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Entry Level Engineering Geologist Location: Watford Reference: BY1893 Salary: 26,000 - 28,000 This is a great opportunity for a recent Geology, Geoscience or Geotechnical Engineering graduate to join a team of Ground Investigation specialist around the South East. The position provides opportunity for specialist training, support and varied project exposure amongst a team of Geotechnical and Geo-Environmental consultants. The Entry Level Engineering Geologist selected will be working on a range of geo-environmental and geotechnical projects, writing technical reports, supervising site investigations, borehole logging, groundwater and gas monitoring, soil and rock logging, water sampling and liaising with clients. The Entry Level Engineering Geologist position offers: A competitive salary ( 26,000 - 28,000) Attractive benefits including use of company vehicles. Enhanced company pension scheme. Work on a variety of exciting projects with a supportive team of specialists. Opportunities for career progression and specialist training. To be considered for this Entry Level Engineering Geologist role you will: Have degree level education in geology, geotechnical engineering, geoscience or a similar, relevant subject. Hold a valid UK Driving licence. Be commutable to Watford. Have a full right to work in the UK. Be keen to develop skills and work with a team in a range of environments. If you are interested in this Entry Level Engineering Geologist opportunity and believe you have the qualifications and experience required then please apply now! If you are interested in this or other roles in Geotechnical Engineering/Consulting roles please do not hesitate to contact Beth Young on (url removed) or call (phone number removed). We have many more vacancies available on our website. Please refer to (url removed). This is a permanent role. Penguin Recruitment is operating as a Recruitment Agency in respect to this position.

Job Description: Job Title: Heating engineer Job Type: Full time Location: Westminster Salary: £34,000 - £38,000 basic salary, OTE £50,000 (overtime + call-out available) Skilled Careers are seeking a permanent heating engineer to work in social housing homes in the Westminster area. We are looking for a highly skilled Heating engineer that has minimum 5 years experience in installing, maintaining and repairing heating systems. Key Responsibilities As a Heating Engineer, your role will involve diagnosing and resolving faults in heating systems and gas appliances, ensuring all work is completed in accordance with health and safety regulations. You will be the face of the company, interacting with tenants and ensuring they receive excellent customer service. This is a rewarding and dynamic role where you will use your expertise to make a real difference in the homes of social housing residents. Key Knowledge, Skills and Experience: Good communication and customer service skills Able to Fault find, Diagnose and Repair Boiler systems in a timely manner At least 5 years experience in Gas/Heating engineering (particularly social housing) Thorough knowledge of heating systems HIU experience (ideal but not essential) Proven record of resolving issues efficiently and in a timely manner whilst maintaining customer safety Qualifications and Certificates ACS Qualifications (CCN1, CENWAT, CKR1, HTR1) Full UK Driving licence Benefits: Holiday entitlement Company pension Bank holidays Sick pay Private medical insurance If you meet the qualifications and have the necessary experience, we encourage you to apply today for this exiting opportunity to join our skilled team of Heating engineers

Postdoctoral Fellow - Hill lab Reporting to: Caroline Hill, Head of Developmental Signalling Laboratory Contact term: This is a full-time, fixed term 4 years position on Crick terms and conditions of employment. About Us The Francis Crick Institute is Europe's largest biomedical research institute under one roof. Our world-class scientists and staff collaborate on vital research to help prevent, diagnose and treat illnesses such as cancer, heart disease, infectious diseases and neurodegenerative conditions. The Crick is a place for collaboration, innovation and exploration across many disciplines. A space where the brightest minds can pursue big and bold ideas and discover answers to crucial scientific questions. We support them in a dynamic environment which fosters excellence with state-of-the-art infrastructure, cutting-edge facilities, and a creative and curious culture. We've removed traditional boundaries of departments, divisions and disciplines and instead have an open approach that supports every researcher. This gives us the freedom to collaborate and carry out high-quality, pioneering research. Creating a space for discovery without boundaries helps us to turn our science into benefits for human health and the economy. The Research Group The Developmental Signalling Laboratory headed by Caroline Hill focuses on cell signalling in early vertebrate development and disease - see . Their work seeks to understand how TGF-b family signalling pathways function normally in early vertebrate development and in adult untransformed cells, and how these signalling pathways are perturbed in disease, in particular in cancer and the Marfan-related syndromes. Work in the Hill laboratory exploits the very powerful combination of early vertebrate developmental systems (zebrafish embryos), together with a variety of model tissue culture systems (human and mouse ES cell/iPS cell models), and mouse cancer models and uses a very wide range of methodologies including developmental and cell biology, cancer biology, next generation sequencing and computational modelling. The Hill lab encourages creative and independent thinking and promotes excellent training and mentoring. The group currently comprises ten people - five postdocs, two PhD students, a clinical fellow, a master's student and a senior laboratory research scientist. For selected recent publications see: The Project Recent work in my lab has determined that mesoderm and endoderm specification in zebrafish embryos requires the interplay of two signalling pathways, Nodal and Fgf/Erk. We have shown that the distribution of endodermal progenitors results from a stochastic process where sustained Nodal signalling provides a competency window for the switching of bipotential progenitors to an endodermal fate. Switching is apparently stochastic and is inhibited by Fgf/Erk signalling. Cells that do not switch to the endodermal fate, differentiate to mesoderm. Thus, we hypothesise that short windows of Erk inactivity govern the switching to the endodermal fate and we have shown that these occur as cells undergo mitosis as a result of a phenomenon we are calling mitotic erasure. We now want to understand whether a similar mechanism controls the cell fate decision between mesoderm and definitive endoderm in humans, and if not, how this fate decision is controlled. To undertake this work, I am looking for a highly motivated postdoc with proven research abilities and an excellent publication record. The project will make use of human embryonic stem cells (hESCs) differentiated as 2D and 3D gastruloids. We will multiplex our novel Erk biosensor with live cell fate reporters to discover whether and how Erk signalling is involved in the cell fate decision between definitive endoderm and mesoderm. Furthermore, we will use multiomics scRNA-seq and scATAC-seq methodology, as well as whole genome CRISPR screening approaches to gain unbiased new insights into the mechanisms driving the specification of the mesodermal and endodermal lineages in humans. Postdoctoral Fellows at the Crick lead their own projects, contribute to other projects on a collaborative basis (both in the lab and with external collaborators) and may guide PhD students in their research. The ability to work in a team is essential. Key experience and competencies The post holder should embody and demonstrate our core Crick values: Bold; Imaginative; Open; Dynamic; Collegial Essential PhD in a relevant biological science Excellent knowledge and demonstrable practical experience of working with embryonic stem cells Extensive technical expertise in differentiating embryonic stem cells to different tissue types as 2D and 3D gastruloids Technical expertise in advanced live imaging Technical expertise in molecular biology Excellent track record of writing papers as evidenced by publications or submitted manuscripts in referred journals Evidence of data presentation at scientific meetings as talks and posters Strong organisational skills and thorough record-keeping Ability to work independently and also in a team Desirable Experience in 'omics techniques and bioinformatic analysis Experience in signal transduction research About Working at the Crick Our values Everyone who works at the Crick has a valuable role to play in advancing the Crick's mission and shaping our culture! We are bold. We make space for creative, dynamic and imaginative ideas and approaches. We're not afraid to do things differently. We are open. We're highly collaborative and interactive, and make sure our activities are visible to the outside world. We are collegial. We show respect for one another, work cooperatively and support the wider community. At the Francis Crick Institute, we believe that diversity and inclusion are essential to driving innovation and scientific discovery. We are committed to creating a workplace where everyone feels valued, respected, and empowered to succeed, regardless of their background, identity, or personal circumstances. We actively encourage applications from individuals of all genders, ethnicities, abilities, and experiences. We want to ensure that everyone can apply and be part of our team and you will be asked as part of the process if you wish to apply under the Disability Confident scheme. We will make reasonable adjustments if you need them. If you need assistance with applying (i.e., would like to apply by phone or post) please email: To find out more about life at the Crick click here . What will you receive? At the Francis Crick Institute, we value our team members and are proud to offer an extensive range of benefits to support their well-being and development: Visas: Applicants for this role will be eligible for sponsorship to work in the UK Generous Leave: 28 days of annual leave, plus three additional days over Christmas and bank holidays. Pension Scheme: Defined contribution pension with employer contributions of up to 16%. Health & Well-being: 24/7 GP consultation services. Occupational health services and mental health support programs. Eye care vouchers and discounted healthcare plans. Work-Life Balance: Back-up care for dependents. Childcare support allowance. Annual leave purchase options. Crick Networks offering diverse groups' support, community and inclusive social events. Perks: Discounted gym memberships, bike-to-work scheme, and shopping discounts. Subsidised on-site restaurant and social spaces for team interaction. Development & Recognition: Comprehensive training, mentoring, and a pay structure based on skills and experience.

