Postdoctoral Researcher (Foraminifera Geochemist) Postdoc Researcher Scroll down to read more: Rehemat Job title: Postdoctoral Researcher - Foraminifera Geochemist What does a Foraminifera Geochemist do? I am a hybrid micropalaeontologist and geochemist. A micropalaeontologist studies microscopic fossils, and a geochemist analyses the chemistry of geological materials. I use the chemistry of fossil species of foraminifera, a type of plankton with a calcium carbonate skeleton, to understand more about their ecologies and climate millions of years ago (palaeoclimatology). Different chemical elements can help me understand how hot the oceans were, whether some species of plankton lived closer to the surface of the ocean or further down in the water column, and even how much ice there was on land! I wash sediment samples, identify the plankton hiding inside, then analyse them for their chemistry and try to understand the data they produce. What formal qualifications and previous work experience did you need to get your job? When I was a teenager I did some work experience at the Natural History Museum, London and The Royal Geographical Society. Having had a super positive introduction to Earth Sciences through these experiences, I decided to do an undergraduate MSci degree in Geoscience at Royal Holloway (University of London). During my undergraduate degree I did several internships. I interned at a structural geology company, biostratigraphy company and a summer research internship focused around foraminifera and palaeoclimatology working with a PhD student in Kiel, Germany. I also volunteered at the Natural History Museum throughout the final years of my undergraduate degree. These last two experiences made me realise I could combine my love of geochemistry and ocean sciences, and I subsequently decided to do a PhD at University College London. What other skills or characteristics do you need in your job? Always be curious Always be persistent Understand how to communicate your science to non-specialists in an enthusiastic way Have good attention to detail for taxonomy Know the importance of collaboration and networking. You never know when your mass spectrometer will break and you will need to contact another lab to use their instrument! What sort of organisation do you work for? Where else could you work as a Foraminifera Geochemist? I work at a university, but those with my background can also work in many different sectors, including the oil industry (as a biostratigrapher, using foraminfera to date rock formations), analytical instrument companies, science policy and publishers. Science communication is also popular, but this is definitely applicable as a career path across geological facets! Working in the third sector (i.e. with charities and NGOs) within Trusts and Foundations/Major Donor Fundraising is also possible, because all researchers have the ability to network, collaborate, project manage, build relationships with others and write grant applications concisely. What do you enjoy about your job? Foraminifera are beautiful and each time I have microscope work to do it is a joy to see them. I enjoy being able to talk with young people about what I do. It's really rewarding to inspire the generation to go into STEM and sometimes even helps me figure out what my data mean! I like how no two days are the same. Sometimes I'm doing labwork, sometimes I am writing and sometimes I am reading about all the new and exciting science that is going on in the field. Whilst the dynamic-ness of being a researcher can sometimes be challenging in terms of work/life balance, my lab group are really supportive and I'm so lucky to be working with them. What opportunities do you have to develop your skills in your job? In my postdoc and PhD, I went to summer schools and workshops focused around Earth and ocean sciences in some really cool places, including Israel and Italy. I also went to international conferences to present my data, and regularly did outreach presentations to young people. I also had the opportunity to attend workshops focused around science policy and diversity and inclusion in the geosciences. It's definitely important to go to a variety of professional development courses, because if researchers decide academia is not for them at any point in their career, they have evidence that they have some training for other sectors. What advice or extra information do you wish you'd had before starting this career? Writing is a big part of being an academic, and it can be really challenging. But the first draft of anything will never be perfect, and words down on paper is much better than no words at all! No two days are the same when you are a geoscientist. Even if you don't pass an exam early on during undergrad, this doesn't define who you are. There are always more opportunities to do better next time. When you say you're a geologist, sometimes people will be surprised by this. But it's not weird to like rocks and fossils. Geologists and ocean scientists study some of the oldest things on the Earth, go to some absolutely amazing places (for work!), and unravel the stories of the world around them.
Jul 03, 2025
Full time
Postdoctoral Researcher (Foraminifera Geochemist) Postdoc Researcher Scroll down to read more: Rehemat Job title: Postdoctoral Researcher - Foraminifera Geochemist What does a Foraminifera Geochemist do? I am a hybrid micropalaeontologist and geochemist. A micropalaeontologist studies microscopic fossils, and a geochemist analyses the chemistry of geological materials. I use the chemistry of fossil species of foraminifera, a type of plankton with a calcium carbonate skeleton, to understand more about their ecologies and climate millions of years ago (palaeoclimatology). Different chemical elements can help me understand how hot the oceans were, whether some species of plankton lived closer to the surface of the ocean or further down in the water column, and even how much ice there was on land! I wash sediment samples, identify the plankton hiding inside, then analyse them for their chemistry and try to understand the data they produce. What formal qualifications and previous work experience did you need to get your job? When I was a teenager I did some work experience at the Natural History Museum, London and The Royal Geographical Society. Having had a super positive introduction to Earth Sciences through these experiences, I decided to do an undergraduate MSci degree in Geoscience at Royal Holloway (University of London). During my undergraduate degree I did several internships. I interned at a structural geology company, biostratigraphy company and a summer research internship focused around foraminifera and palaeoclimatology working with a PhD student in Kiel, Germany. I also volunteered at the Natural History Museum throughout the final years of my undergraduate degree. These last two experiences made me realise I could combine my love of geochemistry and ocean sciences, and I subsequently decided to do a PhD at University College London. What other skills or characteristics do you need in your job? Always be curious Always be persistent Understand how to communicate your science to non-specialists in an enthusiastic way Have good attention to detail for taxonomy Know the importance of collaboration and networking. You never know when your mass spectrometer will break and you will need to contact another lab to use their instrument! What sort of organisation do you work for? Where else could you work as a Foraminifera Geochemist? I work at a university, but those with my background can also work in many different sectors, including the oil industry (as a biostratigrapher, using foraminfera to date rock formations), analytical instrument companies, science policy and publishers. Science communication is also popular, but this is definitely applicable as a career path across geological facets! Working in the third sector (i.e. with charities and NGOs) within Trusts and Foundations/Major Donor Fundraising is also possible, because all researchers have the ability to network, collaborate, project manage, build relationships with others and write grant applications concisely. What do you enjoy about your job? Foraminifera are beautiful and each time I have microscope work to do it is a joy to see them. I enjoy being able to talk with young people about what I do. It's really rewarding to inspire the generation to go into STEM and sometimes even helps me figure out what my data mean! I like how no two days are the same. Sometimes I'm doing labwork, sometimes I am writing and sometimes I am reading about all the new and exciting science that is going on in the field. Whilst the dynamic-ness of being a researcher can sometimes be challenging in terms of work/life balance, my lab group are really supportive and I'm so lucky to be working with them. What opportunities do you have to develop your skills in your job? In my postdoc and PhD, I went to summer schools and workshops focused around Earth and ocean sciences in some really cool places, including Israel and Italy. I also went to international conferences to present my data, and regularly did outreach presentations to young people. I also had the opportunity to attend workshops focused around science policy and diversity and inclusion in the geosciences. It's definitely important to go to a variety of professional development courses, because if researchers decide academia is not for them at any point in their career, they have evidence that they have some training for other sectors. What advice or extra information do you wish you'd had before starting this career? Writing is a big part of being an academic, and it can be really challenging. But the first draft of anything will never be perfect, and words down on paper is much better than no words at all! No two days are the same when you are a geoscientist. Even if you don't pass an exam early on during undergrad, this doesn't define who you are. There are always more opportunities to do better next time. When you say you're a geologist, sometimes people will be surprised by this. But it's not weird to like rocks and fossils. Geologists and ocean scientists study some of the oldest things on the Earth, go to some absolutely amazing places (for work!), and unravel the stories of the world around them.
Job ID: Amazon Development Centre (London) Limited Amazon is looking for talented Postdoctoral Scientists to join our team for a one-year, full-time research position. Postdoctoral Scientists will innovate in key areas of machine learning, natural language processing, computer vision, automated reasoning, robotics, or quantum technologies. As part of the Rufus Features Science team in London, the postdoc will work on shaping the future of AI-driven shopping experiences at Amazon. In particular, the project focuses on conversational search in shopping, developing next-generation conversational search systems in the shopping domain that seamlessly bridge natural shopping dialogues with precise product retrieval and recommendation. Key challenges include developing new methods for grounding conversational context in product attribute space, designing efficient retrieval mechanisms that can handle both structured product metadata and unstructured conversational context, and creating evaluation frameworks that capture both conversation quality and search relevance. The project will extend beyond traditional conversational search paradigms by integrating agentic frameworks that can proactively identify, clarify, and refine user needs through strategic dialogue management, while simultaneously orchestrating multiple specialized retrieval agents for different aspects of the shopping journey (e.g., attribute extraction, price comparison, review analysis, and specification matching). We experiment and innovate relentlessly. Science is core in our offering to shoppers, advertisers and customers. Our scientists apply machine learning, optimization, causal modeling and game theory at scale to enhance the customer experience, help advertisers reach relevant audiences, and support brand building. We are seeking talented scientists to invent cutting-edge techniques in a variety of areas and innovate on behalf of shoppers, advertisers, and customers. In this role you will: Lead research projects in conversational search and retrieval-augmented systems Develop novel architectures combining dialogue management with product search Design and implement evaluation frameworks for agentic conversational shopping systems Publish research findings in top-tier conferences and journals Mentor junior researchers and contribute to the team's scientific direction BASIC QUALIFICATIONS PhD in Computer Science, Machine Learning, Information Retrieval or related field Strong publication record in NLP, Information Retrieval, or Conversational AI Experience with large language models and retrieval-augmented generation Research background in conversational systems or dialogue management Experience with modern deep learning frameworks (PyTorch, TensorFlow) Excellent written and verbal communication skills PREFERRED QUALIFICATIONS Knowledge of multi-agent systems and tool-use frameworks Experience with e-commerce or shopping domain applications Publications at top venues (ACL, NeurIPS, SIGIR, AAAI, etc.) Amazon is an equal opportunities employer. We believe passionately that employing a diverse workforce is central to our success. We make recruiting decisions based on your experience and skills. We value your passion to discover, invent, simplify and build. Protecting your privacy and the security of your data is a longstanding top priority for Amazon. Please consult our Privacy Notice ( ) to know more about how we collect, use and transfer the personal data of our candidates. Amazon is an equal opportunity employer and does not discriminate on the basis of protected veteran status, disability, or other legally protected status. Our inclusive culture empowers Amazonians to deliver the best results for our customers. If you have a disability and need a workplace accommodation or adjustment during the application and hiring process, including support for the interview or onboarding process, please visit for more information. If the country/region you're applying in isn't listed, please contact your Recruiting Partner. Posted: May 16, 2025 (Updated 2 days ago) Posted: May 19, 2025 (Updated 4 days ago) Posted: April 16, 2025 (Updated 8 days ago) Posted: April 11, 2025 (Updated 8 days ago) Amazon is an equal opportunity employer and does not discriminate on the basis of protected veteran status, disability, or other legally protected status.
Jul 03, 2025
Full time
Job ID: Amazon Development Centre (London) Limited Amazon is looking for talented Postdoctoral Scientists to join our team for a one-year, full-time research position. Postdoctoral Scientists will innovate in key areas of machine learning, natural language processing, computer vision, automated reasoning, robotics, or quantum technologies. As part of the Rufus Features Science team in London, the postdoc will work on shaping the future of AI-driven shopping experiences at Amazon. In particular, the project focuses on conversational search in shopping, developing next-generation conversational search systems in the shopping domain that seamlessly bridge natural shopping dialogues with precise product retrieval and recommendation. Key challenges include developing new methods for grounding conversational context in product attribute space, designing efficient retrieval mechanisms that can handle both structured product metadata and unstructured conversational context, and creating evaluation frameworks that capture both conversation quality and search relevance. The project will extend beyond traditional conversational search paradigms by integrating agentic frameworks that can proactively identify, clarify, and refine user needs through strategic dialogue management, while simultaneously orchestrating multiple specialized retrieval agents for different aspects of the shopping journey (e.g., attribute extraction, price comparison, review analysis, and specification matching). We experiment and innovate relentlessly. Science is core in our offering to shoppers, advertisers and customers. Our scientists apply machine learning, optimization, causal modeling and game theory at scale to enhance the customer experience, help advertisers reach relevant audiences, and support brand building. We are seeking talented scientists to invent cutting-edge techniques in a variety of areas and innovate on behalf of shoppers, advertisers, and customers. In this role you will: Lead research projects in conversational search and retrieval-augmented systems Develop novel architectures combining dialogue management with product search Design and implement evaluation frameworks for agentic conversational shopping systems Publish research findings in top-tier conferences and journals Mentor junior researchers and contribute to the team's scientific direction BASIC QUALIFICATIONS PhD in Computer Science, Machine Learning, Information Retrieval or related field Strong publication record in NLP, Information Retrieval, or Conversational AI Experience with large language models and retrieval-augmented generation Research background in conversational systems or dialogue management Experience with modern deep learning frameworks (PyTorch, TensorFlow) Excellent written and verbal communication skills PREFERRED QUALIFICATIONS Knowledge of multi-agent systems and tool-use frameworks Experience with e-commerce or shopping domain applications Publications at top venues (ACL, NeurIPS, SIGIR, AAAI, etc.) Amazon is an equal opportunities employer. We believe passionately that employing a diverse workforce is central to our success. We make recruiting decisions based on your experience and skills. We value your passion to discover, invent, simplify and build. Protecting your privacy and the security of your data is a longstanding top priority for Amazon. Please consult our Privacy Notice ( ) to know more about how we collect, use and transfer the personal data of our candidates. Amazon is an equal opportunity employer and does not discriminate on the basis of protected veteran status, disability, or other legally protected status. Our inclusive culture empowers Amazonians to deliver the best results for our customers. If you have a disability and need a workplace accommodation or adjustment during the application and hiring process, including support for the interview or onboarding process, please visit for more information. If the country/region you're applying in isn't listed, please contact your Recruiting Partner. Posted: May 16, 2025 (Updated 2 days ago) Posted: May 19, 2025 (Updated 4 days ago) Posted: April 16, 2025 (Updated 8 days ago) Posted: April 11, 2025 (Updated 8 days ago) Amazon is an equal opportunity employer and does not discriminate on the basis of protected veteran status, disability, or other legally protected status.
