What if you could join an organization that creates, resources, and builds life sciences companies that invent breakthrough technologies to transform human health and sustainability? Company Summary: Quotient Therapeutics, Inc. is a privately held, early-stage company developing a novel genomics platform and therapeutics for diseases with a large unmet need. Quotient Therapeutics, Inc. was founded by Flagship Pioneering, an innovative enterprise that conceives, creates, resources, and grows first-in-category life sciences companies. Flagship Pioneering has created over 100 groundbreaking companies over the past twenty years, all of which are pioneering novel and proprietary biological, industrial, and engineering approaches to solve major needs in human health and sustainability. These companies include Moderna (MRNA), Generate Biomedicines, Sana Biotechnology (SANA), Tessera Therapeutics, Evelo Biosciences (EVLO), Indigo Agriculture, Seres Therapeutics (MCRB), and Syros Pharmaceuticals (SYRS). To date, Flagship has deployed over $2.5 billion in capital toward the founding and growth of its pioneering companies alongside more than $19 billion of follow-on investments from other institutions. In 2021, Flagship Pioneering was ranked 12th globally on Fortune's "Change the World" list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies. Position Summary: We are seeking a visionary Senior AI/ML Scientist to be part of ground-breaking research at the forefront of somatic genomics . You will be part of a dynamic team at Quotient's multidisciplinary research environment comprising AI scientists, computational biologists, genome scientists, software engineers, and disease area specialists. You will also work closely with specialists in translational science, drug discovery, and pre-clinical modelling. In this role, you will be responsible for designing and implementing novel machine learning and deep learning methods applied to somatic genomics. This includes identifying research problems that could be addressed through structured or unstructured, complex omics and imaging data and developing appropriate models and analytical solutions. Responsibilities: Develop and implement novel machine learning and deep learning methods to address key challenges in somatic genomics, ranging from imaging data analysis to variant interpretation. Extract research and business value from complex, unstructured somatic genomics data and metadata. Optimize large-scale data preparation, enhance analytics platforms, and industrialize validated analytical methods in collaboration with the data engineering team. Uncover novel biological insights into disease, spanning complex and rare diseases, and develop methods to validate new drug targets. Evaluate the scientific and technical integrity of algorithms and tools within the analysis pipeline. Work closely with discovery and development teams to integrate genomic and histology imaging analysis. Communicate findings effectively to both technical and non-technical audiences. Key Qualifications: PhD (or equivalent experience) in Machine Learning, Computational Biology, Bioinformatics, or a related quantitative field. Strong programming skills with a solid understanding of algorithms and data structures. Proficiency in Python with hands-on experience using open-source ML frameworks such as scikit-learn, PyTorch, TensorFlow, or Keras. Extensive experience with Machine Learning and Deep Learning models (e.g., tree-based methods, CNNs, Transformers) and developing robust, production-ready ML systems. Strong communication skills, with the ability to convey complex ideas to both experts and non-experts through discussion and clear documentation. Excellent problem-solving and prioritization skills, with a collaborative mindset suited to a fast-paced, evolving environment. Passion for applying machine learning to life sciences, with an understanding of genomics and its impact on drug discovery. Additional Preferred Skills: Experience with AI Vision techniques (e.g., image segmentation, classification). Familiarity with Generative AI (LLMs). Experience with large-scale multi-omics data analysis. Hands-on experience with cloud computing (AWS). Location: Cambridge, England At Quotient Therapeutics, we're not just a team; we're pioneers on a mission to revolutionise the biotech landscape. Nestled in the vibrant outskirts of Cambridge, our company is all about innovative thinking and collaborative spirit. What We Offer: A Crucible of Innovation : Dive into a world where your ideas matter. Our work environment is dynamic, encouraging creativity and out-of-the-box thinking. Here, every voice contributes to our groundbreaking solutions. Professional Growth in a Supportive Environment : While we're small, our aspirations are big. You'll have the unique opportunity to grow with us, learning new skills and tackling diverse challenges every day. Your growth is our growth. Competitive Compensation : We understand the value of our team. That's why we offer competitive salaries that match your expertise and contribution to our shared goals. Above Standard Facilities : Our labs and workspaces are more than just functional. Enjoy working in above-standard facilities that stand out in the start-up world, fostering both comfort and innovation. Located at the Heart of Biotech Innovation : Our location isn't just a place; it's a strategic advantage. Situated near Cambridge, you'll be at the crossroads of biotech innovation and a thriving, intellectually stimulating community. Making a Difference : Here, your work transcends the ordinary. We're about making a tangible, positive impact on the world through our biotech advancements. Equality, Diversity, and Inclusion Aware : We're committed to creating a workplace where everyone feels valued and respected. While our formal ED&I statement is still in the works, we're actively aware and integrating these principles into our daily operations. While we are still growing and enhancing our benefits package, we believe that the opportunity to be a part of a transformative team in a rapidly evolving industry is a rewarding experience in itself. If you're ready to make a significant impact and grow with us, we'd love to hear from you. Flagship Pioneering and our ecosystem companies are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.
Jul 16, 2025
Full time
What if you could join an organization that creates, resources, and builds life sciences companies that invent breakthrough technologies to transform human health and sustainability? Company Summary: Quotient Therapeutics, Inc. is a privately held, early-stage company developing a novel genomics platform and therapeutics for diseases with a large unmet need. Quotient Therapeutics, Inc. was founded by Flagship Pioneering, an innovative enterprise that conceives, creates, resources, and grows first-in-category life sciences companies. Flagship Pioneering has created over 100 groundbreaking companies over the past twenty years, all of which are pioneering novel and proprietary biological, industrial, and engineering approaches to solve major needs in human health and sustainability. These companies include Moderna (MRNA), Generate Biomedicines, Sana Biotechnology (SANA), Tessera Therapeutics, Evelo Biosciences (EVLO), Indigo Agriculture, Seres Therapeutics (MCRB), and Syros Pharmaceuticals (SYRS). To date, Flagship has deployed over $2.5 billion in capital toward the founding and growth of its pioneering companies alongside more than $19 billion of follow-on investments from other institutions. In 2021, Flagship Pioneering was ranked 12th globally on Fortune's "Change the World" list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies. Position Summary: We are seeking a visionary Senior AI/ML Scientist to be part of ground-breaking research at the forefront of somatic genomics . You will be part of a dynamic team at Quotient's multidisciplinary research environment comprising AI scientists, computational biologists, genome scientists, software engineers, and disease area specialists. You will also work closely with specialists in translational science, drug discovery, and pre-clinical modelling. In this role, you will be responsible for designing and implementing novel machine learning and deep learning methods applied to somatic genomics. This includes identifying research problems that could be addressed through structured or unstructured, complex omics and imaging data and developing appropriate models and analytical solutions. Responsibilities: Develop and implement novel machine learning and deep learning methods to address key challenges in somatic genomics, ranging from imaging data analysis to variant interpretation. Extract research and business value from complex, unstructured somatic genomics data and metadata. Optimize large-scale data preparation, enhance analytics platforms, and industrialize validated analytical methods in collaboration with the data engineering team. Uncover novel biological insights into disease, spanning complex and rare diseases, and develop methods to validate new drug targets. Evaluate the scientific and technical integrity of algorithms and tools within the analysis pipeline. Work closely with discovery and development teams to integrate genomic and histology imaging analysis. Communicate findings effectively to both technical and non-technical audiences. Key Qualifications: PhD (or equivalent experience) in Machine Learning, Computational Biology, Bioinformatics, or a related quantitative field. Strong programming skills with a solid understanding of algorithms and data structures. Proficiency in Python with hands-on experience using open-source ML frameworks such as scikit-learn, PyTorch, TensorFlow, or Keras. Extensive experience with Machine Learning and Deep Learning models (e.g., tree-based methods, CNNs, Transformers) and developing robust, production-ready ML systems. Strong communication skills, with the ability to convey complex ideas to both experts and non-experts through discussion and clear documentation. Excellent problem-solving and prioritization skills, with a collaborative mindset suited to a fast-paced, evolving environment. Passion for applying machine learning to life sciences, with an understanding of genomics and its impact on drug discovery. Additional Preferred Skills: Experience with AI Vision techniques (e.g., image segmentation, classification). Familiarity with Generative AI (LLMs). Experience with large-scale multi-omics data analysis. Hands-on experience with cloud computing (AWS). Location: Cambridge, England At Quotient Therapeutics, we're not just a team; we're pioneers on a mission to revolutionise the biotech landscape. Nestled in the vibrant outskirts of Cambridge, our company is all about innovative thinking and collaborative spirit. What We Offer: A Crucible of Innovation : Dive into a world where your ideas matter. Our work environment is dynamic, encouraging creativity and out-of-the-box thinking. Here, every voice contributes to our groundbreaking solutions. Professional Growth in a Supportive Environment : While we're small, our aspirations are big. You'll have the unique opportunity to grow with us, learning new skills and tackling diverse challenges every day. Your growth is our growth. Competitive Compensation : We understand the value of our team. That's why we offer competitive salaries that match your expertise and contribution to our shared goals. Above Standard Facilities : Our labs and workspaces are more than just functional. Enjoy working in above-standard facilities that stand out in the start-up world, fostering both comfort and innovation. Located at the Heart of Biotech Innovation : Our location isn't just a place; it's a strategic advantage. Situated near Cambridge, you'll be at the crossroads of biotech innovation and a thriving, intellectually stimulating community. Making a Difference : Here, your work transcends the ordinary. We're about making a tangible, positive impact on the world through our biotech advancements. Equality, Diversity, and Inclusion Aware : We're committed to creating a workplace where everyone feels valued and respected. While our formal ED&I statement is still in the works, we're actively aware and integrating these principles into our daily operations. While we are still growing and enhancing our benefits package, we believe that the opportunity to be a part of a transformative team in a rapidly evolving industry is a rewarding experience in itself. If you're ready to make a significant impact and grow with us, we'd love to hear from you. Flagship Pioneering and our ecosystem companies are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.
Ellison Institute of Technology
Oxford, Oxfordshire
The Ellison Institute of Technology (EIT) Oxford tackles humanity's greatest challenges by turning science and technology into impactful global solutions. Focused on areas like health, food security, sustainable agriculture, climate change, clean energy, and AI-driven government innovation, EIT Oxford blends groundbreaking research with practical applications to deliver lasting results. A cornerstone of EIT Oxford's mission is its upcoming 300,000-square-foot research facility at the Oxford Science Park, set to open in 2027. This cutting-edge campus will feature advanced labs, an oncology and preventative care clinic, and collaborative spaces to strengthen its partnership with the University of Oxford. It will also host the Ellison Scholars, driving innovation for societal benefit. The Pathogen Mission highlights EIT's transformative approach, using Whole Genome Sequencing (WGS) and Oracle's cloud technology to create a global pathogen metagenomics system. This initiative aims to improve diagnostics, provide early epidemic warnings, and guide treatments by profiling antimicrobial resistance. The goal is to deliver certified diagnostic tools for widespread use in labs, hospitals, and public health. EIT Oxford fosters a culture of collaboration, innovation, and resilience, valuing diverse expertise to drive sustainable solutions to humanity's enduring challenges. We are seeking a Senior Scientist, Microfluidics to support the research and product development of EIT Oxford's Pathogen Programme. The lab-based role involves designing, fabricating and testing microfluidic flow cells for the extraction of DNA and other relevant biological substances from microbial pathogens (bacteria, viruses, fungi and other eukaryotes) from clinical and other sources to inform the diagnosis and treatment of infectious disease in humans. The role will involve working with other scientists and engineers in small teams to deliver the project milestones. The postholder includes prototyping fluidic array structures for the movement of small fluid volumes between reaction and purification chambers, fabrication of these arrays for evaluation purposes, designing and performing tests to evaluate the performance of the microfluidic array for DNA extraction and manipulation. Ideal candidates will have expertise in microfluidics, MEMs fabrication, analytical chemistry, and assay development. Experience working with biological samples and DNA would be beneficial. Key Responsibilities: Research, development, and optimisation of microfluidic systems for DNA extraction from biosamples, and the subsequent purification and DNA manipulation. Design and execute experiments for device characterisation, fluid dynamics analysis, and performance validation. Develop and run protocols for fabrication, assembly, and testing of microfluidic devices. Optimise the array and flow cell performance for high yields, greater ease of use and robustness. Contribute to intellectual property generation, including patents and technical disclosures. Prepare technical documentation, reports, and presentations for internal stakeholders and external collaborators. Qualifications & Experience: 2+ years industry experience and PhD or equivalent experience in Engineering, Physics, Bioengineering, or related field with specialisation in microfluidics, MEMS, or lab-on-a-chip systems. Hands-on experience with microfabrication techniques such as soft lithography, photolithography, CNC micromilling, injection moulding, or 3D microprinting. Proven ability to design and execute experiments to characterise microfluidic systems (e.g., flow profiling, pressure measurements, mixing efficiency, droplet generation). Skilled in integrating microfluidics with sensors, optics, electronics, or automation platforms. Desirable Knowledge, Skills and Experience: Familiarity with biological or biochemical applications in microfluidics (e.g., single-cell analysis, droplet microfluidics, bead handling, point-of-care diagnostics, organ-on-chip). Experience in troubleshooting and optimizing fluidic workflows in complex systems. Familiarity with microscopy and imaging techniques relevant to microfluidics (e.g., fluorescence, brightfield, confocal). Experience of developing technologies within regulatory frameworks for in vitro diagnostics within the UK, EU or USA. We offer the following salary and benefits: Salary: Competitive salary on offer Enhanced holiday pay Pension Life Assurance Income Protection Private Medical Insurance Hospital Cash Plan Therapy Services Perk Box Electrical Car Scheme Why work for EIT: At the Ellison Institute, we believe a collaborative, inclusive team is key to our success. We are building a supportive environment where creative risks are encouraged, and everyone feels heard. Valuing emotional intelligence, empathy, respect, and resilience, we encourage people to be curious and to have a shared commitment to excellence. Join us and make an impact! Terms of Appointment: You must have the right to work permanently in the UK with a willingness to travel as necessary. You will live in, or within easy commuting distance of, Oxford. During peak periods, some longer hours may be required and some working across multiple time zones due to the global nature of the programme.
