AstraZeneca
Frampton On Severn, Gloucestershire
Job Title: Associate Director - Oncology Targeted Delivery- Safety Science & Discovery Location: Cambridge Salary: Competitive At AstraZeneca, our bold ambition is to eliminate cancer as a cause of death, supported by our rich pipeline aimed at delivering innovative treatment options for patients. Our Oncology Safety colleagues play a crucial role in this mission by accelerating innovative and expert non-clinical safety science. We are seeking an Associate Director, Oncology Safety Science to contribute to the discovery and safety evaluation of novel targeted oncology medicines, primarily focusing on Antibody Drug Conjugates (ADCs) and Radio-conjugates (RCs). Collaborating with scientists across our Oncology R&D organization, you will develop in vitro and in vivo safety strategies to address drug target- and modality-related safety risks, driving the progression of drug discovery programs and influencing the design and selection of novel drug candidates. This role is based in Cambridge, UK, where you will have the opportunity to develop your knowledge and skills alongside experts and leaders in various fields. Accountabilities As a core member of multidisciplinary drug discovery teams, direct discovery toxicology strategies to predict, assess, and mitigate target- and modality-related safety risks, focusing on ADCs and RCs. Design and conduct innovative toxicology studies (in vitro, ex vivo, and in vivo) to predict, assess, and mitigate target- and modality-related safety risks in discovery programs and inform decision-making. Develop and implement innovative safety science solutions and research proposals to advance cutting edge science and technologies in line with business and safety needs. Maintain expertise in preclinical safety strategies for ADCs and RCs, with an awareness of industry trends. Collaborate with cross functional teams within Clinical Pharmacology and Safety Sciences (CPSS) and Oncology R&D to develop and adapt safety screening strategies for advancing drug discovery programs. Publish in high quality, peer reviewed journals, and present at internal scientific meetings and external conferences. Essential Skills/Experience Excellent scientist with a PhD (or equivalent) in Toxicology, Pharmacology, Molecular & Cell Biology, Oncology, Immunology or related field, a strong scientific track record, and a willingness to challenge conventional thinking. Substantial experience in toxicology, drug discovery and development, with a strong track record of independent research in industry, biotech, or academic settings. Strong background in building and validating complex in vitro models for toxicology, delivering decision making data. Expertise in Oncology and targeted therapeutics and awareness of drug safety aspects of ADCs and/or RCs. Experience in designing and executing in vitro and/or in vivo experiments to determine the effects of therapeutics on biological systems. Ability develop testable hypotheses, and drive scientific learning. Collaborative, team oriented approach, with proven problem solving skills focused on goals and the capacity to coordinate tasks across multiple projects. Excellent communication, presentation, interpersonal and influencing skills across levels and subject areas with a strong desire to drive personal development. Desirable Skills/Experience Knowledge in incorporating quantitative systems pharmacology and toxicology (QSP/QST) approaches with in vitro data to predict clinical safety risks is a plus. In vitro imaging expertise (e.g., confocal microscopy, imaging flow cytometry, and other high throughput methods), as well as hands on experience with mAb/ADC internalization assays, are desirable. When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world. AstraZeneca is a place where diverse minds come together united by a shared passion to learn, grow, and discover. Our scientific community seamlessly fuses academia with industry expertise. We celebrate successes while learning from the best. With female leaders holding 45% of senior roles internally and 475 pre clinical collaborations across 26 countries externally, we are committed to expediting research in some of the hardest to treat cancers. Join us to build a meaningful career as part of a team dedicated to improving the lives of millions with cancer. SO, WHAT'S NEXT? We welcome your application no later than 11th of January 2026 Where can I find out more? Follow AstraZeneca on LinkedIn Follow AstraZeneca on Facebook Follow AstraZeneca on Instagram Ready to make a difference? Apply now to join our team! Date Posted 17-Dec-2025 Closing Date 11-Jan-2026 Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.
