Exogene Ltd.
Oxford, Oxfordshire
About Exogene At Exogene, we're reimagining what's possible in cancer immunotherapy. Our mission is to engineer T-cell receptor therapies that can precisely and powerfully target advanced, difficult-to-treat, solid tumours. To do this, we've built a proprietary lab-in-the-loop platform that merges generative AI, biophysical modelling, and high-throughput TCR screening to rapidly design, test, and optimise TCRs with exceptional affinity and specificity. This convergence of computation and wet-lab experimentation allows us to go from concept to candidate molecules in record time. Using our lab-in-the-loop platform, we're developing TCR-based trispecific T cell engagers (TCR-TriTCEs) , a new therapeutic modality designed to overcome the unique challenges of the solid tumour microenvironment. This work spans multiple disciplines, from protein engineering and AI-driven design to in vivo validation and translational development. We are seeking a visionary and highly experienced Head of Pre-clinical Development to lead our innovative TCR-TriTCE pipeline from early discovery through to IND-enabling studies. This is a critical leadership role that will manage our dedicated lab team, shape our scientific strategy, and play a pivotal role in Exogene's growth. You will interact directly with our founders on scientific planning, business development, and fundraising initiatives. The opportunity As our Head of Pre-clinical Development, you will be instrumental in translating our cutting-edge AI-discovered TCRs into clinical candidates. You will lead and mentor a talented team, drive the overall pre-clinical drug development pipeline, and ensure our assets are robustly validated and ready for first-in-human studies. Responsibilities Strategic Planning : Set and execute the comprehensive in vivo and in vitro validation strategy for our TCR-based trispecific T cell engagers (TCR-TriTCEs), covering safety, efficacy, developability and full PK/PD characterisation. Developability & Manufacturability :Oversee all developability assessments, including stability, aggregation, manufacturability, and immunogenicity risk, to ensure our TCR-TriTCE candidates can be scaled efficiently and safely to GMP. CRO Oversight :Design and rigorously oversee all lead optimisation and IND-enabling studies. Effectively manage interactions and relationships with Contract Research Organisations (CROs) to ensure high-quality, timely execution. Team Leadership :Provide strong scientific and operational leadership to the pre-clinical lab team, fostering a culture of innovation, collaboration, and scientific rigor. External Relations :Liaise closely with Exogene founders on scientific planning, contribute to business development initiatives, and support fundraising efforts. Skills and Qualifications PhD in Immunology, Cell Biology, Biochemistry, Pharmacology, or a closely related field. 8+ years of progressive industry experience in biopharmaceutical pre-clinical drug development, with a significant portion dedicated to biologics (T cell engagers, antibodies or any other protein-based therapeutics). Demonstrated track record of successfully guiding novel drug candidates from discovery to lead optimisation and through to IND-enabling studies. Experience with submitting and supporting INDs is highly desirable. Proven expertise in designing, executing, and interpreting in vivo and in vitro pharmacology studies (efficacy, PK/PD, safety/toxicology) for biologics. Deep understanding and practical experience with developability assessments (stability, aggregation, manufacturability, immunogenicity risk). Strong experience in managing and collaborating with CROs for key pre-clinical studies. Excellent leadership and team management skills, with prior experience in mentoring and developing scientific talent. Exceptional written and oral communication skills, with the ability to articulate complex scientific concepts to diverse audiences, including internal teams, founders, potential partners, and investors. Proven ability to run effective cross-functional data review processes and ensure rigorous documentation standards for regulatory readiness. Experience with T-cell immunology, TCRs, or T-cell engagers is a significant advantage. Strong commercial understanding of the T cell engager landscape and peptide-HLA target space is highly desirable. Familiarity with AI/ML integration in drug discovery is a plus. Attributes A strategic thinker with a strong scientific vision and the ability to translate strategic goals into actionable pre-clinical plans. Highly collaborative, capable of building strong relationships across internal functions and with external partners. Inspirational lab leader and mentor who empowers multidisciplinary bench scientists, cultivating rigorous science and continuous learning. Results-oriented with a strong sense of urgency and accountability. A proactive problem-solver with exceptional analytical skills and attention to detail. Adaptable and resilient in a fast-paced, evolving start-up environment. Passion for Exogene's mission to revolutionise cancer immunotherapy. What We Offer Market-competitive salary and stock option package. A generous leave policy: 25 days holiday, public holidays, plus a day off for your birthday! Access to fully equipped private lab in Oxford. Flexibility to work from home as project demands allow. A supportive, cross-disciplinary team fostering a highly collaborative work environment. How to apply Please send your CV and cover letter (max 400 words) to m.hasan at exogene.co.uk
