73 jobs found

Select how often (in days) to receive an alert: Data Scientist Country/Region: GB Connect with Eutelsat Group Be part of a new era in communications, transforming connectivity with Eutelsat Group - the world's first GEO-LEO integrated global satellite operator. As a leader in satellite communications, we provide global connectivity solutions - connecting businesses, communities, and governments around the world. We can connect you at on land, at sea and in the air. We also deliver broadcast television channels and packages, transmitting vital news reports around the world. With Eutelsat Group You'll Get To: Pioneer the future of Space Technology Bring connectivity to remote frontiers Collaborate with customer-centric experts Embrace cultural diversity in our global team In a dynamic industry where passion drives our teams to make a difference to become the most trusted partner for global satellite connectivity, you will elevate your skills in a stretching, rewarding, and meaningful environment. At Eutelsat Group, we're united by inclusion and diversity, striving for gender balance and social responsibility, on Earth and in Space. Why Eutelsat Group? Commitment to Diversity & Inclusion: With colleagues from over 75 countries, we embrace our global DNA and are committed to creating an inclusive workplace. We are proud that one-third of our executive team and 60% of our board are represented by women. Ways of Working That Drive Us : As "One Team," we work collaboratively towards shared goals, with customer-centricity, respect, and inclusivity as our guiding principles. Sustainability at Our Core: At Eutelsat Group, sustainability is more than just a word; it's woven into our strategy. We're dedicated to balancing social, environmental, and economic growth - both on Earth and in space. Work-Life Balance: We offer flexible schedules and hybrid/remote work options to help you balance your personal and professional life. At Eutelsat Group, we are committed to supporting your well-being and ensuring you have the flexibility you need to succeed both at work and at home. Ready to grow with us? Apply today and help us build a more inclusive, sustainable future in the world of satellite technology. Who You Are : You have general knowledge of IP, LTE and satellite communications. You're ready to roll up your sleeves and learn how the OneWeb system works in its details. You're a self-learner, ask questions and enjoy challenges. You feel comfortable with technical discussions in the presence of skilled customers. You know how to get traction, gain consensus, and communicate effectively. You want to make a real difference in the world by revolutionizing technology in Space. What You'll Do : You'll be part of a cross functional and cross departmental team, supporting the business by exploiting data Perform deep analysis of performance data and determine the best way to represent it visually to management, internal and external stakeholders. Proactive analysis of OneWeb system performance, to identify anomalies leading to substandard performance. Enhance system and service reporting to understand and communicate user experience with internal and external stakeholders. Keep automation at the forefront of all activities. Implement AI/ML to support service performance monitoring, reporting and root cause analysis. What It Takes : A degree in a quantitative discipline, such as Mathematics, Computer Science or equivalent. Demonstrated experience in data analysis (2+ years). Excellent verbal and written communication skills. Experience with and understanding of: Version control - Git, GitHub Use of databases - Snowflake, postgresql or mysql Data Science techniques - Machine Learning, Artificial Intelligence, Statistical algorithms Cloud technologies - AWS or GCP What We'd Love: Experience of working across functional teams Masters or PhD in applied data science. Where You'll Be : London, UK. Flexible remote working policy. The Eutelsat Group treats the protection of personal data submitted to it seriously. By submitting this application, you agree to the collection and retention of your personal data by the Eutelsat Group and acknowledge notice of, and understand the terms of Eutelsat's Privacy Policy (as amended from time to time). This role is a Eutelsat Group job opening; all of our open roles are posted on the current OneWeb and Eutelsat websites. Please note that when you are applying, your application may be seen by both teams.

At Basecamp Research, we're seeking a Head of AI to lead our team. Who we are & about this role We believe the future of biotech will combine diverse natural data sets with cutting-edge AI algorithms. We've built the largest ethically sampled biodiversity database and demonstrated state-of-the-art models in biology. After raising $60 million in Series B funding, we are expanding our team and resources to develop next-generation biological foundation models. This role involves steering our AI strategy, leading the AI team, and managing collaborations with academia and industry, including partnerships with major tech companies. You'll develop AI strategies based on innovative, science-driven data in a collaborative environment. Responsibilities Lead and manage a team of AI/ML researchers and engineers, fostering innovation Oversee development of novel AI/ML models and algorithms Collaborate with scientists, bioinformaticians, and engineers to define research goals and apply findings Manage multiple research projects aligned with company objectives Design AI system architecture, balancing research and production needs Provide thought leadership and mentorship within the team Represent Basecamp Research at conferences, publications, and collaborations About You (Required): Graduate degree in Computer Science, Machine Learning, Computational Biology, or related field 5+ years in AI/ML research or engineering, with at least 4 years in a technical lead or 3 years in management Strong publication record or expertise in generative AI, deep learning, or computational biology Experience applying AI to biological problems, especially protein design or genomics Proven success in leading AI research and translating it into practical applications Excellent communication skills for diverse audiences Experience training large generative models on HPC GPUs or cloud platforms like AWS, Lambda, Azure Strong problem-solving skills and critical thinking in AI research Strategic planning abilities Additional Skills (desired): Experience with protein or DNA bioinformatics MLOps expertise Software engineering skills, data pipelining (e.g., Airflow), cloud deployment experience Knowledge of Agile methodologies Interested in joining as our Head of AI? We look forward to hearing from you!

What if the work you did every day could impact the lives of people you know? Or all of humanity? At Illumina, we are expanding access to genomic technology to realize health equity for billions of people around the world. Our efforts enable life-changing discoveries that are transforming human health through the early detection and diagnosis of diseases and new treatment options for patients. Working at Illumina means being part of something bigger than yourself. Every person, in every role, has the opportunity to make a difference. Surrounded by extraordinary people, inspiring leaders, and world-changing projects, you will do more and become more than you ever thought possible. Senior Bioinformatics Scientist Cambridge Hub and Hybrid We have an exciting new opportunity for a talented Senior Bioinformatics Scientist to join our Illumina team based in Cambridge to support bringing the power of the genome to human health. This is a great opportunity to be part of Illumina's continued growth, contributing to our mission of improving human health by unlocking the power of the genome! Why us Our team specializes in developing a fast and accurate FPGA-accelerated platform called DRAGEN for the secondary analysis of NGS genomic data, together with integration in the ICA Cloud platform for scalability and data interpretation. The platform covers a wide range of pipelines including WGS and targeted (enriched/amplicon) germline, WGS and targeted somatic (T/N and tumor-only), DNA/RNA, small variants, CNV, and structural variants. Why you As a Senior Bioinformatics Scientist, you will be responsible for developing novel methods to extract biological meaning from genomic samples. You will design solutions and implement them in software in collaboration with others in a team-focused workflow. You will be responsible for helping to define and drive the success of the complete product, including defining requirements, assessing accuracy, streamlining customer experience, and enabling end-user applications. Key Responsibilities Design, prototype and implement innovative computational and/or statistical algorithms to extract meaningful biological signal from sequencing assays. Implement algorithms in production-grade C/C++ software. Collaborate deeply with inter-disciplinary teams (QC/QA test teams, FPGA teams, SW teams, clinical genomics teams) as the platform has many different end-users with different requirements and applications to ensure a smooth, end-to-end workflow with external organizations. Analyze, integrate, model and interpret experimental data. Engage with external customers' scientific teams to build product credibility and define emerging requirements. Clearly communicate technical methods and findings across internal teams with diverse expertise. Prepare internal and external facing technical documentation and marketing assets related to project research. Key experience and skills requirements You will have a strong background in computer science, algorithms, statistics, and/or digital signal processing in addition to expertise in genomics, next generation sequencing, and a broad ecosystem of related assays and biotechnologies. Our ideal candidate will have a track record of both innovative and pragmatic bioinformatics methods development and delivery, be a proven team player with leadership skills and experience and have the following: Expertise in genomics and experience with analyzing error modes and actionable signal in genomic data sets Expertise in algorithms for NGS secondary analysis: Mapping-Alignment and Variant Calling Expertise in high-performance software development using C++/C or similar languages Expertise in next generation sequencing assays and related biotechnology ecosystems. Expertise in common sequencing applications such as research in rare disease, cancer and population genetics. Experience/Education Ph.D. in computer science, engineering, statistics, bioinformatics, or related field of study, or a Master's degree in one of these fields with a minimum of 3 years of related experience. What can you expect Our team members are bright, energetic and dedicated - they are the driving force behind our innovation and impact. To attract the best and brightest, we offer a competitive employee benefits program. We view it as a smart investment in our people, one that recognizes the tremendous value they bring to our business every day. At Illumina, we push boundaries. We think beyond the conventional. We dream big. With the energy of so many bright and accomplished people, the opportunities are endless. Illumina believes that everyone has the ability to make an impact, and we are proud to be an equal opportunities employer committed to providing employment opportunity regardless of sex, race, creed, color, gender, religion, marital status, domestic partner status, age, national origin or ancestry, physical or mental disability, medical condition, sexual orientation, pregnancy, military or veteran status, citizenship status, and genetic information.

