UKRI's MRC Genomic Variation and Disease Group invites applications for a three-year, full-time Postdoctoral Research Scientist position based in Hammersmith, London. The role combines molecular biology, genome editing and high-throughput CRISPR screens to study structural variants affecting disease. The successful candidate will work on in vitro and potentially in vivo models, develop scalable methods, publish results and contribute to collaborative science with extensive mentoring and
Sep 15, 2026
Full time
UKRI's MRC Genomic Variation and Disease Group invites applications for a three-year, full-time Postdoctoral Research Scientist position based in Hammersmith, London. The role combines molecular biology, genome editing and high-throughput CRISPR screens to study structural variants affecting disease. The successful candidate will work on in vitro and potentially in vivo models, develop scalable methods, publish results and contribute to collaborative science with extensive mentoring and
MRC Postdoctoral Research Scientist in Gene Regulation and High-Throughput CRISPR screens Genomic Variation and Disease Group (LMS 2880) Salary: £39,375 plus London allowance £3,913 & £1,472 per annum Additional allowances comprises at £1,000 lump sum settlement allowance plus a yearly Training Allowance of £850 in the first year, paid in monthly instalments. The Training Allowance increases to £1,300 in year two, and £1,800 in the third year. 3 years fixed term Full-time Location: Hammersmith London Closing Date: 4 October 2026 Overall purpose: The Genomic Variation and Disease Group works at the intersection of medical genetics, bioinformatics, and molecular biology to explore the mechanisms underlying human diseases. The group uses CRISPR/Cas9 genome editing and synthetic genomics for mouse or human genome rewriting to model disease-causing chromosomal structural variants (SVs) and study their functional consequences. Our challenge is understanding how this type of genomic variation affects molecular and cellular processes to influence organismal phenotypes. We are looking for a talented postdoctoral scientist with a background in molecular biology to join our team. As a key member, you will be part of our collaborative effort to study the molecular mechanisms underlying gene regulation and develop a scalable platform for engineering patient-specific structural variants. Your work will involve in vitro (cellular differentiation) and/or in vivo mouse models, CRISPR/Cas9 genome editing and high-throughput CRISPR screens, and single-cell technologies to investigate the molecular consequences of SVs impacting the noncoding genome. At our newly established lab, we are committed to creating a welcoming and supportive environment where people of all backgrounds can thrive. We value diversity and collaboration and focus on conducting cutting-edge basic and translational science. We provide extensive on-the-job training as needed for the projects. At the LMS, we also offer excellent mentoring and support to help you reach your career goals. As a post holder, you will have the opportunity to work with an extensive network of collaborators, attend scientific conferences, and publish the results of your work in leading journals. Key skills: Background in the field of gene regulation and/or developmental genetics Experience in mouse ES cell culture and common techniques in molecular biology Experience in CRISPR/Cas9 genome editing and high-throughput CRISPR screens Experience in the preparation of targeted NGS libraries is an advantage Experience in in vitro neuronal differentiation is an advantage Experience in immunofluorescence and microscopy imaging is an advantage Experience in single-cell technologies is an advantage Experience in high-throughput chromosome conformation capture (cHi-C) is an advantage Experience in ATAC-seq and Cut&Tag/ChIP-seq is an advantage Main Responsibilities: The general responsibilities will include, but are not limited to, the following activities: Work with group members and collaborators as well as independently on experimental design, data analysis, visualization, and interpretation To prepare work for publication and grant submissions To present at seminars and conferences as necessary To contribute to the smooth running of the Group's/Unit's laboratories and, facilities with other scientists, clinicians, technicians and students within the laboratories To assist in the supervision of undergraduate and postgraduate research students and research assistants as required Education / Qualifications / Training required (will be assessed from application form): Essential: PhD (or equivalent) in Molecular Genetics or a closely related discipline Knowledge and experience (will be assessed from application form and at interview): Essential: Background in the field of gene regulation and/or developmental genetics Experience in mouse ES cell culture and common techniques in molecular biology Experience in CRISPR/Cas9 genome editing and high-throughput CRISPR screens Excellent written communication skills in English and the ability to write clearly for publication Desirable: Experience in the preparation of targeted NGS libraries Experience in in vitro neuronal differentiation Experience in immunofluorescence and microscopy imaging Experience in single-cell technologies Experience in high-throughput chromosome conformation capture (cHi-C) Experience in ATAC-seq and Cut&Tag/ChIP-seq is an advantage Personal skills / Behaviours / Qualities (will be assessed at the interview): Essential: Ability to conduct reproducible research Ability to conduct a detailed review of recent literature Ability to develop and apply new concepts Creative approach to problem-solving A keen interest in learning new skills Excellent verbal communication skills in English and the ability to deal with a wide range of people Ability to motivate others to produce a high standard of work Ability to organise own work with minimal supervision Ability to prioritise own work in response to deadlines Advanced computer skills, including word-processing, spreadsheets and the internet Willingness to work as part of a team and to be open-minded and cooperative Flexible attitude towards work Discipline and regard for confidentiality and security at all times Willingness to undertake any necessary training for the role Additional information: Please note that applications may be reviewed by both LMS and Imperial staff
Sep 15, 2026
Full time
MRC Postdoctoral Research Scientist in Gene Regulation and High-Throughput CRISPR screens Genomic Variation and Disease Group (LMS 2880) Salary: £39,375 plus London allowance £3,913 & £1,472 per annum Additional allowances comprises at £1,000 lump sum settlement allowance plus a yearly Training Allowance of £850 in the first year, paid in monthly instalments. The Training Allowance increases to £1,300 in year two, and £1,800 in the third year. 3 years fixed term Full-time Location: Hammersmith London Closing Date: 4 October 2026 Overall purpose: The Genomic Variation and Disease Group works at the intersection of medical genetics, bioinformatics, and molecular biology to explore the mechanisms underlying human diseases. The group uses CRISPR/Cas9 genome editing and synthetic genomics for mouse or human genome rewriting to model disease-causing chromosomal structural variants (SVs) and study their functional consequences. Our challenge is understanding how this type of genomic variation affects molecular and cellular processes to influence organismal phenotypes. We are looking for a talented postdoctoral scientist with a background in molecular biology to join our team. As a key member, you will be part of our collaborative effort to study the molecular mechanisms underlying gene regulation and develop a scalable platform for engineering patient-specific structural variants. Your work will involve in vitro (cellular differentiation) and/or in vivo mouse models, CRISPR/Cas9 genome editing and high-throughput CRISPR screens, and single-cell technologies to investigate the molecular consequences of SVs impacting the noncoding genome. At our newly established lab, we are committed to creating a welcoming and supportive environment where people of all backgrounds can thrive. We value diversity and collaboration and focus on conducting cutting-edge basic and translational science. We provide extensive on-the-job training as needed for the projects. At the LMS, we also offer excellent mentoring and support to help you reach your career goals. As a post holder, you will have the opportunity to work with an extensive network of collaborators, attend scientific conferences, and publish the results of your work in leading journals. Key skills: Background in the field of gene regulation and/or developmental genetics Experience in mouse ES cell culture and common techniques in molecular biology Experience in CRISPR/Cas9 genome editing and high-throughput CRISPR screens Experience in the preparation of targeted NGS libraries is an advantage Experience in in vitro neuronal differentiation is an advantage Experience in immunofluorescence and microscopy imaging is an advantage Experience in single-cell technologies is an advantage Experience in high-throughput chromosome conformation capture (cHi-C) is an advantage Experience in ATAC-seq and Cut&Tag/ChIP-seq is an advantage Main Responsibilities: The general responsibilities will include, but are not limited to, the following activities: Work with group members and collaborators as well as independently on experimental design, data analysis, visualization, and interpretation To prepare work for publication and grant submissions To present at seminars and conferences as necessary To contribute to the smooth running of the Group's/Unit's laboratories and, facilities with other scientists, clinicians, technicians and students within the laboratories To assist in the supervision of undergraduate and postgraduate research students and research assistants as required Education / Qualifications / Training required (will be assessed from application form): Essential: PhD (or equivalent) in Molecular Genetics or a closely