Concept Life Sciences Group
Chapel-en-le-frith, Derbyshire
Concept Life Sciences is seeking an Associate Scientist/Scientist to join our in vitro ADME services team. Working as part of a collaborative team, you will be responsible for performing a wide range of ADME assays safely to a high standard. The role includes contributing to the design, execution, analysis, interpretation and quality control of studies across multiple ADME disciplines, including physicochemical profiles, drug metabolism and permeability. This is an exciting and diverse opportunity supporting the rapid growth and continued success to the ADME/DMPK team, working within our state-of-the-art laboratories at our Chapel-en-le-Frith site. What you will be doing: You will primarily be laboratory-based, conducting both routine and bespoke ADME assays to generate high-quality, reliable data. Working closely with Team Leaders, you will help organise, perform, process and review experimental work, ensuring projects are delivered efficiently and to a high scientific standard. The role involves running both low- and high-throughput automated assays, as well as supporting the development and optimisation of new assay methodologies. In addition, you will be responsible for the maintaining reagents and managing consumable stock levels. You will carry out routine maintenance and troubleshooting of LC-MS/MS and UV-LC systems, as well as Tecan robotic platforms, helping to maintain equipment performance and minimise downtime. Strong communication and collaboration skills are essential, as you will work closely with colleagues across the team. You will adhere strictly to health and safety regulations, SOPs and safe working practices, while maintaining a clean, organised and efficient laboratory environment. Development will be offered at every possible step, including internal mentorship and external seminars/conferences/courses, and innovation and independence are desired to contribute to this progression of our science and standards! About you: Theoretical knowledge and experience in performing in vitro ADME/DMPK assays Experience working within an ADME/DMPK laboratory environment Excellent written and verbal communication skills Confidence in scheduling, prioritising and managing studies and tasks, with a conscientious and deadline-driven approach Competent in the use of IT tools such as Microsoft Excel and WordA BSc or MSc in a relevant scientific discipline, or relevant industry experience within an ADME/DMPK lab Additional preferences: Experience in LC-MS/MS operation and maintenance (ideally Waters instrumentation) Experience using laboratory automation platforms such as Tecan robotics Experience in running permeability assays such as Caco-2 and MDCK Experience using ADME/DMPK data processing software What you will get: In addition to a competitive salary, we provide generous holiday entitlement, a pension scheme with enhanced employer contributions, a health cash plan covering a range of therapy treatments, a cycle to work scheme, a retail discount scheme, death in service benefit, a discretionary bonus scheme, and free on-site parking. You'll also have access to our BHN Extras platform, offering cashback, discounts, and tech/home purchases via salary sacrifice. Colleague wellbeing is important to us; we offer 24/7 virtual GP access, emotional support services, and a comprehensive wellbeing hub. We're proud of our inclusive, supportive culture and provide a range of learning and development opportunities to help you grow both personally and professionally. About Concept Life Sciences: Concept Life Sciences is a multi-disciplined Contract Research Organisation based in the UK providing market-leading scientific services globally. Over the past 25 years, Concept Life Sciences and its heritage companies have played a pivotal role in guiding numerous clients along their path to clinical success and many of these clients have evolved into enduring scientific collaborators. From our 4 sites across the UK, we provide world-leading expertise to the pharmaceutical, biotech, agrochemical, and material science industries. We have clients across Europe, Asia, and the US, who value our knowledge-based, science-led, and customer-focused approach.
