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Field Service Engineer Apprentice - Manchester site-based page is loaded Field Service Engineer Apprentice - Manchester site-based Apply remote type Office Based locations MAN time type Full time posted on Posted Yesterday job requisition id R-22242 Join us in pioneering breakthroughs in healthcare. For everyone. Everywhere. Sustainably. Our inspiring and caring environment forms a global community that celebrates diversity and individuality. We encourage you to step beyond your comfort zone, offering resources and flexibility to foster your professional and personal growth, all while valuing your unique contributions. Are you due to finish school or college and considering a career inEngineering?How would you like to undertake anApprenticeshipwith a company that is a global leader in radiation therapy, medical imaging, laboratory diagnostics and medical information technology? As a Proton Therapy Field Service Engineer Apprentice at Varian (a Siemens Healthineers Company), you will be an integral part of our site-based engineering team at The Christie in Manchester. Your responsibilities will include monitoring, repairing, and maintaining our Proton Beam Therapy medical systems. You'll provide essential technical service support to our customers, working within a global service team, all the while earning Level 3 accredited qualifications. What to Expect: Attend Macclesfield College to work towards achieving a Level 3 in Mechatronic Engineering Work at The Christie Hospital, Withington, Manchester, as well as Varian maufacturing sites and training centres in Europe. Gain hands-on experience diagnosing and repairing complex mechanical and electrical issues on high-tech medical products. Upon completion of the apprenticeship and with a good training record, you will have the opportunity to apply for a permanent full-time position as a Field Service Engineer with opportunities for further education and product training. What We're Looking For: A keen interest in technology and a desire to make a positive impact in healthcare. Ability to analyse and troubleshoot technical issues. Collaborative mindset with effective communication skills. Willingness to learn and adapt to new challenges in a dynamic environment. Prepared to participate in a shift pattern to cover extended hours () at times. What We Offer: A four-year program designed to equip you with the knowledge and skills needed to excel in the role. Work alongside industry experts in real-world settings, ensuring a practical understanding of our cutting-edge technology. Attain a Level 3 qualification to enhance your professional standing. Opportunities for progression and development within Varian and Siemens Healthineers after successful completion of the apprenticeship. Benefits: Starting salary £15,000 - £19,950 (age dependant) Shift allowance for when shift working hours commence To apply for this Field Service Engineer Apprentice role, you will need at least four GCSEs at grade 4 (or C) or above, including English Language and Maths. You will also need to meet the UK Government's Apprenticeship eligibility criteria: Have been a UK/EU/EAA resident for the past three years or more prior to starting the course Have left full time education when the apprenticeship you are applying for is due to start Please note we review applications on a rolling basis so this role may close early - please apply now to avoid disappointment! Who we are : We are a team of more than 73,000 highly dedicated Healthineers in more than 70 countries. As a leader in medical technology, we constantly push the boundaries to create better outcomes and experiences for patients, no matter where they live or what health issues they are facing. Our portfolio is crucial for clinical decision-making and treatment pathways. How we work : When you join Siemens Healthineers, you become one in a global team of scientists, clinicians, developers, researchers, professionals, and skilled specialists, who believe in each individual's potential to contribute with diverse ideas. We are from different backgrounds, cultures, religions, political and/or sexual orientations, and work together, to fight the world's most threatening diseases and enable access to care, united by one purpose: to pioneer breakthroughs in healthcare. For everyone. Everywhere. Sustainably. To find out more about Healthineers' specific businesses, please visit our company page here . As an equal opportunity employer, we welcome applications from individuals with disabilities. Data Privacy : We care about your data privacy and take compliance with GDPR as well as other data protection legislation seriously. For this reason, we ask you not to send us your CV or resume by email. We ask instead that you create a profile where you can upload your CV. Setting up a profile also lets us know you are interested in career opportunities with us and makes it easy for us to send you an alert when relevant positions become open. Register here to get started. Beware of Job Scams: Please beware of potentially fraudulent job postings or suspicious recruiting activity by persons that are currently posing as Siemens Healthineers recruiters/employees. These scammers may attempt to collect your confidential personal or financial information. If you are concerned that an offer of employment with Siemens Healthineers might be a scam or that the recruiter is not legitimate, please verify by searching for the posting on the Siemens Healthineers career site. To all recruitment agencies : Siemens Healthineers does not accept agency resumes. Please do not forward resumes to our jobs alias, employees, or any other company location. Siemens Healthineers is not responsible for any fees related to unsolicited resumes. As an equal opportunity employer, we welcome applications from individuals with disabilities. We are a team of 72,000 highly dedicated employees across more than 70 countries passionately pushing the boundaries of what's possible in healthcare to help improve people's lives around the world. As a leader in the industry, we aspire to create better outcomes and experiences for patients no matter where they live or what health issues they are facing. Our portfolio, spanning from in-vitro and in-vivo diagnostics to image-guided therapy and innovative cancer care, is crucial for clinical decision-making and treatment pathways. Our culture: We are part of an incredible community of scientists, clinicians, developers, researchers, professionals, and skilled specialists pushing the boundaries of what's possible, to improve people's lives around the world. We embrace a culture of inclusivity in which the power and potential of every individual can be unleashed. We spark ideas that lead to positive impact and continued success.

