WISE Campaign
Stevenage, Hertfordshire
Overview As a Principal Scientist in the Translational Unit, working in Neurodegeneration or Renal Disease, you will play a critical role in bridging preclinical and early clinical proof of concept studies by designing and performing translational assays in human-derived cells, tissues, and biofluids. This is a lab-based position with mandatory on-site presence at either the Upper Providence, Pennsylvania (USA) or Stevenage (UK) laboratory sites. This role will provide YOU the opportunity to lead key activities to progress YOUR career, these responsibilities include some of the following Design and execute laboratory experiments to advance scientific understanding and support drug discovery in neurodegeneration or renal disease. Support identification and validation of clinical biomarkers and development of clinically deployable biomarker assays. Apply expertise in multiple capabilities such as ELISA/MSD/Quanterix, Western/JESS, flow cytometry, gene/protein expression analysis, proteomics, and other omics platforms. Troubleshoot assays effectively and develop alternative approaches when necessary, working closely with preclinical statistics and other relevant teams to ensure robust study design. Maintain accurate and detailed laboratory records in alignment with data integrity expectations and ensure compliance with all relevant protocols and safety guidelines. Why you? Basic Qualifications PhD in a scientific discipline (e.g., Molecular Biology, Genetics, Immunology, or related field) with relevant laboratory experience. 4+ years' experience in translational and biomarker development. Experience with handling of primary human cells and laboratory techniques such as immunoassays (ELISA, MSD, Quanterix), multi-color flow cytometry, and gene expression analysis. Experience in renal disease or neurodegeneration disease areas. Preferred Qualifications Excellent problem-solving skills and ability to critically analyze scientific data. Strong written and verbal communication skills, with the ability to effectively present scientific findings to multidisciplinary internal and external stakeholders in a balanced, clear, and precise manner. Proven ability to balance priorities across multiple objectives, meeting timelines while maintaining attention to detail and high-performance standards. Able to independently define strategic approach to tackle specific project or department goals. Ability to work independently as well as collaboratively in a team-oriented environment. Resourcefulness to access cutting-edge technologies, tools, reagents, biosamples, biomarker expertise, and research capabilities. Please visit GSK US Benefits Summary to learn more about the comprehensive benefits program GSK offers US employees. Why GSK? Uniting science, technology and talent to get ahead of disease together. GSK is a global biopharma company with a purpose to unite science, technology and talent to get ahead of disease together. We aim to positively impact the health of 2.5 billion people by the end of the decade, as a successful, growing company where people can thrive. We get ahead of disease by preventing and treating it with innovation in specialty medicines and vaccines. We focus on four therapeutic areas: respiratory, immunology and inflammation; oncology; HIV; and infectious diseases - to impact health at scale. People and patients around the world count on the medicines and vaccines we make, so we're committed to creating an environment where our people can thrive and focus on what matters most. Our culture of being ambitious for patients, accountable for impact and doing the right thing is the foundation for how, together, we deliver for patients, shareholders and our people. If you require an accommodation or other assistance to apply for a job at GSK, please contact the GSK Service Centre at 1- (US Toll Free) or +1 (outside US). GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law. Important notice to Employment businesses/ Agencies GSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK's commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site. Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSK's compliance to all federal and state US Transparency requirements. For more information, please visit the Centers for Medicare and Medicaid Services (CMS) website at
Overview As a Principal Scientist in the Translational Unit, working in Neurodegeneration or Renal Disease, you will play a critical role in bridging preclinical and early clinical proof of concept studies by designing and performing translational assays in human-derived cells, tissues, and biofluids. This is a lab-based position with mandatory on-site presence at either the Upper Providence, Pennsylvania (USA) or Stevenage (UK) laboratory sites. This role will provide YOU the opportunity to lead key activities to progress YOUR career, these responsibilities include some of the following Design and execute laboratory experiments to advance scientific understanding and support drug discovery in neurodegeneration or renal disease. Support identification and validation of clinical biomarkers and development of clinically deployable biomarker assays. Apply expertise in multiple capabilities such as ELISA/MSD/Quanterix, Western/JESS, flow cytometry, gene/protein expression analysis, proteomics, and other omics platforms. Troubleshoot assays effectively and develop alternative approaches when necessary, working closely with preclinical statistics and other relevant teams to ensure robust study design. Maintain accurate and detailed laboratory records in alignment with data integrity expectations and ensure compliance with all relevant protocols and safety guidelines. Why you? Basic Qualifications PhD in a scientific discipline (e.g., Molecular Biology, Genetics, Immunology, or related field) with relevant laboratory experience. 4+ years' experience in translational and biomarker development. Experience with handling of primary human cells and laboratory techniques such as immunoassays (ELISA, MSD, Quanterix), multi-color flow cytometry, and gene expression analysis. Experience in renal disease or neurodegeneration disease areas. Preferred Qualifications Excellent problem-solving skills and ability to critically analyze scientific data. Strong written and verbal communication skills, with the ability to effectively present scientific findings to multidisciplinary internal and external stakeholders in a balanced, clear, and precise manner. Proven ability to balance priorities across multiple objectives, meeting timelines while maintaining attention to detail and high-performance standards. Able to independently define strategic approach to tackle specific project or department goals. Ability to work independently as well as collaboratively in a team-oriented environment. Resourcefulness to access cutting-edge technologies, tools, reagents, biosamples, biomarker expertise, and research capabilities. Please visit GSK US Benefits Summary to learn more about the comprehensive benefits program GSK offers US employees. Why GSK? Uniting science, technology and talent to get ahead of disease together. GSK is a global biopharma company with a purpose to unite science, technology and talent to get ahead of disease together. We aim to positively impact the health of 2.5 billion people by the end of the decade, as a successful, growing company where people can thrive. We get ahead of disease by preventing and treating it with innovation in specialty medicines and vaccines. We focus on four therapeutic areas: respiratory, immunology and inflammation; oncology; HIV; and infectious diseases - to impact health at scale. People and patients around the world count on the medicines and vaccines we make, so we're committed to creating an environment where our people can thrive and focus on what matters most. Our culture of being ambitious for patients, accountable for impact and doing the right thing is the foundation for how, together, we deliver for patients, shareholders and our people. If you require an accommodation or other assistance to apply for a job at GSK, please contact the GSK Service Centre at 1- (US Toll Free) or +1 (outside US). GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law. Important notice to Employment businesses/ Agencies GSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK's commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site. Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSK's compliance to all federal and state US Transparency requirements. For more information, please visit the Centers for Medicare and Medicaid Services (CMS) website at
WISE Campaign
Job description Site Name: Belgium-Wavre, GSK HQ, Warsaw Posted Date: Nov About the role Provides medical/scientific knowledge in the safety evaluation and risk management of GSK products in clinical development and/or the post-marketing setting. Ensures scientifically sound review and interpretation of data and management of safety issues and escalates safety issues identified through the safety review process to senior management and safety governance as appropriate. Makes recommendations for the further characterization, management, and communication of safety risks. Focus on efficiency and effectiveness to meet the needs of our Patients and HCPs. Supporting the pharmacovigilance and benefit-risk management of the assigned portfolio of GSK global assets to ensure Patient Safety globally. If appointed as a manager (i.e., Team/Group Leader) is responsible for leadership of a team of individual contributors. Line Management (including functional matrix reports) leadership competencies include resource and team management, coaching, influencing others, collaborative working, decision making, change management, partnership, and relations management. Scope of accountability: Safety signal detection, assessment, and risk management. May chair Safety Review Team. About the responsibilities 1. Scientific/Medical Knowledge PV Expertise Responsible for signal detection and evaluation activities for assigned products. Ensures that accurate and fit-for-purpose evaluation documents with clear conclusions are provided in response to internal or regulatory authority requests for safety data. Assists in the production of Risk Management Plans (RMPs)/Risk Tables for designated products, in consultation with senior personnel. Authors regulatory periodic reports and associated documentation globally according to the agreed process and timelines - reviews and contributes to production of program documents such as protocols and aggregate safety reports. Acts as a member of a process improvement initiative team within GCSP. Completes any post audit/inspection activities within the required timeline Uses a range of sources and methods to gather information, identifies and proposes potential solutions for addressing issues/problems, and makes decisions with consultation of SERM physician. Shows commitment to the task and effective time management to meet multiple deadlines successfully and with attention to detail and quality. Able to prioritise own workload with minimal guidance. 2. Cross-functional Matrix team leadership Builds effective working relationships and responds to the needs of line functions in the matrix in relation to safety issues. Supports safety governance/SRTs in the clinical development and post marketing settings by assisting in the establishment and operation of cross-functional teams in any SERM to detect and address product safety issues and ensures that risk-reduction strategies are implemented appropriately in clinical study protocols and/or product labelling. Mentors junior SERM colleagues, can contribute to evaluating the activities of junior colleagues. Can explain knowledge and skills, and work in new situations. Early capability for Safety Lead role. 3. Communications (verbal, written) and Influencing (internal PV Governance and External LTs) Shares ideas with line manager on ways to improve processes for assigned tasks. Is able and willing to adjust behaviors and priorities based on changing environment. Is able to deal with ambiguity and resilient, focused, and optimistic under pressure. Shows effectiveness in both oral and written communication. Able to effectively express ideas and incorporate feedback into deliverables to create a quality output. Holds thorough medical/scientific writing skills, as the preparation of detailed evaluations and reports is a core feature of the role. Supports a safety risk positions Keeps manager/supervisor informed of progress and activities; escalates issues as appropriate. Is Able to present merits of own point of view. About you Basic requirement Health Sciences/Health Care Professional degree required (e.g., BSc, MS, PhD, RN/BSN/MSN, NP, RPh/B Pharm/Pharm D). Advanced degree preferred. Preferred requirements Pharmacovigilance experience relating to Safety Evaluation and Risk Management, encompassing both clinical development and post-marketing activities Knowledge/experience of international pharmacovigilance requirements (e.g., ICH, GVP modules, CIOMS initiatives) and drug development and approval processes. Experience working in large matrix organizations If you have a disability and require assistance during the course of the selection process, you will have the opportunity to let us know what specific assistance you require in order to make suitable arrangements. Why GSK? Uniting science, technology and talent to get ahead of disease together. GSK is a global biopharma company with a purpose to unite science, technology and talent to get ahead of disease together. We aim to positively impact the health of 2.5 billion people by the end of the decade, as a successful, growing company where people can thrive. We get ahead of disease by preventing and treating it with innovation in specialty medicines and vaccines. We focus on four therapeutic areas: respiratory, immunology and inflammation; oncology; HIV; and infectious diseases to impact health at scale. People and patients around the world count on the medicines and vaccines we make, so we're committed to creating an environment where our people can thrive and focus on what matters most. Our culture of being ambitious for patients, accountable for impact and doing the right thing is the foundation for how, together, we deliver for patients, shareholders and our people.