related discipline Knowledge and experience (will be assessed from application form and at interview): Essential: Background in the field of gene regulation and/or developmental genetics Experience in mouse ES cell culture and common techniques in molecular biology Experience in CRISPR/Cas9 genome editing and high-throughput CRISPR screens Excellent written communication skills in English and the ability to write clearly for publication Desirable: Experience in the preparation of targeted NGS libraries Experience in in vitro neuronal differentiation Experience in immunofluorescence and microscopy imaging Experience in single-cell technologies Experience in high-throughput chromosome conformation capture (cHi-C) Experience in ATAC-seq and Cut&Tag/ChIP-seq is an advantage Personal skills / Behaviours / Qualities (will be assessed at the interview): Essential: Ability to conduct reproducible research Ability to conduct a detailed review of recent literature Ability to develop and apply new concepts Creative approach to problem-solving A keen interest in learning new skills Excellent verbal communication skills in English and the ability to deal with a wide range of people Ability to motivate others to produce a high standard of work Ability to organise own work with minimal supervision Ability to prioritise own work in response to deadlines Advanced computer skills, including word-processing, spreadsheets and the internet Willingness to work as part of a team and to be open-minded and cooperative Flexible attitude towards work Discipline and regard for confidentiality and security at all times Willingness to undertake any necessary training for the role Additional information: Please note that applications may be reviewed by both LMS and Imperial staff
Didcot, Oxfordshire, United Kingdom (Hybrid) Job Info Apply Before 08/25/2026, 10:55 PM Job Identification 2704 Posting Date 08/11/2026, 03:16 PM Job Description Salary: £46,743 per annum (Plus Specialist Allowance £2,500 per annum for full member of CIPS). Band: UKRI Band E. Contract Type: Fixed Term (12 Months). Hours: Full Time. Location: Rutherford Appleton Laboratory, Didcot, Oxon - Hybrid Working Available (Minimum 2 days per week in office). Closing date: 25th August 2026. Interviews: W/c 7th September 2026. UKRI Procurement Manager UKRI Commercial is looking to build upon recent growth and success, aiming to develop further to provide excellent commercial support and support its ambitious objectives. This is also a time of significant regulatory change due to the new Procurement Act, making it an exciting period for UKRI Commercial. We welcome candidates who may not have extensive public procurement experience, as we will all be learning the new regulations together. The Science & Technology Facilities Council (STFC) The Science & Technology Facilities Council has a mission to deliver world-leading national and international research and innovation capabilities. Major research and innovation campuses at Harwell, Daresbury and research facilities across the UK support fundamental research in Particle Physics, Technology, space science and many other areas. The Rutherford Appleton Laboratory (RAL), in Harwell Oxfordshire, pioneers work in areas including particle physics, scientific computing, laser development, space research, and technology which addresses some of the important challenges facing society. STFC buys a wide variety of complex and sometimes unique products and services including equipment, technical services and infrastructure to support a range of end-users. About the role To provide expertise and ability to undertake a range of medium value complex procurements including sourcing and contracting. Support end users with, and during, their procurement requirements. Provision of expert advice on all aspects of regulations and controls and representing UKRI's risk appetite in procurement decisions. To keep local end users up-to-date with best practice in procurement. Act as initial contact and escalation route to the Commercial Business Partner. Support the development of local procurement and contract management skill. Your Responsibilities Undertake procurement sourcing and contracting actions using the most appropriate route to market to deliver value and compliance. Provide expert procurement advice to end-users, including guidance on when to direct procurement to the shared service centre. Offer guidance on local procurement issues, making decisions that add value for UKRI. Participate in local commercial assurance, planning, and in-house contract management. About You Confidently use relevant procurement systems to enable effective sourcing and contract management to deliver value for UKRI. Build collaborative relationships with local stakeholders, acting as initial escalation point for key decision making and medium value contract sign-off We seek a dynamic, enthusiastic individual who enjoys applying their skills and experience to procurement projects. The role involves managing diverse stakeholders, and confidence and professional credibility are essential for positive engagement throughout the procurement lifecycle. Personal Specification The below criteria will be scored during Shortlisting (S), Interview (I) or both (S&I). Experience procuring goods or services in a regulated environment (S&I). Proven ability to manage procurement projects from market engagement to contract award (I). Experience in contract management (S). Ability to review and recommend procurement strategies, create tender evaluation models, and produce procurement documentation (S&I). Ability to interpret procurement terms and advise on non-standard terms (I). Excellent interpersonal and communication skills at all levels (S&I). Experience and knowledge of public procurement including Procurement Act 23 and related processes (S&I). MCIPs qualified or willing to work towards (I). We value our employees and offer a competitive pay and rewards package, supporting continuous learning. Benefits include: 30 days' annual leave plus 10.5 public and privilege days (full-time equivalent). Employee discounts on retail and leisure activities. Confidential employee assistance programme Flexible working options. Plus many more benefits and wellbeing initiatives that enable our employees to have a great work life balance! We currently operate a flexible hybrid working arrangement, allowing staff to work three days a week from home. The UKRI Commercial Directorate is also passionate about supporting our team's professional development, and is committed to: A structured mentoring programme for all new starters A variety of ongoing training opportunities delivered internally and externally, to encourage continuing professional development. Support (both financially and with agreed study leave) to complete MCIPS Providing a breadth of experience in procurement and categories of purchasing - from one-off specialist research equipment, construction, professional services, Facilities Management and scientific computing. Please note, if you will require sponsorship to work in the UK, as part of your sponsorship application, you and any dependants travelling with you, will be required to pay costs directly to The Home Office for the application before you start your role with us. UKRI is normally able to reimburse some, or all of these fees after you have become an employee and this can be discussed with the Hiring Manager. For more information, please visit or contact . UKRI seeks to ensure it creates and maintains a system of openness, fairness and inclusion - a collaborative, trusted environment, which is attractive to and accessible to everyone who is interested in developing their career with us. Artificial intelligence can be a useful tool to support your application, however, all examples and statements provided must be truthful, factually accurate and taken directly from your own experience. Where plagiarism has been identified (presenting the ideas and experiences of others, or generated by artificial intelligence, as your own) applications may be rejected and internal candidates may be subject to disciplinary action. As part of the pre-employment checks there is a requirement to undergo Baseline Personnel Security Screening. BPSS is a pre-condition of employment and failure to achieve it may mean that the employment offer is rescinded. UKRI reserves the right to run, or re-run, security clearance as required during the course of employment. About Us UKRI - UK Research and Innovation UKRI is an organisation that brings together the seven disciplinary research councils, Research England and Innovate UK. Together, we build an independent organisation with a strong voice and vision ensuring the UK maintains its world-leading position in research and innovation. Supporting some of the world's most exciting and challenging research projects, we develop and operate some of the most remarkable scientific facilities in the world. We are pushing the frontiers of human knowledge through fundamental research and delivering benefits for UK society and the economy through world-class research, skills and business-led innovation. More information can be found at . Choosing to come to work at UKRI means that you will have access to a whole host of benefits from a defined benefit pension scheme, excellent holiday entitlement, access to employee shopping/travel discounts and salary sacrifice cycle to work scheme. For more details, visit benefits of working for UKRI . How we support EDI in the workforce At UKRI, we believe that everyone has a right to be treated with dignity and respect, and to be provided with equal opportunities to thrive and succeed in an environment that enables them to do so. We also value diversity of thought and experience within inclusive groups, organisations and the wider community. For further information, please visit 'How we support EDI in the workforce'. Disability Confident Employer As users of the disability confident scheme, any candidate who opts into the scheme and best meets the essential criteria, will be shortlisted for interview. We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.
