Postdoctoral Research Scientist in Metagenomics Job Title Postdoctoral Research Scientist in Metagenomics Post Number Closing Date 8 Jul 2025 Grade SC6 Starting Salary Salary: £36,720-£42,000 Funding End Date 16 Jul 2026 Hours per week 37 Project Title Microbial drivers of atmospheric methane emission Expected/Ideal Start Date 01 Aug 2025 Months Duration 9 Interview Date 14 Jul 2025 Job Description Main Purpose of the Job Applications are invited for a Research Scientist to join the Laboratory of Dr Hildebrand at the Quadram Institute Bioscience (QIB), Norwich, UK. This post is part of a NERC project revealing the role of ammonia oxidising archaea in methane oxidation in the environment. The postholder will work with sequencing data derived from cultivated and natural soil microbiomes, to understand the role of prokaryotes (Archaea and Bacteria) in mitigating greenhouse gas emissions. Specifically, pipelines for SIP-enriched metagenomic sequencing and functional-targeted amplicon sequencing data will be developed (based on existing work in the group) and applied to interpret experiments conducted in the laboratory of collaborators. The project holder will use metagenomics (similar to doi:10.1038/s-6, 10 15314, 10.1186/s5-1) to profile both taxonomic and functional compositions of for SIP-enriched metagenomic sequencing and functional-targeted amplicon sequencing and metatranscriptomics data. The bioinformatic tools will be developed to analyse and correct these data types, the statistical workflows established to interpret and understand how ammonia oxidising microorganisms respond to methane in soil. Long-term, this work will contribute to reducing the impact of climate changes by manipulating existing microbial communities, and understanding how healthy soil microbiomes are established and maintained. Key Relationships The post holder will work closely with other group members, the line manager Dr Falk Hildebrand and collaborators Profs Laura Lehtovirta-Morley and Fred Warren. The applicant is expected to help in the supervision of junior group members and to represent the group at trainings. The applicant will have direct access to established PacBio/ONT, Hi-C and single cell sequencing facilities, as well as one of UK's largest HPC cluster at the NRP. Main Activities & Responsibilities Percentage Process and analyse soil metagenomes/metatranscriptomes 30 Use machine learning/statistics to characterize & predict community states 25 Develop new bioinformatic tools to process specialized metagenomic sequence data 25 Support group with tasks such as outreach, student supervision, writing grants 15 As agreed with the line manager, any other duties commensurate with the nature of the post, for example, contributing to the work of Institute committees 5 Person Profile Education & Qualifications Requirement Importance PhD in Bioinformatics, Soil science, Ecology or Microbiology, or equivalent experience Essential Specialist Knowledge & Skills Requirement Importance Programming skills (e.g. C++, Perl, python or R) Essential Understanding of microbiomes, preferably environmental and soil microbiomes Essential Ability to troubleshoot and solve problems Essential Initiative and a desire to learn, to innovate, and to move out of their comfort zone Essential Ability to work independently on research projects Desirable Requirement Importance Familiarity with sequencing related, metagenomics, or metatranscriptomics, or soil microbial bioinformatics Essential Bioinformatics experience Essential Proven track-record of research output at the appropriate level Essential Experience grant writing or supervising lab members Desirable Interpersonal & Communication Skills Requirement Importance Excellent communication skills, both written and oral Essential Promotes and strives for continuous improvement Essential Excellent interpersonal skills, with the ability to work alone and as part of a team Essential Reliable and conscientious Essential Additional Requirements Requirement Importance Attention to detail Essential Promotes equality and values diversity Essential Willingness to embrace the expected values and behaviours of all staff at the Institute, ensuring it is a great place to work Essential Able to present a positive image of self and the Institute, promoting both the international reputation and public engagement aims of the Institute Essential Willingness to work outside standard working hours when required Essential Willingness to undertake any necessary training for the role Essential Who We Are Quadram Institute Bioscience The Quadram Institute is at the forefront of a new interface between food science, gut biology and health, developing solutions to worldwide challenges in food-related disease and human health. We are engaged in fundamental and translational food and health research, alongside clinical studies, endoscopy and industry, working together to become a leading international hub for food and health research, combining scientific excellence and clinical expertise, delivering impacts on patient care and accelerating innovation. The Quadram Institute is a diverse and multicultural scientific community. We thrive on our international and European links, appointing staff from across the world. Any candidate who would like further information on current or anticipated immigration requirements can contact the HR Team on (0) or . The Hildebrand group uses meta omics to research the diversity, community interactions, and evolution of microbes in communities. Currently the group has projects in both human associated and environmental (soil, lakes) microbiomes, for which custom bioinformatic solutions are developed in-house to enable a wholistic microbiome exploration. We advocate strain-resolved metagenomics and develop the numerical solutions to work with MAGs intra-specific phylogenies. For representative publications relevant to the post please see (doi: 10.1016/j.chom.2023.05.024 , 10.1101/2024.09.09. , 10.1016/j.chom.2021.05.008) and for group information. The Quadram Institute is based on the Norwich Research Park, which is one of the largest single-site concentrations of research in food, genomics, and health in Europe. The Park hosts 4 BBSRC Institutes (including Earlham), 17,000 students, 3,000 full-time researchers and clinicians, and over 115 companies. The outstanding reputation of our researchers is internationally recognised, with 10 of the Park's scientists in the top 1% of the "most highly cited" in the world, including Dr Falk Hildebrand. Research Scientist (Soil metagenomics) Applications are invited for a Research Scientist to join the Laboratory of Dr Hildebrand at Quadram Institute, Norwich, UK. Background: This post is part of the NERC project "Identifying novel microbial drivers to mitigate atmospheric methane emission". Methane is a powerful greenhouse gas, and we aim to reveal the role of ammonia oxidizing Archaea in methane oxidation in the environment. The project will determine how methane affects soil microbial communities, and how specific soil microorganisms respond to methane and metabolise it. The postholder will work with sequencing data derived from cultivated and natural soil microbiomes, to understand the roleof prokaryotes (Archaea and Bacteria) in mitigating greenhouse gas emissions. The role: The project holder will use metagenomics (similar to doi:10.1038/s-6, 10 15314, 10.1186/s5-1) to profile both taxonomic and functional compositions of for SIP-enriched metagenomic and metatranscriptomic sequencing and functional-targeted amplicon sequencing data, interpreting experiments conducted in the laboratory of Prof Laura Lehtovirta-Morley. The bioinformatic tools will be developed to analyse and correct these data types, the statistical workflows established to interpret and understand how microorganisms respond to methane in both pristine and laboratory-based soil communities, building on tools available in the Hildebrand group . Long-term, this work will advance our understanding of biogeochemical cycling, contribute to reducing the impact of climate change by manipulating existing microbial communities, and understanding how healthy soil microbiomes are established, and maintained. The environment: The Hildebrand group uses metagenomics to research the diversity, community interactions, and evolution of microbes in communities using custom software solutions. The Lehtovirta-Morley group explores environmental microbiomes and biogeochemical cycling using both cultivation-independent and cultivation-dependent experiments. Both groups collaborate closely on microbial archaeal research in soils. The research is situated at the Norwich Research Park (NRP) UK, that encompasses the University of East Anglia, 4 BBSRC Institute, > 15 companies, 3,000 researchers and clinicians, 17,000 students. Norwich ranked in the top 10 for UK cities with a beautiful, historical town centre and an active gastropub & coffee aficionado scene. The applicant is expected to help in the supervision of junior group members and to represent the group at trainings. The applicant will have direct access to established PacBio/ONT, Hi-C and single cell sequencing facilities, as well as one of UK's largest HPC cluster at the NRP. The ideal candidate: The applicant needs to hold a PhD (or equivalent) in biology, bioinformatics . click apply for full job details
Jun 18, 2025
Full time
Postdoctoral Research Scientist in Metagenomics Job Title Postdoctoral Research Scientist in Metagenomics Post Number Closing Date 8 Jul 2025 Grade SC6 Starting Salary Salary: £36,720-£42,000 Funding End Date 16 Jul 2026 Hours per week 37 Project Title Microbial drivers of atmospheric methane emission Expected/Ideal Start Date 01 Aug 2025 Months Duration 9 Interview Date 14 Jul 2025 Job Description Main Purpose of the Job Applications are invited for a Research Scientist to join the Laboratory of Dr Hildebrand at the Quadram Institute Bioscience (QIB), Norwich, UK. This post is part of a NERC project revealing the role of ammonia oxidising archaea in methane oxidation in the environment. The postholder will work with sequencing data derived from cultivated and natural soil microbiomes, to understand the role of prokaryotes (Archaea and Bacteria) in mitigating greenhouse gas emissions. Specifically, pipelines for SIP-enriched metagenomic sequencing and functional-targeted amplicon sequencing data will be developed (based on existing work in the group) and applied to interpret experiments conducted in the laboratory of collaborators. The project holder will use metagenomics (similar to doi:10.1038/s-6, 10 15314, 10.1186/s5-1) to profile both taxonomic and functional compositions of for SIP-enriched metagenomic sequencing and functional-targeted amplicon sequencing and metatranscriptomics data. The bioinformatic tools will be developed to analyse and correct these data types, the statistical workflows established to interpret and understand how ammonia oxidising microorganisms respond to methane in soil. Long-term, this work will contribute to reducing the impact of climate changes by manipulating existing microbial communities, and understanding how healthy soil microbiomes are established and maintained. Key Relationships The post holder will work closely with other group members, the line manager Dr Falk Hildebrand and collaborators Profs Laura Lehtovirta-Morley and Fred Warren. The applicant is expected to help in the supervision of junior group members and to represent the group at trainings. The applicant will have direct access to established PacBio/ONT, Hi-C and single cell sequencing facilities, as well as one of UK's largest HPC cluster at the NRP. Main Activities & Responsibilities Percentage Process and analyse soil metagenomes/metatranscriptomes 30 Use machine learning/statistics to characterize & predict community states 25 Develop new bioinformatic tools to process specialized metagenomic sequence data 25 Support group with tasks such as outreach, student supervision, writing grants 15 As agreed with the line manager, any other duties commensurate with the nature of the post, for example, contributing to the work of Institute committees 5 Person Profile Education & Qualifications Requirement Importance PhD in Bioinformatics, Soil science, Ecology or Microbiology, or equivalent experience Essential Specialist Knowledge & Skills Requirement Importance Programming skills (e.g. C++, Perl, python or R) Essential Understanding of microbiomes, preferably environmental and soil microbiomes Essential Ability to troubleshoot and solve problems Essential Initiative and a desire to learn, to innovate, and to move out of their comfort zone Essential Ability to work independently on research projects Desirable Requirement Importance Familiarity with sequencing related, metagenomics, or metatranscriptomics, or soil microbial bioinformatics Essential Bioinformatics experience Essential Proven track-record of research output at the appropriate level Essential Experience grant writing or supervising lab members Desirable Interpersonal & Communication Skills Requirement Importance Excellent communication skills, both written and oral Essential Promotes and strives for continuous improvement Essential Excellent interpersonal skills, with the ability to work alone and as part of a team Essential Reliable and conscientious Essential Additional Requirements Requirement Importance Attention to detail Essential Promotes equality and values diversity Essential Willingness to embrace the expected values and behaviours of all staff at the Institute, ensuring it is a great place to work Essential Able to present a positive image of self and the Institute, promoting both the international reputation and public engagement aims of the Institute Essential Willingness to work outside standard working hours when required Essential Willingness to undertake any necessary training for the role Essential Who We Are Quadram Institute Bioscience The Quadram Institute is at the forefront of a new interface between food science, gut biology and health, developing solutions to worldwide challenges in food-related disease and human health. We are engaged in fundamental and translational food and health research, alongside clinical studies, endoscopy and industry, working together to become a leading international hub for food and health research, combining scientific excellence and clinical expertise, delivering impacts on patient care and accelerating innovation. The Quadram Institute is a diverse and multicultural scientific community. We thrive on our international and European links, appointing staff from across the world. Any candidate who would like further information on current or anticipated immigration requirements can contact the HR Team on (0) or . The Hildebrand group uses meta omics to research the diversity, community interactions, and evolution of microbes in communities. Currently the group has projects in both human associated and environmental (soil, lakes) microbiomes, for which custom bioinformatic solutions are developed in-house to enable a wholistic microbiome exploration. We advocate strain-resolved metagenomics and develop the numerical solutions to work with MAGs intra-specific phylogenies. For representative publications relevant to the post please see (doi: 10.1016/j.chom.2023.05.024 , 10.1101/2024.09.09. , 10.1016/j.chom.2021.05.008) and for group information. The Quadram Institute is based on the Norwich Research Park, which is one of the largest single-site concentrations of research in food, genomics, and health in Europe. The Park hosts 4 BBSRC Institutes (including Earlham), 17,000 students, 3,000 full-time researchers and clinicians, and over 115 companies. The outstanding reputation of our researchers is internationally recognised, with 10 of the Park's scientists in the top 1% of the "most highly cited" in the world, including Dr Falk Hildebrand. Research Scientist (Soil metagenomics) Applications are invited for a Research Scientist to join the Laboratory of Dr Hildebrand at Quadram Institute, Norwich, UK. Background: This post is part of the NERC project "Identifying novel microbial drivers to mitigate atmospheric methane emission". Methane is a powerful greenhouse gas, and we aim to reveal the role of ammonia oxidizing Archaea in methane oxidation in the environment. The project will determine how methane affects soil microbial communities, and how specific soil microorganisms respond to methane and metabolise it. The postholder will work with sequencing data derived from cultivated and natural soil microbiomes, to understand the roleof prokaryotes (Archaea and Bacteria) in mitigating greenhouse gas emissions. The role: The project holder will use metagenomics (similar to doi:10.1038/s-6, 10 15314, 10.1186/s5-1) to profile both taxonomic and functional compositions of for SIP-enriched metagenomic and metatranscriptomic sequencing and functional-targeted amplicon sequencing data, interpreting experiments conducted in the laboratory of Prof Laura Lehtovirta-Morley. The bioinformatic tools will be developed to analyse and correct these data types, the statistical workflows established to interpret and understand how microorganisms respond to methane in both pristine and laboratory-based soil communities, building on tools available in the Hildebrand group . Long-term, this work will advance our understanding of biogeochemical cycling, contribute to reducing the impact of climate change by manipulating existing microbial communities, and understanding how healthy soil microbiomes are established, and maintained. The environment: The Hildebrand group uses metagenomics to research the diversity, community interactions, and evolution of microbes in communities using custom software solutions. The Lehtovirta-Morley group explores environmental microbiomes and biogeochemical cycling using both cultivation-independent and cultivation-dependent experiments. Both groups collaborate closely on microbial archaeal research in soils. The research is situated at the Norwich Research Park (NRP) UK, that encompasses the University of East Anglia, 4 BBSRC Institute, > 15 companies, 3,000 researchers and clinicians, 17,000 students. Norwich ranked in the top 10 for UK cities with a beautiful, historical town centre and an active gastropub & coffee aficionado scene. The applicant is expected to help in the supervision of junior group members and to represent the group at trainings. The applicant will have direct access to established PacBio/ONT, Hi-C and single cell sequencing facilities, as well as one of UK's largest HPC cluster at the NRP. The ideal candidate: The applicant needs to hold a PhD (or equivalent) in biology, bioinformatics . click apply for full job details
Our client is a leading provider of Next Generation Sequencing (NGS) solutions to support the ongoing development of genetic-based medicine. An opportunity has now become available for an experienced NGS scientist to join the company and support with the product development projects within their NGS platforms. The role: The successful applicant will be responsible for: Acting as technical lead on R&D projects for the improvement and development of NGS assays Oversee project delivery, outlining practical resources, delivery criteria and milestones Deliver project results and present data through internal and external meetings Suitable applicants: Research and/or Postdoctoral experience focussed on NGS development, including troubleshooting and validation, for commercial applications. Proven experience performing R&D projects, with clear evidence of managing timelines and deliverables Educated to PhD in Genomics/Molecular Biology (or equivalent experience) Deep knowledge of Next Generation Sequencing Good commercial acumen with understanding of product pipelines Suitable candidates can expect a permanent position with a competitive salary commensurate to experience (plus benefits) I'm interested in this job Please use the form provided to get in touch with us and we will respond as soon as possible. Compulsory fields are in bold . I'm interested in this job Please use the form provided to get in touch with us and we will respond as soon as possible. Compulsory fields are in bold . Name Email address Telephone Message Upload C.V. Your file must be in one of the following formats: pdf , doc , docx , rtf , txt and no larger than 2MB . Recaptcha requires verification. I'm not a robot reCAPTCHA Privacy - Terms
Jun 17, 2025
Full time
Our client is a leading provider of Next Generation Sequencing (NGS) solutions to support the ongoing development of genetic-based medicine. An opportunity has now become available for an experienced NGS scientist to join the company and support with the product development projects within their NGS platforms. The role: The successful applicant will be responsible for: Acting as technical lead on R&D projects for the improvement and development of NGS assays Oversee project delivery, outlining practical resources, delivery criteria and milestones Deliver project results and present data through internal and external meetings Suitable applicants: Research and/or Postdoctoral experience focussed on NGS development, including troubleshooting and validation, for commercial applications. Proven experience performing R&D projects, with clear evidence of managing timelines and deliverables Educated to PhD in Genomics/Molecular Biology (or equivalent experience) Deep knowledge of Next Generation Sequencing Good commercial acumen with understanding of product pipelines Suitable candidates can expect a permanent position with a competitive salary commensurate to experience (plus benefits) I'm interested in this job Please use the form provided to get in touch with us and we will respond as soon as possible. Compulsory fields are in bold . I'm interested in this job Please use the form provided to get in touch with us and we will respond as soon as possible. Compulsory fields are in bold . Name Email address Telephone Message Upload C.V. Your file must be in one of the following formats: pdf , doc , docx , rtf , txt and no larger than 2MB . Recaptcha requires verification. I'm not a robot reCAPTCHA Privacy - Terms
Contract - Initially a 2 year fixed term contract - onsite. Salary - £40,000 - £45,000 depending on experience. Our client are a scientifically passionate company who lead extensive collaborations and offer services to the Drug Discovery and Disease Research sectors. They collaborate with lead researchers and organisations to enhance the understanding of immunological, oncological, neurological and other disease areas. Based in Alderley Park, they are offering an exciting opportunity for an enthusiastic and hard-working individual to join their in vivo imaging team as a Senior Scientist. If you are looking to work on exciting translational in vivo imaging projects and want to further your career, then this could be the opportunity you have been waiting for. The Role This is a role for experienced Imaging Scientists who hold a PhD (or Master's) in a biologically focused discipline, with additional postdoctoral or industry experience. As a Senior Imaging Scientist, you will be responsible for: Designing and running mouse + rodent PET / in vivo imaging studies for a range of purposes including biodistribution, pharmacokinetics (PK) and cellular responses. Leading exciting projects relating to lipid nanoparticle based therapeutics. Delivery of high quality experimental data and presenting this to external partners. Oversee and manage projects spanning multiple organisations, from conception to completion. Innovating in the in vivo imaging space to bring new technologies or ways of applying the technology to projects. Adhering to regulations and guidelines for in vivo work, including Home-Office project licence. Labelling / radiolabelling of LNPs (optional) Skills and Experience Needed: Suitable applicants must have: A PhD or Master's - focused around biological imaging (essential) Significant experience of developing pre-clinical in vivo mouse and rodent models (essential) Hold a personal Home Office PIL ABC licence (essential) Must have significant experience in positron emission tomography (PET) imaging and data analysis + image reconstruction tools (essential) Proven experience of routine in vivo techniques such as tissue collection, blood sampling, dosing via common routes etc (essential) Experience in leading, or influencing complex scientific projects (essential) Strong experience in ex vivo techniques like immunohistochemistry (IHC), immunofluorescence staining, microscopy etc (essential) Good communication and problem-solving skills (essential) Suitable applicants could have: Experience working on complex projects spanning across multiple organisation types (CRO, biotech, medical research charity, academia, etc) (desired) Experience in other in vivo imaging techniques including SPECT, IVIS, MRI etc (nice to have) PMOD image analysis software experience (desired) Radioligand labelling experience (nice to have) Working on lipid nanoparticle (LNP) within formulation, dosing or translational studies (nice to have) Prior industry experience in an SME or pharmaceutical company (desired) The Package Being a leading collaborative drug discovery company, our client is offering the chance to be part of a growing organisation on a temporary basis, with a competitive salary and benefits package. To Apply If you would like to submit an application for this position, please contact Charlie Cox on , or send an email to I'm interested in this job Please use the form provided to get in touch with us and we will respond as soon as possible. Compulsory fields are in bold . I'm interested in this job Please use the form provided to get in touch with us and we will respond as soon as possible. Compulsory fields are in bold . Name Email address Telephone Message Upload C.V. Your file must be in one of the following formats: pdf , doc , docx , rtf , txt and no larger than 2MB . Recaptcha requires verification. I'm not a robot reCAPTCHA Privacy - Terms
Jun 17, 2025
Full time