Job description Site Name: Belgium-Wavre, GSK HQ, Warsaw Posted Date: Nov About the role Provides medical/scientific knowledge in the safety evaluation and risk management of GSK products in clinical development and/or the post-marketing setting. Ensures scientifically sound review and interpretation of data and management of safety issues and escalates safety issues identified through the safety review process to senior management and safety governance as appropriate. Makes recommendations for the further characterization, management, and communication of safety risks. Focus on efficiency and effectiveness to meet the needs of our Patients and HCPs. Supporting the pharmacovigilance and benefit-risk management of the assigned portfolio of GSK global assets to ensure Patient Safety globally. If appointed as a manager (i.e., Team/Group Leader) is responsible for leadership of a team of individual contributors. Line Management (including functional matrix reports) leadership competencies include resource and team management, coaching, influencing others, collaborative working, decision making, change management, partnership, and relations management. Scope of accountability: Safety signal detection, assessment, and risk management. May chair Safety Review Team. About the responsibilities 1. Scientific/Medical Knowledge PV Expertise Responsible for signal detection and evaluation activities for assigned products. Ensures that accurate and fit-for-purpose evaluation documents with clear conclusions are provided in response to internal or regulatory authority requests for safety data. Assists in the production of Risk Management Plans (RMPs)/Risk Tables for designated products, in consultation with senior personnel. Authors regulatory periodic reports and associated documentation globally according to the agreed process and timelines - reviews and contributes to production of program documents such as protocols and aggregate safety reports. Acts as a member of a process improvement initiative team within GCSP. Completes any post audit/inspection activities within the required timeline Uses a range of sources and methods to gather information, identifies and proposes potential solutions for addressing issues/problems, and makes decisions with consultation of SERM physician. Shows commitment to the task and effective time management to meet multiple deadlines successfully and with attention to detail and quality. Able to prioritise own workload with minimal guidance. 2. Cross-functional Matrix team leadership Builds effective working relationships and responds to the needs of line functions in the matrix in relation to safety issues. Supports safety governance/SRTs in the clinical development and post marketing settings by assisting in the establishment and operation of cross-functional teams in any SERM to detect and address product safety issues and ensures that risk-reduction strategies are implemented appropriately in clinical study protocols and/or product labelling. Mentors junior SERM colleagues, can contribute to evaluating the activities of junior colleagues. Can explain knowledge and skills, and work in new situations. Early capability for Safety Lead role. 3. Communications (verbal, written) and Influencing (internal PV Governance and External LTs) Shares ideas with line manager on ways to improve processes for assigned tasks. Is able and willing to adjust behaviors and priorities based on changing environment. Is able to deal with ambiguity and resilient, focused, and optimistic under pressure. Shows effectiveness in both oral and written communication. Able to effectively express ideas and incorporate feedback into deliverables to create a quality output. Holds thorough medical/scientific writing skills, as the preparation of detailed evaluations and reports is a core feature of the role. Supports a safety risk positions Keeps manager/supervisor informed of progress and activities; escalates issues as appropriate. Is Able to present merits of own point of view. About you Basic requirement Health Sciences/Health Care Professional degree required (e.g., BSc, MS, PhD, RN/BSN/MSN, NP, RPh/B Pharm/Pharm D). Advanced degree preferred. Preferred requirements Pharmacovigilance experience relating to Safety Evaluation and Risk Management, encompassing both clinical development and post-marketing activities Knowledge/experience of international pharmacovigilance requirements (e.g., ICH, GVP modules, CIOMS initiatives) and drug development and approval processes. Experience working in large matrix organizations If you have a disability and require assistance during the course of the selection process, you will have the opportunity to let us know what specific assistance you require in order to make suitable arrangements. Why GSK? Uniting science, technology and talent to get ahead of disease together. GSK is a global biopharma company with a purpose to unite science, technology and talent to get ahead of disease together. We aim to positively impact the health of 2.5 billion people by the end of the decade, as a successful, growing company where people can thrive. We get ahead of disease by preventing and treating it with innovation in specialty medicines and vaccines. We focus on four therapeutic areas: respiratory, immunology and inflammation; oncology; HIV; and infectious diseases to impact health at scale. People and patients around the world count on the medicines and vaccines we make, so we're committed to creating an environment where our people can thrive and focus on what matters most. Our culture of being ambitious for patients, accountable for impact and doing the right thing is the foundation for how, together, we deliver for patients, shareholders and our people.