About Exogene At Exogene, we're reimagining what's possible in cancer immunotherapy. Our mission is to engineer T-cell receptor therapies that can precisely and powerfully target advanced, difficult-to-treat, solid tumours. To do this, we've built a proprietary lab-in-the-loop platform that merges generative AI, biophysical modelling, and high-throughput TCR screening to rapidly design, test, and optimise TCRs with exceptional affinity and specificity. This convergence of computation and wet-lab experimentation allows us to go from concept to candidate molecules in record time. Using our lab-in-the-loop platform, we're developing TCR-based trispecific T cell engagers (TCR-TriTCEs) , a new therapeutic modality designed to overcome the unique challenges of the solid tumour microenvironment. This work spans multiple disciplines, from protein engineering and AI-driven design to in vivo validation and translational development. We are seeking a visionary and highly experienced Head of Pre-clinical Development to lead our innovative TCR-TriTCE pipeline from early discovery through to IND-enabling studies. This is a critical leadership role that will manage our dedicated lab team, shape our scientific strategy, and play a pivotal role in Exogene's growth. You will interact directly with our founders on scientific planning, business development, and fundraising initiatives. The opportunity As our Head of Pre-clinical Development, you will be instrumental in translating our cutting-edge AI-discovered TCRs into clinical candidates. You will lead and mentor a talented team, drive the overall pre-clinical drug development pipeline, and ensure our assets are robustly validated and ready for first-in-human studies. Responsibilities Strategic Planning : Set and execute the comprehensive in vivo and in vitro validation strategy for our TCR-based trispecific T cell engagers (TCR-TriTCEs), covering safety, efficacy, developability and full PK/PD characterisation. Developability & Manufacturability :Oversee all developability assessments, including stability, aggregation, manufacturability, and immunogenicity risk, to ensure our TCR-TriTCE candidates can be scaled efficiently and safely to GMP. CRO Oversight :Design and rigorously oversee all lead optimisation and IND-enabling studies. Effectively manage interactions and relationships with Contract Research Organisations (CROs) to ensure high-quality, timely execution. Team Leadership :Provide strong scientific and operational leadership to the pre-clinical lab team, fostering a culture of innovation, collaboration, and scientific rigor. External Relations :Liaise closely with Exogene founders on scientific planning, contribute to business development initiatives, and support fundraising efforts. Skills and Qualifications PhD in Immunology, Cell Biology, Biochemistry, Pharmacology, or a closely related field. 8+ years of progressive industry experience in biopharmaceutical pre-clinical drug development, with a significant portion dedicated to biologics (T cell engagers, antibodies or any other protein-based therapeutics). Demonstrated track record of successfully guiding novel drug candidates from discovery to lead optimisation and through to IND-enabling studies. Experience with submitting and supporting INDs is highly desirable. Proven expertise in designing, executing, and interpreting in vivo and in vitro pharmacology studies (efficacy, PK/PD, safety/toxicology) for biologics. Deep understanding and practical experience with developability assessments (stability, aggregation, manufacturability, immunogenicity risk). Strong experience in managing and collaborating with CROs for key pre-clinical studies. Excellent leadership and team management skills, with prior experience in mentoring and developing scientific talent. Exceptional written and oral communication skills, with the ability to articulate complex scientific concepts to diverse audiences, including internal teams, founders, potential partners, and investors. Proven ability to run effective cross-functional data review processes and ensure rigorous documentation standards for regulatory readiness. Experience with T-cell immunology, TCRs, or T-cell engagers is a significant advantage. Strong commercial understanding of the T cell engager landscape and peptide-HLA target space is highly desirable. Familiarity with AI/ML integration in drug discovery is a plus. Attributes A strategic thinker with a strong scientific vision and the ability to translate strategic goals into actionable pre-clinical plans. Highly collaborative, capable of building strong relationships across internal functions and with external partners. Inspirational lab leader and mentor who empowers multidisciplinary bench scientists, cultivating rigorous science and continuous learning. Results-oriented with a strong sense of urgency and accountability. A proactive problem-solver with exceptional analytical skills and attention to detail. Adaptable and resilient in a fast-paced, evolving start-up environment. Passion for Exogene's mission to revolutionise cancer immunotherapy. What We Offer Market-competitive salary and stock option package. A generous leave policy: 25 days holiday, public holidays, plus a day off for your birthday! Access to fully equipped private lab in Oxford. Flexibility to work from home as project demands allow. A supportive, cross-disciplinary team fostering a highly collaborative work environment. How to apply Please send your CV and cover letter (max 400 words) to m.hasan at exogene.co.uk
Exogene Ltd.