Contract - Initially a 2 year fixed term contract - onsite. Salary - £40,000 - £45,000 depending on experience. Our client are a scientifically passionate company who lead extensive collaborations and offer services to the Drug Discovery and Disease Research sectors. They collaborate with lead researchers and organisations to enhance the understanding of immunological, oncological, neurological and other disease areas. Based in Alderley Park, they are offering an exciting opportunity for an enthusiastic and hard-working individual to join their in vivo imaging team as a Senior Scientist. If you are looking to work on exciting translational in vivo imaging projects and want to further your career, then this could be the opportunity you have been waiting for. The Role This is a role for experienced Imaging Scientists who hold a PhD (or Master's) in a biologically focused discipline, with additional postdoctoral or industry experience. As a Senior Imaging Scientist, you will be responsible for: Designing and running mouse + rodent PET / in vivo imaging studies for a range of purposes including biodistribution, pharmacokinetics (PK) and cellular responses. Leading exciting projects relating to lipid nanoparticle based therapeutics. Delivery of high quality experimental data and presenting this to external partners. Oversee and manage projects spanning multiple organisations, from conception to completion. Innovating in the in vivo imaging space to bring new technologies or ways of applying the technology to projects. Adhering to regulations and guidelines for in vivo work, including Home-Office project licence. Labelling / radiolabelling of LNPs (optional) Skills and Experience Needed: Suitable applicants must have: A PhD or Master's - focused around biological imaging (essential) Significant experience of developing pre-clinical in vivo mouse and rodent models (essential) Hold a personal Home Office PIL ABC licence (essential) Must have significant experience in positron emission tomography (PET) imaging and data analysis + image reconstruction tools (essential) Proven experience of routine in vivo techniques such as tissue collection, blood sampling, dosing via common routes etc (essential) Experience in leading, or influencing complex scientific projects (essential) Strong experience in ex vivo techniques like immunohistochemistry (IHC), immunofluorescence staining, microscopy etc (essential) Good communication and problem-solving skills (essential) Suitable applicants could have: Experience working on complex projects spanning across multiple organisation types (CRO, biotech, medical research charity, academia, etc) (desired) Experience in other in vivo imaging techniques including SPECT, IVIS, MRI etc (nice to have) PMOD image analysis software experience (desired) Radioligand labelling experience (nice to have) Working on lipid nanoparticle (LNP) within formulation, dosing or translational studies (nice to have) Prior industry experience in an SME or pharmaceutical company (desired) The Package Being a leading collaborative drug discovery company, our client is offering the chance to be part of a growing organisation on a temporary basis, with a competitive salary and benefits package. To Apply If you would like to submit an application for this position, please contact Charlie Cox on , or send an email to I'm interested in this job Please use the form provided to get in touch with us and we will respond as soon as possible. Compulsory fields are in bold . I'm interested in this job Please use the form provided to get in touch with us and we will respond as soon as possible. Compulsory fields are in bold . Name Email address Telephone Message Upload C.V. Your file must be in one of the following formats: pdf , doc , docx , rtf , txt and no larger than 2MB . Recaptcha requires verification. I'm not a robot reCAPTCHA Privacy - Terms
Hours per week 37 Project Title Mechanism of multiple drug resistance and genetic evolution of prevalent Salmonella serotypes derived from animals Expected/Ideal Start Date 01 Oct 2025 Months Duration 18 Flexible Options Although full-time hours are available, applications from those interested in working part-time hours are also welcomed. Job Description Main Purpose of the Job The post holder will work in a Research Scientist role on a project funded by the MRC's UK-China One Health Research for Epidemic Preparedness and AMR call. This project is a collaboration between the University of Lincoln, the Quadram Institute Bioscience and Chinese partners investigating the mechanisms of multiple drug resistance and genetic evolution of Salmonella serotypes in pig and poultry farming. The post holder will contribute to the QIB work packages involving the co-evolution of Salmonella and bacteriophages (both virulent and temperate) and mechanisms of phage resistance development. The post holder is expected to attend national project meetings and coordinate the dissemination of results, including the publication of high-quality research papers and presenting findings at scientific conferences.The post holder will be embedded in the Bacteriophages & Viromics research group led by Dr Evelien Adriaenssens, which is a vibrant research group consisting of postdocs and PhD candidates. In the group, the post holder will be given the opportunity to supervise and mentor more junior scientists and visiting researchers. Furthermore, the post holder will have access to the Norwich Bioscience Institutes' extensive training programme and given the opportunity to enrol in training courses related to bioinformatics and career development. Continuous learning and improvement are expected. Key Relationships Evelien Adriaenssens (line manager) The post holder will work with other group members at the Adriaenssens group as well as other members of the Quadram Institute Bioscience. The post holder is expected to develop and maintain strong working relationships with the partners in the grant, in particular at the University of Lincoln, and with the Chinese partners working in parallel. Further key relationships are with members of the Quadram Science Voice, and members of the other research institutes of the Norwich Bioscience Institutes and the University of East Anglia. Main Activities & Responsibilities Percentage Establishment, maintenance and characterisation of bacteriophage collection for Salmonella 25 Development of resistant mutants of Salmonella and phenotypic characterisation 25 Bioinformatic analysis of Salmonella genomes in relation to AMR determinants, phage resistance and mobilisation 25 Dissemination of results through publication of scientific papers, media posts, and attending scientific conferences 15 Assist with supervising students and visiting workers in the group 5 As agreed with the line manager, any other duties commensurate with the nature of the post, for example, contributing to the work of Institute committees. 5 Person Profile Education & Qualifications Requirement Importance PhD in Microbiology, Biotechnology, Bioscience Engineering or a related Life Science subject (or equivalent experience) Essential Specialist Knowledge & Skills Requirement Importance Excellent microbiology laboratory skills Essential Microbiology techniques related to phage and/or bacteria culturing Essential Bioinformatics skills related to bacterial genomics Essential Proven record of publications appropriate with experience Essential Requirement Importance Laboratory experience in bacterial pathogen handling Essential Experience in molecular biology Essential Experience in working collaboratively Essential Experience in working with bacteriophages Desirable Interpersonal & Communication Skills Requirement Importance Good communication skills, both written and verbal Essential Good interpersonal skills, with the ability to work well as part of a team Essential Ability to work to deadlines Essential Ability to work and manage projects independently Essential Additional Requirements Requirement Importance Attention to detail Essential Embraces and promotes equity, diversity and inclusion in the workplace Essential Willingness to travel for project meetings Essential Willingness to embrace the expected values and behaviours of all staff at the Institute, ensuring it is a great place to work Essential Able to present a positive image of self and the Institute, promoting both the international reputation and public engagement aims of the Institute Essential Willingness to work outside standard working hours when required Essential Promotes equality and values diversity Essential Who We Are Quadram Institute Bioscience The Quadram Institute is at the forefront of a new interface between food science, gut biology and health, developing solutions to worldwide challenges in food-related disease and human health. We are engaged in fundamental and translational food and health research, alongside clinical studies, endoscopy and industry, working together to become a leading international hub for food and health research, combining scientific excellence and clinical expertise, delivering impacts on patient care and accelerating innovation. The Quadram Institute is a diverse and multicultural scientific community. We thrive on our international and European links, appointing staff from across the world. Any candidate who would like further information on current or anticipated immigration requirements can contact the HR Team on (0) or . The Adriaenssens group is a vibrant and collaborative research group looking into all things phage, consisting of three postdoctoral scientists and three PhD students. We use culture-dependent and independent approaches to understand the role of bacteriophages as part of a range of microbiomes, working both with single phage-host pairs and complex microbial communities. We have a strong interest in the use of bacteriophages as biocontrol agents for pathogenic bacteria. Research Scientist Applications are invited for a Research Scientist to join the Laboratory of Dr Evelien Adriaenssens in the Microbes and Food Safety programme at Quadram Institute Bioscience (QIB), based in Norwich, UK. Background: The Adriaenssens group is a vibrant and collaborative research group looking into all things phage. We use culture-dependent and independent approaches to understand the role of bacteriophages as part of a range of microbiomes, working both with single phage-host pairs and complex microbial communities. We have a strong interest in the use of bacteriophages as biocontrol agents for pathogenic bacteria. The role: As a Research Scientist on the MRC-funded project "Mechanism of multiple drug resistance and genetic evolution of prevalent Salmonella serotypes derived from animals", the post holder will contribute to the delivery of the objectives of the grant. Specifically, the post holder will investigate diverse Salmonella serovars across the food chain and the mechanisms of resistance development to bacteriophages and antibiotics. Key relationships will be developed with the Onarinde team at the University of Lincoln. The Research Scientist will help organise and attend project meetings and contribute to communication and dissemination of results, including presentation of findings at scientific conferences and the publication of papers. The post holder will be given the opportunity to enrol in training courses related to career development or technical skills, and will assist in the daily supervision of undergraduate and/or postgraduate students at QIB. The ideal candidate: The ideal candidate will hold a PhD in Microbiology, Biotechnology, Bioscience Engineering or a related Life Science subject (or expected to finish by post start) and is passionate about bacteriophages and food safety. The responsibilities will be split between laboratory work in phage and bacteria culturing, development of resistant mutants and genomics. The ideal candidate is therefore flexible and able to handle lab work and sequencing data in parallel. Good communications skills and the ability to coordinate with team members to deliver objectives are essential. Additional information: Salary on appointment will be within the range £36,720 to £39,750 per annum depending on qualifications and experience. This is a full-time post for a contract of 18 months. For further information and details of how to apply, please visit our website or contact the Human Resources team on or quoting reference . This role meets the criteria for a visa application, and we encourage all qualified candidates to apply. Please contact the Human Resources Team if you have any questions regarding your application or visa options. We are committed to equity, diversity and inclusion, and welcome applications from all sectors of society. The Institute values of Respect, Innovation, Collaboration and Excellence are at the heart of all we do, and we expect all employees to share and display these values. To support our commitment, we have a range of family, faith and diversity friendly working arrangements to help all staff achieve excellence in their area of work. As a Disability Confident employer, we guarantee to offer an interview to all disabled applicants who meet the essential criteria for this vacancy. About the Quadram Institute: . click apply for full job details
Jun 14, 2025
Full time
Hours per week 37 Project Title Mechanism of multiple drug resistance and genetic evolution of prevalent Salmonella serotypes derived from animals Expected/Ideal Start Date 01 Oct 2025 Months Duration 18 Flexible Options Although full-time hours are available, applications from those interested in working part-time hours are also welcomed. Job Description Main Purpose of the Job The post holder will work in a Research Scientist role on a project funded by the MRC's UK-China One Health Research for Epidemic Preparedness and AMR call. This project is a collaboration between the University of Lincoln, the Quadram Institute Bioscience and Chinese partners investigating the mechanisms of multiple drug resistance and genetic evolution of Salmonella serotypes in pig and poultry farming. The post holder will contribute to the QIB work packages involving the co-evolution of Salmonella and bacteriophages (both virulent and temperate) and mechanisms of phage resistance development. The post holder is expected to attend national project meetings and coordinate the dissemination of results, including the publication of high-quality research papers and presenting findings at scientific conferences.The post holder will be embedded in the Bacteriophages & Viromics research group led by Dr Evelien Adriaenssens, which is a vibrant research group consisting of postdocs and PhD candidates. In the group, the post holder will be given the opportunity to supervise and mentor more junior scientists and visiting researchers. Furthermore, the post holder will have access to the Norwich Bioscience Institutes' extensive training programme and given the opportunity to enrol in training courses related to bioinformatics and career development. Continuous learning and improvement are expected. Key Relationships Evelien Adriaenssens (line manager) The post holder will work with other group members at the Adriaenssens group as well as other members of the Quadram Institute Bioscience. The post holder is expected to develop and maintain strong working relationships with the partners in the grant, in particular at the University of Lincoln, and with the Chinese partners working in parallel. Further key relationships are with members of the Quadram Science Voice, and members of the other research institutes of the Norwich Bioscience Institutes and the University of East Anglia. Main Activities & Responsibilities Percentage Establishment, maintenance and characterisation of bacteriophage collection for Salmonella 25 Development of resistant mutants of Salmonella and phenotypic characterisation 25 Bioinformatic analysis of Salmonella genomes in relation to AMR determinants, phage resistance and mobilisation 25 Dissemination of results through publication of scientific papers, media posts, and attending scientific conferences 15 Assist with supervising students and visiting workers in the group 5 As agreed with the line manager, any other duties commensurate with the nature of the post, for example, contributing to the work of Institute committees. 5 Person Profile Education & Qualifications Requirement Importance PhD in Microbiology, Biotechnology, Bioscience Engineering or a related Life Science subject (or equivalent experience) Essential Specialist Knowledge & Skills Requirement Importance Excellent microbiology laboratory skills Essential Microbiology techniques related to phage and/or bacteria culturing Essential Bioinformatics skills related to bacterial genomics Essential Proven record of publications appropriate with experience Essential Requirement Importance Laboratory experience in bacterial pathogen handling Essential Experience in molecular biology Essential Experience in working collaboratively Essential Experience in working with bacteriophages Desirable Interpersonal & Communication Skills Requirement Importance Good communication skills, both written and verbal Essential Good interpersonal skills, with the ability to work well as part of a team Essential Ability to work to deadlines Essential Ability to work and manage projects independently Essential Additional Requirements Requirement Importance Attention to detail Essential Embraces and promotes equity, diversity and inclusion in the workplace Essential Willingness to travel for project meetings Essential Willingness to embrace the expected values and behaviours of all staff at the Institute, ensuring it is a great place to work Essential Able to present a positive image of self and the Institute, promoting both the international reputation and public engagement aims of the Institute Essential Willingness to work outside standard working hours when required Essential Promotes equality and values diversity Essential Who We Are Quadram Institute Bioscience The Quadram Institute is at the forefront of a new interface between food science, gut biology and health, developing solutions to worldwide challenges in food-related disease and human health. We are engaged in fundamental and translational food and health research, alongside clinical studies, endoscopy and industry, working together to become a leading international hub for food and health research, combining scientific excellence and clinical expertise, delivering impacts on patient care and accelerating innovation. The Quadram Institute is a diverse and multicultural scientific community. We thrive on our international and European links, appointing staff from across the world. Any candidate who would like further information on current or anticipated immigration requirements can contact the HR Team on (0) or . The Adriaenssens group is a vibrant and collaborative research group looking into all things phage, consisting of three postdoctoral scientists and three PhD students. We use culture-dependent and independent approaches to understand the role of bacteriophages as part of a range of microbiomes, working both with single phage-host pairs and complex microbial communities. We have a strong interest in the use of bacteriophages as biocontrol agents for pathogenic bacteria. Research Scientist Applications are invited for a Research Scientist to join the Laboratory of Dr Evelien Adriaenssens in the Microbes and Food Safety programme at Quadram Institute Bioscience (QIB), based in Norwich, UK. Background: The Adriaenssens group is a vibrant and collaborative research group looking into all things phage. We use culture-dependent and independent approaches to understand the role of bacteriophages as part of a range of microbiomes, working both with single phage-host pairs and complex microbial communities. We have a strong interest in the use of bacteriophages as biocontrol agents for pathogenic bacteria. The role: As a Research Scientist on the MRC-funded project "Mechanism of multiple drug resistance and genetic evolution of prevalent Salmonella serotypes derived from animals", the post holder will contribute to the delivery of the objectives of the grant. Specifically, the post holder will investigate diverse Salmonella serovars across the food chain and the mechanisms of resistance development to bacteriophages and antibiotics. Key relationships will be developed with the Onarinde team at the University of Lincoln. The Research Scientist will help organise and attend project meetings and contribute to communication and dissemination of results, including presentation of findings at scientific conferences and the publication of papers. The post holder will be given the opportunity to enrol in training courses related to career development or technical skills, and will assist in the daily supervision of undergraduate and/or postgraduate students at QIB. The ideal candidate: The ideal candidate will hold a PhD in Microbiology, Biotechnology, Bioscience Engineering or a related Life Science subject (or expected to finish by post start) and is passionate about bacteriophages and food safety. The responsibilities will be split between laboratory work in phage and bacteria culturing, development of resistant mutants and genomics. The ideal candidate is therefore flexible and able to handle lab work and sequencing data in parallel. Good communications skills and the ability to coordinate with team members to deliver objectives are essential. Additional information: Salary on appointment will be within the range £36,720 to £39,750 per annum depending on qualifications and experience. This is a full-time post for a contract of 18 months. For further information and details of how to apply, please visit our website or contact the Human Resources team on or quoting reference . This role meets the criteria for a visa application, and we encourage all qualified candidates to apply. Please contact the Human Resources Team if you have any questions regarding your application or visa options. We are committed to equity, diversity and inclusion, and welcome applications from all sectors of society. The Institute values of Respect, Innovation, Collaboration and Excellence are at the heart of all we do, and we expect all employees to share and display these values. To support our commitment, we have a range of family, faith and diversity friendly working arrangements to help all staff achieve excellence in their area of work. As a Disability Confident employer, we guarantee to offer an interview to all disabled applicants who meet the essential criteria for this vacancy. About the Quadram Institute: . click apply for full job details
Postdoctoral Project Research Scientist (PPRS) About us The Francis Crick Institute is Europe's largest biomedical research institute under one roof. Our world-class scientists and staff collaborate on vital research to help prevent, diagnose and treat illnesses such as cancer, heart disease, infectious diseases and neurodegenerative conditions. The Crick is a place for collaboration, innovation and exploration across many disciplines. A space where the brightest minds can pursue big and bold ideas and discover answers to crucial scientific questions. We support them in a dynamic environment which fosters excellence with state-of-the-art infrastructure, cutting-edge facilities, and a creative and curious culture. We've removed traditional boundaries of departments, divisions and disciplines and instead have an open approach that supports every researcher. This gives us the freedom to collaborate and carry out high-quality, pioneering research. Creating a space for discovery without boundaries helps us to turn our science into benefits for human health and the economy. About the role The Miguel-Aliaga lab seek to understand how organs sense and react to their environment to maintain or change our physiology. To this end, they focus on the study of the intestinal tract; certain diets, microbes or internal states can cause it to grow or shrink. Current projects explore this plasticity across scales. Following previous work on the role that the shape of the gastrointestinal (GI) tract plays in health and disease in the fruit fly, we are now working on extending this work into analysis of human GI tract shape. We have adapted our methods to analyse GI tract shape in abdominal MRI scans and now wish to scale this up to a larger dataset. We have an approved project to work with the data of the UK Biobank - a large-scale biomedical database of volunteers from across the UK. This includes genetic data and whole-body MRI scans for 100,000 participants. We aim to investigate whether in humans, there is an underlying logic to GI tract shape and 3D organ arrangement which might vary in males and females, post-pregnancy and in disease such as Crohn's disease. We are looking for an ambitious and experienced image analyst for this computational post to develop AI-based image analysis methods to extract GI tract shape data from whole-body MRI scans. What you will be doing As a PPRS at the Crick, you will be: Developing image analysis tools for analysis of GI tract shape and volume from MRI scans Developing a neural network for the automation of segmentation of the GI tract from UK Biobank whole-body MRI scans Liaising with other lab members and collaborators to link analysis of GI tract shape features with other phenotype data and genetics in the UK Biobank Contributing to the preparation of scientific manuscripts, reports and presentations About you The essential criteria you will bring PhD in Developmental Biology, Cell Biology, Computational Biology or in the final stages of PhD submission Strong level of competence and experience of the use of deep learning for image analysis in large datasets, particularly image segmentation Strong level of competence in writing macros for ImageJ/FIJI and use of other languages such as R and Python for image analysis Experience of working with large 3D datasets such as MRI scans or microCT scans Experience of image segmentation Track record of writing papers as evidenced by publications or submitted manuscripts in refereed journals Evidence of data presentation at scientific meetings About Working at the Crick Our values Everyone who works at the Crick has a valuable role to play in advancing the Crick's mission and shaping our culture! We are bold. We make space for creative, dynamic and imaginative ideas and approaches. We're not afraid to do things differently. We are open. We're highly collaborative and interactive, and make sure our activities are visible to the outside world. We are collegial. We show respect for one another, work cooperatively and support the wider community. At the Francis Crick Institute, we believe that diversity and inclusion are essential to driving innovation and scientific discovery. We are committed to creating a workplace where everyone feels valued, respected, and empowered to succeed, regardless of their background, identity, or personal circumstances. We actively encourage applications from individuals of all genders, ethnicities, abilities, and experiences. We are a Disability Confident: Committed employer and you will be asked as part of the process if you wish to apply under the scheme. We will make reasonable adjustments if you need them. If you need assistance with applying (i.e., would like to apply by phone or post) please email: Please note that interviews for this role will take place from 02/07/25.