Senior Laboratory Research Scientist (SLRS) - Crystallography/Drug Discovery About us The Francis Crick Institute is Europe's largest biomedical research institute under one roof. Our world-class scientists and staff collaborate on vital research to help prevent, diagnose and treat illnesses such as cancer, heart disease, infectious diseases and neurodegenerative conditions. The Crick is a place for collaboration, innovation and exploration across many disciplines. A space where the brightest minds can pursue big and bold ideas and discover answers to crucial scientific questions. We support them in a dynamic environment which fosters excellence with state-of-the-art infrastructure, cutting-edge facilities, and a creative and curious culture. We've removed traditional boundaries of departments, divisions and disciplines and instead have an open approach that supports every researcher. This gives us the freedom to take risks and carry out high-quality, pioneering research. Creating a space for discovery without boundaries helps us to turn our science into benefits for human health and the economy. About the role This exciting research project is a cross-Francis Crick Institute collaboration focusing on the translation of cutting-edge research led by Dr. Simon Boulton in the Double Strand Break (DSB) Metabolism Laboratory. Researchers in this lab have identified cellular processes contributing to the alternative lengthening of telomeres (ALT) mechanism in certain cancers. This collaboration aims to translate these insights into therapies for ALT-positive cancers. The position offers experience in drug discovery interfaced with disease biology, guided by experts in pharmaceutical research and DNA Damage Repair. This work is funded through a 3-year £3M programme supported by the philanthropic Chris Banton fund and LifeArc. The project involves a team of scientists across several laboratories and technology platforms at the Crick. What you will be doing We seek a creative, motivated structural biologist with a strong background in crystallography and drug discovery to support early-stage drug probe development on the ALT project. You will work within the Structural Biology Science Technology Platform (SB STP), which covers protein expression, purification, biophysics, X-ray crystallography, and cryo-EM. You will be responsible for all aspects of protein structure determination, including sample prep, data collection, processing, structure determination, and data presentation. You are expected to contribute to ongoing projects and process improvements. As a Senior Laboratory Research Scientist at the Crick, you will: Develop robust purification protocols for high-quality recombinant proteins for structural studies. Determine crystal structures of target proteins with bound fragments/compounds. Train and supervise junior team members or students. Maintain up-to-date knowledge of relevant literature, communicate key developments, and implement new techniques. About you You will bring: PhD in structural biology with postdoctoral or equivalent experience. Extensive experience in molecular cloning, recombinant protein expression, and purification using ÄKTA systems and chromatographic techniques. Expertise in biophysical quality control methods for crystallography-grade proteins. Experience in X-ray crystallography, including crystallization, data collection, structure determination, and refinement, using robots like Mosquito and NT8. Proficiency with crystallographic software such as CCP4, CCP4cloud, Phenix, and Coot. Deep knowledge of high-throughput crystallography techniques.
Jul 03, 2025
Full time
Senior Laboratory Research Scientist (SLRS) - Crystallography/Drug Discovery About us The Francis Crick Institute is Europe's largest biomedical research institute under one roof. Our world-class scientists and staff collaborate on vital research to help prevent, diagnose and treat illnesses such as cancer, heart disease, infectious diseases and neurodegenerative conditions. The Crick is a place for collaboration, innovation and exploration across many disciplines. A space where the brightest minds can pursue big and bold ideas and discover answers to crucial scientific questions. We support them in a dynamic environment which fosters excellence with state-of-the-art infrastructure, cutting-edge facilities, and a creative and curious culture. We've removed traditional boundaries of departments, divisions and disciplines and instead have an open approach that supports every researcher. This gives us the freedom to take risks and carry out high-quality, pioneering research. Creating a space for discovery without boundaries helps us to turn our science into benefits for human health and the economy. About the role This exciting research project is a cross-Francis Crick Institute collaboration focusing on the translation of cutting-edge research led by Dr. Simon Boulton in the Double Strand Break (DSB) Metabolism Laboratory. Researchers in this lab have identified cellular processes contributing to the alternative lengthening of telomeres (ALT) mechanism in certain cancers. This collaboration aims to translate these insights into therapies for ALT-positive cancers. The position offers experience in drug discovery interfaced with disease biology, guided by experts in pharmaceutical research and DNA Damage Repair. This work is funded through a 3-year £3M programme supported by the philanthropic Chris Banton fund and LifeArc. The project involves a team of scientists across several laboratories and technology platforms at the Crick. What you will be doing We seek a creative, motivated structural biologist with a strong background in crystallography and drug discovery to support early-stage drug probe development on the ALT project. You will work within the Structural Biology Science Technology Platform (SB STP), which covers protein expression, purification, biophysics, X-ray crystallography, and cryo-EM. You will be responsible for all aspects of protein structure determination, including sample prep, data collection, processing, structure determination, and data presentation. You are expected to contribute to ongoing projects and process improvements. As a Senior Laboratory Research Scientist at the Crick, you will: Develop robust purification protocols for high-quality recombinant proteins for structural studies. Determine crystal structures of target proteins with bound fragments/compounds. Train and supervise junior team members or students. Maintain up-to-date knowledge of relevant literature, communicate key developments, and implement new techniques. About you You will bring: PhD in structural biology with postdoctoral or equivalent experience. Extensive experience in molecular cloning, recombinant protein expression, and purification using ÄKTA systems and chromatographic techniques. Expertise in biophysical quality control methods for crystallography-grade proteins. Experience in X-ray crystallography, including crystallization, data collection, structure determination, and refinement, using robots like Mosquito and NT8. Proficiency with crystallographic software such as CCP4, CCP4cloud, Phenix, and Coot. Deep knowledge of high-throughput crystallography techniques.
We are looking for an advanced chemist to join our team to train AI models. You will measure the progress of these AI chatbots, evaluate their logic, and solve problems to improve the quality of each model. In this role you will need to hold an expert understanding of chemistry- a completed or in progress Masters/PhD is preferred but not required. Other related fields include, but are not limited to: Postdoctoral Researcher, Formulation Scientist, Development Chemist, Analytical Chemist, Chemical Engineer, Medicinal Chemist, Biochemist, Process Development Chemist. Benefits: This is a full-time or part-time REMOTE position You'll be able to choose which projects you want to work on You can work on your own schedule Projects are paid hourly starting at $40+ USD per hour, with bonuses on high-quality and high-volume work Responsibilities: Give AI chatbots diverse and complex chemistry problems and evaluate their outputs Evaluate the quality produced by AI models for correctness and performance Qualifications: A current, in progress, or completed Masters and/or PhD is preferred but not required Fluency in English (native or bilingual level) Detail-oriented Proficient in chemistry, inductive/deductive reasoning, physical/temporal/ spatial reasoning Note: Payment is made via PayPal. We will never ask for any money from you. PayPal will handle any currency conversions from USD. This job is only available to those in the US, UK, Canada, Australia, or New Zealand. Those located outside of these countries will not see work or assessments available on our site at this time. Job Types: Full-time, Part-time Pay: From £29.06 per hour Expected hours: 1 - 40 per week Work Location: Remote
Jul 02, 2025
Full time
We are looking for an advanced chemist to join our team to train AI models. You will measure the progress of these AI chatbots, evaluate their logic, and solve problems to improve the quality of each model. In this role you will need to hold an expert understanding of chemistry- a completed or in progress Masters/PhD is preferred but not required. Other related fields include, but are not limited to: Postdoctoral Researcher, Formulation Scientist, Development Chemist, Analytical Chemist, Chemical Engineer, Medicinal Chemist, Biochemist, Process Development Chemist. Benefits: This is a full-time or part-time REMOTE position You'll be able to choose which projects you want to work on You can work on your own schedule Projects are paid hourly starting at $40+ USD per hour, with bonuses on high-quality and high-volume work Responsibilities: Give AI chatbots diverse and complex chemistry problems and evaluate their outputs Evaluate the quality produced by AI models for correctness and performance Qualifications: A current, in progress, or completed Masters and/or PhD is preferred but not required Fluency in English (native or bilingual level) Detail-oriented Proficient in chemistry, inductive/deductive reasoning, physical/temporal/ spatial reasoning Note: Payment is made via PayPal. We will never ask for any money from you. PayPal will handle any currency conversions from USD. This job is only available to those in the US, UK, Canada, Australia, or New Zealand. Those located outside of these countries will not see work or assessments available on our site at this time. Job Types: Full-time, Part-time Pay: From £29.06 per hour Expected hours: 1 - 40 per week Work Location: Remote
We are looking for an advanced chemist to join our team to train AI models. You will measure the progress of these AI chatbots, evaluate their logic, and solve problems to improve the quality of each model. In this role you will need to hold an expert understanding of chemistry- a completed or in progress Masters/PhD is preferred but not required. Other related fields include, but are not limited to: Formulation Scientist, Development Chemist, Analytical Chemist, Chemical Engineer, Medicinal Chemist, Biochemist, Process Development Chemist. Benefits: This is a full-time or part-time REMOTE position You'll be able to choose which projects you want to work on You can work on your own schedule Projects are paid hourly starting at $40+ USD per hour, with bonuses on high-quality and high-volume work Responsibilities: Give AI chatbots diverse and complex chemistry problems and evaluate their outputs Evaluate the quality produced by AI models for correctness and performance Qualifications: A current, in progress, or completed Masters and/or PhD is preferred but not required Fluency in English (native or bilingual level) Detail-oriented Proficient in chemistry and inductive/deductive reasoning, physical/temporal/ spatial reasoning Note: Payment is made via PayPal. We will never ask for any money from you. PayPal will handle any currency conversions from USD. Job Types: Full-time, Part-time Pay: From £29.06 per hour Work Location: Remote
Jul 02, 2025
Full time
We are looking for an advanced chemist to join our team to train AI models. You will measure the progress of these AI chatbots, evaluate their logic, and solve problems to improve the quality of each model. In this role you will need to hold an expert understanding of chemistry- a completed or in progress Masters/PhD is preferred but not required. Other related fields include, but are not limited to: Formulation Scientist, Development Chemist, Analytical Chemist, Chemical Engineer, Medicinal Chemist, Biochemist, Process Development Chemist. Benefits: This is a full-time or part-time REMOTE position You'll be able to choose which projects you want to work on You can work on your own schedule Projects are paid hourly starting at $40+ USD per hour, with bonuses on high-quality and high-volume work Responsibilities: Give AI chatbots diverse and complex chemistry problems and evaluate their outputs Evaluate the quality produced by AI models for correctness and performance Qualifications: A current, in progress, or completed Masters and/or PhD is preferred but not required Fluency in English (native or bilingual level) Detail-oriented Proficient in chemistry and inductive/deductive reasoning, physical/temporal/ spatial reasoning Note: Payment is made via PayPal. We will never ask for any money from you. PayPal will handle any currency conversions from USD. Job Types: Full-time, Part-time Pay: From £29.06 per hour Work Location: Remote
We are looking for an advanced chemist to join our team to train AI models. You will measure the progress of these AI chatbots, evaluate their logic, and solve problems to improve the quality of each model. In this role you will need to hold an expert understanding of chemistry- a completed or in progress Masters/PhD is preferred but not required. Other related fields include, but are not limited to: Formulation Scientist, Development Chemist, Analytical Chemist, Chemical Engineer, Medicinal Chemist, Biochemist, Process Development Chemist. Benefits: This is a full-time or part-time REMOTE position You'll be able to choose which projects you want to work on You can work on your own schedule Projects are paid hourly starting at $40+ USD per hour, with bonuses on high-quality and high-volume work Responsibilities: Give AI chatbots diverse and complex chemistry problems and evaluate their outputs Evaluate the quality produced by AI models for correctness and performance Qualifications: A current, in progress, or completed Masters and/or PhD is preferred but not required Fluency in English (native or bilingual level) Detail-oriented Proficient in chemistry and inductive/deductive reasoning, physical/temporal/ spatial reasoning Note: Payment is made via PayPal. We will never ask for any money from you. PayPal will handle any currency conversions from USD. Job Types: Full-time, Part-time Pay: From £29.06 per hour Work Location: Remote
Jul 02, 2025
Full time
We are looking for an advanced chemist to join our team to train AI models. You will measure the progress of these AI chatbots, evaluate their logic, and solve problems to improve the quality of each model. In this role you will need to hold an expert understanding of chemistry- a completed or in progress Masters/PhD is preferred but not required. Other related fields include, but are not limited to: Formulation Scientist, Development Chemist, Analytical Chemist, Chemical Engineer, Medicinal Chemist, Biochemist, Process Development Chemist. Benefits: This is a full-time or part-time REMOTE position You'll be able to choose which projects you want to work on You can work on your own schedule Projects are paid hourly starting at $40+ USD per hour, with bonuses on high-quality and high-volume work Responsibilities: Give AI chatbots diverse and complex chemistry problems and evaluate their outputs Evaluate the quality produced by AI models for correctness and performance Qualifications: A current, in progress, or completed Masters and/or PhD is preferred but not required Fluency in English (native or bilingual level) Detail-oriented Proficient in chemistry and inductive/deductive reasoning, physical/temporal/ spatial reasoning Note: Payment is made via PayPal. We will never ask for any money from you. PayPal will handle any currency conversions from USD. Job Types: Full-time, Part-time Pay: From £29.06 per hour Work Location: Remote