Title: Senior Validation Specialist Location: Slough Visa and Relocation support is offered with this role. Today, Lonza is a global leader in life sciences operating across five continents. While we work in science, there's no magic formula to how we do it. Our greatest scientific solution is talented people working together, devising ideas that help businesses to help people. In exchange, we let our people own their careers. Their ideas, big and small, genuinely improve the world. And that's the kind of work we want to be part of. The role: The Senior Validation Specialist at Lonza is responsible for working with the Head of Validation in defining the vision and strategy for the Commissioning, Qualification, and Validation (CQV) department. You will be working with colleagues and internal customers sharing knowledge and experience, in all technical areas and aspects of project work throughout the validation lifecycle and determining innovation and identifying compliance requirements in the validation lifecycle Be a technical Subject Matter Expert for at least one area of competency (CSE, Sterilisation, Gas Testing, Clean Room, Equipment Qualification)! Key responsibilities: Cultivate positive relationships between QA, Manufacturing, Quality Control, Development Services, Project Management, business services, and maintenance departments. Support and successfully implement a risk-based approach to CQV. Drive updates to policies & procedures in line with current regulations and industry standards, continuously challenging and improving working practices and performance. Provide support and input for site projects and initiatives, ensuring that the CQV team is aligned. Manage changes aligned with business objectives and support the CQV Team through change to ensure positive outcomes. Troubleshoot technical issues to guarantee smooth operations. Contribute towards supporting Deviation, CAPA, Out Of Specification (OOS), and Out Of Trend (OOT) investigations. Key requirements: BSc/MSc or equivalent experience in Mechanical Engineering, Chemical Engineering, Electronic/Electrical Engineering, Automation, Biological Sciences, or Chemistry. Be a technical Subject Matter Expert for at least one area of competency (CSE, Sterilisation, Gas Testing, Clean Room, Equipment Qualification) Proven knowledge of Regulatory and cGMP guidelines, contributing to quality records (Deviations, Investigations, CAPA, and Change Control). Proactively seeks to understand internal/external customer and market needs. Develops insights that can be used to improve customer happiness and other important measurements. Employs meticulous methods to track and analyse customer performance indicators for continuous improvement. Every day, Lonza's products and services have a positive impact on millions of people. For us, this is not only a great privilege, but also a great responsibility. How we achieve our business results is just as important as the achievements themselves. At Lonza, we respect and protect our people and our environment. Any success we achieve is no success at all if not achieved ethically. People come to Lonza for the challenge and creativity of solving complex problems and developing new ideas in life sciences. In return, we offer the satisfaction that comes with improving lives all around the world. The satisfaction that comes with making a meaningful difference.

Job Description: Job Title: Heating engineer Job Type: Full time Location: Islington Salary: £34,000 - £38,000 basic salary, OTE £50,000 (overtime + call-out available) Skilled Careers are seeking a permanent heating engineer to work in social housing homes in the Islington area. We are looking for a highly skilled Heating engineer that has minimum 5 years experience in installing, maintaining and repairing heating systems. Key Responsibilities As a Heating Engineer, your role will involve diagnosing and resolving faults in heating systems and gas appliances, ensuring all work is completed in accordance with health and safety regulations. You will be the face of the company, interacting with tenants and ensuring they receive excellent customer service. This is a rewarding and dynamic role where you will use your expertise to make a real difference in the homes of social housing residents. Key Knowledge, Skills and Experience: Good communication and customer service skills Able to Fault find, Diagnose and Repair Boiler systems in a timely manner At least 5 years experience in Gas/Heating engineering (particularly social housing) Thorough knowledge of heating systems HIU experience (ideal but not essential) Proven record of resolving issues efficiently and in a timely manner whilst maintaining customer safety Qualifications and Certificates ACS Qualifications (CCN1, CENWAT, CKR1, HTR1) Full UK Driving licence Benefits: Holiday entitlement Company pension Bank holidays Sick pay Private medical insurance If you meet the qualifications and have the necessary experience, we encourage you to apply today for this exiting opportunity to join our skilled team of Heating engineers