Jun 13, 2025
Full time
Postdoctoral Project Research Scientist (PPRS) About us The Francis Crick Institute is Europe's largest biomedical research institute under one roof. Our world-class scientists and staff collaborate on vital research to help prevent, diagnose and treat illnesses such as cancer, heart disease, infectious diseases and neurodegenerative conditions. The Crick is a place for collaboration, innovation and exploration across many disciplines. A space where the brightest minds can pursue big and bold ideas and discover answers to crucial scientific questions. We support them in a dynamic environment which fosters excellence with state-of-the-art infrastructure, cutting-edge facilities, and a creative and curious culture. We've removed traditional boundaries of departments, divisions and disciplines and instead have an open approach that supports every researcher. This gives us the freedom to collaborate and carry out high-quality, pioneering research. Creating a space for discovery without boundaries helps us to turn our science into benefits for human health and the economy. About the role The Miguel-Aliaga lab seek to understand how organs sense and react to their environment to maintain or change our physiology. To this end, they focus on the study of the intestinal tract; certain diets, microbes or internal states can cause it to grow or shrink. Current projects explore this plasticity across scales. Following previous work on the role that the shape of the gastrointestinal (GI) tract plays in health and disease in the fruit fly, we are now working on extending this work into analysis of human GI tract shape. We have adapted our methods to analyse GI tract shape in abdominal MRI scans and now wish to scale this up to a larger dataset. We have an approved project to work with the data of the UK Biobank - a large-scale biomedical database of volunteers from across the UK. This includes genetic data and whole-body MRI scans for 100,000 participants. We aim to investigate whether in humans, there is an underlying logic to GI tract shape and 3D organ arrangement which might vary in males and females, post-pregnancy and in disease such as Crohn's disease. We are looking for an ambitious and experienced image analyst for this computational post to develop AI-based image analysis methods to extract GI tract shape data from whole-body MRI scans. What you will be doing As a PPRS at the Crick, you will be: Developing image analysis tools for analysis of GI tract shape and volume from MRI scans Developing a neural network for the automation of segmentation of the GI tract from UK Biobank whole-body MRI scans Liaising with other lab members and collaborators to link analysis of GI tract shape features with other phenotype data and genetics in the UK Biobank Contributing to the preparation of scientific manuscripts, reports and presentations About you The essential criteria you will bring PhD in Developmental Biology, Cell Biology, Computational Biology or in the final stages of PhD submission Strong level of competence and experience of the use of deep learning for image analysis in large datasets, particularly image segmentation Strong level of competence in writing macros for ImageJ/FIJI and use of other languages such as R and Python for image analysis Experience of working with large 3D datasets such as MRI scans or microCT scans Experience of image segmentation Track record of writing papers as evidenced by publications or submitted manuscripts in refereed journals Evidence of data presentation at scientific meetings About Working at the Crick Our values Everyone who works at the Crick has a valuable role to play in advancing the Crick's mission and shaping our culture! We are bold. We make space for creative, dynamic and imaginative ideas and approaches. We're not afraid to do things differently. We are open. We're highly collaborative and interactive, and make sure our activities are visible to the outside world. We are collegial. We show respect for one another, work cooperatively and support the wider community. At the Francis Crick Institute, we believe that diversity and inclusion are essential to driving innovation and scientific discovery. We are committed to creating a workplace where everyone feels valued, respected, and empowered to succeed, regardless of their background, identity, or personal circumstances. We actively encourage applications from individuals of all genders, ethnicities, abilities, and experiences. We are a Disability Confident: Committed employer and you will be asked as part of the process if you wish to apply under the scheme. We will make reasonable adjustments if you need them. If you need assistance with applying (i.e., would like to apply by phone or post) please email: Please note that interviews for this role will take place from 02/07/25.
Scientist II, Bioinformatics page is loaded Scientist II, Bioinformatics Apply locations Edinburgh, UK time type Full time posted on Posted 4 Days Ago job requisition id R25-46 Asklepios BioPharmaceutical, Inc. (AskBio) is a leading, clinical-stage gene therapy company founded in 2001 based on the work of adeno-associated virus (AAV) gene therapy visionary and pioneer, Jude Samulski, PhD. Since that time, our commitment to developing life-saving medicines that can potentially cure genetic diseases has never wavered. At AskBio, we've built a foundation of therapeutic programs, AAV manufacturing and a rich portfolio of patented technology. Our therapeutic focus includes neuromuscular, central nervous system, cardiovascular and metabolic diseases with clinical trials underway for Pompe disease, Parkinson's disease, and congestive heart failure. Our gene therapy platform includes Pro10, an industry-leading proprietary cell line manufacturing process, and an extensive AAV capsid and promoter library. We became a wholly-owned, independently operated, subsidiary of Bayer AG in late 2020 as a cornerstone of its newly formed Cell & Gene Therapy (CGT) platform. Our global headquarters is in Research Triangle Park, NC. Additionally, we have significant operations in Philadelphia, PA, Columbus, OH, Scotland, France, Germany, and Spain. Our vision: Pioneering science to create transformative molecular medicines. Our mission: Lead innovative science and drive clinical outcomes to transform people's lives. Our principles: Advance innovative science by pushing boundaries. Bring transformative therapeutics to patients in need. Provide an environment for employees to reach their fullest potential. Our values: Be a Pioneer. We are not afraid of the impossible and to innovate to make gene therapies accessible to those in need. Cultivate Collaboration. Strive to be the best teammate, actively listen, openly communicate, and embrace diverse points of view. Embrace Responsibility. We are humbled by the enormity of our mission. We hold a relentless commitment to advance science and clinical outcomes for our patients, families, and caregivers. Raise the Bar. Continuously drive improvements and efficiencies. Seek and provide constructive feedback. Have a bias for learning and action. Act with Uncompromising Integrity. Be honest, transparent, and committed to doing what's right in every situation. Make clear commitments and follow through. Position Summary The Scientist II, Bioinformatics develops and implements computational methods for analysing proprietary biological data, supporting cross-functional teams with tailored bioinformatics solutions. Will have expertise in omics data analysis, statistical methods, and scientific programming. The role contributes to innovative computational research in gene therapy, advancing AskBio's platform-enabled product approach. This is a on-site based position in UK Edinburgh reporting to the Sr. Director, Bioinformatics and Machine Learning. Job Responsibilities Develop and implement computational methods and algorithms for the analysis of proprietary biological data. Collaborate with cross-functional international teams to understand data analysis needs and provide tailored bioinformatics solutions. Contribute to the design and optimisation of bioinformatics pipelines and workflows to improve data processing and analysis. Stay up to date with advancements in bioinformatics, machine learning, and data science, integrating relevant approaches into ongoing work. Communicate findings and recommendations effectively to stakeholders, including senior leadership and non-expert audiences. Provide mentorship and guidance to junior team members, fostering a culture of collaboration and learning. Minimum Requirements PhD in bioinformatics, computational biology, or a related discipline with at least 2+ years of postdoctoral or relevant industry experience; or Master's degree in bioinformatics, computational biology, or a related field with at least 8 years of relevant industry or research experience. Strong programming skills in Python. Experience in statistical analysis of DNA sequence and molecular datasets. Proven ability to communicate complex computational analyses to both technical and non-technical audience. Expertise in processing and analyzing omic datasets, particularly next-generation sequencing (NGS) data. Familiarity with Unix/Linux-based systems and command-line environments. Preferred Skills & Abilities Experience developing computational methods for biological data analysis. Experience working with clinical or translational research data. Proficiency in additional data analysis languages (e.g., R, MATLAB). Knowledge of containerization tools such as Docker. Familiarity with integrating multi-omics datasets. Experience with workflow management systems such as Snakemake or Nextflow. Knowledge of gene therapy and its bioinformatics challenges. Expertise in structural biology, particularly in protein structure modelling, interactions, and computational structural analysis. Experience contributing to cross-disciplinary and global research projects. Familiarity with version control systems (e.g., Git) and collaborative development practices.
Jun 13, 2025
Full time
Scientist II, Bioinformatics page is loaded Scientist II, Bioinformatics Apply locations Edinburgh, UK time type Full time posted on Posted 4 Days Ago job requisition id R25-46 Asklepios BioPharmaceutical, Inc. (AskBio) is a leading, clinical-stage gene therapy company founded in 2001 based on the work of adeno-associated virus (AAV) gene therapy visionary and pioneer, Jude Samulski, PhD. Since that time, our commitment to developing life-saving medicines that can potentially cure genetic diseases has never wavered. At AskBio, we've built a foundation of therapeutic programs, AAV manufacturing and a rich portfolio of patented technology. Our therapeutic focus includes neuromuscular, central nervous system, cardiovascular and metabolic diseases with clinical trials underway for Pompe disease, Parkinson's disease, and congestive heart failure. Our gene therapy platform includes Pro10, an industry-leading proprietary cell line manufacturing process, and an extensive AAV capsid and promoter library. We became a wholly-owned, independently operated, subsidiary of Bayer AG in late 2020 as a cornerstone of its newly formed Cell & Gene Therapy (CGT) platform. Our global headquarters is in Research Triangle Park, NC. Additionally, we have significant operations in Philadelphia, PA, Columbus, OH, Scotland, France, Germany, and Spain. Our vision: Pioneering science to create transformative molecular medicines. Our mission: Lead innovative science and drive clinical outcomes to transform people's lives. Our principles: Advance innovative science by pushing boundaries. Bring transformative therapeutics to patients in need. Provide an environment for employees to reach their fullest potential. Our values: Be a Pioneer. We are not afraid of the impossible and to innovate to make gene therapies accessible to those in need. Cultivate Collaboration. Strive to be the best teammate, actively listen, openly communicate, and embrace diverse points of view. Embrace Responsibility. We are humbled by the enormity of our mission. We hold a relentless commitment to advance science and clinical outcomes for our patients, families, and caregivers. Raise the Bar. Continuously drive improvements and efficiencies. Seek and provide constructive feedback. Have a bias for learning and action. Act with Uncompromising Integrity. Be honest, transparent, and committed to doing what's right in every situation. Make clear commitments and follow through. Position Summary The Scientist II, Bioinformatics develops and implements computational methods for analysing proprietary biological data, supporting cross-functional teams with tailored bioinformatics solutions. Will have expertise in omics data analysis, statistical methods, and scientific programming. The role contributes to innovative computational research in gene therapy, advancing AskBio's platform-enabled product approach. This is a on-site based position in UK Edinburgh reporting to the Sr. Director, Bioinformatics and Machine Learning. Job Responsibilities Develop and implement computational methods and algorithms for the analysis of proprietary biological data. Collaborate with cross-functional international teams to understand data analysis needs and provide tailored bioinformatics solutions. Contribute to the design and optimisation of bioinformatics pipelines and workflows to improve data processing and analysis. Stay up to date with advancements in bioinformatics, machine learning, and data science, integrating relevant approaches into ongoing work. Communicate findings and recommendations effectively to stakeholders, including senior leadership and non-expert audiences. Provide mentorship and guidance to junior team members, fostering a culture of collaboration and learning. Minimum Requirements PhD in bioinformatics, computational biology, or a related discipline with at least 2+ years of postdoctoral or relevant industry experience; or Master's degree in bioinformatics, computational biology, or a related field with at least 8 years of relevant industry or research experience. Strong programming skills in Python. Experience in statistical analysis of DNA sequence and molecular datasets. Proven ability to communicate complex computational analyses to both technical and non-technical audience. Expertise in processing and analyzing omic datasets, particularly next-generation sequencing (NGS) data. Familiarity with Unix/Linux-based systems and command-line environments. Preferred Skills & Abilities Experience developing computational methods for biological data analysis. Experience working with clinical or translational research data. Proficiency in additional data analysis languages (e.g., R, MATLAB). Knowledge of containerization tools such as Docker. Familiarity with integrating multi-omics datasets. Experience with workflow management systems such as Snakemake or Nextflow. Knowledge of gene therapy and its bioinformatics challenges. Expertise in structural biology, particularly in protein structure modelling, interactions, and computational structural analysis. Experience contributing to cross-disciplinary and global research projects. Familiarity with version control systems (e.g., Git) and collaborative development practices.