Sep 14, 2026
Full time
Didcot, Oxfordshire, United Kingdom (Hybrid) Job Info Apply Before 08/25/2026, 10:55 PM Job Identification 2704 Posting Date 08/11/2026, 03:16 PM Job Description Salary: £46,743 per annum (Plus Specialist Allowance £2,500 per annum for full member of CIPS). Band: UKRI Band E. Contract Type: Fixed Term (12 Months). Hours: Full Time. Location: Rutherford Appleton Laboratory, Didcot, Oxon - Hybrid Working Available (Minimum 2 days per week in office). Closing date: 25th August 2026. Interviews: W/c 7th September 2026. UKRI Procurement Manager UKRI Commercial is looking to build upon recent growth and success, aiming to develop further to provide excellent commercial support and support its ambitious objectives. This is also a time of significant regulatory change due to the new Procurement Act, making it an exciting period for UKRI Commercial. We welcome candidates who may not have extensive public procurement experience, as we will all be learning the new regulations together. The Science & Technology Facilities Council (STFC) The Science & Technology Facilities Council has a mission to deliver world-leading national and international research and innovation capabilities. Major research and innovation campuses at Harwell, Daresbury and research facilities across the UK support fundamental research in Particle Physics, Technology, space science and many other areas. The Rutherford Appleton Laboratory (RAL), in Harwell Oxfordshire, pioneers work in areas including particle physics, scientific computing, laser development, space research, and technology which addresses some of the important challenges facing society. STFC buys a wide variety of complex and sometimes unique products and services including equipment, technical services and infrastructure to support a range of end-users. About the role To provide expertise and ability to undertake a range of medium value complex procurements including sourcing and contracting. Support end users with, and during, their procurement requirements. Provision of expert advice on all aspects of regulations and controls and representing UKRI's risk appetite in procurement decisions. To keep local end users up-to-date with best practice in procurement. Act as initial contact and escalation route to the Commercial Business Partner. Support the development of local procurement and contract management skill. Your Responsibilities Undertake procurement sourcing and contracting actions using the most appropriate route to market to deliver value and compliance. Provide expert procurement advice to end-users, including guidance on when to direct procurement to the shared service centre. Offer guidance on local procurement issues, making decisions that add value for UKRI. Participate in local commercial assurance, planning, and in-house contract management. About You Confidently use relevant procurement systems to enable effective sourcing and contract management to deliver value for UKRI. Build collaborative relationships with local stakeholders, acting as initial escalation point for key decision making and medium value contract sign-off We seek a dynamic, enthusiastic individual who enjoys applying their skills and experience to procurement projects. The role involves managing diverse stakeholders, and confidence and professional credibility are essential for positive engagement throughout the procurement lifecycle. Personal Specification The below criteria will be scored during Shortlisting (S), Interview (I) or both (S&I). Experience procuring goods or services in a regulated environment (S&I). Proven ability to manage procurement projects from market engagement to contract award (I). Experience in contract management (S). Ability to review and recommend procurement strategies, create tender evaluation models, and produce procurement documentation (S&I). Ability to interpret procurement terms and advise on non-standard terms (I). Excellent interpersonal and communication skills at all levels (S&I). Experience and knowledge of public procurement including Procurement Act 23 and related processes (S&I). MCIPs qualified or willing to work towards (I). We value our employees and offer a competitive pay and rewards package, supporting continuous learning. Benefits include: 30 days' annual leave plus 10.5 public and privilege days (full-time equivalent). Employee discounts on retail and leisure activities. Confidential employee assistance programme Flexible working options. Plus many more benefits and wellbeing initiatives that enable our employees to have a great work life balance! We currently operate a flexible hybrid working arrangement, allowing staff to work three days a week from home. The UKRI Commercial Directorate is also passionate about supporting our team's professional development, and is committed to: A structured mentoring programme for all new starters A variety of ongoing training opportunities delivered internally and externally, to encourage continuing professional development. Support (both financially and with agreed study leave) to complete MCIPS Providing a breadth of experience in procurement and categories of purchasing - from one-off specialist research equipment, construction, professional services, Facilities Management and scientific computing. Please note, if you will require sponsorship to work in the UK, as part of your sponsorship application, you and any dependants travelling with you, will be required to pay costs directly to The Home Office for the application before you start your role with us. UKRI is normally able to reimburse some, or all of these fees after you have become an employee and this can be discussed with the Hiring Manager. For more information, please visit or contact . UKRI seeks to ensure it creates and maintains a system of openness, fairness and inclusion - a collaborative, trusted environment, which is attractive to and accessible to everyone who is interested in developing their career with us. Artificial intelligence can be a useful tool to support your application, however, all examples and statements provided must be truthful, factually accurate and taken directly from your own experience. Where plagiarism has been identified (presenting the ideas and experiences of others, or generated by artificial intelligence, as your own) applications may be rejected and internal candidates may be subject to disciplinary action. As part of the pre-employment checks there is a requirement to undergo Baseline Personnel Security Screening. BPSS is a pre-condition of employment and failure to achieve it may mean that the employment offer is rescinded. UKRI reserves the right to run, or re-run, security clearance as required during the course of employment. About Us UKRI - UK Research and Innovation UKRI is an organisation that brings together the seven disciplinary research councils, Research England and Innovate UK. Together, we build an independent organisation with a strong voice and vision ensuring the UK maintains its world-leading position in research and innovation. Supporting some of the world's most exciting and challenging research projects, we develop and operate some of the most remarkable scientific facilities in the world. We are pushing the frontiers of human knowledge through fundamental research and delivering benefits for UK society and the economy through world-class research, skills and business-led innovation. More information can be found at . Choosing to come to work at UKRI means that you will have access to a whole host of benefits from a defined benefit pension scheme, excellent holiday entitlement, access to employee shopping/travel discounts and salary sacrifice cycle to work scheme. For more details, visit benefits of working for UKRI . How we support EDI in the workforce At UKRI, we believe that everyone has a right to be treated with dignity and respect, and to be provided with equal opportunities to thrive and succeed in an environment that enables them to do so. We also value diversity of thought and experience within inclusive groups, organisations and the wider community. For further information, please visit 'How we support EDI in the workforce'. Disability Confident Employer As users of the disability confident scheme, any candidate who opts into the scheme and best meets the essential criteria, will be shortlisted for interview. We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.
Cambridge, Cambridgeshire, United Kingdom (On-site) Job Info Apply Before 10/11/2026, 10:55 PM Job Identification 2842 Posting Date 09/09/2026, 08:00 AM Job Description £42,694 per annum Overall purpose: To work in the group of Dr Michel Goedert from the Neurobiology Division of the MRC Laboratory of Molecular Biology (LMB), as part of a programme aimed at understanding Molecular Mechanisms of Neurodegeneration. Specifically, to undertake research to develop methods for forming alpha-synuclein filaments with the same structures as those from human brains, This work will be done in close collaboration with the group of Dr Sjors Scheres from the Structural Studies Division of the LMB. The assembly of alpha-synuclein into abnormal amyloid filaments is central to the development of several neurodegenerative diseases, including Parkinson's disease, dementia with Lewy bodies and multiple system atrophy. Since 2020, we have used electron cryo-microscopy (cryo-EM) to show that specific alpha-synuclein determine the structures of alpha-synuclein filaments from human brains. We have shown that specific filament folds define these diseases. Non-proteinaceous densities of unknown composition are also present. To understand mechanisms of disease, one must be able to form filaments that have the same structures as those from human brains in vitro, in cells and in animals. This may require the addition of cofactors of known identity. One successful candidate will use immunoprecipitation and mass spectrometry to identify the chemical identity of cofactors (in collaboration with Professor P. Barran, University of Manchester), The second candidate will develop methods for making alpha-synuclein folds like those from human brains and use cryo-EM to analyse these folds. To undertake research aimed at understanding mechanisms of neurodegeneration. To identify, develop and apply a broad range of techniques to pursue the research objectives. To present scientific work at seminars within the laboratory and at external meetings. To contribute to laboratory-wide discussions on developments within the field. To draft scientific papers and contribute to the overall preparation of research for publication. To contribute to the LMB's mission in the public engagement of science and the translation of research findings into improvements in health care. To assist in the training of PhD students and other members of the LMB. Key responsibilities: Within the overall direction of the programme, the group, the remit of the project and in discussion with the Group Leader, you will make a significant input into determining the direction of the project within a three-year lifespan. To plan your own work and objectives on a 12-month basis and manage your experimental work within the project along with your supervisor. To work with limited supervision to identify, develop, modify and apply the necessary techniques to achieve the goals of the project. To introduce and apply new techniques across a wide range of disciplines and to have the creativity and initiative to develop novel approaches and methods where required. To ensure the research is carried out in accordance with good practice and in compliance with local policies and legal requirements. To contribute to the smooth running of the group, including the effective use of resources, training of others and taking responsibility for use of communal facilities. To enhance your research and generic skills through a tailored development programme. Working relationships: You will