Postdoctoral Research Scientist in Metagenomics Job Title Postdoctoral Research Scientist in Metagenomics Post Number Closing Date 8 Jul 2025 Grade SC6 Starting Salary Salary: £36,720-£42,000 Funding End Date 16 Jul 2026 Hours per week 37 Project Title Microbial drivers of atmospheric methane emission Expected/Ideal Start Date 01 Aug 2025 Months Duration 9 Interview Date 14 Jul 2025 Job Description Main Purpose of the Job Applications are invited for a Research Scientist to join the Laboratory of Dr Hildebrand at the Quadram Institute Bioscience (QIB), Norwich, UK. This post is part of a NERC project revealing the role of ammonia oxidising archaea in methane oxidation in the environment. The postholder will work with sequencing data derived from cultivated and natural soil microbiomes, to understand the role of prokaryotes (Archaea and Bacteria) in mitigating greenhouse gas emissions. Specifically, pipelines for SIP-enriched metagenomic sequencing and functional-targeted amplicon sequencing data will be developed (based on existing work in the group) and applied to interpret experiments conducted in the laboratory of collaborators. The project holder will use metagenomics (similar to doi:10.1038/s-6, 10 15314, 10.1186/s5-1) to profile both taxonomic and functional compositions of for SIP-enriched metagenomic sequencing and functional-targeted amplicon sequencing and metatranscriptomics data. The bioinformatic tools will be developed to analyse and correct these data types, the statistical workflows established to interpret and understand how ammonia oxidising microorganisms respond to methane in soil. Long-term, this work will contribute to reducing the impact of climate changes by manipulating existing microbial communities, and understanding how healthy soil microbiomes are established and maintained. Key Relationships The post holder will work closely with other group members, the line manager Dr Falk Hildebrand and collaborators Profs Laura Lehtovirta-Morley and Fred Warren. The applicant is expected to help in the supervision of junior group members and to represent the group at trainings. The applicant will have direct access to established PacBio/ONT, Hi-C and single cell sequencing facilities, as well as one of UK's largest HPC cluster at the NRP. Main Activities & Responsibilities Percentage Process and analyse soil metagenomes/metatranscriptomes 30 Use machine learning/statistics to characterize & predict community states 25 Develop new bioinformatic tools to process specialized metagenomic sequence data 25 Support group with tasks such as outreach, student supervision, writing grants 15 As agreed with the line manager, any other duties commensurate with the nature of the post, for example, contributing to the work of Institute committees 5 Person Profile Education & Qualifications Requirement Importance PhD in Bioinformatics, Soil science, Ecology or Microbiology, or equivalent experience Essential Specialist Knowledge & Skills Requirement Importance Programming skills (e.g. C++, Perl, python or R) Essential Understanding of microbiomes, preferably environmental and soil microbiomes Essential Ability to troubleshoot and solve problems Essential Initiative and a desire to learn, to innovate, and to move out of their comfort zone Essential Ability to work independently on research projects Desirable Requirement Importance Familiarity with sequencing related, metagenomics, or metatranscriptomics, or soil microbial bioinformatics Essential Bioinformatics experience Essential Proven track-record of research output at the appropriate level Essential Experience grant writing or supervising lab members Desirable Interpersonal & Communication Skills Requirement Importance Excellent communication skills, both written and oral Essential Promotes and strives for continuous improvement Essential Excellent interpersonal skills, with the ability to work alone and as part of a team Essential Reliable and conscientious Essential Additional Requirements Requirement Importance Attention to detail Essential Promotes equality and values diversity Essential Willingness to embrace the expected values and behaviours of all staff at the Institute, ensuring it is a great place to work Essential Able to present a positive image of self and the Institute, promoting both the international reputation and public engagement aims of the Institute Essential Willingness to work outside standard working hours when required Essential Willingness to undertake any necessary training for the role Essential Who We Are Quadram Institute Bioscience The Quadram Institute is at the forefront of a new interface between food science, gut biology and health, developing solutions to worldwide challenges in food-related disease and human health. We are engaged in fundamental and translational food and health research, alongside clinical studies, endoscopy and industry, working together to become a leading international hub for food and health research, combining scientific excellence and clinical expertise, delivering impacts on patient care and accelerating innovation. The Quadram Institute is a diverse and multicultural scientific community. We thrive on our international and European links, appointing staff from across the world. Any candidate who would like further information on current or anticipated immigration requirements can contact the HR Team on (0) or . The Hildebrand group uses meta omics to research the diversity, community interactions, and evolution of microbes in communities. Currently the group has projects in both human associated and environmental (soil, lakes) microbiomes, for which custom bioinformatic solutions are developed in-house to enable a wholistic microbiome exploration. We advocate strain-resolved metagenomics and develop the numerical solutions to work with MAGs intra-specific phylogenies. For representative publications relevant to the post please see (doi: 10.1016/j.chom.2023.05.024 , 10.1101/2024.09.09. , 10.1016/j.chom.2021.05.008) and for group information. The Quadram Institute is based on the Norwich Research Park, which is one of the largest single-site concentrations of research in food, genomics, and health in Europe. The Park hosts 4 BBSRC Institutes (including Earlham), 17,000 students, 3,000 full-time researchers and clinicians, and over 115 companies. The outstanding reputation of our researchers is internationally recognised, with 10 of the Park's scientists in the top 1% of the "most highly cited" in the world, including Dr Falk Hildebrand. Research Scientist (Soil metagenomics) Applications are invited for a Research Scientist to join the Laboratory of Dr Hildebrand at Quadram Institute, Norwich, UK. Background: This post is part of the NERC project "Identifying novel microbial drivers to mitigate atmospheric methane emission". Methane is a powerful greenhouse gas, and we aim to reveal the role of ammonia oxidizing Archaea in methane oxidation in the environment. The project will determine how methane affects soil microbial communities, and how specific soil microorganisms respond to methane and metabolise it. The postholder will work with sequencing data derived from cultivated and natural soil microbiomes, to understand the roleof prokaryotes (Archaea and Bacteria) in mitigating greenhouse gas emissions. The role: The project holder will use metagenomics (similar to doi:10.1038/s-6, 10 15314, 10.1186/s5-1) to profile both taxonomic and functional compositions of for SIP-enriched metagenomic and metatranscriptomic sequencing and functional-targeted amplicon sequencing data, interpreting experiments conducted in the laboratory of Prof Laura Lehtovirta-Morley. The bioinformatic tools will be developed to analyse and correct these data types, the statistical workflows established to interpret and understand how microorganisms respond to methane in both pristine and laboratory-based soil communities, building on tools available in the Hildebrand group . Long-term, this work will advance our understanding of biogeochemical cycling, contribute to reducing the impact of climate change by manipulating existing microbial communities, and understanding how healthy soil microbiomes are established, and maintained. The environment: The Hildebrand group uses metagenomics to research the diversity, community interactions, and evolution of microbes in communities using custom software solutions. The Lehtovirta-Morley group explores environmental microbiomes and biogeochemical cycling using both cultivation-independent and cultivation-dependent experiments. Both groups collaborate closely on microbial archaeal research in soils. The research is situated at the Norwich Research Park (NRP) UK, that encompasses the University of East Anglia, 4 BBSRC Institute, > 15 companies, 3,000 researchers and clinicians, 17,000 students. Norwich ranked in the top 10 for UK cities with a beautiful, historical town centre and an active gastropub & coffee aficionado scene. The applicant is expected to help in the supervision of junior group members and to represent the group at trainings. The applicant will have direct access to established PacBio/ONT, Hi-C and single cell sequencing facilities, as well as one of UK's largest HPC cluster at the NRP. The ideal candidate: The applicant needs to hold a PhD (or equivalent) in biology, bioinformatics . click apply for full job details