About AQEMIA AQEMIA is a next-gen pharmatech company generating one of the world's fastest-growing drug discovery pipeline. Our mission is to design fast innovative drug candidates for dozens of critical diseases, such as immuno-oncology. Our unique approach leverages quantum-inspired physics algorithms to power generative AI in designing novel drug candidates-without relying on experimental data. We already delivered several drug discovery successes within our internal pipeline and through collaborations with pharmaceutical companies. Our most advanced programs are currently in vivo optimization. Role Overview We are seeking a Senior Manager to lead our Physics Application Science Team. This team is responsible for integrating and optimising physics-based computational methods to enhance our drug discovery efforts. This role is critical in ensuring that physics-based computational methods effectively contribute to our hit discovery and lead optimisation strategies, ultimately accelerating the identification of novel drug candidates. The ideal candidate will have both strong leadership abilities to manage a team of scientists and deep technical expertise in Statistical Mechanics and Computational Chemistry. Key Responsibilities Lead, manage, and mentor a team of scientists specializing in physics-based computational methods. Define and execute strategic initiatives to integrate physics-based models including our in-house state-of-the-art solvation free energy algorithm into the drug discovery workflow. Provide technical leadership in Statistical Mechanics, Molecular Dynamics, Free Energy Calculations, or Computational Chemistry. Collaborate closely with cross-functional teams, including AI researchers, medicinal chemists, and computational chemists, to align computational strategies with drug discovery objectives. Drive innovation by identifying and implementing emerging computational approaches to improve hit discovery and lead optimization. Ensure the team delivers high-quality scientific results on time, balancing research innovation with practical impact. Foster a collaborative and high-performing team culture, ensuring continuous growth and development of team members. Communicate scientific insights and strategic recommendations to senior leadership and key stakeholders. Qualifications PhD in Statistical Mechanics, Computational Chemistry, Biophysics, or a related field. Senior experience in computational drug discovery, with at least 3 years in a leadership role. Strong expertise in physics-based computational methods, such as Molecular Dynamics, Free Energy Perturbation (FEP), or Enhanced Sampling Techniques with an emphasis on solvation free energy methods (using density functional theory, PBSA, GBSA for instance). Proven ability to manage, mentor, and develop a team of scientists in a high-performance environment. Strong project management skills with the ability to prioritize tasks and drive results. Excellent communication skills to engage with interdisciplinary teams and senior stakeholders. Familiarity with commercial drug discovery suites (e.g. Schrödinger and OpenEye), open source molecular dynamics packages (OpenMM, AMBER, GROMACS, NAMD) and chemoinformatics tools (e.g. RDKit and OpenBabel). Nice to have: Experience in machine learning applications for physics-based modeling. Background in high-performance computing (HPC) and cloud-based simulations. Track record of scientific publications and contributions to the computational drug discovery community. Preferred Mindset Ability to set a technical vision for the team and align it with company objectives. Collaborative Leader: Thrives in an interdisciplinary environment and values teamwork. Pragmatic and Impact-Driven: Balances scientific rigor with real-world application. Growth-Oriented: Invests in the development of team members and fosters a culture of continuous learning. Passionate about pushing the boundaries of physics-based drug discovery. Aqemia's Recruitment team leads all recruitment activities for the company. We will not recognise any notional ownership recruitment companies claim over candidates presented directly to hiring managers without our Recruitment team's consent. Unsolicited resumes sent to us from recruiters do not constitute any type of relationship between the recruiter and Aqemia, and we will not be obligated to pay fees should we hire from those resumes. Why Join Us ? At AQEMIA, we work for a mission: joining us means having your own impact on changing the way drugs are discovered, and helping to shape thedirectionof our fast-growing company and team. Expanding Drug Discovery Pipeline : Focused on critical therapeutic areas like Oncology, CNS, Immuno-inflammation with in vivo proof of concept/patent stage programs. Collaborations with top Pharma, including a $140M Sanofi deal. Interdisciplinary Team: brilliant talent from tech and life sciences. DeepTech Recognition: Part of French Tech 120 and France 2030. Prime Location : Based in central Paris and London (King's Cross) with the possibility of 2 remote days per week. International Environment : The work language is English - relocation support and French lessons granted if needed. Strong Financial Backing : $100M raised from leading European and International investors

