with risk-based approaches, such as Failure Modes and Effects Analysis Demonstrated skills and experience in adherent and suspension cell lines in different culture systems Demonstrated knowledge in designing and developing processes for LVV production and purification Experience in process characterization and validation of the large-scale cGMP production of lentiviral vectors Experience with specialised lab equipment e.g. bioreactors, AKTA, TFF systems, etc Proficiency with MS office, MFCS, SnapGene, Unicorn, e-lab books and other commonly used software is required. Experience with DoE software (s) and statistical analysis would be ideal. Knowledge of FDA, EMA, GMP and ICH regulatory requirements Knowledge of Quality Systems and QBD as they relate to GMP production operations, process optimization and process validation. Knowledge of statistical data analysis Knowledge of plasmid DNA manufacturing would be an asset. Skills and Abilities Demonstrated skills and capability in planning, preparing, executing and reporting of process development and validation activities. Ability to operate in a fast paced, multidisciplinary industrial environment Creativeness, motivation, and troubleshooting skills to solve problems and/or develop new technical capabilities Excellent interpersonal and communication skills Ability to visualize / present data in order to communicate ideas, concepts and results to technical and non-technical audiences. Ability to independently design and appropriately analyse data and provide an interpretation of results Strong organization and planning skills to prioritise work and meet deadlines Education PhD, BSc or equivalent in biotechnology, process development, cell and gene therapy, biological sciences, or other relevant scientific disc
Where curiosity meets purpose-join us in shaping the future of science. Proclinical is seeking a Principal Biophysicist/Biophysical Scientist to join a dynamic Drug Discovery team based in Cambridge, UK. This role focuses on designing and developing biophysical assays to characterize cancer targets at the molecular level, with the goal of advancing novel cancer treatments. You will play a key role in implementing innovative technologies and collaborating with industry and academic partners to drive therapeutic innovation. Responsibilities: Design and develop physiologically relevant biophysical assays to characterize cancer targets. Profile structure-binding and structure-kinetic relationships of small molecules and antibodies. Characterize mechanisms of action to inform dose prediction and clinical efficacy. Stay updated on cutting-edge biophysical techniques and implement new technologies. Lead assay development for a range of target classes. Provide scientific leadership and strategic direction within the Drug Discovery team. Collaborate with internal teams and external partners to progress projects from idea to pre-clinical candidate. Key Skills and Requirements: Background in biophysics or a related discipline (BSc, MSc, or PhD preferred; relevant experience may substitute for education). Expertise in dissecting enzyme and small molecule inhibitor mechanisms using biophysical methods. Practical experience with established biophysical techniques such as SPR, ITC, MST, and DSF-TSA. Familiarity with emerging technologies like GCI and Spectral Shift. Proven track record in assay development across various target classes. Strong scientific leadership skills and ability to provide strategic direction. Recognized external reputation through publications, conference presentations, or professional networks. If you are having difficulty in applying or if you have any questions, please contact Ruhee Saleh at . Apply Now: If you are interested in applying to this exciting opportunity, then please click 'Apply' or to speak to one of our specialists please request a call back at the top of this page. Proclinical is a leading life sciences recruiter focused on finding exceptional people and matching them with the finest positions across the globe. Proclinical is acting as an Employment Agency in relation to this vacancy. By submitting this application, you confirm that you've read and understood our privacy policy, which informs you how we process and safeguard your data -
Jul 16, 2025
Full time
Where curiosity meets purpose-join us in shaping the future of science. Proclinical is seeking a Principal Biophysicist/Biophysical Scientist to join a dynamic Drug Discovery team based in Cambridge, UK. This role focuses on designing and developing biophysical assays to characterize cancer targets at the molecular level, with the goal of advancing novel cancer treatments. You will play a key role in implementing innovative technologies and collaborating with industry and academic partners to drive therapeutic innovation. Responsibilities: Design and develop physiologically relevant biophysical assays to characterize cancer targets. Profile structure-binding and structure-kinetic relationships of small molecules and antibodies. Characterize mechanisms of action to inform dose prediction and clinical efficacy. Stay updated on cutting-edge biophysical techniques and implement new technologies. Lead assay development for a range of target classes. Provide scientific leadership and strategic direction within the Drug Discovery team. Collaborate with internal teams and external partners to progress projects from idea to pre-clinical candidate. Key Skills and Requirements: Background in biophysics or a related discipline (BSc, MSc, or PhD preferred; relevant experience may substitute for education). Expertise in dissecting enzyme and small molecule inhibitor mechanisms using biophysical methods. Practical experience with established biophysical techniques such as SPR, ITC, MST, and DSF-TSA. Familiarity with emerging technologies like GCI and Spectral Shift. Proven track record in assay development across various target classes. Strong scientific leadership skills and ability to provide strategic direction. Recognized external reputation through publications, conference presentations, or professional networks. If you are having difficulty in applying or if you have any questions, please contact Ruhee Saleh at . Apply Now: If you are interested in applying to this exciting opportunity, then please click 'Apply' or to speak to one of our specialists please request a call back at the top of this page. Proclinical is a leading life sciences recruiter focused on finding exceptional people and matching them with the finest positions across the globe. Proclinical is acting as an Employment Agency in relation to this vacancy. By submitting this application, you confirm that you've read and understood our privacy policy, which informs you how we process and safeguard your data -
Site Name: UK - London - New Oxford Street, Belgium-Wavre Posted Date: Jul 9 2025 We are seeking a dedicated professional to support Pharmacovigilance Operations (PV Ops) with a primary focus on Individual Case Safety Report (ICSR) Management. Depending on experience of successful candidate, it will be either Principal Scientist, PV Ops or Manager, PV Ops. This role involves overseeing processing ICSRs and case processing coding conventions. The successful candidate will interact with Local Operating Companies (LOCs) and oversee functional vendors for market authorizations, withdrawals, and PAC awareness. Additionally, the role includes managing clinical trial/program interactions, from setup and maintenance to closeout, and configuring Argus for submissions to various destinations, such as regulatory authorities, partners, Clinical Research Organisations (CROs), LOCs, and clinical operations. The position holder will ensure all activities align with GSK standards and regulatory timelines, fostering robust processes for effective PV operations and vendor oversight. We create a place where people can grow, be their best, be safe, and feel welcome, valued and included. We offer a competitive salary, an annual bonus based on company performance, healthcare and wellbeing programmes, pension plan membership, and shares and savings programme. We embrace modern work practises; our Performance with Choice programme offers a hybrid working model, empowering you to find the optimal balance between remote and in-office work. Discover more about our company wide benefits and life at GSK on our webpage Life at GSK GSK In this role you will Applicable to both Principal Scientist and Manager level Contribute to all aspects of case handling activities from case receipt to expedited reporting and collaborate with stakeholders (i.e., the Safety Evaluation and Risk Management (SERM) group, local operating companies (LOCs) and clinical operations/sciences) to ensure that documentation and processes are in place to achieve successful recording and reporting of safety data during the life cycle of a clinical trial and marketed product. Work across a complex matrix environment to drive high-quality delivery of case management activities that comply with internal standards and external regulatory requirements; where problems or issues are identified, facilitate investigation into root cause and create corrective/preventative actions (CAPAs). Escalate identified problems or issues to the appropriate Management Personnel with PV Operations. Generate new ideas and proposals for global implementation; contribute to advancement of PV Operations methodology and processes. Ensures third parties/vendors develop and implement robust processes to support quality-driven organization. Manager, PV Ops: Support Scientists with enhancement of knowledge and skills for ICSR Management activities Lead and oversee Clinical Trial and/or post-Marketed study (PMS) related activities e.g. protocol review, Safety Management Plan review, study/program set-up, reconciliation, end of study unblinding, etc.; supports case management activities for spontaneous event reports. Act as a global PV Operations Leader for process discussions, including queries on strategy/policy related decisions; authors or provides significant input into the development of written standards. Generate new ideas and proposals for global implementation; contributes to advancement of ICSR management/ program/clinical trial set up/maintenance methodology and processes. Act as a PV Ops leader for process discussions and changes, reinforcing the principal of SPADM (single point accountability decision making) Why you? Basic Qualifications & Skills: We are looking for professionals with these required skills to achieve our goals: Degree in life sciences or medically related field or previous experience equating to educational requirements Project management experience Ability to map processes and author written standards Knowledge and experience with pharmacovigilance systems Preferred Qualifications & Skills: Please note the following skills are not necessary, just preferred, if you do not have them, please still apply: Proven experience developing and delivering high-quality training Experience of providing mentoring to other staff Closing Date for Applications - 23rd of July 2025 (COB) Please take a copy of the Job Description, as this will not be available post closure of the advert. When applying for this role, please use the 'cover letter' of the online application or your CV to describe how you meet the competencies for this role, as outlined in the job requirements above. The information that you have provided in your cover letter and CV will be used to assess your application. At GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people over the next 10 years. R&D is committed to discovering and delivering transformational vaccines and medicines to prevent and change the course of disease. Science and technology are coming together in a way they never have before, and we have strong tech-enabled capabilities that allow us to build a deeper understanding of the patient, human biology and disease mechanisms, and transform medical discovery. We are revolutionising the way we do R&D. We're uniting science, technology and talent to get ahead of disease together. Find out more: Our approach to R&D . Why GSK? Uniting science, technology and talent to get ahead of disease together. GSK is a global biopharma company with a special purpose - to unite science, technology and talent to get ahead of disease together - so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns - as an organisation where people can thrive. We prevent and treat disease with vaccines, specialty and general medicines. We focus on the science of the immune system and the use of new platform and data technologies, investing in four core therapeutic areas (infectious diseases, HIV, respiratory/ immunology and oncology). Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it's also about making GSK a place where people can thrive. We want GSK to be a place where people feel inspired, encouraged and challenged to be the best they can be. A place where they can be themselves - feeling welcome, valued, and included. Where they can keep growing and look after their wellbeing. So, if you share our ambition, join us at this exciting moment in our journey to get Ahead Together. GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law. We believe in an agile working culture for all our roles. If flexibility is important to you, we encourage you to explore with our hiring team what the opportunities are. Should you require any adjustments to our process to assist you in demonstrating your strengths and capabilities contact us on or . The helpline is available from 8.30am to 12.00 noon Monday to Friday, during bank holidays these times and days may vary. Please note should your enquiry not relate to adjustments, we will not be able to support you through these channels. However, we have created a UK Recruitment FAQ guide. Click the link and scroll to the Careers Section where you will find answers to multiple questions we receive Important notice to Employment businesses/ Agencies GSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK's commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site. Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSK's compliance to all federal and state US Transparency requirements. For more information, please visit the Centers for Medicare and Medicaid Services (CMS) website at
Jul 16, 2025
Full time
