GlaxoSmithKline

Overview Senior Director, Translational Genetics. This role leads a team of translational genetics scientists within the GSK R&D Translational Sciences organization. The successful candidate provides strategic leadership, deep analytical expertise, and collaborates across functions to identify, develop, and deliver a portfolio of translational, data-driven work to accelerate delivery of the GSK portfolio. The team supports target assessments across priority therapeutic areas and addresses translational questions by integrating genetics with genomics (including proteomics) and clinical phenotypic data. The candidate should have strong expertise in association genetics and experience applying statistical genetics approaches to translational questions. The role informs target discovery and validation, biomarker discovery and characterization, indication and patient subgroup selection, and advances understanding of disease pathobiology. The team works in a multidisciplinary, collaborative environment, interacting with GSK scientists and leaders to advance drug discovery and clinical development. The role also involves establishing external collaborations aligned with strategic priorities and opportunities for leadership development and excellence through impactful work. Key Responsibilities Provide strategic leadership to set the direction of the team, ensuring alignment with evolving organizational priorities and delivering against timelines. Utilize expertise in genetic analysis and the integration of genetics with genomic (including proteomics) and clinical phenotypic data to address translational questions and generate disease-relevant, at-scale insights. Contribute hands-on analytical work to accelerate delivery of work packages impacting the GSK drug development pipeline. Lead cross-functional GSK project teams when appropriate, with emphasis on respiratory, hepatology, neurodegeneration, immunology, and/or renal disease. Identify, set up, and oversee externally aligned scientific collaborations. Communicate analysis findings clearly to project teams and senior leaders. Deliver personal and team outputs against objectives with strong statistical, analytical, and critical thinking within a translational context. Stay current with advances in translational genetics and the integration of genetics with genomics to address translational questions. Lead a team of direct reports and foster a culture of innovation, collaboration, and continuous professional learning. Qualifications PhD or equivalent advanced degree in a relevant scientific discipline (e.g., statistical genetics, genetic epidemiology, biomedical statistics, computational sciences, bioinformatics, or machine learning) with a track record of impactful publications and/or presentations. Experience in genetics analyses that integrate genetics, genomics, and/or clinical phenotypic data to inform drug discovery and development. Proven ability to work effectively in multidisciplinary teams and communicate complex concepts to diverse audiences. Advanced ability to identify and deliver innovative analytical solutions to address specific translational questions. Experience in developing and implementing new methodologies to integrate genetics and genomics in drug discovery and development. Experience in establishing and managing external collaborations to deliver impact for all parties. Ability to prioritize resources dynamically and align work with organizational priorities to maximize impact. Experience in leading and managing a high-performance team. Strong proficiency in at least one of R or Python, with a track record of writing reproducible, scalable code aligned with FAIR principles. Demonstrable understanding of stages of drug discovery and development. Additional Information Locations that may apply include Cambridge, MA; Waltham, MA; Rockville, MD; or San Francisco, CA. Salary ranges and bonus eligibility reflect location and other factors. Benefits include health care, retirement benefits, paid holidays, vacation, and paid caregiver/parental and medical leave. GSK is an Equal Opportunity Employer. Flexible/hybrid work options may be available. If you require adjustments to the recruitment process, contact . For general information on compensation and benefits, details are provided in the recruitment materials. See the company's Equal Opportunity and non-discrimination statements in the job posting.

About the Role The Onyx Research Data Tech organization represents a major investment by GSK R&D and Digital & Tech, designed to deliver a step-change in our ability to leverage data, knowledge, and prediction to find new medicines. It is a full stack shop that brings together product and portfolio leadership, data engineering, infrastructure and DevOps, data / metadata / knowledge platforms, and AI/ML and analysis platforms. Our focus is on creating a next generation data experience for GSK's scientists, engineers, and decision makers, increasing productivity and reducing time spent on "data mechanics." We are seeking an experienced Director, Molecule Design Products who will be accountable for designing and delivering the roadmap for molecule design products to support GSK Research and Development. The Director will be responsible for defining and executing the comprehensive product strategy for our entire portfolio of AI powered solutions aimed at accelerating drug discovery. You will build, mentor, and lead a high performing team of Product Managers, driving the strategic adoption of Generative AI, LLMs, and autonomous agents to revolutionise how we design molecules. Responsibilities Portfolio Strategy & Vision: Define and champion the overarching product strategy, vision, and roadmap for the entire Molecule Design product portfolio, ensuring alignment with Onyx's and GSK R&D's strategic objectives and long term scientific breakthroughs; oversee timely delivery of product features and solutions across the portfolio to maximise scientific impact and business outcomes. Team Leadership & Development: Build, mentor, and lead a high performing team of Product Managers and Senior Product Managers, fostering a culture of innovation, user centricity, accountability, and continuous professional growth. AI/GenAI Portfolio Leadership & Modernisation: Drive the strategic direction for leveraging Generative AI, LLMs, and autonomous AI Agents across the entire Molecule Design portfolio, identifying breakthrough opportunities to automate and enhance complex scientific research tasks. Define a comprehensive product modernisation strategy and oversee the transformation of legacy tools into AI ready solutions. Human AI Interaction & User Experience: Champion the strategic approach to human AI collaboration and interaction design for the portfolio, ensuring agentic systems provide intuitive, powerful, and ethical experiences for scientists. Executive & Cross Functional Influence: Foster deep strategic partnerships with executive level product, engineering, and scientific leadership; influence key stakeholders across R&D, Tech, and partner functions to align on product vision, secure resources, and drive adoption. Strategic Portfolio Growth & Capability Sourcing: Identify, evaluate, and champion significant strategic market opportunities and external partnerships; lead critical "buy vs. build" decisions for core capabilities across the Molecule Design product portfolio. Performance & Governance: Define and oversee the strategic framework for portfolio level performance metrics, governance guidelines, and continuous improvement mechanisms for all AI powered molecule design products; embed responsible AI practices and data governance throughout the product lifecycle. Technical Architecture Guidance: Provide strategic guidance on the technical architecture and infrastructure required to build and scale the Molecule Design product portfolio, including cloud native solutions, data pipelines, and multi agent system architectures. Qualifications & Skills We are looking for professionals with these required skills: Bachelors degree in a technical or scientific field, with a focus on computational science, biomedical sciences, AI, data science, software engineering, or a related discipline. Significant experience in product management, with a substantial amount in a leadership role and a proven track record of driving significant product modernisation initiatives. Proven track record of defining and executing a product strategy for a portfolio of 0 to 1 products or product lines, specifically in the life science domain, including the strategic transformation of existing products. Demonstrated expertise in Generative AI, LLMs, and autonomous AI agents, with a deep understanding of their application in complex technical or scientific problem spaces. Deep technical fluency with cloud native architectures (e.g., AWS, GCP, Azure), API design, and the infrastructure required to serve and scale advanced AI/ML applications. Preferred Qualifications & Skills Master's or PhD in a technical or scientific field, with a focus on computational science, biomedical sciences, AI, data science, software engineering, or a related discipline. Exceptional leadership and communication skills, with the ability to articulate complex technical and strategic concepts to diverse audiences. Extensive experience designing, optimising, and implementing strategic approaches to Model Context Protocols (MCP) for LLM powered agents across multiple products. Hands on software engineering or data science experience, particularly in GenAI, prior to transitioning into product leadership. Proven ability to build and scale products that manage or interpret complex, unstructured data, particularly biomedical or scientific data. Deep knowledge of bioinformatics, computational biology, or cheminformatics, coupled with a visionary perspective on how agentic AI can revolutionise the drug discovery process. Prior experience in the life science industry, biopharma R&D, or a highly regulated scientific domain, including technology adoption and change management for established platforms. Experience in strategic partnership development or commercialisation of deep technology products. Equal Opportunity Employer GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, colour, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law.

GlaxoSmithKline is seeking an Interventional Study Scientist Director to lead the scientific design and execution of clinical studies. This role focuses on oncology and involves collaboration with cross-functional teams to ensure high-quality studies that align with strategic objectives. Candidates should possess an advanced scientific degree and substantial clinical research experience. GSK values innovation, inclusion, and offers flexible working arrangements as part of its commitment to a healthy work-life balance.

Interventional Study Scientist Director Locations: GSK HQ, New Oxford Street & USA - Upper Providence Reports to: Head of Interventional & Supported Studies Join GSK's Medical Affairs team and be part of a global organization that drives innovation, scientific excellence, and patient-centered solutions. As a member of the Medical Affairs organization, you'll collaborate with cross-functional teams to shape clinical practice, engage with healthcare professionals, and deliver on our promise to help people do more, feel better, and live longer. This role offers an exciting opportunity to lead the scientific design and execution of interventional clinical studies within the Medical Affairs organization for oncology or hematology assets. You will shape data generation strategies, ensure studies are conducted with the highest standards of quality and ethics, and collaborate with cross-functional teams to deliver impactful results. In this role, you will: Design and oversee interventional clinical studies, ensuring alignment with strategic objectives and evidence plans. Provide scientific oversight for study protocols, analysis plans, and interpretation of study data. Ensure patient safety and scientific integrity throughout study conduct, including medical governance and monitoring. Collaborate with cross-functional teams to ensure seamless execution and delivery of clinical programs. Prepare and present study results for scientific meetings, publications, and regulatory submissions. Engage with internal and external stakeholders, including investigators and thought leaders, to enhance study design and execution. Basic Qualifications & Skills Advanced degree in a relevant scientific discipline (MD, PhD, PharmD, or equivalent). Specialized experience in oncology, pulmonology, hepatology or a related therapeutic area. Considerable experience in clinical research, including interventional studies. Proven experience designing and executing clinical trials with demonstrated impact. Strong understanding of regulatory requirements and industry best practices for clinical research. Experience leading cross-functional teams in a matrixed environment. Excellent communication and organizational skills. Preferred Qualifications & Skills Experience leading multi-country or global interventional studies. Experience collaborating with regulatory authorities. Familiarity with innovative approaches in clinical trial design and execution. Exposure to working with key opinion leaders, investigators, and external partners. Experience developing scientific content for publications and regulatory submissions. Understanding of digital tools and methodologies for evidence generation. What we offer You will join a team focused on scientific rigour and patient impact. You will gain leadership exposure across functions and grow your clinical development expertise. We value inclusion, work-life balance, and career development. We offer a flexible working culture. GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law.

Site Name: UK - Hertfordshire - Stevenage, GSK HQ, USA - Massachusetts - Waltham, USA - North Carolina - Durham, USA - Pennsylvania - Upper Providence Posted Date: May 5 2026 Director, Translational Science Lead - Respiratory R&D Translational Sciences, part of the newly formed Translational & Developmental Sciences (TDS), is accountable for end-to-end disease area translational science to inform therapy area and program level biomarker strategies (from preclinical to launch) to increase the probability of success from preclinical to clinical transitions and enable earlier and higher confidence asset related decisions. This includes generation of foundational data as well as disease biomarker development and validation that allow timely deployment of tools/biomarkers to support Proof of Mechanism (PoM), signs of clinical efficacy, Proof of Concept (PoC), and pairing Mechanisms of Action (MoAs) with patient subtypes to predict responder populations. We are looking for a dynamic individual to excel in the following responsibilities. Key Responsibilities: Disease Biomarker Strategy Development and Delivery: Partner with the Clinical Teams, R&D Technologies and the RIIRU Early Pipeline Unit with focus on Respiratory portfolio to identify, establish biomarkers for decision making throughout clinical development phases and aligned with the overall research and development goals. This will include the identification, prioritisation and validation of disease relevant biomarkers, mechanistic/surrogate biomarkers, patient stratification, and differentiated response prediction, their deployment into clinical studies and interpretation of data/results. Translational Leadership: Provide strategic leadership contributing to deep understanding of disease areas enabling the development and execution of translational research disease strategies to support the discovery and development of novel differentiated therapeutics including evaluation and diligence of business development opportunities. Translational innovation: Evaluate novel techniques and technologies (i.e. spatial transcriptomics) to inform translational initiatives, biomarker development and validation working in collaboration with platform teams and within a multi-functional matrix environment. Identify and guide validation of human assays (cells, tissues and organs) to enhance human translation and predictive value through the application of resources such as the Human Cell Atlas, disease tissue multi-omics data and genetic resources (external or proprietary). Cross-functional Collaboration: Collaborate closely with cross-functional teams including the Translational Disease Teams, biology groups, biomarker platforms, Medicine Development Teams, HBSM, data-sciences, regulatory affairs, business development and