Company Information All the health information we need is within us. Just below the skin. SAVA is redefining the way people interact with their health by developing the most advanced biosensing technology science has to offer, capable of accessing bodily information in a painless, real-time and affordable way. Description We are seeking an exceptional Senior Scientist to join our Process Chemistry Team within the Biosensing and In Vivo Performance Department. This team is critical to sensor development, focusing on process optimisation to seamlessly integrate raw materials (synthesis) and sensor manufacturing to build a product which will have an impact worldwide. This integration is essential for enhancing device performance and scaling up from small-scale R&D to high-throughput manufacturing processes. The ideal candidate will have: demonstrated excellence in process science, chemistry, or biotechnology; a solid understanding of designing characterisation trials to assess parameters impacting sensor performance and, ultimately, the overall functionality of our biosensors; and a relentless drive to raise the bar and redefine boundaries. What You'll Do Work within the Process Chemistry Team to develop and characterise the sensor build process to optimise the materials and process steps involved in manufacturing a minimally invasive biosensor platform. Collaborate with the Chemistry, Process, Manufacturing and Engineering teams to implement material and process changes for optimisation of sensor performance. Develop new protocols to further the understanding of various aspects of materials and processes used in sensor manufacture and performance. Develop explorative trials, including DoE trials, that investigate material and process parameters to optimise sensor performance. Utilise analytical techniques to understand how material characteristics impact sensor manufacturing and device function. Coordinate and complete in vitro testing to determine the performance of novel candidate materials used in sensor manufacture. Generate, analyse and report data to the team and wider company, verbally and in writing. Maintain detailed, up to date records of experiments and data analysis. Research and source new equipment to support critical research areas. Liaise with internal and external stakeholders to coordinate projects, managing deadlines and requirements in parallel to advance device development. What We're Looking For BSc degree or above, plus lab experience in a relevant discipline (e.g., biomedical science, bioengineering, materials science) working with process development and characterisation. A multidisciplinary background is advantageous. The candidate will be expected to work cross-functionally with teams including Biosensing, Synthetic Chemistry, Manufacturing, Data and Engineering, which may include: process characterisation, new material investigation, medical device manufacture, sterilisation, in vitro testing, enzyme stability and activity, microscopy (Keyence experience), operation of inkjet systems. Proactive not reactive, highly organised and adaptable. The desire to get hands-on in the lab every day, the ability and ambition to learn new skills and techniques quickly, manage variable workstreams at a time and to deal with the fast pace of a startup environment. Excellent knowledge and experience in experimental design, including DoEs. Presentation and communication of data to both technical and non-technical audiences with active participation in meetings and discussions. Willingness to work hard when needed and to go above and beyond, because you care about making a difference. Bonus Points Experience in lab and manufacturing environments (preferred clean room experience but not essential). Experience with and knowledge of biosensors or medical devices Experience in the operation of inkjet systems and larger robotics (at operator level following protocol). Skilled with data analysis and visualisation software and tools (e.g., JMP, python, R, MATLAB). Biosensor or Medical Device Industry experience, working on process characterisation and optimisation. Why Sava? This is a high-ownership, high-responsibility role in a company that's building something complex, meaningful, and fast. The expectations are high, the learning curve is steep, and the work is often messy, but the impact is real. We don't have room for egos or passengers. What we do have is a team of thoughtful, driven, and mission-aligned people who are committed to building something better, and doing it with urgency and integrity.