Lead AI Scientist - Small Molecule Discovery Cambridge, United Kingdom (Hybrid) Job Description Orion is seeking a visionary and technically exceptional Lead AI Scientist - Small Molecule Discovery to join our Molecular Prospecting and Modeling Unit. This newly established role is ideal for a scientist driven to push the boundaries of modern predictive and generative AI methods and redefine how small molecule drug discovery is conducted. If you're passionate about innovating beyond the current state-of-the-art and building transformative solutions that shape the future of drug design, we want to hear from you. We are on a bold digital transformation journey to redefine pharmaceutical R&D through the power of data, machine learning, and AI. As part of this mission, we are building a world-class digital R&D ecosystem that integrates scientific innovation with cutting-edge technology. We are paving our way to the future by transforming how we discover and design small molecule therapeutics, integrating computational methods with domain expertise in medicinal chemistry, biology, and pharmacology. Join us at the forefront of this transformation and help accelerate the discovery and development of new therapies for patients around the world. About your role As Lead AI Scientist, you will act as a thought leader in machine learning and artificial intelligence, spearheading the development of novel methodologies to enable data-driven hit discovery, hit-to-lead progression, and lead optimization. You will work alongside a highly experienced computational team and have a pivotal role in empowering scientists across Orion's R&D, including Medicinal Chemistry and DMPK-Tox experts. This role is not project-bound or service-oriented-it is about initiating a fundamental evolution in computational drug discovery at Orion. You will have a strong mandate to explore new technologies, implement cutting-edge solutions, and influence the strategic direction of AI-driven design. Your key responsibilities Developing and validating advanced AI/ML methodologies for molecular generation, prediction, and optimization. Designing and implementing scalable computational pipelines, models, and tools to be used by the broader modeling and cheminformatics team. Driving innovation in areas such as foundation models, active learning, and generative chemistry with attention to synthetic feasibility. Staying at the forefront of scientific and technical advances in AI for drug discovery. Collaborating with internal computational experts and external partners to extend Orion's capabilities. Contributing to scientific publications and participating in the broader scientific community where appropriate. This is a full-time position based in Cambridge, UK. In this position, you will report to the Head of Computational Design based in Espoo, Finland. What we offer At Orion, your work directly contributes to improving the lives of patients worldwide. We provide: A forward-looking, collaborative scientific environment with top-tier professionals. A unique opportunity to drive a technological leap in AI-powered drug discovery. Access to diverse chemical and biological data and modern compute environments. Opportunities for scientific publishing and engagement in external collaborations. Competitive salary, comprehensive health and welfare benefits, and support for international relocation. At Orion, your work creates true impact and well-being for our customers, patients, and society at large. Our culture of friendliness, respect, mutual appreciation, and diversity creates a safe working environment where you can strive for excellence. We offer a wealth of career paths and development opportunities that support the development of innovative solutions and improving the quality of life. Please visit our website for more information about our values and Orion as an employer: . To succeed in this role, we expect you to have: Ph.D. in machine learning, artificial intelligence, computational chemistry, cheminformatics, or a related field. 5+ years of postdoctoral experience. Proven track record in developing and applying modern AI/ML methods (e.g., generative models, GNNs, active learning, foundation models) in a scientific context. Strong coding skills and experience with relevant ML frameworks (e.g., PyTorch, TensorFlow, JAX) and chemistry toolkits (e.g., RDKit). Deep understanding of molecular representation techniques and their application in modeling. Experience in designing and implementing robust, scalable AI-driven workflows and tools. Passion for scientific discovery and the curiosity to explore new frontiers. Excellent communication and collaboration skills in a multidisciplinary environment. Fluent written and spoken English. Experience with organic and medicinal chemistry is highly valued, but deep domain expertise is not required. How to apply and additional information If this opportunity excites you, we encourage you to apply! Please submit your cover letter and CV by May 25th, 2025, and let us know what drives your passion for AI in small molecule discovery. Orion's pharmaceutical innovations are created within its R&D organization. We employ around 400 top professionals in the field of drug discovery and development. We work globally: in Espoo and Turku in Finland, in Nottingham in England, and in New York, NY, USA. Orion R&D and the Innovative Medicines business division are dedicated to making a transformation to become a global player in the pain and oncology therapy areas. Our Medicine Design Department plays a critical role in drug discovery, from target validation to clinical candidate nomination. The Molecular Prospecting and Modeling Unit defines hit-finding strategies for early-stage drug discovery and develops computational methods to support all stages of small molecule discovery. Our unit integrates cheminformatics, AI, molecular modeling, and structural biology to accelerate and guide data-driven drug design. About Us Orion is a globally operating Finnish pharmaceutical company - a builder of well-being for over a hundred years. Orion provides meaningful work for more than 3,600 Orionees in Finland and abroad. Orion is known as a responsible and reliable employer where we value each other, strive for the best, and build for tomorrow. We develop, manufacture, and market human and veterinary pharmaceuticals and active pharmaceutical ingredients. Orion has an extensive portfolio of proprietary and generic medicines and consumer health products. The core therapy areas of our pharmaceutical R&D are oncology and pain. Proprietary products developed by Orion are used to treat cancer, neurological diseases, and respiratory diseases, among others. Locations: The Bennett building B930 Babraham Research Campus, Cambridge, CB22 3AT, GB (Hybrid)
Jun 10, 2025
Full time
Lead AI Scientist - Small Molecule Discovery Cambridge, United Kingdom (Hybrid) Job Description Orion is seeking a visionary and technically exceptional Lead AI Scientist - Small Molecule Discovery to join our Molecular Prospecting and Modeling Unit. This newly established role is ideal for a scientist driven to push the boundaries of modern predictive and generative AI methods and redefine how small molecule drug discovery is conducted. If you're passionate about innovating beyond the current state-of-the-art and building transformative solutions that shape the future of drug design, we want to hear from you. We are on a bold digital transformation journey to redefine pharmaceutical R&D through the power of data, machine learning, and AI. As part of this mission, we are building a world-class digital R&D ecosystem that integrates scientific innovation with cutting-edge technology. We are paving our way to the future by transforming how we discover and design small molecule therapeutics, integrating computational methods with domain expertise in medicinal chemistry, biology, and pharmacology. Join us at the forefront of this transformation and help accelerate the discovery and development of new therapies for patients around the world. About your role As Lead AI Scientist, you will act as a thought leader in machine learning and artificial intelligence, spearheading the development of novel methodologies to enable data-driven hit discovery, hit-to-lead progression, and lead optimization. You will work alongside a highly experienced computational team and have a pivotal role in empowering scientists across Orion's R&D, including Medicinal Chemistry and DMPK-Tox experts. This role is not project-bound or service-oriented-it is about initiating a fundamental evolution in computational drug discovery at Orion. You will have a strong mandate to explore new technologies, implement cutting-edge solutions, and influence the strategic direction of AI-driven design. Your key responsibilities Developing and validating advanced AI/ML methodologies for molecular generation, prediction, and optimization. Designing and implementing scalable computational pipelines, models, and tools to be used by the broader modeling and cheminformatics team. Driving innovation in areas such as foundation models, active learning, and generative chemistry with attention to synthetic feasibility. Staying at the forefront of scientific and technical advances in AI for drug discovery. Collaborating with internal computational experts and external partners to extend Orion's capabilities. Contributing to scientific publications and participating in the broader scientific community where appropriate. This is a full-time position based in Cambridge, UK. In this position, you will report to the Head of Computational Design based in Espoo, Finland. What we offer At Orion, your work directly contributes to improving the lives of patients worldwide. We provide: A forward-looking, collaborative scientific environment with top-tier professionals. A unique opportunity to drive a technological leap in AI-powered drug discovery. Access to diverse chemical and biological data and modern compute environments. Opportunities for scientific publishing and engagement in external collaborations. Competitive salary, comprehensive health and welfare benefits, and support for international relocation. At Orion, your work creates true impact and well-being for our customers, patients, and society at large. Our culture of friendliness, respect, mutual appreciation, and diversity creates a safe working environment where you can strive for excellence. We offer a wealth of career paths and development opportunities that support the development of innovative solutions and improving the quality of life. Please visit our website for more information about our values and Orion as an employer: . To succeed in this role, we expect you to have: Ph.D. in machine learning, artificial intelligence, computational chemistry, cheminformatics, or a related field. 5+ years of postdoctoral experience. Proven track record in developing and applying modern AI/ML methods (e.g., generative models, GNNs, active learning, foundation models) in a scientific context. Strong coding skills and experience with relevant ML frameworks (e.g., PyTorch, TensorFlow, JAX) and chemistry toolkits (e.g., RDKit). Deep understanding of molecular representation techniques and their application in modeling. Experience in designing and implementing robust, scalable AI-driven workflows and tools. Passion for scientific discovery and the curiosity to explore new frontiers. Excellent communication and collaboration skills in a multidisciplinary environment. Fluent written and spoken English. Experience with organic and medicinal chemistry is highly valued, but deep domain expertise is not required. How to apply and additional information If this opportunity excites you, we encourage you to apply! Please submit your cover letter and CV by May 25th, 2025, and let us know what drives your passion for AI in small molecule discovery. Orion's pharmaceutical innovations are created within its R&D organization. We employ around 400 top professionals in the field of drug discovery and development. We work globally: in Espoo and Turku in Finland, in Nottingham in England, and in New York, NY, USA. Orion R&D and the Innovative Medicines business division are dedicated to making a transformation to become a global player in the pain and oncology therapy areas. Our Medicine Design Department plays a critical role in drug discovery, from target validation to clinical candidate nomination. The Molecular Prospecting and Modeling Unit defines hit-finding strategies for early-stage drug discovery and develops computational methods to support all stages of small molecule discovery. Our unit integrates cheminformatics, AI, molecular modeling, and structural biology to accelerate and guide data-driven drug design. About Us Orion is a globally operating Finnish pharmaceutical company - a builder of well-being for over a hundred years. Orion provides meaningful work for more than 3,600 Orionees in Finland and abroad. Orion is known as a responsible and reliable employer where we value each other, strive for the best, and build for tomorrow. We develop, manufacture, and market human and veterinary pharmaceuticals and active pharmaceutical ingredients. Orion has an extensive portfolio of proprietary and generic medicines and consumer health products. The core therapy areas of our pharmaceutical R&D are oncology and pain. Proprietary products developed by Orion are used to treat cancer, neurological diseases, and respiratory diseases, among others. Locations: The Bennett building B930 Babraham Research Campus, Cambridge, CB22 3AT, GB (Hybrid)
About Us The Francis Crick Institute is Europe's largest biomedical research institute under one roof. Our world-class scientists and staff collaborate on vital research to help prevent, diagnose and treat illnesses such as cancer, heart disease, infectious diseases and neurodegenerative conditions. The Crick is a place for collaboration, innovation and exploration across many disciplines. A space where the brightest minds can pursue big and bold ideas and discover answers to crucial scientific questions. We support them in a dynamic environment which fosters excellence with state-of-the-art infrastructure, cutting-edge facilities, and a creative and curious culture. We've removed traditional boundaries of departments, divisions and disciplines and instead have an open approach that supports every researcher. This gives us the freedom to collaborate and carry out high-quality, pioneering research. Creating a space for discovery without boundaries helps us to turn our science into benefits for human health and the economy. The Research Group The Developmental Signalling Laboratory headed by Caroline Hill focuses on cell signalling in early vertebrate development and disease. Their work seeks to understand how TGF-b family signalling pathways function normally in early vertebrate development and in adult untransformed cells, and how these signalling pathways are perturbed in disease, in particular in cancer and the Marfan-related syndromes. Work in the Hill laboratory exploits the very powerful combination of early vertebrate developmental systems (zebrafish embryos), together with a variety of model tissue culture systems (human and mouse ES cell/iPS cell models), and mouse cancer models and uses a very wide range of methodologies including developmental and cell biology, cancer biology, next generation sequencing and computational modelling. The Hill lab encourages creative and independent thinking and promotes excellent training and mentoring. The group currently comprises ten people - five postdocs, two PhD students, a clinical fellow, a master's student and a senior laboratory research scientist. The Project Recent work in my lab has determined that mesoderm and endoderm specification in zebrafish embryos requires the interplay of two signalling pathways, Nodal and Fgf/Erk. We have shown that the distribution of endodermal progenitors results from a stochastic process where sustained Nodal signalling provides a competency window for the switching of bipotential progenitors to an endodermal fate. Switching is apparently stochastic and is inhibited by Fgf/Erk signalling. Cells that do not switch to the endodermal fate, differentiate to mesoderm. Thus, we hypothesise that short windows of Erk inactivity govern the switching to the endodermal fate and we have shown that these occur as cells undergo mitosis as a result of a phenomenon we are calling mitotic erasure. We now want to understand whether a similar mechanism controls the cell fate decision between mesoderm and definitive endoderm in humans, and if not, how this fate decision is controlled. To undertake this work, I am looking for a highly motivated postdoc with proven research abilities and an excellent publication record. The project will make use of human embryonic stem cells (hESCs) differentiated as 2D and 3D gastruloids. We will multiplex our novel Erk biosensor with live cell fate reporters to discover whether and how Erk signalling is involved in the cell fate decision between definitive endoderm and mesoderm. Furthermore, we will use multiomics scRNA-seq and scATAC-seq methodology, as well as whole genome CRISPR screening approaches to gain unbiased new insights into the mechanisms driving the specification of the mesodermal and endodermal lineages in humans. Postdoctoral Fellows at the Crick lead their own projects, contribute to other projects on a collaborative basis (both in the lab and with external collaborators) and may guide PhD students in their research. The ability to work in a team is essential. Key experience and competencies Essential PhD in a relevant biological science Excellent knowledge and demonstrable practical experience of working with embryonic stem cells Extensive technical expertise in differentiating embryonic stem cells to different tissue types as 2D and 3D gastruloids Technical expertise in advanced live imaging Technical expertise in molecular biology Excellent track record of writing papers as evidenced by publications or submitted manuscripts in referred journals Evidence of data presentation at scientific meetings as talks and posters Strong organisational skills and thorough record-keeping Ability to work independently and also in a team Desirable Experience in 'omics techniques and bioinformatic analysis Experience in signal transduction research About Working at the Crick Our values Everyone who works at the Crick has a valuable role to play in advancing the Crick's mission and shaping our culture! We are bold . We make space for creative, dynamic and imaginative ideas and approaches. We're not afraid to do things differently. We are open . We're highly collaborative and interactive, and make sure our activities are visible to the outside world. We are collegial . We show respect for one another, work cooperatively and support the wider community. At the Francis Crick Institute, we believe that diversity and inclusion are essential to driving innovation and scientific discovery. We are committed to creating a workplace where everyone feels valued, respected, and empowered to succeed, regardless of their background, identity, or personal circumstances. We actively encourage applications from individuals of all genders, ethnicities, abilities, and experiences. We want to ensure that everyone can apply and be part of our team and you will be asked as part of the process if you wish to apply under the Disability Confident scheme. We will make reasonable adjustments if you need them. If you need assistance with applying (i.e., would like to apply by phone or post) please email: To find out more about life at the Crick click here. What will you receive? At the Francis Crick Institute, we value our team members and are proud to offer an extensive range of benefits to support their well-being and development: Visas: Applicants for this role will be eligible for sponsorship to work in the UK, which the CRICK will fully fund for individuals and dependents. Generous Leave : 28 days of annual leave, plus three additional days over Christmas and bank holidays. Pension Scheme : Defined contribution pension with employer contributions of up to 16%. 24/7 GP consultation services. Occupational health services and mental health support programs. Eye care vouchers and discounted healthcare plans. Work-Life Balance : Childcare support allowance. Annual leave purchase options. Crick Networks offering diverse groups' support, community and inclusive social events. Discounted gym memberships, bike-to-work scheme, and shopping discounts. Subsidised on-site restaurant and social spaces for team interaction. Development & Recognition : Comprehensive training, mentoring, and a pay structure based on skills and experience.
Jun 09, 2025
Full time
About Us The Francis Crick Institute is Europe's largest biomedical research institute under one roof. Our world-class scientists and staff collaborate on vital research to help prevent, diagnose and treat illnesses such as cancer, heart disease, infectious diseases and neurodegenerative conditions. The Crick is a place for collaboration, innovation and exploration across many disciplines. A space where the brightest minds can pursue big and bold ideas and discover answers to crucial scientific questions. We support them in a dynamic environment which fosters excellence with state-of-the-art infrastructure, cutting-edge facilities, and a creative and curious culture. We've removed traditional boundaries of departments, divisions and disciplines and instead have an open approach that supports every researcher. This gives us the freedom to collaborate and carry out high-quality, pioneering research. Creating a space for discovery without boundaries helps us to turn our science into benefits for human health and the economy. The Research Group The Developmental Signalling Laboratory headed by Caroline Hill focuses on cell signalling in early vertebrate development and disease. Their work seeks to understand how TGF-b family signalling pathways function normally in early vertebrate development and in adult untransformed cells, and how these signalling pathways are perturbed in disease, in particular in cancer and the Marfan-related syndromes. Work in the Hill laboratory exploits the very powerful combination of early vertebrate developmental systems (zebrafish embryos), together with a variety of model tissue culture systems (human and mouse ES cell/iPS cell models), and mouse cancer models and uses a very wide range of methodologies including developmental and cell biology, cancer biology, next generation sequencing and computational modelling. The Hill lab encourages creative and independent thinking and promotes excellent training and mentoring. The group currently comprises ten people - five postdocs, two PhD students, a clinical fellow, a master's student and a senior laboratory research scientist. The Project Recent work in my lab has determined that mesoderm and endoderm specification in zebrafish embryos requires the interplay of two signalling pathways, Nodal and Fgf/Erk. We have shown that the distribution of endodermal progenitors results from a stochastic process where sustained Nodal signalling provides a competency window for the switching of bipotential progenitors to an endodermal fate. Switching is apparently stochastic and is inhibited by Fgf/Erk signalling. Cells that do not switch to the endodermal fate, differentiate to mesoderm. Thus, we hypothesise that short windows of Erk inactivity govern the switching to the endodermal fate and we have shown that these occur as cells undergo mitosis as a result of a phenomenon we are calling mitotic erasure. We now want to understand whether a similar mechanism controls the cell fate decision between mesoderm and definitive endoderm in humans, and if not, how this fate decision is controlled. To undertake this work, I am looking for a highly motivated postdoc with proven research abilities and an excellent publication record. The project will make use of human embryonic stem cells (hESCs) differentiated as 2D and 3D gastruloids. We will multiplex our novel Erk biosensor with live cell fate reporters to discover whether and how Erk signalling is involved in the cell fate decision between definitive endoderm and mesoderm. Furthermore, we will use multiomics scRNA-seq and scATAC-seq methodology, as well as whole genome CRISPR screening approaches to gain unbiased new insights into the mechanisms driving the specification of the mesodermal and endodermal lineages in humans. Postdoctoral Fellows at the Crick lead their own projects, contribute to other projects on a collaborative basis (both in the lab and with external collaborators) and may guide PhD students in their research. The ability to work in a team is essential. Key experience and competencies Essential PhD in a relevant biological science Excellent knowledge and demonstrable practical experience of working with embryonic stem cells Extensive technical expertise in differentiating embryonic stem cells to different tissue types as 2D and 3D gastruloids Technical expertise in advanced live imaging Technical expertise in molecular biology Excellent track record of writing papers as evidenced by publications or submitted manuscripts in referred journals Evidence of data presentation at scientific meetings as talks and posters Strong organisational skills and thorough record-keeping Ability to work independently and also in a team Desirable Experience in 'omics techniques and bioinformatic analysis Experience in signal transduction research About Working at the Crick Our values Everyone who works at the Crick has a valuable role to play in advancing the Crick's mission and shaping our culture! We are bold . We make space for creative, dynamic and imaginative ideas and approaches. We're not afraid to do things differently. We are open . We're highly collaborative and interactive, and make sure our activities are visible to the outside world. We are collegial . We show respect for one another, work cooperatively and support the wider community. At the Francis Crick Institute, we believe that diversity and inclusion are essential to driving innovation and scientific discovery. We are committed to creating a workplace where everyone feels valued, respected, and empowered to succeed, regardless of their background, identity, or personal circumstances. We actively encourage applications from individuals of all genders, ethnicities, abilities, and experiences. We want to ensure that everyone can apply and be part of our team and you will be asked as part of the process if you wish to apply under the Disability Confident scheme. We will make reasonable adjustments if you need them. If you need assistance with applying (i.e., would like to apply by phone or post) please email: To find out more about life at the Crick click here. What will you receive? At the Francis Crick Institute, we value our team members and are proud to offer an extensive range of benefits to support their well-being and development: Visas: Applicants for this role will be eligible for sponsorship to work in the UK, which the CRICK will fully fund for individuals and dependents. Generous Leave : 28 days of annual leave, plus three additional days over Christmas and bank holidays. Pension Scheme : Defined contribution pension with employer contributions of up to 16%. 24/7 GP consultation services. Occupational health services and mental health support programs. Eye care vouchers and discounted healthcare plans. Work-Life Balance : Childcare support allowance. Annual leave purchase options. Crick Networks offering diverse groups' support, community and inclusive social events. Discounted gym memberships, bike-to-work scheme, and shopping discounts. Subsidised on-site restaurant and social spaces for team interaction. Development & Recognition : Comprehensive training, mentoring, and a pay structure based on skills and experience.