Jul 16, 2025
Full time
The Ellison Institute of Technology (EIT) Oxford tackles humanity's greatest challenges by turning science and technology into impactful global solutions. Focused on areas like health, food security, sustainable agriculture, climate change, clean energy, and AI-driven government innovation, EIT Oxford blends groundbreaking research with practical applications to deliver lasting results. A cornerstone of EIT Oxford's mission is its upcoming 300,000-square-foot research facility at the Oxford Science Park, set to open in 2027. This cutting-edge campus will feature advanced labs, an oncology and preventative care clinic, and collaborative spaces to strengthen its partnership with the University of Oxford. It will also host the Ellison Scholars, driving innovation for societal benefit. The Pathogen Mission highlights EIT's transformative approach, using Whole Genome Sequencing (WGS) and Oracle's cloud technology to create a global pathogen metagenomics system. This initiative aims to improve diagnostics, provide early epidemic warnings, and guide treatments by profiling antimicrobial resistance. The goal is to deliver certified diagnostic tools for widespread use in labs, hospitals, and public health. EIT Oxford fosters a culture of collaboration, innovation, and resilience, valuing diverse expertise to drive sustainable solutions to humanity's enduring challenges. We are seeking a Senior Scientist, Microfluidics to support the research and product development of EIT Oxford's Pathogen Programme. The lab-based role involves designing, fabricating and testing microfluidic flow cells for the extraction of DNA and other relevant biological substances from microbial pathogens (bacteria, viruses, fungi and other eukaryotes) from clinical and other sources to inform the diagnosis and treatment of infectious disease in humans. The role will involve working with other scientists and engineers in small teams to deliver the project milestones. The postholder includes prototyping fluidic array structures for the movement of small fluid volumes between reaction and purification chambers, fabrication of these arrays for evaluation purposes, designing and performing tests to evaluate the performance of the microfluidic array for DNA extraction and manipulation. Ideal candidates will have expertise in microfluidics, MEMs fabrication, analytical chemistry, and assay development. Experience working with biological samples and DNA would be beneficial. Key Responsibilities: Research, development, and optimisation of microfluidic systems for DNA extraction from biosamples, and the subsequent purification and DNA manipulation. Design and execute experiments for device characterisation, fluid dynamics analysis, and performance validation. Develop and run protocols for fabrication, assembly, and testing of microfluidic devices. Optimise the array and flow cell performance for high yields, greater ease of use and robustness. Contribute to intellectual property generation, including patents and technical disclosures. Prepare technical documentation, reports, and presentations for internal stakeholders and external collaborators. Qualifications & Experience: 2+ years industry experience and PhD or equivalent experience in Engineering, Physics, Bioengineering, or related field with specialisation in microfluidics, MEMS, or lab-on-a-chip systems. Hands-on experience with microfabrication techniques such as soft lithography, photolithography, CNC micromilling, injection moulding, or 3D microprinting. Proven ability to design and execute experiments to characterise microfluidic systems (e.g., flow profiling, pressure measurements, mixing efficiency, droplet generation). Skilled in integrating microfluidics with sensors, optics, electronics, or automation platforms. Desirable Knowledge, Skills and Experience: Familiarity with biological or biochemical applications in microfluidics (e.g., single-cell analysis, droplet microfluidics, bead handling, point-of-care diagnostics, organ-on-chip). Experience in troubleshooting and optimizing fluidic workflows in complex systems. Familiarity with microscopy and imaging techniques relevant to microfluidics (e.g., fluorescence, brightfield, confocal). Experience of developing technologies within regulatory frameworks for in vitro diagnostics within the UK, EU or USA. We offer the following salary and benefits: Salary: Competitive salary on offer Enhanced holiday pay Pension Life Assurance Income Protection Private Medical Insurance Hospital Cash Plan Therapy Services Perk Box Electrical Car Scheme Why work for EIT: At the Ellison Institute, we believe a collaborative, inclusive team is key to our success. We are building a supportive environment where creative risks are encouraged, and everyone feels heard. Valuing emotional intelligence, empathy, respect, and resilience, we encourage people to be curious and to have a shared commitment to excellence. Join us and make an impact! Terms of Appointment: You must have the right to work permanently in the UK with a willingness to travel as necessary. You will live in, or within easy commuting distance of, Oxford. During peak periods, some longer hours may be required and some working across multiple time zones due to the global nature of the programme.
Enara Bio's purpose is to shine a light on unconventional T cell targets to develop cancer immunotherapies designed to provide lasting benefit for broad patient populations. Our proprietary EDAPT platform enables us to discover a novel and differentiated class of cancer-specific targets from the genomic dark matter, which we call Dark Antigens. We are pioneering approaches to exploit these Dark Antigen targets with a range of immunotherapeutic modalities, including bispecific T-cell engagers, adoptive cell therapies and cancer vaccines. Enara Bio was founded in 2016 and has been well funded to invest in the build out and growth of our R&D efforts and our fantastic team. The company is based in Oxford, UK. Role Overview A temporary full-time role has opened in the Cell and Immunobiology function at Enara Bio to assist for a period of six months. We are looking for a Scientist or Senior Scientist who has a deep passion for immunology and the role of T-cells in the exciting field of immuno-oncology. We want you to help to build an understanding of human T-cell biology against Enara Bio's novel tumour-specific antigens and translate this understanding into transformative products that enhance the anti-tumour T cell response in the tumour microenvironment. This is an opportunity for an innovative scientist to discover and develop an early stage product through to clinical application. The candidate will be expected to play an active role in performing Lab-based Immunobiology assays in addition to helping in preparation for upcoming projects in lab and non-lab roles. Due to the short-term nature of this fixed-term contract, we are unfortunately unable to offer visa sponsorship. Applicants must have the existing right to work in the UK for the duration of the contract. Role Requirements You will be responsible for: Actively contributing to a vibrant and innovative working environment where improvements and new ideas are adopted and freely shared among the teams Senior Scientist- Providing scientific coaching and mentorship for less experienced scientists in the team, as well as other scientists in our matrixed environment Senior Scientist- Providing expert technical direction, challenge and problem solving in projects Working closely with other research functional teams (e.g. Bioinformatics and Immunopeptidomics) to validate the role of novel T cell antigens and cognate T cell receptors in cancer Designing, conducting and evaluating experiments to establish the efficacy of T cell receptors against novel cancer antigens T cell profiling for very low frequency cells (use of ELISpot, multimers), FACS sorting/analysis, CTL cloning and recombinant T cell receptor expression/characterization. Killing assays using impedence-based and imaging methodology Qualifications and Experience required Scientist Proven experience of working with CAR-T/TCR-T or T cell engager methodologies ideally in a biotech setting or alternatively in an academic setting Proven experience of working on cell or protein-based therapies Proven experience of relevant Immunological laboratory techniques Senior Scientist Proven experience of working with CAR-T/TCR-T or T cell engager methodologies ideally in a biotech setting or alternatively in an academic setting Proven experience of working on cell or protein-based therapies A PhD in a relevant scientific discipline, strong expertise in immunology preferred, or demonstrable industry experience Proven experience of relevant Immunological laboratory techniques Previous proven experience of mentoring other scientists Further information: The Enara Bio team is driven to make a meaningful difference for people affected by cancer. Our culture is defined by our behavioural ethos: Empowerment: We promote autonomy across Enara rejecting conventional hierarchy. We engage each other through transparency, collaboration and trust. We each take action with a deep sense of personal and shared accountability. Courage: We push boundaries in all that we do to deliver on our purpose. We make bold decisions, embrace risk and tackle challenges to advance our novel science. Courage is essential for everything we do. Humility: We are proud of and excited by our novel science, but we acknowledge that we cannot know everything. Our curiosity drives us to continually learn from each other & the outside world irrespective of our role or title. We give and receive feedback with no room for ego. Growth: We invest in our people, culture and community to foster belonging as a foundation for success. We embrace individual development to create deeper personal fulfilment and drive stronger collective impact. We offer a competitive salary, commensurate with qualifications and experience, and a benefits package including pension and health insurance. Enara Bio Limited is an equal opportunities employer.
Jul 16, 2025
Full time
Enara Bio's purpose is to shine a light on unconventional T cell targets to develop cancer immunotherapies designed to provide lasting benefit for broad patient populations. Our proprietary EDAPT platform enables us to discover a novel and differentiated class of cancer-specific targets from the genomic dark matter, which we call Dark Antigens. We are pioneering approaches to exploit these Dark Antigen targets with a range of immunotherapeutic modalities, including bispecific T-cell engagers, adoptive cell therapies and cancer vaccines. Enara Bio was founded in 2016 and has been well funded to invest in the build out and growth of our R&D efforts and our fantastic team. The company is based in Oxford, UK. Role Overview A temporary full-time role has opened in the Cell and Immunobiology function at Enara Bio to assist for a period of six months. We are looking for a Scientist or Senior Scientist who has a deep passion for immunology and the role of T-cells in the exciting field of immuno-oncology. We want you to help to build an understanding of human T-cell biology against Enara Bio's novel tumour-specific antigens and translate this understanding into transformative products that enhance the anti-tumour T cell response in the tumour microenvironment. This is an opportunity for an innovative scientist to discover and develop an early stage product through to clinical application. The candidate will be expected to play an active role in performing Lab-based Immunobiology assays in addition to helping in preparation for upcoming projects in lab and non-lab roles. Due to the short-term nature of this fixed-term contract, we are unfortunately unable to offer visa sponsorship. Applicants must have the existing right to work in the UK for the duration of the contract. Role Requirements You will be responsible for: Actively contributing to a vibrant and innovative working environment where improvements and new ideas are adopted and freely shared among the teams Senior Scientist- Providing scientific coaching and mentorship for less experienced scientists in the team, as well as other scientists in our matrixed environment Senior Scientist- Providing expert technical direction, challenge and problem solving in projects Working closely with other research functional teams (e.g. Bioinformatics and Immunopeptidomics) to validate the role of novel T cell antigens and cognate T cell receptors in cancer Designing, conducting and evaluating experiments to establish the efficacy of T cell receptors against novel cancer antigens T cell profiling for very low frequency cells (use of ELISpot, multimers), FACS sorting/analysis, CTL cloning and recombinant T cell receptor expression/characterization. Killing assays using impedence-based and imaging methodology Qualifications and Experience required Scientist Proven experience of working with CAR-T/TCR-T or T cell engager methodologies ideally in a biotech setting or alternatively in an academic setting Proven experience of working on cell or protein-based therapies Proven experience of relevant Immunological laboratory techniques Senior Scientist Proven experience of working with CAR-T/TCR-T or T cell engager methodologies ideally in a biotech setting or alternatively in an academic setting Proven experience of working on cell or protein-based therapies A PhD in a relevant scientific discipline, strong expertise in immunology preferred, or demonstrable industry experience Proven experience of relevant Immunological laboratory techniques Previous proven experience of mentoring other scientists Further information: The Enara Bio team is driven to make a meaningful difference for people affected by cancer. Our culture is defined by our behavioural ethos: Empowerment: We promote autonomy across Enara rejecting conventional hierarchy. We engage each other through transparency, collaboration and trust. We each take action with a deep sense of personal and shared accountability. Courage: We push boundaries in all that we do to deliver on our purpose. We make bold decisions, embrace risk and tackle challenges to advance our novel science. Courage is essential for everything we do. Humility: We are proud of and excited by our novel science, but we acknowledge that we cannot know everything. Our curiosity drives us to continually learn from each other & the outside world irrespective of our role or title. We give and receive feedback with no room for ego. Growth: We invest in our people, culture and community to foster belonging as a foundation for success. We embrace individual development to create deeper personal fulfilment and drive stronger collective impact. We offer a competitive salary, commensurate with qualifications and experience, and a benefits package including pension and health insurance. Enara Bio Limited is an equal opportunities employer.