Job Description Summary We are seeking a highly motivated scientist to contribute to our mission to deliver transformative new therapies for patients with kidney diseases Disease Area X (DAx) at the Novartis BioMedical Research (BR) facility located in Cambridge, MA. In this position, you will contribute to research programs delineating key mechanisms involved in kidney disease progression, playing a crucial role in progressing new targets toward drug discovery through the independent development and execution of novel cell-based assays and complex cellular systems in order to improve patient outcomes. Job Description Internal Job Title: Senior Scientist I/Senior Scientist II Position Location: On-site, Cambridge, MA About the Role: We are seeking a highly motivated scientist to contribute to our mission to deliver transformative new therapies for patients with kidney diseases Disease Area X (DAx) at the Novartis BioMedical Research (BR) facility located in Cambridge, MA. In this position, you will contribute to research programs delineating key mechanisms involved in kidney disease progression, playing a crucial role in progressing new targets toward drug discovery through the independent development and execution of novel cell-based assays and complex cellular systems in order to improve patient outcomes. Key responsibilities: Independently design, develop, execute experiments generating high-quality data and results to enable decision-making for projects in the DAx portfolio. Evaluate results and interpret data from different sources, draw relevant conclusions, document, and present data in line with project needs and timelines. Establish, optimize, and validate novel in vitro models, assays, and readouts for kidney diseases. Set a strong example of leadership from the bench by actively collaborating with other associates, sharing knowledge and expertise, and mentoring junior lab members in scientific and technical capabilities. Collaborate with multidisciplinary teams within DAx and across Biomedical Research. Essential requirements: BS or MS in cell biology, molecular biology, immunology, or other life science field with a minimum of 4 years of related post-graduate laboratory experience in an industrial drug discovery setting. Recent PhD graduates with kidney experience will also be considered. Background and proficiency in primary cell culture and cell-based assay development. Experience in a broad range of molecular biology techniques including qPCR, Western Blot, ELISA, microscopy, and flow cytometry. Demonstrated ability to work independently and as part of a collaborative, interdisciplinary team of biologists, computational scientists, and translational research/medical scientists. Strong written and verbal communication skills, organizational skills, and excellent attention to detail. Desirable Requirements: Experience in cell-based and biochemical assay development (scaling, high throughput screening, etc.) in an industrial setting. Experience in co-culture (or complex cellular) models, and/or ex vivo systems to model kidney disease. The salary for this position is expected to range between: Senior Scientist I: $85,400 and $158,600 per year Senior Scientist II: $97,600 and $174,200 per year. The final salary offered is determined based on factors like, but not limited to, relevant skills and experience, and upon joining Novartis will be reviewed periodically. Novartis may change the published salary range based on company and market factors. Your compensation will include a performance-based cash incentive and, depending on the level of the role, eligibility to be considered for annual equity awards. US-based eligible employees will receive a comprehensive benefits package that includes health, life and disability benefits, a 401(k) with company contribution and match, and a variety of other benefits. In addition, employees are eligible for a generous time off package including vacation, personal days, holidays and other leaves. To learn more about the culture, rewards and benefits we offer our people click here . EEO Statement: The Novartis Group of Companies are Equal Opportunity Employers. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, sex, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. Accessibility and reasonable accommodations The Novartis Group of Companies are committed to working with and providing reasonable accommodation to individuals with disabilities. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application process, or to perform the essential functions of a position, please send an e-mail to or call + and let us know the nature of your request and your contact information. Please include the job requisition number in your message. Salary Range $85,400.00 - $158,600.00 Skills Desired Analytical Skill, Analytical Skill, Analytical Thinking, Chemical Biology, Chemistry, Clinical Research, Clinical Trials, Collaboration, Communication Skills, Curiosity, Data, Data Analysis, Design Of Experiments, Detail-Oriented, Diversity & Inclusion, Drug Discovery, Ethics, Gene Therapy, Immunology, Laboratory, Lifesciences, Machine Learning (Ml), Mammalian Cell Culture, Medical Research, Molecular Biology + 11 more