We are looking for an advanced chemist to join our team to train AI models. You will measure the progress of these AI chatbots, evaluate their logic, and solve problems to improve the quality of each model. In this role you will need to hold an expert understanding of chemistry- a completed or in progress Masters/PhD is preferred but not required. Other related fields include, but are not limited to: Formulation Scientist, Development Chemist, Analytical Chemist, Chemical Engineer, Medicinal Chemist, Biochemist, Process Development Chemist. Benefits: This is a full-time or part-time REMOTE position You'll be able to choose which projects you want to work on You can work on your own schedule Projects are paid hourly starting at $40+ USD per hour, with bonuses on high-quality and high-volume work Responsibilities: Give AI chatbots diverse and complex chemistry problems and evaluate their outputs Evaluate the quality produced by AI models for correctness and performance Qualifications: A current, in progress, or completed Masters and/or PhD is preferred but not required Fluency in English (native or bilingual level) Detail-oriented Proficient in chemistry and inductive/deductive reasoning, physical/temporal/ spatial reasoning Note: Payment is made via PayPal. We will never ask for any money from you. PayPal will handle any currency conversions from USD. Job Types: Full-time, Part-time Pay: From £29.51 per hour Work Location: Remote
Jun 09, 2025
Full time
We are looking for an advanced chemist to join our team to train AI models. You will measure the progress of these AI chatbots, evaluate their logic, and solve problems to improve the quality of each model. In this role you will need to hold an expert understanding of chemistry- a completed or in progress Masters/PhD is preferred but not required. Other related fields include, but are not limited to: Formulation Scientist, Development Chemist, Analytical Chemist, Chemical Engineer, Medicinal Chemist, Biochemist, Process Development Chemist. Benefits: This is a full-time or part-time REMOTE position You'll be able to choose which projects you want to work on You can work on your own schedule Projects are paid hourly starting at $40+ USD per hour, with bonuses on high-quality and high-volume work Responsibilities: Give AI chatbots diverse and complex chemistry problems and evaluate their outputs Evaluate the quality produced by AI models for correctness and performance Qualifications: A current, in progress, or completed Masters and/or PhD is preferred but not required Fluency in English (native or bilingual level) Detail-oriented Proficient in chemistry and inductive/deductive reasoning, physical/temporal/ spatial reasoning Note: Payment is made via PayPal. We will never ask for any money from you. PayPal will handle any currency conversions from USD. Job Types: Full-time, Part-time Pay: From £29.51 per hour Work Location: Remote
We are looking for an advanced chemist to join our team to train AI models. You will measure the progress of these AI chatbots, evaluate their logic, and solve problems to improve the quality of each model. In this role you will need to hold an expert understanding of chemistry- a completed or in progress Masters/PhD is preferred but not required. Other related fields include, but are not limited to: Formulation Scientist, Development Chemist, Analytical Chemist, Chemical Engineer, Medicinal Chemist, Biochemist, Process Development Chemist. Benefits: This is a full-time or part-time REMOTE position You'll be able to choose which projects you want to work on You can work on your own schedule Projects are paid hourly starting at $40+ USD per hour, with bonuses on high-quality and high-volume work Responsibilities: Give AI chatbots diverse and complex chemistry problems and evaluate their outputs Evaluate the quality produced by AI models for correctness and performance Qualifications: A current, in progress, or completed Masters and/or PhD is preferred but not required Fluency in English (native or bilingual level) Detail-oriented Proficient in chemistry and inductive/deductive reasoning, physical/temporal/ spatial reasoning Note: Payment is made via PayPal. We will never ask for any money from you. PayPal will handle any currency conversions from USD. Job Types: Full-time, Part-time Pay: From £29.72 per hour Work Location: Remote
Jun 08, 2025
Full time
We are looking for an advanced chemist to join our team to train AI models. You will measure the progress of these AI chatbots, evaluate their logic, and solve problems to improve the quality of each model. In this role you will need to hold an expert understanding of chemistry- a completed or in progress Masters/PhD is preferred but not required. Other related fields include, but are not limited to: Formulation Scientist, Development Chemist, Analytical Chemist, Chemical Engineer, Medicinal Chemist, Biochemist, Process Development Chemist. Benefits: This is a full-time or part-time REMOTE position You'll be able to choose which projects you want to work on You can work on your own schedule Projects are paid hourly starting at $40+ USD per hour, with bonuses on high-quality and high-volume work Responsibilities: Give AI chatbots diverse and complex chemistry problems and evaluate their outputs Evaluate the quality produced by AI models for correctness and performance Qualifications: A current, in progress, or completed Masters and/or PhD is preferred but not required Fluency in English (native or bilingual level) Detail-oriented Proficient in chemistry and inductive/deductive reasoning, physical/temporal/ spatial reasoning Note: Payment is made via PayPal. We will never ask for any money from you. PayPal will handle any currency conversions from USD. Job Types: Full-time, Part-time Pay: From £29.72 per hour Work Location: Remote
This is a full-time, 1-year fixed-term position on Crick terms and conditions of employment. Summary The Quantitative Stem Cell Biology lab, headed by Dr. Silvia Santos, is seeking a Senior Laboratory Research Scientist (SLRS). The successful candidate will investigate the spatio-temporal control of cell division and cell cycle remodelling during cellular differentiation using 2D and 3D stem cell-based models of human gastrulation. The postholder will lead a research project and contribute to collaborative projects within the lab. They will benefit from excellent mentorship and training within a vibrant, collegial scientific community at the Santos lab and the Francis Crick Institute. The research group The Quantitative Stem Cell Biology lab, established in 2018 at the Francis Crick Institute, focuses on understanding cell decision-making. Current research includes regulatory mechanisms of cell fate specification, cell cycle remodeling during differentiation, and the interplay between metabolism, cell cycle, and cell fate. The lab emphasizes single-cell analysis and advanced live-cell imaging, using models such as mouse and human embryonic stem cells (ESC), 3D organoids, and mouse embryos. The team is multidisciplinary, diverse, and includes PhD students, postdoctoral fellows, and a principal research scientist. The lab promotes independent, creative thinking and provides excellent training and mentorship. Key responsibilities Lead specific research projects under the supervision of the Group Leader. Attend and participate in group meetings and seminars. Maintain accurate records of all work. Train junior colleagues as appropriate. Contribute to scientific manuscript preparation. Participate in the lab hESC feeding rota. Foster a positive and motivating lab environment. Key experience and competencies The candidate should embody the Crick values: bold, imaginative, open, dynamic, and collegial, alongside the following: Essential qualifications, experience, and competencies: PhD in a relevant Life Sciences area. Extensive experience in Molecular Biology. Experience with cell culture techniques. Experience with imaging/microscopy. Motivation and/or experience in understanding cell division in development and/or disease. Excellent organizational skills, including meticulous record-keeping. Strong interpersonal skills for effective collaboration. Proven ability to work independently, contributing to publications. Desirable qualifications, experience, and competencies: Experience with stem cell culture, particularly hESCs/iPSCs. Prior experience with image analysis. Analytical mindset. Track record of publishing scientific papers. The position will close once an appropriate candidate is found. We encourage early application.
Jun 08, 2025
Full time
This is a full-time, 1-year fixed-term position on Crick terms and conditions of employment. Summary The Quantitative Stem Cell Biology lab, headed by Dr. Silvia Santos, is seeking a Senior Laboratory Research Scientist (SLRS). The successful candidate will investigate the spatio-temporal control of cell division and cell cycle remodelling during cellular differentiation using 2D and 3D stem cell-based models of human gastrulation. The postholder will lead a research project and contribute to collaborative projects within the lab. They will benefit from excellent mentorship and training within a vibrant, collegial scientific community at the Santos lab and the Francis Crick Institute. The research group The Quantitative Stem Cell Biology lab, established in 2018 at the Francis Crick Institute, focuses on understanding cell decision-making. Current research includes regulatory mechanisms of cell fate specification, cell cycle remodeling during differentiation, and the interplay between metabolism, cell cycle, and cell fate. The lab emphasizes single-cell analysis and advanced live-cell imaging, using models such as mouse and human embryonic stem cells (ESC), 3D organoids, and mouse embryos. The team is multidisciplinary, diverse, and includes PhD students, postdoctoral fellows, and a principal research scientist. The lab promotes independent, creative thinking and provides excellent training and mentorship. Key responsibilities Lead specific research projects under the supervision of the Group Leader. Attend and participate in group meetings and seminars. Maintain accurate records of all work. Train junior colleagues as appropriate. Contribute to scientific manuscript preparation. Participate in the lab hESC feeding rota. Foster a positive and motivating lab environment. Key experience and competencies The candidate should embody the Crick values: bold, imaginative, open, dynamic, and collegial, alongside the following: Essential qualifications, experience, and competencies: PhD in a relevant Life Sciences area. Extensive experience in Molecular Biology. Experience with cell culture techniques. Experience with imaging/microscopy. Motivation and/or experience in understanding cell division in development and/or disease. Excellent organizational skills, including meticulous record-keeping. Strong interpersonal skills for effective collaboration. Proven ability to work independently, contributing to publications. Desirable qualifications, experience, and competencies: Experience with stem cell culture, particularly hESCs/iPSCs. Prior experience with image analysis. Analytical mindset. Track record of publishing scientific papers. The position will close once an appropriate candidate is found. We encourage early application.
Details of the role: This is a full-time, fixed-term (two years) position on Crick terms and conditions of employment. About us The Francis Crick Institute is Europe's largest biomedical research institute under one roof. Our world-class scientists and staff collaborate on vital research to help prevent, diagnose, and treat illnesses such as cancer, heart disease, infectious diseases, and neurodegenerative conditions. The Crick is a place for collaboration, innovation, and exploration across many disciplines. A space where the brightest minds can pursue big and bold ideas and discover answers to crucial scientific questions. We support them in a dynamic environment which fosters excellence with state-of-the-art infrastructure, cutting-edge facilities, and a creative and curious culture. We've removed traditional boundaries of departments, divisions, and disciplines and instead have an open approach that supports every researcher. This gives us the freedom to take risks and carry out high-quality, pioneering research. Creating a space for discovery without boundaries helps us to turn our science into benefits for human health and the economy. About the role We are seeking an experienced Postdoctoral Project Research Scientist to join our team. In this role, you will both lead your own independent project(s) and contribute to the development of innovative tools and technologies that advance the lab's research program. You will be part of a collaborative and diverse group dedicated to uncovering how a functional, beating heart is formed during development. Your work will involve applying in-depth technical expertise in cutting-edge imaging technologies, image analysis techniques, and biophysical approaches. The specific goals and direction of the project(s) will be shaped in close consultation with the supervisor and tailored to your background and interests. The heart is the first organ to form and function during embryonic development. A key step during vertebrate heart development is chamber maturation - a poorly-understood morphogenetic process critical for heart function. During this process, the myocardial wall of the ventricle and atrium transforms from a single-layered epithelium into a complex 3D topological meshwork architecture (Priya et al., 2021, Nature; bioRxiv 2024.07.24.604962; bioRxiv, 2025.03.07.641942). How this topological complexity is achieved is unknown, as are the underlying mechanisms that shape these crucial anatomical structures. In our lab, we aim to unravel the underlying mechanical, molecular, and geometric interactions that transform a developing heart from a simple epithelium into a highly intricate functional organ. We combine the excellent tractability of zebrafish embryos with quantitative imaging, transcriptomics, biophysics, genetics, and predictive theoretical modelling to answer fundamental questions driving organ morphogenesis. What you will be doing: As a PPRS you will: Develop and establish new tools and techniques - advanced 4D live imaging of zebrafish hearts, image analysis pipelines, biophysical methods for measuring mechanical forces, and gene-editing tools. Conceptualize and lead research project(s) Provide expert guidance and technical support to lab members, fostering knowledge exchange and skill development. Contribute to other projects on a collaborative basis, both in the lab and with external collaborators. Actively contribute to the development and publication of scientific manuscripts Help cultivate a collaborative, inclusive, and intellectually stimulating lab environment. About you You will bring PhD (or near completion) in cell biology, developmental biology, or biophysics. Proven expertise in advanced confocal and light-sheet microscopy, as shown by publications. Excellent skills in molecular biology. Experience in embryological techniques (zebrafish/fly/mouse) as well as gene editing methods. Demonstrated ability to write scientific papers, as shown by publications and/or preprints in relevant fields.
Jun 08, 2025
Full time
Details of the role: This is a full-time, fixed-term (two years) position on Crick terms and conditions of employment. About us The Francis Crick Institute is Europe's largest biomedical research institute under one roof. Our world-class scientists and staff collaborate on vital research to help prevent, diagnose, and treat illnesses such as cancer, heart disease, infectious diseases, and neurodegenerative conditions. The Crick is a place for collaboration, innovation, and exploration across many disciplines. A space where the brightest minds can pursue big and bold ideas and discover answers to crucial scientific questions. We support them in a dynamic environment which fosters excellence with state-of-the-art infrastructure, cutting-edge facilities, and a creative and curious culture. We've removed traditional boundaries of departments, divisions, and disciplines and instead have an open approach that supports every researcher. This gives us the freedom to take risks and carry out high-quality, pioneering research. Creating a space for discovery without boundaries helps us to turn our science into benefits for human health and the economy. About the role We are seeking an experienced Postdoctoral Project Research Scientist to join our team. In this role, you will both lead your own independent project(s) and contribute to the development of innovative tools and technologies that advance the lab's research program. You will be part of a collaborative and diverse group dedicated to uncovering how a functional, beating heart is formed during development. Your work will involve applying in-depth technical expertise in cutting-edge imaging technologies, image analysis techniques, and biophysical approaches. The specific goals and direction of the project(s) will be shaped in close consultation with the supervisor and tailored to your background and interests. The heart is the first organ to form and function during embryonic development. A key step during vertebrate heart development is chamber maturation - a poorly-understood morphogenetic process critical for heart function. During this process, the myocardial wall of the ventricle and atrium transforms from a single-layered epithelium into a complex 3D topological meshwork architecture (Priya et al., 2021, Nature; bioRxiv 2024.07.24.604962; bioRxiv, 2025.03.07.641942). How this topological complexity is achieved is unknown, as are the underlying mechanisms that shape these crucial anatomical structures. In our lab, we aim to unravel the underlying mechanical, molecular, and geometric interactions that transform a developing heart from a simple epithelium into a highly intricate functional organ. We combine the excellent tractability of zebrafish embryos with quantitative imaging, transcriptomics, biophysics, genetics, and predictive theoretical modelling to answer fundamental questions driving organ morphogenesis. What you will be doing: As a PPRS you will: Develop and establish new tools and techniques - advanced 4D live imaging of zebrafish hearts, image analysis pipelines, biophysical methods for measuring mechanical forces, and gene-editing tools. Conceptualize and lead research project(s) Provide expert guidance and technical support to lab members, fostering knowledge exchange and skill development. Contribute to other projects on a collaborative basis, both in the lab and with external collaborators. Actively contribute to the development and publication of scientific manuscripts Help cultivate a collaborative, inclusive, and intellectually stimulating lab environment. About you You will bring PhD (or near completion) in cell biology, developmental biology, or biophysics. Proven expertise in advanced confocal and light-sheet microscopy, as shown by publications. Excellent skills in molecular biology. Experience in embryological techniques (zebrafish/fly/mouse) as well as gene editing methods. Demonstrated ability to write scientific papers, as shown by publications and/or preprints in relevant fields.
Postdoctoral Researcher (Foraminifera Geochemist) Postdoc Researcher Scroll down to read more: Rehemat Job title: Postdoctoral Researcher - Foraminifera Geochemist What does a Foraminifera Geochemist do? I am a hybrid micropalaeontologist and geochemist. A micropalaeontologist studies microscopic fossils, and a geochemist analyses the chemistry of geological materials. I use the chemistry of fossil species of foraminifera, a type of plankton with a calcium carbonate skeleton, to understand more about their ecologies and climate millions of years ago (palaeoclimatology). Different chemical elements can help me understand how hot the oceans were, whether some species of plankton lived closer to the surface of the ocean or further down in the water column, and even how much ice there was on land! I wash sediment samples, identify the plankton hiding inside, then analyse them for their chemistry and try to understand the data they produce. What formal qualifications and previous work experience did you need to get your job? When I was a teenager I did some work experience at the Natural History Museum, London and The Royal Geographical Society. Having had a super positive introduction to Earth Sciences through these experiences, I decided to do an undergraduate MSci degree in Geoscience at Royal Holloway (University of London). During my undergraduate degree I did several internships. I interned at a structural geology company, biostratigraphy company and a summer research internship focused around foraminifera and palaeoclimatology working with a PhD student in Kiel, Germany. I also volunteered at the Natural History Museum throughout the final years of my undergraduate degree. These last two experiences made me realise I could combine my love of geochemistry and ocean sciences, and I subsequently decided to do a PhD at University College London. What other skills or characteristics do you need in your job? Always be curious Always be persistent Understand how to communicate your science to non-specialists in an enthusiastic way Have good attention to detail for taxonomy Know the importance of collaboration and networking. You never know when your mass spectrometer will break and you will need to contact another lab to use their instrument! What sort of organisation do you work for? Where else could you work as a Foraminifera Geochemist? I work at a university, but those with my background can also work in many different sectors, including the oil industry (as a biostratigrapher, using foraminfera to date rock formations), analytical instrument companies, science policy and publishers. Science communication is also popular, but this is definitely applicable as a career path across geological facets! Working in the third sector (i.e. with charities and NGOs) within Trusts and Foundations/Major Donor Fundraising is also possible, because all researchers have the ability to network, collaborate, project manage, build relationships with others and write grant applications concisely. What do you enjoy about your job? Foraminifera are beautiful and each time I have microscope work to do it is a joy to see them. I enjoy being able to talk with young people about what I do. It's really rewarding to inspire the generation to go into STEM and sometimes even helps me figure out what my data mean! I like how no two days are the same. Sometimes I'm doing labwork, sometimes I am writing and sometimes I am reading about all the new and exciting science that is going on in the field. Whilst the dynamic-ness of being a researcher can sometimes be challenging in terms of work/life balance, my lab group are really supportive and I'm so lucky to be working with them. What opportunities do you have to develop your skills in your job? In my postdoc and PhD, I went to summer schools and workshops focused around Earth and ocean sciences in some really cool places, including Israel and Italy. I also went to international conferences to present my data, and regularly did outreach presentations to young people. I also had the opportunity to attend workshops focused around science policy and diversity and inclusion in the geosciences. It's definitely important to go to a variety of professional development courses, because if researchers decide academia is not for them at any point in their career, they have evidence that they have some training for other sectors. What advice or extra information do you wish you'd had before starting this career? Writing is a big part of being an academic, and it can be really challenging. But the first draft of anything will never be perfect, and words down on paper is much better than no words at all! No two days are the same when you are a geoscientist. Even if you don't pass an exam early on during undergrad, this doesn't define who you are. There are always more opportunities to do better next time. When you say you're a geologist, sometimes people will be surprised by this. But it's not weird to like rocks and fossils. Geologists and ocean scientists study some of the oldest things on the Earth, go to some absolutely amazing places (for work!), and unravel the stories of the world around them.