Site Name: UK - London - New Oxford Street, Belgium-Wavre Posted Date: Jul 9 2025 We are seeking a dedicated professional to support Pharmacovigilance Operations (PV Ops) with a primary focus on Individual Case Safety Report (ICSR) Management. Depending on experience of successful candidate, it will be either Principal Scientist, PV Ops or Manager, PV Ops. This role involves overseeing processing ICSRs and case processing coding conventions. The successful candidate will interact with Local Operating Companies (LOCs) and oversee functional vendors for market authorizations, withdrawals, and PAC awareness. Additionally, the role includes managing clinical trial/program interactions, from setup and maintenance to closeout, and configuring Argus for submissions to various destinations, such as regulatory authorities, partners, Clinical Research Organisations (CROs), LOCs, and clinical operations. The position holder will ensure all activities align with GSK standards and regulatory timelines, fostering robust processes for effective PV operations and vendor oversight. We create a place where people can grow, be their best, be safe, and feel welcome, valued and included. We offer a competitive salary, an annual bonus based on company performance, healthcare and wellbeing programmes, pension plan membership, and shares and savings programme. We embrace modern work practises; our Performance with Choice programme offers a hybrid working model, empowering you to find the optimal balance between remote and in-office work. Discover more about our company wide benefits and life at GSK on our webpage Life at GSK GSK In this role you will Applicable to both Principal Scientist and Manager level Contribute to all aspects of case handling activities from case receipt to expedited reporting and collaborate with stakeholders (i.e., the Safety Evaluation and Risk Management (SERM) group, local operating companies (LOCs) and clinical operations/sciences) to ensure that documentation and processes are in place to achieve successful recording and reporting of safety data during the life cycle of a clinical trial and marketed product. Work across a complex matrix environment to drive high-quality delivery of case management activities that comply with internal standards and external regulatory requirements; where problems or issues are identified, facilitate investigation into root cause and create corrective/preventative actions (CAPAs). Escalate identified problems or issues to the appropriate Management Personnel with PV Operations. Generate new ideas and proposals for global implementation; contribute to advancement of PV Operations methodology and processes. Ensures third parties/vendors develop and implement robust processes to support quality-driven organization. Manager, PV Ops: Support Scientists with enhancement of knowledge and skills for ICSR Management activities Lead and oversee Clinical Trial and/or post-Marketed study (PMS) related activities e.g. protocol review, Safety Management Plan review, study/program set-up, reconciliation, end of study unblinding, etc.; supports case management activities for spontaneous event reports. Act as a global PV Operations Leader for process discussions, including queries on strategy/policy related decisions; authors or provides significant input into the development of written standards. Generate new ideas and proposals for global implementation; contributes to advancement of ICSR management/ program/clinical trial set up/maintenance methodology and processes. Act as a PV Ops leader for process discussions and changes, reinforcing the principal of SPADM (single point accountability decision making) Why you? Basic Qualifications & Skills: We are looking for professionals with these required skills to achieve our goals: Degree in life sciences or medically related field or previous experience equating to educational requirements Project management experience Ability to map processes and author written standards Knowledge and experience with pharmacovigilance systems Preferred Qualifications & Skills: Please note the following skills are not necessary, just preferred, if you do not have them, please still apply: Proven experience developing and delivering high-quality training Experience of providing mentoring to other staff Closing Date for Applications - 23rd of July 2025 (COB) Please take a copy of the Job Description, as this will not be available post closure of the advert. When applying for this role, please use the 'cover letter' of the online application or your CV to describe how you meet the competencies for this role, as outlined in the job requirements above. The information that you have provided in your cover letter and CV will be used to assess your application. At GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people over the next 10 years. R&D is committed to discovering and delivering transformational vaccines and medicines to prevent and change the course of disease. Science and technology are coming together in a way they never have before, and we have strong tech-enabled capabilities that allow us to build a deeper understanding of the patient, human biology and disease mechanisms, and transform medical discovery. We are revolutionising the way we do R&D. We're uniting science, technology and talent to get ahead of disease together. Find out more: Our approach to R&D . Why GSK? Uniting science, technology and talent to get ahead of disease together. GSK is a global biopharma company with a special purpose - to unite science, technology and talent to get ahead of disease together - so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns - as an organisation where people can thrive. We prevent and treat disease with vaccines, specialty and general medicines. We focus on the science of the immune system and the use of new platform and data technologies, investing in four core therapeutic areas (infectious diseases, HIV, respiratory/ immunology and oncology). Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it's also about making GSK a place where people can thrive. We want GSK to be a place where people feel inspired, encouraged and challenged to be the best they can be. A place where they can be themselves - feeling welcome, valued, and included. Where they can keep growing and look after their wellbeing. So, if you share our ambition, join us at this exciting moment in our journey to get Ahead Together. GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law. We believe in an agile working culture for all our roles. If flexibility is important to you, we encourage you to explore with our hiring team what the opportunities are. Should you require any adjustments to our process to assist you in demonstrating your strengths and capabilities contact us on or . The helpline is available from 8.30am to 12.00 noon Monday to Friday, during bank holidays these times and days may vary. Please note should your enquiry not relate to adjustments, we will not be able to support you through these channels. However, we have created a UK Recruitment FAQ guide. Click the link and scroll to the Careers Section where you will find answers to multiple questions we receive Important notice to Employment businesses/ Agencies GSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK's commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site. Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSK's compliance to all federal and state US Transparency requirements. For more information, please visit the Centers for Medicare and Medicaid Services (CMS) website at
Principal Scientist - Biocompatibility & Product Development Location: Witney, Oxfordshire ABOUT OUR DIABETES CARE DIVISION: Abbott is about the power of health. For more than 135 years, Abbott has been helping people reach their potential - because better health allows people and communities to achieve more. With a diverse, global network serving customers in more than 160 countries, we create new solutions - across the spectrum of health, around the world, for all stages of life. Whether it's next-generation diagnostics, life-changing devices, science-based nutrition, or novel reformulations, we are advancing some of the most innovative and revolutionary technologies in healthcare, helping people live their best lives through better health. World Leader in Glucose Monitoring, Abbott Diabetes Care designs, develops and manufactures glucose monitoring systems for use in both home and hospital settings. We have a Centre of Excellence in Witney for the development and manufacture of electrodes and biosensors used by patients and healthcare professionals for the day-to-day management of diabetes. The site has been instrumental in the research, development and manufacture of the FreeStyle Libre Flash Glucose Monitoring System as well as exciting developments in the Libre family including FreeStyle Libre 2, FreeStyle Libre 3 and the Libre Sense system. We are passionate about doing work that improves the quality of people's lives. THE OPPORTUNITY: We currently have an exciting opportunity for aBiocompatibility specialist to join our R&D team to provide expertise across the ADC product range, supporting regulatory submissions for new products, on-market changes for existing products, as well and ensuring compliance with regulations and awareness of emerging regulations. Role will be Witney site based working cross functionally including Regulatory, Quality, Clinical Affairs & Research & Development organisations worldwide. ABOUT YOU: The ideal candidate will be a proactive individual, comfortable working in a fast-paced, changing environment with the ability to make decisions. You will bring excellent communication and interpersonal skills,with prior experience of a role working to maintain compliance with biocompatibility standards. You will be degree qualified, and bring experience in biocompatibility, additional knowledge of materials science, analytical chemistry or toxicology would be beneficial. Experience of working within medical devices is beneficial. Responsibilities include: Assist with strategic decision making with respect to biocompatibility - being an Subject Matter Expert in this area. Ensuring compliance for both in-development products and on-market products to existing standards and ADCs design control process. Oversight of any testing/data collection required, including working with and maintaining effective (technical) relationships with third party suppliers Ensuring future compliance - maintaining awareness of upcoming changes to standards and associated test methodologies and being future thinking. WHAT WE OFFER: At Abbott, you will be part of a dynamic team that is making a real difference in diabetes care. You will have the opportunity to work on cutting-edge technology and contribute to innovative solutions that improve lives. We offer a collaborative work environment, opportunities for professional growth, and the chance to be part of a company that values scientific excellence and innovation. In addition to a competitive salary, Abbott offers a highly attractive benefits package which includes a defined-contribution pension scheme, a share ownership scheme, private healthcare, life assurance, and a flexible benefits scheme which you can tailor to your own requirements. We like to help our employees live life to the fullest, and therefore we offer a range of optional initiatives for you to get involved in, including onsite allotments, couch to 5k campaigns, bee keeping, yoga and more! APPLY NOW: If you are passionate about electrochemistry and eager to contribute to ground-breaking research and development, we invite you to apply for this exciting opportunity. Join us in advancing diabetes care and making a positive impact on the world.
Jul 16, 2025
Full time
Principal Scientist - Biocompatibility & Product Development Location: Witney, Oxfordshire ABOUT OUR DIABETES CARE DIVISION: Abbott is about the power of health. For more than 135 years, Abbott has been helping people reach their potential - because better health allows people and communities to achieve more. With a diverse, global network serving customers in more than 160 countries, we create new solutions - across the spectrum of health, around the world, for all stages of life. Whether it's next-generation diagnostics, life-changing devices, science-based nutrition, or novel reformulations, we are advancing some of the most innovative and revolutionary technologies in healthcare, helping people live their best lives through better health. World Leader in Glucose Monitoring, Abbott Diabetes Care designs, develops and manufactures glucose monitoring systems for use in both home and hospital settings. We have a Centre of Excellence in Witney for the development and manufacture of electrodes and biosensors used by patients and healthcare professionals for the day-to-day management of diabetes. The site has been instrumental in the research, development and manufacture of the FreeStyle Libre Flash Glucose Monitoring System as well as exciting developments in the Libre family including FreeStyle Libre 2, FreeStyle Libre 3 and the Libre Sense system. We are passionate about doing work that improves the quality of people's lives. THE OPPORTUNITY: We currently have an exciting opportunity for aBiocompatibility specialist to join our R&D team to provide expertise across the ADC product range, supporting regulatory submissions for new products, on-market changes for existing products, as well and ensuring compliance with regulations and awareness of emerging regulations. Role will be Witney site based working cross functionally including Regulatory, Quality, Clinical Affairs & Research & Development organisations worldwide. ABOUT YOU: The ideal candidate will be a proactive individual, comfortable working in a fast-paced, changing environment with the ability to make decisions. You will bring excellent communication and interpersonal skills,with prior experience of a role working to maintain compliance with biocompatibility standards. You will be degree qualified, and bring experience in biocompatibility, additional knowledge of materials science, analytical chemistry or toxicology would be beneficial. Experience of working within medical devices is beneficial. Responsibilities include: Assist with strategic decision making with respect to biocompatibility - being an Subject Matter Expert in this area. Ensuring compliance for both in-development products and on-market products to existing standards and ADCs design control process. Oversight of any testing/data collection required, including working with and maintaining effective (technical) relationships with third party suppliers Ensuring future compliance - maintaining awareness of upcoming changes to standards and associated test methodologies and being future thinking. WHAT WE OFFER: At Abbott, you will be part of a dynamic team that is making a real difference in diabetes care. You will have the opportunity to work on cutting-edge technology and contribute to innovative solutions that improve lives. We offer a collaborative work environment, opportunities for professional growth, and the chance to be part of a company that values scientific excellence and innovation. In addition to a competitive salary, Abbott offers a highly attractive benefits package which includes a defined-contribution pension scheme, a share ownership scheme, private healthcare, life assurance, and a flexible benefits scheme which you can tailor to your own requirements. We like to help our employees live life to the fullest, and therefore we offer a range of optional initiatives for you to get involved in, including onsite allotments, couch to 5k campaigns, bee keeping, yoga and more! APPLY NOW: If you are passionate about electrochemistry and eager to contribute to ground-breaking research and development, we invite you to apply for this exciting opportunity. Join us in advancing diabetes care and making a positive impact on the world.