We are looking for an advanced chemist to join our team to train AI models. You will measure the progress of these AI chatbots, evaluate their logic, and solve problems to improve the quality of each model. In this role you will need to hold an expert understanding of chemistry- a completed or in progress Masters/PhD is preferred but not required. Other related fields include, but are not limited to: Formulation Scientist, Development Chemist, Analytical Chemist, Chemical Engineer, Medicinal Chemist, Biochemist, Process Development Chemist. Benefits: This is a full-time or part-time REMOTE position You'll be able to choose which projects you want to work on You can work on your own schedule Projects are paid hourly starting at $40+ USD per hour, with bonuses on high-quality and high-volume work Responsibilities: Give AI chatbots diverse and complex chemistry problems and evaluate their outputs Evaluate the quality produced by AI models for correctness and performance Qualifications: A current, in progress, or completed Masters and/or PhD is preferred but not required Fluency in English (native or bilingual level) Detail-oriented Proficient in chemistry and inductive/deductive reasoning, physical/temporal/ spatial reasoning Note: Payment is made via PayPal. We will never ask for any money from you. PayPal will handle any currency conversions from USD. Job Types: Full-time, Part-time Pay: From £29.06 per hour Work Location: Remote
Jul 02, 2025
Full time
We are looking for an advanced chemist to join our team to train AI models. You will measure the progress of these AI chatbots, evaluate their logic, and solve problems to improve the quality of each model. In this role you will need to hold an expert understanding of chemistry- a completed or in progress Masters/PhD is preferred but not required. Other related fields include, but are not limited to: Formulation Scientist, Development Chemist, Analytical Chemist, Chemical Engineer, Medicinal Chemist, Biochemist, Process Development Chemist. Benefits: This is a full-time or part-time REMOTE position You'll be able to choose which projects you want to work on You can work on your own schedule Projects are paid hourly starting at $40+ USD per hour, with bonuses on high-quality and high-volume work Responsibilities: Give AI chatbots diverse and complex chemistry problems and evaluate their outputs Evaluate the quality produced by AI models for correctness and performance Qualifications: A current, in progress, or completed Masters and/or PhD is preferred but not required Fluency in English (native or bilingual level) Detail-oriented Proficient in chemistry and inductive/deductive reasoning, physical/temporal/ spatial reasoning Note: Payment is made via PayPal. We will never ask for any money from you. PayPal will handle any currency conversions from USD. Job Types: Full-time, Part-time Pay: From £29.06 per hour Work Location: Remote
We are looking for an advanced chemist to join our team to train AI models. You will measure the progress of these AI chatbots, evaluate their logic, and solve problems to improve the quality of each model. In this role you will need to hold an expert understanding of chemistry- a completed or in progress Masters/PhD is preferred but not required. Other related fields include, but are not limited to: Formulation Scientist, Development Chemist, Analytical Chemist, Chemical Engineer, Medicinal Chemist, Biochemist, Process Development Chemist. Benefits: This is a full-time or part-time REMOTE position You'll be able to choose which projects you want to work on You can work on your own schedule Projects are paid hourly starting at $40+ USD per hour, with bonuses on high-quality and high-volume work Responsibilities: Give AI chatbots diverse and complex chemistry problems and evaluate their outputs Evaluate the quality produced by AI models for correctness and performance Qualifications: A current, in progress, or completed Masters and/or PhD is preferred but not required Fluency in English (native or bilingual level) Detail-oriented Proficient in chemistry and inductive/deductive reasoning, physical/temporal/ spatial reasoning Note: Payment is made via PayPal. We will never ask for any money from you. PayPal will handle any currency conversions from USD. Job Types: Full-time, Part-time Pay: From £29.06 per hour Work Location: Remote
Jul 02, 2025
Full time
We are looking for an advanced chemist to join our team to train AI models. You will measure the progress of these AI chatbots, evaluate their logic, and solve problems to improve the quality of each model. In this role you will need to hold an expert understanding of chemistry- a completed or in progress Masters/PhD is preferred but not required. Other related fields include, but are not limited to: Formulation Scientist, Development Chemist, Analytical Chemist, Chemical Engineer, Medicinal Chemist, Biochemist, Process Development Chemist. Benefits: This is a full-time or part-time REMOTE position You'll be able to choose which projects you want to work on You can work on your own schedule Projects are paid hourly starting at $40+ USD per hour, with bonuses on high-quality and high-volume work Responsibilities: Give AI chatbots diverse and complex chemistry problems and evaluate their outputs Evaluate the quality produced by AI models for correctness and performance Qualifications: A current, in progress, or completed Masters and/or PhD is preferred but not required Fluency in English (native or bilingual level) Detail-oriented Proficient in chemistry and inductive/deductive reasoning, physical/temporal/ spatial reasoning Note: Payment is made via PayPal. We will never ask for any money from you. PayPal will handle any currency conversions from USD. Job Types: Full-time, Part-time Pay: From £29.06 per hour Work Location: Remote
We are looking for an advanced chemist to join our team to train AI models. You will measure the progress of these AI chatbots, evaluate their logic, and solve problems to improve the quality of each model. In this role you will need to hold an expert understanding of chemistry- a completed or in progress Masters/PhD is preferred but not required. Other related fields include, but are not limited to: Formulation Scientist, Development Chemist, Analytical Chemist, Chemical Engineer, Medicinal Chemist, Biochemist, Process Development Chemist. Benefits: This is a full-time or part-time REMOTE position You'll be able to choose which projects you want to work on You can work on your own schedule Projects are paid hourly starting at $40+ USD per hour, with bonuses on high-quality and high-volume work Responsibilities: Give AI chatbots diverse and complex chemistry problems and evaluate their outputs Evaluate the quality produced by AI models for correctness and performance Qualifications: A current, in progress, or completed Masters and/or PhD is preferred but not required Fluency in English (native or bilingual level) Detail-oriented Proficient in chemistry and inductive/deductive reasoning, physical/temporal/ spatial reasoning Note: Payment is made via PayPal. We will never ask for any money from you. PayPal will handle any currency conversions from USD. Job Types: Full-time, Part-time Pay: From £29.06 per hour Work Location: Remote
Jul 02, 2025
Full time
We are looking for an advanced chemist to join our team to train AI models. You will measure the progress of these AI chatbots, evaluate their logic, and solve problems to improve the quality of each model. In this role you will need to hold an expert understanding of chemistry- a completed or in progress Masters/PhD is preferred but not required. Other related fields include, but are not limited to: Formulation Scientist, Development Chemist, Analytical Chemist, Chemical Engineer, Medicinal Chemist, Biochemist, Process Development Chemist. Benefits: This is a full-time or part-time REMOTE position You'll be able to choose which projects you want to work on You can work on your own schedule Projects are paid hourly starting at $40+ USD per hour, with bonuses on high-quality and high-volume work Responsibilities: Give AI chatbots diverse and complex chemistry problems and evaluate their outputs Evaluate the quality produced by AI models for correctness and performance Qualifications: A current, in progress, or completed Masters and/or PhD is preferred but not required Fluency in English (native or bilingual level) Detail-oriented Proficient in chemistry and inductive/deductive reasoning, physical/temporal/ spatial reasoning Note: Payment is made via PayPal. We will never ask for any money from you. PayPal will handle any currency conversions from USD. Job Types: Full-time, Part-time Pay: From £29.06 per hour Work Location: Remote
External Advertising End Date Advertising End Date: Salary: £47,400 per year. This role is eligible for ICR Sponsorship. Support will be provided for costs associated with Visa application. If you are considering relocating to the UK. Duration of Contract: Fixed Term for 12 months Hours per week: 35 hours per week (Full Time) Location: Sutton Closing Date: 31 July 2025 Please note: We reserve the right to close this vacancy early if we receive a high volume of applications. We recommend submitting your application as soon as possible to ensure it is considered. Under the guidance of Dr Alec Paschalis, we are seeking to recruit a Postdoctoral Training Fellow to contribute to cutting-edge research aimed at understanding how advanced cancers adapt and develop resistance to treatment. The purpose of this role is to drive the development of novel therapeutic strategies and improve existing standards of care. The successful candidate will play a key role in leading and executing laboratory-based research projects, including conducting functional assays on cancer models, analysing molecular data, supporting manuscript and grant preparation, and contributing to the overall management and collaborative activities of the Translational and Experimental Medicine Group. About you The successful candidate must have: BSc in biological sciences (first honours), PhD in biological sciences (submitted). Experience in molecular biology cancer research Practical skills for cell culture and molecular biology techniques. Problem-solving skills, ability to organise and prioritise work to meet deadlines. Work independently and as part of a team. Enthusiasm to work in an interdisciplinary environment towards the goal of developing improves cancer therapies. Candidates who are nearing completion of their PhD may apply, but confirmation on awarded PhD is required within 6 months of employment. The ICR has a workforce agreement stating that Postdoctoral Training Fellows can only be employed for up to 7 years as PDTF at the ICR, providing total postdoctoral experience (including previous employment at this level elsewhere) does not exceed 7 years. For general information on Postdocs atThe ICR, more informationcan be foundhere . Department/Directorate Information : The Translational and Experimental Medicine Group Clinical Studies Division Dr Alec Paschalis is a Clinician Scientist and Leader of the Translational and Experimental Medicine Group. His research team is focused on identifying therapeutic vulnerabilities in advanced cancers to drive the development of novel biology driven 'Proof of Concept' and 'Proof of Mechanism' clinical studies and improve the outcomes for patients with cancer. This new team will consist of basic and clinical scientists and will be embedded in a vibrant world-class research environment. What we offer A dynamic and supportive research environment Access to state-of-the-art facilities and professional development opportunities Collaboration with leading researchers in the field Competitive salary and pension We encourage all applicants to access the job pack attached for more detailed information regarding this role. For an informal discussion regarding the role, please contact Dr Alec Paschalis via About The Institute of Cancer Research Why work for us? As a member of staff, you'll have exclusive access to a range ofstaff benefits . The ICR is committed to supporting overseas applicants applying for roles,please click here to find out further information. The Institute of Cancer Research, London, is one of the world's most influential cancer research institutes, with an outstanding record of achievement dating back more than 100 years. Further information about working at the ICR can be foundhere . At the Institute of Cancer Research, we champion diversity as we believe it fuels innovation and drives impactful research. We welcome applicants from all walks of life, valuing diverse perspectives that enrich our work. Don't let a checklist of qualifications hold you back - if you're passionate about the role, we want to hear from you. Your unique experiences and backgrounds contribute to the richness of our team. We are committed to being an equal opportunity for all, regardless of ethnicity, gender, age, sexual orientation, disability, or any other dimension of diversity. Join us in creating an inclusive environment where everyone's voice is heard and valued.
Jun 30, 2025
Full time
External Advertising End Date Advertising End Date: Salary: £47,400 per year. This role is eligible for ICR Sponsorship. Support will be provided for costs associated with Visa application. If you are considering relocating to the UK. Duration of Contract: Fixed Term for 12 months Hours per week: 35 hours per week (Full Time) Location: Sutton Closing Date: 31 July 2025 Please note: We reserve the right to close this vacancy early if we receive a high volume of applications. We recommend submitting your application as soon as possible to ensure it is considered. Under the guidance of Dr Alec Paschalis, we are seeking to recruit a Postdoctoral Training Fellow to contribute to cutting-edge research aimed at understanding how advanced cancers adapt and develop resistance to treatment. The purpose of this role is to drive the development of novel therapeutic strategies and improve existing standards of care. The successful candidate will play a key role in leading and executing laboratory-based research projects, including conducting functional assays on cancer models, analysing molecular data, supporting manuscript and grant preparation, and contributing to the overall management and collaborative activities of the Translational and Experimental Medicine Group. About you The successful candidate must have: BSc in biological sciences (first honours), PhD in biological sciences (submitted). Experience in molecular biology cancer research Practical skills for cell culture and molecular biology techniques. Problem-solving skills, ability to organise and prioritise work to meet deadlines. Work independently and as part of a team. Enthusiasm to work in an interdisciplinary environment towards the goal of developing improves cancer therapies. Candidates who are nearing completion of their PhD may apply, but confirmation on awarded PhD is required within 6 months of employment. The ICR has a workforce agreement stating that Postdoctoral Training Fellows can only be employed for up to 7 years as PDTF at the ICR, providing total postdoctoral experience (including previous employment at this level elsewhere) does not exceed 7 years. For general information on Postdocs atThe ICR, more informationcan be foundhere . Department/Directorate Information : The Translational and Experimental Medicine Group Clinical Studies Division Dr Alec Paschalis is a Clinician Scientist and Leader of the Translational and Experimental Medicine Group. His research team is focused on identifying therapeutic vulnerabilities in advanced cancers to drive the development of novel biology driven 'Proof of Concept' and 'Proof of Mechanism' clinical studies and improve the outcomes for patients with cancer. This new team will consist of basic and clinical scientists and will be embedded in a vibrant world-class research environment. What we offer A dynamic and supportive research environment Access to state-of-the-art facilities and professional development opportunities Collaboration with leading researchers in the field Competitive salary and pension We encourage all applicants to access the job pack attached for more detailed information regarding this role. For an informal discussion regarding the role, please contact Dr Alec Paschalis via About The Institute of Cancer Research Why work for us? As a member of staff, you'll have exclusive access to a range ofstaff benefits . The ICR is committed to supporting overseas applicants applying for roles,please click here to find out further information. The Institute of Cancer Research, London, is one of the world's most influential cancer research institutes, with an outstanding record of achievement dating back more than 100 years. Further information about working at the ICR can be foundhere . At the Institute of Cancer Research, we champion diversity as we believe it fuels innovation and drives impactful research. We welcome applicants from all walks of life, valuing diverse perspectives that enrich our work. Don't let a checklist of qualifications hold you back - if you're passionate about the role, we want to hear from you. Your unique experiences and backgrounds contribute to the richness of our team. We are committed to being an equal opportunity for all, regardless of ethnicity, gender, age, sexual orientation, disability, or any other dimension of diversity. Join us in creating an inclusive environment where everyone's voice is heard and valued.