CHP Service Engineer South (East London) £44,000 to £49,500 + Overtime (OTE £65k) + Van NEOS Engineering are partnered with an established energy solutions provider seeking a skilled and motivated CHP Service Engineer to join their team covering sites across the South, with a focus on East London. This is a brilliant opportunity for an experienced Engineer or Technician to take ownership of on-site generation and energy plant, driving performance, reliability, and efficiency. Key Responsibilities: Carry out day-to-day operations and maintenance of CHP plant, including fault diagnosis, repairs and preventative servicing. Minimise downtime through prompt breakdown response and effective planned maintenance. Support and mentor Operations Technicians, passing on knowledge to build team capability. Maintain a stock of essential spare parts and ensure efficient use of company resources to control costs. Champion Health, Safety, Quality, and Environmental best practice, complying with all company and legislative requirements. Supervise contractors when required and ensure high standards on all sites. Provide emergency call out cover on a rota basis and occasional overnight stays as needed. Requirements: Strong experience in electrical, mechanical and heat maintenance ideally within CHP, Gas Peaker Plants, PV, Energy Storage or HVAC systems. Recognised electrical skill level and ability to work on electric control systems (12v DC 415v AC). Gassafe accreditation or willingness to achieve this during probation. 18th Edition electrical qualification or ability to complete within probation. Full UK driving licence. Self-motivated, organised and able to manage workload independently whilst supporting the wider team. Computer literate with a proactive attitude to record keeping and site reporting. What We Offer: Competitive basic salary £44,000 to £49,500 + Overtime (OTE £65k) + Van Overtime available. Ongoing training and development with clear pathways to enhance your skills and grow within the company. 40 hours per week, with overtime available. Join a respected name in energy, with a real commitment to professional development. Be part of a supportive team where your expertise genuinely makes a difference to clean, efficient energy generation. Please apply with an up-to-date CV and feel free to include a short cover letter explaining why this role is right for you. Thanks for taking the time to apply. We do our best to respond to every applicant, but due to high volumes, if you haven t heard from us within 7 days, unfortunately you have not been successful on this occasion. We encourage you to keep an eye on our website for future opportunities. We kindly ask that candidates requiring sponsorship do not apply, as our client is currently unable to offer visa sponsorship. Any applications requiring sponsorship will be automatically rejected.