report to Dr Michel Goedert and you will interact and collaborate with other Postdoctoral Scientists, Research Support staff and Students, not only in your group, but also across the LMB and with external groups as necessary. Additional information: These positions are three-year training and development positions for Postdoctoral Scientists who have recently completed their doctoral studies, are moving into a new research discipline or have limited experience of key transferable skills. We support Postdoctoral Scientists with a range of formal and on-the-job training, including: MRC training courses. External training and personal development courses. One-to-one training with your Supervisor and other Scientists. You will commit to undertaking the following: Developing and following a personal development plan. Attending training courses. Identifying additional training which will support you to develop your career. Person specification These should include a PhD in a relevant subject or due to complete a PhD within 6 months. Technical skills and expertise: The successful candidates will have experience in the generation of experimental models of amyloid formation and/or cryo-EM/cryo-ET. Experience in standard molecular biology techniques of cloning and cell culture or protein purification are essential. Experience in mass spectrometry can be an advantage. Track record of research: This will include contributions to published papers. Other relevant evidence of: Commitment. Originality. Ability to communicate. Independent working. Working with others. Additional information: Applicants are required to submit a full CV and cover letter. Corporate/local responsibilities & requirements You must carry out your responsibilities with due regard to the UKRI: Code of Conduct Equality, Diversity and Inclusion policy Health and Safety policy Data Protection policy Job descriptions should be reviewed on a regular basis and at the annual appraisal. Any changes should be made and agreed between you and your manager. The above lists are not exhaustive and you are required to undertake such duties as may reasonably be requested within the scope of the post. All employees are required to act professionally, cooperatively and flexibly in line with the requirements of the post, the MRC and UKRI. The role holder will be required to have the appropriate level of security screening/vetting required for the role. UKRI reserves the right to run or re-run security clearance as required in the course of employment. About Us UKRI - UK Research and Innovation UKRI is an organisation that brings together the seven disciplinary research councils, Research England and Innovate UK. Together, we build an independent organisation with a strong voice and vision ensuring the UK maintains its world-leading position in research and innovation. Supporting some of the world's most exciting and challenging research projects, we develop and operate some of the most remarkable scientific facilities in the world. We are pushing the frontiers of human knowledge through fundamental research and delivering benefits for UK society and the economy through world-class research, skills and business led innovation. More information can be found at . Choosing to come to work at UKRI means that you will have access to a whole host of benefits from a defined benefit pension scheme, excellent holiday entitlement, access to employee shopping/travel discounts and salary sacrifice cycle to work scheme. For more details, visit benefits of working for UKRI . How we support EDI in the workforce At UKRI, we believe that everyone has a right to be treated with dignity and respect, and to be provided with equal opportunities to thrive and succeed in an environment that enables them to do so. We also value diversity of thought and experience within inclusive groups, organisations and the wider community. For further information, please visit 'How we support EDI in the workforce'. Disability Confident Employer As users of the disability confident scheme, any candidate who opts into the scheme and best meets the essential criteria, will be shortlisted for interview. We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation. About the Team The MRC Laboratory of Molecular Biology (LMB) is one of the birthplaces of modern molecular biology and has played an important role in the development of many new techniques, most notably X-ray crystallography of proteins, DNA sequencing and monoclonal antibodies. The LMB has a clear goal of understanding biological processes at the molecular level, with the ultimate aim of using this knowledge to tackle specific problems in human health and disease. We aim to tackle difficult, long-term problems, which often require investment over many years. There are four scientific Divisions - Structural Studies, Protein and Nucleic Acid Chemistry, Cell Biology and Neurobiology. However, scientific collaboration between the different Divisions is extensive. Scientists are well supported by excellent scientific facilities and by the LMB Operations Group which maintains the core infrastructure and services of the institute. Our state-of-the-art laboratory provides an unsurpassed environment for both young and established researchers. Scientists are drawn to the LMB from all over the world . click apply for full job details
Sep 13, 2026
Full time
Cambridge, Cambridgeshire, United Kingdom (On-site) Job Info Apply Before 10/11/2026, 10:55 PM Job Identification 2842 Posting Date 09/09/2026, 08:00 AM Job Description £42,694 per annum Overall purpose: To work in the group of Dr Michel Goedert from the Neurobiology Division of the MRC Laboratory of Molecular Biology (LMB), as part of a programme aimed at understanding Molecular Mechanisms of Neurodegeneration. Specifically, to undertake research to develop methods for forming alpha-synuclein filaments with the same structures as those from human brains, This work will be done in close collaboration with the group of Dr Sjors Scheres from the Structural Studies Division of the LMB. The assembly of alpha-synuclein into abnormal amyloid filaments is central to the development of several neurodegenerative diseases, including Parkinson's disease, dementia with Lewy bodies and multiple system atrophy. Since 2020, we have used electron cryo-microscopy (cryo-EM) to show that specific alpha-synuclein determine the structures of alpha-synuclein filaments from human brains. We have shown that specific filament folds define these diseases. Non-proteinaceous densities of unknown composition are also present. To understand mechanisms of disease, one must be able to form filaments that have the same structures as those from human brains in vitro, in cells and in animals. This may require the addition of cofactors of known identity. One successful candidate will use immunoprecipitation and mass spectrometry to identify the chemical identity of cofactors (in collaboration with Professor P. Barran, University of Manchester), The second candidate will develop methods for making alpha-synuclein folds like those from human brains and use cryo-EM to analyse these folds. To undertake research aimed at understanding mechanisms of neurodegeneration. To identify, develop and apply a broad range of techniques to pursue the research objectives. To present scientific work at seminars within the laboratory and at external meetings. To contribute to laboratory-wide discussions on developments within the field. To draft scientific papers and contribute to the overall preparation of research for publication. To contribute to the LMB's mission in the public engagement of science and the translation of research findings into improvements in health care. To assist in the training of PhD students and other members of the LMB. Key responsibilities: Within the overall direction of the programme, the group, the remit of the project and in discussion with the Group Leader, you will make a significant input into determining the direction of the project within a three-year lifespan. To plan your own work and objectives on a 12-month basis and manage your experimental work within the project along with your supervisor. To work with limited supervision to identify, develop, modify and apply the necessary techniques to achieve the goals of the project. To introduce and apply new techniques across a wide range of disciplines and to have the creativity and initiative to develop novel approaches and methods where required. To ensure the research is carried out in accordance with good practice and in compliance with local policies and legal requirements. To contribute to the smooth running of the group, including the effective use of resources, training of others and taking responsibility for use of communal facilities. To enhance your research and generic skills through a tailored development programme. Working relationships: You will report to Dr Michel Goedert and you will interact and collaborate with other Postdoctoral Scientists, Research Support staff and Students, not only in your group, but also across the LMB and with external groups as necessary. Additional information: These positions are three-year training and development positions for Postdoctoral Scientists who have recently completed their doctoral studies, are moving into a new research discipline or have limited experience of key transferable skills. We support Postdoctoral Scientists with a range of formal and on-the-job training, including: MRC training courses. External training and personal development courses. One-to-one training with your Supervisor and other Scientists. You will commit to undertaking the following: Developing and following a personal development plan. Attending training courses. Identifying additional training which will support you to develop your career. Person specification These should include a PhD in a relevant subject or due to complete a PhD within 6 months. Technical skills and expertise: The successful candidates will have experience in the generation of experimental models of amyloid formation and/or cryo-EM/cryo-ET. Experience in standard molecular biology techniques of cloning and cell culture or protein purification are essential. Experience in mass spectrometry can be an advantage. Track record of research: This will include contributions to published papers. Other relevant evidence of: Commitment. Originality. Ability to communicate. Independent working. Working with others. Additional information: Applicants are required to submit a full CV and cover letter. Corporate/local responsibilities & requirements You must carry out your responsibilities with due regard to the UKRI: Code of Conduct Equality, Diversity and Inclusion policy Health and Safety policy Data Protection policy Job descriptions should be reviewed on a regular basis and at the annual appraisal. Any changes should be made and agreed between you and your manager. The above lists are not exhaustive and you are required to undertake such duties as may reasonably be requested within the scope of the post. All employees are required to act professionally, cooperatively and flexibly in line with the requirements of the post, the MRC and UKRI. The role holder will be required to have the appropriate level of security screening/vetting required for the role. UKRI reserves the right to run or re-run security clearance as required in the course of employment. About Us UKRI - UK Research and Innovation UKRI is an organisation that brings together the seven disciplinary research councils, Research England and Innovate UK. Together, we build an independent organisation with a strong voice and vision ensuring the UK maintains its world-leading position in research and innovation. Supporting some of the world's most exciting and challenging research projects, we develop and operate some of the most remarkable scientific facilities in the world. We are pushing the frontiers of human knowledge