relationrx

Senior Scientist CRISPR R&D - Functional Genomics London About Relation Relation is an end-to-end biotech developing transformational medicines, with technology at our core. Our ambition is to understand human biology in unprecedented ways, discovering therapies to treat some of life's most devastating diseases. We leverage single-cell multi-omics directly from patient tissue, functional assays, and machine learning to drive disease understanding, from cause to cure. This year, we've embarked on an exciting double collaboration with GSK to tackle fibrosis and osteoarthritis, alongside advancing our own internal osteoporosis programme. By combining our cutting-edge ML capabilities with their deep expertise in drug discovery, this partnership underscores our commitment to pioneering science and delivering impactful therapies to patients. We are rapidly scaling our technology and discovery teams, offering a unique opportunity to join one of the most innovative TechBio companies. Be part of our dynamic, interdisciplinary teams, collaborating closely to redefine the boundaries of possibility in drug discovery. Our state-of-the-art wet and dry laboratories, located in the heart of London, provide an exceptional environment to foster interdisciplinarity and turn groundbreaking ideas into positive impact for patients. We are committed to building diverse and inclusive teams. Relation is an equal opportunities employer and does not discriminate on the grounds of gender, sexual orientation, marital or civil partner status, gender reassignment, race, colour, nationality, ethnic or national origin, religion or belief, disability, or age. We cultivate innovation through collaboration, empowering every team member to do their best work and develop to their highest potential. By joining Relation, you will be part of an exceptionally talented team, with extraordinary leverage to advance the field of drug discovery. Your work will shape our culture, strategic direction, and, most importantly, impact patients' lives. The Opportunity Relation has an excellent opportunity for a Senior Scientist to join an interdisciplinary, highly collaborative team of experimental and computational drug discovery researchers in our newly built, state-of-the-art functional genomics lab in London. Large-scale genetic studies, including genome-wide association studies (GWAS), have identified thousands of variants and loci associated with complex diseases. However, the vast majority of these loci lie in non-coding regions of the genome with unknown functions, making it challenging to draw disease insights. At Relation, we generate proprietary large-scale datasets to accelerate the prediction of disease genes from these loci using state-of-the-art machine learning methods. We identify the key effector genes, cells, and pathways involved in disease pathophysiology to build disease-relevant assays and validate ML platform predictions, identifying candidate targets for further validation. We have an exciting opportunity for a talented Senior Scientist to contribute intellectually and experimentally to this endeavour. By joining Relation, you will be part of an exceptionally talented team, gain exposure to a broad range of skills beyond your area of expertise, help shape our culture and strategic direction, and ultimately, make a positive impact on patients' lives. As the company grows rapidly, there may be opportunities to supervise a small team. Professionally, you have A PhD with at least 3 years of experience and an outstanding track record in academia, biotech or pharma. At least 2 years' hands-on experience with all aspects of CRISPR technology (including CRISPRn, CRISPRi, CRISPRa, Cas9 and derivatives, Cas13). Extensive experience with mammalian cell transduction using lentiviral particles, cell transfection, lipofection, and nucleofection. Extensive experience with molecular cloning and mammalian cell engineering (TOPO, Gateway, Gibson, Golden Gate, reporter systems). Experience with flow cytometry and cell sorting. Broad experience with standard molecular biology techniques. A proven ability to deliver to tight timelines. Desirable knowledge or experiences Experience with siRNA, ASO, and other interventions for protein function modulation. Experience with assay development, screening, and liquid handling. Experience of interdisciplinary team-working, especially with computational scientists. Personally, you have A willingness to operate within start-up environments, including delivering to tight timelines, the ability to react to changing priorities or plans, and to help with laboratory operations. Excellent attention to detail, analytical, and critical thinking skills An ability to build effective working relationships with proven team-working skills An ability to communicate effectively with scientists from multiple disciplines An inquisitive nature, are self-motivated, and eager to learn A desire to work within a fast-paced, data science-first environment. Join Us This is an exciting opportunity to be part of a company that is redefining how we understand genetics and disease risk. Your contributions will directly impact the development of transformative medicines for patients. Together, we're not just conducting research-we're setting new standards in machine learning and genetics. The patient is waiting. Relation is a committed equal opportunities employer. Recruitment Agencies Please note that Relation does not accept unsolicited resumes from agencies. Resumes should not be forwarded to our job aliases or employees. Relation will not be liable for any fees associated with unsolicited CVs.