Job Title: Postdoctoral Project Research Scientist (PPRS) Details of the role : 2yr FTC, full-time. Working pattern: Monday - Friday. Salary : From £45,500 pa with benefits, subject to skills and experience Application closing date: 25/06/:59 GMT About us The Francis Crick Institute is Europe's largest biomedical research institute under one roof. Our world-class scientists and staff collaborate on vital research to help prevent, diagnose and treat illnesses such as cancer, heart disease, infectious diseases and neurodegenerative conditions. The Crick is a place for collaboration, innovation and exploration across many disciplines. A space where the brightest minds can pursue big and bold ideas and discover answers to crucial scientific questions. We support them in a dynamic environment which fosters excellence with state-of-the-art infrastructure, cutting-edge facilities, and a creative and curious culture. We've removed traditional boundaries of departments, divisions and disciplines and instead have an open approach that supports every researcher. This gives us the freedom to collaborate and carry out high-quality, pioneering research. Creating a space for discovery without boundaries helps us to turn our science into benefits for human health and the economy. About the role The Miguel-Aliaga lab seek to understand how organs sense and react to their environment to maintain or change our physiology. To this end, they focus on the study of the intestinal tract; certain diets, microbes or internal states can cause it to grow or shrink. Current projects explore this plasticity across scales. Following previous work on the role that the shape of the gastrointestinal (GI) tract plays in health and disease in the fruit fly, we are now working on extending this work into analysis of human GI tract shape. We have adapted our methods to analyse GI tract shape in abdominal MRI scans and now wish to scale this up to a larger dataset. We have an approved project to work with the data of the UK Biobank - a large-scale biomedical database of volunteers from across the UK. This includes genetic data and whole-body MRI scans for 100,000 participants. We aim to investigate whether in humans, there is an underlying logic to GI tract shape and 3D organ arrangement which might vary in males and females, post-pregnancy and in disease such as Crohn's disease. We are looking for an ambitious and experienced image analyst for this computational post to develop AI-based image analysis methods to extract GI tract shape data from whole-body MRI scans. To learn more about team/Group Leader and projects currently being undertaken here . What you will be doing As a PPRS at the Crick, you will be: Developing image analysis tools for analysis of GI tract shape and volume from MRI scans Developing a neural network for the automation of segmentation of the GI tract from UK Biobank whole-body MRI scans Liaising with other lab members and collaborators to link analysis of GI tract shape features with other phenotype data and genetics in the UK Biobank Contributing to the preparation of scientific manuscripts, reports and presentations About you The essential criteria you will bring PhD in Developmental Biology, Cell Biology, Computational Biology or in the final stages of PhD submission Strong level of competence and experience of the use of deep learning for image analysis in large datasets, particularly image segmentation Strong level of competence in writing macros for ImageJ/FIJI and use of other languages such as R and Python for image analysis Experience of working with large 3D datasets such as MRI scans or microCT scans Experience of image segmentation Track record of writing papers as evidenced by publications or submitted manuscripts in refereed journals Evidence of data presentation at scientific meetings To see the complete job description, click here . About Working at the Crick Our values Everyone who works at the Crick has a valuable role to play in advancing the Crick's mission and shaping our culture! We are bold . We make space for creative, dynamic and imaginative ideas and approaches. We're not afraid to do things differently. We are open . We're highly collaborative and interactive, and make sure our activities are visible to the outside world. We are collegial . We show respect for one another, work cooperatively and support the wider community. At the Francis Crick Institute, we believe that diversity and inclusion are essential to driving innovation and scientific discovery. We are committed to creating a workplace where everyone feels valued, respected, and empowered to succeed, regardless of their background, identity, or personal circumstances. We actively encourage applications from individuals of all genders, ethnicities, abilities, and experiences. We are a Disability Confident: Committed employer and you will be asked as part of the process if you wish to apply under the scheme. We will make reasonable adjustments if you need them. If you need assistance with applying (i.e., would like to apply by phone or post) please email: To find out more about life at the Crick click here . What will you receive? At the Francis Crick Institute, we value our team members and are proud to offer an extensive range of benefits to support their well-being and development: Visas : Applicants for this role will be eligible for sponsorship to work in the UK Generous Leave : 28 days of annual leave, plus three additional days over Christmas and bank holidays. Pension Scheme: Defined contribution pension with employer contributions of up to 16%. Health & Well-being : 24/7 GP consultation services. Occupational health services and mental health support programs. Eye care vouchers and discounted healthcare plans. Work-Life Balance : Back-up care for dependents. Childcare support allowance. Annual leave purchase options. Crick Networks offering diverse groups' support, community and inclusive social events. Perks : Discounted gym memberships, bike-to-work scheme, and shopping discounts. Subsidised on-site restaurant and social spaces for team interaction. Development & Recognition : Comprehensive training, mentoring, and a pay structure based on skills and experience.

Job Title: Senior Engineering Manager - Nuclear Substantiation Location: Barrow-in-Furness - Hybrid Salary: Competitive What you'll be doing: Management of the production and review of Safety Case Documentation including: Nuclear Substantiation Documentation (summary reports, engineering schedules, bridging documents and safety management documents) for all site Nuclear facilities, & Radiological Substantiation Documentation Peer review of Safety Case Documentation, including; Site Safety Cases, SCAFs (Safety Case Amendment Forms), Hazard reports, Reliability assessments, Hazard Analysis reports and Other supporting documents Intelligent customer review of 3 rd party produced substantiation Presenting updates/outputs to Nuclear Safety Committees for review and approval Team management of approx. 10 members with daily programme management and planning Supporting the Periodic Review of Safety, through Subject Matter Expert (SME) review and implementation of actions/improvements Your skills and experiences: Essential: Technical report writing Experience working in a high hazard industry (nuclear, rail, oil and gas, aerospace, automotive, or other regulated high hazard industry) Document planning & people management experience Desirable: Nuclear safety case or substantiation experience Stakeholder management experience Benefits: You'll receive benefits including a competitive pension scheme, enhanced annual leave allowance and a Company contributed Share Incentive Plan. You'll also have access to additional benefits such as flexible working, an employee assistance programme, Cycle2work and employee discounts - you may also be eligible for an annual incentive The Nuclear substantiation Team: You will be joining an ever-expanding team with some great development opportunities both in the technical and managerial streams. Native to the team, there are opportunities to get involved in the design substantiation and safety justification of a variety of assets and facilities spanning mechanical, civil & structural, and electrical, in addition to getting involved in Finite Element Analysis (FEA) and simulation using the latest cutting-edge tools and techniques. This also involves regular interaction and joint working with the Engineering Authority, Site Specialist Engineers, Site Safety Case, Human Factors, as well as Boat Services and Boat Build functions delivering an exceptionally varied and diverse scope. This interaction offers plenty of development opportunities both in terms of stretch objectives and informal extended collaboration to suite you and your career aspirations. Whether you are an experienced Engineering Manager or an aspiring Principal Engineer, there could be an exciting and fulfilling opportunity waiting for you at the Nuclear Substantiation team - SEA (DDC) at BAE Systems. Apply today to see how far you can go. We offer relocation support packages across all Submarine roles, subject to meeting eligibility criteria. Why BAE Systems? This is a place where you'll be able to make a real difference. You'll be part of an inclusive culture that values diversity of thought, rewards integrity, and merit, and where you'll be empowered to fulfil your potential. We welcome people from all backgrounds and want to make sure that our recruitment processes are as inclusive as possible. If you have a disability or health condition (for example dyslexia, autism, an anxiety disorder etc.) that may affect your performance in certain assessment types, please speak to your recruiter about potential reasonable adjustments. Please be aware that many roles at BAE Systems are subject to both security and export control restrictions. These restrictions mean that factors such as your nationality, any nationalities you may have previously held, and your place of birth can restrict the roles you are eligible to perform within the organisation. All applicants must as a minimum achieve Baseline Personnel Security Standard. Many roles also require higher levels of National Security Vetting where applicants must typically have 5 to 10 years of continuous residency in the UK depending on the vetting level required for the role, to allow for meaningful security vetting checks. Closing Date: 27th June 2025 We reserve the right to close this vacancy early if we receive sufficient applications for the role. Therefore, if you are interested, please submit your application as early as possible.