Job Title: Associate Director - Oncology Targeted Delivery- Safety Science & Discovery Location: Cambridge Salary: Competitive At AstraZeneca, our bold ambition is to eliminate cancer as a cause of death, supported by our rich pipeline aimed at delivering innovative treatment options for patients. Our Oncology Safety colleagues play a crucial role in this mission by accelerating innovative and expert non-clinical safety science. We are seeking an Associate Director, Oncology Safety Science to contribute to the discovery and safety evaluation of novel targeted oncology medicines, primarily focusing on Antibody Drug Conjugates (ADCs) and Radio-conjugates (RCs). Collaborating with scientists across our Oncology R&D organization, you will develop in vitro and in vivo safety strategies to address drug target- and modality-related safety risks, driving the progression of drug discovery programs and influencing the design and selection of novel drug candidates. This role is based in Cambridge, UK, where you will have the opportunity to develop your knowledge and skills alongside experts and leaders in various fields. Accountabilities As a core member of multidisciplinary drug discovery teams, direct discovery toxicology strategies to predict, assess, and mitigate target- and modality-related safety risks, focusing on ADCs and RCs. Design and conduct innovative toxicology studies (in vitro, ex vivo, and in vivo) to predict, assess, and mitigate target- and modality-related safety risks in discovery programs and inform decision-making. Develop and implement innovative safety science solutions and research proposals to advance cutting edge science and technologies in line with business and safety needs. Maintain expertise in preclinical safety strategies for ADCs and RCs, with an awareness of industry trends. Collaborate with cross functional teams within Clinical Pharmacology and Safety Sciences (CPSS) and Oncology R&D to develop and adapt safety screening strategies for advancing drug discovery programs. Publish in high quality, peer reviewed journals, and present at internal scientific meetings and external conferences. Essential Skills/Experience Excellent scientist with a PhD (or equivalent) in Toxicology, Pharmacology, Molecular & Cell Biology, Oncology, Immunology or related field, a strong scientific track record, and a willingness to challenge conventional thinking. Substantial experience in toxicology, drug discovery and development, with a strong track record of independent research in industry, biotech, or academic settings. Strong background in building and validating complex in vitro models for toxicology, delivering decision making data. Expertise in Oncology and targeted therapeutics and awareness of drug safety aspects of ADCs and/or RCs. Experience in designing and executing in vitro and/or in vivo experiments to determine the effects of therapeutics on biological systems. Ability develop testable hypotheses, and drive scientific learning. Collaborative, team oriented approach, with proven problem solving skills focused on goals and the capacity to coordinate tasks across multiple projects. Excellent communication, presentation, interpersonal and influencing skills across levels and subject areas with a strong desire to drive personal development. Desirable Skills/Experience Knowledge in incorporating quantitative systems pharmacology and toxicology (QSP/QST) approaches with in vitro data to predict clinical safety risks is a plus. In vitro imaging expertise (e.g., confocal microscopy, imaging flow cytometry, and other high throughput methods), as well as hands on experience with mAb/ADC internalization assays, are desirable. When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world. AstraZeneca is a place where diverse minds come together united by a shared passion to learn, grow, and discover. Our scientific community seamlessly fuses academia with industry expertise. We celebrate successes while learning from the best. With female leaders holding 45% of senior roles internally and 475 pre clinical collaborations across 26 countries externally, we are committed to expediting research in some of the hardest to treat cancers. Join us to build a meaningful career as part of a team dedicated to improving the lives of millions with cancer. SO, WHAT'S NEXT? We welcome your application no later than 11th of January 2026 Where can I find out more? Follow AstraZeneca on LinkedIn Follow AstraZeneca on Facebook Follow AstraZeneca on Instagram Ready to make a difference? Apply now to join our team! Date Posted 17-Dec-2025 Closing Date 11-Jan-2026 Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.