through fundamental research and delivering benefits for UK society and the economy through world-class research, skills and business led innovation. More information can be found at . Choosing to come to work at UKRI means that you will have access to a whole host of benefits from a defined benefit pension scheme, excellent holiday entitlement, access to employee shopping/travel discounts and salary sacrifice cycle to work scheme. For more details, visit benefits of working for UKRI . How we support EDI in the workforce At UKRI, we believe that everyone has a right to be treated with dignity and respect, and to be provided with equal opportunities to thrive and succeed in an environment that enables them to do so. We also value diversity of thought and experience within inclusive groups, organisations and the wider community. For further information, please visit 'How we support EDI in the workforce'. Disability Confident Employer As users of the disability confident scheme, any candidate who opts into the scheme and best meets the essential criteria, will be shortlisted for interview. We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation. About the Team The MRC Laboratory of Molecular Biology (LMB) is one of the birthplaces of modern molecular biology and has played an important role in the development of many new techniques, most notably X-ray crystallography of proteins, DNA sequencing and monoclonal antibodies. The LMB has a clear goal of understanding biological processes at the molecular level, with the ultimate aim of using this knowledge to tackle specific problems in human health and disease. We aim to tackle difficult, long-term problems, which often require investment over many years. There are four scientific Divisions - Structural Studies, Protein and Nucleic Acid Chemistry, Cell Biology and Neurobiology. However, scientific collaboration between the different Divisions is extensive. Scientists are well supported by excellent scientific facilities and by the LMB Operations Group which maintains the core infrastructure and services of the institute. Our state-of-the-art laboratory provides an unsurpassed environment for both young and established researchers. Scientists are drawn to the LMB from all over the world . click apply for full job details
UKRI - MRC Laboratory of Molecular Biology (LMB) in Cambridge is recruiting postdoctoral scientists for a three-year training and development program. You will join the group led by Dr Michel Goedert to study molecular mechanisms of neurodegeneration using cryo-EM and other state-of-the-art methods. Applicants should have or be nearing a PhD, with strong experimental and collaborative skills. The role involves developing methods, publishing work, and contributing to a dynamic research
Sep 12, 2026
Full time
UKRI - MRC Laboratory of Molecular Biology (LMB) in Cambridge is recruiting postdoctoral scientists for a three-year training and development program. You will join the group led by Dr Michel Goedert to study molecular mechanisms of neurodegeneration using cryo-EM and other state-of-the-art methods. Applicants should have or be nearing a PhD, with strong experimental and collaborative skills. The role involves developing methods, publishing work, and contributing to a dynamic research
National Contact Point (NCP) - Cluster 6 - Food, Bioeconomy, Natural Resources, Agriculture and the Environment Swindon, Wiltshire, United Kingdom (Hybrid) Job Info Apply Before 09/22/2026, 10:55 PM Job Identification 2691 Posting Date 09/01/2026, 03:11 PM Job Description Salary: £46,743 per annum. Band: UKRI Band E. Contract Type: Fixed Term (24 Months). Hours: Full-time/ Part Time (minimum 0.8 FTE) (flexible working available). Location: Swindon, Wiltshire, with regular travel to Brussels, Belgium - Hybrid working available. Closing Date: Tuesday 22nd September 2026. About the Role UK Research and Innovation (UKRI) is recruiting a National Contact Point (NCP) Cluster 6 - Food, Bioeconomy, Natural Resources, Agriculture and the Environment, part of Pillar 2 of Horizon Europe. Based within the Horizon Europe Engagement Team in UKRI International, the role will be responsible for delivering support for UK-based participants in the Cluster 6 Work Programme and the Ocean and Soils Missions. As a recognised expert, you will work as part of the Cluster 6 NCP team providing authoritative advice, guidance and practical support to UK potential applicants, beneficiaries and funded projects across the full project lifecycle. The post supports delivery of Cluster 6 NCP services on behalf of the Department for Business, Innovation, Science and Trade. (DBIST). Responsibilities span awareness-raising, training, stakeholder engagement, policy monitoring and collaboration with the wider European NCP network. The role involves regular engagement with UK partners and European institutions, contributions to communications and briefings, and requires excellent communication and networking skills, confidence presenting to diverse audiences, and the ability to work autonomously in a fast-paced environment. Your responsibilities Provide expert guidance and support to UK organisations across all sectors to help them understand and participate successfully in the Cluster 6 Work Programme and the Missions Work Programme within Horizon Europe and future EU Framework Programmes, in line with European Commission NCP principles. Manage a diverse and largely self-directed portfolio of work, balancing intelligence-gathering, reporting and stakeholder services, including supporting development of successful proposals, to deliver high-impact, added-value support to the UK research and innovation community. Deliver outreach and engagement activities using a range of channels, including events, webinars, briefings, online resources, newsletters and one-to-one support. Work closely with NCP counterparts across Member States and Associated Countries to maintain strong collaborative relationships. Monitor and interpret EU research and innovation policy developments, analysing and sharing timely, high-quality intelligence with UK partners. Work closely with UKRI Councils, DSIT and key partner bodies (such as sector representative organisations and academics) to provide tailored insights and policy support relating to Cluster 6 and the Soil and Oceans Mission. Contribute actively to the Cluster 6 NCP Coordination and Support Action (CSA), delivering agreed activities and outputs. Operate as a core member of the UKRI Horizon Europe Team, collaborating across UKRI and DSIT to support joined-up delivery and initiatives to boost UK participation in Horizon Europe. This is an outline description of the key responsibilities and is not an exhaustive list. The post-holder might be expected to undertake any other duties, commensurate with the Band and level of responsibility of this post, for which the post holder has the necessary experience and/or training. Personal Specification The below criteria will be scored during Shortlisting (S), Interview (I) or both (S&I). A strong understanding of the UK and European research and innovation funding landscape, with experience supporting or enabling engagement in EC Framework Programmes (S&I). Ability to demonstrate initiative, think creatively and analytically to explore new ideas, investigate complex of ambiguous issues and develop clear well-reasoned proposals and practical solutions. (S&I). Experience of developing or delivering projects, demonstrating sound project management and organisational skills (S&I). The ability to multi-task, work flexibly and to plan, prioritise and manage delivery of a diverse portfolio of project and activities with different timescales priorities and delivery mechanisms, working individually and as part of a team (S&I). Strong written and oral communications skills, including the ability to interpret and present information to a wide range of audiences, with clear and concise messaging and provide advice suitable for senior executives and decision-makers (S&I). Ability to work constructively within and across organisations and with people of all levels and internationally to build provide relationships and effective partnerships (S&I). We recognise and value our employees as individuals and aim to provide a favourable pay and rewards package. UKRI are committed to supporting employees' development and promote a culture of continuous learning! A list of benefits below: 30 days' annual leave in addition to 10.5 public and privilege days (full time equivalent). Employee discounts and offers on retail and leisure activities. Employee assistance programme, providing confidential help and advice. Flexible working options. Plus, many more benefits and wellbeing initiatives that enable our employees to have a great work life balance! Please note, if you will require sponsorship to work in the UK, as part of your sponsorship application, you and any dependants travelling with you, will be required to pay costs directly to The Home Office for the application before you start your role with us. UKRI is normally able to reimburse some, or all of these fees after you have become an employee and this can be discussed with the Hiring Manager. For more information, please visit or contact . About Us UKRI - UK Research and Innovation UKRI is an organisation that brings together the seven disciplinary research councils, Research England and Innovate UK. Together, we build an independent organisation with a strong voice and vision ensuring the UK maintains its world-leading position in research and innovation. Supporting some of the world's most exciting and challenging research projects, we develop and operate some of the most remarkable scientific facilities in the world. We are pushing the frontiers of human knowledge through fundamental research and delivering benefits for UK society and the economy through world-class research, skills and business-led innovation. More information can be found at . Choosing to come to work at UKRI means that you will have access to a whole host of benefits from a defined benefit pension scheme, excellent holiday entitlement, access to employee shopping/travel discounts and salary sacrifice cycle to work scheme. For more details, visit benefits of working for UKRI . How we support EDI in the workforce At UKRI, we believe that everyone has a right to be treated with dignity and respect, and to be provided with equal opportunities to thrive and succeed in an environment that enables them to do so. We also value diversity of thought and experience within inclusive groups, organisations and the wider community. For further information, please visit 'How we support EDI in the workforce'. Disability Confident Employer As users of the disability confident scheme, any candidate who opts into the scheme and best meets the essential criteria, will be shortlisted for interview. We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation. UKRI seeks to ensure it creates and maintains a system of openness, fairness and inclusion - a collaborative, trusted environment, which is attractive to and accessible to everyone who is interested in developing their career with us. Artificial intelligence can be a useful tool to support your application, however, all examples and statements provided must be truthful, factually accurate and taken directly from your own experience. Where plagiarism has been identified (presenting the ideas and experiences of others, or generated by artificial intelligence, as your own) applications may be rejected and internal candidates may be subject to disciplinary action. As part of the pre-employment checks there is a requirement to overcome Baseline Personnel Security Screening. BPSS is a pre-condition of employment and failure to achieve it may mean that the employment offer is rescinded. UKRI reserves the right to run, or re-run, security clearance as required during the course of employment.