Title: Senior Validation Specialist Location: Slough Visa and Relocation support is offered with this role. Today, Lonza is a global leader in life sciences operating across five continents. While we work in science, there's no magic formula to how we do it. Our greatest scientific solution is talented people working together, devising ideas that help businesses to help people. In exchange, we let our people own their careers. Their ideas, big and small, genuinely improve the world. And that's the kind of work we want to be part of. The role: The Senior Validation Specialist at Lonza is responsible for working with the Head of Validation in defining the vision and strategy for the Commissioning, Qualification, and Validation (CQV) department. You will be working with colleagues and internal customers sharing knowledge and experience, in all technical areas and aspects of project work throughout the validation lifecycle and determining innovation and identifying compliance requirements in the validation lifecycle Be a technical Subject Matter Expert for at least one area of competency (CSE, Sterilisation, Gas Testing, Clean Room, Equipment Qualification)! Key responsibilities: Cultivate positive relationships between QA, Manufacturing, Quality Control, Development Services, Project Management, business services, and maintenance departments. Support and successfully implement a risk-based approach to CQV. Drive updates to policies & procedures in line with current regulations and industry standards, continuously challenging and improving working practices and performance. Provide support and input for site projects and initiatives, ensuring that the CQV team is aligned. Manage changes aligned with business objectives and support the CQV Team through change to ensure positive outcomes. Troubleshoot technical issues to guarantee smooth operations. Contribute towards supporting Deviation, CAPA, Out Of Specification (OOS), and Out Of Trend (OOT) investigations. Key requirements: BSc/MSc or equivalent experience in Mechanical Engineering, Chemical Engineering, Electronic/Electrical Engineering, Automation, Biological Sciences, or Chemistry. Be a technical Subject Matter Expert for at least one area of competency (CSE, Sterilisation, Gas Testing, Clean Room, Equipment Qualification) Proven knowledge of Regulatory and cGMP guidelines, contributing to quality records (Deviations, Investigations, CAPA, and Change Control). Proactively seeks to understand internal/external customer and market needs. Develops insights that can be used to improve customer happiness and other important measurements. Employs meticulous methods to track and analyse customer performance indicators for continuous improvement. Every day, Lonza's products and services have a positive impact on millions of people. For us, this is not only a great privilege, but also a great responsibility. How we achieve our business results is just as important as the achievements themselves. At Lonza, we respect and protect our people and our environment. Any success we achieve is no success at all if not achieved ethically. People come to Lonza for the challenge and creativity of solving complex problems and developing new ideas in life sciences. In return, we offer the satisfaction that comes with improving lives all around the world. The satisfaction that comes with making a meaningful difference.

Job Title: Senior Engineering Manager - Nuclear Substantiation Location: Barrow-in-Furness - Hybrid Salary: Competitive What you'll be doing: Management of the production and review of Safety Case Documentation including: Nuclear Substantiation Documentation (summary reports, engineering schedules, bridging documents and safety management documents) for all site Nuclear facilities, & Radiological Substantiation Documentation Peer review of Safety Case Documentation, including; Site Safety Cases, SCAFs (Safety Case Amendment Forms), Hazard reports, Reliability assessments, Hazard Analysis reports and Other supporting documents Intelligent customer review of 3 rd party produced substantiation Presenting updates/outputs to Nuclear Safety Committees for review and approval Team management of approx. 10 members with daily programme management and planning Supporting the Periodic Review of Safety, through Subject Matter Expert (SME) review and implementation of actions/improvements Your skills and experiences: Essential: Technical report writing Experience working in a high hazard industry (nuclear, rail, oil and gas, aerospace, automotive, or other regulated high hazard industry) Document planning & people management experience Desirable: Nuclear safety case or substantiation experience Stakeholder management experience Benefits: You'll receive benefits including a competitive pension scheme, enhanced annual leave allowance and a Company contributed Share Incentive Plan. You'll also have access to additional benefits such as flexible working, an employee assistance programme, Cycle2work and employee discounts - you may also be eligible for an annual incentive The Nuclear substantiation Team: You will be joining an ever-expanding team with some great development opportunities both in the technical and managerial streams. Native to the team, there are opportunities to get involved in the design substantiation and safety justification of a variety of assets and facilities spanning mechanical, civil & structural, and electrical, in addition to getting involved in Finite Element Analysis (FEA) and simulation using the latest cutting-edge tools and techniques. This also involves regular interaction and joint working with the Engineering Authority, Site Specialist Engineers, Site Safety Case, Human Factors, as well as Boat Services and Boat Build functions delivering an exceptionally varied and diverse scope. This interaction offers plenty of development opportunities both in terms of stretch objectives and informal extended collaboration to suite you and your career aspirations. Whether you are an experienced Engineering Manager or an aspiring Principal Engineer, there could be an exciting and fulfilling opportunity waiting for you at the Nuclear Substantiation team - SEA (DDC) at BAE Systems. Apply today to see how far you can go. We offer relocation support packages across all Submarine roles, subject to meeting eligibility criteria. Why BAE Systems? This is a place where you'll be able to make a real difference. You'll be part of an inclusive culture that values diversity of thought, rewards integrity, and merit, and where you'll be empowered to fulfil your potential. We welcome people from all backgrounds and want to make sure that our recruitment processes are as inclusive as possible. If you have a disability or health condition (for example dyslexia, autism, an anxiety disorder etc.) that may affect your performance in certain assessment types, please speak to your recruiter about potential reasonable adjustments. Please be aware that many roles at BAE Systems are subject to both security and export control restrictions. These restrictions mean that factors such as your nationality, any nationalities you may have previously held, and your place of birth can restrict the roles you are eligible to perform within the organisation. All applicants must as a minimum achieve Baseline Personnel Security Standard. Many roles also require higher levels of National Security Vetting where applicants must typically have 5 to 10 years of continuous residency in the UK depending on the vetting level required for the role, to allow for meaningful security vetting checks. Closing Date: 27th June 2025 We reserve the right to close this vacancy early if we receive sufficient applications for the role. Therefore, if you are interested, please submit your application as early as possible.