Jun 07, 2025
Full time
Postdoctoral Researcher (Foraminifera Geochemist) Postdoc Researcher Scroll down to read more: Rehemat Job title: Postdoctoral Researcher - Foraminifera Geochemist What does a Foraminifera Geochemist do? I am a hybrid micropalaeontologist and geochemist. A micropalaeontologist studies microscopic fossils, and a geochemist analyses the chemistry of geological materials. I use the chemistry of fossil species of foraminifera, a type of plankton with a calcium carbonate skeleton, to understand more about their ecologies and climate millions of years ago (palaeoclimatology). Different chemical elements can help me understand how hot the oceans were, whether some species of plankton lived closer to the surface of the ocean or further down in the water column, and even how much ice there was on land! I wash sediment samples, identify the plankton hiding inside, then analyse them for their chemistry and try to understand the data they produce. What formal qualifications and previous work experience did you need to get your job? When I was a teenager I did some work experience at the Natural History Museum, London and The Royal Geographical Society. Having had a super positive introduction to Earth Sciences through these experiences, I decided to do an undergraduate MSci degree in Geoscience at Royal Holloway (University of London). During my undergraduate degree I did several internships. I interned at a structural geology company, biostratigraphy company and a summer research internship focused around foraminifera and palaeoclimatology working with a PhD student in Kiel, Germany. I also volunteered at the Natural History Museum throughout the final years of my undergraduate degree. These last two experiences made me realise I could combine my love of geochemistry and ocean sciences, and I subsequently decided to do a PhD at University College London. What other skills or characteristics do you need in your job? Always be curious Always be persistent Understand how to communicate your science to non-specialists in an enthusiastic way Have good attention to detail for taxonomy Know the importance of collaboration and networking. You never know when your mass spectrometer will break and you will need to contact another lab to use their instrument! What sort of organisation do you work for? Where else could you work as a Foraminifera Geochemist? I work at a university, but those with my background can also work in many different sectors, including the oil industry (as a biostratigrapher, using foraminfera to date rock formations), analytical instrument companies, science policy and publishers. Science communication is also popular, but this is definitely applicable as a career path across geological facets! Working in the third sector (i.e. with charities and NGOs) within Trusts and Foundations/Major Donor Fundraising is also possible, because all researchers have the ability to network, collaborate, project manage, build relationships with others and write grant applications concisely. What do you enjoy about your job? Foraminifera are beautiful and each time I have microscope work to do it is a joy to see them. I enjoy being able to talk with young people about what I do. It's really rewarding to inspire the generation to go into STEM and sometimes even helps me figure out what my data mean! I like how no two days are the same. Sometimes I'm doing labwork, sometimes I am writing and sometimes I am reading about all the new and exciting science that is going on in the field. Whilst the dynamic-ness of being a researcher can sometimes be challenging in terms of work/life balance, my lab group are really supportive and I'm so lucky to be working with them. What opportunities do you have to develop your skills in your job? In my postdoc and PhD, I went to summer schools and workshops focused around Earth and ocean sciences in some really cool places, including Israel and Italy. I also went to international conferences to present my data, and regularly did outreach presentations to young people. I also had the opportunity to attend workshops focused around science policy and diversity and inclusion in the geosciences. It's definitely important to go to a variety of professional development courses, because if researchers decide academia is not for them at any point in their career, they have evidence that they have some training for other sectors. What advice or extra information do you wish you'd had before starting this career? Writing is a big part of being an academic, and it can be really challenging. But the first draft of anything will never be perfect, and words down on paper is much better than no words at all! No two days are the same when you are a geoscientist. Even if you don't pass an exam early on during undergrad, this doesn't define who you are. There are always more opportunities to do better next time. When you say you're a geologist, sometimes people will be surprised by this. But it's not weird to like rocks and fossils. Geologists and ocean scientists study some of the oldest things on the Earth, go to some absolutely amazing places (for work!), and unravel the stories of the world around them.
NHS Blood And Transplant
Cambridge, Cambridgeshire
Job Summary We have an exciting opening for a postgraduate/postdoctoral scientist, preferably in the field of immunology, to join our team. You will be part of a large transformational project in partnership with industry to develop new plasma and platelet components that can be transfused to any patient. As the technical work package lead you will be required to conduct research and coordinate controlled investigations of blood component quality. You will be required to initiate, plan, and direct such investigations - supervising the analysis and interpretation of results, and ensuring their accurate and timely dissemination in journals and reports. You will be responsible for the line management of staff working with and to the translational research programme lead. The NHS Blood and Transplant Component Development Laboratory is an internationally recognised laboratory based at Cambridge, alongside Addenbrooke's Hospital on the world-renowned Cambridge Biomedical Campus. The component development laboratory performs a wide range of research and development projects to improve the quality and safety of blood components for transfusion. Main duties of the job The role is to lead a technical work package within the Universal Components project team to develop novel plasma and platelet components that can be translated to any patient. The project team is a collaboration between NHSBT and an industrial partner. You will be responsible for delivering the technical work package working with and to the Translational Research Programme Lead. You will coordinate all the technical activities and collaborate with an industrial partner and other NHSBT researchers. You will evaluate prototypes for antibody removal and blood component quality as well as other research activities. You will disseminate research findings both inside and outside the organisation, attending project meetings as necessary. You will be responsible for training less experienced staff, students, trainees and researchers. You will be responsible for the line management of staff, working with and to the Translational Research Programme Lead. About You Experience and Knowledge High level of expertise in relevant specialism, ideally demonstrated by publications. High level of proficiency in relevant specialised laboratory techniques/ environments. In depth understanding of NHS and wider healthcare research community. To have successfully led and completed a major laboratory-based project. Experience of working with Information Technology using Microsoft Office packages (Word, Excel and PowerPoint). In depth knowledge of Haematology/Transfusion Science. Extensive experience in working in a research laboratory. Supervisory experience. Qualifications and Training Postgraduate degree or relevant professional qualification with significant practical laboratory experience. Demonstrates commitment to own continued professional development (CPD). About Us It takes all types of people to deliver the kind of service that saves and improves lives. At NHS Blood and Transplant, you'll join a team of more than 6,000 people who are making a genuine difference to communities, families, friends, relatives and more across the UK. We play a unique and special role in the NHS by helping people do something extraordinary- donate blood, blood products, organs, tissues, or stem cells to save someone in need. Our three core values are what set us apart. They guide and inspire everything we do. By being caring, expertly meeting the needs of our patients and our people, and accepting nothing less than the best quality, we can do extraordinary work - and help our people to do something extraordinary in their career, too. Three small words, one big difference - Caring, Expert and Quality. Together we'll save and improve more lives than ever. You will join us on our journey to create an inclusive workplace and aim to reflect the diverse communities we work with, and we positively encourage applications from all sectors of the community. What we offer: A starting salary of £53,755 - £60,504 per annum in accordance with Agenda for Change (AfC). A full time, fixed-term opportunity to join as a Band 8a. Opportunity to work with a national organisation and be based in our Cambridge Centre. NHSBT promotes flexible working opportunities where the role will allow. 27 days annual leave (pro rata for part-time) plus Bank Holidays, increasing to 29 days after 5 years' service and to 33 days after 10 years. NHS pension scheme. The NHS Pension Scheme is a defined benefit scheme (not dependent on investment returns) Further details and outline of benefits can be found at: We've fostered a culture of continuous learning where colleagues are well-led, engaged, and encouraged to grow. We support you in reaching your full potential, both in your current role and future career. Our Thrive program embodies our commitment to learning and development, offering a wide range of activities to support your personal and professional growth. It's open to everyone at NHSBT, ensuring you have the resources to succeed and shine in your role. Please view the attached recruitment profile which is a summary of the detailed Job Description and Person Specification for the full personal attributes we require for the role. You will need to demonstrate these throughout the recruitment process. This vacancy will close at 23:59 on Monday 26th May 2025. Interviews are anticipated to be held on Thursday 12th June - subject to confirmation. For informal enquiries please contact - Name: Melanie Munroe Job Title: Translational Research Programme Lead Contact Details:
Jun 07, 2025
Full time
Job Summary We have an exciting opening for a postgraduate/postdoctoral scientist, preferably in the field of immunology, to join our team. You will be part of a large transformational project in partnership with industry to develop new plasma and platelet components that can be transfused to any patient. As the technical work package lead you will be required to conduct research and coordinate controlled investigations of blood component quality. You will be required to initiate, plan, and direct such investigations - supervising the analysis and interpretation of results, and ensuring their accurate and timely dissemination in journals and reports. You will be responsible for the line management of staff working with and to the translational research programme lead. The NHS Blood and Transplant Component Development Laboratory is an internationally recognised laboratory based at Cambridge, alongside Addenbrooke's Hospital on the world-renowned Cambridge Biomedical Campus. The component development laboratory performs a wide range of research and development projects to improve the quality and safety of blood components for transfusion. Main duties of the job The role is to lead a technical work package within the Universal Components project team to develop novel plasma and platelet components that can be translated to any patient. The project team is a collaboration between NHSBT and an industrial partner. You will be responsible for delivering the technical work package working with and to the Translational Research Programme Lead. You will coordinate all the technical activities and collaborate with an industrial partner and other NHSBT researchers. You will evaluate prototypes for antibody removal and blood component quality as well as other research activities. You will disseminate research findings both inside and outside the organisation, attending project meetings as necessary. You will be responsible for training less experienced staff, students, trainees and researchers. You will be responsible for the line management of staff, working with and to the Translational Research Programme Lead. About You Experience and Knowledge High level of expertise in relevant specialism, ideally demonstrated by publications. High level of proficiency in relevant specialised laboratory techniques/ environments. In depth understanding of NHS and wider healthcare research community. To have successfully led and completed a major laboratory-based project. Experience of working with Information Technology using Microsoft Office packages (Word, Excel and PowerPoint). In depth knowledge of Haematology/Transfusion Science. Extensive experience in working in a research laboratory. Supervisory experience. Qualifications and Training Postgraduate degree or relevant professional qualification with significant practical laboratory experience. Demonstrates commitment to own continued professional development (CPD). About Us It takes all types of people to deliver the kind of service that saves and improves lives. At NHS Blood and Transplant, you'll join a team of more than 6,000 people who are making a genuine difference to communities, families, friends, relatives and more across the UK. We play a unique and special role in the NHS by helping people do something extraordinary- donate blood, blood products, organs, tissues, or stem cells to save someone in need. Our three core values are what set us apart. They guide and inspire everything we do. By being caring, expertly meeting the needs of our patients and our people, and accepting nothing less than the best quality, we can do extraordinary work - and help our people to do something extraordinary in their career, too. Three small words, one big difference - Caring, Expert and Quality. Together we'll save and improve more lives than ever. You will join us on our journey to create an inclusive workplace and aim to reflect the diverse communities we work with, and we positively encourage applications from all sectors of the community. What we offer: A starting salary of £53,755 - £60,504 per annum in accordance with Agenda for Change (AfC). A full time, fixed-term opportunity to join as a Band 8a. Opportunity to work with a national organisation and be based in our Cambridge Centre. NHSBT promotes flexible working opportunities where the role will allow. 27 days annual leave (pro rata for part-time) plus Bank Holidays, increasing to 29 days after 5 years' service and to 33 days after 10 years. NHS pension scheme. The NHS Pension Scheme is a defined benefit scheme (not dependent on investment returns) Further details and outline of benefits can be found at: We've fostered a culture of continuous learning where colleagues are well-led, engaged, and encouraged to grow. We support you in reaching your full potential, both in your current role and future career. Our Thrive program embodies our commitment to learning and development, offering a wide range of activities to support your personal and professional growth. It's open to everyone at NHSBT, ensuring you have the resources to succeed and shine in your role. Please view the attached recruitment profile which is a summary of the detailed Job Description and Person Specification for the full personal attributes we require for the role. You will need to demonstrate these throughout the recruitment process. This vacancy will close at 23:59 on Monday 26th May 2025. Interviews are anticipated to be held on Thursday 12th June - subject to confirmation. For informal enquiries please contact - Name: Melanie Munroe Job Title: Translational Research Programme Lead Contact Details:
Job ID: Amazon Development Centre (London) Limited Amazon is looking for talented Postdoctoral Scientists to join our team for a one-year, full-time research position. Postdoctoral Scientists will innovate in key areas of machine learning, natural language processing, computer vision, automated reasoning, robotics, or quantum technologies. As part of the Rufus Features Science team in London, the postdoc will work on shaping the future of AI-driven shopping experiences at Amazon. In particular, the project focuses on conversational search in shopping, developing next-generation conversational search systems in the shopping domain that seamlessly bridge natural shopping dialogues with precise product retrieval and recommendation. Key challenges include developing new methods for grounding conversational context in product attribute space, designing efficient retrieval mechanisms that can handle both structured product metadata and unstructured conversational context, and creating evaluation frameworks that capture both conversation quality and search relevance. The project will extend beyond traditional conversational search paradigms by integrating agentic frameworks that can proactively identify, clarify, and refine user needs through strategic dialogue management, while simultaneously orchestrating multiple specialized retrieval agents for different aspects of the shopping journey (e.g., attribute extraction, price comparison, review analysis, and specification matching). We experiment and innovate relentlessly. Science is core in our offering to shoppers, advertisers and customers. Our scientists apply machine learning, optimization, causal modeling and game theory at scale to enhance the customer experience, help advertisers reach relevant audiences, and support brand building. We are seeking talented scientists to invent cutting-edge techniques in a variety of areas and innovate on behalf of shoppers, advertisers, and customers. In this role you will: Lead research projects in conversational search and retrieval-augmented systems Develop novel architectures combining dialogue management with product search Design and implement evaluation frameworks for agentic conversational shopping systems Publish research findings in top-tier conferences and journals Mentor junior researchers and contribute to the team's scientific direction BASIC QUALIFICATIONS PhD in Computer Science, Machine Learning, Information Retrieval or related field Strong publication record in NLP, Information Retrieval, or Conversational AI Experience with large language models and retrieval-augmented generation Research background in conversational systems or dialogue management Experience with modern deep learning frameworks (PyTorch, TensorFlow) Excellent written and verbal communication skills PREFERRED QUALIFICATIONS Knowledge of multi-agent systems and tool-use frameworks Experience with e-commerce or shopping domain applications Publications at top venues (ACL, NeurIPS, SIGIR, AAAI, etc.) Amazon is an equal opportunities employer. We believe passionately that employing a diverse workforce is central to our success. We make recruiting decisions based on your experience and skills. We value your passion to discover, invent, simplify and build. Protecting your privacy and the security of your data is a longstanding top priority for Amazon. Please consult our Privacy Notice ( ) to know more about how we collect, use and transfer the personal data of our candidates. Amazon is an equal opportunity employer and does not discriminate on the basis of protected veteran status, disability, or other legally protected status. Our inclusive culture empowers Amazonians to deliver the best results for our customers. If you have a disability and need a workplace accommodation or adjustment during the application and hiring process, including support for the interview or onboarding process, please visit for more information. If the country/region you're applying in isn't listed, please contact your Recruiting Partner. Posted: May 16, 2025 (Updated 2 days ago) Posted: May 19, 2025 (Updated 4 days ago) Posted: April 16, 2025 (Updated 8 days ago) Posted: April 11, 2025 (Updated 8 days ago) Amazon is an equal opportunity employer and does not discriminate on the basis of protected veteran status, disability, or other legally protected status.
Jun 07, 2025
Full time
Job ID: Amazon Development Centre (London) Limited Amazon is looking for talented Postdoctoral Scientists to join our team for a one-year, full-time research position. Postdoctoral Scientists will innovate in key areas of machine learning, natural language processing, computer vision, automated reasoning, robotics, or quantum technologies. As part of the Rufus Features Science team in London, the postdoc will work on shaping the future of AI-driven shopping experiences at Amazon. In particular, the project focuses on conversational search in shopping, developing next-generation conversational search systems in the shopping domain that seamlessly bridge natural shopping dialogues with precise product retrieval and recommendation. Key challenges include developing new methods for grounding conversational context in product attribute space, designing efficient retrieval mechanisms that can handle both structured product metadata and unstructured conversational context, and creating evaluation frameworks that capture both conversation quality and search relevance. The project will extend beyond traditional conversational search paradigms by integrating agentic frameworks that can proactively identify, clarify, and refine user needs through strategic dialogue management, while simultaneously orchestrating multiple specialized retrieval agents for different aspects of the shopping journey (e.g., attribute extraction, price comparison, review analysis, and specification matching). We experiment and innovate relentlessly. Science is core in our offering to shoppers, advertisers and customers. Our scientists apply machine learning, optimization, causal modeling and game theory at scale to enhance the customer experience, help advertisers reach relevant audiences, and support brand building. We are seeking talented scientists to invent cutting-edge techniques in a variety of areas and innovate on behalf of shoppers, advertisers, and customers. In this role you will: Lead research projects in conversational search and retrieval-augmented systems Develop novel architectures combining dialogue management with product search Design and implement evaluation frameworks for agentic conversational shopping systems Publish research findings in top-tier conferences and journals Mentor junior researchers and contribute to the team's scientific direction BASIC QUALIFICATIONS PhD in Computer Science, Machine Learning, Information Retrieval or related field Strong publication record in NLP, Information Retrieval, or Conversational AI Experience with large language models and retrieval-augmented generation Research background in conversational systems or dialogue management Experience with modern deep learning frameworks (PyTorch, TensorFlow) Excellent written and verbal communication skills PREFERRED QUALIFICATIONS Knowledge of multi-agent systems and tool-use frameworks Experience with e-commerce or shopping domain applications Publications at top venues (ACL, NeurIPS, SIGIR, AAAI, etc.) Amazon is an equal opportunities employer. We believe passionately that employing a diverse workforce is central to our success. We make recruiting decisions based on your experience and skills. We value your passion to discover, invent, simplify and build. Protecting your privacy and the security of your data is a longstanding top priority for Amazon. Please consult our Privacy Notice ( ) to know more about how we collect, use and transfer the personal data of our candidates. Amazon is an equal opportunity employer and does not discriminate on the basis of protected veteran status, disability, or other legally protected status. Our inclusive culture empowers Amazonians to deliver the best results for our customers. If you have a disability and need a workplace accommodation or adjustment during the application and hiring process, including support for the interview or onboarding process, please visit for more information. If the country/region you're applying in isn't listed, please contact your Recruiting Partner. Posted: May 16, 2025 (Updated 2 days ago) Posted: May 19, 2025 (Updated 4 days ago) Posted: April 16, 2025 (Updated 8 days ago) Posted: April 11, 2025 (Updated 8 days ago) Amazon is an equal opportunity employer and does not discriminate on the basis of protected veteran status, disability, or other legally protected status.