Join a highly successful business and the market leader to help continue the growth of their focused and ambitious product development pipeline. Reporting to the General Manager (Singapore) you will play a crucial role in the leadership of all key in vivo projects, managing and leading highly qualified study directors. This operation is focused on the development of novel and scientifically robust approaches that provide reliable scientific evidence and data, of the highest quality, using a systems biology based approach. This helps us to understand mechanisms of disease observed in animal models and then translate these observations to human physiology - validating scientific concepts and develop new tools for future research. Using highly advanced in vivo / ex vivo systems and technology you will provide scientific expertise and guidance to the General Manager. You will bring a high level of scientific expertise and experience in developing targeted in vivo models to understand specific disease mechanisms in areas such as Lung Cancer and Chronic Obstructive Pulmonary Disease (COPD). You will be expected to interpret complex data from both in vivo and ex vivo methodology. You will have excellent written and oral communication skills and will work closely with scientific leaders, regulatory groups and senior management. You will be responsible for leading, developing and motivating a high performing BioResearch team, working directly with the Biological Systems Research group in Switzerland, responsible for the establishment and validation of novel in vivo models. Your aim is to deliver scientific data of the highest quality, leading the development of new models to enhance disease understanding. You will have direct and indirect line management responsibility in a matrix environment, leading strong multi-disciplinary and multi-cultural scientific teams, ideally with the ability to manage through influence, with excellent problem solving skills and leadership capability, whilst developing excellent relationships with stakeholders in all countries. You will have the ability to motivate others, think strategically, be an excellent communicator and possess the awareness to invest in and develop positive relationships at all levels, with a high level of comfort with senior management. Your success will be linked to your ability to develop and lead a high performing team(s) delivering science and scientific data of the highest standards, providing direction, leadership and vision. You will also be expected to gain the respect of your scientific peers and external stakeholders, such that you are recognised as a global expert within the development and use of in vivo models for Lung Cancer and COPD. This is an exciting opportunity to join a highly successful global business, within a leadership capacity, in a highly visible capacity where the long term career prospects are varied and exceptional. For further information or a discussion in complete confidence, please contact Dr Grant Coren, Location: Singapore Salary: Attractive salary and package - commensurate with experience Reference: PSL4019 Pharma-Search Ltd, Company Number:

View Vacancy MRC Postdoctoral Research Scientist LMS 2662 Open Date 11/07/2025, 10:00 Close Date 12/08/2025, 23:55 Research Institute MRC Laboratory of Medical Sciences Research Institute / Unit Information The LMS is a world-class research laboratory where scientists and clinicians collaborate to advance the understanding of biology and its application to medicine. Funded by the MRC as part of UK Research and Innovation , the LMS has a collaborative working culture and new state-of-the-art building based in the heart of West London in the Hammersmith Hospital Campus (W12). The LMS aims to deliver transdisciplinary team science, in synergistic interaction with Imperial College and the wider national research environment. Part of achieving this, is to recruit new talent and support postdoctoral scientists to become world leaders in their area of science. UK Research and Innovation is a new entity that brings together nine partners to create an independent organisation with a strong voice for research and innovation, more information can be found at Band MRC - 4 Location London £41,344 plus London allowances £5,385 per annum Additional allowances comprise a £1,000 lump sum Settlement Allowance plus a yearly Training Allowance of £850 in the first year, paid in monthly instalments. The Training Allowance increases to £1,300 in year two Contract Type Fixed Term Job Type Science Full Time / Part Time Full Time 2 years (with a possibility of extension) Job Description Overall purpose: Research Programme The Reprogramming and Chromatin group led by Prof Petra Hajkova investigates molecular processes that underlie global erasure of epigenetic information. As in vitro cellular reprogramming systems are notoriously inefficient and heterogeneous in outcome, we focus on the epigenetic reprogramming events that occur naturally in vivo during mouse development (in the mouse zygote and in the developing mouse germ cells) ( ). We have a particular interest in deciphering the mechanisms underlying the waves of global DNA demethylation (Amouroux et al, 2016, Hill et al, Nature 2018; Huang et al, Nature 2021) and the changes in chromatin structure that accompanies this process. Purpose of Post The focus of this project is to investigate molecular mechanisms underpinning zygotic and germline DNA demethylation, the mechanistic links to DNA repair and the functional relationship to the progression through the germline cycle. The ideal candidate will be expected to carry out research within the focus area of the Reprogramming and Chromatin Group; undertake project management and be involved in the supervision of PhD students in the laboratory. In addition, he/she will be expected to submit publications to refereed journals and to attract external research funding. Main duties / key responsibilities: To take initiatives in the planning of research To direct the work of small research teams To identify and develop suitable techniques, and apparatus, for the collection and analysis of data To conduct data analysis To ensure the validity and reliability of data at all times To maintain accurate and complete records of all findings To write reports for submission to research sponsors To present findings to colleagues