The International Society for Bayesian Analysis
Cambridge, Cambridgeshire
Postdoc in Bayesian machine learning, AstraZeneca, Cambridge, UK Mar 29, 2018 PREDICTING DRUG TOXICITY WITH BAYESIAN MACHINE LEARNING MODELS We're currently looking for talented scientists to join our innovative academic-style Postdoc. From our centre in Cambridge, UK you'll be in a global pharmaceutical environment, contributing to live projects right from the start. You'll take part in a comprehensive training programme, including a focus on drug discovery and development, given access to our existing Postdoctoral research, and encouraged to pursue your own independent research. It's a newly expanding programme spanning a range of therapeutic areas across a wide range of disciplines. What's more, you'll have the support of a leading academic advisor, who'll provide you with the guidance and knowledge you need to develop your career. You will be part of the Quantitative Biology group and develop comprehensive Bayesian machine learning models for predicting drug toxicity in liver, heart, and other organs. This includes predicting the mechanism as well as the probability of toxicity by incorporating scientific knowledge into the prediction problem, such as known causal relationships and known toxicity mechanisms. Bayesian models will be used to account for uncertainty in the inputs and propagate this uncertainty into the predictions. In addition, you will promote the use of Bayesian methods across safety pharmacology and biology more generally. You are also expected to present your findings at key conferences and in leading publications This project is in collaboration with Prof. Andrew Gelman at Columbia University, and Dr Stanley Lazic at AstraZeneca. Education and Experience Required: - PhD in Statistics, Computer Science, Data Science, or similar - Excellent knowledge of either R or Python (ideally both) - Knowledge of Bayesian statistics - Knowledge of modern Bayesian software such as Stan and PyMC3 - Knowledge of (or an interest in) life sciences This is a 3 year programme. 2 years will be a Fixed Term Contract, with a 1 year extension which will be merit based. The role will be based at Cambridge, UK with a competitive salary on offer. To apply for this position, please follow the link below:
Jun 29, 2025
Full time
Postdoc in Bayesian machine learning, AstraZeneca, Cambridge, UK Mar 29, 2018 PREDICTING DRUG TOXICITY WITH BAYESIAN MACHINE LEARNING MODELS We're currently looking for talented scientists to join our innovative academic-style Postdoc. From our centre in Cambridge, UK you'll be in a global pharmaceutical environment, contributing to live projects right from the start. You'll take part in a comprehensive training programme, including a focus on drug discovery and development, given access to our existing Postdoctoral research, and encouraged to pursue your own independent research. It's a newly expanding programme spanning a range of therapeutic areas across a wide range of disciplines. What's more, you'll have the support of a leading academic advisor, who'll provide you with the guidance and knowledge you need to develop your career. You will be part of the Quantitative Biology group and develop comprehensive Bayesian machine learning models for predicting drug toxicity in liver, heart, and other organs. This includes predicting the mechanism as well as the probability of toxicity by incorporating scientific knowledge into the prediction problem, such as known causal relationships and known toxicity mechanisms. Bayesian models will be used to account for uncertainty in the inputs and propagate this uncertainty into the predictions. In addition, you will promote the use of Bayesian methods across safety pharmacology and biology more generally. You are also expected to present your findings at key conferences and in leading publications This project is in collaboration with Prof. Andrew Gelman at Columbia University, and Dr Stanley Lazic at AstraZeneca. Education and Experience Required: - PhD in Statistics, Computer Science, Data Science, or similar - Excellent knowledge of either R or Python (ideally both) - Knowledge of Bayesian statistics - Knowledge of modern Bayesian software such as Stan and PyMC3 - Knowledge of (or an interest in) life sciences This is a 3 year programme. 2 years will be a Fixed Term Contract, with a 1 year extension which will be merit based. The role will be based at Cambridge, UK with a competitive salary on offer. To apply for this position, please follow the link below:
Jobs in Structural Biology and Related Fields 2 x PDRA positions in Siebold lab, University of Oxford University of Oxford, Oxford, United Kingdom Postdoctoral Research Scientist in Membrane Protein Structural Biology and GPCR signalling The Division of Structural Biology, Building for Genomic Medicine Roosevelt Drive, Oxford, OX3 7BN We are seeking a highly motivated Postdoctoral Research Scientist to join Professor Christian Siebold's lab at the University of Oxford. This appointment supports our contribution to an Imperial led Wellcome Trust Discovery Grant titled "Allosteric modulation of class B1 GPCRs via cholesterol binding sites". This award brings together a multidisciplinary consortium-spanning structural biology, computational modelling, and invivo physiology-to dissect cholesterol mediated modulation of key receptors like Glucagon receptor and GLP 1R, with direct relevance to metabolic disease therapeutics. The Siebold group focuses on the structural and mechanistic analysis of membrane protein complexes involved in cell-to-cell communication and signal transduction. Within this role, you will work at the interface of structural biology and cell biology, applying techniques such as mammalian protein expression, protein purification, and single-particle cryo-electron microscopy (cryo-EM) to investigate G protein coupled receptor complexes. You will be expected to take an active role in experimental design, data interpretation, and dissemination of results through high-quality publications and presentations. You will also contribute to the preparation of research reports and funding proposals, and may assist in coordinating aspects of this complex, multi-institutional research programme. With a current PhD/DPhil (or close to completion) in chemistry, biology, or a related field, you will have demonstrable research experience in structural biology of membrane proteins using single particle cryo-EM, in particular data collection, processing and structure solution. Similar research experience in mammalian cell culture expression and production of membrane proteins for structural studies is also desirable. This post offers an exciting opportunity to work in a vibrant research environment with access to state-of-the-art facilities and strong national and international collaborations. Why Siebold Lab & this project? Work within a leading structural biology team focusing on membrane protein complexes, signalling and receptor pharmacology. Benefit from access to top-tier cryo-EM facilities and vibrant collaborations across Oxford, the UK Diamond Light Source synchrotron, and Imperial College London. Target fundamental mechanisms with clear translational relevance to diabetes, obesity, and metabolic disorders. Applications for this vacancy should be made online, and you will need to upload a supporting statement and CV. Your supporting statement must explain how you meet each of the selection criteria for the post using examples of your skills and experience. Please restrict your documentation to your CV and supporting statement only. Any other documents will be requested at a later date. This position is offered full time on a fixed term contract for 3 years and is externally funded by the Wellcome. Only applications received before 12 midday on 17 July 2025 will be considered. Please quote 179875 on all correspondence. Contact Person : Bogdan Tiritelnicu Vacancy ID : 179875 Contact Phone : Closing Date & Time : 17-Jul-:00 Pay Scale : RESEARCH GRADE 7 Contact Email : Salary (£) : Research Grade 7: £38,674 - £41,997 p.a. This is inclusive of a pensionable Oxford University Weighting of £1,500 per year. Postdoctoral Research Scientist in Membrane Protein Structural Biology and Protein Acylation The Division of Structural Biology, Building for Genomic Medicine, Roosevelt Drive, Oxford, OX3 7BN We are seeking to appoint a highly motivated Postdoctoral Research Scientist to join the laboratory of Professor Christian Siebold at the University of Oxford. You will contribute to the BBSRC-funded Strategic Longer and Larger (sLoLa) research programme entitled "An integrated analysis of S-acylation dynamics and its importance in cell physiology." This collaborative, multidisciplinary project is led by the University of Strathclyde and involves leading institutions across the UK.The Siebold group focuses on the structural and mechanistic analysis of membrane protein complexes involved in cell-to-cell communication and signal transduction. You will work at the interface of structural biology and cell biology, applying techniques such as mammalian protein expression, protein purification, and single-particle cryo-electron microscopy (cryo-EM) to investigate membrane protein complexes involved in lipid transfer and modification.You will be expected to take an active role in experimental design, data interpretation, and dissemination of results through high-quality publications and presentations. You will also contribute to the preparation of research reports and funding proposals and may assist in coordinating aspects of this complex, multi-institutional research programme.With a current PhD/DPhil (or close to completion) in chemistry, biology, or a related field, you will have demonstrable research experience in structural biology of membrane proteins using single particle cryo-EM, in particular data collection, processing and structure solution. Similar research experience in mammalian cell culture expression and production of membrane proteins for structural studies is also desirable.This post offers an exciting opportunity to work in a vibrant research environment with access to state-of-the-art facilities and strong national and international collaborations.Why Siebold Lab & this project? Work within a leading structural biology team focusing on membrane protein complexes, signalling and receptor pharmacology. Benefit from access to top-tier cryo-EM facilities and vibrant collaborations across the UK, including the UK Diamond Light Source synchrotron, and Imperial College London. Target fundamental mechanisms with clear translational relevance to cancer, heart diseases and other developmental and neurological diseases. Applications for this vacancy should be made online and you will need to upload a supporting statement and CV. Your supporting statement must explain how you meet each of the selection criteria for the post using examples of your skills and experience. Please restrict your documentation to your CV and supporting statement only. Any other documents will be requested at a later date.This position is offered full time on a fixed term contract for 3 years and is externally funded by BBSRC.Only applications received before 12 midday on 17 July 2025 will be considered. Please quote 179874 on all correspondence. Contact Person : Bogdan Tiritelnicu Vacancy ID : 179874 Contact Phone : Closing Date & Time : 17-Jul-:00 Pay Scale : RESEARCH GRADE 7 Contact Email : Salary (£) : Research Grade 7: £38,674 - £41,997 p.a. This is inclusive of a pensionable Oxford University Weighting of £1,500 per year.
Jun 27, 2025
Full time
Jobs in Structural Biology and Related Fields 2 x PDRA positions in Siebold lab, University of Oxford University of Oxford, Oxford, United Kingdom Postdoctoral Research Scientist in Membrane Protein Structural Biology and GPCR signalling The Division of Structural Biology, Building for Genomic Medicine Roosevelt Drive, Oxford, OX3 7BN We are seeking a highly motivated Postdoctoral Research Scientist to join Professor Christian Siebold's lab at the University of Oxford. This appointment supports our contribution to an Imperial led Wellcome Trust Discovery Grant titled "Allosteric modulation of class B1 GPCRs via cholesterol binding sites". This award brings together a multidisciplinary consortium-spanning structural biology, computational modelling, and invivo physiology-to dissect cholesterol mediated modulation of key receptors like Glucagon receptor and GLP 1R, with direct relevance to metabolic disease therapeutics. The Siebold group focuses on the structural and mechanistic analysis of membrane protein complexes involved in cell-to-cell communication and signal transduction. Within this role, you will work at the interface of structural biology and cell biology, applying techniques such as mammalian protein expression, protein purification, and single-particle cryo-electron microscopy (cryo-EM) to investigate G protein coupled receptor complexes. You will be expected to take an active role in experimental design, data interpretation, and dissemination of results through high-quality publications and presentations. You will also contribute to the preparation of research reports and funding proposals, and may assist in coordinating aspects of this complex, multi-institutional research programme. With a current PhD/DPhil (or close to completion) in chemistry, biology, or a related field, you will have demonstrable research experience in structural biology of membrane proteins using single particle cryo-EM, in particular data collection, processing and structure solution. Similar research experience in mammalian cell culture expression and production of membrane proteins for structural studies is also desirable. This post offers an exciting opportunity to work in a vibrant research environment with access to state-of-the-art facilities and strong national and international collaborations. Why Siebold Lab & this project? Work within a leading structural biology team focusing on membrane protein complexes, signalling and receptor pharmacology. Benefit from access to top-tier cryo-EM facilities and vibrant collaborations across Oxford, the UK Diamond Light Source synchrotron, and Imperial College London. Target fundamental mechanisms with clear translational relevance to diabetes, obesity, and metabolic disorders. Applications for this vacancy should be made online, and you will need to upload a supporting statement and CV. Your supporting statement must explain how you meet each of the selection criteria for the post using examples of your skills and experience. Please restrict your documentation to your CV and supporting statement only. Any other documents will be requested at a later date. This position is offered full time on a fixed term contract for 3 years and is externally funded by the Wellcome. Only applications received before 12 midday on 17 July 2025 will be considered. Please quote 179875 on all correspondence. Contact Person : Bogdan Tiritelnicu Vacancy ID : 179875 Contact Phone : Closing Date & Time : 17-Jul-:00 Pay Scale : RESEARCH GRADE 7 Contact Email : Salary (£) : Research Grade 7: £38,674 - £41,997 p.a. This is inclusive of a pensionable Oxford University Weighting of £1,500 per year. Postdoctoral Research Scientist in Membrane Protein Structural Biology and Protein Acylation The Division of Structural Biology, Building for Genomic Medicine, Roosevelt Drive, Oxford, OX3 7BN We are seeking to appoint a highly motivated Postdoctoral Research Scientist to join the laboratory of Professor Christian Siebold at the University of Oxford. You will contribute to the BBSRC-funded Strategic Longer and Larger (sLoLa) research programme entitled "An integrated analysis of S-acylation dynamics and its importance in cell physiology." This collaborative, multidisciplinary project is led by the University of Strathclyde and involves leading institutions across the UK.The Siebold group focuses on the structural and mechanistic analysis of membrane protein complexes involved in cell-to-cell communication and signal transduction. You will work at the interface of structural biology and cell biology, applying techniques such as mammalian protein expression, protein purification, and single-particle cryo-electron microscopy (cryo-EM) to investigate membrane protein complexes involved in lipid transfer and modification.You will be expected to take an active role in experimental design, data interpretation, and dissemination of results through high-quality publications and presentations. You will also contribute to the preparation of research reports and funding proposals and may assist in coordinating aspects of this complex, multi-institutional research programme.With a current PhD/DPhil (or close to completion) in chemistry, biology, or a related field, you will have demonstrable research experience in structural biology of membrane proteins using single particle cryo-EM, in particular data collection, processing and structure solution. Similar research experience in mammalian cell culture expression and production of membrane proteins for structural studies is also desirable.This post offers an exciting opportunity to work in a vibrant research environment with access to state-of-the-art facilities and strong national and international collaborations.Why Siebold Lab & this project? Work within a leading structural biology team focusing on membrane protein complexes, signalling and receptor pharmacology. Benefit from access to top-tier cryo-EM facilities and vibrant collaborations across the UK, including the UK Diamond Light Source synchrotron, and Imperial College London. Target fundamental mechanisms with clear translational relevance to cancer, heart diseases and other developmental and neurological diseases. Applications for this vacancy should be made online and you will need to upload a supporting statement and CV. Your supporting statement must explain how you meet each of the selection criteria for the post using examples of your skills and experience. Please restrict your documentation to your CV and supporting statement only. Any other documents will be requested at a later date.This position is offered full time on a fixed term contract for 3 years and is externally funded by BBSRC.Only applications received before 12 midday on 17 July 2025 will be considered. Please quote 179874 on all correspondence. Contact Person : Bogdan Tiritelnicu Vacancy ID : 179874 Contact Phone : Closing Date & Time : 17-Jul-:00 Pay Scale : RESEARCH GRADE 7 Contact Email : Salary (£) : Research Grade 7: £38,674 - £41,997 p.a. This is inclusive of a pensionable Oxford University Weighting of £1,500 per year.
