AstraZeneca

4 job(s) at AstraZeneca

AstraZeneca
Aug 25, 2026
Full time
Introduction to role: Are you ready to steer financial strategy that expands patient access and accelerates sustainable growth across the UK and Ireland? This role places you at the heart of decisions that shape launch readiness, pricing, and access-translating insight into action for medicines that change lives. Reporting to the Head of Finance & Commercial Operations, you will serve as the finance lead for a designated disease area with full P&L responsibility across in-line and pipeline assets. Your analysis, modelling and influence will guide cross-functional teams through strategic choices and investment decisions. Can you see yourself turning complex data into clear direction that helps therapies reach under-served patients sooner? You will work closely with Commercial, Medical, Market Access, GFS, Controlling, EUCAN and Global Finance partners to align priorities and deliver measurable outcomes. This role is office-based in London with a minimum of 60% office attendance; travel is limited, primarily within the UK with occasional international exposure. Accountabilities: Full P&L ownership for a designated disease area across the UK & Ireland, spanning in-line and pipeline assets, driving revenue, expense and contribution objectives. Partner disease area leadership to evaluate strategic choices and shape the disease strategic plan, launch readiness and loss-of-exclusivity scenarios. Lead financial modelling and scenario analysis for pricing, reimbursement and access business cases with Market Access and cross functional stakeholders, producing robust recommendations. Represent Finance in senior forums; act as the primary interface between local, EUCAN and Global Finance to align priorities and investment decisions that enable scale and speed. Forecasting, planning & analysis and performance management: Lead strategic plans, annual budgets and monthly forecasts in line with regional and corporate standards and timelines. Apply AI and advanced analytics to strengthen forecasting, scenario modelling, variance analysis and performance insights. Lead business performance reviews with franchise and leadership teams; identify risks and opportunities and drive actions to deliver disease area goals. Ensure disciplined OPEX and investment deployment so resources align to strategic priorities and value delivery. Provide monthly financial reporting and clear commentary to local, EUCAN and International stakeholders, translating analysis into actionable recommendations. Financial governance, controls and capability enablement: Ensure financial integrity through robust month end close, accurate reporting and compliance with Alexion accounting policies and internal controls, in close collaboration with GFS and Controlling. Act as a role model for finance business partnering by building financial acumen across the disease team through coaching, training and day to day decision support. Support the Head of Finance on ad hoc projects and initiatives to strengthen control, capability and performance. Essential Skills/Experience: Significant post qualification experience in finance (FP&A, business partnering or controlling) Experience working in complex, matrix organisations Proven track record in financial planning, forecasting and performance management Strong experience partnering senior stakeholders and influencing decisions Exposure to regional and global finance environments Outstanding analytical skills with ability to connect data to business decisions Strong business partnering and stakeholder influencing skills AI and advanced analytics fluency with ability to translate insights into action Proactive, curious and solutions oriented mindset Ability to challenge constructively and drive continuous improvement Pharma/biotech experience, particularly in disease area or franchise models Experience supporting pricing, reimbursement and access business cases Understanding of UK & Ireland healthcare and reimbursement landscape Experience with financial planning, analytics or visualisation tools Why Alexion: Join a mission driven team focused on improving the lives of people living with rare and devastating conditions through sharp strategy, disciplined execution and bold collaboration. As Alexion, AstraZeneca Rare Disease, we combine the focus and agility of a rare disease leader with the scale and rigor of a global biopharma. We bring finance, market access, medical and commercial together to unlock new approaches that expand access and deliver value. You'll be trusted to speak up, challenge constructively and make smarter, data led decisions. We value kindness alongside ambition and invest in real development opportunities so your work today creates measurable impact for patients tomorrow. Date Posted 23-Jul-2026 Closing Date 20-Aug-2026 Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.