Plumber / Gas Engineer Job Type: Permanent Location: Northeast Annual Salary: Qualified (NVQ L3 + Domestic Gas) Up to 38,000 Qualified (NVQ L3 + Domestic + Commercial Gas) 40,000+ Qualified (NVQ L3 + Domestic + Commercial Gas + OFTEC) 41,000+ Our client is seeking experienced and qualified Plumber / Gas Engineers to join their growing team. The successful candidate will be comfortable working in high-security environments and possess a proactive approach to maintenance and problem-solving, with a specific focus on gas safety and plumbing systems. Day-to-day of the role: Conduct routine maintenance and emergency repairs of plumbing and gas systems. Install, repair, and maintain gas pipes, valves, fittings, drainage systems, and fixtures in commercial and residential structures. Respond to, diagnose, and resolve plumbing and gas emergencies. Perform inspections of plumbing and gas systems to identify and replace worn parts. Ensure compliance with current health and safety standards. Required Skills & Qualifications: NVQ Level 3 Plumbing qualification. Gas safe registered is highly desirable. Experience working in varied environments, including high-security areas. Strong problem-solving and communication skills. Ability to work independently and as part of a team. Benefits: Sign-on bonus. Company van and fuel card provided. Supportive team environment. Annual salary review. To apply for this Plumber / Gas Engineer position, please submit your CV detailing your relevant experience and qualifications.

Postdoctoral Fellow - Hill lab Reporting to: Caroline Hill, Head of Developmental Signalling Laboratory Contact term: This is a full-time, fixed term 4 years position on Crick terms and conditions of employment. About Us The Francis Crick Institute is Europe's largest biomedical research institute under one roof. Our world-class scientists and staff collaborate on vital research to help prevent, diagnose and treat illnesses such as cancer, heart disease, infectious diseases and neurodegenerative conditions. The Crick is a place for collaboration, innovation and exploration across many disciplines. A space where the brightest minds can pursue big and bold ideas and discover answers to crucial scientific questions. We support them in a dynamic environment which fosters excellence with state-of-the-art infrastructure, cutting-edge facilities, and a creative and curious culture. We've removed traditional boundaries of departments, divisions and disciplines and instead have an open approach that supports every researcher. This gives us the freedom to collaborate and carry out high-quality, pioneering research. Creating a space for discovery without boundaries helps us to turn our science into benefits for human health and the economy. The Research Group The Developmental Signalling Laboratory headed by Caroline Hill focuses on cell signalling in early vertebrate development and disease - see . Their work seeks to understand how TGF-b family signalling pathways function normally in early vertebrate development and in adult untransformed cells, and how these signalling pathways are perturbed in disease, in particular in cancer and the Marfan-related syndromes. Work in the Hill laboratory exploits the very powerful combination of early vertebrate developmental systems (zebrafish embryos), together with a variety of model tissue culture systems (human and mouse ES cell/iPS cell models), and mouse cancer models and uses a very wide range of methodologies including developmental and cell biology, cancer biology, next generation sequencing and computational modelling. The Hill lab encourages creative and independent thinking and promotes excellent training and mentoring. The group currently comprises ten people - five postdocs, two PhD students, a clinical fellow, a master's student and a senior laboratory research scientist. For selected recent publications see: The Project Recent work in my lab has determined that mesoderm and endoderm specification in zebrafish embryos requires the interplay of two signalling pathways, Nodal and Fgf/Erk. We have shown that the distribution of endodermal progenitors results from a stochastic process where sustained Nodal signalling provides a competency window for the switching of bipotential progenitors to an endodermal fate. Switching is apparently stochastic and is inhibited by Fgf/Erk signalling. Cells that do not switch to the endodermal fate, differentiate to mesoderm. Thus, we hypothesise that short windows of Erk inactivity govern the switching to the endodermal fate and we have shown that these occur as cells undergo mitosis as a result of a phenomenon we are calling mitotic erasure. We now want to understand whether a similar mechanism controls the cell fate decision between mesoderm and definitive endoderm in humans, and if not, how this fate decision is controlled. To undertake this work, I am looking for a highly motivated postdoc with proven research abilities and an excellent publication record. The project will make use of human embryonic stem cells (hESCs) differentiated as 2D and 3D gastruloids. We will multiplex our novel Erk biosensor with live cell fate reporters to discover whether and how Erk signalling is involved in the cell fate decision between definitive endoderm and mesoderm. Furthermore, we will use multiomics scRNA-seq and scATAC-seq methodology, as well as whole genome CRISPR screening approaches to gain unbiased new insights into the mechanisms driving the specification of the mesodermal and endodermal lineages in humans. Postdoctoral Fellows at the Crick lead their own projects, contribute to other projects on a collaborative basis (both in the lab and with external collaborators) and may guide PhD students in their research. The ability to work in a team is essential. Key experience and competencies The post holder should embody and demonstrate our core Crick values: Bold; Imaginative; Open; Dynamic; Collegial Essential PhD in a relevant biological science Excellent knowledge and demonstrable practical experience of working with embryonic stem cells Extensive technical expertise in differentiating embryonic stem cells to different tissue types as 2D and 3D gastruloids Technical expertise in advanced live imaging Technical expertise in molecular biology Excellent track record of writing papers as evidenced by publications or submitted manuscripts in referred journals Evidence of data presentation at scientific meetings as talks and posters Strong organisational skills and thorough record-keeping Ability to work independently and also in a team Desirable Experience in 'omics techniques and bioinformatic analysis Experience in signal transduction research About Working at the Crick Our values Everyone who works at the Crick has a valuable role to play in advancing the Crick's mission and shaping our culture! We are bold. We make space for creative, dynamic and imaginative ideas and approaches. We're not afraid to do things differently. We are open. We're highly collaborative and interactive, and make sure our activities are visible to the outside world. We are collegial. We show respect for one another, work cooperatively and support the wider community. At the Francis Crick Institute, we believe that diversity and inclusion are essential to driving innovation and scientific discovery. We are committed to creating a workplace where everyone feels valued, respected, and empowered to succeed, regardless of their background, identity, or personal circumstances. We actively encourage applications from individuals of all genders, ethnicities, abilities, and experiences. We want to ensure that everyone can apply and be part of our team and you will be asked as part of the process if you wish to apply under the Disability Confident scheme. We will make reasonable adjustments if you need them. If you need assistance with applying (i.e., would like to apply by phone or post) please email: To find out more about life at the Crick click here . What will you receive? At the Francis Crick Institute, we value our team members and are proud to offer an extensive range of benefits to support their well-being and development: Visas: Applicants for this role will be eligible for sponsorship to work in the UK Generous Leave: 28 days of annual leave, plus three additional days over Christmas and bank holidays. Pension Scheme: Defined contribution pension with employer contributions of up to 16%. Health & Well-being: 24/7 GP consultation services. Occupational health services and mental health support programs. Eye care vouchers and discounted healthcare plans. Work-Life Balance: Back-up care for dependents. Childcare support allowance. Annual leave purchase options. Crick Networks offering diverse groups' support, community and inclusive social events. Perks: Discounted gym memberships, bike-to-work scheme, and shopping discounts. Subsidised on-site restaurant and social spaces for team interaction. Development & Recognition: Comprehensive training, mentoring, and a pay structure based on skills and experience.