Manufacturing Scientist / Process Development Scientist Reporting to: Senior Manufacturing Scientist / Principal Scientist Hours of Work: Rotating shifts weekly with a shift allowance paid Shift 1. 6am - 2pm - Monday to Thursday and 6am - 3pm Friday. Shift 2. 1pm - 9.30pm Monday to Thursday. However, you may be required to work flexible around these core hours as necessary in order to meet the demands of the business. The Role Reporting into the Senior Manufacturing Scientist or Principal Scientist position, the role of Manufacturing Scientists / Process Development Scientists will undertake clinical manufacturing or technical transfer / scale up activities to achieve project goals and milestones, and to meet project targets. Dosage forms include, but are not limited to, tablets, capsules, liquids, inhalers, and nasal devices. Activities will be focused on clinical and technical transfer / scale up manufacturing activities but will also include equipment and facility cleaning. Main duties and responsibilities: Undertake manufacturing activities as directed, using the company's processes safely to meet batch production requirements. Operate various equipment involved in the manufacturing and testing of products, at various batch Complete all documentation accurately in full to support manufacturing activities including logbooks, batch records, operational records and log cards. Manage and maintain equipment and the manufacturing facility, including cleaning Support the warehouse team in the receipt and booking in of raw materials and samples where Work and adhere to the Upperton Quality Management General role responsibilities: Understand & follow the company's Health & Safety Policy & Procedures & report all accidents or any unsafe conditions in the work place Ensure training has been received before undertaking specific duties & that all training is recorded in training records Adhere to all HR policies & procedures, specifically including all absence policies and procedures Communicate within your own department to ensure that all relevant information is forwarded to the appropriate personnel on a regular & timely basis Essential skills and experience: Educated to degree level or higher in a related scientific/technical discipline or have relevant work Excellent communication skills, both written and Excellent organisation skills with strong attention to Proficiency in the use of Microsoft Office Ability to effectively contribute within a team environment and work on own Strong focus on quality and safety Apply. Name First Last Email Phone How did you find out about this position? Current Employee Job Website Search Engine Social Media Upload your CV Click or drag a file to this area to upload. Upload your covering letter Click or drag a file to this area to upload.
Jul 16, 2025
Full time
Manufacturing Scientist / Process Development Scientist Reporting to: Senior Manufacturing Scientist / Principal Scientist Hours of Work: Rotating shifts weekly with a shift allowance paid Shift 1. 6am - 2pm - Monday to Thursday and 6am - 3pm Friday. Shift 2. 1pm - 9.30pm Monday to Thursday. However, you may be required to work flexible around these core hours as necessary in order to meet the demands of the business. The Role Reporting into the Senior Manufacturing Scientist or Principal Scientist position, the role of Manufacturing Scientists / Process Development Scientists will undertake clinical manufacturing or technical transfer / scale up activities to achieve project goals and milestones, and to meet project targets. Dosage forms include, but are not limited to, tablets, capsules, liquids, inhalers, and nasal devices. Activities will be focused on clinical and technical transfer / scale up manufacturing activities but will also include equipment and facility cleaning. Main duties and responsibilities: Undertake manufacturing activities as directed, using the company's processes safely to meet batch production requirements. Operate various equipment involved in the manufacturing and testing of products, at various batch Complete all documentation accurately in full to support manufacturing activities including logbooks, batch records, operational records and log cards. Manage and maintain equipment and the manufacturing facility, including cleaning Support the warehouse team in the receipt and booking in of raw materials and samples where Work and adhere to the Upperton Quality Management General role responsibilities: Understand & follow the company's Health & Safety Policy & Procedures & report all accidents or any unsafe conditions in the work place Ensure training has been received before undertaking specific duties & that all training is recorded in training records Adhere to all HR policies & procedures, specifically including all absence policies and procedures Communicate within your own department to ensure that all relevant information is forwarded to the appropriate personnel on a regular & timely basis Essential skills and experience: Educated to degree level or higher in a related scientific/technical discipline or have relevant work Excellent communication skills, both written and Excellent organisation skills with strong attention to Proficiency in the use of Microsoft Office Ability to effectively contribute within a team environment and work on own Strong focus on quality and safety Apply. Name First Last Email Phone How did you find out about this position? Current Employee Job Website Search Engine Social Media Upload your CV Click or drag a file to this area to upload. Upload your covering letter Click or drag a file to this area to upload.
Fulfil your potential in hospitals that make history: Charing Cross, Hammersmith, St Mary's, Queen Charlotte's & Chelsea and Western Eye. With five world-renowned hospitals, Imperial College Healthcare NHS Trust is full of opportunity if you are looking to develop your healthcare career. We are an NHS Trust of approximately 16,000 people, providing care for over a million and a half patients from north west London and beyond every year. We have a rich heritage and an ambitious vision for the future of our patients and local communities. With our partners, Imperial College London, and The Royal Marsden NHS Foundation Trust, we form Imperial College Academic Health Science Centre, one of 6 academic health science centres in the UK, working to ensure the rapid translation of research for better patient care and excellence in education. We are proud of our heritage in innovation and we are early adopters of new insights in technologies, techniques and treatments for improving health. Job overview Join us as a Principal Magnetic Resonance Physicist on a fixed-term basis to cover maternity leave at Imperial College Healthcare NHS Trust. Based across our hospital sites, you'll provide expert MR physics support and MR safety advice across the Trust and external service partners. We're looking for an HCPC registered, experienced clinical scientist with the confidence to work autonomously and collaboratively. Main duties of the job You will be involved in the delivery of expert scientific and technical support for MRI across Imperial College Healthcare NHS Trust and its external partners. Acting as a senior member of the MR physics team, you'll be responsible for overseeing MR quality assurance programmes, troubleshooting system issues, supporting procurement, and optimising clinical protocols. You will act as a recognised Magnetic Resonance Safety Expert (MRSE), providing high-level safety advice and guidance to radiographers, radiologists, and other clinical staff. You'll also play a vital role in teaching and training STP trainees, junior staff, and postgraduate students. This role requires strong communication, advanced problem-solving skills, and the ability to manage complex projects independently while working collaboratively within a multidisciplinary team. Working for our organisation At Imperial College Healthcare you can achieve extraordinary things with extraordinary people, working with leading clinicians pushing boundaries in patient care. Become part of a vibrant team living our values - expert, kind, collaborative and aspirational. You'll get an experience like no other and will fast forward your career. Benefits include career development, flexible working and wellbeing, staff recognition scheme. Make use of optional benefits including Cycle to Work, car lease schemes, season ticket loan or membership options for onsite leisure facilities. We are committed to equal opportunities and improving the working lives of our staff and will consider applications to work flexibly, part time or job share. Please talk to us at interview. . Detailed job description and main responsibilities The full job description provides an overview of the key tasks and responsibilities of the role and the person specification outlines the qualifications, skills, experience and knowledge required. For both overviews please view the Job Description attachment with the job advert. Person specification Education Honours Degree in a Physical Science MSc in Medical Physics or equivalent subject or equivalent experience Registration with the Health and Care Professions Council (HCPC) Advanced professional training in magnetic resonance physics or equivalent 1st or 2nd class honours degree PhD in a relevant subject Skills Proven competence in understanding and application of MR physics and safety Specialist knowledge and understanding of regulations, recommendations and guidelines Self-motivated/ability for problem solving and decision making Able to work independently providing specialist advice to the Trust and SLA customers Experience Significant experience in application of MR physics in a clinical environment Specialist experience in MR systems, image acquisition and image processing Experience in giving responsible MR safety advice Experience in teaching and training junior staff members and STP trainees Please ensure you check your emails regularly as this is how we will communicate with you throughout the recruitment process. If you are shortlisted you will be contacted by email and text message (if you provide a mobile contact number). Employer certification / accreditation badges You must have appropriate UK professional registration. The postholder will have access to vulnerable people in the course of their normal duties and as such this post is subject to the Rehabilitation of Offenders Act 1974 (Exceptions) Order 1975 (Amendment) (England and Wales) Order 2020 and as such it will be necessary for a submission for Disclosure to be made to the Disclosure and Barring Service to check for any previous criminal convictions.