Sep 07, 2026
Full time
National Contact Point (NCP) - Cluster 6 - Food, Bioeconomy, Natural Resources, Agriculture and the Environment Swindon, Wiltshire, United Kingdom (Hybrid) Job Info Apply Before 09/22/2026, 10:55 PM Job Identification 2691 Posting Date 09/01/2026, 03:11 PM Job Description Salary: £46,743 per annum. Band: UKRI Band E. Contract Type: Fixed Term (24 Months). Hours: Full-time/ Part Time (minimum 0.8 FTE) (flexible working available). Location: Swindon, Wiltshire, with regular travel to Brussels, Belgium - Hybrid working available. Closing Date: Tuesday 22nd September 2026. About the Role UK Research and Innovation (UKRI) is recruiting a National Contact Point (NCP) Cluster 6 - Food, Bioeconomy, Natural Resources, Agriculture and the Environment, part of Pillar 2 of Horizon Europe. Based within the Horizon Europe Engagement Team in UKRI International, the role will be responsible for delivering support for UK-based participants in the Cluster 6 Work Programme and the Ocean and Soils Missions. As a recognised expert, you will work as part of the Cluster 6 NCP team providing authoritative advice, guidance and practical support to UK potential applicants, beneficiaries and funded projects across the full project lifecycle. The post supports delivery of Cluster 6 NCP services on behalf of the Department for Business, Innovation, Science and Trade. (DBIST). Responsibilities span awareness-raising, training, stakeholder engagement, policy monitoring and collaboration with the wider European NCP network. The role involves regular engagement with UK partners and European institutions, contributions to communications and briefings, and requires excellent communication and networking skills, confidence presenting to diverse audiences, and the ability to work autonomously in a fast-paced environment. Your responsibilities Provide expert guidance and support to UK organisations across all sectors to help them understand and participate successfully in the Cluster 6 Work Programme and the Missions Work Programme within Horizon Europe and future EU Framework Programmes, in line with European Commission NCP principles. Manage a diverse and largely self-directed portfolio of work, balancing intelligence-gathering, reporting and stakeholder services, including supporting development of successful proposals, to deliver high-impact, added-value support to the UK research and innovation community. Deliver outreach and engagement activities using a range of channels, including events, webinars, briefings, online resources, newsletters and one-to-one support. Work closely with NCP counterparts across Member States and Associated Countries to maintain strong collaborative relationships. Monitor and interpret EU research and innovation policy developments, analysing and sharing timely, high-quality intelligence with UK partners. Work closely with UKRI Councils, DSIT and key partner bodies (such as sector representative organisations and academics) to provide tailored insights and policy support relating to Cluster 6 and the Soil and Oceans Mission. Contribute actively to the Cluster 6 NCP Coordination and Support Action (CSA), delivering agreed activities and outputs. Operate as a core member of the UKRI Horizon Europe Team, collaborating across UKRI and DSIT to support joined-up delivery and initiatives to boost UK participation in Horizon Europe. This is an outline description of the key responsibilities and is not an exhaustive list. The post-holder might be expected to undertake any other duties, commensurate with the Band and level of responsibility of this post, for which the post holder has the necessary experience and/or training. Personal Specification The below criteria will be scored during Shortlisting (S), Interview (I) or both (S&I). A strong understanding of the UK and European research and innovation funding landscape, with experience supporting or enabling engagement in EC Framework Programmes (S&I). Ability to demonstrate initiative, think creatively and analytically to explore new ideas, investigate complex of ambiguous issues and develop clear well-reasoned proposals and practical solutions. (S&I). Experience of developing or delivering projects, demonstrating sound project management and organisational skills (S&I). The ability to multi-task, work flexibly and to plan, prioritise and manage delivery of a diverse portfolio of project and activities with different timescales priorities and delivery mechanisms, working individually and as part of a team (S&I). Strong written and oral communications skills, including the ability to interpret and present information to a wide range of audiences, with clear and concise messaging and provide advice suitable for senior executives and decision-makers (S&I). Ability to work constructively within and across organisations and with people of all levels and internationally to build provide relationships and effective partnerships (S&I). We recognise and value our employees as individuals and aim to provide a favourable pay and rewards package. UKRI are committed to supporting employees' development and promote a culture of continuous learning! A list of benefits below: 30 days' annual leave in addition to 10.5 public and privilege days (full time equivalent). Employee discounts and offers on retail and leisure activities. Employee assistance programme, providing confidential help and advice. Flexible working options. Plus, many more benefits and wellbeing initiatives that enable our employees to have a great work life balance! Please note, if you will require sponsorship to work in the UK, as part of your sponsorship application, you and any dependants travelling with you, will be required to pay costs directly to The Home Office for the application before you start your role with us. UKRI is normally able to reimburse some, or all of these fees after you have become an employee and this can be discussed with the Hiring Manager. For more information, please visit or contact . About Us UKRI - UK Research and Innovation UKRI is an organisation that brings together the seven disciplinary research councils, Research England and Innovate UK. Together, we build an independent organisation with a strong voice and vision ensuring the UK maintains its world-leading position in research and innovation. Supporting some of the world's most exciting and challenging research projects, we develop and operate some of the most remarkable scientific facilities in the world. We are pushing the frontiers of human knowledge through fundamental research and delivering benefits for UK society and the economy through world-class research, skills and business-led innovation. More information can be found at . Choosing to come to work at UKRI means that you will have access to a whole host of benefits from a defined benefit pension scheme, excellent holiday entitlement, access to employee shopping/travel discounts and salary sacrifice cycle to work scheme. For more details, visit benefits of working for UKRI . How we support EDI in the workforce At UKRI, we believe that everyone has a right to be treated with dignity and respect, and to be provided with equal opportunities to thrive and succeed in an environment that enables them to do so. We also value diversity of thought and experience within inclusive groups, organisations and the wider community. For further information, please visit 'How we support EDI in the workforce'. Disability Confident Employer As users of the disability confident scheme, any candidate who opts into the scheme and best meets the essential criteria, will be shortlisted for interview. We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation. UKRI seeks to ensure it creates and maintains a system of openness, fairness and inclusion - a collaborative, trusted environment, which is attractive to and accessible to everyone who is interested in developing their career with us. Artificial intelligence can be a useful tool to support your application, however, all examples and statements provided must be truthful, factually accurate and taken directly from your own experience. Where plagiarism has been identified (presenting the ideas and experiences of others, or generated by artificial intelligence, as your own) applications may be rejected and internal candidates may be subject to disciplinary action. As part of the pre-employment checks there is a requirement to overcome Baseline Personnel Security Screening. BPSS is a pre-condition of employment and failure to achieve it may mean that the employment offer is rescinded. UKRI reserves the right to run, or re-run, security clearance as required during the course of employment.
£27,406 to £29,343 per annum (pro rata if part-time) Overall purpose: To work within a small team, within an animal holding room, forming part of the larger team known as the Biological Services Group (BSG), whose aim is to support scientific researchers at the MRC Laboratory of Molecular Biology (LMB). Specifically to provide animal husbandry for laboratory mice used in medical research. Main duties/ Key responsibilities: Daily care and maintenance of research mice within individually ventilated caging systems (IVCs). Each room can hold up to 1000 cages Daily welfare observations using good attention to detail in order to check animal numbers and caging information and to report any abnormalities Regular observations of cage cleanliness and changing cage bases to ensure suitable environments for the animals Ensure the animals have access to food, water and environmental enrichment Maintain the animal rooms to a high standard of hygiene, for example; damp-dusting the surfaces, vacuuming and mopping the floors Liaise closely with scientific staff, whose animals you are responsible for Work closely to protocols and Standard Operating Procedures (SOPs) Ensure that Home Office compliance is met in all areas at all times Maintain detailed, accurate records of all activities, using both electronic and written methods Working relationships: Typically you will be a member of a small team (normally 3-5 people), supervised by a senior technician under the overall management of a facility manager. Additional information: You are expected to work overtime for one weekend (2 sessions) every month for which overtime and travel costs will be paid according to UKRI-MRC rates. A session is 3 hours per weekend day. There are opportunities to work additional overtime on weekends and Bank Holidays via a volunteering system. This position involves sustained physical activity, including lifting and moving items such as cages. Candidates should therefore be comfortable with the physically demanding and repetitive aspects of the role. Appointment within the salary range will be commensurate with experience, with higher points reserved for candidates demonstrating significant relevant skills, qualifications, or experience. This job is based on the Babraham Research Campus, there may be occasional travel to our main lab on the Cambridge Biomedical Campus Person Specification Education / qualifications / training required: Essential: An interest in obtaining IAT Level 2 Diploma in Laboratory Animal Science & Technology or equivalent Desirable: GCSEs or equivalent Institute of Animal Technology (IAT) Level 2 Diploma in Laboratory Animal Science & Technology or equivalent Level 2 or 3 Animal Care qualification Relevant scientific degree Previous work experience required: Essential: Experience of caring for animals Experience of working as part of a team Desirable: Experience of working as an animal technician Experience of barriered facilities, including isolation systems e.g. individually ventilated cages (IVCs), and flexible film isolators Working knowledge of Home Office regulations Knowledge of the 3Rs Experience of following written processes and working to strict guidelines Demonstrate an understanding of working to Standard Operating Procedures (SOPs) Experience of using Mouse Colony Management Systems or other similar databases Knowledge and experience: Creativity and initiative Essential: Can demonstrate good attention to detail Independent working Essential: Demonstrate an ability to work independently and follow instructions Acts on own initiative, but also has the ability to know when to seek advice Verbal and written communication skills Essential: Strong written and verbal communication skills Experience of good record keeping, both electronically and written Desirable: Experience of communicating with researchers Personal skills / behaviours / qualities: Essential: A pro-active approach demonstrating commitment to animal welfare with a desire for constant improvement Experience of maintaining high levels of hygiene to ensure a suitable environment Understands the routine nature of animal care Excellent time management and sound interpersonal skills Commitment to undertake standard training programs Ability to demonstrate adaptability and flexibility in order to respond to the changing demands of the animal rooms and overall facility. Ability to meet the physical demands of the role. Able to safely lift and move animal cages weighing up to 5kg Additional Information We welcome applications from all and are open to discuss requests for reasonable adjustments. Corporate Responsibilities You must at all times carry out your responsibilities with due regard to the UKRI: Code of Conduct Equality, Diversity and Inclusion policy Health and Safety policy Data Protection policy Job descriptions should be reviewed on a regular basis and at the annual appraisal. Any changes should be made and agreed between you and your manager. The above lists are not exhaustive and you are required to undertake such duties as may reasonably be requested within the scope of the post. All employees are required to act professionally, co-operatively and flexibly in line with the requirements of the post, the MRC and UKRI. The role holder will be required to have the appropriate level of security screening/vetting required for the role. UKRI reserves the right to run or re-run security clearance as required during the course of employment.