Postdoctoral Research Scientist in Metagenomics Job Title Postdoctoral Research Scientist in Metagenomics Post Number Closing Date 8 Jul 2025 Grade SC6 Starting Salary Salary: £36,720-£42,000 Funding End Date 16 Jul 2026 Hours per week 37 Project Title Microbial drivers of atmospheric methane emission Expected/Ideal Start Date 01 Aug 2025 Months Duration 9 Interview Date 14 Jul 2025 Job Description Main Purpose of the Job Applications are invited for a Research Scientist to join the Laboratory of Dr Hildebrand at the Quadram Institute Bioscience (QIB), Norwich, UK. This post is part of a NERC project revealing the role of ammonia oxidising archaea in methane oxidation in the environment. The postholder will work with sequencing data derived from cultivated and natural soil microbiomes, to understand the role of prokaryotes (Archaea and Bacteria) in mitigating greenhouse gas emissions. Specifically, pipelines for SIP-enriched metagenomic sequencing and functional-targeted amplicon sequencing data will be developed (based on existing work in the group) and applied to interpret experiments conducted in the laboratory of collaborators. The project holder will use metagenomics (similar to doi:10.1038/s-6, 10 15314, 10.1186/s5-1) to profile both taxonomic and functional compositions of for SIP-enriched metagenomic sequencing and functional-targeted amplicon sequencing and metatranscriptomics data. The bioinformatic tools will be developed to analyse and correct these data types, the statistical workflows established to interpret and understand how ammonia oxidising microorganisms respond to methane in soil. Long-term, this work will contribute to reducing the impact of climate changes by manipulating existing microbial communities, and understanding how healthy soil microbiomes are established and maintained. Key Relationships The post holder will work closely with other group members, the line manager Dr Falk Hildebrand and collaborators Profs Laura Lehtovirta-Morley and Fred Warren. The applicant is expected to help in the supervision of junior group members and to represent the group at trainings. The applicant will have direct access to established PacBio/ONT, Hi-C and single cell sequencing facilities, as well as one of UK's largest HPC cluster at the NRP. Main Activities & Responsibilities Percentage Process and analyse soil metagenomes/metatranscriptomes 30 Use machine learning/statistics to characterize & predict community states 25 Develop new bioinformatic tools to process specialized metagenomic sequence data 25 Support group with tasks such as outreach, student supervision, writing grants 15 As agreed with the line manager, any other duties commensurate with the nature of the post, for example, contributing to the work of Institute committees 5 Person Profile Education & Qualifications Requirement Importance PhD in Bioinformatics, Soil science, Ecology or Microbiology, or equivalent experience Essential Specialist Knowledge & Skills Requirement Importance Programming skills (e.g. C++, Perl, python or R) Essential Understanding of microbiomes, preferably environmental and soil microbiomes Essential Ability to troubleshoot and solve problems Essential Initiative and a desire to learn, to innovate, and to move out of their comfort zone Essential Ability to work independently on research projects Desirable Requirement Importance Familiarity with sequencing related, metagenomics, or metatranscriptomics, or soil microbial bioinformatics Essential Bioinformatics experience Essential Proven track-record of research output at the appropriate level Essential Experience grant writing or supervising lab members Desirable Interpersonal & Communication Skills Requirement Importance Excellent communication skills, both written and oral Essential Promotes and strives for continuous improvement Essential Excellent interpersonal skills, with the ability to work alone and as part of a team Essential Reliable and conscientious Essential Additional Requirements Requirement Importance Attention to detail Essential Promotes equality and values diversity Essential Willingness to embrace the expected values and behaviours of all staff at the Institute, ensuring it is a great place to work Essential Able to present a positive image of self and the Institute, promoting both the international reputation and public engagement aims of the Institute Essential Willingness to work outside standard working hours when required Essential Willingness to undertake any necessary training for the role Essential Who We Are Quadram Institute Bioscience The Quadram Institute is at the forefront of a new interface between food science, gut biology and health, developing solutions to worldwide challenges in food-related disease and human health. We are engaged in fundamental and translational food and health research, alongside clinical studies, endoscopy and industry, working together to become a leading international hub for food and health research, combining scientific excellence and clinical expertise, delivering impacts on patient care and accelerating innovation. The Quadram Institute is a diverse and multicultural scientific community. We thrive on our international and European links, appointing staff from across the world. Any candidate who would like further information on current or anticipated immigration requirements can contact the HR Team on (0) or . The Hildebrand group uses meta omics to research the diversity, community interactions, and evolution of microbes in communities. Currently the group has projects in both human associated and environmental (soil, lakes) microbiomes, for which custom bioinformatic solutions are developed in-house to enable a wholistic microbiome exploration. We advocate strain-resolved metagenomics and develop the numerical solutions to work with MAGs intra-specific phylogenies. For representative publications relevant to the post please see (doi: 10.1016/j.chom.2023.05.024 , 10.1101/2024.09.09. , 10.1016/j.chom.2021.05.008) and for group information. The Quadram Institute is based on the Norwich Research Park, which is one of the largest single-site concentrations of research in food, genomics, and health in Europe. The Park hosts 4 BBSRC Institutes (including Earlham), 17,000 students, 3,000 full-time researchers and clinicians, and over 115 companies. The outstanding reputation of our researchers is internationally recognised, with 10 of the Park's scientists in the top 1% of the "most highly cited" in the world, including Dr Falk Hildebrand. Research Scientist (Soil metagenomics) Applications are invited for a Research Scientist to join the Laboratory of Dr Hildebrand at Quadram Institute, Norwich, UK. Background: This post is part of the NERC project "Identifying novel microbial drivers to mitigate atmospheric methane emission". Methane is a powerful greenhouse gas, and we aim to reveal the role of ammonia oxidizing Archaea in methane oxidation in the environment. The project will determine how methane affects soil microbial communities, and how specific soil microorganisms respond to methane and metabolise it. The postholder will work with sequencing data derived from cultivated and natural soil microbiomes, to understand the roleof prokaryotes (Archaea and Bacteria) in mitigating greenhouse gas emissions. The role: The project holder will use metagenomics (similar to doi:10.1038/s-6, 10 15314, 10.1186/s5-1) to profile both taxonomic and functional compositions of for SIP-enriched metagenomic and metatranscriptomic sequencing and functional-targeted amplicon sequencing data, interpreting experiments conducted in the laboratory of Prof Laura Lehtovirta-Morley. The bioinformatic tools will be developed to analyse and correct these data types, the statistical workflows established to interpret and understand how microorganisms respond to methane in both pristine and laboratory-based soil communities, building on tools available in the Hildebrand group . Long-term, this work will advance our understanding of biogeochemical cycling, contribute to reducing the impact of climate change by manipulating existing microbial communities, and understanding how healthy soil microbiomes are established, and maintained. The environment: The Hildebrand group uses metagenomics to research the diversity, community interactions, and evolution of microbes in communities using custom software solutions. The Lehtovirta-Morley group explores environmental microbiomes and biogeochemical cycling using both cultivation-independent and cultivation-dependent experiments. Both groups collaborate closely on microbial archaeal research in soils. The research is situated at the Norwich Research Park (NRP) UK, that encompasses the University of East Anglia, 4 BBSRC Institute, > 15 companies, 3,000 researchers and clinicians, 17,000 students. Norwich ranked in the top 10 for UK cities with a beautiful, historical town centre and an active gastropub & coffee aficionado scene. The applicant is expected to help in the supervision of junior group members and to represent the group at trainings. The applicant will have direct access to established PacBio/ONT, Hi-C and single cell sequencing facilities, as well as one of UK's largest HPC cluster at the NRP. The ideal candidate: The applicant needs to hold a PhD (or equivalent) in biology, bioinformatics . click apply for full job details
Jun 18, 2025
Full time
Postdoctoral Research Scientist in Metagenomics Job Title Postdoctoral Research Scientist in Metagenomics Post Number Closing Date 8 Jul 2025 Grade SC6 Starting Salary Salary: £36,720-£42,000 Funding End Date 16 Jul 2026 Hours per week 37 Project Title Microbial drivers of atmospheric methane emission Expected/Ideal Start Date 01 Aug 2025 Months Duration 9 Interview Date 14 Jul 2025 Job Description Main Purpose of the Job Applications are invited for a Research Scientist to join the Laboratory of Dr Hildebrand at the Quadram Institute Bioscience (QIB), Norwich, UK. This post is part of a NERC project revealing the role of ammonia oxidising archaea in methane oxidation in the environment. The postholder will work with sequencing data derived from cultivated and natural soil microbiomes, to understand the role of prokaryotes (Archaea and Bacteria) in mitigating greenhouse gas emissions. Specifically, pipelines for SIP-enriched metagenomic sequencing and functional-targeted amplicon sequencing data will be developed (based on existing work in the group) and applied to interpret experiments conducted in the laboratory of collaborators. The project holder will use metagenomics (similar to doi:10.1038/s-6, 10 15314, 10.1186/s5-1) to profile both taxonomic and functional compositions of for SIP-enriched metagenomic sequencing and functional-targeted amplicon sequencing and metatranscriptomics data. The bioinformatic tools will be developed to analyse and correct these data types, the statistical workflows established to interpret and understand how ammonia oxidising microorganisms respond to methane in soil. Long-term, this work will contribute to reducing the impact of climate changes by manipulating existing microbial communities, and understanding how healthy soil microbiomes are established and maintained. Key Relationships The post holder will work closely with other group members, the line manager Dr Falk Hildebrand and collaborators Profs Laura Lehtovirta-Morley and Fred Warren. The applicant is expected to help in the supervision of junior group members and to represent the group at trainings. The applicant will have direct access to established PacBio/ONT, Hi-C and single cell sequencing facilities, as well as one of UK's largest HPC cluster at the NRP. Main Activities & Responsibilities Percentage Process and analyse soil metagenomes/metatranscriptomes 30 Use machine learning/statistics to characterize & predict community states 25 Develop new bioinformatic tools to process specialized metagenomic sequence data 25 Support group with tasks such as outreach, student supervision, writing grants 15 As agreed with the line manager, any other duties commensurate with the nature of the post, for example, contributing to the work of Institute committees 5 Person Profile Education & Qualifications Requirement Importance PhD in Bioinformatics, Soil science, Ecology or Microbiology, or equivalent experience Essential Specialist Knowledge & Skills Requirement Importance Programming skills (e.g. C++, Perl, python or R) Essential Understanding of microbiomes, preferably environmental and soil microbiomes Essential Ability to troubleshoot and solve problems Essential Initiative and a desire to learn, to innovate, and to move out of their comfort zone Essential Ability to work independently on research projects Desirable Requirement Importance Familiarity with sequencing related, metagenomics, or metatranscriptomics, or soil microbial bioinformatics Essential Bioinformatics experience Essential Proven track-record of research output at the appropriate level Essential Experience grant writing or supervising lab members Desirable Interpersonal & Communication Skills Requirement Importance Excellent communication skills, both written and oral Essential Promotes and strives for continuous improvement Essential Excellent interpersonal skills, with the ability to work alone and as part of a team Essential Reliable and conscientious Essential Additional Requirements Requirement Importance Attention to detail Essential Promotes equality and values diversity Essential Willingness to embrace the expected values and behaviours of all staff at the Institute, ensuring it is a great place to work Essential Able to present a positive image of self and the Institute, promoting both the international reputation and public engagement aims of the Institute Essential Willingness to work outside standard working hours when required Essential Willingness to undertake any necessary training for the role Essential Who We Are Quadram Institute Bioscience The Quadram Institute is at the forefront of a new interface between food science, gut biology and health, developing solutions to worldwide challenges in food-related disease and human health. We are engaged in fundamental and translational food and health research, alongside clinical studies, endoscopy and industry, working together to become a leading international hub for food and health research, combining scientific excellence and clinical expertise, delivering impacts on patient care and accelerating innovation. The Quadram Institute is a diverse and multicultural scientific community. We thrive on our international and European links, appointing staff from across the world. Any candidate who would like further information on current or anticipated immigration requirements can contact the HR Team on (0) or . The Hildebrand group uses meta omics to research the diversity, community interactions, and evolution of microbes in communities. Currently the group has projects in both human associated and environmental (soil, lakes) microbiomes, for which custom bioinformatic solutions are developed in-house to enable a wholistic microbiome exploration. We advocate strain-resolved metagenomics and develop the numerical solutions to work with MAGs intra-specific phylogenies. For representative publications relevant to the post please see (doi: 10.1016/j.chom.2023.05.024 , 10.1101/2024.09.09. , 10.1016/j.chom.2021.05.008) and for group information. The Quadram Institute is based on the Norwich Research Park, which is one of the largest single-site concentrations of research in food, genomics, and health in Europe. The Park hosts 4 BBSRC Institutes (including Earlham), 17,000 students, 3,000 full-time researchers and clinicians, and over 115 companies. The outstanding reputation of our researchers is internationally recognised, with 10 of the Park's scientists in the top 1% of the "most highly cited" in the world, including Dr Falk Hildebrand. Research Scientist (Soil metagenomics) Applications are invited for a Research Scientist to join the Laboratory of Dr Hildebrand at Quadram Institute, Norwich, UK. Background: This post is part of the NERC project "Identifying novel microbial drivers to mitigate atmospheric methane emission". Methane is a powerful greenhouse gas, and we aim to reveal the role of ammonia oxidizing Archaea in methane oxidation in the environment. The project will determine how methane affects soil microbial communities, and how specific soil microorganisms respond to methane and metabolise it. The postholder will work with sequencing data derived from cultivated and natural soil microbiomes, to understand the roleof prokaryotes (Archaea and Bacteria) in mitigating greenhouse gas emissions. The role: The project holder will use metagenomics (similar to doi:10.1038/s-6, 10 15314, 10.1186/s5-1) to profile both taxonomic and functional compositions of for SIP-enriched metagenomic and metatranscriptomic sequencing and functional-targeted amplicon sequencing data, interpreting experiments conducted in the laboratory of Prof Laura Lehtovirta-Morley. The bioinformatic tools will be developed to analyse and correct these data types, the statistical workflows established to interpret and understand how microorganisms respond to methane in both pristine and laboratory-based soil communities, building on tools available in the Hildebrand group . Long-term, this work will advance our understanding of biogeochemical cycling, contribute to reducing the impact of climate change by manipulating existing microbial communities, and understanding how healthy soil microbiomes are established, and maintained. The environment: The Hildebrand group uses metagenomics to research the diversity, community interactions, and evolution of microbes in communities using custom software solutions. The Lehtovirta-Morley group explores environmental microbiomes and biogeochemical cycling using both cultivation-independent and cultivation-dependent experiments. Both groups collaborate closely on microbial archaeal research in soils. The research is situated at the Norwich Research Park (NRP) UK, that encompasses the University of East Anglia, 4 BBSRC Institute, > 15 companies, 3,000 researchers and clinicians, 17,000 students. Norwich ranked in the top 10 for UK cities with a beautiful, historical town centre and an active gastropub & coffee aficionado scene. The applicant is expected to help in the supervision of junior group members and to represent the group at trainings. The applicant will have direct access to established PacBio/ONT, Hi-C and single cell sequencing facilities, as well as one of UK's largest HPC cluster at the NRP. The ideal candidate: The applicant needs to hold a PhD (or equivalent) in biology, bioinformatics . click apply for full job details