Jul 16, 2025
Full time
Fulfil your potential in hospitals that make history: Charing Cross, Hammersmith, St Mary's, Queen Charlotte's & Chelsea and Western Eye. With five world-renowned hospitals, Imperial College Healthcare NHS Trust is full of opportunity if you are looking to develop your healthcare career. We are an NHS Trust of approximately 16,000 people, providing care for over a million and a half patients from north west London and beyond every year. We have a rich heritage and an ambitious vision for the future of our patients and local communities. With our partners, Imperial College London, and The Royal Marsden NHS Foundation Trust, we form Imperial College Academic Health Science Centre, one of 6 academic health science centres in the UK, working to ensure the rapid translation of research for better patient care and excellence in education. We are proud of our heritage in innovation and we are early adopters of new insights in technologies, techniques and treatments for improving health. Job overview Join us as a Principal Magnetic Resonance Physicist on a fixed-term basis to cover maternity leave at Imperial College Healthcare NHS Trust. Based across our hospital sites, you'll provide expert MR physics support and MR safety advice across the Trust and external service partners. We're looking for an HCPC registered, experienced clinical scientist with the confidence to work autonomously and collaboratively. Main duties of the job You will be involved in the delivery of expert scientific and technical support for MRI across Imperial College Healthcare NHS Trust and its external partners. Acting as a senior member of the MR physics team, you'll be responsible for overseeing MR quality assurance programmes, troubleshooting system issues, supporting procurement, and optimising clinical protocols. You will act as a recognised Magnetic Resonance Safety Expert (MRSE), providing high-level safety advice and guidance to radiographers, radiologists, and other clinical staff. You'll also play a vital role in teaching and training STP trainees, junior staff, and postgraduate students. This role requires strong communication, advanced problem-solving skills, and the ability to manage complex projects independently while working collaboratively within a multidisciplinary team. Working for our organisation At Imperial College Healthcare you can achieve extraordinary things with extraordinary people, working with leading clinicians pushing boundaries in patient care. Become part of a vibrant team living our values - expert, kind, collaborative and aspirational. You'll get an experience like no other and will fast forward your career. Benefits include career development, flexible working and wellbeing, staff recognition scheme. Make use of optional benefits including Cycle to Work, car lease schemes, season ticket loan or membership options for onsite leisure facilities. We are committed to equal opportunities and improving the working lives of our staff and will consider applications to work flexibly, part time or job share. Please talk to us at interview. . Detailed job description and main responsibilities The full job description provides an overview of the key tasks and responsibilities of the role and the person specification outlines the qualifications, skills, experience and knowledge required. For both overviews please view the Job Description attachment with the job advert. Person specification Education Honours Degree in a Physical Science MSc in Medical Physics or equivalent subject or equivalent experience Registration with the Health and Care Professions Council (HCPC) Advanced professional training in magnetic resonance physics or equivalent 1st or 2nd class honours degree PhD in a relevant subject Skills Proven competence in understanding and application of MR physics and safety Specialist knowledge and understanding of regulations, recommendations and guidelines Self-motivated/ability for problem solving and decision making Able to work independently providing specialist advice to the Trust and SLA customers Experience Significant experience in application of MR physics in a clinical environment Specialist experience in MR systems, image acquisition and image processing Experience in giving responsible MR safety advice Experience in teaching and training junior staff members and STP trainees Please ensure you check your emails regularly as this is how we will communicate with you throughout the recruitment process. If you are shortlisted you will be contacted by email and text message (if you provide a mobile contact number). Employer certification / accreditation badges You must have appropriate UK professional registration. The postholder will have access to vulnerable people in the course of their normal duties and as such this post is subject to the Rehabilitation of Offenders Act 1974 (Exceptions) Order 1975 (Amendment) (England and Wales) Order 2020 and as such it will be necessary for a submission for Disclosure to be made to the Disclosure and Barring Service to check for any previous criminal convictions.
Main area Physics Grade NHS AfC: Band 7 Contract 12 months (Fixed term (until 29-Aug-2026 Hours Full time - 37.5 hours per week Job ref 282-SB661 Employer The Royal Marsden NHS Foundation Trust Employer type NHS Site The Royal Marsden Sutton Town Sutton Salary £51,883 - £58,544 per annum Salary period Yearly Closing 23/07/:59 Job overview We are looking for an enthusiastic clinical physicist to join the Radiotherapy Physics group at band 7 at the Sutton branch of the Royal Marsden Hospital, on a fixed term appointment until August 2026. Extensions are possible but cannot be guaranteed at this time. An appointment may be made at a lower band for a less qualified candidate. As part of the physics team, you will support all radiotherapy work at a specialist centre. Treatment planning is performed using the RayStation treatment planning system, with most treatment sites planned using a VMAT technique. We have established workflows for adaptive radiotherapy (both online adaptive and plan of the day), 4DCT, and breathhold techniques. Multimodality imaging (CT, PET-CT, MR) is used for planning of several treatment sites. Recent clinical development work has included developing planning and quality control techniques for helical delivery on our new Radixact units. The Radiotherapy Department in Sutton has 5 Elekta linacs, an Elekta Unity MR-Linac, a Cyberknife S7, two Accuray Radixacts and an XStrahl superficial unit. The radiotherapy physics group consists of 40 physicists, dosimetrists and engineers and forms a substantial part of the Royal Marsden/Institute of Cancer Research Joint Department of Physics, through which we have many active research collaborations, most notably on the MR-linac which was the first in the UK to treat patients. Main duties of the job The post holder will provide specialist support to all aspects of the clinical, scientific and technical Radiotherapy Physics Service to Radiotherapy. The post holder has particular clinical and scientific responsibilities for day-to-day essential complex treatment planning and checking and performing Quality Assurance and dosimetry and analysing results. Responsible for ensuring radiographers and trainee clinical scientists are supervised and assisted in their training and to act as their mentor. Supervise and assign junior staff and participate on clinical duties as outlined in the activities of the Radiotherapy Physics Group on a day-to-day basis as indicted by the duty rota. Work closely with the Principal Physicist in all areas. Working for our organisation The Royal Marsden NHS Foundation Trust is a world-leading cancer centre. Our role is to offer our patients the best cancer care available anywhere in the world, and to continue to make a global contribution to finding better ways of diagnosing and treating cancer. We employ over 4,500 staff in a diverse range of careers including nursing, medical, science, radiography, pharmacy, occupational therapy, finance and administrative services. We have two hospitals - one in Chelsea, London, and one in Sutton, Surrey - as well as a Medical Daycare Unit in Kingston Hospital. At The Royal Marsden, we deal with cancer every day, so we understand how valuable life is. When people entrust their lives to us, they have the right to demand the very best. That's why the pursuit of excellence lies at the heart of everything we do. At the heart of the hospital is our dedicated team. We offer a stimulating and dynamic working environment, a wide range of staff benefits, learning and development opportunities and clear career pathways. There are opportunities to work flexibly across a range of areas and specialities and we welcome flexible working requests from point of hire to support employees work life balance. We are looking for employees who aspire to excellence, share our values and can play a crucial role in our on-going achievements. Detailed job description and main responsibilities For further information on this role, please see the attached detailed Job Description and Person Specification: Participate in the commissioning of new radiotherapy treatment equipment, including the preparation and checking of complex beam data for treatment planning systems. Perform and advise on dosimetry measurements in patients. Provide complex advice to clinical staff and support developments in treatment planning. Replan patient treatments where required, following a treatment error or changes in patient shape. Use judgement to analyse and determine the most appropriate compensation method. Calculate the compensation required and subsequent patient dose. Carry out manual dose calculations. Check and approve routine and complex treatment plans, dose calculations and templates produced by other members of staff. Person specification Scientific Grades Good (1st or 2nd class) Honours degree in a relevant subject MSc in radiation Physics (or equivalent) PhD in relevant subject or equivalent specialised scientific knowledge IPEM Diploma or equivalent in Medical Physics or Medical Engineering. Registration Close to achieving or HCPC Registered as a Clinical Scientist Scientific/Technical/Specialist Basic knowledge across the range of working procedures and practices in radiotherapy physics, building on theoretical knowledge and practical experience. Practical experience in clinical radiotherapy treatment planning and in the use of dosimetry equipment in radiotherapy Specialist training on and practical experience with a range of radiotherapy treatment & simulation/scanning equipment, including clinical applications. IT Able to use Excel, Word, etc.to set up documents and spreadsheets, extract information Able to set up and manage the acquisition, structure and networking of information, including image transfer formats Experience in programming (e.g. in one or more of Python, C++, JAVA, R, MATLAB) Communication Able to communicate highly complex information at postgraduate level to other professional groups Able to present scientific papers at national and international conferences and write up scientific material for publication The Royal Marsden values diversity and is committed to the recruitment and retention of underrepresented minority groups. We particularly welcome applications from Black, Asian and minority ethnic candidates, LGBTQ+ candidates and candidates with disabilities. As a Disability Confident Employer, we are working to create a workplace that enables all staff to reach their full potential. We are committed to this because we know that greater diversity and inclusion will lead to an even greater positive impact for the people we serve. Due to the high volumes of applications we receive, we reserve the right to close any adverts before the published closing date once we have received a sufficient number of applications. We advise you to submit your application as early as possible to prevent disappointment. All applicants will be contacted by email to the address supplied on your application. Applicants are advised to check their email accounts regularly and to ensure that email filters are set to allow our emails. Flu Vaccination - What We Expect of our Staff At The Royal Marsden we have an immune compromised patient population who we must protect as much as we can against the flu virus. Each year, seasonal flu affects thousands of people in the UK. Occurring mainly in winter, it is an infectious respiratory disease capable of producing symptoms ranging from those similar to a common cold, through to very severe or even fatal disease. The wellbeing of our staff and patients is of the upmost importance to us, and it is the expectation of The Royal Marsden that all patient-facing staff have an annual flu vaccination, provided free of charge by the Trust. Employer certification / accreditation badges You must have appropriate UK professional registration. This post is subject to the Rehabilitation of Offenders Act 1974 (Exceptions) Order 1975 (Amendment) (England and Wales) Order 2020 and it will be necessary for a submission for Disclosure to be made to the Disclosure and Barring Service.