Aug 31, 2026
Full time
£27,406 to £29,343 per annum (pro rata if part-time) Overall purpose: To work within a small team, within an animal holding room, forming part of the larger team known as the Biological Services Group (BSG), whose aim is to support scientific researchers at the MRC Laboratory of Molecular Biology (LMB). Specifically to provide animal husbandry for laboratory mice used in medical research. Main duties/ Key responsibilities: Daily care and maintenance of research mice within individually ventilated caging systems (IVCs). Each room can hold up to 1000 cages Daily welfare observations using good attention to detail in order to check animal numbers and caging information and to report any abnormalities Regular observations of cage cleanliness and changing cage bases to ensure suitable environments for the animals Ensure the animals have access to food, water and environmental enrichment Maintain the animal rooms to a high standard of hygiene, for example; damp-dusting the surfaces, vacuuming and mopping the floors Liaise closely with scientific staff, whose animals you are responsible for Work closely to protocols and Standard Operating Procedures (SOPs) Ensure that Home Office compliance is met in all areas at all times Maintain detailed, accurate records of all activities, using both electronic and written methods Working relationships: Typically you will be a member of a small team (normally 3-5 people), supervised by a senior technician under the overall management of a facility manager. Additional information: You are expected to work overtime for one weekend (2 sessions) every month for which overtime and travel costs will be paid according to UKRI-MRC rates. A session is 3 hours per weekend day. There are opportunities to work additional overtime on weekends and Bank Holidays via a volunteering system. This position involves sustained physical activity, including lifting and moving items such as cages. Candidates should therefore be comfortable with the physically demanding and repetitive aspects of the role. Appointment within the salary range will be commensurate with experience, with higher points reserved for candidates demonstrating significant relevant skills, qualifications, or experience. This job is based on the Babraham Research Campus, there may be occasional travel to our main lab on the Cambridge Biomedical Campus Person Specification Education / qualifications / training required: Essential: An interest in obtaining IAT Level 2 Diploma in Laboratory Animal Science & Technology or equivalent Desirable: GCSEs or equivalent Institute of Animal Technology (IAT) Level 2 Diploma in Laboratory Animal Science & Technology or equivalent Level 2 or 3 Animal Care qualification Relevant scientific degree Previous work experience required: Essential: Experience of caring for animals Experience of working as part of a team Desirable: Experience of working as an animal technician Experience of barriered facilities, including isolation systems e.g. individually ventilated cages (IVCs), and flexible film isolators Working knowledge of Home Office regulations Knowledge of the 3Rs Experience of following written processes and working to strict guidelines Demonstrate an understanding of working to Standard Operating Procedures (SOPs) Experience of using Mouse Colony Management Systems or other similar databases Knowledge and experience: Creativity and initiative Essential: Can demonstrate good attention to detail Independent working Essential: Demonstrate an ability to work independently and follow instructions Acts on own initiative, but also has the ability to know when to seek advice Verbal and written communication skills Essential: Strong written and verbal communication skills Experience of good record keeping, both electronically and written Desirable: Experience of communicating with researchers Personal skills / behaviours / qualities: Essential: A pro-active approach demonstrating commitment to animal welfare with a desire for constant improvement Experience of maintaining high levels of hygiene to ensure a suitable environment Understands the routine nature of animal care Excellent time management and sound interpersonal skills Commitment to undertake standard training programs Ability to demonstrate adaptability and flexibility in order to respond to the changing demands of the animal rooms and overall facility. Ability to meet the physical demands of the role. Able to safely lift and move animal cages weighing up to 5kg Additional Information We welcome applications from all and are open to discuss requests for reasonable adjustments. Corporate Responsibilities You must at all times carry out your responsibilities with due regard to the UKRI: Code of Conduct Equality, Diversity and Inclusion policy Health and Safety policy Data Protection policy Job descriptions should be reviewed on a regular basis and at the annual appraisal. Any changes should be made and agreed between you and your manager. The above lists are not exhaustive and you are required to undertake such duties as may reasonably be requested within the scope of the post. All employees are required to act professionally, co-operatively and flexibly in line with the requirements of the post, the MRC and UKRI. The role holder will be required to have the appropriate level of security screening/vetting required for the role. UKRI reserves the right to run or re-run security clearance as required during the course of employment.
UKRI's MRC Laboratory of Molecular Biology (LMB) invites applications for a Technician in the Biological Services Group at the Babraham Research Campus. You will provide daily husbandry for laboratory mice in individually ventilated cages, maintaining high welfare and accurate records in line with SOPs. The role requires teamwork, attention to detail, and a proactive approach to animal care, with opportunities for overtime work on weekends paid according to UKRI-MRC rates.
Aug 31, 2026
Full time
UKRI's MRC Laboratory of Molecular Biology (LMB) invites applications for a Technician in the Biological Services Group at the Babraham Research Campus. You will provide daily husbandry for laboratory mice in individually ventilated cages, maintaining high welfare and accurate records in line with SOPs. The role requires teamwork, attention to detail, and a proactive approach to animal care, with opportunities for overtime work on weekends paid according to UKRI-MRC rates.
MRC Laboratory of Molecular Biology (LMB) in Cambridge, UK, invites applications for a three-year Postdoctoral Scientist position within a programme linking microtubule motors to cargo. The role involves developing techniques, collaborating across labs, and contributing to publications. The successful applicant will have a PhD, experience in mammalian cell culture and advanced light microscopy, with CRISPR tagging a plus. Salary £42,694 per annum.
Aug 31, 2026
Full time
MRC Laboratory of Molecular Biology (LMB) in Cambridge, UK, invites applications for a three-year Postdoctoral Scientist position within a programme linking microtubule motors to cargo. The role involves developing techniques, collaborating across labs, and contributing to publications. The successful applicant will have a PhD, experience in mammalian cell culture and advanced light microscopy, with CRISPR tagging a plus. Salary £42,694 per annum.