The Ellison Institute of Technology (EIT) Oxford tackles humanity's greatest challenges by turning science and technology into impactful global solutions. Focused on areas like health, food security, sustainable agriculture, climate change, clean energy, and AI-driven government innovation, EIT Oxford blends groundbreaking research with practical applications to deliver lasting results. A cornerstone of EIT Oxford's mission is its upcoming 300,000-square-foot research facility at the Oxford Science Park, set to open in 2027. This cutting-edge campus will feature advanced labs, an oncology and preventative care clinic, and collaborative spaces to strengthen its partnership with the University of Oxford. It will also host the Ellison Scholars, driving innovation for societal benefit. The Pathogen Mission highlights EIT's transformative approach, using Whole Genome Sequencing (WGS) and Oracle's cloud technology to create a global pathogen metagenomics system. This initiative aims to improve diagnostics, provide early epidemic warnings, and guide treatments by profiling antimicrobial resistance. The goal is to deliver certified diagnostic tools for widespread use in labs, hospitals, and public health. EIT Oxford fosters a culture of collaboration, innovation, and resilience, valuing diverse expertise to drive sustainable solutions to humanity's enduring challenges. We are seeking a Senior Scientist, Microfluidics to support the research and product development of EIT Oxford's Pathogen Programme. The lab-based role involves designing, fabricating and testing microfluidic flow cells for the extraction of DNA and other relevant biological substances from microbial pathogens (bacteria, viruses, fungi and other eukaryotes) from clinical and other sources to inform the diagnosis and treatment of infectious disease in humans. The role will involves working with other scientists and engineers in small teams to deliver the project milestones. The postholder includes prototyping fluidic array structures for the movement of small fluid volumes between reaction and purification chambers, fabrication of these arrays for evaluation purposes, designing and performing tests to evaluate the performance of the microfluidic array for DNA extraction and manipulation. Ideal candidates will have expertise in microfluidics, MEMs fabrication, analytical chemistry, assay development. Experience working with biological sample and DNA would be beneficial. Key Responsibilities: Research, development, and optimisation of microfluidic systems for DNA extraction from biosamples, and the subsequent purification and DNA manipulation. Design and execute experiments for device characterisation, fluid dynamics analysis, and performance validation. Develop and run protocols for fabrication, assembly, and testing of microfluidic devices. Optimise the array and flow cell performance for high yields, greater ease of use and robustness. Contribute to intellectual property generation, including patents and technical disclosures. Prepare technical documentation, reports, and presentations for internal stakeholders and external collaborators. Qualifications & Experience: 2+ years industry experience and PhD or equivalent experience in Engineering, Physics, Bioengineering, or related field with specialisation in microfluidics, MEMS, or lab-on-a-chip systems Hands-on experience with microfabrication techniques such as soft lithography, photolithography, CNC micromilling, injection moulding, or 3D microprinting. Proven ability to design and execute experiments to characterise microfluidic systems (e.g., flow profiling, pressure measurements, mixing efficiency, droplet generation). Skilled in integrating microfluidics with sensors, optics, electronics, or automation platforms. Desirable Knowledge, Skills and Experience: Familiarity with biological or biochemical applications in microfluidics (e.g., single-cell analysis, droplet microfluidics, bead handling, point-of-care diagnostics, organ-on-chip). Experience in troubleshooting and optimizing fluidic workflows in complex systems. Familiarity with microscopy and imaging techniques relevant to microfluidics (e.g., fluorescence, brightfield, confocal). Experience of developing technologies within regulatory frameworks for in vitro diagnostics within the UK, EU or USA. We offer the following salary and benefits: Salary: Competitive salary on offer Enhanced holiday pay Pension Life Assurance Income Protection Private Medical Insurance Hospital Cash Plan Therapy Services Perk Box Electrical Car Scheme Why work for EIT: At the Ellison Institute, we believe a collaborative, inclusive team is key to our success. We are building a supportive environment where creative risks are encouraged, and everyone feels heard. Valuing emotional intelligence, empathy, respect, and resilience, we encourage people to be curious and to have a shared commitment to excellence. Join us and make an impact! Terms of Appointment: You must have the right to work permanently in the UK with a willingness to travel as necessary. You will live in, or within easy commuting distance of, Oxford. During peak periods, some longer hours may be required and some working across multiple time zones due to the global nature of the programme.
Jul 16, 2025
Full time
The Ellison Institute of Technology (EIT) Oxford tackles humanity's greatest challenges by turning science and technology into impactful global solutions. Focused on areas like health, food security, sustainable agriculture, climate change, clean energy, and AI-driven government innovation, EIT Oxford blends groundbreaking research with practical applications to deliver lasting results. A cornerstone of EIT Oxford's mission is its upcoming 300,000-square-foot research facility at the Oxford Science Park, set to open in 2027. This cutting-edge campus will feature advanced labs, an oncology and preventative care clinic, and collaborative spaces to strengthen its partnership with the University of Oxford. It will also host the Ellison Scholars, driving innovation for societal benefit. The Pathogen Mission highlights EIT's transformative approach, using Whole Genome Sequencing (WGS) and Oracle's cloud technology to create a global pathogen metagenomics system. This initiative aims to improve diagnostics, provide early epidemic warnings, and guide treatments by profiling antimicrobial resistance. The goal is to deliver certified diagnostic tools for widespread use in labs, hospitals, and public health. EIT Oxford fosters a culture of collaboration, innovation, and resilience, valuing diverse expertise to drive sustainable solutions to humanity's enduring challenges. We are seeking a Senior Scientist, Microfluidics to support the research and product development of EIT Oxford's Pathogen Programme. The lab-based role involves designing, fabricating and testing microfluidic flow cells for the extraction of DNA and other relevant biological substances from microbial pathogens (bacteria, viruses, fungi and other eukaryotes) from clinical and other sources to inform the diagnosis and treatment of infectious disease in humans. The role will involves working with other scientists and engineers in small teams to deliver the project milestones. The postholder includes prototyping fluidic array structures for the movement of small fluid volumes between reaction and purification chambers, fabrication of these arrays for evaluation purposes, designing and performing tests to evaluate the performance of the microfluidic array for DNA extraction and manipulation. Ideal candidates will have expertise in microfluidics, MEMs fabrication, analytical chemistry, assay development. Experience working with biological sample and DNA would be beneficial. Key Responsibilities: Research, development, and optimisation of microfluidic systems for DNA extraction from biosamples, and the subsequent purification and DNA manipulation. Design and execute experiments for device characterisation, fluid dynamics analysis, and performance validation. Develop and run protocols for fabrication, assembly, and testing of microfluidic devices. Optimise the array and flow cell performance for high yields, greater ease of use and robustness. Contribute to intellectual property generation, including patents and technical disclosures. Prepare technical documentation, reports, and presentations for internal stakeholders and external collaborators. Qualifications & Experience: 2+ years industry experience and PhD or equivalent experience in Engineering, Physics, Bioengineering, or related field with specialisation in microfluidics, MEMS, or lab-on-a-chip systems Hands-on experience with microfabrication techniques such as soft lithography, photolithography, CNC micromilling, injection moulding, or 3D microprinting. Proven ability to design and execute experiments to characterise microfluidic systems (e.g., flow profiling, pressure measurements, mixing efficiency, droplet generation). Skilled in integrating microfluidics with sensors, optics, electronics, or automation platforms. Desirable Knowledge, Skills and Experience: Familiarity with biological or biochemical applications in microfluidics (e.g., single-cell analysis, droplet microfluidics, bead handling, point-of-care diagnostics, organ-on-chip). Experience in troubleshooting and optimizing fluidic workflows in complex systems. Familiarity with microscopy and imaging techniques relevant to microfluidics (e.g., fluorescence, brightfield, confocal). Experience of developing technologies within regulatory frameworks for in vitro diagnostics within the UK, EU or USA. We offer the following salary and benefits: Salary: Competitive salary on offer Enhanced holiday pay Pension Life Assurance Income Protection Private Medical Insurance Hospital Cash Plan Therapy Services Perk Box Electrical Car Scheme Why work for EIT: At the Ellison Institute, we believe a collaborative, inclusive team is key to our success. We are building a supportive environment where creative risks are encouraged, and everyone feels heard. Valuing emotional intelligence, empathy, respect, and resilience, we encourage people to be curious and to have a shared commitment to excellence. Join us and make an impact! Terms of Appointment: You must have the right to work permanently in the UK with a willingness to travel as necessary. You will live in, or within easy commuting distance of, Oxford. During peak periods, some longer hours may be required and some working across multiple time zones due to the global nature of the programme.
Fulfil your potential in hospitals that make history: Charing Cross, Hammersmith, St Mary's, Queen Charlotte's & Chelsea and Western Eye. With five world-renowned hospitals, Imperial College Healthcare NHS Trust is full of opportunity if you are looking to develop your healthcare career. We are an NHS Trust of approximately 16,000 people, providing care for over a million and a half patients from north west London and beyond every year. We have a rich heritage and an ambitious vision for the future of our patients and local communities. With our partners, Imperial College London, and The Royal Marsden NHS Foundation Trust, we form Imperial College Academic Health Science Centre, one of 6 academic health science centres in the UK, working to ensure the rapid translation of research for better patient care and excellence in education. We are proud of our heritage in innovation and we are early adopters of new insights in technologies, techniques and treatments for improving health. Job overview Join us as a Principal Magnetic Resonance Physicist on a fixed-term basis to cover maternity leave at Imperial College Healthcare NHS Trust. Based across our hospital sites, you'll provide expert MR physics support and MR safety advice across the Trust and external service partners. We're looking for an HCPC registered, experienced clinical scientist with the confidence to work autonomously and collaboratively. Main duties of the job You will be involved in the delivery of expert scientific and technical support for MRI across Imperial College Healthcare NHS Trust and its external partners. Acting as a senior member of the MR physics team, you'll be responsible for overseeing MR quality assurance programmes, troubleshooting system issues, supporting procurement, and optimising clinical protocols. You will act as a recognised Magnetic Resonance Safety Expert (MRSE), providing high-level safety advice and guidance to radiographers, radiologists, and other clinical staff. You'll also play a vital role in teaching and training STP trainees, junior staff, and postgraduate students. This role requires strong communication, advanced problem-solving skills, and the ability to manage complex projects independently while working collaboratively within a multidisciplinary team. Working for our organisation At Imperial College Healthcare you can achieve extraordinary things with extraordinary people, working with leading clinicians pushing boundaries in patient care. Become part of a vibrant team living our values - expert, kind, collaborative and aspirational. You'll get an experience like no other and will fast forward your career. Benefits include career development, flexible working and wellbeing, staff recognition scheme. Make use of optional benefits including Cycle to Work, car lease schemes, season ticket loan or membership options for onsite leisure facilities. We are committed to equal opportunities and improving the working lives of our staff and will consider applications to work flexibly, part time or job share. Please talk to us at interview. . Detailed job description and main responsibilities The full job description provides an overview of the key tasks and responsibilities of the role and the person specification outlines the qualifications, skills, experience and knowledge required. For both overviews please view the Job Description attachment with the job advert. Person specification Education Honours Degree in a Physical Science MSc in Medical Physics or equivalent subject or equivalent experience Registration with the Health and Care Professions Council (HCPC) Advanced professional training in magnetic resonance physics or equivalent 1st or 2nd class honours degree PhD in a relevant subject Skills Proven competence in understanding and application of MR physics and safety Specialist knowledge and understanding of regulations, recommendations and guidelines Self-motivated/ability for problem solving and decision making Able to work independently providing specialist advice to the Trust and SLA customers Experience Significant experience in application of MR physics in a clinical environment Specialist experience in MR systems, image acquisition and image processing Experience in giving responsible MR safety advice Experience in teaching and training junior staff members and STP trainees Please ensure you check your emails regularly as this is how we will communicate with you throughout the recruitment process. If you are shortlisted you will be contacted by email and text message (if you provide a mobile contact number). Employer certification / accreditation badges You must have appropriate UK professional registration. The postholder will have access to vulnerable people in the course of their normal duties and as such this post is subject to the Rehabilitation of Offenders Act 1974 (Exceptions) Order 1975 (Amendment) (England and Wales) Order 2020 and as such it will be necessary for a submission for Disclosure to be made to the Disclosure and Barring Service to check for any previous criminal convictions.
Jul 16, 2025
Full time
Fulfil your potential in hospitals that make history: Charing Cross, Hammersmith, St Mary's, Queen Charlotte's & Chelsea and Western Eye. With five world-renowned hospitals, Imperial College Healthcare NHS Trust is full of opportunity if you are looking to develop your healthcare career. We are an NHS Trust of approximately 16,000 people, providing care for over a million and a half patients from north west London and beyond every year. We have a rich heritage and an ambitious vision for the future of our patients and local communities. With our partners, Imperial College London, and The Royal Marsden NHS Foundation Trust, we form Imperial College Academic Health Science Centre, one of 6 academic health science centres in the UK, working to ensure the rapid translation of research for better patient care and excellence in education. We are proud of our heritage in innovation and we are early adopters of new insights in technologies, techniques and treatments for improving health. Job overview Join us as a Principal Magnetic Resonance Physicist on a fixed-term basis to cover maternity leave at Imperial College Healthcare NHS Trust. Based across our hospital sites, you'll provide expert MR physics support and MR safety advice across the Trust and external service partners. We're looking for an HCPC registered, experienced clinical scientist with the confidence to work autonomously and collaboratively. Main duties of the job You will be involved in the delivery of expert scientific and technical support for MRI across Imperial College Healthcare NHS Trust and its external partners. Acting as a senior member of the MR physics team, you'll be responsible for overseeing MR quality assurance programmes, troubleshooting system issues, supporting procurement, and optimising clinical protocols. You will act as a recognised Magnetic Resonance Safety Expert (MRSE), providing high-level safety advice and guidance to radiographers, radiologists, and other clinical staff. You'll also play a vital role in teaching and training STP trainees, junior staff, and postgraduate students. This role requires strong communication, advanced problem-solving skills, and the ability to manage complex projects independently while working collaboratively within a multidisciplinary team. Working for our organisation At Imperial College Healthcare you can achieve extraordinary things with extraordinary people, working with leading clinicians pushing boundaries in patient care. Become part of a vibrant team living our values - expert, kind, collaborative and aspirational. You'll get an experience like no other and will fast forward your career. Benefits include career development, flexible working and wellbeing, staff recognition scheme. Make use of optional benefits including Cycle to Work, car lease schemes, season ticket loan or membership options for onsite leisure facilities. We are committed to equal opportunities and improving the working lives of our staff and will consider applications to work flexibly, part time or job share. Please talk to us at interview. . Detailed job description and main responsibilities The full job description provides an overview of the key tasks and responsibilities of the role and the person specification outlines the qualifications, skills, experience and knowledge required. For both overviews please view the Job Description attachment with the job advert. Person specification Education Honours Degree in a Physical Science MSc in Medical Physics or equivalent subject or equivalent experience Registration with the Health and Care Professions Council (HCPC) Advanced professional training in magnetic resonance physics or equivalent 1st or 2nd class honours degree PhD in a relevant subject Skills Proven competence in understanding and application of MR physics and safety Specialist knowledge and understanding of regulations, recommendations and guidelines Self-motivated/ability for problem solving and decision making Able to work independently providing specialist advice to the Trust and SLA customers Experience Significant experience in application of MR physics in a clinical environment Specialist experience in MR systems, image acquisition and image processing Experience in giving responsible MR safety advice Experience in teaching and training junior staff members and STP trainees Please ensure you check your emails regularly as this is how we will communicate with you throughout the recruitment process. If you are shortlisted you will be contacted by email and text message (if you provide a mobile contact number). Employer certification / accreditation badges You must have appropriate UK professional registration. The postholder will have access to vulnerable people in the course of their normal duties and as such this post is subject to the Rehabilitation of Offenders Act 1974 (Exceptions) Order 1975 (Amendment) (England and Wales) Order 2020 and as such it will be necessary for a submission for Disclosure to be made to the Disclosure and Barring Service to check for any previous criminal convictions.