AstraZeneca Otley, Yorkshire
Aug 23, 2026
Full time
Job Title: Senior Scientist Biomarker Lead Introduction to role: Are you ready to turn cutting edge biomarker science into decisive choices in the clinic? As Senior Scientist, Biomarker Lead based in Cambridge, you will design and deliver fit for purpose biomarker strategies and assays that illuminate disease mechanisms, confirm target engagement, and guide patient selection across respiratory and immunologic indications. You will join a hands on discovery group working at the interface of laboratory science and early clinical development. Using human samples and state of the art platforms, you will convert complex datasets into clear, evidence based recommendations, partnering closely with clinicians, translational scientists, and external collaborators. Can you see your work enabling smarter trial designs and faster decisions for patients? From day one, you will own critical biomarker workstreams that influence program direction. Your scientific independence, rigor, and storytelling will help teams move quickly on the right questions and make bold, well supported decisions that accelerate medicines to those who need them. Accountabilities: Assay Strategy and Development: Design, develop, optimise, troubleshoot, transfer, and qualify biomarker assays that demonstrate target engagement, assess pharmacodynamics, enable patient stratification, and support clinical studies. Biomarker Study Leadership: Independently plan, execute, analyze, and document rigorous biomarker studies using human biospecimens to deliver decision enabling data aligned to translational and project objectives. Quality and Compliance Stewardship: Ensure all work adheres to GLS, SOPs, ethical and regulatory requirements; proactively identify and mitigate quality and operational risks. Human Biospecimen Operations: Oversee compliant receipt, processing, tracking, storage, and archiving of human biological samples to safeguard integrity and traceability. Data Interpretation and Decision Support: Critically interpret biomarker results, articulate implications and limitations, and deliver clear, evidence based recommendations to project teams and senior stakeholders. Technology Scouting and Feasibility: Serve as a subject matter expert in biomarker assays, evaluate emerging technologies, and lead feasibility studies that expand translational capability. Cross Functional Partnership: Partner across discovery, translational, clinical, and operations functions to shape biomarker strategy, align priorities, resolve challenges, and deliver high quality outcomes. External Collaboration Enablement: Provide scientific and operational support to academic and clinical collaborators to ensure seamless, compliant execution and data flow. Communication and Knowledge Sharing: Contribute to publications, presentations, reports, and internal forums to disseminate insights and elevate best practices. Progression of Impact: Deliver immediate assay and study outputs, then scale impact by informing program strategy, refining patient selection, and improving clinical decision making. Essential Skills/Experience: PhD with postdoctoral or industry experience in immunology, molecular biology, cell biology, biochemistry, or biomedical sciences; or MS with equivalent progressively responsible laboratory research experience. Extensive experience independently developing, optimising, troubleshooting, qualifying, and applying biomarker assays to deliver decision enabling data. Advanced experience handling and performing experiments with human biological samples, including blood and tissue processing and demonstrated knowledge of sample integrity, biospecimen traceability, ethical standards, applicable regulations, and laboratory compliance requirements. Demonstrated scientific independence and advanced problem solving ability in a laboratory research environment, supported by a proven ability to influence multidisciplinary teams and recommend clear experimental next steps. Advanced written and verbal communication skills, with the ability to synthesise complex scientific and technical information, articulate data implications and limitations, deliver clear recommendations to diverse audiences, and contribute to high quality reports, presentations, and publications. Desirable Skills/Experience: Hands on expertise across multiple biomarker platforms, such as immunoassays, multiparameter flow cytometry, cell based assays, transcriptomics, genomics, proteomics, and NGS based methods, with the ability to select fit for purpose technologies and interpret multidimensional datasets. Deep knowledge of respiratory, immunology, or inflammation biology, with the ability to translate disease mechanisms and scientific evidence into biomarker hypotheses, experimental strategies, and clinically relevant readouts. Comprehensive understanding of drug discovery and development from early research through clinical studies Demonstrated experience applying translational science concepts to drug development-including target engagement, pharmacodynamics, patient stratification, biomarker strategy, assay qualification, and clinical biomarker deployment Why AstraZeneca: Join a science powered organization where evidence guides bold decisions and investment fuels ambition. Here, unexpected teams come together in the same room to unleash original thinking, learn openly from setbacks, and move fast on the work that matters most. You will operate at the cutting edge of discovery and early clinical development, using advanced technologies to answer complex patient needs and shape smarter trials. Your ideas will travel across a diverse, expanding pipeline with real potential to reach patients around the world. We value kindness alongside ambition, and we create the conditions for you to explore new territory, share your work widely, and grow your impact. Date Posted 14-ago.-2026 Closing Date 27-ago.-2026 Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.