We are looking for a highly motivated candidate to join the Sequencing Methods Research Team as a Research Scientist to unlock transformative improvements in our molecular sensing capabilities. Oxford Nanopore Technologies is headquartered at the Oxford Science Park outside Oxford, UK, with satellite offices and commercial presence in many global locations across the US, APAC and Europe. Oxford Nanopore employs from multiple subject areas including nanopore science, molecular biology and applications, informatics, engineering, electronics, manufacturing and commercialisation. The management team, led by CEO Dr Gordon Sanghera, has a track record of delivering disruptive technologies to the market. Oxford Nanopore's sequencing platform is the only technology that offers real-time analysis (for rapid insights), in fully scalable formats from pocket to population scale, that can analyse native DNA or RNA and sequence any length of fragment to achieve short to ultra-long read lengths. Our goal is to enable the analysis of any living thing, by anyone, anywhere. We offer real-time nanopore-based DNA/RNA sequencing technology: accessible, easy to use and fully scalable for any requirement! We are seeking a highly motivated candidate to join our Sequencing Methods Research team. This exciting and stimulating role involves developing novel methods to deliver target analytes to our nanopore sensors and to control their movement through the nanopore to unleash the full potential of our unique platform. The details Design innovative experiments to characterise the behaviour of DNA and other analytes within our platforms Create and test new DNA-based adapters for optimal sample delivery Leverage the rich data generated by Oxford Nanopore devices to unlock new insights Work closely with multidisciplinary teams, from synthetic chemistry to platform engineering, to develop next-generation analyte delivery technologies What we are looking for Essential A PhD in Molecular Biology, Biophysics, Biochemistry, Chemistry, Biological Sciences, or related subjects OR 4+ years post-graduate experience in relevant industrial settings Solid understanding of protein and DNA structures Basic knowledge of the principles of nanopore sequencing Ability to quickly pick up new concepts and evaluate experimental design Desirable Single-molecule assay experience Strong data analysis skills Ability to comprehend and interpret complex and interconnected experimental results Experience with Python or R and the Linux command line Applications are encouraged from candidates who can adapt quickly to new situations and enjoy working with an agile approach to research. We offer outstanding benefits to include an attractive bonus, generous pension contributions, private healthcare and an excellent starting salary. Based within beautiful, landscaped surroundings with tree-lined walks, water features and a lake, all of which make for a wonderful working environment. If you are looking to utilise your skills to really make a difference to humankind, then consider joining our team and apply today! We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, colour, national origin, sex, gender, gender expression, sexual orientation, age, marital status, veteran status, or disability status. We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation. Please note that no terminology in this advert is intended to discriminate on the grounds of a person's gender, marital status, race, religion, colour, age, disability or sexual orientation. Every candidate will be assessed only in accordance with their merits, qualifications and abilities to perform the duties of the job.

The Ellison Institute of Technology (EIT) Oxford tackles humanity's greatest challenges by turning science and technology into impactful global solutions. Focused on areas like health, food security, sustainable agriculture, climate change, clean energy, and AI-driven government innovation, EIT Oxford blends groundbreaking research with practical applications to deliver lasting results. A cornerstone of EIT Oxford's mission is its upcoming 300,000-square-foot research facility at the Oxford Science Park, set to open in 2027. This cutting-edge campus will feature advanced labs, an oncology and preventative care clinic, and collaborative spaces to strengthen its partnership with the University of Oxford. It will also host the Ellison Scholars, driving innovation for societal benefit. The Pathogen Mission highlights EIT's transformative approach, using Whole Genome Sequencing (WGS) and Oracle's cloud technology to create a global pathogen metagenomics system. This initiative aims to improve diagnostics, provide early epidemic warnings, and guide treatments by profiling antimicrobial resistance. The goal is to deliver certified diagnostic tools for widespread use in labs, hospitals, and public health. EIT Oxford fosters a culture of collaboration, innovation, and resilience, valuing diverse expertise to drive sustainable solutions to humanity's enduring challenges. We are seeking a Senior Scientist, Microfluidics to support the research and product development of EIT Oxford's Pathogen Programme. The lab-based role involves designing, fabricating and testing microfluidic flow cells for the extraction of DNA and other relevant biological substances from microbial pathogens (bacteria, viruses, fungi and other eukaryotes) from clinical and other sources to inform the diagnosis and treatment of infectious disease in humans. The role will involve working with other scientists and engineers in small teams to deliver the project milestones. The postholder includes prototyping fluidic array structures for the movement of small fluid volumes between reaction and purification chambers, fabrication of these arrays for evaluation purposes, designing and performing tests to evaluate the performance of the microfluidic array for DNA extraction and manipulation. Ideal candidates will have expertise in microfluidics, MEMs fabrication, analytical chemistry, and assay development. Experience working with biological samples and DNA would be beneficial. Key Responsibilities: Research, development, and optimisation of microfluidic systems for DNA extraction from biosamples, and the subsequent purification and DNA manipulation. Design and execute experiments for device characterisation, fluid dynamics analysis, and performance validation. Develop and run protocols for fabrication, assembly, and testing of microfluidic devices. Optimise the array and flow cell performance for high yields, greater ease of use and robustness. Contribute to intellectual property generation, including patents and technical disclosures. Prepare technical documentation, reports, and presentations for internal stakeholders and external collaborators. Qualifications & Experience: 2+ years industry experience and PhD or equivalent experience in Engineering, Physics, Bioengineering, or related field with specialisation in microfluidics, MEMS, or lab-on-a-chip systems. Hands-on experience with microfabrication techniques such as soft lithography, photolithography, CNC micromilling, injection moulding, or 3D microprinting. Proven ability to design and execute experiments to characterise microfluidic systems (e.g., flow profiling, pressure measurements, mixing efficiency, droplet generation). Skilled in integrating microfluidics with sensors, optics, electronics, or automation platforms. Desirable Knowledge, Skills and Experience: Familiarity with biological or biochemical applications in microfluidics (e.g., single-cell analysis, droplet microfluidics, bead handling, point-of-care diagnostics, organ-on-chip). Experience in troubleshooting and optimizing fluidic workflows in complex systems. Familiarity with microscopy and imaging techniques relevant to microfluidics (e.g., fluorescence, brightfield, confocal). Experience of developing technologies within regulatory frameworks for in vitro diagnostics within the UK, EU or USA. We offer the following salary and benefits: Salary: Competitive salary on offer Enhanced holiday pay Pension Life Assurance Income Protection Private Medical Insurance Hospital Cash Plan Therapy Services Perk Box Electrical Car Scheme Why work for EIT: At the Ellison Institute, we believe a collaborative, inclusive team is key to our success. We are building a supportive environment where creative risks are encouraged, and everyone feels heard. Valuing emotional intelligence, empathy, respect, and resilience, we encourage people to be curious and to have a shared commitment to excellence. Join us and make an impact! Terms of Appointment: You must have the right to work permanently in the UK with a willingness to travel as necessary. You will live in, or within easy commuting distance of, Oxford. During peak periods, some longer hours may be required and some working across multiple time zones due to the global nature of the programme.