Press Tab to Move to Skip to Content Link Select how often (in days) to receive an alert: Select how often (in days) to receive an alert: We are currently looking for a Senior Software Engineer to join our Research and Development team, based in Dunfermline. Our software development team work within a SAFe, agile framework, utilising the Atlassian suite (Jira, Bitbucket, Confluence, Bamboo) to control sprints, builds, merges & deployments, with a sophisticated DevOps process to automatically build, deploy, test and measure continuously the quality of our software (CI/CD). Working daily with a highly skilled & innovative team of hardware, optical & mechanical and algorithm engineers & data scientists, you will design, develop, and test software to support a diverse range of technologies to image the eye to control, compute, analyse, automate, and optimize the retinal imaging process, leading to world leading insights into diseases and disorders of the eye. It's all about the data! ESSENTIAL DUTIES AND RESPONSIBILITIES Requirements capture and analysis Participates in technical requirements capture and contributes to technical requirements specifications that satisfy marketing requirements for new/updated software features. Demonstrates best practise and ensures requirements are precise, unambiguous and testable. Software Design Designs new software features and updates existing features, ensuring that all new design satisfies functional and non-functional requirements, maximises re-use of concepts and existing assets, supports future re-use where required, and is maintainable. Creates design documentation using UML. Defines interfaces to other internal systems. Ensures they are reviewed by representatives of the affected development teams, and gains agreement on the final interface specification. When developing user-facing software, creates scenarios, process flows, information architecture diagrams, wireframes, and other artefacts required to develop and evolve user experience designs. Delivers User Interfaces based on specifications and usability guidelines. Implementation and unit testing Implements new software features and updates existing features by following defined coding standards. Ensures all code is integrated into the automated build process on a frequent and regular basis. Performs unit testing and where possible, ensures the tests are run as part of the continuous integration process. Reviews other engineers' code to identify design or implementation errors, weaknesses, omissions, and deviations from published coding guidelines. Software Quality Debugs, troubleshoots and diagnoses performance and functional issues with Optos systems at differing stages of the lifecycle (development, test, production and field). Performs investigation of unit test failures to identify changes required to existing code or tests. Ensures all work is peer reviewed and has constructive dialog with reviewers to agree what updates/rework are required. Recommends improvements to Software team working practices, tools and environment. Suggests changes to current Optos systems to improve efficiency and quality of software development. All activities to be carried out in compliance with the Optos SDLC, ISO13485 and FDA Medical Device Design Control processes. MINIMUM QUALIFICATIONS Educated to degree level in a software engineering discipline or equivalent education gained through work experience. 5+ years' experience in designing and developing software using OO techniques. Experience in requirements capture and technical documentation generation. Proven commercial experience of software development in a Waterfall and/or Agile environment. Extensive experience with C# and .net. Experience in performing unit and component testing of software modules. Good fundamental and hands on knowledge of MS SQL Server or equivalent database technology. Experience of applying continuous integration. Experience in using configuration management tools and bug reporting/resolution. Experience in customer facing support and issue resolution. Proven commercial experience of application software development and project work in a regulated Medical Device, or equivalent environment. Strong written and verbal communication skills, proficient in writing technical documents. Proven time management skills with the ability to meet challenging deadlines. BENEFITS At Optos, we offer a highly competitive compensation and benefits package. EQUAL OPPORTUNITIES EMPLOYER We are an equal opportunities employer and welcome applications from all suitably qualified persons regardless of their race, sex, disability, religion/belief, sexual orientation, age or protected veteran status. If you feel you have the necessary skills and experience and want to join a great team, please click on the Apply button!
Jul 16, 2025
Full time
Press Tab to Move to Skip to Content Link Select how often (in days) to receive an alert: Select how often (in days) to receive an alert: We are currently looking for a Senior Software Engineer to join our Research and Development team, based in Dunfermline. Our software development team work within a SAFe, agile framework, utilising the Atlassian suite (Jira, Bitbucket, Confluence, Bamboo) to control sprints, builds, merges & deployments, with a sophisticated DevOps process to automatically build, deploy, test and measure continuously the quality of our software (CI/CD). Working daily with a highly skilled & innovative team of hardware, optical & mechanical and algorithm engineers & data scientists, you will design, develop, and test software to support a diverse range of technologies to image the eye to control, compute, analyse, automate, and optimize the retinal imaging process, leading to world leading insights into diseases and disorders of the eye. It's all about the data! ESSENTIAL DUTIES AND RESPONSIBILITIES Requirements capture and analysis Participates in technical requirements capture and contributes to technical requirements specifications that satisfy marketing requirements for new/updated software features. Demonstrates best practise and ensures requirements are precise, unambiguous and testable. Software Design Designs new software features and updates existing features, ensuring that all new design satisfies functional and non-functional requirements, maximises re-use of concepts and existing assets, supports future re-use where required, and is maintainable. Creates design documentation using UML. Defines interfaces to other internal systems. Ensures they are reviewed by representatives of the affected development teams, and gains agreement on the final interface specification. When developing user-facing software, creates scenarios, process flows, information architecture diagrams, wireframes, and other artefacts required to develop and evolve user experience designs. Delivers User Interfaces based on specifications and usability guidelines. Implementation and unit testing Implements new software features and updates existing features by following defined coding standards. Ensures all code is integrated into the automated build process on a frequent and regular basis. Performs unit testing and where possible, ensures the tests are run as part of the continuous integration process. Reviews other engineers' code to identify design or implementation errors, weaknesses, omissions, and deviations from published coding guidelines. Software Quality Debugs, troubleshoots and diagnoses performance and functional issues with Optos systems at differing stages of the lifecycle (development, test, production and field). Performs investigation of unit test failures to identify changes required to existing code or tests. Ensures all work is peer reviewed and has constructive dialog with reviewers to agree what updates/rework are required. Recommends improvements to Software team working practices, tools and environment. Suggests changes to current Optos systems to improve efficiency and quality of software development. All activities to be carried out in compliance with the Optos SDLC, ISO13485 and FDA Medical Device Design Control processes. MINIMUM QUALIFICATIONS Educated to degree level in a software engineering discipline or equivalent education gained through work experience. 5+ years' experience in designing and developing software using OO techniques. Experience in requirements capture and technical documentation generation. Proven commercial experience of software development in a Waterfall and/or Agile environment. Extensive experience with C# and .net. Experience in performing unit and component testing of software modules. Good fundamental and hands on knowledge of MS SQL Server or equivalent database technology. Experience of applying continuous integration. Experience in using configuration management tools and bug reporting/resolution. Experience in customer facing support and issue resolution. Proven commercial experience of application software development and project work in a regulated Medical Device, or equivalent environment. Strong written and verbal communication skills, proficient in writing technical documents. Proven time management skills with the ability to meet challenging deadlines. BENEFITS At Optos, we offer a highly competitive compensation and benefits package. EQUAL OPPORTUNITIES EMPLOYER We are an equal opportunities employer and welcome applications from all suitably qualified persons regardless of their race, sex, disability, religion/belief, sexual orientation, age or protected veteran status. If you feel you have the necessary skills and experience and want to join a great team, please click on the Apply button!
Contract - Initially a 2 year fixed term contract - onsite. Salary - £40,000 - £45,000 depending on experience. Our client are a scientifically passionate company who lead extensive collaborations and offer services to the Drug Discovery and Disease Research sectors. They collaborate with lead researchers and organisations to enhance the understanding of immunological, oncological, neurological and other disease areas. Based in Alderley Park, they are offering an exciting opportunity for an enthusiastic and hard-working individual to join their in vivo imaging team as a Senior Scientist. If you are looking to work on exciting translational in vivo imaging projects and want to further your career, then this could be the opportunity you have been waiting for. The Role This is a role for experienced Imaging Scientists who hold a PhD (or Master's) in a biologically focused discipline, with additional postdoctoral or industry experience. As a Senior Imaging Scientist, you will be responsible for: Designing and running mouse + rodent PET / in vivo imaging studies for a range of purposes including biodistribution, pharmacokinetics (PK) and cellular responses. Leading exciting projects relating to lipid nanoparticle based therapeutics. Delivery of high quality experimental data and presenting this to external partners. Oversee and manage projects spanning multiple organisations, from conception to completion. Innovating in the in vivo imaging space to bring new technologies or ways of applying the technology to projects. Adhering to regulations and guidelines for in vivo work, including Home-Office project licence. Labelling / radiolabelling of LNPs (optional) Skills and Experience Needed: Suitable applicants must have: A PhD or Master's - focused around biological imaging (essential) Significant experience of developing pre-clinical in vivo mouse and rodent models (essential) Hold a personal Home Office PIL ABC licence (essential) Must have significant experience in positron emission tomography (PET) imaging and data analysis + image reconstruction tools (essential) Proven experience of routine in vivo techniques such as tissue collection, blood sampling, dosing via common routes etc (essential) Experience in leading, or influencing complex scientific projects (essential) Strong experience in ex vivo techniques like immunohistochemistry (IHC), immunofluorescence staining, microscopy etc (essential) Good communication and problem-solving skills (essential) Suitable applicants could have: Experience working on complex projects spanning across multiple organisation types (CRO, biotech, medical research charity, academia, etc) (desired) Experience in other in vivo imaging techniques including SPECT, IVIS, MRI etc (nice to have) PMOD image analysis software experience (desired) Radioligand labelling experience (nice to have) Working on lipid nanoparticle (LNP) within formulation, dosing or translational studies (nice to have) Prior industry experience in an SME or pharmaceutical company (desired) The Package Being a leading collaborative drug discovery company, our client is offering the chance to be part of a growing organisation on a temporary basis, with a competitive salary and benefits package. To Apply If you would like to submit an application for this position, please contact Charlie Cox on , or send an email to I'm interested in this job Please use the form provided to get in touch with us and we will respond as soon as possible. Compulsory fields are in bold . I'm interested in this job Please use the form provided to get in touch with us and we will respond as soon as possible. Compulsory fields are in bold . Name Email address Telephone Message Upload C.V. Your file must be in one of the following formats: pdf , doc , docx , rtf , txt and no larger than 2MB . Recaptcha requires verification. I'm not a robot reCAPTCHA Privacy - Terms
Jul 15, 2025
Full time
Contract - Initially a 2 year fixed term contract - onsite. Salary - £40,000 - £45,000 depending on experience. Our client are a scientifically passionate company who lead extensive collaborations and offer services to the Drug Discovery and Disease Research sectors. They collaborate with lead researchers and organisations to enhance the understanding of immunological, oncological, neurological and other disease areas. Based in Alderley Park, they are offering an exciting opportunity for an enthusiastic and hard-working individual to join their in vivo imaging team as a Senior Scientist. If you are looking to work on exciting translational in vivo imaging projects and want to further your career, then this could be the opportunity you have been waiting for. The Role This is a role for experienced Imaging Scientists who hold a PhD (or Master's) in a biologically focused discipline, with additional postdoctoral or industry experience. As a Senior Imaging Scientist, you will be responsible for: Designing and running mouse + rodent PET / in vivo imaging studies for a range of purposes including biodistribution, pharmacokinetics (PK) and cellular responses. Leading exciting projects relating to lipid nanoparticle based therapeutics. Delivery of high quality experimental data and presenting this to external partners. Oversee and manage projects spanning multiple organisations, from conception to completion. Innovating in the in vivo imaging space to bring new technologies or ways of applying the technology to projects. Adhering to regulations and guidelines for in vivo work, including Home-Office project licence. Labelling / radiolabelling of LNPs (optional) Skills and Experience Needed: Suitable applicants must have: A PhD or Master's - focused around biological imaging (essential) Significant experience of developing pre-clinical in vivo mouse and rodent models (essential) Hold a personal Home Office PIL ABC licence (essential) Must have significant experience in positron emission tomography (PET) imaging and data analysis + image reconstruction tools (essential) Proven experience of routine in vivo techniques such as tissue collection, blood sampling, dosing via common routes etc (essential) Experience in leading, or influencing complex scientific projects (essential) Strong experience in ex vivo techniques like immunohistochemistry (IHC), immunofluorescence staining, microscopy etc (essential) Good communication and problem-solving skills (essential) Suitable applicants could have: Experience working on complex projects spanning across multiple organisation types (CRO, biotech, medical research charity, academia, etc) (desired) Experience in other in vivo imaging techniques including SPECT, IVIS, MRI etc (nice to have) PMOD image analysis software experience (desired) Radioligand labelling experience (nice to have) Working on lipid nanoparticle (LNP) within formulation, dosing or translational studies (nice to have) Prior industry experience in an SME or pharmaceutical company (desired) The Package Being a leading collaborative drug discovery company, our client is offering the chance to be part of a growing organisation on a temporary basis, with a competitive salary and benefits package. To Apply If you would like to submit an application for this position, please contact Charlie Cox on , or send an email to I'm interested in this job Please use the form provided to get in touch with us and we will respond as soon as possible. Compulsory fields are in bold . I'm interested in this job Please use the form provided to get in touch with us and we will respond as soon as possible. Compulsory fields are in bold . Name Email address Telephone Message Upload C.V. Your file must be in one of the following formats: pdf , doc , docx , rtf , txt and no larger than 2MB . Recaptcha requires verification. I'm not a robot reCAPTCHA Privacy - Terms