Jul 15, 2025
Full time
Main area Physics Grade NHS AfC: Band 7 Contract 12 months (Fixed term (until 29-Aug-2026 Hours Full time - 37.5 hours per week Job ref 282-SB661 Employer The Royal Marsden NHS Foundation Trust Employer type NHS Site The Royal Marsden Sutton Town Sutton Salary £51,883 - £58,544 per annum Salary period Yearly Closing 23/07/:59 Job overview We are looking for an enthusiastic clinical physicist to join the Radiotherapy Physics group at band 7 at the Sutton branch of the Royal Marsden Hospital, on a fixed term appointment until August 2026. Extensions are possible but cannot be guaranteed at this time. An appointment may be made at a lower band for a less qualified candidate. As part of the physics team, you will support all radiotherapy work at a specialist centre. Treatment planning is performed using the RayStation treatment planning system, with most treatment sites planned using a VMAT technique. We have established workflows for adaptive radiotherapy (both online adaptive and plan of the day), 4DCT, and breathhold techniques. Multimodality imaging (CT, PET-CT, MR) is used for planning of several treatment sites. Recent clinical development work has included developing planning and quality control techniques for helical delivery on our new Radixact units. The Radiotherapy Department in Sutton has 5 Elekta linacs, an Elekta Unity MR-Linac, a Cyberknife S7, two Accuray Radixacts and an XStrahl superficial unit. The radiotherapy physics group consists of 40 physicists, dosimetrists and engineers and forms a substantial part of the Royal Marsden/Institute of Cancer Research Joint Department of Physics, through which we have many active research collaborations, most notably on the MR-linac which was the first in the UK to treat patients. Main duties of the job The post holder will provide specialist support to all aspects of the clinical, scientific and technical Radiotherapy Physics Service to Radiotherapy. The post holder has particular clinical and scientific responsibilities for day-to-day essential complex treatment planning and checking and performing Quality Assurance and dosimetry and analysing results. Responsible for ensuring radiographers and trainee clinical scientists are supervised and assisted in their training and to act as their mentor. Supervise and assign junior staff and participate on clinical duties as outlined in the activities of the Radiotherapy Physics Group on a day-to-day basis as indicted by the duty rota. Work closely with the Principal Physicist in all areas. Working for our organisation The Royal Marsden NHS Foundation Trust is a world-leading cancer centre. Our role is to offer our patients the best cancer care available anywhere in the world, and to continue to make a global contribution to finding better ways of diagnosing and treating cancer. We employ over 4,500 staff in a diverse range of careers including nursing, medical, science, radiography, pharmacy, occupational therapy, finance and administrative services. We have two hospitals - one in Chelsea, London, and one in Sutton, Surrey - as well as a Medical Daycare Unit in Kingston Hospital. At The Royal Marsden, we deal with cancer every day, so we understand how valuable life is. When people entrust their lives to us, they have the right to demand the very best. That's why the pursuit of excellence lies at the heart of everything we do. At the heart of the hospital is our dedicated team. We offer a stimulating and dynamic working environment, a wide range of staff benefits, learning and development opportunities and clear career pathways. There are opportunities to work flexibly across a range of areas and specialities and we welcome flexible working requests from point of hire to support employees work life balance. We are looking for employees who aspire to excellence, share our values and can play a crucial role in our on-going achievements. Detailed job description and main responsibilities For further information on this role, please see the attached detailed Job Description and Person Specification: Participate in the commissioning of new radiotherapy treatment equipment, including the preparation and checking of complex beam data for treatment planning systems. Perform and advise on dosimetry measurements in patients. Provide complex advice to clinical staff and support developments in treatment planning. Replan patient treatments where required, following a treatment error or changes in patient shape. Use judgement to analyse and determine the most appropriate compensation method. Calculate the compensation required and subsequent patient dose. Carry out manual dose calculations. Check and approve routine and complex treatment plans, dose calculations and templates produced by other members of staff. Person specification Scientific Grades Good (1st or 2nd class) Honours degree in a relevant subject MSc in radiation Physics (or equivalent) PhD in relevant subject or equivalent specialised scientific knowledge IPEM Diploma or equivalent in Medical Physics or Medical Engineering. Registration Close to achieving or HCPC Registered as a Clinical Scientist Scientific/Technical/Specialist Basic knowledge across the range of working procedures and practices in radiotherapy physics, building on theoretical knowledge and practical experience. Practical experience in clinical radiotherapy treatment planning and in the use of dosimetry equipment in radiotherapy Specialist training on and practical experience with a range of radiotherapy treatment & simulation/scanning equipment, including clinical applications. IT Able to use Excel, Word, etc.to set up documents and spreadsheets, extract information Able to set up and manage the acquisition, structure and networking of information, including image transfer formats Experience in programming (e.g. in one or more of Python, C++, JAVA, R, MATLAB) Communication Able to communicate highly complex information at postgraduate level to other professional groups Able to present scientific papers at national and international conferences and write up scientific material for publication The Royal Marsden values diversity and is committed to the recruitment and retention of underrepresented minority groups. We particularly welcome applications from Black, Asian and minority ethnic candidates, LGBTQ+ candidates and candidates with disabilities. As a Disability Confident Employer, we are working to create a workplace that enables all staff to reach their full potential. We are committed to this because we know that greater diversity and inclusion will lead to an even greater positive impact for the people we serve. Due to the high volumes of applications we receive, we reserve the right to close any adverts before the published closing date once we have received a sufficient number of applications. We advise you to submit your application as early as possible to prevent disappointment. All applicants will be contacted by email to the address supplied on your application. Applicants are advised to check their email accounts regularly and to ensure that email filters are set to allow our emails. Flu Vaccination - What We Expect of our Staff At The Royal Marsden we have an immune compromised patient population who we must protect as much as we can against the flu virus. Each year, seasonal flu affects thousands of people in the UK. Occurring mainly in winter, it is an infectious respiratory disease capable of producing symptoms ranging from those similar to a common cold, through to very severe or even fatal disease. The wellbeing of our staff and patients is of the upmost importance to us, and it is the expectation of The Royal Marsden that all patient-facing staff have an annual flu vaccination, provided free of charge by the Trust. Employer certification / accreditation badges You must have appropriate UK professional registration. This post is subject to the Rehabilitation of Offenders Act 1974 (Exceptions) Order 1975 (Amendment) (England and Wales) Order 2020 and it will be necessary for a submission for Disclosure to be made to the Disclosure and Barring Service.
CK Group are recruiting for a proactive Principal Scientist, with a strong background in cancer biology and tumour microenvironment, to join a growing biotechnology company, on a permanent basis, to be based in Oxford. This is a great opportunity for a highly motivated scientist, with a commitment to research on anti-cancer therapies to take responsibility in a fast-paced environment, working within an interdisciplinary team to develop new cancer treatments. The Role: Contributing to strategic R&D goals you will be designing, managing, and performing oncolytic immunotherapy studies to support candidate development and inform clinical strategy. The successful will focus on the actions and influence on the tumour microenvironment, and application in new tumour indications. Your Responsibilities: Responsible for study plan design and approval, as well as overseeing data collection, analysis, reporting and for the final conclusions from the study report including sign off. Design and execution of R&D projects. Act as independent scientist reviewer and sign off lab books, verifying the calculations, and approving SOPs. Act as mentor and supervisor. Contributing to presentations, reports and regulatory filings. Your Background: PhD degree or equivalent in a relevant scientific discipline with strong industry expertise in cancer biology and scientific acumen in tumour microenvironment. Significant level of hands on experience in performing in-vivo experiments in oncology models for drug discovery (preferably in humanised immune mouse models). Experience performing i.t. / i.v / i.p injections. Good knowledge of Mode of action, Tumour Micro-environment and spatial transcriptomics/RNA scope. Technical experience on qPCR, RNA/DNA extractions, ELISA and cell-based assays. Active animal licence from the Home Office (DESIRABLE). Experience of in vivo imaging (e.g. bioluminescence), IHC / flow cytometry/ multiplex immunofluorescence. Skilled in bioinformatic analysis. Benefits : Bonus. Pension. Private Medical Insurance. Flexible working hours. Apply: It is essential that applicants hold entitlement to work in the UK. Please quote job reference in all correspondence. If this position isn't suitable but you are looking for a new role, or if you are interested in seeing what opportunities are out there, head over to our LinkedIn page (cka-group) and follow us to see our latest jobs and company news.
Mar 06, 2025
Full time
CK Group are recruiting for a proactive Principal Scientist, with a strong background in cancer biology and tumour microenvironment, to join a growing biotechnology company, on a permanent basis, to be based in Oxford. This is a great opportunity for a highly motivated scientist, with a commitment to research on anti-cancer therapies to take responsibility in a fast-paced environment, working within an interdisciplinary team to develop new cancer treatments. The Role: Contributing to strategic R&D goals you will be designing, managing, and performing oncolytic immunotherapy studies to support candidate development and inform clinical strategy. The successful will focus on the actions and influence on the tumour microenvironment, and application in new tumour indications. Your Responsibilities: Responsible for study plan design and approval, as well as overseeing data collection, analysis, reporting and for the final conclusions from the study report including sign off. Design and execution of R&D projects. Act as independent scientist reviewer and sign off lab books, verifying the calculations, and approving SOPs. Act as mentor and supervisor. Contributing to presentations, reports and regulatory filings. Your Background: PhD degree or equivalent in a relevant scientific discipline with strong industry expertise in cancer biology and scientific acumen in tumour microenvironment. Significant level of hands on experience in performing in-vivo experiments in oncology models for drug discovery (preferably in humanised immune mouse models). Experience performing i.t. / i.v / i.p injections. Good knowledge of Mode of action, Tumour Micro-environment and spatial transcriptomics/RNA scope. Technical experience on qPCR, RNA/DNA extractions, ELISA and cell-based assays. Active animal licence from the Home Office (DESIRABLE). Experience of in vivo imaging (e.g. bioluminescence), IHC / flow cytometry/ multiplex immunofluorescence. Skilled in bioinformatic analysis. Benefits : Bonus. Pension. Private Medical Insurance. Flexible working hours. Apply: It is essential that applicants hold entitlement to work in the UK. Please quote job reference in all correspondence. If this position isn't suitable but you are looking for a new role, or if you are interested in seeing what opportunities are out there, head over to our LinkedIn page (cka-group) and follow us to see our latest jobs and company news.