The Ellison Institute of Technology (EIT) Oxford tackles humanity's greatest challenges by turning science and technology into impactful global solutions. Focused on areas like health, food security, sustainable agriculture, climate change, clean energy, and AI-driven government innovation, EIT Oxford blends groundbreaking research with practical applications to deliver lasting results. A cornerstone of EIT Oxford's mission is its upcoming 300,000-square-foot research facility at the Oxford Science Park, set to open in 2027. This cutting-edge campus will feature advanced labs, an oncology and preventative care clinic, and collaborative spaces to strengthen its partnership with the University of Oxford. It will also host the Ellison Scholars, driving innovation for societal benefit. The Pathogen Mission highlights EIT's transformative approach, using Whole Genome Sequencing (WGS) and Oracle's cloud technology to create a global pathogen metagenomics system. This initiative aims to improve diagnostics, provide early epidemic warnings, and guide treatments by profiling antimicrobial resistance. The goal is to deliver certified diagnostic tools for widespread use in labs, hospitals, and public health. EIT Oxford fosters a culture of collaboration, innovation, and resilience, valuing diverse expertise to drive sustainable solutions to humanity's enduring challenges. We are seeking a Scientist, Microfluidics to support the research and product development of EIT Oxford's Pathogen Programme. The lab-based role involves designing, fabricating, and testing microfluidic flow cells for the extraction of DNA and other relevant biological substances from microbial pathogens (bacteria, viruses, fungi, and other eukaryotes) from clinical and other sources to inform the diagnosis and treatment of infectious disease in humans. The role will involve working with other scientists and engineers in small teams to deliver the project milestones. The postholder includes prototyping fluidic array structures for the movement of small fluid volumes between reaction and purification chambers, fabrication of these arrays for evaluation purposes, designing and performing tests to evaluate the performance of the microfluidic array for DNA extraction and manipulation. In addition, working with external partners to assist in the scale-up of successful array designs. Ideal candidates will have expertise in microfluidics, MEMs fabrication, analytical chemistry, and assay development. In addition, they will have a track record of working with small, innovative teams to test, iterate, and embed new capabilities. Experience working with biological samples and DNA would be beneficial. Key Responsibilities: Drive the design, development, and optimisation of microfluidic systems for DNA extraction from biosamples, and the subsequent purification and DNA manipulation. Design and execute experiments for device characterisation, fluid dynamics analysis, and performance validation. Translate product requirements into technical specifications for microfluidic components. Implement protocols for fabrication, assembly, and testing of microfluidic devices. Mentor junior scientists and engineers; provide technical guidance and project leadership. Contribute to intellectual property generation, including patents and technical disclosures. Prepare technical documentation, reports, and presentations for internal stakeholders and external collaborators. Qualifications & Experience: PhD or equivalent in Engineering, Physics, Bioengineering, or related field with specialisation in microfluidics, MEMS, or lab-on-a-chip systems. Deep understanding of microfluidic principles, including fluid dynamics, laminar flow, diffusion, and surface tension effects in microscale systems. Hands-on experience with microfabrication techniques such as soft lithography, photolithography, CNC micro milling, injection moulding, or 3D microprinting. Proven ability to design and execute experiments to characterize microfluidic systems (e.g., flow profiling, pressure measurements, mixing efficiency, droplet generation). Skilled in integrating microfluidics with sensors, optics, electronics, or automation platforms. Desirable Knowledge, Skills and Experience: Familiarity with biological or biochemical applications in microfluidics (e.g., single-cell analysis, droplet microfluidics, bead handling, point-of-care diagnostics, organ-on-chip). Experience in troubleshooting and optimizing fluidic workflows in complex systems. Familiarity with microscopy and imaging techniques relevant to microfluidics (e.g., fluorescence, brightfield, confocal). Experience of developing technologies within regulatory frameworks for in vitro diagnostics within the UK, EU, or USA. We offer the following salary and benefits: Salary: Enhanced holiday pay Pension Life Assurance Income Protection Private Medical Insurance Hospital Cash Plan Therapy Services Perk Box Electrical Car Scheme Why work for EIT: At the Ellison Institute, we believe a collaborative, inclusive team is key to our success. We are building a supportive environment where creative risks are encouraged, and everyone feels heard. Valuing emotional intelligence, empathy, respect, and resilience, we encourage people to be curious and to have a shared commitment to excellence. Join us and make an impact! Terms of Appointment: You must have the right to work permanently in the UK with a willingness to travel as necessary. You will live in, or within easy commuting distance of, Oxford. During peak periods, some longer hours may be required and some working across multiple time zones due to the global nature of the programme.