£42,694 per annum Overall purpose: To work within the group of Andrew Carter at the MRC Laboratory of Molecular Biology (LMB), within a programme aimed at identifying the links between microtubule motors and their cargos. The project will be in collaboration with the lab of Emmanuel Derivery and benefit from combining their expertise in multispectral imaging, together with the Carter lab's expertise in working with iNeurons and motor transport. The goal is to identify the connections that link motors to specific cargos such as membrane organelles, viruses or RNAs. Main duties: To undertake research aimed at identifying the links between microtubule motors and their cargos. To identify, develop and apply a broad range of techniques to pursue the research objectives. To present scientific work at seminars within the laboratory and at external meetings. To contribute to laboratory-wide discussions on developments within the field. To draft scientific papers, and contribute to the overall preparation of research for publication. To contribute to the LMB's mission in the public engagement of science, and the translation of research findings into improvements in health care. To assist in the training of PhD students and other members of the LMB. Key responsibilities: Within the overall direction of the programme, the group, the remit of the project and in discussion with the Group Leader, you will make a significant input into determining the direction of the project within a three year lifespan. To plan your own work and objectives on a 12-month basis and manage your experimental work within the project along with your Supervisor. To work with limited supervision to identify, develop, modify and apply the necessary techniques to achieve the goals of the project. To introduce and apply new techniques across a wide range of disciplines and to have the creativity and initiative to develop novel approaches and methods where required. To ensure the research is carried out in accordance with good practice and in compliance with local policies and legal requirements. To contribute to the smooth running of the group, including the effective use of resources, training of others and taking responsibility for use of communal facilities. To enhance your research and generic skills through a tailored development programme. Working relationships: You will report to Dr Andrew Carter and will interact and collaborate with other Postdoctoral Scientists, Research Support staff and students, not only in your group, but also across the LMB and with external groups as necessary. Additional information: This is a three-year training and development position for a Postdoctoral Scientist who has recently completed their doctoral studies, is moving into a new research discipline or has limited experience of key transferable skills. We support Postdoctoral Scientists with a range of formal and on-the-job training, including: MRC training courses. External training and personal development courses. One-to-one training with your Supervisor and other Scientists. You will commit to undertaking the following: Developing and following a personal development plan. Attending training courses. Identifying additional training which will support you to develop your career. Person Specification Academic qualifications: These should include a PhD in a relevant subject or due to complete PhD within 6 months. Technical skills and expertise: Experience of and ability to perform techniques relevant to the project. Essential would be experience of mammalian cell culture and advanced light microscopy. Experience with CRISPR tagging and/or generating protein binders would be an advantage. Track record of research: This will include achievements, and contributions to published papers. Other relevant evidence of: Commitment. Originality. Ability to communicate. Working with others. Corporate Responsibilities You must at all times carry out your responsibilities with due regard to the UKRI: Code of Conduct Equality, Diversity and Inclusion policy Health and Safety policy Data Protection policy Job descriptions should be reviewed on a regular basis and at the annual appraisal. Any changes should be made and agreed between you and your manager. The above lists are not exhaustive and you are required to undertake such duties as may reasonably be requested within the scope of the post. All employees are required to act professionally, co-operatively and flexibly in line with the requirements of the post, the MRC and UKRI. The role holder will be required to have the appropriate level of security screening/vetting required for the role. UKRI reserves the right to run or re-run security clearance as required during the course of employment.
Aug 31, 2026
Full time
£42,694 per annum Overall purpose: To work within the group of Andrew Carter at the MRC Laboratory of Molecular Biology (LMB), within a programme aimed at identifying the links between microtubule motors and their cargos. The project will be in collaboration with the lab of Emmanuel Derivery and benefit from combining their expertise in multispectral imaging, together with the Carter lab's expertise in working with iNeurons and motor transport. The goal is to identify the connections that link motors to specific cargos such as membrane organelles, viruses or RNAs. Main duties: To undertake research aimed at identifying the links between microtubule motors and their cargos. To identify, develop and apply a broad range of techniques to pursue the research objectives. To present scientific work at seminars within the laboratory and at external meetings. To contribute to laboratory-wide discussions on developments within the field. To draft scientific papers, and contribute to the overall preparation of research for publication. To contribute to the LMB's mission in the public engagement of science, and the translation of research findings into improvements in health care. To assist in the training of PhD students and other members of the LMB. Key responsibilities: Within the overall direction of the programme, the group, the remit of the project and in discussion with the Group Leader, you will make a significant input into determining the direction of the project within a three year lifespan. To plan your own work and objectives on a 12-month basis and manage your experimental work within the project along with your Supervisor. To work with limited supervision to identify, develop, modify and apply the necessary techniques to achieve the goals of the project. To introduce and apply new techniques across a wide range of disciplines and to have the creativity and initiative to develop novel approaches and methods where required. To ensure the research is carried out in accordance with good practice and in compliance with local policies and legal requirements. To contribute to the smooth running of the group, including the effective use of resources, training of others and taking responsibility for use of communal facilities. To enhance your research and generic skills through a tailored development programme. Working relationships: You will report to Dr Andrew Carter and will interact and collaborate with other Postdoctoral Scientists, Research Support staff and students, not only in your group, but also across the LMB and with external groups as necessary. Additional information: This is a three-year training and development position for a Postdoctoral Scientist who has recently completed their doctoral studies, is moving into a new research discipline or has limited experience of key transferable skills. We support Postdoctoral Scientists with a range of formal and on-the-job training, including: MRC training courses. External training and personal development courses. One-to-one training with your Supervisor and other Scientists. You will commit to undertaking the following: Developing and following a personal development plan. Attending training courses. Identifying additional training which will support you to develop your career. Person Specification Academic qualifications: These should include a PhD in a relevant subject or due to complete PhD within 6 months. Technical skills and expertise: Experience of and ability to perform techniques relevant to the project. Essential would be experience of mammalian cell culture and advanced light microscopy. Experience with CRISPR tagging and/or generating protein binders would be an advantage. Track record of research: This will include achievements, and contributions to published papers. Other relevant evidence of: Commitment. Originality. Ability to communicate. Working with others. Corporate Responsibilities You must at all times carry out your responsibilities with due regard to the UKRI: Code of Conduct Equality, Diversity and Inclusion policy Health and Safety policy Data Protection policy Job descriptions should be reviewed on a regular basis and at the annual appraisal. Any changes should be made and agreed between you and your manager. The above lists are not exhaustive and you are required to undertake such duties as may reasonably be requested within the scope of the post. All employees are required to act professionally, co-operatively and flexibly in line with the requirements of the post, the MRC and UKRI. The role holder will be required to have the appropriate level of security screening/vetting required for the role. UKRI reserves the right to run or re-run security clearance as required during the course of employment.
UKRI Salary: £46,743. Band: UKRI Band E. Contract: 24 months FTC. Hours: Min 0.7FTE/Full time. Location: Polaris House, Swindon - Hybrid Working Available. Closing Date: Tuesday 16th June 2026 click apply for full job details
May 30, 2026
Seasonal
UKRI Salary: £46,743. Band: UKRI Band E. Contract: 24 months FTC. Hours: Min 0.7FTE/Full time. Location: Polaris House, Swindon - Hybrid Working Available. Closing Date: Tuesday 16th June 2026 click apply for full job details
UK Research & Innovation Salary: £58,589 - £74,866 per annum. (Dependent on experience) Band: UKRI Band F. Contract Type: Open ended. Hours: Full-time. (flexible working available) Location: Polaris House, Swindon, Wiltshire or Rutherford Appleton Laboratory, Didcot, Oxon - Hybrid working available click apply for full job details
May 22, 2026
Full time
UK Research & Innovation Salary: £58,589 - £74,866 per annum. (Dependent on experience) Band: UKRI Band F. Contract Type: Open ended. Hours: Full-time. (flexible working available) Location: Polaris House, Swindon, Wiltshire or Rutherford Appleton Laboratory, Didcot, Oxon - Hybrid working available click apply for full job details
UK Research & Innovation Salary: £58,589 - £74,866 per annum. (Dependent on experience) Band: UKRI Band F. Contract Type: Open ended. Hours: Full-time. (flexible working available) Location: Polaris House, Swindon, Wiltshire or Rutherford Appleton Laboratory, Didcot, Oxon - Hybrid working available click apply for full job details
May 19, 2026
Full time
UK Research & Innovation Salary: £58,589 - £74,866 per annum. (Dependent on experience) Band: UKRI Band F. Contract Type: Open ended. Hours: Full-time. (flexible working available) Location: Polaris House, Swindon, Wiltshire or Rutherford Appleton Laboratory, Didcot, Oxon - Hybrid working available click apply for full job details
A leading research organization in Harwell UK is seeking a motivated placement student to join their Technology Department. The student will engage in valuable projects, particularly in X-ray camera development. Responsibilities include conducting experiments, data analysis, and communication of results. Ideal candidates should have a solid academic background in Physics or Electronics and practical skills in electronics or data processing. Benefits include 30 days of holiday, flexible working, and excellent learning opportunities.
Mar 06, 2026
Full time
A leading research organization in Harwell UK is seeking a motivated placement student to join their Technology Department. The student will engage in valuable projects, particularly in X-ray camera development. Responsibilities include conducting experiments, data analysis, and communication of results. Ideal candidates should have a solid academic background in Physics or Electronics and practical skills in electronics or data processing. Benefits include 30 days of holiday, flexible working, and excellent learning opportunities.