North Middlesex University Hospital NHS Trust We have an exciting opportunity to join our friendly, forward-thinking department in North Middlesex Hospital site - North London as a Band 7 Radiotherapy Physicist. The department provides a comprehensive physics service to support the delivery of radiotherapy treatment at North Middlesex Hospital . This includes all treatment planning, machine quality assurance, and the provision of molecular radiotherapy. The department consists of 9 clinical scientists, including this post, 6 dosimetrists, and 4 engineering and technical staff. The Radiotherapy department has a mix of Varian TrueBeam and Halcyon Linacs and an XStrahl superficial unit. One of our TrueBeams is to be replaced later this year, so there will be lots of scope to get involved in commissioning of cutting-edge equipment. Varian Eclipse is used for all treatment planning activities, and we have ongoing projects to implement and expand knowledge-based planning, AI auto-contouring, scripting, and automation, and lots more besides. Flexible working is supported across the Trust and the team continues to enjoy a hybrid pattern of on-site and working from home. This would suit candidates who have recently completed their STP training and gained HCPC registration, although those due to complete soon are also encouraged to apply. Main duties of the job The post holder will participate in the general Radiotherapy Physics service provision to the North Middlesex Hospital site . The post holder may be required to specialise in one or more sections within the Radiotherapy Physics service. The physicist's role is to ensure the safe delivery of the Radiotherapy Physics service assisting the Head of the service as well as the designated Medical Physics Experts in their various areas of responsibility. The post holder will be responsible to the Deputy Head of Radiotherapy Physics and to the Principal Physicists when working in their specific areas. The post holder will also be expected to work closely with Radiotherapy Radiographers, Clinical Oncologists, and Specialist Radiotherapy Registrars. Job responsibilities 1. Clinical Scientific Produce routine and complex treatment plans for external beam radiotherapy. Use computerised planning systems to design and customise treatment plans. Take responsibility for the accurate production of individualised treatment plans and associated dosimetry calculations. Advise clinical staff on the effects of various treatment plan options on patient dose distributions. Discuss and agree approaches with clinical staff to create optimum treatment plans and advise on aspects of the treatment and patient set-up, as required. Check and approve routine and complex treatment plans, dose calculations, and templates produced by other members of staff. 2. General Provide support to Physics computing in Radiotherapy. Write software to the requirements of the department and adapt existing software packages as required. Monitor and resolve problems on computing systems in Radiotherapy and Radiotherapy Physics. Participate in acceptance testing and commissioning of new equipment as appropriate. Person Specification Education and Professional Qualifications (1st or 2nd class) Honours degree in a physical science or equivalent. IPEM training exit certificate or equivalent experience Registration as Clinical Scientist with HCPC or achievement within 12 months of appointment Experience Experience in the clinical environment with patients and clinical staff Good knowledge of radiotherapy physics, radiotherapy techniques, and clinical applications Knowledge of appropriate legislation Knowledge of relevant anatomy, physiology, and pathology Skills and aptitudes Ability to communicate technical material to colleagues and other professionals Able to deal with complex and unpredictable situations Ability to organise own workload Exhibits independent approach to problem solving Exhibits a keen interest in research and development Personal qualities and attributes Ability to work as part of a team Personal presentation acceptable to clinical staff and patients. Ability to show a sympathetic and caring attitude to patients of diverse cultures Disclosure and Barring Service Check This post is subject to the Rehabilitation of Offenders Act (Exceptions Order) 1975 and as such it will be necessary for a submission for Disclosure to be made to the Disclosure and Barring Service (formerly known as CRB) to check for any previous criminal convictions. Salary: £51,883 to £58,544 per annum inclusive of HCAs
Feb 20, 2025
Full time
North Middlesex University Hospital NHS Trust We have an exciting opportunity to join our friendly, forward-thinking department in North Middlesex Hospital site - North London as a Band 7 Radiotherapy Physicist. The department provides a comprehensive physics service to support the delivery of radiotherapy treatment at North Middlesex Hospital . This includes all treatment planning, machine quality assurance, and the provision of molecular radiotherapy. The department consists of 9 clinical scientists, including this post, 6 dosimetrists, and 4 engineering and technical staff. The Radiotherapy department has a mix of Varian TrueBeam and Halcyon Linacs and an XStrahl superficial unit. One of our TrueBeams is to be replaced later this year, so there will be lots of scope to get involved in commissioning of cutting-edge equipment. Varian Eclipse is used for all treatment planning activities, and we have ongoing projects to implement and expand knowledge-based planning, AI auto-contouring, scripting, and automation, and lots more besides. Flexible working is supported across the Trust and the team continues to enjoy a hybrid pattern of on-site and working from home. This would suit candidates who have recently completed their STP training and gained HCPC registration, although those due to complete soon are also encouraged to apply. Main duties of the job The post holder will participate in the general Radiotherapy Physics service provision to the North Middlesex Hospital site . The post holder may be required to specialise in one or more sections within the Radiotherapy Physics service. The physicist's role is to ensure the safe delivery of the Radiotherapy Physics service assisting the Head of the service as well as the designated Medical Physics Experts in their various areas of responsibility. The post holder will be responsible to the Deputy Head of Radiotherapy Physics and to the Principal Physicists when working in their specific areas. The post holder will also be expected to work closely with Radiotherapy Radiographers, Clinical Oncologists, and Specialist Radiotherapy Registrars. Job responsibilities 1. Clinical Scientific Produce routine and complex treatment plans for external beam radiotherapy. Use computerised planning systems to design and customise treatment plans. Take responsibility for the accurate production of individualised treatment plans and associated dosimetry calculations. Advise clinical staff on the effects of various treatment plan options on patient dose distributions. Discuss and agree approaches with clinical staff to create optimum treatment plans and advise on aspects of the treatment and patient set-up, as required. Check and approve routine and complex treatment plans, dose calculations, and templates produced by other members of staff. 2. General Provide support to Physics computing in Radiotherapy. Write software to the requirements of the department and adapt existing software packages as required. Monitor and resolve problems on computing systems in Radiotherapy and Radiotherapy Physics. Participate in acceptance testing and commissioning of new equipment as appropriate. Person Specification Education and Professional Qualifications (1st or 2nd class) Honours degree in a physical science or equivalent. IPEM training exit certificate or equivalent experience Registration as Clinical Scientist with HCPC or achievement within 12 months of appointment Experience Experience in the clinical environment with patients and clinical staff Good knowledge of radiotherapy physics, radiotherapy techniques, and clinical applications Knowledge of appropriate legislation Knowledge of relevant anatomy, physiology, and pathology Skills and aptitudes Ability to communicate technical material to colleagues and other professionals Able to deal with complex and unpredictable situations Ability to organise own workload Exhibits independent approach to problem solving Exhibits a keen interest in research and development Personal qualities and attributes Ability to work as part of a team Personal presentation acceptable to clinical staff and patients. Ability to show a sympathetic and caring attitude to patients of diverse cultures Disclosure and Barring Service Check This post is subject to the Rehabilitation of Offenders Act (Exceptions Order) 1975 and as such it will be necessary for a submission for Disclosure to be made to the Disclosure and Barring Service (formerly known as CRB) to check for any previous criminal convictions. Salary: £51,883 to £58,544 per annum inclusive of HCAs
University Hospitals of Leicester NHS Trust Maternity Leave Cover 1 year Fixed Term Contract We are looking for an enthusiastic and dynamic Perfusion Scientist who works well under pressure and is looking to work in a busy Cardiac centre undertaking a full range of Perfusion techniques. The post is to cover maternity leave within the team and would be an opportunity to become an important member of a team of 12 Perfusionists providing the most up-to-date techniques in Perfusion. This post would be an excellent opportunity for a qualified Perfusionist to come to Glenfield for 1 year to learn about Paediatric Perfusion techniques and Adult and Paediatric ECMO as well as working with the team on our Adult Cardiopulmonary patients. We are an experienced centre with a lot to give. The department currently undertakes 1000 adult and 350 neonatal/paediatric cases, along with 100 neonatal, paediatric and adult ECMO's and IABP support. You must be accredited by the Society of Perfusionists of Great Britain & Ireland and registered with the College of Clinical Perfusionists of Great Britain & Ireland, and it would be an advantage to be conversant with all relevant perfusion techniques. However, training will be given in Paediatrics and ECMO if only Adult trained and vice versa. Participation in the department on-call rota is essential. The department offers a 37.5 hour, 4-day working week in Adults and a 3-day working week in Paediatrics. We encourage personal development and research. Main duties of the job Set up, prime and run cardiopulmonary bypass equipment for cardiac surgery procedures, according to the perfusion procedures and protocols and play a full role in the routine cardiac surgery programme. Facilitate the provision of a transport ECMO service along with the accompanied maintenance, troubleshooting and staff training associated with this role. Ensure the provision of extracorporeal life support systems, ventricular assist devices, haemoconcentration, cell salvage and Intra Aortic Balloon Counterpulsation. Ensure the continued maintenance and servicing of clinical equipment pertinent to cardiac surgery. Take part in the provision of training for perfusion students and other staff groups when required. Take part in an on-call rota for emergency service provision. Procure disposable/non-disposable equipment for the department. Be active in the ongoing research programme in the Perfusion Department. Provide clinical and scientific advice, and interpretation of results to clinicians throughout the Trust and to external agencies. Draw on knowledge of a range of theories to inform practice. Assist in developing strategies for the management and delivery of care for the patient group. About us Our new strategy, developed with the support and feedback of colleagues, patients, and partners, is our compass for the next seven years (). We have four primary goals: High-quality care for all, Being a great place to work, Partnerships for impact, and Research and education excellence. And we will embed health equality in all we do - taking active steps to reduce the avoidable differences in healthcare that some people face, working in partnership with communities. Our strategy is underpinned by new values and we will work to ensure they are an everyday reality for all: We are compassionate, We are proud, We are inclusive, and We are one team. This is an exciting moment as we look to the future with clarity on what we already do well and where we need to focus our energies to make an even bigger difference for the people we serve. Job responsibilities Staff The Perfusion team consists of 9.81 fully qualified team members who are accountable to the Principal Perfusionist who is the direct line Manager. Appraisal is undertaken every year and through this performance, attendance, and training development will be reviewed. The appraisal is undertaken by the Principal Perfusionist. Policy To contribute to multi-disciplinary team building and policy development. To adhere to team plans and policies. Communications Utilise a variety of strategies to communicate highly complex, sensitive information about the service area to staff, Perfusion Manager, Service Manager. Develop and maintain relationships and effective and proactive communication mechanisms with staff, their representatives and staff organisations so that the Directorate is able to secure participation in and favourable reactions to its aims and objectives. Contribute to clinical teams, both multi-disciplinary and uni-disciplinary, by discussing own and others input around patient need ensuring a well-coordinated care plan. Communicate complex condition-related information from assessment to members of the multi-disciplinary team / other professions. Work closely with colleagues in the multi-disciplinary team agreeing decision making relevant to patient management. Advise other colleagues on a range of clinical therapy issues and facilitate their own problem-solving skills. Be a motivated member of the team and engage in all departmental activities. Demonstrate excellent negotiation skills in the management of conflict across a range of situations. Deal with complaints sensitively, avoiding escalation where possible. Form productive relationships with others who may be under stress. Employ excellent communication skills in emotive, stressful and potentially antagonistic situations. Employ excellent presentation skills to promote multidisciplinary and inter-departmental liaison, collaborative practice and understanding of the specialist clinical area to a broad range of audiences, including other professionals and users. Person Specification Qualifications BSc in Perfusion Science/ PgDip in Perfusion Science / MSc in Perfusion Science / Society of Perfusionists Accreditation Examination. LCCP/Overseas applicants require a primary perfusion qualification plus evidence of 75 unsupervised clinical cases. Experience Preferably 3 years post-qualification. Paediatric Experience although training will be given. Knowledge A good knowledge of Cardiac and Perfusion Techniques. A knowledge of ECMO procedures as well as Paediatric procedures. Disclosure and Barring Service Check This post is subject to the Rehabilitation of Offenders Act (Exceptions Order) 1975 and as such it will be necessary for a submission for Disclosure to be made to the Disclosure and Barring Service (formerly known as CRB) to check for any previous criminal convictions. University Hospitals of Leicester NHS Trust £53,755 to £60,504 a year per annum / pro rata for part-time hours.