Job Description Oxford Nanopore Technologies is headquartered at the Oxford Science Park outside Oxford, UK, with satellite offices and a commercial presence in many global locations across the US, APAC, and Europe. Oxford Nanopore employs experts from multiple subject areas including nanopore science, molecular biology and applications, informatics, engineering, electronics, manufacturing, and commercialization. The management team, led by CEO Dr. Gordon Sanghera, has a track record of delivering disruptive technologies to the market. Oxford Nanopore's sequencing platform is unique, offering real-time analysis in fully scalable formats from pocket to population scale, capable of analyzing native DNA or RNA and sequencing any length of fragment to achieve short to ultra-long read lengths. Our goal is to enable the analysis of any living thing, by anyone, anywhere! The Role Our Biologics Development team is responsible for improving the performance of all biological components within our sample preparation kits and flowcells. We are seeking a highly motivated individual with excellent lab skills to join as a Development Scientist. As part of the wider R&D division, we collaborate to deliver new chemistries from conception to customers. This role, based at our Oxford headquarters, will support the development of new nanopore sequencing products, focusing on enhancing fundamental performance metrics to improve outcomes and utility for users of the ONT platform. The successful candidate will be responsible for designing, purifying, and analyzing key protein components that form the backbone of RNA and DNA sequencing chemistries, as well as future nanopore sensing applications. You will interact with various stakeholders across R&D and product divisions in a multidisciplinary environment. What We're Looking For We seek a motivated and detail-oriented candidate with experience in: Biochemical properties of proteins, especially DNA/RNA handling enzymes and membrane proteins. Recombinant protein expression from bacterial systems. Lab-scale purification of proteins using chromatographic methods with AKTA or similar systems. Experimental design and execution focusing on protein function. Targeted chemical modification of proteins. Programming skills in Python, R, or command line for data science. Additional experience in one or more of the following is a plus: Nanopore sensing experiments. Computational tools for protein variant design. Responsibilities Designing and iterating protein variants to improve nanopore sensing performance. Expressing and purifying protein variants at appropriate scales, troubleshooting as needed. Characterizing proteins using biochemical techniques and nanopore-based assays. Analyzing data thoroughly and reporting findings accurately to the team. The ideal candidate will hold a PhD in biochemistry, chemistry, or a related field, or equivalent industrial experience. We value strong attention to detail, organization, and effective communication skills. This role is suited for a dedicated individual eager to learn and grow, with extensive training and mentorship provided. We offer excellent benefits, including a bonus, generous pension contributions, private healthcare, and a competitive salary. Our workspace is in a beautiful environment with landscaped surroundings, water features, and a lake, providing a pleasant working atmosphere. If you want to make a difference through your skills, consider joining our team. Apply today! We are committed to diversity and equal opportunity, assessing all candidates based on merit, qualifications, and ability to perform the job.

ABOUT THE ROLE At DSV we're looking for future Founders, entrepreneurially minded individuals with industry-specific technical and commercial domain expertise eager to solve urgent unmet challenges through venture building. You will join DSV's venture creation programme as a Founder in Residence and work closely with the DSV team, using our methodology , to spin-out a new company. During the programme, you'll work on all aspects related to venture creation in this opportunity area, including working out the optimal approach to solve for the desired outcome, building a team and building a viable business case. Once the new venture is incorporated with pre-seed investment from DSV, you and your co-founders will own the majority stake in the business and continue receiving support from the DSV team post-spinout. The role is full-time, fully remote until venture incorporation and spin-out, after - TBD. THE OPPORTUNITY AREA Over 6 million individuals live with Parkinson's disease (PD) today, and this number is projected to reach 12 million globally by 2040 as populations age. Whilst current therapies do offer symptomatic relief from debilitating motor symptoms, no clinically approved drug intervenes at root cause, meaning disease progression cannot be prevented. In addition, emerging therapeutics which show great promise in animal models of PD often fail to translate in the clinical setting, with even the most successful clinical trials reporting incremental benefit, often capped by dose limiting toxicity. To address this, we are partnering with Parkinson's UK to develop precise, next generation therapies which target true disease modifying nodes in previously unimagined ways. As PD is a multi-pathway pathology, spanning oxidative stress, impaired autophagy, mitochondrial dysfunction and neuroinflammation, the efficacy of single pathway approaches is constrained. OUR APPROACH We are designing a therapeutic approach that will target master homeostatic regulators which can simultaneously correct numerous PD pathways, changing the course of disease. We believe this has the potential to transform patient lives by slowing, halting or even reversing disease progression. This pathway has been the focus of drug development in the past but not been drugged successfully through classic approaches. We are looking to unlock this through the use of novel modalities and a clever target selection and targeting strategy that has the potential to overcome the many feedback looks regulating this pathway. WHO SHOULD APPLY Essential (must-have): PhD in neuroscience or other field relevant to the project; Extensive, systems-level knowledge of Parkinson's disease, including at the cellular and molecular level; Expertise in oxidative stress and/or neuroprotective pathways; Experience in cellular, molecular and/or biochemical approaches to drug discovery for CNS disorders; Experience working in biotech/pharma or an alternative setting which requires strong commercial awareness and understanding of the drug development process; Entrepreneurial spirit, likely demonstrated through impactful innovation; You are innovative, creative, and guided by first-principles thinking; You are highly motivated to create curative solutions for PD patients. Preferred (nice-to-have): Broad knowledge of brain-specific drug delivery techniques; Experience in nucleic acid based payloads (ASO/siRNA/DNA) and delivery techniques; Track record of high quality publications in the field, or thought leadership in the field; High level industry experience in either pharma, biotech, scientific start-ups, life sciences consulting, life sciences VC, or have previously been an inventor/contributor on patents, etc.; Fundraising experience at seed and Series A stages, with established investor contacts. OUR OFFER By joining DSV, you'll be joining a team of operators who have founded companies and led translation of science at some of the most respected universities, charities, funds and government agencies. 2/3 of the team have founded or led a company at C-suite and 65% have a PhD. Our team dedicate several hours every week to each Founder/founding team to provide tailored guidance, resources and feedback covering every aspect of what it takes to successfully launch a new venture from both the tech and commercial perspectives: We provide optimised, purpose-built, proprietary tools, resources and processes to help create high-impact ventures from scratch, using our venture creation methodology; We draw on opportunity area specific know-how provided by our Partner organisation - Parkinson's UK - working collaboratively with their team of experts and Advisors; We provide £250k launch investment (subject to Investment Committee approval) to incorporate the new venture and develop early proof-of-concept data that's needed to attract high profile VCs as well as non-dilutive grant funding; We provide guaranteed income of £4,166 per month paid to each Founder-in-Residence as a fixed consultancy fee until the company is launched and the pre-seed investment is secured; You and the current Founder-in-Residence, together with any additional co-founders, will collectively own a majority equity stake in the company; We provide continuous support after post spin-out, including fundraising, commercial partnerships, recruitment and team-building (amongst other things); plus There are dozens of Founders currently at DSV across sectors working collaboratively and supporting one another - a unique resource to draw on. WHO YOU'LL BE JOINING You will be joining Dr. Kiren Baines-Mortimore, an accomplished scientific leader with many years of experience across drug discovery and development. Kiren, is the former co-founder and CSO at Extracellular, a cultivated meat CDMO. Prior to founding Extracellular, Kiren was the Analytical Development and Quality Control Lead at eXmoor Pharma,where she supported clients in the cell and gene therapy sector with process and analytical development, manufacturing, and commercialization. Earlier in her career, Kiren contributed to drug discovery initiatives at Charles River Laboratories. Kiren earned her PhD in Cell Biology from the University of Bristol. Kiren's background in Parkinson's combined with her expertise in drug development, along with her outstanding professionalism and ambition, makes her a top talent to work with. ABOUT DSV Deep Science Ventures is creating a future in which both humans and the planet can thrive. We use our unique venture creation process to create, spin-out and invest into science companies, combining available scientific knowledge and founder-type scientists into high-impact ventures. We operate in 4 sectors: Pharmaceuticals, Climate, Agriculture and Computation, tackling the challenges defining those areas by taking a first principles approach and partnering with leading institutions. ABOUT OUR PARTNERSHIP WITH PARKINSON'S UK In a landmark collaboration that marries scientific prowess with an unwavering dedication to improving patient lives, Deep Science Ventures, an avant-garde venture creator headquartered in London, has announced a pioneering partnership with Parkinson's UK , the leading charity driving better care, treatments, and quality of life for those affected by Parkinson's. This strategic alliance is set to merge DSV's unique invention method with Parkinson's UK's rich insights into patient care, igniting the creation of a new, dedicated company. The aim is to propel the most innovative and efficient therapeutic approach into real-world application, funded by the transformative Parkinson's Virtual Biotech initiative - Parkinson's UK investment arm.

Location : London (Hammersmith) Reporting to :Director, Viral Vector Development Orchard Therapeutics, a Kyowa Kirin company, is a global gene therapy leader focused on transforming the life of patients with rare disorders through innovative gene therapies based on gene-modified hematopoietic stem cell (HSC). Orchard has its global headquarters in London and U.S. headquarters in Boston. Technical Development sits within Technical Operations at Orchard and is responsible for the development and characterization of Lentiviral Vectors (LVVs) and DS/DP production processes, which meet patient demand for therapeutic products of the best quality. Reporting to the Director, Viral Vector Development, the Principal Scientist, Viral Vector Development, will be responsible for the development of innovative, high-yield processes for production of LVVs for the defined project(s). The candidate will closely interact with other functional groups including analytics, cell process development, CMC and regulatory teams. This role is based in our Hammersmith, London facilities within our global headquarters and will suit candidates who would like to join a global company with a diverse and dynamic work environment that provides opportunities for sustained personal and professional growth. Key Elements and Responsibilities Design, develop and improve upstream and downstream processes for LVVs to deliver robust manufacturing platforms for early and late-stage clinical and commercial development Execute experimental plans, analyse experimental data and write technical reports Provide hands-on technical expertise/scientific guidance to team members and supervision of junior colleagues Contribute to the transfer of improved processes to GMP and assist with oversight of manufacturing activities as required Assist in the reporting, investigation and resolution of deviations encountered during GMP production activities Prepare, review and complete protocols/SOPs, study reports and assist with regulatory submissions Communicate, share and discuss work progress internally and externally Perform landscape scouting to drive continuous improvement in quality, yield and COGs Provide expert review and approval of executed batch, records, test records and associated documentation for release of LVVs and plasmids used in their production. Experience & Knowledge In-depth knowledge of state-of-the-art cell & gene therapy products and available technologies, more specifically regarding viral vectors Minimum of 5 years of experience with development, manufacture and delivery of viral vectors, preferably retro and lentiviral vectors including late phase product development Experience with risk-based approaches, such as Failure Modes and Effects Analysis Demonstrated skills and experience in adherent and suspension cell lines in different culture systems Demonstrated knowledge in designing and developing processes for LVV production and purification Experience in process characterization and validation of the large-scale cGMP production of lentiviral vectors Experience with specialised lab equipment e.g. bioreactors, AKTA, TFF systems, etc Proficiency with MS office, MFCS, SnapGene, Unicorn, e-lab books and other commonly used software is required. Experience with DoE software (s) and statistical analysis would be ideal. Knowledge of FDA, EMA, GMP and ICH regulatory requirements Knowledge of Quality Systems and QBD as they relate to GMP production operations, process optimization and process validation. Knowledge of statistical data analysis Knowledge of plasmid DNA manufacturing would be an asset. Skills and Abilities Demonstrated skills and capability in planning, preparing, executing and reporting of process development and validation activities. Ability to operate in a fast paced, multidisciplinary industrial environment Creativeness, motivation, and troubleshooting skills to solve problems and/or develop new technical capabilities Excellent interpersonal and communication skills Ability to visualize / present data in order to communicate ideas, concepts and results to technical and non-technical audiences. Ability to independently design and appropriately analyse data and provide an interpretation of results Strong organization and planning skills to prioritise work and meet deadlines Education PhD, BSc or equivalent in biotechnology, process development, cell and gene therapy, biological sciences, or other relevant scientific disc

The Ellison Institute of Technology (EIT) Oxford tackles humanity's greatest challenges by turning science and technology into impactful global solutions. Focused on areas like health, food security, sustainable agriculture, climate change, clean energy, and AI-driven government innovation, EIT Oxford blends groundbreaking research with practical applications to deliver lasting results. A cornerstone of EIT Oxford's mission is its upcoming 300,000-square-foot research facility at the Oxford Science Park, set to open in 2027. This cutting-edge campus will feature advanced labs, an oncology and preventative care clinic, and collaborative spaces to strengthen its partnership with the University of Oxford. It will also host the Ellison Scholars, driving innovation for societal benefit. The Pathogen Mission highlights EIT's transformative approach, using Whole Genome Sequencing (WGS) and Oracle's cloud technology to create a global pathogen metagenomics system. This initiative aims to improve diagnostics, provide early epidemic warnings, and guide treatments by profiling antimicrobial resistance. The goal is to deliver certified diagnostic tools for widespread use in labs, hospitals, and public health. EIT Oxford fosters a culture of collaboration, innovation, and resilience, valuing diverse expertise to drive sustainable solutions to humanity's enduring challenges. We are seeking a Senior Scientist, Microfluidics to support the research and product development of EIT Oxford's Pathogen Programme. The lab-based role involves designing, fabricating and testing microfluidic flow cells for the extraction of DNA and other relevant biological substances from microbial pathogens (bacteria, viruses, fungi and other eukaryotes) from clinical and other sources to inform the diagnosis and treatment of infectious disease in humans. The role will involves working with other scientists and engineers in small teams to deliver the project milestones. The postholder includes prototyping fluidic array structures for the movement of small fluid volumes between reaction and purification chambers, fabrication of these arrays for evaluation purposes, designing and performing tests to evaluate the performance of the microfluidic array for DNA extraction and manipulation. Ideal candidates will have expertise in microfluidics, MEMs fabrication, analytical chemistry, assay development. Experience working with biological sample and DNA would be beneficial. Key Responsibilities: Research, development, and optimisation of microfluidic systems for DNA extraction from biosamples, and the subsequent purification and DNA manipulation. Design and execute experiments for device characterisation, fluid dynamics analysis, and performance validation. Develop and run protocols for fabrication, assembly, and testing of microfluidic devices. Optimise the array and flow cell performance for high yields, greater ease of use and robustness. Contribute to intellectual property generation, including patents and technical disclosures. Prepare technical documentation, reports, and presentations for internal stakeholders and external collaborators. Qualifications & Experience: 2+ years industry experience and PhD or equivalent experience in Engineering, Physics, Bioengineering, or related field with specialisation in microfluidics, MEMS, or lab-on-a-chip systems Hands-on experience with microfabrication techniques such as soft lithography, photolithography, CNC micromilling, injection moulding, or 3D microprinting. Proven ability to design and execute experiments to characterise microfluidic systems (e.g., flow profiling, pressure measurements, mixing efficiency, droplet generation). Skilled in integrating microfluidics with sensors, optics, electronics, or automation platforms. Desirable Knowledge, Skills and Experience: Familiarity with biological or biochemical applications in microfluidics (e.g., single-cell analysis, droplet microfluidics, bead handling, point-of-care diagnostics, organ-on-chip). Experience in troubleshooting and optimizing fluidic workflows in complex systems. Familiarity with microscopy and imaging techniques relevant to microfluidics (e.g., fluorescence, brightfield, confocal). Experience of developing technologies within regulatory frameworks for in vitro diagnostics within the UK, EU or USA. We offer the following salary and benefits: Salary: Competitive salary on offer Enhanced holiday pay Pension Life Assurance Income Protection Private Medical Insurance Hospital Cash Plan Therapy Services Perk Box Electrical Car Scheme Why work for EIT: At the Ellison Institute, we believe a collaborative, inclusive team is key to our success. We are building a supportive environment where creative risks are encouraged, and everyone feels heard. Valuing emotional intelligence, empathy, respect, and resilience, we encourage people to be curious and to have a shared commitment to excellence. Join us and make an impact! Terms of Appointment: You must have the right to work permanently in the UK with a willingness to travel as necessary. You will live in, or within easy commuting distance of, Oxford. During peak periods, some longer hours may be required and some working across multiple time zones due to the global nature of the programme.

The Ellison Institute of Technology (EIT) Oxford tackles humanity's greatest challenges by turning science and technology into impactful global solutions. Focused on areas like health, food security, sustainable agriculture, climate change, clean energy, and AI-driven government innovation, EIT Oxford blends groundbreaking research with practical applications to deliver lasting results. A cornerstone of EIT Oxford's mission is its upcoming 300,000-square-foot research facility at the Oxford Science Park, set to open in 2027. This cutting-edge campus will feature advanced labs, an oncology and preventative care clinic, and collaborative spaces to strengthen its partnership with the University of Oxford. It will also host the Ellison Scholars, driving innovation for societal benefit. The Pathogen Mission highlights EIT's transformative approach, using Whole Genome Sequencing (WGS) and Oracle's cloud technology to create a global pathogen metagenomics system. This initiative aims to improve diagnostics, provide early epidemic warnings, and guide treatments by profiling antimicrobial resistance. The goal is to deliver certified diagnostic tools for widespread use in labs, hospitals, and public health. EIT Oxford fosters a culture of collaboration, innovation, and resilience, valuing diverse expertise to drive sustainable solutions to humanity's enduring challenges. We are seeking a Scientist, Microfluidics to support the research and product development of EIT Oxford's Pathogen Programme. The lab-based role involves designing, fabricating and testing microfluidic flow cells for the extraction of DNA and other relevant biological substances from microbial pathogens (bacteria, viruses, fungi and other eukaryotes) from clinical and other sources to inform the diagnosis and treatment of infectious disease in humans. The role will involves working with other scientists and engineers in small teams to deliver the project milestones. The postholder includes prototyping fluidic array structures for the movement of small fluid volumes between reaction and purification chambers, fabrication of these arrays for evaluation purposes, designing and performing tests to evaluate the performance of the microfluidic array for DNA extraction and manipulation. In addition, working with external partners to assist in the scale-up of successful array designs. Ideal candidates will have expertise in microfluidics, MEMs fabrication, analytical chemistry, assay development. In addition, they will have a track record of working with small, innovative teams to test, iterate and embed new capabilities. Experience working with biological sample and DNA would be beneficial. Key Responsibilities: Drive the design, development, and optimisation of microfluidic systems for DNA extraction from biosamples, and the subsequent purification and DNA manipulation. Design and execute experiments for device characterisation, fluid dynamics analysis, and performance validation. Translate product requirements into technical specifications for microfluidic components. Implement protocols for fabrication, assembly, and testing of microfluidic devices. Mentor junior scientists and engineers; provide technical guidance and project leadership. Contribute to intellectual property generation, including patents and technical disclosures. Prepare technical documentation, reports, and presentations for internal stakeholders and external collaborators. Qualifications & Experience: PhD or equivalent in Engineering, Physics, Bioengineering, or related field with specialisation in microfluidics, MEMS, or lab-on-a-chip systems Deep understanding of microfluidic principles, including fluid dynamics, laminar flow, diffusion, and surface tension effects in microscale systems. Hands-on experience with microfabrication techniques such as soft lithography, photolithography, CNC micro milling, injection moulding, or 3D microprinting. Proven ability to design and execute experiments to characterize microfluidic systems (e.g., flow profiling, pressure measurements, mixing efficiency, droplet generation). Skilled in integrating microfluidics with sensors, optics, electronics, or automation platforms Desirable Knowledge, Skills and Experience: Familiarity with biological or biochemical applications in microfluidics (e.g., single-cell analysis, droplet microfluidics, bead handling, point-of-care diagnostics, organ-on-chip). Experience in troubleshooting and optimizing fluidic workflows in complex systems. Familiarity with microscopy and imaging techniques relevant to microfluidics (e.g., fluorescence, brightfield, confocal). Experience of developing technologies within regulatory frameworks for in vitro diagnostics within the UK, EU or USA. We offer the following salary and benefits: Salary: Enhanced holiday pay Pension Life Assurance Income Protection Private Medical Insurance Hospital Cash Plan Therapy Services Perk Box Electrical Car Scheme Why work for EIT: At the Ellison Institute, we believe a collaborative, inclusive team is key to our success. We are building a supportive environment where creative risks are encouraged, and everyone feels heard. Valuing emotional intelligence, empathy, respect, and resilience, we encourage people to be curious and to have a shared commitment to excellence. Join us and make an impact! Terms of Appointment: You must have the right to work permanently in the UK with a willingness to travel as necessary. You will live in, or within easy commuting distance of, Oxford. During peak periods, some longer hours may be required and some working across multiple time zones due to the global nature of the programme.