Senior Laboratory Research Scientist (SLRS) - Crystallography/Drug Discovery About us The Francis Crick Institute is Europe's largest biomedical research institute under one roof. Our world-class scientists and staff collaborate on vital research to help prevent, diagnose and treat illnesses such as cancer, heart disease, infectious diseases and neurodegenerative conditions. The Crick is a place for collaboration, innovation and exploration across many disciplines. A space where the brightest minds can pursue big and bold ideas and discover answers to crucial scientific questions. We support them in a dynamic environment which fosters excellence with state-of-the-art infrastructure, cutting-edge facilities, and a creative and curious culture. We've removed traditional boundaries of departments, divisions and disciplines and instead have an open approach that supports every researcher. This gives us the freedom to take risks and carry out high-quality, pioneering research. Creating a space for discovery without boundaries helps us to turn our science into benefits for human health and the economy. About the role This exciting research project is a cross-Francis Crick Institute collaboration focusing on the translation of cutting-edge research led by Dr. Simon Boulton in the Double Strand Break (DSB) Metabolism Laboratory. Researchers in this lab have identified cellular processes contributing to the alternative lengthening of telomeres (ALT) mechanism in certain cancers. This collaboration aims to translate these insights into therapies for ALT-positive cancers. The position offers experience in drug discovery interfaced with disease biology, guided by experts in pharmaceutical research and DNA Damage Repair. This work is funded through a 3-year £3M programme supported by the philanthropic Chris Banton fund and LifeArc. The project involves a team of scientists across several laboratories and technology platforms at the Crick. What you will be doing We seek a creative, motivated structural biologist with a strong background in crystallography and drug discovery to support early-stage drug probe development on the ALT project. You will work within the Structural Biology Science Technology Platform (SB STP), which covers protein expression, purification, biophysics, X-ray crystallography, and cryo-EM. You will be responsible for all aspects of protein structure determination, including sample prep, data collection, processing, structure determination, and data presentation. You are expected to contribute to ongoing projects and process improvements. As a Senior Laboratory Research Scientist at the Crick, you will: Develop robust purification protocols for high-quality recombinant proteins for structural studies. Determine crystal structures of target proteins with bound fragments/compounds. Train and supervise junior team members or students. Maintain up-to-date knowledge of relevant literature, communicate key developments, and implement new techniques. About you You will bring: PhD in structural biology with postdoctoral or equivalent experience. Extensive experience in molecular cloning, recombinant protein expression, and purification using ÄKTA systems and chromatographic techniques. Expertise in biophysical quality control methods for crystallography-grade proteins. Experience in X-ray crystallography, including crystallization, data collection, structure determination, and refinement, using robots like Mosquito and NT8. Proficiency with crystallographic software such as CCP4, CCP4cloud, Phenix, and Coot. Deep knowledge of high-throughput crystallography techniques.
Jun 07, 2025
Full time
Senior Laboratory Research Scientist (SLRS) - Crystallography/Drug Discovery About us The Francis Crick Institute is Europe's largest biomedical research institute under one roof. Our world-class scientists and staff collaborate on vital research to help prevent, diagnose and treat illnesses such as cancer, heart disease, infectious diseases and neurodegenerative conditions. The Crick is a place for collaboration, innovation and exploration across many disciplines. A space where the brightest minds can pursue big and bold ideas and discover answers to crucial scientific questions. We support them in a dynamic environment which fosters excellence with state-of-the-art infrastructure, cutting-edge facilities, and a creative and curious culture. We've removed traditional boundaries of departments, divisions and disciplines and instead have an open approach that supports every researcher. This gives us the freedom to take risks and carry out high-quality, pioneering research. Creating a space for discovery without boundaries helps us to turn our science into benefits for human health and the economy. About the role This exciting research project is a cross-Francis Crick Institute collaboration focusing on the translation of cutting-edge research led by Dr. Simon Boulton in the Double Strand Break (DSB) Metabolism Laboratory. Researchers in this lab have identified cellular processes contributing to the alternative lengthening of telomeres (ALT) mechanism in certain cancers. This collaboration aims to translate these insights into therapies for ALT-positive cancers. The position offers experience in drug discovery interfaced with disease biology, guided by experts in pharmaceutical research and DNA Damage Repair. This work is funded through a 3-year £3M programme supported by the philanthropic Chris Banton fund and LifeArc. The project involves a team of scientists across several laboratories and technology platforms at the Crick. What you will be doing We seek a creative, motivated structural biologist with a strong background in crystallography and drug discovery to support early-stage drug probe development on the ALT project. You will work within the Structural Biology Science Technology Platform (SB STP), which covers protein expression, purification, biophysics, X-ray crystallography, and cryo-EM. You will be responsible for all aspects of protein structure determination, including sample prep, data collection, processing, structure determination, and data presentation. You are expected to contribute to ongoing projects and process improvements. As a Senior Laboratory Research Scientist at the Crick, you will: Develop robust purification protocols for high-quality recombinant proteins for structural studies. Determine crystal structures of target proteins with bound fragments/compounds. Train and supervise junior team members or students. Maintain up-to-date knowledge of relevant literature, communicate key developments, and implement new techniques. About you You will bring: PhD in structural biology with postdoctoral or equivalent experience. Extensive experience in molecular cloning, recombinant protein expression, and purification using ÄKTA systems and chromatographic techniques. Expertise in biophysical quality control methods for crystallography-grade proteins. Experience in X-ray crystallography, including crystallization, data collection, structure determination, and refinement, using robots like Mosquito and NT8. Proficiency with crystallographic software such as CCP4, CCP4cloud, Phenix, and Coot. Deep knowledge of high-throughput crystallography techniques.
Four Squared Recruitment Ltd
Cambridge, Cambridgeshire
Environmental Risk Modeller Location: Cambridge, Cambridgeshire (Hybrid) Salary: 60-85k Job Type: Full-time, Permanent About the Role We are seeking a quantitative modeller to support the development of climate physical risk and nature modelling efforts for an innovative and fast-growing organisation. The successful candidate will be responsible for quantifying the impacts and dependencies of businesses on climate and nature, working alongside a talented team of modellers, economists, data scientists, and software engineers. This is an exciting opportunity for an ambitious individual looking to work on cutting-edge analytics with some of the world s largest and most forward-thinking corporations. Key Responsibilities Develop models using novel techniques to assess risks from climate change and nature, translating complex scientific concepts into quantified financial impacts for businesses. Write Python code to integrate models into the company s analytics platform. Build and analyse geospatial data layers to support risk modelling. Deliver actionable insights and analytics relevant to corporate decision-making. Act as a subject matter expert on nature and climate-related risks and opportunities. Collaborate with internal teams and clients, requiring a minimum of three days per week in the Cambridge office. Essential Skills & Experience A Bachelor s degree in natural sciences, physics, engineering, or a related field. Experience delivering environmental or sustainability-related projects to corporate clients. Strong knowledge of mathematical modelling, including statistics, geospatial analysis, and probability, with practical applications to real-world problems. Proficiency in Python (preferred), R, or MATLAB for scientific programming. Experience working with large geospatial and environmental datasets (e.g., CMIP6, SSPs, or nature data layers). Strong research skills with the ability to translate data into actionable models and insights. Excellent communication skills, with the ability to present complex scientific concepts to non-technical audiences. Ability to work effectively in a fast-paced environment, managing multiple projects while collaborating with a diverse team of scientists and engineers. Desirable Skills Postdoctoral research experience in a relevant field. Experience in model development (e.g., natural catastrophe modelling, risk quantification). Cross-disciplinary expertise in areas such as natural sciences, agronomy, or environmental economics. Experience quantifying the economic impact of climate and nature-related risks to inform business or government decision-making. Why Join? Be part of a rapidly growing organisation at the forefront of climate and environmental risk modelling. Work on high-impact projects with leading global corporations. Collaborate with a highly skilled team of scientists, engineers, and industry experts. Competitive salary and opportunities for career progression.
Feb 21, 2025
Full time
Environmental Risk Modeller Location: Cambridge, Cambridgeshire (Hybrid) Salary: 60-85k Job Type: Full-time, Permanent About the Role We are seeking a quantitative modeller to support the development of climate physical risk and nature modelling efforts for an innovative and fast-growing organisation. The successful candidate will be responsible for quantifying the impacts and dependencies of businesses on climate and nature, working alongside a talented team of modellers, economists, data scientists, and software engineers. This is an exciting opportunity for an ambitious individual looking to work on cutting-edge analytics with some of the world s largest and most forward-thinking corporations. Key Responsibilities Develop models using novel techniques to assess risks from climate change and nature, translating complex scientific concepts into quantified financial impacts for businesses. Write Python code to integrate models into the company s analytics platform. Build and analyse geospatial data layers to support risk modelling. Deliver actionable insights and analytics relevant to corporate decision-making. Act as a subject matter expert on nature and climate-related risks and opportunities. Collaborate with internal teams and clients, requiring a minimum of three days per week in the Cambridge office. Essential Skills & Experience A Bachelor s degree in natural sciences, physics, engineering, or a related field. Experience delivering environmental or sustainability-related projects to corporate clients. Strong knowledge of mathematical modelling, including statistics, geospatial analysis, and probability, with practical applications to real-world problems. Proficiency in Python (preferred), R, or MATLAB for scientific programming. Experience working with large geospatial and environmental datasets (e.g., CMIP6, SSPs, or nature data layers). Strong research skills with the ability to translate data into actionable models and insights. Excellent communication skills, with the ability to present complex scientific concepts to non-technical audiences. Ability to work effectively in a fast-paced environment, managing multiple projects while collaborating with a diverse team of scientists and engineers. Desirable Skills Postdoctoral research experience in a relevant field. Experience in model development (e.g., natural catastrophe modelling, risk quantification). Cross-disciplinary expertise in areas such as natural sciences, agronomy, or environmental economics. Experience quantifying the economic impact of climate and nature-related risks to inform business or government decision-making. Why Join? Be part of a rapidly growing organisation at the forefront of climate and environmental risk modelling. Work on high-impact projects with leading global corporations. Collaborate with a highly skilled team of scientists, engineers, and industry experts. Competitive salary and opportunities for career progression.
National Nuclear Laboratory Limited
Seascale, Cumbria
Job Description This is where your skills play a critical role in keeping everyone safe.Working in Safety, Security & Safeguards gives you the chance to make your mark on some hugely interesting projects.UKNNL does work that nobody else in the sector is doing, and this means we need experts like you to make it possible, whilst keeping everyone safe. Were committed to using nuclear science to benefit society for years to come.This means that you can build a long and successful career here whilst playing a meaningful role in delivering cleaner energy, reducing waste and keeping colleagues and the public out of harms way. As the national laboratory for nuclear fission in the UK, we are harnessing nuclear science to solve some of the worlds biggest challenges. The Measurement and Analysis, instrumentation and in-situ analysis team (M&A-IIA) are involved in development of new technologies for radiometric applications and deployment challenges. The team are looking for an individual to join this growing team to play an important part in allowing NNL to fulfil future commitments and develop into a subject matter expert for future programmes of work and become a technical lead. To join the UKNNL Post Doctorate programme you will have a PhD in radiometric physics, nuclear instrumentation or similar and able to work with engineering, sensor and instrument suppliers. You will have the right to work in the UK and be able to achieve SC level security clearance (this includes but is not limited to identity, employment, financial and criminal record checks plus 5 years worth of UK residency). Main Responsibilities We are developing the next generation of technical experts.Not only will you receive the opportunity to work on challenging and exciting projects, but youll continually learn from skilled and knowledgeable industry experts who are leaders in their field.We will help you become everything you can be, by challenging, stretching, and pushing you to your limits while supporting you every step of the way. You will have the opportunity to work on innovation projects for radiometric instrumentation and customer work for the future, develop your knowledge of radiometric detectors and experience in radiometric systems, and help the Measurement and Analysis, instrumentation and in-situ analysis team deliver decommissioning for the Sellafield site. You will support research and other customer work, experimental design, provide experimental data, data analysis, testing and underpinning evidence for instrumentation and processes. UKNNL recognises that academia and industry are very different environments, our Postdoctoral Development Scheme will smooth the transition whilst supporting you as you take your first steps towards becoming a Subject Matter Expert. Your two-year scheme will provide the opportunity to develop your technical knowledge and skills whilst providing you with an insight into UKNNLs strategy and direction. You will receive an overview of how the company operates and delivers its projects. You will undertake personal development through training aligned to your personal development plan and understand your strengths, weaknesses, and behaviours. You will receive a personal budget to support your development within your field of expertise. From day one youll have a role in a technical team involved in delivering real customer projects.You will have direct sight of the value that your skills and knowledge have to our industry and by extension our society.The Postdoctoral Development Scheme runs alongside your role, providing you the space and skills to develop in a commercial environment whilst helping you decide how to advance your technical expertise. Our two-year programme is designed to give you: An introduction to UKNNL so you understand where we sit in the wider context of the nuclear industry and how we work An introduction to the technical expertise at the core of our business so you understand how your expertise interrelates with our wider technical portfolio A clear pathway of technical development Commercial awareness of the Business Operations of UKNNL Opportunity to network with mid-career professionals and experts Mentoring to achieve chartered status with your chosen professional body A choice of development activities tailored to you and your career aspirations Membership of a cohort of early career professionals to provide support in developing within the company The support of a dedicated early careers team and our strong, thriving early careers community. You will be based at our Central Laboratory, the most modern and advanced facility of its kind in the world. On the doorstep of the Lake District National Park,our Sellafield site offer you the opportunity to work with incredible people on extraordinary projects whilst enjoying some of the most unique and beautiful landscapes the UK has to offer, providing an excellent quality of life. This role allows for hybrid working with the flexibility to work from home on some of your working days. As part of the selection process for the Post Doctorate programme you will complete a Technical Interview against the skills and competencies required for this role. Why join us? UKNNL isnt just a place where you can do career-defining work that makes a real-world impact. Its also a place where youll feel appreciated and valued. Were creating an inclusive workplace where everyone is free to be themselves and feel like they belong.We put your wellbeing first, we push you to reach your potential, and we do everything possible to help you feel safe, supported and inspired. We also offer a range of employee benefits: Sector leading Family-Focused Policies: celebrate life events, including enhanced maternity and paternity leave and a week off for your marriage. UKNNL offers attractive pension plans. If you contribute 5%, UKNNL contributes 15%. Alternatively, if you choose not to contribute (0%), UKNNL will still contribute 10%. Annual Leave: Benefit from 25.5 days of leave, plus 4 extra days to be taken during Christmas shutdown, plus Bank Holidays. Reduced gym membership with discounts of up to 25% from 3,700 gym and leisure providers across the UK Company Bonus: Be rewarded for your contributions. Learning Opportunities: Enhance your skills through excellent development programmes. Employee Assistance: Access support for personal and professional challenges. Cycle to Work: Stay active and eco-friendly. Life Assurance: Ensure peace of mind for you and your loved ones. Enhanced Sick Pay Benefits: Receive support during illness or injury. Access to Mydiscounts which has a range of special offers and discounts from more than 200 suppliers, including medical insurance and dental insurance. Health Care: Health savings plan which allows you to claim money back on visits to the dentist, optician and/or physiotherapist (limits apply). About The Company UKNNL is an incredible place to work. A place where people do things that have never been done before. A place where people push boundaries to further themselves, the business and society as a whole. This is a place where personal and professional opportunities are limitless.If you want to change the world, if you want to tackle climate change, if you want to help advance medical science, if you want to help put things in space, if you want to answer the big questions, if you want to work with extraordinary materials, if you want to meet great people, learn new skills, challenge yourself, work flexibly, and build a long successful career with the power to make a real impact you can do it all here. Equality, Diversity and Inclusion UKNNL has a vision for Equality, Diversity and Inclusivity (ED&I) where UKNNL aims to be an inclusive workplace that attracts diverse talent through transparent and equal policies and procedures, providing reasonable adjustments as appropriate.We want you and the diverse mix of people that we employ, customers that we service and stakeholders that we influence to feel valued.We encourage a workplace culture where everyone can thrive with a sense of belonging and the ability to access to workplace in a way which works for you. Recruitment Agency Notice We operate a strict Preferred Supplier List (PSL) for the provision of recruitment services. Only agencies on our PSL may provide CVs and only when the role is released to them by our recruitment team. We will not accept unsolicited CVs from suppliers not currently on our PSL. We explicitly reserve the right to add candidate details from unsolicited CVs from non-PSL agencies into our own candidate database and to pursue/hire such candidate(s) without any obligation, financial or otherwise, to the agency concerned. JBRP1_UKTJ
Feb 20, 2025
Full time