We are looking for a Gas Engineer to work in social housing properties in Corby and surrounding areas. This is an ongoing contract role and a van and fuel card will be provided. The successful Gas Engineer will be expected to carry out installs in tenanted properties. The Gas Engineer will receive: 26.50 per hour Van and fuel card Ongoing contract The Gas Engineer successful will be expected to complete: Boiler installs and swaps Work in tenanted social housing properties Monday - Friday, 37 hours per week We are really keen in speaking to any Gas Engineer with: Gas Safe registered Domestic ACS Social housing experience If you feel that this position could be for you in or if you want to know about other roles available, apply here or call Aaron on (phone number removed).

Area Sales Manager Civil Engineering and Groundwork Products Job Title: Technical Sales Manager Civil Engineering and Groundwork products Construction Sector: Structural waterproofing & gas protection systems, main contractors, brickwork contractors, framework contractors, structural engineers, design & build contractors, private developer house builders, groundworkers, civil engineering contractors and Infrastructure contractors Area to be covered: Central & Anglia (Ideally based south of Birmingham/ Northampton area) Remuneration: DOE. + 25% Bonus Benefits: Hybrid car or EV or car allowance & full flexible benefits The role of the Area Sales Manager Civil Engineering and Groundwork will involve: Field sales position, selling our clients a large portfolio of specialist building materials (2000+ specialist products) which includes their own established company branded waterproofing & gas membrane systems. Driving up revenue from Essex based depot, acting as the dedicated field sales representative Selling to various contractors; changing and breaking specifications Typical customers include; main contractors, framework contractors, civil engineers, structural engineers, design and build contractors, private developer house builders, groundworkers, civil engineering contractors and infrastructure contractors Managing approximately 391 accounts with a budget of £3.5 million Growing awareness of our clients brand and pointing customers in the direction of the depot Typically 10 well qualified appointments per week either virtually or face to face You will be able to utilise the ABI lead generation software, as well as existing customers to develop the company customer base Reporting to the Sales Director, you will be expected to manage your own diary Typical projects within the commercial, housing (private developments), civil engineering, transportation and Infrastructure The ideal applicant will be an Area Sales Manager Civil Engineering and Groundwork with: Proven track record in construction field sales Must have sold to contractors Contacts within main contractors, framework contractors, civil engineers, structural engineers, design and build contractors, private developer house builders, groundworkers, civil engineering contractors or infrastructure contractors may be advantageous Open to builders merchant or building products manufacturer field sales backgrounds Autonomous and comfortable with construction site work / site visits New business hunter, with an ability to knock on doors with passion/ enthusiasm Preferably on the up in career, looking for progression Ability to work under own initiative, highly motivated, conscientious, pro-active and organised approach All technical and structural building product backgrounds will be considered The Company: Est. 20 years+ Circa 60 employees £20m+ turnover Part of a larger group Mitchell Maguire is a specialist construction field sales recruitment consultancy, dealing exclusively with construction field sales jobs, construction field sales vacancies and specification field sales positions within: main contractors, brickwork contractors, framework contractors, ground workers, roof refurbishment, roofing, waterproofing, single ply, waterproof membranes, bitumen membranes, civil engineering, structural waterproofing, liquid applied systems, green roofs, concrete repair, damp proofing membranes, building chemicals, specialist sealants, foams & fillers, coatings, sheet waterproofing and structural drainage systems

Area Sales Manager Civil Engineering and Groundwork Products Job Title: Technical Sales Manager Civil Engineering and Groundwork products Construction Sector: Structural waterproofing & gas protection systems, main contractors, brickwork contractors, framework contractors, structural engineers, design & build contractors, private developer house builders, groundworkers, civil engineering contractors and Infrastructure contractors Area to be covered: Central & Anglia (Ideally based south of Birmingham/ Northampton area) Remuneration: DOE. + 25% Bonus Benefits: Hybrid car or EV or car allowance & full flexible benefits The role of the Area Sales Manager Civil Engineering and Groundwork will involve: Field sales position, selling our clients a large portfolio of specialist building materials (2000+ specialist products) which includes their own established company branded waterproofing & gas membrane systems. Driving up revenue from Essex based depot, acting as the dedicated field sales representative Selling to various contractors; changing and breaking specifications Typical customers include; main contractors, framework contractors, civil engineers, structural engineers, design and build contractors, private developer house builders, groundworkers, civil engineering contractors and infrastructure contractors Managing approximately 391 accounts with a budget of £3.5 million Growing awareness of our clients brand and pointing customers in the direction of the depot Typically 10 well qualified appointments per week either virtually or face to face You will be able to utilise the ABI lead generation software, as well as existing customers to develop the company customer base Reporting to the Sales Director, you will be expected to manage your own diary Typical projects within the commercial, housing (private developments), civil engineering, transportation and Infrastructure The ideal applicant will be an Area Sales Manager Civil Engineering and Groundwork with: Proven track record in construction field sales Must have sold to contractors Contacts within main contractors, framework contractors, civil engineers, structural engineers, design and build contractors, private developer house builders, groundworkers, civil engineering contractors or infrastructure contractors may be advantageous Open to builders merchant or building products manufacturer field sales backgrounds Autonomous and comfortable with construction site work / site visits New business hunter, with an ability to knock on doors with passion/ enthusiasm Preferably on the up in career, looking for progression Ability to work under own initiative, highly motivated, conscientious, pro-active and organised approach All technical and structural building product backgrounds will be considered The Company: Est. 20 years+ Circa 60 employees £20m+ turnover Part of a larger group Mitchell Maguire is a specialist construction field sales recruitment consultancy, dealing exclusively with construction field sales jobs, construction field sales vacancies and specification field sales positions within: main contractors, brickwork contractors, framework contractors, ground workers, roof refurbishment, roofing, waterproofing, single ply, waterproof membranes, bitumen membranes, civil engineering, structural waterproofing, liquid applied systems, green roofs, concrete repair, damp proofing membranes, building chemicals, specialist sealants, foams & fillers, coatings, sheet waterproofing and structural drainage systems