and at conferences To submit publications to refereed journals To provide guidance to staff and students To attend relevant workshops and conferences as necessary To develop contacts and research collaborations within the College and the wider community To promote the reputation of the Group, the Department and the Institute To provide guidance to PhD Students Contribute to bids for research grants To conduct and plan own scientific work with appropriate supervision To maintain highly organised and accurate record of experimental work To actively participate in the research programme of the Group and Unit To publish in high quality journals and to present data at national and international meetings To participate in Group/Unit research meetings and internal seminars Willingness to work out of normal working hours (including weekends) if the requirements of the project demand To collaborate with other allied scientists within Institute and elsewhere in London and abroad, as appropriate To contribute to the smooth running of the Group's/Unit's laboratories and, facilities with other scientists, clinicians, technicians and students within the laboratories To assist in the supervision of undergraduate and postgraduate research students and research assistants as required To comply with the Institute safety practices and to attend courses on safety when appropriate Any other duties as may be deemed reasonable by Head of group Working relationships: The post-holder will report directly to the head of the group, Professor Petra Hajkova. Additional information: This post is an MRC Postdoctoral Scientist to support post-doctoral training and help establish successful research scientists in their chosen field. During the fellowship tenure we are committed to provide mentorship for career development and improvement of communication skills. Person Specification Education / Qualifications / Training required (will be assessed from the application): Essential: PhD degree (or equivalent experience) in a biological or related discipline Desirable: UK Home Office personal licence (PIL) for work with rodents Previous work experience required (will be assessed from the application and at the interview): Essential: Proven experience in the field of epigenetics and chromatin Experience with isolation, manipulation and culture of mouse oocytes and early mouse preimplantation embryos Extensive experience with cell lines and mouse primary cell culture techniques Experience with culture of mouse pluripotent stem cells Knowledge of relevant biochemical and molecular biology research methods and statistical procedures Good written communication skills in English Desirable: Experience with derivation of mouse embryonic stem cells Experience with NGS approaches to investigate epigenome Personal skills / Behaviours / Qualities (will be assessed at the interview): Essential: Evidence of organisational ability Good verbal communication skills in English and the ability to work effectively with researchers ranging from postgraduate students to professorial level Ability to work both independently and as part of a team IT literate and familiar with basic methods for sequence and image analysis Desirable: A highly committed individual with proactive and flexible attitude to work The ability and willingness to learn new concepts and technologies rapidly The ability to work under pressure in the competitive field Further Information Pleaseupload your CV, the names and contact details of two scientific references along with a covering letter stating why you are applying for this role (providing evidence against the requirements of the job as per the job description and person specification). Applications without a cover letter will not be considered. Please quote reference number LMS 2662. This role qualifies for endorsement by UKRI for a UK Global Talent Visa, for which the successfulapplicant is likely to be eligible to apply. Immigrationcosts for the applicant (100% visa and 100% Health Surcharge) and immediate dependents (100% visa and 50% health surcharge when applying with the main applicant) can be reclaimed from LMS after taking up the post (terms and conditions apply). Please note that applications may be reviewed by both LMS and Imperial staff The MRC is a unique working environment where scientific researchers and professional support staff can actively partake in world class innovation and collaboration opportunities and their skills and knowledge through accessing a wide catalogue of training & development, including professional registration with the Science Council. In addition, MRC (part of UKRI) provides its community of employees access to a whole host of useful benefits, including a defined benefit pension scheme and excellent holiday entitlement (30 days plus 2.5 privilege days & 8 bank holidays), family friendly policies (6 months full pay maternity & adoption leave), a range of shopping/travel discounts, access to our Employee Assistant Programme Scheme, Health and Wellbeing Support and a salary sacrifice cycle to work scheme. Please follow this link to find out more - Benefits Our success is dependent upon our ability to embrace diversity and draw on the skills, understanding and experience of all our people. We warmly invite people from diverse backgrounds and heritage, including people who identify as having a disability, to apply for a role that excites them. As "Disability Confident" employers, we guarantee to interview all applicants who have disclosed they have a disability and who meet the minimum criteria for the vacancy. . click apply for full job details