Feb 18, 2025
Full time
University Hospitals of Leicester NHS Trust Maternity Leave Cover 1 year Fixed Term Contract We are looking for an enthusiastic and dynamic Perfusion Scientist who works well under pressure and is looking to work in a busy Cardiac centre undertaking a full range of Perfusion techniques. The post is to cover maternity leave within the team and would be an opportunity to become an important member of a team of 12 Perfusionists providing the most up-to-date techniques in Perfusion. This post would be an excellent opportunity for a qualified Perfusionist to come to Glenfield for 1 year to learn about Paediatric Perfusion techniques and Adult and Paediatric ECMO as well as working with the team on our Adult Cardiopulmonary patients. We are an experienced centre with a lot to give. The department currently undertakes 1000 adult and 350 neonatal/paediatric cases, along with 100 neonatal, paediatric and adult ECMO's and IABP support. You must be accredited by the Society of Perfusionists of Great Britain & Ireland and registered with the College of Clinical Perfusionists of Great Britain & Ireland, and it would be an advantage to be conversant with all relevant perfusion techniques. However, training will be given in Paediatrics and ECMO if only Adult trained and vice versa. Participation in the department on-call rota is essential. The department offers a 37.5 hour, 4-day working week in Adults and a 3-day working week in Paediatrics. We encourage personal development and research. Main duties of the job Set up, prime and run cardiopulmonary bypass equipment for cardiac surgery procedures, according to the perfusion procedures and protocols and play a full role in the routine cardiac surgery programme. Facilitate the provision of a transport ECMO service along with the accompanied maintenance, troubleshooting and staff training associated with this role. Ensure the provision of extracorporeal life support systems, ventricular assist devices, haemoconcentration, cell salvage and Intra Aortic Balloon Counterpulsation. Ensure the continued maintenance and servicing of clinical equipment pertinent to cardiac surgery. Take part in the provision of training for perfusion students and other staff groups when required. Take part in an on-call rota for emergency service provision. Procure disposable/non-disposable equipment for the department. Be active in the ongoing research programme in the Perfusion Department. Provide clinical and scientific advice, and interpretation of results to clinicians throughout the Trust and to external agencies. Draw on knowledge of a range of theories to inform practice. Assist in developing strategies for the management and delivery of care for the patient group. About us Our new strategy, developed with the support and feedback of colleagues, patients, and partners, is our compass for the next seven years (). We have four primary goals: High-quality care for all, Being a great place to work, Partnerships for impact, and Research and education excellence. And we will embed health equality in all we do - taking active steps to reduce the avoidable differences in healthcare that some people face, working in partnership with communities. Our strategy is underpinned by new values and we will work to ensure they are an everyday reality for all: We are compassionate, We are proud, We are inclusive, and We are one team. This is an exciting moment as we look to the future with clarity on what we already do well and where we need to focus our energies to make an even bigger difference for the people we serve. Job responsibilities Staff The Perfusion team consists of 9.81 fully qualified team members who are accountable to the Principal Perfusionist who is the direct line Manager. Appraisal is undertaken every year and through this performance, attendance, and training development will be reviewed. The appraisal is undertaken by the Principal Perfusionist. Policy To contribute to multi-disciplinary team building and policy development. To adhere to team plans and policies. Communications Utilise a variety of strategies to communicate highly complex, sensitive information about the service area to staff, Perfusion Manager, Service Manager. Develop and maintain relationships and effective and proactive communication mechanisms with staff, their representatives and staff organisations so that the Directorate is able to secure participation in and favourable reactions to its aims and objectives. Contribute to clinical teams, both multi-disciplinary and uni-disciplinary, by discussing own and others input around patient need ensuring a well-coordinated care plan. Communicate complex condition-related information from assessment to members of the multi-disciplinary team / other professions. Work closely with colleagues in the multi-disciplinary team agreeing decision making relevant to patient management. Advise other colleagues on a range of clinical therapy issues and facilitate their own problem-solving skills. Be a motivated member of the team and engage in all departmental activities. Demonstrate excellent negotiation skills in the management of conflict across a range of situations. Deal with complaints sensitively, avoiding escalation where possible. Form productive relationships with others who may be under stress. Employ excellent communication skills in emotive, stressful and potentially antagonistic situations. Employ excellent presentation skills to promote multidisciplinary and inter-departmental liaison, collaborative practice and understanding of the specialist clinical area to a broad range of audiences, including other professionals and users. Person Specification Qualifications BSc in Perfusion Science/ PgDip in Perfusion Science / MSc in Perfusion Science / Society of Perfusionists Accreditation Examination. LCCP/Overseas applicants require a primary perfusion qualification plus evidence of 75 unsupervised clinical cases. Experience Preferably 3 years post-qualification. Paediatric Experience although training will be given. Knowledge A good knowledge of Cardiac and Perfusion Techniques. A knowledge of ECMO procedures as well as Paediatric procedures. Disclosure and Barring Service Check This post is subject to the Rehabilitation of Offenders Act (Exceptions Order) 1975 and as such it will be necessary for a submission for Disclosure to be made to the Disclosure and Barring Service (formerly known as CRB) to check for any previous criminal convictions. University Hospitals of Leicester NHS Trust £53,755 to £60,504 a year per annum / pro rata for part-time hours.
Post-doctoral Scientist in Liver-Brain Axis Understanding the mechanisms underlying the detrimental effects of MASLD on the brain Job Title: Post-doctoral Scientist Group: Liver-Brain Axis Reporting to: Dr Anna Hadjihambi (Principal Investigator) Duration: 3 years Salary: £44,501 per annum Annual leave: 27 days per annum plus bank holidays Hours: Full time, 36.5 hours per week Starting date: June 2025 (flexible) The Liver-Brain Axis Group, led by Dr Anna Hadjihambi at The Roger Williams Institute of Liver Studies, is seeking a highly motivated Post-Doctoral scientist with a strong background in Neuroscience and/or Physiology. This position offers an exciting opportunity to work on a translational interdisciplinary research programme funded by the UKRI Future Leaders Fellowship. The aim of this research is to advance our understanding of the abnormal physiological processes associated with metabolic dysfunction associated steatotic liver disease (MASLD), focusing on the brain and cerebrovascular system. This project will investigate the hypothesis that reduced metabolic supply is responsible for the cognitive impairment and decreased quality of life reported in patients with MASLD and develops as a result of disease-induced autonomic dysfunction. We aim to study whether MASLD induced changes in the brain's blood vessels can be reversed by resolving liver disease, or if the cerebrovascular damage is irreversible, thus making the brain more fragile during ageing. This role provides a unique opportunity to engage in basic and translational science and combine state-of-the-art experimental animal in vivo methods and molecular biology techniques, to address clinically compelling questions. The Roger Williams Institute of Liver Studies is a unique clinical academic partnership between the Foundation for Liver Research, King's College London and King's College Hospital that encompasses a multi-disciplinary team focused on liver research and the improvement of outcomes for patients with liver diseases. This role would be employed by the Foundation for Liver Research, registered charity no. . Role and remit The successful candidate will be working closely with faculty and with interdisciplinary national and international collaborators at the crossroads of physiology, hepatology, neuroscience, and data science. The focus of this role will be on characterising alterations in the autonomic nervous system induced by MASLD. Areas of interest for this position include, but are not limited to, in vivo electrophysiology of different branches of the vagus nerve, confocal imaging, biotelemetry implantations and associated data analysis and interpretation. All in vivo experiments will be performed at our collaborator's laboratory in University College London and will require equipment sharing. Key responsibilities Plan and execute experiments both independently and in collaboration with other team members, the PI, and collaborators Data collection and interpretation to generate new ideas to drive the project forward Liaise with collaborators on relevant work packages Write and submit conference abstracts and manuscripts to communicate and present the research findings. Contribute to mentorship and supervision of junior research team members (including students) Organise and lead public engagement events alongside team and institute members Prepare and submit relevant records and study forms in regard to animal research to the Biological Support Unit (BSU) Experience, skills and knowledge Essential • Strong background in Neuroscience and/or Physiology (or relevant disciplines) • Experience with in vivo experiments in mice preferably: • Micro injections • Cannulation of vessels (acute and/or chronic) • In vivo electrophysiology • Experience with managing multiple experiments of moderate scale • Experience with data analysis, statistics, and presentation • Evidence of working in a team (e.g. collaborative projects) Highly desirable • Personal animal license • Knowledge of the autonomic nervous system • Experience with confocal imaging and image analysis • Knowledge of large dataset analysis, interpretation and visualisation • Experience with manuscript preparation (depending on career stage) Advantages of working with us 27 days annual leave plus bank holidays Generous pension scheme with a minimum employer contribution of 8% which increases based on a higher rate of personal contribution Flexible, family-friendly working conditions Our core values: We prioritise the wellbeing of our scientists through sustainable working practices and balance. Commitment to career development: We offer various training and development opportunities, as well as support for future fellowship applications. Welcoming Environment: We celebrate individuality and maintain a friendly atmosphere where everyone feels welcome. Mentorship: We value mentorship and camaraderie, promoting a supportive atmosphere where all group members aid each other in achieving our goals. Equality, Diversity, and Inclusion: Everyone in the team is treated equally. Open Communication: We value direct and honest communication. Intellectual Rigor and Integrity: We are committed to conducting rigorous, ethical, and transparent research. Lab Safety Commitment We look forward to receiving your: • narrative CV • 1-page covering letter explaining your background and suitability • names and contact details of two referees by email to Jenny Dines HR Manager, Foundation for Liver Research. We are happy to accommodate any reasonable adjustments that candidates may need during the recruitment process. Please name documents you send as follows: Quote Job Ref: RS68 For further information about the Roger Williams Institute of Liver Studies please visit our website. Questions regarding the position should be directed to Dr Anna Hadjihambi by email
Feb 15, 2025
Full time