Concept Life Sciences is seeking an Associate Scientist/Scientist to join our in vitro ADME services team. Working as part of a collaborative team, you will be responsible for performing a wide range of ADME assays safely to a high standard. The role includes contributing to the design, execution, analysis, interpretation and quality control of studies across multiple ADME disciplines, including physicochemical profiles, drug metabolism and permeability. This is an exciting and diverse opportunity supporting the rapid growth and continued success to the ADME/DMPK team, working within our state-of-the-art laboratories at our Chapel-en-le-Frith site. What you will be doing: You will primarily be laboratory-based, conducting both routine and bespoke ADME assays to generate high-quality, reliable data. Working closely with Team Leaders, you will help organise, perform, process and review experimental work, ensuring projects are delivered efficiently and to a high scientific standard. The role involves running both low- and high-throughput automated assays, as well as supporting the development and optimisation of new assay methodologies. In addition, you will be responsible for the maintaining reagents and managing consumable stock levels. You will carry out routine maintenance and troubleshooting of LC-MS/MS and UV-LC systems, as well as Tecan robotic platforms, helping to maintain equipment performance and minimise downtime. Strong communication and collaboration skills are essential, as you will work closely with colleagues across the team. You will adhere strictly to health and safety regulations, SOPs and safe working practices, while maintaining a clean, organised and efficient laboratory environment. Development will be offered at every possible step, including internal mentorship and external seminars/conferences/courses, and innovation and independence are desired to contribute to this progression of our science and standards! About you: Theoretical knowledge and experience in performing in vitro ADME/DMPK assays Experience working within an ADME/DMPK laboratory environment Excellent written and verbal communication skills Confidence in scheduling, prioritising and managing studies and tasks, with a conscientious and deadline-driven approach Competent in the use of IT tools such as Microsoft Excel and WordA BSc or MSc in a relevant scientific discipline, or relevant industry experience within an ADME/DMPK lab Additional preferences: Experience in LC-MS/MS operation and maintenance (ideally Waters instrumentation) Experience using laboratory automation platforms such as Tecan robotics Experience in running permeability assays such as Caco-2 and MDCK Experience using ADME/DMPK data processing software What you will get: In addition to a competitive salary, we provide generous holiday entitlement, a pension scheme with enhanced employer contributions, a health cash plan covering a range of therapy treatments, a cycle to work scheme, a retail discount scheme, death in service benefit, a discretionary bonus scheme, and free on-site parking. You'll also have access to our BHN Extras platform, offering cashback, discounts, and tech/home purchases via salary sacrifice. Colleague wellbeing is important to us; we offer 24/7 virtual GP access, emotional support services, and a comprehensive wellbeing hub. We're proud of our inclusive, supportive culture and provide a range of learning and development opportunities to help you grow both personally and professionally. About Concept Life Sciences: Concept Life Sciences is a multi-disciplined Contract Research Organisation based in the UK providing market-leading scientific services globally. Over the past 25 years, Concept Life Sciences and its heritage companies have played a pivotal role in guiding numerous clients along their path to clinical success and many of these clients have evolved into enduring scientific collaborators. From our 4 sites across the UK, we provide world-leading expertise to the pharmaceutical, biotech, agrochemical, and material science industries. We have clients across Europe, Asia, and the US, who value our knowledge-based, science-led, and customer-focused approach.
Concept Life Sciences Group
Chapel-en-le-frith, Derbyshire
Senior Bioanalytical ADME/DMPK Scientist Job Role: Senior Bioanalytical ADME/DMPK Scientist Site: Chapel-en-le-Frith Salary: up to £40,000 p/a Concept Life Sciences seeks a Senior Bioanalytical ADME/DMPK Scientist to primarily assist with discovery bioanalysis and PK/PD analyses, whilst supporting all functions of the ADME/DMPK team, including potential cross-functionality across in vitro ADME assays. This exciting diverse role will support the rapid growth and continued success of the ADME/DMPK team, utilising the new state of the art laboratories at our Chapel en le Frith site. What you will be doing: You will work closely with our Team Leaders, designing, organising, performing, processing, reviewing and reporting studies, engaging with clients and other departments across our sites, and contributing to process improvement during the expansion of the team's capacity and capabilities. This role will be laboratory based primarily but will have a lot of input into how bioanalysis and PK/PD analysis is performed, including influence over systems and processes, vendors, consumables, instruments and equipment. Development will be offered at every possible step, including internal mentorship and external seminars/conferences/courses, and innovation and independence are desired to contribute to this progression of our science and standards! About you: You are an independent and self motivated, experienced Scientist, with extensive bioanalytical experience, including method development and sample analysis across a variety of molecules, matrices and extraction methods (small molecules, peptides, prodrugs; plasma, blood, brain, heart; PPT, SPE, LLE). You have experience processing, interpreting and troubleshooting bioanalytical and PK/PD data, utilising Excel and Phoenix WinNonLin software. You are adept at using, maintaining, and troubleshooting LC MS/MS, and potentially UV LC systems, ideally Waters instruments and associated software (MassLynx, TargetLynx, Trendplot). You will understand in life study design and be able to contribute to discussions regarding study variables and how they will impact outcomes, to inform client decisions You have excellent written and verbal communication skills; you will be comfortable reporting and presenting your research to colleagues and clients alike. You are confident scheduling, prioritising and delegating studies and tasks, and have a punctual conscientious disposition towards deadlines You will have a B.Sc. or M.Sc. in a relevant field. Additional preferences: DMPK experience as a project representative or otherwise In vitro ADME assay experience; performing, processing and reporting High resolution MS operation and troubleshooting experience Metabolite Identification experience What you will get: In addition to a competitive salary, we provide generous holiday entitlement, a pension scheme with enhanced employer contributions, a health cash plan covering a range of therapy treatments, a cycle to work scheme, a retail discount scheme, death in service benefit, a discretionary bonus scheme, and free on site parking. You'll also have access to our BHN Extras platform, offering cashback, discounts, and tech/home purchases via salary sacrifice. Colleague wellbeing is important to us; we offer 24/7 virtual GP access, emotional support services, and a comprehensive wellbeing hub. We're proud of our inclusive, supportive culture and provide a range of learning and development opportunities to help you grow both personally and professionally. About Concept Life Sciences: Concept Life Sciences is a multi disciplined Contract Research Organisation based in the UK providing market leading scientific services globally. Over the past 25 years, Concept Life Sciences and its heritage companies have played a pivotal role in guiding numerous clients along their path to clinical success and many of these clients have evolved into enduring scientific collaborators. From our 4 sites across the UK, we provide world leading expertise to the pharmaceutical, biotech, agrochemical, and material science industries. We have clients across Europe, Asia, and the US, who value our knowledge based, science led, and customer focused approach.