The Opportunity: The Research Services Lead is responsible for the service delivery and line management of Lab Support Associates at AMB. The role acts as the Avantor Point of Contact (POC) for all services including sample and stock management, ensuring end-to-end service linkage and provision. The primary goal is to align services and improve operational efficiency through effective communication between AZ Sci Ops, scientists, and service providers. Role Overview: The Lead will oversee activities within an in vivo facility, supporting research scientists with on-site services such as consumable and waste management, housekeeping, equipment, and enrichment activities, in collaboration with partner suppliers. The role requires understanding of compliance, ethical standards, and regulations, serving as a key liaison with regulatory bodies. Responsibilities include providing scientific and technical leadership, ensuring compliance with AAALAC protocols, animal welfare standards, and legislation. Supervisory experience in scientific support roles, particularly within in vivo settings, is essential, along with previous PIL license experience. Service Responsibilities: Experience with in vivo research; PIL license preferred Manage Avantor Lab Support teams for effective service delivery Oversee sample and stock management, supply chain activities Act as site POC for stakeholders and scientists, ensuring coordination Respond to customer requests, suggest improvements Maintain operational metrics and knowledge base Manage demand, capacity, and resource resilience Lead improvement projects using Lean methodologies Ensure services meet stakeholder and scientific expectations Managerial Responsibilities: Communicate Avantor services effectively across levels Establish escalation/support structures with Lab Operations Coordinate daily operations and performance management Maintain documentation for compliance and training Lead safety inspections and audits Support cross-site engagement and innovation sharing Prepare and analyze governance review data Report unsafe acts or conditions Manage cost-saving initiatives Role Expectations: PhD or equivalent in Biomedical Sciences, Pharmacology, or related field Knowledge of animal ethics, IACUC, AAALAC standards Line management experience In vivo facility experience and PIL license Strong service orientation, communication, and problem-solving skills Proficiency in data analysis and reporting Lean and project management skills Capabilities: Partner effectively with teams and suppliers Manage multiple stakeholders Understand internal/external team interactions and contributions Knowledge of Good Laboratory Practices and AZ compliance Leadership, change management, and quality management skills Disclaimer: These statements describe the general nature of work and are not exhaustive. Avantor is an equal opportunity employer.

The Pirbright Institute delivers world-leading research to understand, predict, detect and respond to viral disease outbreaks. We study viruses of livestock that are endemic and exotic to the UK, including zoonotic viruses, by using the most advanced tools and technologies to understand host-pathogen interactions in animals and arthropod vectors. Our major strength in understanding the immune systems of livestock provides a platform to control current diseases and respond to emerging threats. Our Institute is made up of a dynamic and vibrant community of staff covering a diverse set of chosen fields, backgrounds and experience. We all play a crucial role in furthering the Institute's aspirations, advancing the frontiers of science and knowledge through our excellent scientific research, knowledge sharing and contribution; with a real focus in improving the world in which we live. Our outlook is always balanced by our strong sense of purpose, values and behaviours and an unwavering commitment to a 'one Institute' approach. Organisation position and purpose The Pirbright Institute is seeking a highly motivated Postdoctoral Scientist to join Professor Simon Graham's research group as part of an international team tackling Nipah virus, a high-priority zoonotic pathogen. This role is funded through the UKRI-Southeast Asia Collaboration on Infectious Diseases and offers an exciting opportunity to contribute to the development of next-generation vaccines and therapeutics. About the project: Titled "DNA-launched Nipah virus vaccines and therapeutics," this project aims to leverage our innovative DNA-delivery platform to create effective, affordable, and scalable interventions against Nipah virus. Our cutting-edge polymer/peptide nano-formulation technology enables efficient DNA vector delivery, presenting a promising and deployable vaccination and treatment strategy. The project is a collaboration between The Pirbright Institute, the University of Nottingham (UK), and the University of Malaya (Malaysia) and aims to generate the crucial preclinical efficacy data needed for further clinical translation. Professor Simon Graham will serve as the UK Project Lead and direct line manager for the postholder. This is a fantastic opportunity for a postdoctoral scientist passionate about virology, immunology, and translational research to make a tangible impact in global infectious disease control. Main duties and responsibilities: Preclinical Evaluation of DNA-Vectored Therapeutics & Vaccines Conduct pharmacokinetic studies on DNA-vectored therapeutic monoclonal antibodies and assess the immunogenicity of DNA-vectored vaccines in mice and pigs. Produce and purify key research materials, including recombinant Nipah virus glycoproteins, monoclonal antibodies, and pseudo viruses. Coordinate animal studies in collaboration with project partners and contract research organizations, ensuring adherence to study protocols. Analyse antibody responses using pseudovirus neutralization assays and ELISA techniques. Assess T cell responses through IFN-γ ELISpot assays and flow cytometric