AstraZeneca
Hackney, London
Medical Solutions Partner (MSP) Location: Field Based - National Are you ready to lead the charge in transforming patient care and access to scientific innovations? You will drive system transformation efforts to improve patient pathways and ensure equitable access to AstraZeneca's scientific breakthroughs. Engaging at a national or regional level, you will act as a Coach, Mentor, and Line Manager for tumor area-aligned Medical Science Liaison (MSL) teams. Your role will integrate advanced scientific expertise, medical system insight, and data-led performance management to optimise standards of care and deliver measurable medical impact. Accountabilities Transforming Care Initiatives In partnership with the Transforming Care Team, provide medical leadership to co-create, and implement Pathway Optimisation initiatives, integrating lasting solutions that improve equity and patient care. Collaborate with colleagues to anticipate unmet needs and advance initiatives that improve patient pathways and access. Cultivate networks focused on scalable Transforming Care initiatives across systems and partners. Strategic Leadership & Territory Ecosystem Lead tumour area field medical strategy, anticipating care gaps and treatment barriers at global, regional, and national levels to optimise standards of care and advance patient outcomes through data-led insights and collaborative territory execution. Manage team performance through ongoing improvement and excellence, by offering mentorship, coaching support, and growth opportunities, encouraging collaboration and motivation. Gathering & Applying Quality Insights Lead all aspects of gathering, analyzing, and sharing impact data on medical activities for tumor field, ensuring data-driven decisions and prioritized resource allocation. Drive a culture of anticipating medical trends, using multiple insight sources for territory planning and performance monitoring. Scientific Exchange, Research Support & Evidence Generation Guide teams to engage in high-impact strategic discussions with external experts, demonstrating deep understanding of AZ portfolio, treatment landscapes, and unmet needs. Lead national and global cancer research projects to improve clinical research impact. Team Leadership & Compliance Act as Coach, Mentor, and Line Manager for tumour area-aligned MSLs, supporting professional growth, development opportunities, and goal alignment. Ensure collaborative working practices, cross-functional integration (Medical, commercial, market access), and high team engagement to optimize organizational impact. Ensure full compliance with the PMCPA Code of Practice across field medical activities, with responsibility for monitoring adherence, delivering training, and upholding exemplary standards in promotional and medical practices. Acts as an AQP / signatory (code review) for head office / field led activities Essential Skills/Experience Relevant degree or equivalent Knowledge of Oncology Medical system architecture Proven capability in PMCPA Code application and compliance training, AQP/Nominated signatory or to be obtained within 9 months of appointment Experience in medical affairs or field-based medical roles, with a strong track record of team and project leadership, coaching/mentoring, and external expert engagement at national or regional level Experience contributing to initiatives devoted to pathway redesign, service integration, digital transformation, or diagnostic innovation Demonstrated strategic planning and agile execution aligned to evolving medical priorities and enterprise-wide objectives Proven experience collecting, analyzing, and communicating field medical impact metrics to influence decision-making Operational excellence in compliance management, including PMCPA application Strong digital literacy for system mapping, engagement planning, and virtual collaboration; excellent cross-functional collaboration skills Desirable Skills/Experience Relevant advanced scientific degree (e.g., PharmD, PhD, MD, MSc) or equivalent Additional training/education in health systems science, health policy, population health, or health system change management Leadership/coaching certifications; digital health or data analytics coursework Experience spearheading projects dedicated to pathway redesign, improving service coordination, and encouraging innovation in the digital and diagnostics areas Prior success in influencing and delivering national/global tumour area studies and evidence generation programmes Experience aligning medical and organizational objectives to improve equity and access across health systems AstraZeneca offers an environment where innovation thrives. Our Oncology area is driving business growth with entrepreneurial thinking. We are committed to redefining cancer treatment by combining science with strategy. Here you will find a supportive culture that empowers you to take charge of your career development while making an impact on patients' lives. Join us in our mission to eliminate cancer as a cause of death. Ready to make a difference? Apply now to become part of our ground-breaking journey! Date Posted: 22-Dec-2025 Closing Date: 18-Jan-2026 Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.