Post-doctoral Scientist in Liver-Brain Axis Understanding the mechanisms underlying the detrimental effects of MASLD on the brain Job Title: Post-doctoral Scientist Group: Liver-Brain Axis Reporting to: Dr Anna Hadjihambi (Principal Investigator) Duration: 3 years Salary: £44,501 per annum Annual leave: 27 days per annum plus bank holidays Hours: Full time, 36.5 hours per week Starting date: June 2025 (flexible) The Liver-Brain Axis Group, led by Dr Anna Hadjihambi at The Roger Williams Institute of Liver Studies, is seeking a highly motivated Post-Doctoral scientist with a strong background in Neuroscience and/or Physiology. This position offers an exciting opportunity to work on a translational interdisciplinary research programme funded by the UKRI Future Leaders Fellowship. The aim of this research is to advance our understanding of the abnormal physiological processes associated with metabolic dysfunction associated steatotic liver disease (MASLD), focusing on the brain and cerebrovascular system. This project will investigate the hypothesis that reduced metabolic supply is responsible for the cognitive impairment and decreased quality of life reported in patients with MASLD and develops as a result of disease-induced autonomic dysfunction. We aim to study whether MASLD induced changes in the brain's blood vessels can be reversed by resolving liver disease, or if the cerebrovascular damage is irreversible, thus making the brain more fragile during ageing. This role provides a unique opportunity to engage in basic and translational science and combine state-of-the-art experimental animal in vivo methods and molecular biology techniques, to address clinically compelling questions. The Roger Williams Institute of Liver Studies is a unique clinical academic partnership between the Foundation for Liver Research, King's College London and King's College Hospital that encompasses a multi-disciplinary team focused on liver research and the improvement of outcomes for patients with liver diseases. This role would be employed by the Foundation for Liver Research, registered charity no. . Role and remit The successful candidate will be working closely with faculty and with interdisciplinary national and international collaborators at the crossroads of physiology, hepatology, neuroscience, and data science. The focus of this role will be on characterising alterations in the autonomic nervous system induced by MASLD. Areas of interest for this position include, but are not limited to, in vivo electrophysiology of different branches of the vagus nerve, confocal imaging, biotelemetry implantations and associated data analysis and interpretation. All in vivo experiments will be performed at our collaborator's laboratory in University College London and will require equipment sharing. Key responsibilities Plan and execute experiments both independently and in collaboration with other team members, the PI, and collaborators Data collection and interpretation to generate new ideas to drive the project forward Liaise with collaborators on relevant work packages Write and submit conference abstracts and manuscripts to communicate and present the research findings. Contribute to mentorship and supervision of junior research team members (including students) Organise and lead public engagement events alongside team and institute members Prepare and submit relevant records and study forms in regard to animal research to the Biological Support Unit (BSU) Experience, skills and knowledge Essential • Strong background in Neuroscience and/or Physiology (or relevant disciplines) • Experience with in vivo experiments in mice preferably: • Micro injections • Cannulation of vessels (acute and/or chronic) • In vivo electrophysiology • Experience with managing multiple experiments of moderate scale • Experience with data analysis, statistics, and presentation • Evidence of working in a team (e.g. collaborative projects) Highly desirable • Personal animal license • Knowledge of the autonomic nervous system • Experience with confocal imaging and image analysis • Knowledge of large dataset analysis, interpretation and visualisation • Experience with manuscript preparation (depending on career stage) Advantages of working with us 27 days annual leave plus bank holidays Generous pension scheme with a minimum employer contribution of 8% which increases based on a higher rate of personal contribution Flexible, family-friendly working conditions Our core values: We prioritise the wellbeing of our scientists through sustainable working practices and balance. Commitment to career development: We offer various training and development opportunities, as well as support for future fellowship applications. Welcoming Environment: We celebrate individuality and maintain a friendly atmosphere where everyone feels welcome. Mentorship: We value mentorship and camaraderie, promoting a supportive atmosphere where all group members aid each other in achieving our goals. Equality, Diversity, and Inclusion: Everyone in the team is treated equally. Open Communication: We value direct and honest communication. Intellectual Rigor and Integrity: We are committed to conducting rigorous, ethical, and transparent research. Lab Safety Commitment We look forward to receiving your: • narrative CV • 1-page covering letter explaining your background and suitability • names and contact details of two referees by email to Jenny Dines HR Manager, Foundation for Liver Research. We are happy to accommodate any reasonable adjustments that candidates may need during the recruitment process. Please name documents you send as follows: Quote Job Ref: RS68 For further information about the Roger Williams Institute of Liver Studies please visit our website. Questions regarding the position should be directed to Dr Anna Hadjihambi by email
Overview About Certara Certara is a growing company that provides a dynamic and exciting place to work. Our purpose is to assist in accelerating the development of meaningful medicines that make an impact on our society and the people that need them most. Innovation and creativity are highly valued, and everyone is given the opportunity for training and continuous development. Our portfolio spans the discovery, preclinical, clinical and post-marketing phases of drug development, working with 1,200 commercial companies, 250 academic institutions, and numerous regulatory agencies. The Certara Quantitative Systems Pharmacology (QSP) group is a global organization focused on the impactful application of QSP and mechanistic PKPD modeling and simulation in drug discovery and development. We are leading several first-of-its-kind QSP Consortia with more than 10 global pharmaceutical companies and have a rapidly expanding consultancy portfolio. Our QSP scientists work in close collaboration with other Certara staff and clients to generate and use state-of-the-art mechanistic models for decision making in pharmaceutical R&D. The models are designed in close dialogue with clients and developed with a view to creating user-friendly tools that will inform drug development programs from discovery to regulatory filing. We have unique capability to seamlessly integrate bespoke QSP models into the Simcyp physiologically based pharmacokinetic (PBPK) platform. Besides our well-established leadership in applied QSP approaches in Immunology and Immuno-Oncology, we are now also the leading provider of QSP approaches in neuro-degenerative diseases through Certara's recent acquisition of the In Silico Biosciences modelling platform. We are seeking highly motivated and talented QSP modelling experts at all levels, who share our passion for using quantitative approaches to understand and impact complex drug discovery and development questions. Positions are available at various levels of experience across our global locations and for flexible, home-based roles. Responsibilities Technical Postdoctoral experience in systems modelling for drug discovery/ development teams. PhD (or equivalent) in life sciences, engineering, computer sciences, mathematics physics or equivalent. Good understanding of PKPD, pharmacology and biology and its application in drug discovery and development. Very familiar and outstanding hands-on expertise with Matlab, Neuron or other similar modelling software. Strong publication record (commensurate with level of experience). Team working Excellent interpersonal skills. Skilled and experienced at facilitating a multi-disciplinary team to work together on a complex project. Ability to communicate with all stakeholders clearly and efficiently. Organised and with track record of delivering quality results on time. Personal Ability to work virtually with project teams across different locations and time zones. Leads by example. Self-reliant. Other skills Highly computer literate and familiar with modern IT and communications technology. Good presentation skills. Combines scientific excellence with ability to make impact in drug discovery and development programs. Ability to manage multiple client project timelines and deliverables simultaneously. Role (depending on experience) Overall responsibility for project delivery of quality QSP solutions on time. Provide hands-on technical support for model building when required. Work with clients to ensure they receive the expected added value. Work with the consortium/ consulting teams to ensure optimal deployment of resources. Work with Certara QSP line management to deliver optimum solutions. Provide general expert technical input across Certara QSP portfolio. Mentor other Certara QSP staff. Qualifications Postdoctoral experience in systems modelling for drug discovery/ development teams. PhD (or equivalent) in life sciences, engineering, computer sciences, mathematics physics or equivalent. Good understanding of PKPD, pharmacology and biology and its application in drug discovery and development. Very familiar and outstanding hands-on expertise with Matlab, Neuron or other similar modelling software. Strong publication record (commensurate with level of experience). Certara bases all employment-related decision on merit, taking into consideration qualifications, skills, achievement, and performance. We treat all applicants and employees without regard to personal characteristics such as race, color, ethnicity, religion, sex, sexual orientation, age, nationality, marital status, pregnancy, physical or mental condition, genetic information, military service, or other characteristic protected by law.
Feb 14, 2025
Full time
Overview About Certara Certara is a growing company that provides a dynamic and exciting place to work. Our purpose is to assist in accelerating the development of meaningful medicines that make an impact on our society and the people that need them most. Innovation and creativity are highly valued, and everyone is given the opportunity for training and continuous development. Our portfolio spans the discovery, preclinical, clinical and post-marketing phases of drug development, working with 1,200 commercial companies, 250 academic institutions, and numerous regulatory agencies. The Certara Quantitative Systems Pharmacology (QSP) group is a global organization focused on the impactful application of QSP and mechanistic PKPD modeling and simulation in drug discovery and development. We are leading several first-of-its-kind QSP Consortia with more than 10 global pharmaceutical companies and have a rapidly expanding consultancy portfolio. Our QSP scientists work in close collaboration with other Certara staff and clients to generate and use state-of-the-art mechanistic models for decision making in pharmaceutical R&D. The models are designed in close dialogue with clients and developed with a view to creating user-friendly tools that will inform drug development programs from discovery to regulatory filing. We have unique capability to seamlessly integrate bespoke QSP models into the Simcyp physiologically based pharmacokinetic (PBPK) platform. Besides our well-established leadership in applied QSP approaches in Immunology and Immuno-Oncology, we are now also the leading provider of QSP approaches in neuro-degenerative diseases through Certara's recent acquisition of the In Silico Biosciences modelling platform. We are seeking highly motivated and talented QSP modelling experts at all levels, who share our passion for using quantitative approaches to understand and impact complex drug discovery and development questions. Positions are available at various levels of experience across our global locations and for flexible, home-based roles. Responsibilities Technical Postdoctoral experience in systems modelling for drug discovery/ development teams. PhD (or equivalent) in life sciences, engineering, computer sciences, mathematics physics or equivalent. Good understanding of PKPD, pharmacology and biology and its application in drug discovery and development. Very familiar and outstanding hands-on expertise with Matlab, Neuron or other similar modelling software. Strong publication record (commensurate with level of experience). Team working Excellent interpersonal skills. Skilled and experienced at facilitating a multi-disciplinary team to work together on a complex project. Ability to communicate with all stakeholders clearly and efficiently. Organised and with track record of delivering quality results on time. Personal Ability to work virtually with project teams across different locations and time zones. Leads by example. Self-reliant. Other skills Highly computer literate and familiar with modern IT and communications technology. Good presentation skills. Combines scientific excellence with ability to make impact in drug discovery and development programs. Ability to manage multiple client project timelines and deliverables simultaneously. Role (depending on experience) Overall responsibility for project delivery of quality QSP solutions on time. Provide hands-on technical support for model building when required. Work with clients to ensure they receive the expected added value. Work with the consortium/ consulting teams to ensure optimal deployment of resources. Work with Certara QSP line management to deliver optimum solutions. Provide general expert technical input across Certara QSP portfolio. Mentor other Certara QSP staff. Qualifications Postdoctoral experience in systems modelling for drug discovery/ development teams. PhD (or equivalent) in life sciences, engineering, computer sciences, mathematics physics or equivalent. Good understanding of PKPD, pharmacology and biology and its application in drug discovery and development. Very familiar and outstanding hands-on expertise with Matlab, Neuron or other similar modelling software. Strong publication record (commensurate with level of experience). Certara bases all employment-related decision on merit, taking into consideration qualifications, skills, achievement, and performance. We treat all applicants and employees without regard to personal characteristics such as race, color, ethnicity, religion, sex, sexual orientation, age, nationality, marital status, pregnancy, physical or mental condition, genetic information, military service, or other characteristic protected by law.