analysis. Contribute to the development and optimization of novel techniques and methodologies for vaccine response analysis. Collaborative Research & Project Contributions Support the isolation of novel therapeutic monoclonal antibodies from human Nipah virus survivors by providing purified recombinant glycoproteins. Present research updates at monthly consortium meetings and collaborate effectively with international research partners. Disseminate findings by preparing high-quality, peer-reviewed manuscripts and delivering presentations at scientific conferences. Maintain comprehensive health, safety, and biosecurity documentation to ensure a safe research environment. Assist in lab management tasks, including ordering supplies, maintaining equipment, and overseeing sample inventories. Due to the nature of the work we do, all successful applicants will be required to go through a comprehensive screening process including reference and qualification checks, financial and security clearances. Essential/Desirable requirements A PhD or equivalent in a relevant branch of biosciences An excellent record of research productivity, relative to experience Experience of recombinant protein and/or monoclonal antibody expression and purification Experience in immunology including analysis of antibody responses e.g. ELISAs and virus neutralisation assays and T cell responses e.g., flow cytometry Evidence of excellent oral and written communication skills Experience of vaccine/therapeutic antibody R&D Experience of working with large animals Experience of working with viruses Experience of working in international research consortia What we offer Generous Group Personal Pension Scheme and life cover (subject to age and earnings) 25 days annual leave per annum, pro rata, plus 10.5 public and privilege days Buy and sell annual leave Option to carry over up to two weeks annual leave Pirbright gym with subsidised membership Pirbright social club Pirbright Lifestyle Hub (employee discount site) Cycle to work Subsidised employee restaurant Childcare allowance Free onsite parking Electric car charging facilities Due to the high volume of applications we receive, if you have not heard from us within one month from closing date of the vacancy, then please contact us on for an update.

Cancer Research UK Manchester Institute - Postdoctoral Scientist (Leukaemia Biology) Job Title: Postdoctoral Scientist (Leukaemia Biology) Category: Other Closing Date: 31/03/2025 About the role: A postdoctoral scientist position is available in the laboratory of Prof Tim Somervaille to study/investigate the therapeutic targeting of transcription factor:co-activator recruitment in myeloid blood cancers. Background: Over the last decade, the Leukaemia Biology Laboratory at the Cancer Research UK Manchester Institute has delivered a successful programme of bench-to-bedside translational research in myeloid blood cancer, with significant impacts in other haematological cancers such as myeloma and lymphoma. Our focus has been on understanding the basic biology of transcription factors, their co-activators and co-repressors. With this knowledge, we have then collaborated with colleagues in medicinal chemistry and in the pharmaceutical industry to drug these targets and bring them through a succession of clinical trials with patient benefit being the longer-term goal. Some key examples of this include our work on LSD1 and more recently our work with a bromodomain inhibitor of the histone acetyltransferases EP300/CBP. Building on these and other recent successes, we now seek to appoint a postdoctoral researcher who will continue and expand our work in the area of translational myeloid leukaemia epigenetics, therapeutics and gene regulation. The programme of work will be focused on understanding how critical transcription factors involved in acute myeloid leukaemia recruit essential co-activators and/or co-repressors to chromatin and whether these recruitment domains can be targeted for therapeutic benefit, as has been the case, for example, with menin inhibition in AML. About you: You should have a PhD in a biomedical discipline. A background in leukaemia research and/or chromatin & epigenetics is desirable but not essential. You should have a strong track record of past accomplishments, with wet lab experimental skills and excellent writing skills. Significant experience in ChIP sequencing and/or mass spectrometry would be advantageous together with good experience in analysis of the arising datasets, although this post will be supported by colleagues within our core bioinformatics facility. Experience with in vivo work would also be a benefit. Starting salary in the range: £37,000 - £44,852 (dependent upon qualifications and experience) Job Ref: MI/25/11 Duration: 3 years fixed term (in the first instance) extended up to a total of 7 years, subject to successful reviews Why choose Cancer Research UK Manchester Institute? The Cancer Research UK Manchester Institute (), an Institute of The University of Manchester (), is a world-leading centre for excellence in cancer research. The Institute is core funded by Cancer Research UK (), the largest independent cancer research organisation in the world. In Spring 2023, the Institute moved into the new Paterson Building, a £150 million purpose-built biomedical research centre directly attached to The Christie NHS Foundation Trust (), in South Manchester. We are partnered with The Christie NHS Foundation Trust, one of the largest cancer treatment centres in Europe. These factors combine to provide an exceptional environment in which to pursue basic, translational and clinical research programmes. How to apply? To apply for this position please visit our website: For any informal enquiries about this post, please contact Tim Somervaille: