Orchard Therapeutics

Location: London Reporting to: SVP, Head of Human Resources Job Summary Orchard Therapeutics is a global biotechnology gene therapy company dedicated to transforming the lives of people affected by rare diseases through the development of innovative, potentially curative cell and gene therapies. Orchard has its global headquarters in London and is a wholly owned subsidiary of Kyowa Kirin, a Japan-based Global Specialty Pharmaceutical Company. The Senior HR Business Partner (HRBP) is a critical strategic partner to C-level global functional leaders, providing expert advice, coaching and solutions across all aspects of the employee lifecycle. Reporting to the Head of HR, the HRBP will play a key role in shaping and importantly delivering people strategies that enhance organisational performance, capability and culture across a global, matrixed environment. Key Elements and Responsibilities Partner with senior, C-level executive leadership and global functional leaders to provide strategic HR guidance across all aspects of the employee lifecycle, including talent, performance, engagement and organisational effectiveness Build trusted relationships and coach leaders to enhance capability, leadership effectiveness and organisational performance Act as a strategic partner in hiring, working with leaders and Talent Acquisition to define workforce needs, guide selection decisions and ensure high-quality, timely hiring outcomes Drive annual talent management processes, including goal setting, talent and succession reviews, performance management and compensation planning in collaboration with Global Rewards Develop and implement business-aligned HR strategies that support organisational goals, growth and transformation Contribute to the development of the HR function by coaching team members and supporting the Head of HR in building organisational capability Ensure effective utilisation and continuous improvement of HR systems, promoting data accuracy and insight-driven decision making Lead employee relations matters, ensuring appropriate handling, resolution and risk mitigation Monitor external trends and best practices to inform HR strategy and continuous improvement Ensure compliance with applicable employment legislation, policies and procedures Experience, skills and knowledge required Significant global HR generalist experience, ideally within a complex, matrixed, international organisation Proven track record as an HRBP, influencing senior leaders to enhance organisational performance and drive change Strong business acumen, with the ability to influence executive and functional leadership on people-related matters in alignment with business priorities and performance outcomes Strong working knowledge of HR practices and employment frameworks across multiple geographies, with the ability to navigate regional nuances Demonstrated ability to build credible, trusted relationships and operate effectively at all organisational levels Skilled in coaching, influencing and constructively challenging leaders to enhance capability, engagement and performance Ability to translate business strategy into pragmatic, people-focused solutions and actions Strong analytical and problem-solving skills, with the ability to leverage data to inform decision-making Proficient in HR systems and technologies, with a focus on data integrity and continuous process improvement Highly organised with strong attention to detail and the ability to manage competing priorities Excellent communication skills, with the ability to convey complex information clearly and effectively Comfortable operating both strategically and hands-on in a fast-paced, evolving environment Experience within the biotechnology, biopharmaceutical or healthcare industry is preferred Education Bachelor's degree (or equivalent) required, preferably in Human Resources, Business Administration or a related field, with a recognised professional HR qualification (e.g. CIPD or equivalent)

Orchard Therapeutics, a biotechnology gene therapy company, is seeking a Senior HR Business Partner (HRBP) to strategically guide C-level executive leaders. This role involves providing expert HR advice across all employee lifecycle aspects, influencing policies to enhance organisational performance and culture. The ideal candidate will hold a Bachelor's degree and possess significant HRBP experience in complex environments. The position offers a great opportunity to contribute to a fast-paced and evolving company culture in London.

Orchard Therapeutics is searching for a Senior Director of Facilities Engineering based in London. This pivotal role involves leading the design, build, and operational readiness of a new GMP gene therapy manufacturing suite, alongside managing a multidisciplinary team. The ideal candidate will have substantial experience in facilities engineering in GMP environments, with expertise in regulatory compliance and project leadership. Provide strategic oversight for laboratory and corporate operations.

Orchard Therapeutics is looking for a Senior Director of Biostatistics in London/Hybrid to lead its Biostatistics function. This role calls for over 15 years of experience, including management in drug development and regulatory interactions. You will promote statistical innovation, oversee a team, and ensure compliance with regulatory requirements. Ideal candidates will have advanced degrees in statistics and expertise in statistical methodologies. Join a dynamic team dedicated to transforming lives through innovative gene therapies.

Location: London/Hybrid Orchard Therapeutics, a Kyowa Kirin company, is a global gene therapy leader focused on transforming the lives of patients with rare disorders through innovative gene therapies based on gene-modified hematopoietic stem cells (HSCs). Orchard has its global headquarters in London, England. Job Summary The Senior Director, Biostatistics is the head of Orchard's Biostatistics function and a key member of the Medical/Clinical Development team, working to provide transformative gene therapies to patients. This role provides a unique opportunity to contribute strategic statistical thinking to clinical drug development across multiple programs, in a dynamic environment. You will be the primary voice for statistical innovation, ensuring that our gene therapy candidates are evaluated using the most robust and efficient methodologies available. This role requires a blend of deep technical expertise and the presence to interact effectively with both internal stakeholders and global regulatory agencies. The position will report to the VP, Clinical Science and will have management responsibility for a team of statisticians and programmers. Key Responsibilities Team building: Build and lead a high-performing Biostatistics team, promote collaboration and advance professional development. Develop and monitor departmental objectives. Ensure adherence to annual budget targets, including effective oversight of third-party vendors. Strategic leadership: Provide input into clinical development plans to ensure statistical integrity, compliance with regulatory requirements, and alignment with Orchard's objectives. Cross-functional and external collaboration: Partner with clinical, regulatory, and medical affairs colleagues, and with external partners and vendors, to support the clinical development of Orchard's assets. Innovation: Explore and implement novel statistical methodologies where possible, considering specific requirements for gene therapy (one time administration and long-term follow-up) and rare disease/small populations. Regulatory engagement: Represent Orchard as the lead statistician during interactions with global regulatory and health technology agencies. Review/contribute to regulatory briefing documents, defend the statistical integrity of regulatory submissions, and respond to technical questions from agencies. Study design and execution: Provide statistical input as required, including sample size justification, specification of estimands, oversight of SAP/shell production, oversight of vendors, and ensuring correct interpretation of results in study reports and submission documents. Education / Key Competencies 15+ years' experience working as a statistician in drug development including significant interactions with regulatory authorities with at least 5 years in a management role. MSc or PhD in statistics or related discipline. Evidence of strategic input both at the departmental and program level. Excellent communication skills and in particular the ability to communicate complex statistical concepts to non-statisticians. Expertise in a range of statistical methodologies with practical applications (experience with rare diseases, small populations or Bayesian methodology would be an advantage). Prior experience of regulatory interactions, including acting as a lead statistician in regulatory submission(s). Prior experience as project statistician including both design and setup of a program and analysis and reporting. Proficiency with SAS (experience with R is an advantage); good knowledge of CDISC standards. Orchard is an equal opportunity employer. We recognise and celebrate the diverse culture of our workforce and are committed to creating an inclusive environment for our employees. We fully support the principle of Equality and Diversity in employment and oppose all forms of unlawful or unfair discrimination. We assess all applications on basis of job requirements and individual qualifications. We work within the requirements of all current legislation and we implement the provisions of regulatory codes of practice in employment. Notice to All Applicants: Orchard Therapeutics participates in E-Verify