commercial to ensure seamless integration of translational research and biomarker strategies across the drug development lifecycle. External Partnerships: Establish and maintain strategic collaborations with academic institutions, contract research organizations (CROs), and other external partners to access cutting-edge technologies, tools, reagents, biosamples, biomarker expertise, and research capabilities. o Foster a network of external experts and key opinion leaders to stay at the forefront of translational science and biomarker advancements across the industry. Contribute to evaluation and diligence of business development opportunities. Matrix Leadership: Provide mentorship, guidance, and professional development opportunities to ensure a high-performing and motivated team. Manage disease and project level resources, budgets, and timelines to ensure the successful execution of projects and achievement of milestones and R&D Translational Science objectives. Represent Translational Science at portfolio governance reviews providing critical input to pipeline and investment decision making. Why you? Basic Qualifications: We are looking for professionals with these required skills to achieve our goals: Ph.D. in a Scientific / Life Science discipline (e.g., Cell/Molecular Biology, Genetics, Pharmacology, Physical Chemistry or related field). Extensive experience in translational science and biomarker development ideally within the pharmaceutical or biotechnology industry. Recognized translational/biomarker expert in scientific community through publications and contributions to the field. Experience of translation and biomarkers implementation in Respiratory indications. Experience of working in a clinical trial setting, working as part of a clinical study and experience of authoring and oversight of clinical and regulatory documents. Experience / working knowledge of regulatory requirements, industry standards, best practices and compliance considerations in Translational Research and biomarker development and validation. Experience in technologies and methods used in translational research. Proven track record of program decision making through implementing biomarker strategies and delivering translational science insights in support of drug progression through clinical transition milestones. Experience leading/managing external collaborations and evaluation of business development opportunities. Experienced matrix leader with the ability to create psychological safety, inspire and motivate a team towards achieving common goals. Preferred Qualifications: If you have the following characteristics, it would be a plus: Awareness of bioinformatic / computational methods supporting integrated analysis and interpretation of translational and biomarker-related data sets. Strong management skills, with the ability to prioritize and manage multiple objectives to meet timelines while maintaining attention to detail and high-performance standards. Experience adapting to fast-paced and evolving research environments, with strong problem-solving and critical-thinking skills. Work Location: This role is based in the United Kingdom or the United States and offers a hybrid working model, combining on-site and remote work flexibility. Join us in shaping the future of translational science and making a meaningful impact on patients' lives. • If you are based in Cambridge, MA; Waltham, MA; Rockville, MD; or San Francisco, CA, the annual base salary for new hires in this position ranges $189,750 to $316,250. The US salary ranges take into account a number of factors including work location within the US market, the candidate's skills, experience, education level and the market rate for the role. In addition, this position offers an annual bonus and eligibility to participate in our share based long term incentive program which is dependent on the level of the role. Available benefits include health care and other insurance benefits (for employee and family), retirement benefits, paid holidays, vacation, and paid caregiver/parental and medical leave. If salary ranges are not displayed in the job posting for a specific country, the relevant compensation will be discussed during the recruitment process. Why GSK? Uniting science, technology and talent to get ahead of disease together. GSK is a global biopharma company with a purpose to unite science, technology and talent to get ahead of disease together. We aim to positively impact the health of 2.5 billion people by the end of the decade, as a successful, growing company where people can thrive. We get ahead of disease by preventing and treating it with innovation in specialty medicines and vaccines. We focus on four therapeutic areas: respiratory, immunology and inflammation; oncology; HIV; and infectious diseases - to impact health at scale. People and patients around the world count on the medicines and vaccines we make, so we're committed to creating an environment where our people can thrive and focus on what matters most. Our culture of being ambitious for patients, accountable for impact and doing the right thing is the foundation for how, together, we deliver for patients, shareholders and our people. GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law. We believe in an agile working culture for all our roles. If flexibility is important to you, we encourage you to explore with our hiring team what the opportunities are. Should you require any adjustments to our process to assist you in demonstrating your strengths and capabilities contact us at where you can also request a call. Please note should your enquiry not relate to adjustments, we will not be able to support you through these channels. However, we have created a Recruitment FAQ guide. 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