Main area Physics Grade NHS AfC: Band 7 Contract 12 months (Fixed term (until 29-Aug-2026 Hours Full time - 37.5 hours per week Job ref 282-SB661 Employer The Royal Marsden NHS Foundation Trust Employer type NHS Site The Royal Marsden Sutton Town Sutton Salary £51,883 - £58,544 per annum Salary period Yearly Closing 23/07/:59 Job overview We are looking for an enthusiastic clinical physicist to join the Radiotherapy Physics group at band 7 at the Sutton branch of the Royal Marsden Hospital, on a fixed term appointment until August 2026. Extensions are possible but cannot be guaranteed at this time. An appointment may be made at a lower band for a less qualified candidate. As part of the physics team, you will support all radiotherapy work at a specialist centre. Treatment planning is performed using the RayStation treatment planning system, with most treatment sites planned using a VMAT technique. We have established workflows for adaptive radiotherapy (both online adaptive and plan of the day), 4DCT, and breathhold techniques. Multimodality imaging (CT, PET-CT, MR) is used for planning of several treatment sites. Recent clinical development work has included developing planning and quality control techniques for helical delivery on our new Radixact units. The Radiotherapy Department in Sutton has 5 Elekta linacs, an Elekta Unity MR-Linac, a Cyberknife S7, two Accuray Radixacts and an XStrahl superficial unit. The radiotherapy physics group consists of 40 physicists, dosimetrists and engineers and forms a substantial part of the Royal Marsden/Institute of Cancer Research Joint Department of Physics, through which we have many active research collaborations, most notably on the MR-linac which was the first in the UK to treat patients. Main duties of the job The post holder will provide specialist support to all aspects of the clinical, scientific and technical Radiotherapy Physics Service to Radiotherapy. The post holder has particular clinical and scientific responsibilities for day-to-day essential complex treatment planning and checking and performing Quality Assurance and dosimetry and analysing results. Responsible for ensuring radiographers and trainee clinical scientists are supervised and assisted in their training and to act as their mentor. Supervise and assign junior staff and participate on clinical duties as outlined in the activities of the Radiotherapy Physics Group on a day-to-day basis as indicted by the duty rota. Work closely with the Principal Physicist in all areas. Working for our organisation The Royal Marsden NHS Foundation Trust is a world-leading cancer centre. Our role is to offer our patients the best cancer care available anywhere in the world, and to continue to make a global contribution to finding better ways of diagnosing and treating cancer. We employ over 4,500 staff in a diverse range of careers including nursing, medical, science, radiography, pharmacy, occupational therapy, finance and administrative services. We have two hospitals - one in Chelsea, London, and one in Sutton, Surrey - as well as a Medical Daycare Unit in Kingston Hospital. At The Royal Marsden, we deal with cancer every day, so we understand how valuable life is. When people entrust their lives to us, they have the right to demand the very best. That's why the pursuit of excellence lies at the heart of everything we do. At the heart of the hospital is our dedicated team. We offer a stimulating and dynamic working environment, a wide range of staff benefits, learning and development opportunities and clear career pathways. There are opportunities to work flexibly across a range of areas and specialities and we welcome flexible working requests from point of hire to support employees work life balance. We are looking for employees who aspire to excellence, share our values and can play a crucial role in our on-going achievements. Detailed job description and main responsibilities For further information on this role, please see the attached detailed Job Description and Person Specification: Participate in the commissioning of new radiotherapy treatment equipment, including the preparation and checking of complex beam data for treatment planning systems. Perform and advise on dosimetry measurements in patients. Provide complex advice to clinical staff and support developments in treatment planning. Replan patient treatments where required, following a treatment error or changes in patient shape. Use judgement to analyse and determine the most appropriate compensation method. Calculate the compensation required and subsequent patient dose. Carry out manual dose calculations. Check and approve routine and complex treatment plans, dose calculations and templates produced by other members of staff. Person specification Scientific Grades Good (1st or 2nd class) Honours degree in a relevant subject MSc in radiation Physics (or equivalent) PhD in relevant subject or equivalent specialised scientific knowledge IPEM Diploma or equivalent in Medical Physics or Medical Engineering. Registration Close to achieving or HCPC Registered as a Clinical Scientist Scientific/Technical/Specialist Basic knowledge across the range of working procedures and practices in radiotherapy physics, building on theoretical knowledge and practical experience. Practical experience in clinical radiotherapy treatment planning and in the use of dosimetry equipment in radiotherapy Specialist training on and practical experience with a range of radiotherapy treatment & simulation/scanning equipment, including clinical applications. IT Able to use Excel, Word, etc.to set up documents and spreadsheets, extract information Able to set up and manage the acquisition, structure and networking of information, including image transfer formats Experience in programming (e.g. in one or more of Python, C++, JAVA, R, MATLAB) Communication Able to communicate highly complex information at postgraduate level to other professional groups Able to present scientific papers at national and international conferences and write up scientific material for publication The Royal Marsden values diversity and is committed to the recruitment and retention of underrepresented minority groups. We particularly welcome applications from Black, Asian and minority ethnic candidates, LGBTQ+ candidates and candidates with disabilities. As a Disability Confident Employer, we are working to create a workplace that enables all staff to reach their full potential. We are committed to this because we know that greater diversity and inclusion will lead to an even greater positive impact for the people we serve. Due to the high volumes of applications we receive, we reserve the right to close any adverts before the published closing date once we have received a sufficient number of applications. We advise you to submit your application as early as possible to prevent disappointment. All applicants will be contacted by email to the address supplied on your application. Applicants are advised to check their email accounts regularly and to ensure that email filters are set to allow our emails. Flu Vaccination - What We Expect of our Staff At The Royal Marsden we have an immune compromised patient population who we must protect as much as we can against the flu virus. Each year, seasonal flu affects thousands of people in the UK. Occurring mainly in winter, it is an infectious respiratory disease capable of producing symptoms ranging from those similar to a common cold, through to very severe or even fatal disease. The wellbeing of our staff and patients is of the upmost importance to us, and it is the expectation of The Royal Marsden that all patient-facing staff have an annual flu vaccination, provided free of charge by the Trust. Employer certification / accreditation badges You must have appropriate UK professional registration. This post is subject to the Rehabilitation of Offenders Act 1974 (Exceptions) Order 1975 (Amendment) (England and Wales) Order 2020 and it will be necessary for a submission for Disclosure to be made to the Disclosure and Barring Service.
Jul 15, 2025
Full time
Main area Physics Grade NHS AfC: Band 7 Contract 12 months (Fixed term (until 29-Aug-2026 Hours Full time - 37.5 hours per week Job ref 282-SB661 Employer The Royal Marsden NHS Foundation Trust Employer type NHS Site The Royal Marsden Sutton Town Sutton Salary £51,883 - £58,544 per annum Salary period Yearly Closing 23/07/:59 Job overview We are looking for an enthusiastic clinical physicist to join the Radiotherapy Physics group at band 7 at the Sutton branch of the Royal Marsden Hospital, on a fixed term appointment until August 2026. Extensions are possible but cannot be guaranteed at this time. An appointment may be made at a lower band for a less qualified candidate. As part of the physics team, you will support all radiotherapy work at a specialist centre. Treatment planning is performed using the RayStation treatment planning system, with most treatment sites planned using a VMAT technique. We have established workflows for adaptive radiotherapy (both online adaptive and plan of the day), 4DCT, and breathhold techniques. Multimodality imaging (CT, PET-CT, MR) is used for planning of several treatment sites. Recent clinical development work has included developing planning and quality control techniques for helical delivery on our new Radixact units. The Radiotherapy Department in Sutton has 5 Elekta linacs, an Elekta Unity MR-Linac, a Cyberknife S7, two Accuray Radixacts and an XStrahl superficial unit. The radiotherapy physics group consists of 40 physicists, dosimetrists and engineers and forms a substantial part of the Royal Marsden/Institute of Cancer Research Joint Department of Physics, through which we have many active research collaborations, most notably on the MR-linac which was the first in the UK to treat patients. Main duties of the job The post holder will provide specialist support to all aspects of the clinical, scientific and technical Radiotherapy Physics Service to Radiotherapy. The post holder has particular clinical and scientific responsibilities for day-to-day essential complex treatment planning and checking and performing Quality Assurance and dosimetry and analysing results. Responsible for ensuring radiographers and trainee clinical scientists are supervised and assisted in their training and to act as their mentor. Supervise and assign junior staff and participate on clinical duties as outlined in the activities of the Radiotherapy Physics Group on a day-to-day basis as indicted by the duty rota. Work closely with the Principal Physicist in all areas. Working for our organisation The Royal Marsden NHS Foundation Trust is a world-leading cancer centre. Our role is to offer our patients the best cancer care available anywhere in the world, and to continue to make a global contribution to finding better ways of diagnosing and treating cancer. We employ over 4,500 staff in a diverse range of careers including nursing, medical, science, radiography, pharmacy, occupational therapy, finance and administrative services. We have two hospitals - one in Chelsea, London, and one in Sutton, Surrey - as well as a Medical Daycare Unit in Kingston Hospital. At The Royal Marsden, we deal with cancer every day, so we understand how valuable life is. When people entrust their lives to us, they have the right to demand the very best. That's why the pursuit of excellence lies at the heart of everything we do. At the heart of the hospital is our dedicated team. We offer a stimulating and dynamic working environment, a wide range of staff benefits, learning and development opportunities and clear career pathways. There are opportunities to work flexibly across a range of areas and specialities and we welcome flexible working requests from point of hire to support employees work life balance. We are looking for employees who aspire to excellence, share our values and can play a crucial role in our on-going achievements. Detailed job description and main responsibilities For further information on this role, please see the attached detailed Job Description and Person Specification: Participate in the commissioning of new radiotherapy treatment equipment, including the preparation and checking of complex beam data for treatment planning systems. Perform and advise on dosimetry measurements in patients. Provide complex advice to clinical staff and support developments in treatment planning. Replan patient treatments where required, following a treatment error or changes in patient shape. Use judgement to analyse and determine the most appropriate compensation method. Calculate the compensation required and subsequent patient dose. Carry out manual dose calculations. Check and approve routine and complex treatment plans, dose calculations and templates produced by other members of staff. Person specification Scientific Grades Good (1st or 2nd class) Honours degree in a relevant subject MSc in radiation Physics (or equivalent) PhD in relevant subject or equivalent specialised scientific knowledge IPEM Diploma or equivalent in Medical Physics or Medical Engineering. Registration Close to achieving or HCPC Registered as a Clinical Scientist Scientific/Technical/Specialist Basic knowledge across the range of working procedures and practices in radiotherapy physics, building on theoretical knowledge and practical experience. Practical experience in clinical radiotherapy treatment planning and in the use of dosimetry equipment in radiotherapy Specialist training on and practical experience with a range of radiotherapy treatment & simulation/scanning equipment, including clinical applications. IT Able to use Excel, Word, etc.to set up documents and spreadsheets, extract information Able to set up and manage the acquisition, structure and networking of information, including image transfer formats Experience in programming (e.g. in one or more of Python, C++, JAVA, R, MATLAB) Communication Able to communicate highly complex information at postgraduate level to other professional groups Able to present scientific papers at national and international conferences and write up scientific material for publication The Royal Marsden values diversity and is committed to the recruitment and retention of underrepresented minority groups. We particularly welcome applications from Black, Asian and minority ethnic candidates, LGBTQ+ candidates and candidates with disabilities. As a Disability Confident Employer, we are working to create a workplace that enables all staff to reach their full potential. We are committed to this because we know that greater diversity and inclusion will lead to an even greater positive impact for the people we serve. Due to the high volumes of applications we receive, we reserve the right to close any adverts before the published closing date once we have received a sufficient number of applications. We advise you to submit your application as early as possible to prevent disappointment. All applicants will be contacted by email to the address supplied on your application. Applicants are advised to check their email accounts regularly and to ensure that email filters are set to allow our emails. Flu Vaccination - What We Expect of our Staff At The Royal Marsden we have an immune compromised patient population who we must protect as much as we can against the flu virus. Each year, seasonal flu affects thousands of people in the UK. Occurring mainly in winter, it is an infectious respiratory disease capable of producing symptoms ranging from those similar to a common cold, through to very severe or even fatal disease. The wellbeing of our staff and patients is of the upmost importance to us, and it is the expectation of The Royal Marsden that all patient-facing staff have an annual flu vaccination, provided free of charge by the Trust. Employer certification / accreditation badges You must have appropriate UK professional registration. This post is subject to the Rehabilitation of Offenders Act 1974 (Exceptions) Order 1975 (Amendment) (England and Wales) Order 2020 and it will be necessary for a submission for Disclosure to be made to the Disclosure and Barring Service.