Medical Solutions Partner (MSP) Location: Field Based - National Are you ready to lead the charge in transforming patient care and access to scientific innovations? You will drive system transformation efforts to improve patient pathways and ensure equitable access to AstraZeneca's scientific breakthroughs. Engaging at a national or regional level, you will act as a Coach, Mentor, and Line Manager for tumor area-aligned Medical Science Liaison (MSL) teams. Your role will integrate advanced scientific expertise, medical system insight, and data-led performance management to optimise standards of care and deliver measurable medical impact. Accountabilities Transforming Care Initiatives In partnership with the Transforming Care Team, provide medical leadership to co-create, and implement Pathway Optimisation initiatives, integrating lasting solutions that improve equity and patient care. Collaborate with colleagues to anticipate unmet needs and advance initiatives that improve patient pathways and access. Cultivate networks focused on scalable Transforming Care initiatives across systems and partners. Strategic Leadership & Territory Ecosystem Lead tumour area field medical strategy, anticipating care gaps and treatment barriers at global, regional, and national levels to optimise standards of care and advance patient outcomes through data-led insights and collaborative territory execution. Manage team performance through ongoing improvement and excellence, by offering mentorship, coaching support, and growth opportunities, encouraging collaboration and motivation. Gathering & Applying Quality Insights Lead all aspects of gathering, analyzing, and sharing impact data on medical activities for tumor field, ensuring data-driven decisions and prioritized resource allocation. Drive a culture of anticipating medical trends, using multiple insight sources for territory planning and performance monitoring. Scientific Exchange, Research Support & Evidence Generation Guide teams to engage in high-impact strategic discussions with external experts, demonstrating deep understanding of AZ portfolio, treatment landscapes, and unmet needs. Lead national and global cancer research projects to improve clinical research impact. Team Leadership & Compliance Act as Coach, Mentor, and Line Manager for tumour area-aligned MSLs, supporting professional growth, development opportunities, and goal alignment. Ensure collaborative working practices, cross-functional integration (Medical, commercial, market access), and high team engagement to optimize organizational impact. Ensure full compliance with the PMCPA Code of Practice across field medical activities, with responsibility for monitoring adherence, delivering training, and upholding exemplary standards in promotional and medical practices. Acts as an AQP / signatory (code review) for head office / field led activities Essential Skills/Experience Relevant degree or equivalent Knowledge of Oncology Medical system architecture Proven capability in PMCPA Code application and compliance training, AQP/Nominated signatory or to be obtained within 9 months of appointment Experience in medical affairs or field-based medical roles, with a strong track record of team and project leadership, coaching/mentoring, and external expert engagement at national or regional level Experience contributing to initiatives devoted to pathway redesign, service integration, digital transformation, or diagnostic innovation Demonstrated strategic planning and agile execution aligned to evolving medical priorities and enterprise-wide objectives Proven experience collecting, analyzing, and communicating field medical impact metrics to influence decision-making Operational excellence in compliance management, including PMCPA application Strong digital literacy for system mapping, engagement planning, and virtual collaboration; excellent cross-functional collaboration skills Desirable Skills/Experience Relevant advanced scientific degree (e.g., PharmD, PhD, MD, MSc) or equivalent Additional training/education in health systems science, health policy, population health, or health system change management Leadership/coaching certifications; digital health or data analytics coursework Experience spearheading projects dedicated to pathway redesign, improving service coordination, and encouraging innovation in the digital and diagnostics areas Prior success in influencing and delivering national/global tumour area studies and evidence generation programmes Experience aligning medical and organizational objectives to improve equity and access across health systems AstraZeneca offers an environment where innovation thrives. Our Oncology area is driving business growth with entrepreneurial thinking. We are committed to redefining cancer treatment by combining science with strategy. Here you will find a supportive culture that empowers you to take charge of your career development while making an impact on patients' lives. Join us in our mission to eliminate cancer as a cause of death. Ready to make a difference? Apply now to become part of our ground-breaking journey! Date Posted: 22-Dec-2025 Closing Date: 18-Jan-2026 Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.