Hours per week 37 Project Title Computational Modelling of Epigenetic Dynamics Expected/Ideal Start Date 01 Oct 2025 Months Duration 36 Job Description Main Purpose of the Job Applications are invited for a Postdoctoral Researcher to join the group of Prof Martin Howard in the Department of Computational and Systems Biology at the John Innes Centre, Norwich, UK. The main purpose of the position is to develop computational models of epigenetic dynamics in the Polycomb system, collaborating with the experimental group of Prof Rob Klose (Oxford). Key Relationships Other members of the Howard group, other groups within Computational and Systems Biology at JIC, and other external experimental groups, particularly that of Prof. Rob Klose in the Dept of Biochemistry, Oxford University. Main Activities & Responsibilities Percentage Identify, plan, carry out and modify modelling to meet the objectives of the project 50 Prepare results, reports and manuscripts for publication in leading scientific journals and other relevant media 20 Disseminate research findings through presentations to various audiences at internal, national and international meetings 10 Ensure research and record keeping is carried out in accordance with good practice, Scientific Integrity and in compliance with local policies and any legal requirements 5 Contribute to the smooth running of the group, including the effective use of resources, supervision of visitors to the laboratory and assisting with training others, encouraging scientific excellence 5 Continually strive for excellence, seeking out and acting on feedback and relevant learning and development opportunities 5 As agreed with the line manager, any other duties commensurate with the nature of the post, for example, contributing to the work of Institute committees 5 Person Profile Education & Qualifications Requirement Importance PhD (full award or expected within 6 months) in Theoretical Physics/Bio-Mathematics/Computational Biology Essential BSc or equivalent in a relevant scientific field Essential Specialist Knowledge & Skills Requirement Importance Ability to apply techniques from theoretical physics/applied mathematics to biological problems Essential Strong interest in biological problems Essential Computer programming experience (e.g. use of computational tools such as MatLab) Desirable Requirement Importance Demonstrable scientific success, with track-record of publications and presentations Essential Prior experience in biological modelling Desirable Interpersonal & Communication Skills Requirement Importance Self-motivated, creative and intellectually independent Essential Good verbal and written communication skills, facilitating interaction with experimentalists Essential Ability to collaborate with internal and external stakeholders Essential Excellent time management and organisational skills Essential Good interpersonal skills, with the ability to work well as part of a team Essential Additional Requirements Requirement Importance Available to travel to international meetings and for short visits to collaborating laboratories Essential Willingness to work outside standard working hours when required Essential Attention to detail Essential Promotes equality and values diversity Essential Willingness to embrace the expected values and behaviours of all staff at the Institute, ensuring it is a great place to work Essential Able to present a positive image of self and the Institute, promoting both the international reputation and public engagement aims of the Institute Essential Who We Are The John Innes Centre is an independent, international centre of excellence in plant and microbial genetics, carrying out fundamental and strategic research, to train scientists and making our findings available to society. Our research makes use of a wide range of disciplines in the biological and chemical sciences including; cell biology, biochemistry, chemistry, genetics and molecular biology. We pride ourselves on being a welcoming and inclusive working environment for all. We have a diverse and multicultural scientific community and thrive on our European and international links, appointing staff from across the world. Any candidate who would like further information on current or anticipated immigration requirements can contact the HR Team on (0) or . We are proud to hold a prestigious Athena SWAN Gold award , recognising the impact of our work in promoting gender equality in science. We are also a proud member of the Stonewall Diversity Champion's programme , a founding signatory of the Tecnician Commitment and, as a Disability Confident employer, guarantee to offer an interview to all disabled applicants who meet the essential criteria for the post. The John Innes Centre is a registered charity (No. 223852), limited by guarantee (registered in England No. 511709). Department Computational and Systems Biology The Department of Computational and Systems Biology conducts world-leading research across a broad range of the biological sciences, with a special focus on spatial problems in plant and microbial research. Particular strengths of the department include mathematical and statistical modelling of the physical mechanisms underlying biological pattern formation, transport dynamics, epigenetic processes, size control, biomechanics and gene network dynamics. In addition, the department has strong bioinformatics that underpins the research of the institute through training, software development and statistical analysis. While much of the research is carried out in close collaboration with world-leading experimental groups within the John Innes Centre, we also have strong international collaborations with experimentalists and theoreticians worldwide. The Howard group combines simple, predictive mathematical and biophysical modelling with long-lasting experimental collaborations to dissect biological mechanisms too complex to unravel by experiments alone. In many cases we are able to rationalise complex biological dynamics into simple underlying mechanisms, with few components and interactions. Our approach is highly interdisciplinary and relies heavily on the techniques of statistical physics and applied mathematics, as well as on close collaboration with experimental groups. This truly interdisciplinary approach allows us to get to the heart of biological mechanisms more speedily. At present there are two main foci in the group: probing how epigenetic memory states are set up and then stably maintained, and understanding patterning dynamics in sub-cellular biological systems. For epigenetics, we work on both histone modification memory systems, including the Polycomb system, as well as on DNA methylation. For patterning, the main application at present is to the dynamics of crossover positioning in meiosis. The group collaborates with a wide range of experimentalists in systems ranging from plants to mammalian stem cells. Currently there are three Postdoctoral Researchers in the group. Postdoctoral Researcher Salary: £36,720 - £39,750 per annum depending on qualifications and experience. Contract: 36 months, full-time Location: John Innes Centre, Norwich, UK. Closing date: 2 August 2025 Reference: An exciting opportunity has arisen for a Postdoctoral Researcher to join the Howard Group at the John Innes Centre, working on cutting-edge science in the field of Computational and Systems Biology. About the John Innes Centre: The John Innes Centre is an independent, international centre of excellence in plant and microbial sciences. We nurture a creative, curiosity-led approach to answering fundamental questions in bioscience, and translate that knowledge into societal benefits. Our strategic vision, Healthy Plants, Healthy People, Healthy Planet , sets out our ambitious long-term goals for the game changing impact of our science globally. Our employees enjoy access to state-of-the-art technology and a diverse range of specialist training opportunities, including support for leadership and management. Click here to find out more about working at the John Innes Centre. About the Howard Group: The Howard group combines simple, predictive mathematical and biophysical modelling with long-lasting experimental collaborations to dissect biological mechanisms too complex to unravel by experiments alone. In many cases we are able to rationalise complex biological dynamics into simple underlying mechanisms, with few components and interactions. Our approach is highly interdisciplinary and relies heavily on the techniques of statistical physics and applied mathematics, as well as on close collaboration with experimental groups. At present there are two main research areas in the group: probing how epigenetic memory states are set up and then stably maintained, and understanding patterning dynamics in sub-cellular biological systems. For epigenetics, we work on both histone modification memory systems, particularly the Polycomb silencing system, as well as on DNA methylation. For patterning, the main application at present is to the dynamics of crossover positioning in meiosis. The group regularly publishes in the most prominent multidisciplinary journals, with recent papers in Nature, Science, Cell Systems, eLife, Molecular Cell and PNAS. Several previous members of the Howard group now hold independent faculty positions of their own, including in Warwick, Glasgow, Sydney, Amsterdam and Munich. The role: . click apply for full job details

Oxford Nanopore Technologies: Our goal is to bring the widest benefits to society through enabling the analysis of anything, by anyone, anywhere. The company has developed a new generation of nanopore-based sensing technology for faster, information rich, accessible and affordable molecular analysis. The first application is DNA/RNA sequencing, and the technology is in development for the analysis of other types of molecules including proteins. The technology is used to understand and characterise the biology of humans and diseases such as cancer, plants, animals, bacteria, viruses, and whole environments. With a thriving culture of ambition and strong innovation goals, Oxford Nanopore is a UK headquartered company with global operations and customers in more than 125 countries. We are looking for a Research Scientist to join the Nanopore Research Team. This exciting and challenging role will be responsible for accelerating our efforts to improve the performance of our baseline nanopores and will also contribute to the development of novel biological nanopores for an increasing range of applications, including protein sequencing. The Details The successful candidate will be responsible for the design, expression and purification, electrophysiological characterisation and the subsequent analysis of a range of nanopores. What We're Looking For The candidate will be in possession of a BSc in biochemistry, physics, biology, chemistry or equivalent. Knowledge of protein structure, membrane proteins and their expression and purification would be advantageous. Furthermore, experience of using the Linux operating system, Python based data analysis and R is highly desirable. Applications are encouraged from candidates who can adapt quickly to new challenges and enjoy working with an agile approach to research. The successful candidate will need to work meticulously to a high standard and be able to perform well under pressure to meet deadlines in a demanding and fast paced environment. We offer outstanding benefits to include an attractive bonus, generous pension contributions, private healthcare and an excellent starting salary. Based within beautiful, landscaped surroundings with tree-lined walks, water features and a lake, all of which make for a wonderful working environment. If you are looking to utilise your skills to really make a difference to humankind, then consider joining our team and apply today! Please note that no terminology in this advert is intended to discriminate on the grounds of a person's gender, marital status, race, religion, colour, age, disability or sexual orientation. Every candidate will be assessed only in accordance with their merits, qualifications and abilities to perform the duties of the job. Oxford Nanopore Technologies: Our goal is to bring the widest benefits to society through enabling the analysis of anything, by anyone, anywhere. The company has developed a new generation of nanopore-based sensing technology for faster, information rich, accessible and affordable molecular analysis. The first application is DNA/RNA sequencing, and the technology is in development for the analysis of other types of molecules including proteins. The technology is used to understand and characterise the biology of humans and diseases such as cancer, plants, animals, bacteria, viruses, and whole environments. With a thriving culture of ambition and strong innovation goals, Oxford Nanopore is a UK headquartered company with global operations and customers in more than 125 countries.