Job Description This is where your skills play a critical role in keeping everyone safe.Working in Safety, Security & Safeguards gives you the chance to make your mark on some hugely interesting projects.UKNNL does work that nobody else in the sector is doing, and this means we need experts like you to make it possible, whilst keeping everyone safe. Were committed to using nuclear science to benefit society for years to come.This means that you can build a long and successful career here whilst playing a meaningful role in delivering cleaner energy, reducing waste and keeping colleagues and the public out of harms way. As the national laboratory for nuclear fission in the UK, we are harnessing nuclear science to solve some of the worlds biggest challenges. The Measurement and Analysis, instrumentation and in-situ analysis team (M&A-IIA) are involved in development of new technologies for radiometric applications and deployment challenges. The team are looking for an individual to join this growing team to play an important part in allowing NNL to fulfil future commitments and develop into a subject matter expert for future programmes of work and become a technical lead. To join the UKNNL Post Doctorate programme you will have a PhD in radiometric physics, nuclear instrumentation or similar and able to work with engineering, sensor and instrument suppliers. You will have the right to work in the UK and be able to achieve SC level security clearance (this includes but is not limited to identity, employment, financial and criminal record checks plus 5 years worth of UK residency). Main Responsibilities We are developing the next generation of technical experts.Not only will you receive the opportunity to work on challenging and exciting projects, but youll continually learn from skilled and knowledgeable industry experts who are leaders in their field.We will help you become everything you can be, by challenging, stretching, and pushing you to your limits while supporting you every step of the way. You will have the opportunity to work on innovation projects for radiometric instrumentation and customer work for the future, develop your knowledge of radiometric detectors and experience in radiometric systems, and help the Measurement and Analysis, instrumentation and in-situ analysis team deliver decommissioning for the Sellafield site. You will support research and other customer work, experimental design, provide experimental data, data analysis, testing and underpinning evidence for instrumentation and processes. UKNNL recognises that academia and industry are very different environments, our Postdoctoral Development Scheme will smooth the transition whilst supporting you as you take your first steps towards becoming a Subject Matter Expert. Your two-year scheme will provide the opportunity to develop your technical knowledge and skills whilst providing you with an insight into UKNNLs strategy and direction. You will receive an overview of how the company operates and delivers its projects. You will undertake personal development through training aligned to your personal development plan and understand your strengths, weaknesses, and behaviours. You will receive a personal budget to support your development within your field of expertise. From day one youll have a role in a technical team involved in delivering real customer projects.You will have direct sight of the value that your skills and knowledge have to our industry and by extension our society.The Postdoctoral Development Scheme runs alongside your role, providing you the space and skills to develop in a commercial environment whilst helping you decide how to advance your technical expertise. Our two-year programme is designed to give you: An introduction to UKNNL so you understand where we sit in the wider context of the nuclear industry and how we work An introduction to the technical expertise at the core of our business so you understand how your expertise interrelates with our wider technical portfolio A clear pathway of technical development Commercial awareness of the Business Operations of UKNNL Opportunity to network with mid-career professionals and experts Mentoring to achieve chartered status with your chosen professional body A choice of development activities tailored to you and your career aspirations Membership of a cohort of early career professionals to provide support in developing within the company The support of a dedicated early careers team and our strong, thriving early careers community. You will be based at our Central Laboratory, the most modern and advanced facility of its kind in the world. On the doorstep of the Lake District National Park,our Sellafield site offer you the opportunity to work with incredible people on extraordinary projects whilst enjoying some of the most unique and beautiful landscapes the UK has to offer, providing an excellent quality of life. This role allows for hybrid working with the flexibility to work from home on some of your working days. As part of the selection process for the Post Doctorate programme you will complete a Technical Interview against the skills and competencies required for this role. Why join us? UKNNL isnt just a place where you can do career-defining work that makes a real-world impact. Its also a place where youll feel appreciated and valued. Were creating an inclusive workplace where everyone is free to be themselves and feel like they belong.We put your wellbeing first, we push you to reach your potential, and we do everything possible to help you feel safe, supported and inspired. We also offer a range of employee benefits: Sector leading Family-Focused Policies: celebrate life events, including enhanced maternity and paternity leave and a week off for your marriage. UKNNL offers attractive pension plans. If you contribute 5%, UKNNL contributes 15%. Alternatively, if you choose not to contribute (0%), UKNNL will still contribute 10%. Annual Leave: Benefit from 25.5 days of leave, plus 4 extra days to be taken during Christmas shutdown, plus Bank Holidays. Reduced gym membership with discounts of up to 25% from 3,700 gym and leisure providers across the UK Company Bonus: Be rewarded for your contributions. Learning Opportunities: Enhance your skills through excellent development programmes. Employee Assistance: Access support for personal and professional challenges. Cycle to Work: Stay active and eco-friendly. Life Assurance: Ensure peace of mind for you and your loved ones. Enhanced Sick Pay Benefits: Receive support during illness or injury. Access to Mydiscounts which has a range of special offers and discounts from more than 200 suppliers, including medical insurance and dental insurance. Health Care: Health savings plan which allows you to claim money back on visits to the dentist, optician and/or physiotherapist (limits apply). About The Company UKNNL is an incredible place to work. A place where people do things that have never been done before. A place where people push boundaries to further themselves, the business and society as a whole. This is a place where personal and professional opportunities are limitless.If you want to change the world, if you want to tackle climate change, if you want to help advance medical science, if you want to help put things in space, if you want to answer the big questions, if you want to work with extraordinary materials, if you want to meet great people, learn new skills, challenge yourself, work flexibly, and build a long successful career with the power to make a real impact you can do it all here. Equality, Diversity and Inclusion UKNNL has a vision for Equality, Diversity and Inclusivity (ED&I) where UKNNL aims to be an inclusive workplace that attracts diverse talent through transparent and equal policies and procedures, providing reasonable adjustments as appropriate.We want you and the diverse mix of people that we employ, customers that we service and stakeholders that we influence to feel valued.We encourage a workplace culture where everyone can thrive with a sense of belonging and the ability to access to workplace in a way which works for you. Recruitment Agency Notice We operate a strict Preferred Supplier List (PSL) for the provision of recruitment services. Only agencies on our PSL may provide CVs and only when the role is released to them by our recruitment team. We will not accept unsolicited CVs from suppliers not currently on our PSL. We explicitly reserve the right to add candidate details from unsolicited CVs from non-PSL agencies into our own candidate database and to pursue/hire such candidate(s) without any obligation, financial or otherwise, to the agency concerned. JBRP1_UKTJ
Barts Cancer Institute , Queen Mary University London
About the Role Postdoctoral Research Assistant to join Dr Gallipoli's team (). We study the biological mechanisms underpinning myeloid leukaemia development, progression and therapy resistance with a strong focus on the role of metabolism (Dembitz, Leukemia 2024;Woodley, Nature Communication 2023&Gallipoli, Blood 2018). The successful applicant will investigate how microenvironmental and organismal metabolism affects leukemia cell intrinsic targetable dependencies with the aim to improve current therapeutics efficacy. Informal enquiries are highly encouraged. About You We are seeking highly-motivated researchers holding or near completion of a PhD in a relevant biological or life sciences subject. The ability to develop independent insights into the project, solve complex problems and willingness to work flexibly within a team to achieve the project demands are needed. Experience with flow cytometry, primary cell culture, molecular biology, animal work, metabolic/transcriptional profiling is highly desirable. About Institute The Barts Cancer Institute (BCI) is a Cancer Research UK Centre of Excellence whose work aims to transform the lives of those with and at risk of cancer through innovative research in the laboratory, in patients and in populations. It is one of six institutes within The Faculty of Medicine and Dentistry (FMD) BCI is internationally renowned in many areas of cancer research and it combines ground-breaking basic research with the expertise of clinicians and clinician scientists from the Centre for Experimental Cancer Medicine and the Barts NHS Trust to achieve improvements in cancer patient care. BCI is also a partner in the CRUK City of London Major Centre (together with UCL, Kings and the Francis Crick Institute) which is a Centre of Excellence in Biotherapeutics. BCI is committed in supporting and developing future cancer researchers through its extensive postgraduate training. About Queen Mary At Queen Mary University of London, we believe that a diversity of ideas helps us achieve the previously unthinkable. Throughout our history, we've fostered social justice and improved lives through academic excellence. And we continue to live and breathe this spirit today, not because it's simply 'the right thing to do' but for what it helps us achieve and the intellectual brilliance it delivers. We continue to embrace diversity of thought and opinion in everything we do, in the belief that when views collide, disciplines interact, and perspectives intersect, truly original thought takes form. Benefits We offer competitive salaries, access to a generous pension scheme, 30 days' leave per annum (pro-rata for part-time/fixed-term), a season ticket loan scheme and access to a comprehensive range of personal and professional development opportunities. In addition, we offer a range of work life balance and family friendly, inclusive employment policies, flexible working arrangements, and campus facilities. The post is based at the Centre for Haemato-Oncology, Barts Cancer Institute. It is full time, fixed term for 12 months, with an expected start date of April 2025. The starting salary will be Grade 4 (SP 26-33), in the range of £38,082 - £45,622 per annum, inclusive of London Allowance. Queen Mary's commitment to our diverse and inclusive community is embedded in our appointments processes. Reasonable adjustments will be made at each stage of the recruitment process for any candidate with a disability. We are open to considering applications from candidates wishing to work flexibly.
Feb 19, 2025
Full time
About the Role Postdoctoral Research Assistant to join Dr Gallipoli's team (). We study the biological mechanisms underpinning myeloid leukaemia development, progression and therapy resistance with a strong focus on the role of metabolism (Dembitz, Leukemia 2024;Woodley, Nature Communication 2023&Gallipoli, Blood 2018). The successful applicant will investigate how microenvironmental and organismal metabolism affects leukemia cell intrinsic targetable dependencies with the aim to improve current therapeutics efficacy. Informal enquiries are highly encouraged. About You We are seeking highly-motivated researchers holding or near completion of a PhD in a relevant biological or life sciences subject. The ability to develop independent insights into the project, solve complex problems and willingness to work flexibly within a team to achieve the project demands are needed. Experience with flow cytometry, primary cell culture, molecular biology, animal work, metabolic/transcriptional profiling is highly desirable. About Institute The Barts Cancer Institute (BCI) is a Cancer Research UK Centre of Excellence whose work aims to transform the lives of those with and at risk of cancer through innovative research in the laboratory, in patients and in populations. It is one of six institutes within The Faculty of Medicine and Dentistry (FMD) BCI is internationally renowned in many areas of cancer research and it combines ground-breaking basic research with the expertise of clinicians and clinician scientists from the Centre for Experimental Cancer Medicine and the Barts NHS Trust to achieve improvements in cancer patient care. BCI is also a partner in the CRUK City of London Major Centre (together with UCL, Kings and the Francis Crick Institute) which is a Centre of Excellence in Biotherapeutics. BCI is committed in supporting and developing future cancer researchers through its extensive postgraduate training. About Queen Mary At Queen Mary University of London, we believe that a diversity of ideas helps us achieve the previously unthinkable. Throughout our history, we've fostered social justice and improved lives through academic excellence. And we continue to live and breathe this spirit today, not because it's simply 'the right thing to do' but for what it helps us achieve and the intellectual brilliance it delivers. We continue to embrace diversity of thought and opinion in everything we do, in the belief that when views collide, disciplines interact, and perspectives intersect, truly original thought takes form. Benefits We offer competitive salaries, access to a generous pension scheme, 30 days' leave per annum (pro-rata for part-time/fixed-term), a season ticket loan scheme and access to a comprehensive range of personal and professional development opportunities. In addition, we offer a range of work life balance and family friendly, inclusive employment policies, flexible working arrangements, and campus facilities. The post is based at the Centre for Haemato-Oncology, Barts Cancer Institute. It is full time, fixed term for 12 months, with an expected start date of April 2025. The starting salary will be Grade 4 (SP 26-33), in the range of £38,082 - £45,622 per annum, inclusive of London Allowance. Queen Mary's commitment to our diverse and inclusive community is embedded in our appointments processes. Reasonable adjustments will be made at each stage of the recruitment process for any candidate with a disability. We are open to considering applications from candidates wishing to work flexibly.
The Pirbright Institute delivers world-leading research to understand, predict, detect and respond to viral disease outbreaks. We study viruses of livestock that are endemic and exotic to the UK, including zoonotic viruses, by using the most advanced tools and technologies to understand host-pathogen interactions in animals and arthropod vectors. Our major strength in understanding the immune systems of livestock provides a platform to control current diseases and respond to emerging threats. Our Institute is made up of a dynamic and vibrant community of staff covering a diverse set of chosen fields, backgrounds and experience. We all play a crucial role in furthering the Institute's aspirations, advancing the frontiers of science and knowledge through our excellent scientific research, knowledge sharing and contribution; with a real focus in improving the world in which we live. Our outlook is always balanced by our strong sense of purpose, values and behaviours and an unwavering commitment to a 'one Institute' approach. Organisation position and purpose The Pirbright Institute is seeking a highly motivated Postdoctoral Scientist to join Professor Simon Graham's research group as part of an international team tackling Nipah virus, a high-priority zoonotic pathogen. This role is funded through the UKRI-Southeast Asia Collaboration on Infectious Diseases and offers an exciting opportunity to contribute to the development of next-generation vaccines and therapeutics. About the project: Titled "DNA-launched Nipah virus vaccines and therapeutics," this project aims to leverage our innovative DNA-delivery platform to create effective, affordable, and scalable interventions against Nipah virus. Our cutting-edge polymer/peptide nano-formulation technology enables efficient DNA vector delivery, presenting a promising and deployable vaccination and treatment strategy. The project is a collaboration between The Pirbright Institute, the University of Nottingham (UK), and the University of Malaya (Malaysia) and aims to generate the crucial preclinical efficacy data needed for further clinical translation. Professor Simon Graham will serve as the UK Project Lead and direct line manager for the postholder. This is a fantastic opportunity for a postdoctoral scientist passionate about virology, immunology, and translational research to make a tangible impact in global infectious disease control. Main duties and responsibilities: Preclinical Evaluation of DNA-Vectored Therapeutics & Vaccines Conduct pharmacokinetic studies on DNA-vectored therapeutic monoclonal antibodies and assess the immunogenicity of DNA-vectored vaccines in mice and pigs. Produce and purify key research materials, including recombinant Nipah virus glycoproteins, monoclonal antibodies, and pseudo viruses. Coordinate animal studies in collaboration with project partners and contract research organizations, ensuring adherence to study protocols. Analyse antibody responses using pseudovirus neutralization assays and ELISA techniques. Assess T cell responses through IFN-γ ELISpot assays and flow cytometric analysis. Contribute to the development and optimization of novel techniques and methodologies for vaccine response analysis. Collaborative Research & Project Contributions Support the isolation of novel therapeutic monoclonal antibodies from human Nipah virus survivors by providing purified recombinant glycoproteins. Present research updates at monthly consortium meetings and collaborate effectively with international research partners. Disseminate findings by preparing high-quality, peer-reviewed manuscripts and delivering presentations at scientific conferences. Maintain comprehensive health, safety, and biosecurity documentation to ensure a safe research environment. Assist in lab management tasks, including ordering supplies, maintaining equipment, and overseeing sample inventories. Due to the nature of the work we do, all successful applicants will be required to go through a comprehensive screening process including reference and qualification checks, financial and security clearances. Essential/Desirable requirements A PhD or equivalent in a relevant branch of biosciences An excellent record of research productivity, relative to experience Experience of recombinant protein and/or monoclonal antibody expression and purification Experience in immunology including analysis of antibody responses e.g. ELISAs and virus neutralisation assays and T cell responses e.g., flow cytometry Evidence of excellent oral and written communication skills Experience of vaccine/therapeutic antibody R&D Experience of working with large animals Experience of working with viruses Experience of working in international research consortia What we offer Generous Group Personal Pension Scheme and life cover (subject to age and earnings) 25 days annual leave per annum, pro rata, plus 10.5 public and privilege days Buy and sell annual leave Option to carry over up to two weeks annual leave Pirbright gym with subsidised membership Pirbright social club Pirbright Lifestyle Hub (employee discount site) Cycle to work Subsidised employee restaurant Childcare allowance Free onsite parking Electric car charging facilities Due to the high volume of applications we receive, if you have not heard from us within one month from closing date of the vacancy, then please contact us on for an update.
Feb 18, 2025
Full time
The Pirbright Institute delivers world-leading research to understand, predict, detect and respond to viral disease outbreaks. We study viruses of livestock that are endemic and exotic to the UK, including zoonotic viruses, by using the most advanced tools and technologies to understand host-pathogen interactions in animals and arthropod vectors. Our major strength in understanding the immune systems of livestock provides a platform to control current diseases and respond to emerging threats. Our Institute is made up of a dynamic and vibrant community of staff covering a diverse set of chosen fields, backgrounds and experience. We all play a crucial role in furthering the Institute's aspirations, advancing the frontiers of science and knowledge through our excellent scientific research, knowledge sharing and contribution; with a real focus in improving the world in which we live. Our outlook is always balanced by our strong sense of purpose, values and behaviours and an unwavering commitment to a 'one Institute' approach. Organisation position and purpose The Pirbright Institute is seeking a highly motivated Postdoctoral Scientist to join Professor Simon Graham's research group as part of an international team tackling Nipah virus, a high-priority zoonotic pathogen. This role is funded through the UKRI-Southeast Asia Collaboration on Infectious Diseases and offers an exciting opportunity to contribute to the development of next-generation vaccines and therapeutics. About the project: Titled "DNA-launched Nipah virus vaccines and therapeutics," this project aims to leverage our innovative DNA-delivery platform to create effective, affordable, and scalable interventions against Nipah virus. Our cutting-edge polymer/peptide nano-formulation technology enables efficient DNA vector delivery, presenting a promising and deployable vaccination and treatment strategy. The project is a collaboration between The Pirbright Institute, the University of Nottingham (UK), and the University of Malaya (Malaysia) and aims to generate the crucial preclinical efficacy data needed for further clinical translation. Professor Simon Graham will serve as the UK Project Lead and direct line manager for the postholder. This is a fantastic opportunity for a postdoctoral scientist passionate about virology, immunology, and translational research to make a tangible impact in global infectious disease control. Main duties and responsibilities: Preclinical Evaluation of DNA-Vectored Therapeutics & Vaccines Conduct pharmacokinetic studies on DNA-vectored therapeutic monoclonal antibodies and assess the immunogenicity of DNA-vectored vaccines in mice and pigs. Produce and purify key research materials, including recombinant Nipah virus glycoproteins, monoclonal antibodies, and pseudo viruses. Coordinate animal studies in collaboration with project partners and contract research organizations, ensuring adherence to study protocols. Analyse antibody responses using pseudovirus neutralization assays and ELISA techniques. Assess T cell responses through IFN-γ ELISpot assays and flow cytometric analysis. Contribute to the development and optimization of novel techniques and methodologies for vaccine response analysis. Collaborative Research & Project Contributions Support the isolation of novel therapeutic monoclonal antibodies from human Nipah virus survivors by providing purified recombinant glycoproteins. Present research updates at monthly consortium meetings and collaborate effectively with international research partners. Disseminate findings by preparing high-quality, peer-reviewed manuscripts and delivering presentations at scientific conferences. Maintain comprehensive health, safety, and biosecurity documentation to ensure a safe research environment. Assist in lab management tasks, including ordering supplies, maintaining equipment, and overseeing sample inventories. Due to the nature of the work we do, all successful applicants will be required to go through a comprehensive screening process including reference and qualification checks, financial and security clearances. Essential/Desirable requirements A PhD or equivalent in a relevant branch of biosciences An excellent record of research productivity, relative to experience Experience of recombinant protein and/or monoclonal antibody expression and purification Experience in immunology including analysis of antibody responses e.g. ELISAs and virus neutralisation assays and T cell responses e.g., flow cytometry Evidence of excellent oral and written communication skills Experience of vaccine/therapeutic antibody R&D Experience of working with large animals Experience of working with viruses Experience of working in international research consortia What we offer Generous Group Personal Pension Scheme and life cover (subject to age and earnings) 25 days annual leave per annum, pro rata, plus 10.5 public and privilege days Buy and sell annual leave Option to carry over up to two weeks annual leave Pirbright gym with subsidised membership Pirbright social club Pirbright Lifestyle Hub (employee discount site) Cycle to work Subsidised employee restaurant Childcare allowance Free onsite parking Electric car charging facilities Due to the high volume of applications we receive, if you have not heard from us within one month from closing date of the vacancy, then please contact us on for an update.