Senior Bioanalytical ADME/DMPK Scientist Job Role: Senior Bioanalytical ADME/DMPK Scientist Site: Chapel-en-le-Frith Salary: up to £40,000 p/a Concept Life Sciences seeks a Senior Bioanalytical ADME/DMPK Scientist to primarily assist with discovery bioanalysis and PK/PD analyses, whilst supporting all functions of the ADME/DMPK team, including potential cross-functionality across in vitro ADME assays. This exciting diverse role will support the rapid growth and continued success of the ADME/DMPK team, utilising the new state of the art laboratories at our Chapel en le Frith site. What you will be doing: You will work closely with our Team Leaders, designing, organising, performing, processing, reviewing and reporting studies, engaging with clients and other departments across our sites, and contributing to process improvement during the expansion of the team's capacity and capabilities. This role will be laboratory based primarily but will have a lot of input into how bioanalysis and PK/PD analysis is performed, including influence over systems and processes, vendors, consumables, instruments and equipment. Development will be offered at every possible step, including internal mentorship and external seminars/conferences/courses, and innovation and independence are desired to contribute to this progression of our science and standards! About you: You are an independent and self motivated, experienced Scientist, with extensive bioanalytical experience, including method development and sample analysis across a variety of molecules, matrices and extraction methods (small molecules, peptides, prodrugs; plasma, blood, brain, heart; PPT, SPE, LLE). You have experience processing, interpreting and troubleshooting bioanalytical and PK/PD data, utilising Excel and Phoenix WinNonLin software. You are adept at using, maintaining, and troubleshooting LC MS/MS, and potentially UV LC systems, ideally Waters instruments and associated software (MassLynx, TargetLynx, Trendplot). You will understand in life study design and be able to contribute to discussions regarding study variables and how they will impact outcomes, to inform client decisions You have excellent written and verbal communication skills; you will be comfortable reporting and presenting your research to colleagues and clients alike. You are confident scheduling, prioritising and delegating studies and tasks, and have a punctual conscientious disposition towards deadlines You will have a B.Sc. or M.Sc. in a relevant field. Additional preferences: DMPK experience as a project representative or otherwise In vitro ADME assay experience; performing, processing and reporting High resolution MS operation and troubleshooting experience Metabolite Identification experience What you will get: In addition to a competitive salary, we provide generous holiday entitlement, a pension scheme with enhanced employer contributions, a health cash plan covering a range of therapy treatments, a cycle to work scheme, a retail discount scheme, death in service benefit, a discretionary bonus scheme, and free on site parking. You'll also have access to our BHN Extras platform, offering cashback, discounts, and tech/home purchases via salary sacrifice. Colleague wellbeing is important to us; we offer 24/7 virtual GP access, emotional support services, and a comprehensive wellbeing hub. We're proud of our inclusive, supportive culture and provide a range of learning and development opportunities to help you grow both personally and professionally. About Concept Life Sciences: Concept Life Sciences is a multi disciplined Contract Research Organisation based in the UK providing market leading scientific services globally. Over the past 25 years, Concept Life Sciences and its heritage companies have played a pivotal role in guiding numerous clients along their path to clinical success and many of these clients have evolved into enduring scientific collaborators. From our 4 sites across the UK, we provide world leading expertise to the pharmaceutical, biotech, agrochemical, and material science industries. We have clients across Europe, Asia, and the US, who value our knowledge based, science led, and customer focused approach.