View Vacancy MRC Postdoctoral Research Scientist LMS 2662 Open Date 11/07/2025, 10:00 Close Date 12/08/2025, 23:55 Research Institute MRC Laboratory of Medical Sciences Research Institute / Unit Information The LMS is a world-class research laboratory where scientists and clinicians collaborate to advance the understanding of biology and its application to medicine. Funded by the MRC as part of UK Research and Innovation , the LMS has a collaborative working culture and new state-of-the-art building based in the heart of West London in the Hammersmith Hospital Campus (W12). The LMS aims to deliver transdisciplinary team science, in synergistic interaction with Imperial College and the wider national research environment. Part of achieving this, is to recruit new talent and support postdoctoral scientists to become world leaders in their area of science. UK Research and Innovation is a new entity that brings together nine partners to create an independent organisation with a strong voice for research and innovation, more information can be found at Band MRC - 4 Location London £41,344 plus London allowances £5,385 per annum Additional allowances comprise a £1,000 lump sum Settlement Allowance plus a yearly Training Allowance of £850 in the first year, paid in monthly instalments. The Training Allowance increases to £1,300 in year two Contract Type Fixed Term Job Type Science Full Time / Part Time Full Time 2 years (with a possibility of extension) Job Description Overall purpose: Research Programme The Reprogramming and Chromatin group led by Prof Petra Hajkova investigates molecular processes that underlie global erasure of epigenetic information. As in vitro cellular reprogramming systems are notoriously inefficient and heterogeneous in outcome, we focus on the epigenetic reprogramming events that occur naturally in vivo during mouse development (in the mouse zygote and in the developing mouse germ cells) ( ). We have a particular interest in deciphering the mechanisms underlying the waves of global DNA demethylation (Amouroux et al, 2016, Hill et al, Nature 2018; Huang et al, Nature 2021) and the changes in chromatin structure that accompanies this process. Purpose of Post The focus of this project is to investigate molecular mechanisms underpinning zygotic and germline DNA demethylation, the mechanistic links to DNA repair and the functional relationship to the progression through the germline cycle. The ideal candidate will be expected to carry out research within the focus area of the Reprogramming and Chromatin Group; undertake project management and be involved in the supervision of PhD students in the laboratory. In addition, he/she will be expected to submit publications to refereed journals and to attract external research funding. Main duties / key responsibilities: To take initiatives in the planning of research To direct the work of small research teams To identify and develop suitable techniques, and apparatus, for the collection and analysis of data To conduct data analysis To ensure the validity and reliability of data at all times To maintain accurate and complete records of all findings To write reports for submission to research sponsors To present findings to colleagues and at conferences To submit publications to refereed journals To provide guidance to staff and students To attend relevant workshops and conferences as necessary To develop contacts and research collaborations within the College and the wider community To promote the reputation of the Group, the Department and the Institute To provide guidance to PhD Students Contribute to bids for research grants To conduct and plan own scientific work with appropriate supervision To maintain highly organised and accurate record of experimental work To actively participate in the research programme of the Group and Unit To publish in high quality journals and to present data at national and international meetings To participate in Group/Unit research meetings and internal seminars Willingness to work out of normal working hours (including weekends) if the requirements of the project demand To collaborate with other allied scientists within Institute and elsewhere in London and abroad, as appropriate To contribute to the smooth running of the Group's/Unit's laboratories and, facilities with other scientists, clinicians, technicians and students within the laboratories To assist in the supervision of undergraduate and postgraduate research students and research assistants as required To comply with the Institute safety practices and to attend courses on safety when appropriate Any other duties as may be deemed reasonable by Head of group Working relationships: The post-holder will report directly to the head of the group, Professor Petra Hajkova. Additional information: This post is an MRC Postdoctoral Scientist to support post-doctoral training and help establish successful research scientists in their chosen field. During the fellowship tenure we are committed to provide mentorship for career development and improvement of communication skills. Person Specification Education / Qualifications / Training required (will be assessed from the application): Essential: PhD degree (or equivalent experience) in a biological or related discipline Desirable: UK Home Office personal licence (PIL) for work with rodents Previous work experience required (will be assessed from the application and at the interview): Essential: Proven experience in the field of epigenetics and chromatin Experience with isolation, manipulation and culture of mouse oocytes and early mouse preimplantation embryos Extensive experience with cell lines and mouse primary cell culture techniques Experience with culture of mouse pluripotent stem cells Knowledge of relevant biochemical and molecular biology research methods and statistical procedures Good written communication skills in English Desirable: Experience with derivation of mouse embryonic stem cells Experience with NGS approaches to investigate epigenome Personal skills / Behaviours / Qualities (will be assessed at the interview): Essential: Evidence of organisational ability Good verbal communication skills in English and the ability to work effectively with researchers ranging from postgraduate students to professorial level Ability to work both independently and as part of a team IT literate and familiar with basic methods for sequence and image analysis Desirable: A highly committed individual with proactive and flexible attitude to work The ability and willingness to learn new concepts and technologies rapidly The ability to work under pressure in the competitive field Further Information Pleaseupload your CV, the names and contact details of two scientific references along with a covering letter stating why you are applying for this role (providing evidence against the requirements of the job as per the job description and person specification). Applications without a cover letter will not be considered. Please quote reference number LMS 2662. This role qualifies for endorsement by UKRI for a UK Global Talent Visa, for which the successfulapplicant is likely to be eligible to apply. Immigrationcosts for the applicant (100% visa and 100% Health Surcharge) and immediate dependents (100% visa and 50% health surcharge when applying with the main applicant) can be reclaimed from LMS after taking up the post (terms and conditions apply). Please note that applications may be reviewed by both LMS and Imperial staff The MRC is a unique working environment where scientific researchers and professional support staff can actively partake in world class innovation and collaboration opportunities and their skills and knowledge through accessing a wide catalogue of training & development, including professional registration with the Science Council. In addition, MRC (part of UKRI) provides its community of employees access to a whole host of useful benefits, including a defined benefit pension scheme and excellent holiday entitlement (30 days plus 2.5 privilege days & 8 bank holidays), family friendly policies (6 months full pay maternity & adoption leave), a range of shopping/travel discounts, access to our Employee Assistant Programme Scheme, Health and Wellbeing Support and a salary sacrifice cycle to work scheme. Please follow this link to find out more - Benefits Our success is dependent upon our ability to embrace diversity and draw on the skills, understanding and experience of all our people. We warmly invite people from diverse backgrounds and heritage, including people who identify as having a disability, to apply for a role that excites them. As "Disability Confident" employers, we guarantee to interview all applicants who have disclosed they have a disability and who meet the minimum criteria for the vacancy. . click apply for full job details