The Onyx Research Data Tech organization is GSK's Research data ecosystem which has the capability to bring together, analyze, and power the exploration of data at scale. We partner with scientists across GSK to define and understand their challenges and develop tailored solutions that meet their needs. The goal is to ensure scientists have the right data and insights when they need it to give them a better starting point for and accelerate medical discovery. Ultimately, this helps us get ahead of disease in more predictive and powerful ways. Onyx is a full-stack shop consisting of product and portfolio leadership, data engineering, infrastructure and DevOps, data / metadata / knowledge platforms, and AI/ML and analysis platforms, all geared toward: Building a next-generation, metadata- and automation-driven data experience for GSK's scientists, engineers, and decision-makers, increasing productivity and reducing time spent on "data mechanics". Providing best-in-class AI/ML and data analysis environments to accelerate our predictive capabilities and attract top-tier talent. Aggressively engineering our data at scale, as one unified asset, to unlock the value of our unique collection of data and predictions in real-time. Onyx Product Management is at the heart of our mission, ensuring that everything from our infrastructure, to platforms, to end-user facing data assets and environments is designed to maximize our impact on R&D. The Product Management team partners with R&D stakeholders and Onyx leadership to develop a strategic roadmap for all customer-facing aspects of Onyx, including data assets, ontology, Knowledge Graph / semantic search, data / computing / analysis platforms, and data-powered applications. We are seeking a highly skilled and experienced Senior Product Manager, AIML Platform. In this role, you will be responsible for developing the product strategy of our AI/ML Platform to meet customer needs. You will partner closely with the leaders of Onyx's customer organizations, including AI/ML, a diversity of R&D teams utilizing data to accelerate drug discovery (genomics sciences, computational biology, imaging, computational chemistry, to name a few), along with the Onyx portfolio management and engineering function heads to deliver industry-leading solutions that power AI/ML workloads. You will drive the product roadmap, guide product development initiatives, and ensure the successful launch and adoption of our AI/ML Platform. Together, you will facilitate joint planning and execution of the product roadmap, ensuring a balance between strategic development and customer-facing deliverables. You will also play a key role in devising, tracking, and publicizing metrics that measure the impact and performance of Onyx AI/ML platform products. Additionally, as the organization scales, you will be responsible for hiring, developing, and retaining a talented team of Product Managers who possess a deep understanding of the business areas, Onyx capabilities, and how to translate customer needs into requirements aligned with standard frameworks such as ontologies and engineering pipelines. This ensures our AI/ML scientists receive the solutions they need to succeed. Key Responsibilities: Product Strategy: Develop and execute a comprehensive product strategy for our AI/ML Platform product, aligning with Onyx's overall goals and objectives. Roadmap Development: Define and prioritize features, enhancements, and functionalities for the platform based on user analysis, customer feedback, and business requirements. Cross-functional Collaboration: Collaborate closely with engineering, AI/ML, and portfolio teams to ensure successful product development and deployment. Stakeholder Engagement: Collaborate with customers, partners, and internal stakeholders to understand their needs, gather feedback, and incorporate it into product planning and development processes. Product Launch: Plan and oversee product launches, ensuring effective communication, documentation, and training to drive product adoption and success. Performance Measurement: Define key product metrics, establish monitoring systems, and regularly evaluate and report on the performance and success of the AI/ML platform. Product Ambassador: Serve as an ambassador of the AI/ML platform, effectively communicating its value and benefits to GSK Research and Development leadership and identifying potential customers. Industry Expertise: Stay up to date with the latest advancements and trends in AI, machine learning, and compute platforms, applying industry knowledge to drive innovation and competitive advantage. Team Leadership: Manage and mentor a team of product managers, providing guidance, support, and fostering a culture of innovation and excellence. Why You? Basic Qualifications: Bachelor's degree in Computer Science, Machine Learning/AI, or related discipline. 4+ years of product and/or engineering experience building AI/ML software. 2+ years of experience building cloud-based products. 2+ years of experience with at least one major cloud-based AI model development service, like Azure, Google Cloud's Vertex AI, or AWS platforms. Preferred Qualifications: Mastery of the English language, excellent communication and technical writing skills. Strong understanding of SDLC best practices, including experience with CICD and virtualization /containers. Strong understanding of MLOps. Experience with ML batch training and inference. Experience with ML Experiment tracking. Experience with ML Serving. Experience with High Performance Computing. Experience developing in Python or another commonly used scripting language. Robust experience in AI model development across the full model lifecycle and with multiple mediums (natural language, computer vision, sequences, etc.). Proven track record of managing developer platforms, tools, and / or services, ideally for research. Strong proficiency in utilizing various product management tools, including Jira and Confluence. Prior product management experience of enterprise AI/ML platform is strongly preferred. Strategic Thinker: Proven track record in developing and executing product strategies that drive business growth and customer satisfaction. Leadership Skills: Demonstrated ability to lead and inspire cross-functional teams, set clear objectives, and foster a collaborative and innovative work environment. Customer Focus: A customer-centric mindset with a deep understanding of customer needs and the ability to translate them into effective product solutions. Analytical and Data-Driven: Strong analytical skills with the ability to gather and interpret data, perform market research, and make data-driven decisions. Excellent Communication: Exceptional written and verbal communication skills, with the ability to effectively present complex ideas and concepts to both technical and non-technical audiences. Adaptability: Thrives in a fast-paced, dynamic environment and can adapt quickly to changing priorities and business needs.
Jan 25, 2025
Full time
The Onyx Research Data Tech organization is GSK's Research data ecosystem which has the capability to bring together, analyze, and power the exploration of data at scale. We partner with scientists across GSK to define and understand their challenges and develop tailored solutions that meet their needs. The goal is to ensure scientists have the right data and insights when they need it to give them a better starting point for and accelerate medical discovery. Ultimately, this helps us get ahead of disease in more predictive and powerful ways. Onyx is a full-stack shop consisting of product and portfolio leadership, data engineering, infrastructure and DevOps, data / metadata / knowledge platforms, and AI/ML and analysis platforms, all geared toward: Building a next-generation, metadata- and automation-driven data experience for GSK's scientists, engineers, and decision-makers, increasing productivity and reducing time spent on "data mechanics". Providing best-in-class AI/ML and data analysis environments to accelerate our predictive capabilities and attract top-tier talent. Aggressively engineering our data at scale, as one unified asset, to unlock the value of our unique collection of data and predictions in real-time. Onyx Product Management is at the heart of our mission, ensuring that everything from our infrastructure, to platforms, to end-user facing data assets and environments is designed to maximize our impact on R&D. The Product Management team partners with R&D stakeholders and Onyx leadership to develop a strategic roadmap for all customer-facing aspects of Onyx, including data assets, ontology, Knowledge Graph / semantic search, data / computing / analysis platforms, and data-powered applications. We are seeking a highly skilled and experienced Senior Product Manager, AIML Platform. In this role, you will be responsible for developing the product strategy of our AI/ML Platform to meet customer needs. You will partner closely with the leaders of Onyx's customer organizations, including AI/ML, a diversity of R&D teams utilizing data to accelerate drug discovery (genomics sciences, computational biology, imaging, computational chemistry, to name a few), along with the Onyx portfolio management and engineering function heads to deliver industry-leading solutions that power AI/ML workloads. You will drive the product roadmap, guide product development initiatives, and ensure the successful launch and adoption of our AI/ML Platform. Together, you will facilitate joint planning and execution of the product roadmap, ensuring a balance between strategic development and customer-facing deliverables. You will also play a key role in devising, tracking, and publicizing metrics that measure the impact and performance of Onyx AI/ML platform products. Additionally, as the organization scales, you will be responsible for hiring, developing, and retaining a talented team of Product Managers who possess a deep understanding of the business areas, Onyx capabilities, and how to translate customer needs into requirements aligned with standard frameworks such as ontologies and engineering pipelines. This ensures our AI/ML scientists receive the solutions they need to succeed. Key Responsibilities: Product Strategy: Develop and execute a comprehensive product strategy for our AI/ML Platform product, aligning with Onyx's overall goals and objectives. Roadmap Development: Define and prioritize features, enhancements, and functionalities for the platform based on user analysis, customer feedback, and business requirements. Cross-functional Collaboration: Collaborate closely with engineering, AI/ML, and portfolio teams to ensure successful product development and deployment. Stakeholder Engagement: Collaborate with customers, partners, and internal stakeholders to understand their needs, gather feedback, and incorporate it into product planning and development processes. Product Launch: Plan and oversee product launches, ensuring effective communication, documentation, and training to drive product adoption and success. Performance Measurement: Define key product metrics, establish monitoring systems, and regularly evaluate and report on the performance and success of the AI/ML platform. Product Ambassador: Serve as an ambassador of the AI/ML platform, effectively communicating its value and benefits to GSK Research and Development leadership and identifying potential customers. Industry Expertise: Stay up to date with the latest advancements and trends in AI, machine learning, and compute platforms, applying industry knowledge to drive innovation and competitive advantage. Team Leadership: Manage and mentor a team of product managers, providing guidance, support, and fostering a culture of innovation and excellence. Why You? Basic Qualifications: Bachelor's degree in Computer Science, Machine Learning/AI, or related discipline. 4+ years of product and/or engineering experience building AI/ML software. 2+ years of experience building cloud-based products. 2+ years of experience with at least one major cloud-based AI model development service, like Azure, Google Cloud's Vertex AI, or AWS platforms. Preferred Qualifications: Mastery of the English language, excellent communication and technical writing skills. Strong understanding of SDLC best practices, including experience with CICD and virtualization /containers. Strong understanding of MLOps. Experience with ML batch training and inference. Experience with ML Experiment tracking. Experience with ML Serving. Experience with High Performance Computing. Experience developing in Python or another commonly used scripting language. Robust experience in AI model development across the full model lifecycle and with multiple mediums (natural language, computer vision, sequences, etc.). Proven track record of managing developer platforms, tools, and / or services, ideally for research. Strong proficiency in utilizing various product management tools, including Jira and Confluence. Prior product management experience of enterprise AI/ML platform is strongly preferred. Strategic Thinker: Proven track record in developing and executing product strategies that drive business growth and customer satisfaction. Leadership Skills: Demonstrated ability to lead and inspire cross-functional teams, set clear objectives, and foster a collaborative and innovative work environment. Customer Focus: A customer-centric mindset with a deep understanding of customer needs and the ability to translate them into effective product solutions. Analytical and Data-Driven: Strong analytical skills with the ability to gather and interpret data, perform market research, and make data-driven decisions. Excellent Communication: Exceptional written and verbal communication skills, with the ability to effectively present complex ideas and concepts to both technical and non-technical audiences. Adaptability: Thrives in a fast-paced, dynamic environment and can adapt quickly to changing priorities and business needs.