Our client is a leading provider of Next Generation Sequencing (NGS) solutions to support the ongoing development of genetic-based medicine. An opportunity has now become available for an experienced NGS scientist to join the company and support with the product development projects within their NGS platforms. The role: The successful applicant will be responsible for: Acting as technical lead on R&D projects for the improvement and development of NGS assays Oversee project delivery, outlining practical resources, delivery criteria and milestones Deliver project results and present data through internal and external meetings Suitable applicants: Research and/or Postdoctoral experience focussed on NGS development, including troubleshooting and validation, for commercial applications. Proven experience performing R&D projects, with clear evidence of managing timelines and deliverables Educated to PhD in Genomics/Molecular Biology (or equivalent experience) Deep knowledge of Next Generation Sequencing Good commercial acumen with understanding of product pipelines Suitable candidates can expect a permanent position with a competitive salary commensurate to experience (plus benefits) I'm interested in this job Please use the form provided to get in touch with us and we will respond as soon as possible. Compulsory fields are in bold . I'm interested in this job Please use the form provided to get in touch with us and we will respond as soon as possible. Compulsory fields are in bold . Name Email address Telephone Message Upload C.V. Your file must be in one of the following formats: pdf , doc , docx , rtf , txt and no larger than 2MB . Recaptcha requires verification. I'm not a robot reCAPTCHA Privacy - Terms
Jun 17, 2025
Full time
Our client is a leading provider of Next Generation Sequencing (NGS) solutions to support the ongoing development of genetic-based medicine. An opportunity has now become available for an experienced NGS scientist to join the company and support with the product development projects within their NGS platforms. The role: The successful applicant will be responsible for: Acting as technical lead on R&D projects for the improvement and development of NGS assays Oversee project delivery, outlining practical resources, delivery criteria and milestones Deliver project results and present data through internal and external meetings Suitable applicants: Research and/or Postdoctoral experience focussed on NGS development, including troubleshooting and validation, for commercial applications. Proven experience performing R&D projects, with clear evidence of managing timelines and deliverables Educated to PhD in Genomics/Molecular Biology (or equivalent experience) Deep knowledge of Next Generation Sequencing Good commercial acumen with understanding of product pipelines Suitable candidates can expect a permanent position with a competitive salary commensurate to experience (plus benefits) I'm interested in this job Please use the form provided to get in touch with us and we will respond as soon as possible. Compulsory fields are in bold . I'm interested in this job Please use the form provided to get in touch with us and we will respond as soon as possible. Compulsory fields are in bold . Name Email address Telephone Message Upload C.V. Your file must be in one of the following formats: pdf , doc , docx , rtf , txt and no larger than 2MB . Recaptcha requires verification. I'm not a robot reCAPTCHA Privacy - Terms
Contract - Initially a 2 year fixed term contract - onsite. Salary - £40,000 - £45,000 depending on experience. Our client are a scientifically passionate company who lead extensive collaborations and offer services to the Drug Discovery and Disease Research sectors. They collaborate with lead researchers and organisations to enhance the understanding of immunological, oncological, neurological and other disease areas. Based in Alderley Park, they are offering an exciting opportunity for an enthusiastic and hard-working individual to join their in vivo imaging team as a Senior Scientist. If you are looking to work on exciting translational in vivo imaging projects and want to further your career, then this could be the opportunity you have been waiting for. The Role This is a role for experienced Imaging Scientists who hold a PhD (or Master's) in a biologically focused discipline, with additional postdoctoral or industry experience. As a Senior Imaging Scientist, you will be responsible for: Designing and running mouse + rodent PET / in vivo imaging studies for a range of purposes including biodistribution, pharmacokinetics (PK) and cellular responses. Leading exciting projects relating to lipid nanoparticle based therapeutics. Delivery of high quality experimental data and presenting this to external partners. Oversee and manage projects spanning multiple organisations, from conception to completion. Innovating in the in vivo imaging space to bring new technologies or ways of applying the technology to projects. Adhering to regulations and guidelines for in vivo work, including Home-Office project licence. Labelling / radiolabelling of LNPs (optional) Skills and Experience Needed: Suitable applicants must have: A PhD or Master's - focused around biological imaging (essential) Significant experience of developing pre-clinical in vivo mouse and rodent models (essential) Hold a personal Home Office PIL ABC licence (essential) Must have significant experience in positron emission tomography (PET) imaging and data analysis + image reconstruction tools (essential) Proven experience of routine in vivo techniques such as tissue collection, blood sampling, dosing via common routes etc (essential) Experience in leading, or influencing complex scientific projects (essential) Strong experience in ex vivo techniques like immunohistochemistry (IHC), immunofluorescence staining, microscopy etc (essential) Good communication and problem-solving skills (essential) Suitable applicants could have: Experience working on complex projects spanning across multiple organisation types (CRO, biotech, medical research charity, academia, etc) (desired) Experience in other in vivo imaging techniques including SPECT, IVIS, MRI etc (nice to have) PMOD image analysis software experience (desired) Radioligand labelling experience (nice to have) Working on lipid nanoparticle (LNP) within formulation, dosing or translational studies (nice to have) Prior industry experience in an SME or pharmaceutical company (desired) The Package Being a leading collaborative drug discovery company, our client is offering the chance to be part of a growing organisation on a temporary basis, with a competitive salary and benefits package. To Apply If you would like to submit an application for this position, please contact Charlie Cox on , or send an email to I'm interested in this job Please use the form provided to get in touch with us and we will respond as soon as possible. Compulsory fields are in bold . I'm interested in this job Please use the form provided to get in touch with us and we will respond as soon as possible. Compulsory fields are in bold . Name Email address Telephone Message Upload C.V. Your file must be in one of the following formats: pdf , doc , docx , rtf , txt and no larger than 2MB . Recaptcha requires verification. I'm not a robot reCAPTCHA Privacy - Terms
Jun 17, 2025
Full time
Contract - Initially a 2 year fixed term contract - onsite. Salary - £40,000 - £45,000 depending on experience. Our client are a scientifically passionate company who lead extensive collaborations and offer services to the Drug Discovery and Disease Research sectors. They collaborate with lead researchers and organisations to enhance the understanding of immunological, oncological, neurological and other disease areas. Based in Alderley Park, they are offering an exciting opportunity for an enthusiastic and hard-working individual to join their in vivo imaging team as a Senior Scientist. If you are looking to work on exciting translational in vivo imaging projects and want to further your career, then this could be the opportunity you have been waiting for. The Role This is a role for experienced Imaging Scientists who hold a PhD (or Master's) in a biologically focused discipline, with additional postdoctoral or industry experience. As a Senior Imaging Scientist, you will be responsible for: Designing and running mouse + rodent PET / in vivo imaging studies for a range of purposes including biodistribution, pharmacokinetics (PK) and cellular responses. Leading exciting projects relating to lipid nanoparticle based therapeutics. Delivery of high quality experimental data and presenting this to external partners. Oversee and manage projects spanning multiple organisations, from conception to completion. Innovating in the in vivo imaging space to bring new technologies or ways of applying the technology to projects. Adhering to regulations and guidelines for in vivo work, including Home-Office project licence. Labelling / radiolabelling of LNPs (optional) Skills and Experience Needed: Suitable applicants must have: A PhD or Master's - focused around biological imaging (essential) Significant experience of developing pre-clinical in vivo mouse and rodent models (essential) Hold a personal Home Office PIL ABC licence (essential) Must have significant experience in positron emission tomography (PET) imaging and data analysis + image reconstruction tools (essential) Proven experience of routine in vivo techniques such as tissue collection, blood sampling, dosing via common routes etc (essential) Experience in leading, or influencing complex scientific projects (essential) Strong experience in ex vivo techniques like immunohistochemistry (IHC), immunofluorescence staining, microscopy etc (essential) Good communication and problem-solving skills (essential) Suitable applicants could have: Experience working on complex projects spanning across multiple organisation types (CRO, biotech, medical research charity, academia, etc) (desired) Experience in other in vivo imaging techniques including SPECT, IVIS, MRI etc (nice to have) PMOD image analysis software experience (desired) Radioligand labelling experience (nice to have) Working on lipid nanoparticle (LNP) within formulation, dosing or translational studies (nice to have) Prior industry experience in an SME or pharmaceutical company (desired) The Package Being a leading collaborative drug discovery company, our client is offering the chance to be part of a growing organisation on a temporary basis, with a competitive salary and benefits package. To Apply If you would like to submit an application for this position, please contact Charlie Cox on , or send an email to I'm interested in this job Please use the form provided to get in touch with us and we will respond as soon as possible. Compulsory fields are in bold . I'm interested in this job Please use the form provided to get in touch with us and we will respond as soon as possible. Compulsory fields are in bold . Name Email address Telephone Message Upload C.V. Your file must be in one of the following formats: pdf , doc , docx , rtf , txt and no larger than 2MB . Recaptcha requires verification. I'm not a robot reCAPTCHA Privacy - Terms
Postdoctoral Project Research Scientist (PPRS) About us The Francis Crick Institute is Europe's largest biomedical research institute under one roof. Our world-class scientists and staff collaborate on vital research to help prevent, diagnose and treat illnesses such as cancer, heart disease, infectious diseases and neurodegenerative conditions. The Crick is a place for collaboration, innovation and exploration across many disciplines. A space where the brightest minds can pursue big and bold ideas and discover answers to crucial scientific questions. We support them in a dynamic environment which fosters excellence with state-of-the-art infrastructure, cutting-edge facilities, and a creative and curious culture. We've removed traditional boundaries of departments, divisions and disciplines and instead have an open approach that supports every researcher. This gives us the freedom to collaborate and carry out high-quality, pioneering research. Creating a space for discovery without boundaries helps us to turn our science into benefits for human health and the economy. About the role The Miguel-Aliaga lab seek to understand how organs sense and react to their environment to maintain or change our physiology. To this end, they focus on the study of the intestinal tract; certain diets, microbes or internal states can cause it to grow or shrink. Current projects explore this plasticity across scales. Following previous work on the role that the shape of the gastrointestinal (GI) tract plays in health and disease in the fruit fly, we are now working on extending this work into analysis of human GI tract shape. We have adapted our methods to analyse GI tract shape in abdominal MRI scans and now wish to scale this up to a larger dataset. We have an approved project to work with the data of the UK Biobank - a large-scale biomedical database of volunteers from across the UK. This includes genetic data and whole-body MRI scans for 100,000 participants. We aim to investigate whether in humans, there is an underlying logic to GI tract shape and 3D organ arrangement which might vary in males and females, post-pregnancy and in disease such as Crohn's disease. We are looking for an ambitious and experienced image analyst for this computational post to develop AI-based image analysis methods to extract GI tract shape data from whole-body MRI scans. What you will be doing As a PPRS at the Crick, you will be: Developing image analysis tools for analysis of GI tract shape and volume from MRI scans Developing a neural network for the automation of segmentation of the GI tract from UK Biobank whole-body MRI scans Liaising with other lab members and collaborators to link analysis of GI tract shape features with other phenotype data and genetics in the UK Biobank Contributing to the preparation of scientific manuscripts, reports and presentations About you The essential criteria you will bring PhD in Developmental Biology, Cell Biology, Computational Biology or in the final stages of PhD submission Strong level of competence and experience of the use of deep learning for image analysis in large datasets, particularly image segmentation Strong level of competence in writing macros for ImageJ/FIJI and use of other languages such as R and Python for image analysis Experience of working with large 3D datasets such as MRI scans or microCT scans Experience of image segmentation Track record of writing papers as evidenced by publications or submitted manuscripts in refereed journals Evidence of data presentation at scientific meetings About Working at the Crick Our values Everyone who works at the Crick has a valuable role to play in advancing the Crick's mission and shaping our culture! We are bold. We make space for creative, dynamic and imaginative ideas and approaches. We're not afraid to do things differently. We are open. We're highly collaborative and interactive, and make sure our activities are visible to the outside world. We are collegial. We show respect for one another, work cooperatively and support the wider community. At the Francis Crick Institute, we believe that diversity and inclusion are essential to driving innovation and scientific discovery. We are committed to creating a workplace where everyone feels valued, respected, and empowered to succeed, regardless of their background, identity, or personal circumstances. We actively encourage applications from individuals of all genders, ethnicities, abilities, and experiences. We are a Disability Confident: Committed employer and you will be asked as part of the process if you wish to apply under the scheme. We will make reasonable adjustments if you need them. If you need assistance with applying (i.e., would like to apply by phone or post) please email: Please note that interviews for this role will take place from 02/07/25.