AstraZeneca Otley, Yorkshire
Aug 22, 2026
Full time
AstraZeneca in Cambridge seeks a Senior Scientist, Biomarker Lead to design and deliver fit for purpose biomarker strategies and assays that illuminate disease mechanisms, confirm target engagement, and guide patient selection across respiratory and immunologic indications. You will lead critical biomarker workstreams from day one, translating complex data into actionable recommendations for project teams and senior stakeholders while collaborating with clinicians, translational scientists, and
AstraZeneca Otley, Yorkshire
Aug 18, 2026
Full time
Job Title: Translational Science Lead Location: Cambridge Salary: Competitive Introduction to role: Are you ready to convert human biology into decisive clinical evidence that transforms how we treat respiratory disease? Can you see yourself shaping biomarker strategies that define who benefits most from our medicines? Based in Cambridge and reporting to the Senior Group Director, Translational Science, you will lead translational strategy from target selection through early clinical development for respiratory programs. You will connect mechanistic insight to patient impact, delivering clear proof-of-mechanism, target engagement, and precision medicine strategies that guide development decisions and position assets for differentiation and lifecycle opportunities. Working at the intersection of discovery, clinical development and data science, you will design integrated plans, build external collaborations and patient cohorts, and champion the scientific narrative through governance. Your leadership will ensure biomarker assays are fit-for-purpose in the clinic, translational readouts are robust, and the right patients are identified sooner-accelerating the path from mechanism to medicine. Accountabilities: Accountabilities Translational Strategy Leadership: Own and integrate end-to-end translational strategies for respiratory projects and clinical studies, spanning human target validation, target engagement and precision medicine, to drive program decision-making. Human Target Validation: Define human validation plans at target selection, leveraging public and proprietary biobanks to understand biology, responding subpopulations and biomarkers. Mechanistic Insight and Experimental Design: Design and lead innovative experimental approaches and technologies to deepen understanding of disease pathways and drug mechanisms. External Cohorts and Collaborations: Establish and drive collaborations and patient cohorts to enhance disease understanding and identify clinically relevant biomarkers. Data Integration and AI/ML Partnership: Integrate clinical, biomarker and multi-omics data; partner with data science to apply AI/ML for mechanism discovery, biomarker identification and patient phenotyping. Proof-of-Mechanism and Target Engagement: Identify and enable PoM biomarkers and target engagement assays for First-Time-in-Human studies to generate early clinical confidence. Precision Medicine and Patient Stratification: Deliver precision strategies, including early planning for molecular biomarker assay development when clinical features alone are insufficient for patient selection. Clinical Trial Enablement: Develop and execute biomarker sampling strategies; facilitate assay transfer and execution within clinical trials to generate high-quality translational readouts. Governance and Investment Influence: Represent translational strategy in governance and investment forums; enable cross-functional communication for accurate execution. Clinical Document Integration: Embed translational strategy into key clinical documents, including protocols, consent forms, sample lifecycle plans, case report forms, regulatory applications and study reports. Regulatory and Health Authority Interactions: Contribute to responses and author submission sections on mode of action, PK/PD and precision medicine. Scientific Communications: Prepare and review scientific publications to support the scientific and marketing narrative for assets. Essential Skills/Experience PhD with a strong experimental drive and background in Respiratory field Post-doc experience or otherwise relevant scientific research experience 3+ years of experience in a Biomedical or Pharmaceutical role Strong publication record Proven ability to deliver translational readouts and human target validation and their application to drug discovery. Understanding of the Respiratory therapy area including but not limited to COPD, Asthma, NCFBE and IPF, and disease biology, including related molecular pathways and mechanisms. Experience and knowledge of the biological basis for target engagement biomarkers and familiar with PoM and patient selectin biomarkers Broad understanding of relevant technologies and methodologies along with excellent scientific skills and ability to design experiments to address key scientific questions. Excellent skills in hypothesis forming and testing and able to draw conclusions and suggest next steps based on the experimental data. Understanding of pharmacology, translational medicine and clinical sciences as well as clinical development with pre-eminence in at least one of these areas. Demonstrated leadership skills, ability to be a self-starter. Strong team working skills with a proven track record of working collaboratively to ensure scientific excellence and robust delivery to projects. Excellent written, oral, presentation and interpersonal skills. Desirable Skills/Experience prior experience in a Scientific role within the Biomedical or Pharmaceutical Industry Experience from clinical trials Why AstraZeneca Here, you are empowered to follow the science with curiosity and courage, digging deep into the biology of complex disease while harnessing digital, data science and AI to uncover new insights. Unexpected teams often find themselves in the same room, unleashing bold thinking that advances the next generation of therapeutics and improves the odds of clinical success. You will be trusted to explore, supported with the tools and pipeline of a leading R&D organization, and surrounded by collaborators across academia, biotechs and industry-all united by a shared purpose to move faster for patients. We value kindness alongside ambition, balancing big goals with the openness and resilience needed to navigate uncertainty and create meaningful impact. What is next! We look forward to receiving your application not later than 28th August 2026 Date Posted 14-Aug-2026 Closing Date 28-Aug-2026 Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.