Site Name: UK - Hertfordshire - Stevenage Posted Date: Sep 6 2022 Senior Scientist, Materials Science Materials Science provides holistic understanding of how structure influences particle and powder properties to design a particle process which optimises drug product processing and performance. As projects advance through development, materials scientists support project teams by performing laboratory studies, analysing data, from lead optimization up to and including the transfer and industrialization of manufacturing processes to commercial facilities. Your role will be focused on the characterisation of drug substances to support the design, selection and progression of all new drug products developed within GSK's Pharmaceutical portfolio. This will be based on generation of physical properties, biopharmaceutics and materials science understanding and knowledge created using a range of solid-state physical characterisation, structural analysis and in-vitro analytical methods. Here at our pioneering R&D Stevenage site we have a fantastic opportunity for a position in our Materials Science Team. It is predominantly lab-based and may require some travel to our other R&D site in Ware, Hertfordshire. In this role you will Design, perform and may lead physical properties analysis of drug substance and drug product when required using a range of analytical techniques, including XRPD, GVS, Raman, DSC, TGA, Optical Microscopy Design, execute and may lead work packages to relate the physical properties of drug substance and drug product to structure, performance and efficacy (e.g. solid form landscape, particle size and shape, hygroscopicity, thermal stability and bulk properties) Develop plans and execute laboratory experiments for in-vitro biorelevant measurements of a drug substance or formulation (e.g. kinetic solubility, dissolution, Intrinsic Dissolution Rate, particle imaging and permeability) across multiple projects to generate data to inform R&D decision making Work in collaboration with partners (e.g. Crystallographers, Pharmaceutical Development, Biopharmaceutics, CMC Analytical) to obtain inputs for predicting and modelling in-vivo product performance and/or aid structural understandings from physical properties Participate in method validation and technology transfer activities to GSC, other parts of R&D and partner CMO's (as appropriate for the grade) Contribute to the strategy and decision making for projects through analysis, reporting and review of data (over oversight of data from CRO's) as appropriate for the grade Ensure appropriate quality activities are performed throughout development including authoring of analytical test results. May have leadership responsibilities in quality areas. Work effectively and collaboratively on multi-disciplinary medicine development teams Confident in data management and some data interpretation, record results effectively and communicate results in technical reports Comply with local regulatory and data integrity requirements, including cGMP and GSK policies and procedures, with high quality and attention to one's own safety Why you? Qualifications & Skills: We are looking for professionals with these required skills to achieve our goals: PhD or BSc/MSc and approximately 5 years industrial experience. Effective oral and written communication skills Some years of proven working knowledge of physical and analytical chemistry Good time management and team-working skills Some years of experience in a lab-based setting Working knowledge of pharmaceutical development process Working knowledge of relating physical properties to structure and performance of drug substance and drug product Preferred Qualifications & Skills: If you have the following characteristics, it would be a plus: Some awareness of in in-vitro biorelevant measurements (e.g. solubility/dissolution, Intrinsic Dissolution Rate, transfer models) for oral biopharmaceutics Experience in solid state characterisation (e.g. XRPD, thermal analysis, microscopy, imaging, Scientific knowledge and understanding of the anatomy/physiology of body, absorption, distribution & metabolism, and integration of biopharmaceutics with formulation design across dosage forms. Why GSK? Uniting science, technology and talent to get ahead of disease together GSK is a global biopharma company with a special purpose - to unite science, technology and talent to get ahead of disease together - so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns - as an organisation where people can thrive. Getting ahead means preventing disease as well as treating it, and we aim to impact the health of 2.5 billion people around the world in the next 10 years. Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it's also about making GSK a place where people can thrive. We want GSK to be a place where people feel inspired, encouraged and challenged to be the best they can be. A place where they can be themselves - feeling welcome, valued and included. Where they can keep growing and look after their wellbeing.So, if you share our ambition, join us at this exciting moment in our journey to get Ahead Together. Find out more: Annual Report 2021 Closing Date for Applications: Friday 23rd September 2022 (COB) Please take a copy of the Job Description, as this will not be available post closure of the advert. When applying for this role, please use the 'cover letter' of the online application or your CV to describe how you meet the competencies for this role, as outlined in the job requirements above. The information that you have provided in your cover letter and CV will be used to assess your application. During the course of your application you will be requested to complete voluntary information which will be used in monitoring the effectiveness of our equality and diversity policies. Your information will be treated as confidential and will not be used in any part of the selection process. If you require a reasonable adjustment to the application / selection process to enable you to demonstrate your ability to perform the job requirements, please contact . This will help us to understand any modifications we may need to make to support you throughout our selection process. LI-GSK As a company driven by our values of Patient focus, Transparency, Respect and Integrity, we know inclusion and diversity are essential for us to be able to succeed. We want all our colleagues to thrive at GSK bringing their unique experiences, ensuring they feel good and to keep growing their careers. As a candidate for a role, we want you to feel the same way. As an Equal Opportunity Employer, we are open to all talent. In the US, we also adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to neurodiversity, race/ethnicity, colour, national origin, religion, gender, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class ( US only). We believe in an agile working culture for all our roles. If flexibility is important to you, we encourage you to explore with our hiring team what the opportunities are. Please don't hesitate to contact us if you'd like to discuss any adjustments to our process which might help you demonstrate your strengths and capabilities. You can either call us on , or send an email As you apply, we will ask you to share some personal information which is entirely voluntary. We want to have an opportunity to consider a diverse pool of qualified candidates and this information will assist us in meeting that objective and in understanding how well we are doing against our inclusion and diversity ambitions. We would really appreciate it if you could take a few moments to complete it. Rest assured, Hiring Managers do not have access to this information and we will treat your information confidentially. Important notice to Employment businesses/ Agencies GSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK's commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site. Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf..... click apply for full job details
Sep 22, 2022
Full time
Site Name: UK - Hertfordshire - Stevenage Posted Date: Sep 6 2022 Senior Scientist, Materials Science Materials Science provides holistic understanding of how structure influences particle and powder properties to design a particle process which optimises drug product processing and performance. As projects advance through development, materials scientists support project teams by performing laboratory studies, analysing data, from lead optimization up to and including the transfer and industrialization of manufacturing processes to commercial facilities. Your role will be focused on the characterisation of drug substances to support the design, selection and progression of all new drug products developed within GSK's Pharmaceutical portfolio. This will be based on generation of physical properties, biopharmaceutics and materials science understanding and knowledge created using a range of solid-state physical characterisation, structural analysis and in-vitro analytical methods. Here at our pioneering R&D Stevenage site we have a fantastic opportunity for a position in our Materials Science Team. It is predominantly lab-based and may require some travel to our other R&D site in Ware, Hertfordshire. In this role you will Design, perform and may lead physical properties analysis of drug substance and drug product when required using a range of analytical techniques, including XRPD, GVS, Raman, DSC, TGA, Optical Microscopy Design, execute and may lead work packages to relate the physical properties of drug substance and drug product to structure, performance and efficacy (e.g. solid form landscape, particle size and shape, hygroscopicity, thermal stability and bulk properties) Develop plans and execute laboratory experiments for in-vitro biorelevant measurements of a drug substance or formulation (e.g. kinetic solubility, dissolution, Intrinsic Dissolution Rate, particle imaging and permeability) across multiple projects to generate data to inform R&D decision making Work in collaboration with partners (e.g. Crystallographers, Pharmaceutical Development, Biopharmaceutics, CMC Analytical) to obtain inputs for predicting and modelling in-vivo product performance and/or aid structural understandings from physical properties Participate in method validation and technology transfer activities to GSC, other parts of R&D and partner CMO's (as appropriate for the grade) Contribute to the strategy and decision making for projects through analysis, reporting and review of data (over oversight of data from CRO's) as appropriate for the grade Ensure appropriate quality activities are performed throughout development including authoring of analytical test results. May have leadership responsibilities in quality areas. Work effectively and collaboratively on multi-disciplinary medicine development teams Confident in data management and some data interpretation, record results effectively and communicate results in technical reports Comply with local regulatory and data integrity requirements, including cGMP and GSK policies and procedures, with high quality and attention to one's own safety Why you? Qualifications & Skills: We are looking for professionals with these required skills to achieve our goals: PhD or BSc/MSc and approximately 5 years industrial experience. Effective oral and written communication skills Some years of proven working knowledge of physical and analytical chemistry Good time management and team-working skills Some years of experience in a lab-based setting Working knowledge of pharmaceutical development process Working knowledge of relating physical properties to structure and performance of drug substance and drug product Preferred Qualifications & Skills: If you have the following characteristics, it would be a plus: Some awareness of in in-vitro biorelevant measurements (e.g. solubility/dissolution, Intrinsic Dissolution Rate, transfer models) for oral biopharmaceutics Experience in solid state characterisation (e.g. XRPD, thermal analysis, microscopy, imaging, Scientific knowledge and understanding of the anatomy/physiology of body, absorption, distribution & metabolism, and integration of biopharmaceutics with formulation design across dosage forms. Why GSK? Uniting science, technology and talent to get ahead of disease together GSK is a global biopharma company with a special purpose - to unite science, technology and talent to get ahead of disease together - so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns - as an organisation where people can thrive. Getting ahead means preventing disease as well as treating it, and we aim to impact the health of 2.5 billion people around the world in the next 10 years. Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it's also about making GSK a place where people can thrive. We want GSK to be a place where people feel inspired, encouraged and challenged to be the best they can be. A place where they can be themselves - feeling welcome, valued and included. Where they can keep growing and look after their wellbeing.So, if you share our ambition, join us at this exciting moment in our journey to get Ahead Together. Find out more: Annual Report 2021 Closing Date for Applications: Friday 23rd September 2022 (COB) Please take a copy of the Job Description, as this will not be available post closure of the advert. When applying for this role, please use the 'cover letter' of the online application or your CV to describe how you meet the competencies for this role, as outlined in the job requirements above. The information that you have provided in your cover letter and CV will be used to assess your application. During the course of your application you will be requested to complete voluntary information which will be used in monitoring the effectiveness of our equality and diversity policies. Your information will be treated as confidential and will not be used in any part of the selection process. If you require a reasonable adjustment to the application / selection process to enable you to demonstrate your ability to perform the job requirements, please contact . This will help us to understand any modifications we may need to make to support you throughout our selection process. LI-GSK As a company driven by our values of Patient focus, Transparency, Respect and Integrity, we know inclusion and diversity are essential for us to be able to succeed. We want all our colleagues to thrive at GSK bringing their unique experiences, ensuring they feel good and to keep growing their careers. As a candidate for a role, we want you to feel the same way. As an Equal Opportunity Employer, we are open to all talent. In the US, we also adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to neurodiversity, race/ethnicity, colour, national origin, religion, gender, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class ( US only). We believe in an agile working culture for all our roles. If flexibility is important to you, we encourage you to explore with our hiring team what the opportunities are. Please don't hesitate to contact us if you'd like to discuss any adjustments to our process which might help you demonstrate your strengths and capabilities. You can either call us on , or send an email As you apply, we will ask you to share some personal information which is entirely voluntary. We want to have an opportunity to consider a diverse pool of qualified candidates and this information will assist us in meeting that objective and in understanding how well we are doing against our inclusion and diversity ambitions. We would really appreciate it if you could take a few moments to complete it. Rest assured, Hiring Managers do not have access to this information and we will treat your information confidentially. Important notice to Employment businesses/ Agencies GSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK's commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site. Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf..... click apply for full job details
This is an excellent opportunity for a student with an interest in fuel cells or electrolysers to develop personally and professionally within a successful and growing business. Working within the Energy Materials department they will be directly involved in developing the next generation of Solid Oxide Cell technology. Suitable candidates Students currently studying for a first degree in materials science/engineering, chemistry/chemical engineering, physics, or similar degrees offering a 12 month 'sandwich' course. Candidates should have a demonstrable interest in electrochemical devices and the 'clean energy sector' and be prepared to work hard to improve their knowledge of materials, ceramics, ceramics processing and Solid Oxide Cells. They should also be comfortable, competent, and proficient in working in a laboratory environment and completing tasks requiring a moderate to high level of dexterity. Mentoring and development The student will have an appointed mentor/industrial supervisor of at least senior scientist level, who will be responsible for their development during the placement period and liaising with the academic supervisor. There will be regular meetings, in addition to day-to-day supervision, to assess and guide the student's personal development. Training will be provided in all the characterisation methods and processes required to complete the role described below, as well as specific training for project activities as required. Further training to enhance rigour in data analysis using statistical tools will be also be provided. An induction program will be followed in the first few months covering different business functions including (at least): Health, Safety and the Environment, Intellectual Property, Commercial and Engineering. The student will also be privy to the regular internal company updates, which touch on significant developments from department such as manufacturing and engineering as well as important commercial developments. Role The successful candidate will form part of the Energy Materials R&D team and will split their time 50:50 between a dedicated year-long student project and supporting the cutting edge analysis of Solid Oxide Fuel Cells and Electrolyser Cells. The project work will explore brand new and exciting solid oxide materials and/or processes. Additionally, by supporting our experienced scientists in materials and process development you will be directly advancing development of the next generation of Solid Oxide Cells. These tasks will both include significant practical lab work, experimental design, detailed data analysis, collaboration with colleagues and experts across the business, and are a fantastic opportunity to get first-hand practical exposure to cutting edge science in a leading UK clean-tech company. 50% Student Project - Bespoke project exploring cutting edge Solid Oxide materials and/or processes (supported by Senior Scientist(s) in EM team) 50% Support EM Development - Perform measurements, experiments, trials and/or syntheses to support R&D activities within the Energy Materials department (supported by Senior Scientist(s) in EM team) Within the Energy Materials team, the placement student will be involved in most aspects of the . These may include: Planning activities on a weekly basis. Post-test inspection of components (optical microscopy, bench tests). Preparing samples for SEM analysis (cutting, mounting, grinding, polishing). SEM imaging and elemental analysis (EDX/WDX). Analysis of ceramic powder samples (XRD, BET, dilatometry, TGA). Materials processing (synthesis, furnaces) Rheological characterisation Deposition processes Preparation of reports and explaining results to the request originator. Project work will be undertaken in an area of relevance to the cell development team and will have the potential to affect the product development. Typically, the project will involve the development of cell materials and/or processes or cell characterisation methods. Working under the supervision of a senior scientist within the development team the student is likely to be involved in the following type of activities: Thoroughly planning the development work, developing clear objectives, deliverables and a realistic timing plan. Creating well thought out experiments using the 'Design of Experiments' statistical tools. Creating and reviewing Risk Assessments and COSHH assessments. Taking a hands-on role in development activities e.g. screen print ink development. Organising any required further cell processing and testing activities. Analysing any characterisation and testing data and reporting on statistically relevant results. Providing regular project updates to the technical and project review team. Presenting the project results to a wider company audience at the end of the placement and during as required. Knowledge, qualification, skills Required Education: studying materials science, chemistry, physics, chemical engineering, or a related degree. A diligent and fast learner with very good attention to detail. Self-starting attitude and willingness to 'get stuck in' with practical aspects of the role. Good communication skills. Desirable Basic understanding of fuel cell/battery operation and/or electrochemistry ]]