Jun 13, 2025
Full time
Postdoctoral Project Research Scientist (PPRS) About us The Francis Crick Institute is Europe's largest biomedical research institute under one roof. Our world-class scientists and staff collaborate on vital research to help prevent, diagnose and treat illnesses such as cancer, heart disease, infectious diseases and neurodegenerative conditions. The Crick is a place for collaboration, innovation and exploration across many disciplines. A space where the brightest minds can pursue big and bold ideas and discover answers to crucial scientific questions. We support them in a dynamic environment which fosters excellence with state-of-the-art infrastructure, cutting-edge facilities, and a creative and curious culture. We've removed traditional boundaries of departments, divisions and disciplines and instead have an open approach that supports every researcher. This gives us the freedom to collaborate and carry out high-quality, pioneering research. Creating a space for discovery without boundaries helps us to turn our science into benefits for human health and the economy. About the role The Miguel-Aliaga lab seek to understand how organs sense and react to their environment to maintain or change our physiology. To this end, they focus on the study of the intestinal tract; certain diets, microbes or internal states can cause it to grow or shrink. Current projects explore this plasticity across scales. Following previous work on the role that the shape of the gastrointestinal (GI) tract plays in health and disease in the fruit fly, we are now working on extending this work into analysis of human GI tract shape. We have adapted our methods to analyse GI tract shape in abdominal MRI scans and now wish to scale this up to a larger dataset. We have an approved project to work with the data of the UK Biobank - a large-scale biomedical database of volunteers from across the UK. This includes genetic data and whole-body MRI scans for 100,000 participants. We aim to investigate whether in humans, there is an underlying logic to GI tract shape and 3D organ arrangement which might vary in males and females, post-pregnancy and in disease such as Crohn's disease. We are looking for an ambitious and experienced image analyst for this computational post to develop AI-based image analysis methods to extract GI tract shape data from whole-body MRI scans. What you will be doing As a PPRS at the Crick, you will be: Developing image analysis tools for analysis of GI tract shape and volume from MRI scans Developing a neural network for the automation of segmentation of the GI tract from UK Biobank whole-body MRI scans Liaising with other lab members and collaborators to link analysis of GI tract shape features with other phenotype data and genetics in the UK Biobank Contributing to the preparation of scientific manuscripts, reports and presentations About you The essential criteria you will bring PhD in Developmental Biology, Cell Biology, Computational Biology or in the final stages of PhD submission Strong level of competence and experience of the use of deep learning for image analysis in large datasets, particularly image segmentation Strong level of competence in writing macros for ImageJ/FIJI and use of other languages such as R and Python for image analysis Experience of working with large 3D datasets such as MRI scans or microCT scans Experience of image segmentation Track record of writing papers as evidenced by publications or submitted manuscripts in refereed journals Evidence of data presentation at scientific meetings About Working at the Crick Our values Everyone who works at the Crick has a valuable role to play in advancing the Crick's mission and shaping our culture! We are bold. We make space for creative, dynamic and imaginative ideas and approaches. We're not afraid to do things differently. We are open. We're highly collaborative and interactive, and make sure our activities are visible to the outside world. We are collegial. We show respect for one another, work cooperatively and support the wider community. At the Francis Crick Institute, we believe that diversity and inclusion are essential to driving innovation and scientific discovery. We are committed to creating a workplace where everyone feels valued, respected, and empowered to succeed, regardless of their background, identity, or personal circumstances. We actively encourage applications from individuals of all genders, ethnicities, abilities, and experiences. We are a Disability Confident: Committed employer and you will be asked as part of the process if you wish to apply under the scheme. We will make reasonable adjustments if you need them. If you need assistance with applying (i.e., would like to apply by phone or post) please email: Please note that interviews for this role will take place from 02/07/25.
About Us The Francis Crick Institute is Europe's largest biomedical research institute under one roof. Our world-class scientists and staff collaborate on vital research to help prevent, diagnose and treat illnesses such as cancer, heart disease, infectious diseases and neurodegenerative conditions. The Crick is a place for collaboration, innovation and exploration across many disciplines. A space where the brightest minds can pursue big and bold ideas and discover answers to crucial scientific questions. We support them in a dynamic environment which fosters excellence with state-of-the-art infrastructure, cutting-edge facilities, and a creative and curious culture. We've removed traditional boundaries of departments, divisions and disciplines and instead have an open approach that supports every researcher. This gives us the freedom to collaborate and carry out high-quality, pioneering research. Creating a space for discovery without boundaries helps us to turn our science into benefits for human health and the economy. The Research Group The Developmental Signalling Laboratory headed by Caroline Hill focuses on cell signalling in early vertebrate development and disease. Their work seeks to understand how TGF-b family signalling pathways function normally in early vertebrate development and in adult untransformed cells, and how these signalling pathways are perturbed in disease, in particular in cancer and the Marfan-related syndromes. Work in the Hill laboratory exploits the very powerful combination of early vertebrate developmental systems (zebrafish embryos), together with a variety of model tissue culture systems (human and mouse ES cell/iPS cell models), and mouse cancer models and uses a very wide range of methodologies including developmental and cell biology, cancer biology, next generation sequencing and computational modelling. The Hill lab encourages creative and independent thinking and promotes excellent training and mentoring. The group currently comprises ten people - five postdocs, two PhD students, a clinical fellow, a master's student and a senior laboratory research scientist. The Project Recent work in my lab has determined that mesoderm and endoderm specification in zebrafish embryos requires the interplay of two signalling pathways, Nodal and Fgf/Erk. We have shown that the distribution of endodermal progenitors results from a stochastic process where sustained Nodal signalling provides a competency window for the switching of bipotential progenitors to an endodermal fate. Switching is apparently stochastic and is inhibited by Fgf/Erk signalling. Cells that do not switch to the endodermal fate, differentiate to mesoderm. Thus, we hypothesise that short windows of Erk inactivity govern the switching to the endodermal fate and we have shown that these occur as cells undergo mitosis as a result of a phenomenon we are calling mitotic erasure. We now want to understand whether a similar mechanism controls the cell fate decision between mesoderm and definitive endoderm in humans, and if not, how this fate decision is controlled. To undertake this work, I am looking for a highly motivated postdoc with proven research abilities and an excellent publication record. The project will make use of human embryonic stem cells (hESCs) differentiated as 2D and 3D gastruloids. We will multiplex our novel Erk biosensor with live cell fate reporters to discover whether and how Erk signalling is involved in the cell fate decision between definitive endoderm and mesoderm. Furthermore, we will use multiomics scRNA-seq and scATAC-seq methodology, as well as whole genome CRISPR screening approaches to gain unbiased new insights into the mechanisms driving the specification of the mesodermal and endodermal lineages in humans. Postdoctoral Fellows at the Crick lead their own projects, contribute to other projects on a collaborative basis (both in the lab and with external collaborators) and may guide PhD students in their research. The ability to work in a team is essential. Key experience and competencies Essential PhD in a relevant biological science Excellent knowledge and demonstrable practical experience of working with embryonic stem cells Extensive technical expertise in differentiating embryonic stem cells to different tissue types as 2D and 3D gastruloids Technical expertise in advanced live imaging Technical expertise in molecular biology Excellent track record of writing papers as evidenced by publications or submitted manuscripts in referred journals Evidence of data presentation at scientific meetings as talks and posters Strong organisational skills and thorough record-keeping Ability to work independently and also in a team Desirable Experience in 'omics techniques and bioinformatic analysis Experience in signal transduction research About Working at the Crick Our values Everyone who works at the Crick has a valuable role to play in advancing the Crick's mission and shaping our culture! We are bold . We make space for creative, dynamic and imaginative ideas and approaches. We're not afraid to do things differently. We are open . We're highly collaborative and interactive, and make sure our activities are visible to the outside world. We are collegial . We show respect for one another, work cooperatively and support the wider community. At the Francis Crick Institute, we believe that diversity and inclusion are essential to driving innovation and scientific discovery. We are committed to creating a workplace where everyone feels valued, respected, and empowered to succeed, regardless of their background, identity, or personal circumstances. We actively encourage applications from individuals of all genders, ethnicities, abilities, and experiences. We want to ensure that everyone can apply and be part of our team and you will be asked as part of the process if you wish to apply under the Disability Confident scheme. We will make reasonable adjustments if you need them. If you need assistance with applying (i.e., would like to apply by phone or post) please email: To find out more about life at the Crick click here. What will you receive? At the Francis Crick Institute, we value our team members and are proud to offer an extensive range of benefits to support their well-being and development: Visas: Applicants for this role will be eligible for sponsorship to work in the UK, which the CRICK will fully fund for individuals and dependents. Generous Leave : 28 days of annual leave, plus three additional days over Christmas and bank holidays. Pension Scheme : Defined contribution pension with employer contributions of up to 16%. 24/7 GP consultation services. Occupational health services and mental health support programs. Eye care vouchers and discounted healthcare plans. Work-Life Balance : Childcare support allowance. Annual leave purchase options. Crick Networks offering diverse groups' support, community and inclusive social events. Discounted gym memberships, bike-to-work scheme, and shopping discounts. Subsidised on-site restaurant and social spaces for team interaction. Development & Recognition : Comprehensive training, mentoring, and a pay structure based on skills and experience.
Jun 09, 2025
Full time
About Us The Francis Crick Institute is Europe's largest biomedical research institute under one roof. Our world-class scientists and staff collaborate on vital research to help prevent, diagnose and treat illnesses such as cancer, heart disease, infectious diseases and neurodegenerative conditions. The Crick is a place for collaboration, innovation and exploration across many disciplines. A space where the brightest minds can pursue big and bold ideas and discover answers to crucial scientific questions. We support them in a dynamic environment which fosters excellence with state-of-the-art infrastructure, cutting-edge facilities, and a creative and curious culture. We've removed traditional boundaries of departments, divisions and disciplines and instead have an open approach that supports every researcher. This gives us the freedom to collaborate and carry out high-quality, pioneering research. Creating a space for discovery without boundaries helps us to turn our science into benefits for human health and the economy. The Research Group The Developmental Signalling Laboratory headed by Caroline Hill focuses on cell signalling in early vertebrate development and disease. Their work seeks to understand how TGF-b family signalling pathways function normally in early vertebrate development and in adult untransformed cells, and how these signalling pathways are perturbed in disease, in particular in cancer and the Marfan-related syndromes. Work in the Hill laboratory exploits the very powerful combination of early vertebrate developmental systems (zebrafish embryos), together with a variety of model tissue culture systems (human and mouse ES cell/iPS cell models), and mouse cancer models and uses a very wide range of methodologies including developmental and cell biology, cancer biology, next generation sequencing and computational modelling. The Hill lab encourages creative and independent thinking and promotes excellent training and mentoring. The group currently comprises ten people - five postdocs, two PhD students, a clinical fellow, a master's student and a senior laboratory research scientist. The Project Recent work in my lab has determined that mesoderm and endoderm specification in zebrafish embryos requires the interplay of two signalling pathways, Nodal and Fgf/Erk. We have shown that the distribution of endodermal progenitors results from a stochastic process where sustained Nodal signalling provides a competency window for the switching of bipotential progenitors to an endodermal fate. Switching is apparently stochastic and is inhibited by Fgf/Erk signalling. Cells that do not switch to the endodermal fate, differentiate to mesoderm. Thus, we hypothesise that short windows of Erk inactivity govern the switching to the endodermal fate and we have shown that these occur as cells undergo mitosis as a result of a phenomenon we are calling mitotic erasure. We now want to understand whether a similar mechanism controls the cell fate decision between mesoderm and definitive endoderm in humans, and if not, how this fate decision is controlled. To undertake this work, I am looking for a highly motivated postdoc with proven research abilities and an excellent publication record. The project will make use of human embryonic stem cells (hESCs) differentiated as 2D and 3D gastruloids. We will multiplex our novel Erk biosensor with live cell fate reporters to discover whether and how Erk signalling is involved in the cell fate decision between definitive endoderm and mesoderm. Furthermore, we will use multiomics scRNA-seq and scATAC-seq methodology, as well as whole genome CRISPR screening approaches to gain unbiased new insights into the mechanisms driving the specification of the mesodermal and endodermal lineages in humans. Postdoctoral Fellows at the Crick lead their own projects, contribute to other projects on a collaborative basis (both in the lab and with external collaborators) and may guide PhD students in their research. The ability to work in a team is essential. Key experience and competencies Essential PhD in a relevant biological science Excellent knowledge and demonstrable practical experience of working with embryonic stem cells Extensive technical expertise in differentiating embryonic stem cells to different tissue types as 2D and 3D gastruloids Technical expertise in advanced live imaging Technical expertise in molecular biology Excellent track record of writing papers as evidenced by publications or submitted manuscripts in referred journals Evidence of data presentation at scientific meetings as talks and posters Strong organisational skills and thorough record-keeping Ability to work independently and also in a team Desirable Experience in 'omics techniques and bioinformatic analysis Experience in signal transduction research About Working at the Crick Our values Everyone who works at the Crick has a valuable role to play in advancing the Crick's mission and shaping our culture! We are bold . We make space for creative, dynamic and imaginative ideas and approaches. We're not afraid to do things differently. We are open . We're highly collaborative and interactive, and make sure our activities are visible to the outside world. We are collegial . We show respect for one another, work cooperatively and support the wider community. At the Francis Crick Institute, we believe that diversity and inclusion are essential to driving innovation and scientific discovery. We are committed to creating a workplace where everyone feels valued, respected, and empowered to succeed, regardless of their background, identity, or personal circumstances. We actively encourage applications from individuals of all genders, ethnicities, abilities, and experiences. We want to ensure that everyone can apply and be part of our team and you will be asked as part of the process if you wish to apply under the Disability Confident scheme. We will make reasonable adjustments if you need them. If you need assistance with applying (i.e., would like to apply by phone or post) please email: To find out more about life at the Crick click here. What will you receive? At the Francis Crick Institute, we value our team members and are proud to offer an extensive range of benefits to support their well-being and development: Visas: Applicants for this role will be eligible for sponsorship to work in the UK, which the CRICK will fully fund for individuals and dependents. Generous Leave : 28 days of annual leave, plus three additional days over Christmas and bank holidays. Pension Scheme : Defined contribution pension with employer contributions of up to 16%. 24/7 GP consultation services. Occupational health services and mental health support programs. Eye care vouchers and discounted healthcare plans. Work-Life Balance : Childcare support allowance. Annual leave purchase options. Crick Networks offering diverse groups' support, community and inclusive social events. Discounted gym memberships, bike-to-work scheme, and shopping discounts. Subsidised on-site restaurant and social spaces for team interaction. Development & Recognition : Comprehensive training, mentoring, and a pay structure based on skills and experience.