May 28, 2022
Full time
This is an excellent opportunity for a student with an interest in fuel cells or electrolysers to develop personally and professionally within a successful and growing business. Working within the Energy Materials department they will be directly involved in developing the next generation of Solid Oxide Cell technology. Suitable candidates Students currently studying for a first degree in materials science/engineering, chemistry/chemical engineering, physics, or similar degrees offering a 12 month 'sandwich' course. Candidates should have a demonstrable interest in electrochemical devices and the 'clean energy sector' and be prepared to work hard to improve their knowledge of materials, ceramics, ceramics processing and Solid Oxide Cells. They should also be comfortable, competent, and proficient in working in a laboratory environment and completing tasks requiring a moderate to high level of dexterity. Mentoring and development The student will have an appointed mentor/industrial supervisor of at least senior scientist level, who will be responsible for their development during the placement period and liaising with the academic supervisor. There will be regular meetings, in addition to day-to-day supervision, to assess and guide the student's personal development. Training will be provided in all the characterisation methods and processes required to complete the role described below, as well as specific training for project activities as required. Further training to enhance rigour in data analysis using statistical tools will be also be provided. An induction program will be followed in the first few months covering different business functions including (at least): Health, Safety and the Environment, Intellectual Property, Commercial and Engineering. The student will also be privy to the regular internal company updates, which touch on significant developments from department such as manufacturing and engineering as well as important commercial developments. Role The successful candidate will form part of the Energy Materials R&D team and will split their time 50:50 between a dedicated year-long student project and supporting the cutting edge analysis of Solid Oxide Fuel Cells and Electrolyser Cells. The project work will explore brand new and exciting solid oxide materials and/or processes. Additionally, by supporting our experienced scientists in materials and process development you will be directly advancing development of the next generation of Solid Oxide Cells. These tasks will both include significant practical lab work, experimental design, detailed data analysis, collaboration with colleagues and experts across the business, and are a fantastic opportunity to get first-hand practical exposure to cutting edge science in a leading UK clean-tech company. 50% Student Project - Bespoke project exploring cutting edge Solid Oxide materials and/or processes (supported by Senior Scientist(s) in EM team) 50% Support EM Development - Perform measurements, experiments, trials and/or syntheses to support R&D activities within the Energy Materials department (supported by Senior Scientist(s) in EM team) Within the Energy Materials team, the placement student will be involved in most aspects of the . These may include: Planning activities on a weekly basis. Post-test inspection of components (optical microscopy, bench tests). Preparing samples for SEM analysis (cutting, mounting, grinding, polishing). SEM imaging and elemental analysis (EDX/WDX). Analysis of ceramic powder samples (XRD, BET, dilatometry, TGA). Materials processing (synthesis, furnaces) Rheological characterisation Deposition processes Preparation of reports and explaining results to the request originator. Project work will be undertaken in an area of relevance to the cell development team and will have the potential to affect the product development. Typically, the project will involve the development of cell materials and/or processes or cell characterisation methods. Working under the supervision of a senior scientist within the development team the student is likely to be involved in the following type of activities: Thoroughly planning the development work, developing clear objectives, deliverables and a realistic timing plan. Creating well thought out experiments using the 'Design of Experiments' statistical tools. Creating and reviewing Risk Assessments and COSHH assessments. Taking a hands-on role in development activities e.g. screen print ink development. Organising any required further cell processing and testing activities. Analysing any characterisation and testing data and reporting on statistically relevant results. Providing regular project updates to the technical and project review team. Presenting the project results to a wider company audience at the end of the placement and during as required. Knowledge, qualification, skills Required Education: studying materials science, chemistry, physics, chemical engineering, or a related degree. A diligent and fast learner with very good attention to detail. Self-starting attitude and willingness to 'get stuck in' with practical aspects of the role. Good communication skills. Desirable Basic understanding of fuel cell/battery operation and/or electrochemistry ]]
Computational Biology expert leading R&D for cutting-edge drug discovery start-up in London. Neuroscience & AI Your new company Hays Life Sciences are exclusively partnered with Esya Labs, a diverse, female-led company with an inclusive atmosphere focused on developing precise and cost-effective non-invasive diagnostic tools for diagnosing neurodegenerative diseases well before the disease symptoms manifest physically, using a breakthrough cell scanning technology. We use a cutting-edge DNA-based nanotechnology, which is supported by 11 patents and has been reported in several peer-reviewed scientific publications in high-impact journals. Our pioneering technology allows us image and analyse intracellular chemical signatures to: 1) Build a toolkit of biomarkers for the diagnosis of Alzheimer's and other neuro-degenerative diseases. 2) Measure and monitor the progression of diseases of interest. 3) Assist drug development efforts by quantifying patients' responses to various treatments and pre-assessing patient suitability for treatments. \"Esya's technology is truly revolutionary. Research results have been supporting the potential for this to be a real game changer in Alzheimer's diagnostics.\" Professor Jack Szostak, Nobel Laureate Your new role ESYA LABS is building a dynamic team that is passionate about translating new discoveries at the nexus of biotechnology, cell biology, imaging, and neurology. Driven by recent commercial partnerships with several world-leading pharmaceutical companies, including Novartis, we are expanding our research capabilities in our newly established London laboratory and are seeking an experienced Computational Biologist to join our growing research team. This role is an exciting opportunity for a high performing candidate with extensive multi-omics experience to join a ground-breaking start-up in London and make a significant impact on the company's development as they go into a rapid growth phase. You will lead the development of Esya's neuromultiomics platform underlying our diagnostics products, developing cutting edge solutions at the intersection of machine learning, genetic sequencing technology, biological data, and distributed systems. These contributions will drive our mission to diagnose neurocognitive impairments at its most actionable and early stages. As part of an interdisciplinary R&D effort, you will help us recruit and build a team of computational biologists, machine learning scientists and software engineers. Core Responsibilities * Lead the development of Esya's neuromultiomics platform which will sit at the core of our company: * Develop a set of scalable ML-driven diagnostic algorithms that enable our product development, aimed at maximising diagnostic accuracy, specificity, and sensitivity. * Develop the infrastructure to enable the selection, acquisition, QCing, normalization, and processing of multi-omics data. * Select and integrate relevant public data (from sources such as academia and publicly available databases) with internal data sets * Build for significant growth and scaling challenges as we transition from research to product development, ensuring our platform maintains reliability and scalability as it grows * Liaise with internal stakeholders to identify biological data requirements as well as potential resource\/data gaps and develop strategies to mitigate these * Interface and network with senior scientists in Pharma, Biotech, and Academia * Work closely with biological scientists to understand research needs and engineer robust and reproducible data pipelines that enable cutting edge liquid biopsy research * Develop software and workflows that support a long-term vision for product development driven by bioinformatics and data science research * Design, optimise and implement computational strategy What you'll need to succeed * Significant experience with bioinformatics software packages and tools, as well as related infrastructure * Strong Machine Learning or Deep Learning skills applied to biological data; experience with neural nets would be a distinct advantage, as would a history of developing \/ rapid prototyping models, algorithms or methods * Familiarity with libraries such as numpy, scipy, pandas, Keras, scikit-learn, etc or platforms such as Tensorflow * Track record of building and managing a highly effective team of computational scientists. * Robust history of delivering major technical projects or analyses, including experience in a technical leadership role. * Knowledge of the neuroscience domain is critical, with experience in neurodegenerative diseases, such as Alzheimer's or Parkinson's a strong advantage * Strong computational and programming skills, in Python or R, including thorough experience with large scale systems and user bases. Experience in applying statistical methods and algorithms to large-scale biological datasets. * Fundamental understanding of bioinformatics, molecular biology, and familiarity with regulatory processes. * Hands-on experience analysing large scale omics data sets, eg genomics, epigenomics, proteomics (including mass spectrometry), transcriptomics (RNA-seq), Hi-C, ATAC-seq, etc. Experience of working with multi-omics data and\/or immunodetection assays would be an advantage for this role. * Demonstrated ability to partner with laboratory and computational scientists and engineers to translate scientific roadmaps into concrete products, as cross-functional collaboration is integral to the role. * A BSc \/ MSc (or equivalent experience) in a relevant field such as computational biology, statistics, bioinformatics, computer science, biology or similar, with a strong preference for a PhD. What you'll get in return * Fantastic chance to join one of the most exciting companies in the neuroscience space and make a significant impact on the next generation of precision diagnostics * Unique learning opportunity in neurology and the pathways of neurodegenerative diseases * Work with leading researchers in molecular biology * A competitive salary, reviewed annually, combined with an attractive bonus structure * Flexible working hours (core hours 10-4, with a 40-hour working week) * Ongoing professional development support and a significant opportunity to grow our company What you need to do now If you're interested in this role, click 'apply now' to forward an up-to-date copy of your CV, or call on . Keywords: bioinformatics, bioinformatician, computational, biology, machine, deep, learning, artificial, intelligence, CNN, neural, net, algorithm, model, Tensorflow, Keras, scipy, numpy, drug, discovery, development, biomarker, assay, research, development, leadership, manager, Director, diagnostics, neuroscience, neurodegenerative, disease, Alzheimer, Parkinson, genetics, genomics, omic, NGS,
Dec 06, 2021
Full time
Computational Biology expert leading R&D for cutting-edge drug discovery start-up in London. Neuroscience & AI Your new company Hays Life Sciences are exclusively partnered with Esya Labs, a diverse, female-led company with an inclusive atmosphere focused on developing precise and cost-effective non-invasive diagnostic tools for diagnosing neurodegenerative diseases well before the disease symptoms manifest physically, using a breakthrough cell scanning technology. We use a cutting-edge DNA-based nanotechnology, which is supported by 11 patents and has been reported in several peer-reviewed scientific publications in high-impact journals. Our pioneering technology allows us image and analyse intracellular chemical signatures to: 1) Build a toolkit of biomarkers for the diagnosis of Alzheimer's and other neuro-degenerative diseases. 2) Measure and monitor the progression of diseases of interest. 3) Assist drug development efforts by quantifying patients' responses to various treatments and pre-assessing patient suitability for treatments. \"Esya's technology is truly revolutionary. Research results have been supporting the potential for this to be a real game changer in Alzheimer's diagnostics.\" Professor Jack Szostak, Nobel Laureate Your new role ESYA LABS is building a dynamic team that is passionate about translating new discoveries at the nexus of biotechnology, cell biology, imaging, and neurology. Driven by recent commercial partnerships with several world-leading pharmaceutical companies, including Novartis, we are expanding our research capabilities in our newly established London laboratory and are seeking an experienced Computational Biologist to join our growing research team. This role is an exciting opportunity for a high performing candidate with extensive multi-omics experience to join a ground-breaking start-up in London and make a significant impact on the company's development as they go into a rapid growth phase. You will lead the development of Esya's neuromultiomics platform underlying our diagnostics products, developing cutting edge solutions at the intersection of machine learning, genetic sequencing technology, biological data, and distributed systems. These contributions will drive our mission to diagnose neurocognitive impairments at its most actionable and early stages. As part of an interdisciplinary R&D effort, you will help us recruit and build a team of computational biologists, machine learning scientists and software engineers. Core Responsibilities * Lead the development of Esya's neuromultiomics platform which will sit at the core of our company: * Develop a set of scalable ML-driven diagnostic algorithms that enable our product development, aimed at maximising diagnostic accuracy, specificity, and sensitivity. * Develop the infrastructure to enable the selection, acquisition, QCing, normalization, and processing of multi-omics data. * Select and integrate relevant public data (from sources such as academia and publicly available databases) with internal data sets * Build for significant growth and scaling challenges as we transition from research to product development, ensuring our platform maintains reliability and scalability as it grows * Liaise with internal stakeholders to identify biological data requirements as well as potential resource\/data gaps and develop strategies to mitigate these * Interface and network with senior scientists in Pharma, Biotech, and Academia * Work closely with biological scientists to understand research needs and engineer robust and reproducible data pipelines that enable cutting edge liquid biopsy research * Develop software and workflows that support a long-term vision for product development driven by bioinformatics and data science research * Design, optimise and implement computational strategy What you'll need to succeed * Significant experience with bioinformatics software packages and tools, as well as related infrastructure * Strong Machine Learning or Deep Learning skills applied to biological data; experience with neural nets would be a distinct advantage, as would a history of developing \/ rapid prototyping models, algorithms or methods * Familiarity with libraries such as numpy, scipy, pandas, Keras, scikit-learn, etc or platforms such as Tensorflow * Track record of building and managing a highly effective team of computational scientists. * Robust history of delivering major technical projects or analyses, including experience in a technical leadership role. * Knowledge of the neuroscience domain is critical, with experience in neurodegenerative diseases, such as Alzheimer's or Parkinson's a strong advantage * Strong computational and programming skills, in Python or R, including thorough experience with large scale systems and user bases. Experience in applying statistical methods and algorithms to large-scale biological datasets. * Fundamental understanding of bioinformatics, molecular biology, and familiarity with regulatory processes. * Hands-on experience analysing large scale omics data sets, eg genomics, epigenomics, proteomics (including mass spectrometry), transcriptomics (RNA-seq), Hi-C, ATAC-seq, etc. Experience of working with multi-omics data and\/or immunodetection assays would be an advantage for this role. * Demonstrated ability to partner with laboratory and computational scientists and engineers to translate scientific roadmaps into concrete products, as cross-functional collaboration is integral to the role. * A BSc \/ MSc (or equivalent experience) in a relevant field such as computational biology, statistics, bioinformatics, computer science, biology or similar, with a strong preference for a PhD. What you'll get in return * Fantastic chance to join one of the most exciting companies in the neuroscience space and make a significant impact on the next generation of precision diagnostics * Unique learning opportunity in neurology and the pathways of neurodegenerative diseases * Work with leading researchers in molecular biology * A competitive salary, reviewed annually, combined with an attractive bonus structure * Flexible working hours (core hours 10-4, with a 40-hour working week) * Ongoing professional development support and a significant opportunity to grow our company What you need to do now If you're interested in this role, click 'apply now' to forward an up-to-date copy of your CV, or call on . Keywords: bioinformatics, bioinformatician, computational, biology, machine, deep, learning, artificial, intelligence, CNN, neural, net, algorithm, model, Tensorflow, Keras, scipy, numpy, drug, discovery, development, biomarker, assay, research, development, leadership, manager, Director, diagnostics, neuroscience, neurodegenerative, disease, Alzheimer, Parkinson, genetics, genomics, omic, NGS,