This is a full-time, 1-year fixed-term position on Crick terms and conditions of employment. Summary The Quantitative Stem Cell Biology lab, headed by Dr. Silvia Santos, is seeking a Senior Laboratory Research Scientist (SLRS). The successful candidate will investigate the spatio-temporal control of cell division and cell cycle remodelling during cellular differentiation using 2D and 3D stem cell-based models of human gastrulation. The postholder will lead a research project and contribute to collaborative projects within the lab. They will benefit from excellent mentorship and training within a vibrant, collegial scientific community at the Santos lab and the Francis Crick Institute. The research group The Quantitative Stem Cell Biology lab, established in 2018 at the Francis Crick Institute, focuses on understanding cell decision-making. Current research includes regulatory mechanisms of cell fate specification, cell cycle remodeling during differentiation, and the interplay between metabolism, cell cycle, and cell fate. The lab emphasizes single-cell analysis and advanced live-cell imaging, using models such as mouse and human embryonic stem cells (ESC), 3D organoids, and mouse embryos. The team is multidisciplinary, diverse, and includes PhD students, postdoctoral fellows, and a principal research scientist. The lab promotes independent, creative thinking and provides excellent training and mentorship. Key responsibilities Lead specific research projects under the supervision of the Group Leader. Attend and participate in group meetings and seminars. Maintain accurate records of all work. Train junior colleagues as appropriate. Contribute to scientific manuscript preparation. Participate in the lab hESC feeding rota. Foster a positive and motivating lab environment. Key experience and competencies The candidate should embody the Crick values: bold, imaginative, open, dynamic, and collegial, alongside the following: Essential qualifications, experience, and competencies: PhD in a relevant Life Sciences area. Extensive experience in Molecular Biology. Experience with cell culture techniques. Experience with imaging/microscopy. Motivation and/or experience in understanding cell division in development and/or disease. Excellent organizational skills, including meticulous record-keeping. Strong interpersonal skills for effective collaboration. Proven ability to work independently, contributing to publications. Desirable qualifications, experience, and competencies: Experience with stem cell culture, particularly hESCs/iPSCs. Prior experience with image analysis. Analytical mindset. Track record of publishing scientific papers. The position will close once an appropriate candidate is found. We encourage early application.
Jun 08, 2025
Full time
This is a full-time, 1-year fixed-term position on Crick terms and conditions of employment. Summary The Quantitative Stem Cell Biology lab, headed by Dr. Silvia Santos, is seeking a Senior Laboratory Research Scientist (SLRS). The successful candidate will investigate the spatio-temporal control of cell division and cell cycle remodelling during cellular differentiation using 2D and 3D stem cell-based models of human gastrulation. The postholder will lead a research project and contribute to collaborative projects within the lab. They will benefit from excellent mentorship and training within a vibrant, collegial scientific community at the Santos lab and the Francis Crick Institute. The research group The Quantitative Stem Cell Biology lab, established in 2018 at the Francis Crick Institute, focuses on understanding cell decision-making. Current research includes regulatory mechanisms of cell fate specification, cell cycle remodeling during differentiation, and the interplay between metabolism, cell cycle, and cell fate. The lab emphasizes single-cell analysis and advanced live-cell imaging, using models such as mouse and human embryonic stem cells (ESC), 3D organoids, and mouse embryos. The team is multidisciplinary, diverse, and includes PhD students, postdoctoral fellows, and a principal research scientist. The lab promotes independent, creative thinking and provides excellent training and mentorship. Key responsibilities Lead specific research projects under the supervision of the Group Leader. Attend and participate in group meetings and seminars. Maintain accurate records of all work. Train junior colleagues as appropriate. Contribute to scientific manuscript preparation. Participate in the lab hESC feeding rota. Foster a positive and motivating lab environment. Key experience and competencies The candidate should embody the Crick values: bold, imaginative, open, dynamic, and collegial, alongside the following: Essential qualifications, experience, and competencies: PhD in a relevant Life Sciences area. Extensive experience in Molecular Biology. Experience with cell culture techniques. Experience with imaging/microscopy. Motivation and/or experience in understanding cell division in development and/or disease. Excellent organizational skills, including meticulous record-keeping. Strong interpersonal skills for effective collaboration. Proven ability to work independently, contributing to publications. Desirable qualifications, experience, and competencies: Experience with stem cell culture, particularly hESCs/iPSCs. Prior experience with image analysis. Analytical mindset. Track record of publishing scientific papers. The position will close once an appropriate candidate is found. We encourage early application.
Details of the role: This is a full-time, fixed-term (two years) position on Crick terms and conditions of employment. About us The Francis Crick Institute is Europe's largest biomedical research institute under one roof. Our world-class scientists and staff collaborate on vital research to help prevent, diagnose, and treat illnesses such as cancer, heart disease, infectious diseases, and neurodegenerative conditions. The Crick is a place for collaboration, innovation, and exploration across many disciplines. A space where the brightest minds can pursue big and bold ideas and discover answers to crucial scientific questions. We support them in a dynamic environment which fosters excellence with state-of-the-art infrastructure, cutting-edge facilities, and a creative and curious culture. We've removed traditional boundaries of departments, divisions, and disciplines and instead have an open approach that supports every researcher. This gives us the freedom to take risks and carry out high-quality, pioneering research. Creating a space for discovery without boundaries helps us to turn our science into benefits for human health and the economy. About the role We are seeking an experienced Postdoctoral Project Research Scientist to join our team. In this role, you will both lead your own independent project(s) and contribute to the development of innovative tools and technologies that advance the lab's research program. You will be part of a collaborative and diverse group dedicated to uncovering how a functional, beating heart is formed during development. Your work will involve applying in-depth technical expertise in cutting-edge imaging technologies, image analysis techniques, and biophysical approaches. The specific goals and direction of the project(s) will be shaped in close consultation with the supervisor and tailored to your background and interests. The heart is the first organ to form and function during embryonic development. A key step during vertebrate heart development is chamber maturation - a poorly-understood morphogenetic process critical for heart function. During this process, the myocardial wall of the ventricle and atrium transforms from a single-layered epithelium into a complex 3D topological meshwork architecture (Priya et al., 2021, Nature; bioRxiv 2024.07.24.604962; bioRxiv, 2025.03.07.641942). How this topological complexity is achieved is unknown, as are the underlying mechanisms that shape these crucial anatomical structures. In our lab, we aim to unravel the underlying mechanical, molecular, and geometric interactions that transform a developing heart from a simple epithelium into a highly intricate functional organ. We combine the excellent tractability of zebrafish embryos with quantitative imaging, transcriptomics, biophysics, genetics, and predictive theoretical modelling to answer fundamental questions driving organ morphogenesis. What you will be doing: As a PPRS you will: Develop and establish new tools and techniques - advanced 4D live imaging of zebrafish hearts, image analysis pipelines, biophysical methods for measuring mechanical forces, and gene-editing tools. Conceptualize and lead research project(s) Provide expert guidance and technical support to lab members, fostering knowledge exchange and skill development. Contribute to other projects on a collaborative basis, both in the lab and with external collaborators. Actively contribute to the development and publication of scientific manuscripts Help cultivate a collaborative, inclusive, and intellectually stimulating lab environment. About you You will bring PhD (or near completion) in cell biology, developmental biology, or biophysics. Proven expertise in advanced confocal and light-sheet microscopy, as shown by publications. Excellent skills in molecular biology. Experience in embryological techniques (zebrafish/fly/mouse) as well as gene editing methods. Demonstrated ability to write scientific papers, as shown by publications and/or preprints in relevant fields.
Jun 08, 2025
Full time
Details of the role: This is a full-time, fixed-term (two years) position on Crick terms and conditions of employment. About us The Francis Crick Institute is Europe's largest biomedical research institute under one roof. Our world-class scientists and staff collaborate on vital research to help prevent, diagnose, and treat illnesses such as cancer, heart disease, infectious diseases, and neurodegenerative conditions. The Crick is a place for collaboration, innovation, and exploration across many disciplines. A space where the brightest minds can pursue big and bold ideas and discover answers to crucial scientific questions. We support them in a dynamic environment which fosters excellence with state-of-the-art infrastructure, cutting-edge facilities, and a creative and curious culture. We've removed traditional boundaries of departments, divisions, and disciplines and instead have an open approach that supports every researcher. This gives us the freedom to take risks and carry out high-quality, pioneering research. Creating a space for discovery without boundaries helps us to turn our science into benefits for human health and the economy. About the role We are seeking an experienced Postdoctoral Project Research Scientist to join our team. In this role, you will both lead your own independent project(s) and contribute to the development of innovative tools and technologies that advance the lab's research program. You will be part of a collaborative and diverse group dedicated to uncovering how a functional, beating heart is formed during development. Your work will involve applying in-depth technical expertise in cutting-edge imaging technologies, image analysis techniques, and biophysical approaches. The specific goals and direction of the project(s) will be shaped in close consultation with the supervisor and tailored to your background and interests. The heart is the first organ to form and function during embryonic development. A key step during vertebrate heart development is chamber maturation - a poorly-understood morphogenetic process critical for heart function. During this process, the myocardial wall of the ventricle and atrium transforms from a single-layered epithelium into a complex 3D topological meshwork architecture (Priya et al., 2021, Nature; bioRxiv 2024.07.24.604962; bioRxiv, 2025.03.07.641942). How this topological complexity is achieved is unknown, as are the underlying mechanisms that shape these crucial anatomical structures. In our lab, we aim to unravel the underlying mechanical, molecular, and geometric interactions that transform a developing heart from a simple epithelium into a highly intricate functional organ. We combine the excellent tractability of zebrafish embryos with quantitative imaging, transcriptomics, biophysics, genetics, and predictive theoretical modelling to answer fundamental questions driving organ morphogenesis. What you will be doing: As a PPRS you will: Develop and establish new tools and techniques - advanced 4D live imaging of zebrafish hearts, image analysis pipelines, biophysical methods for measuring mechanical forces, and gene-editing tools. Conceptualize and lead research project(s) Provide expert guidance and technical support to lab members, fostering knowledge exchange and skill development. Contribute to other projects on a collaborative basis, both in the lab and with external collaborators. Actively contribute to the development and publication of scientific manuscripts Help cultivate a collaborative, inclusive, and intellectually stimulating lab environment. About you You will bring PhD (or near completion) in cell biology, developmental biology, or biophysics. Proven expertise in advanced confocal and light-sheet microscopy, as shown by publications. Excellent skills in molecular biology. Experience in embryological techniques (zebrafish/fly/mouse) as well as gene editing methods. Demonstrated ability to write scientific papers, as shown by publications and/or preprints in relevant fields.
Four Squared Recruitment Ltd
Cambridge, Cambridgeshire
Environmental Risk Modeller Location: Cambridge, Cambridgeshire (Hybrid) Salary: 60-85k Job Type: Full-time, Permanent About the Role We are seeking a quantitative modeller to support the development of climate physical risk and nature modelling efforts for an innovative and fast-growing organisation. The successful candidate will be responsible for quantifying the impacts and dependencies of businesses on climate and nature, working alongside a talented team of modellers, economists, data scientists, and software engineers. This is an exciting opportunity for an ambitious individual looking to work on cutting-edge analytics with some of the world s largest and most forward-thinking corporations. Key Responsibilities Develop models using novel techniques to assess risks from climate change and nature, translating complex scientific concepts into quantified financial impacts for businesses. Write Python code to integrate models into the company s analytics platform. Build and analyse geospatial data layers to support risk modelling. Deliver actionable insights and analytics relevant to corporate decision-making. Act as a subject matter expert on nature and climate-related risks and opportunities. Collaborate with internal teams and clients, requiring a minimum of three days per week in the Cambridge office. Essential Skills & Experience A Bachelor s degree in natural sciences, physics, engineering, or a related field. Experience delivering environmental or sustainability-related projects to corporate clients. Strong knowledge of mathematical modelling, including statistics, geospatial analysis, and probability, with practical applications to real-world problems. Proficiency in Python (preferred), R, or MATLAB for scientific programming. Experience working with large geospatial and environmental datasets (e.g., CMIP6, SSPs, or nature data layers). Strong research skills with the ability to translate data into actionable models and insights. Excellent communication skills, with the ability to present complex scientific concepts to non-technical audiences. Ability to work effectively in a fast-paced environment, managing multiple projects while collaborating with a diverse team of scientists and engineers. Desirable Skills Postdoctoral research experience in a relevant field. Experience in model development (e.g., natural catastrophe modelling, risk quantification). Cross-disciplinary expertise in areas such as natural sciences, agronomy, or environmental economics. Experience quantifying the economic impact of climate and nature-related risks to inform business or government decision-making. Why Join? Be part of a rapidly growing organisation at the forefront of climate and environmental risk modelling. Work on high-impact projects with leading global corporations. Collaborate with a highly skilled team of scientists, engineers, and industry experts. Competitive salary and opportunities for career progression.
Feb 21, 2025
Full time
Environmental Risk Modeller Location: Cambridge, Cambridgeshire (Hybrid) Salary: 60-85k Job Type: Full-time, Permanent About the Role We are seeking a quantitative modeller to support the development of climate physical risk and nature modelling efforts for an innovative and fast-growing organisation. The successful candidate will be responsible for quantifying the impacts and dependencies of businesses on climate and nature, working alongside a talented team of modellers, economists, data scientists, and software engineers. This is an exciting opportunity for an ambitious individual looking to work on cutting-edge analytics with some of the world s largest and most forward-thinking corporations. Key Responsibilities Develop models using novel techniques to assess risks from climate change and nature, translating complex scientific concepts into quantified financial impacts for businesses. Write Python code to integrate models into the company s analytics platform. Build and analyse geospatial data layers to support risk modelling. Deliver actionable insights and analytics relevant to corporate decision-making. Act as a subject matter expert on nature and climate-related risks and opportunities. Collaborate with internal teams and clients, requiring a minimum of three days per week in the Cambridge office. Essential Skills & Experience A Bachelor s degree in natural sciences, physics, engineering, or a related field. Experience delivering environmental or sustainability-related projects to corporate clients. Strong knowledge of mathematical modelling, including statistics, geospatial analysis, and probability, with practical applications to real-world problems. Proficiency in Python (preferred), R, or MATLAB for scientific programming. Experience working with large geospatial and environmental datasets (e.g., CMIP6, SSPs, or nature data layers). Strong research skills with the ability to translate data into actionable models and insights. Excellent communication skills, with the ability to present complex scientific concepts to non-technical audiences. Ability to work effectively in a fast-paced environment, managing multiple projects while collaborating with a diverse team of scientists and engineers. Desirable Skills Postdoctoral research experience in a relevant field. Experience in model development (e.g., natural catastrophe modelling, risk quantification). Cross-disciplinary expertise in areas such as natural sciences, agronomy, or environmental economics. Experience quantifying the economic impact of climate and nature-related risks to inform business or government decision-making. Why Join? Be part of a rapidly growing organisation at the forefront of climate and environmental risk modelling. Work on high-impact projects with leading global corporations. Collaborate with a highly skilled team of scientists, engineers, and industry experts. Competitive salary and opportunities for career progression.