Oxford, Oxfordshire
About Exogene At Exogene, we're reimagining what's possible in cancer immunotherapy. Our mission is to engineer T-cell receptor therapies that can precisely and powerfully target solid tumours-diseases long considered out of reach for conventional immunotherapies. To do this, we've built a proprietary lab-in-the-loop platform that merges generative AI, biophysical modelling, and high-throughput TCR screening to rapidly design, test, and optimise TCRs with exceptional affinity and specificity. This convergence of computation and wet-lab experimentation allows us to go from concept to candidate molecules in record time. We're developing trispecific TCR-based T cell engagers (TCR-TriTCEs) -a new therapeutic modality designed to overcome the unique challenges of the solid tumour microenvironment. This work spans multiple disciplines, from protein engineering and AI-driven design to in vivo validation and translational development. We are looking for a dynamic senior or principal scientist who will help drive the TCR engineering processes and development. The successful candidate will leadin vivo andin vitrovalidation of TCEs. You'll get involved in purifying recombinant TCRs to perform high-throughput TCR display methods and deep sequencing. Responsibilities Lead in vivo and in vitro validation of TCEs. Collaboratively design and characterise TCRs for proprietary and partnered disease targets. Conduct a suite of protein science operations, including expression, purification, and biophysical analysis. Tackle molecular biology duties: cloning, mutagenesis, DNA isolation, and preparing libraries for deep sequencing. Manage tissue culture assignments, spanning from media prep and cell line care to cryopreservation. Join forces with founders, R&D, academia, and industrial stakeholders to fulfil ambitious R&D objectives. Draft, revise, and oversee repertoire of lab protocols. Offer essential lab support and uphold facility upkeep. Skills and Qualifications PhD in Immunology, Cell Biology, Biochemistry, or an alike field, paired with at least 1-2 years of relevant lab experience is required. For senior scientist we are looking for over 3 years industry experience. Experience in in vivo and in vitro validation of TCEs (T-cell engagers) all the way though to investigational new drug (IND) approval is critical. Knowledge of molecular biology protocols, with an emphasis on cloning and PCR is preferred. A background in protein expression, purification and biophysical characterisation is preferred. Experience in cell and immunological assays (flow cytometry, ELISA etc.) is desired. Experience in NGS analysis pipeline (specifically data analysis using software such as R) is desired. SOP documentation experience is desired. The highest standards in lab precision, record maintenance, and documentation. Excellent written and oral communication skills. Attributes Self-starter with sound analytical skills, who values scientific integrity and novelty. Collaborative spirit within the lab, open to both giving and receiving actionable feedback. Exceptional at diagnosing and overcoming unforeseen technical challenges. Adept at juggling and prioritising multiple projects to meet deadlines. Versatile and efficient within an interdisciplinary, fast-paced team setup. What We Offer Market-competitive salary and stock option package. A generous leave policy: 25 days holiday, public holidays, plus a day off for your birthday! Access to fully equipped private lab. Flexibility to work from home as project demands allow. A supportive, cross-disciplinary team fostering a highly collaborative work environment. How to apply Please send your CV and cover letter (max 400 words) to m.hasan at exogene.co.uk
About Exogene At Exogene, we're reimagining what's possible in cancer immunotherapy. Our mission is to engineer T-cell receptor therapies that can precisely and powerfully target solid tumours-diseases long considered out of reach for conventional immunotherapies. To do this, we've built a proprietary lab-in-the-loop platform that merges generative AI, biophysical modelling, and high-throughput TCR screening to rapidly design, test, and optimise TCRs with exceptional affinity and specificity. This convergence of computation and wet-lab experimentation allows us to go from concept to candidate molecules in record time. We're developing trispecific TCR-based T cell engagers (TCR-TriTCEs) -a new therapeutic modality designed to overcome the unique challenges of the solid tumour microenvironment. This work spans multiple disciplines, from protein engineering and AI-driven design to in vivo validation and translational development. We are looking for a dynamic senior or principal scientist who will help drive the TCR engineering processes and development. The successful candidate will leadin vivo andin vitrovalidation of TCEs. You'll get involved in purifying recombinant TCRs to perform high-throughput TCR display methods and deep sequencing. Responsibilities Lead in vivo and in vitro validation of TCEs. Collaboratively design and characterise TCRs for proprietary and partnered disease targets. Conduct a suite of protein science operations, including expression, purification, and biophysical analysis. Tackle molecular biology duties: cloning, mutagenesis, DNA isolation, and preparing libraries for deep sequencing. Manage tissue culture assignments, spanning from media prep and cell line care to cryopreservation. Join forces with founders, R&D, academia, and industrial stakeholders to fulfil ambitious R&D objectives. Draft, revise, and oversee repertoire of lab protocols. Offer essential lab support and uphold facility upkeep. Skills and Qualifications PhD in Immunology, Cell Biology, Biochemistry, or an alike field, paired with at least 1-2 years of relevant lab experience is required. For senior scientist we are looking for over 3 years industry experience. Experience in in vivo and in vitro validation of TCEs (T-cell engagers) all the way though to investigational new drug (IND) approval is critical. Knowledge of molecular biology protocols, with an emphasis on cloning and PCR is preferred. A background in protein expression, purification and biophysical characterisation is preferred. Experience in cell and immunological assays (flow cytometry, ELISA etc.) is desired. Experience in NGS analysis pipeline (specifically data analysis using software such as R) is desired. SOP documentation experience is desired. The highest standards in lab precision, record maintenance, and documentation. Excellent written and oral communication skills. Attributes Self-starter with sound analytical skills, who values scientific integrity and novelty. Collaborative spirit within the lab, open to both giving and receiving actionable feedback. Exceptional at diagnosing and overcoming unforeseen technical challenges. Adept at juggling and prioritising multiple projects to meet deadlines. Versatile and efficient within an interdisciplinary, fast-paced team setup. What We Offer Market-competitive salary and stock option package. A generous leave policy: 25 days holiday, public holidays, plus a day off for your birthday! Access to fully equipped private lab. Flexibility to work from home as project demands allow. A supportive, cross-disciplinary team fostering a highly collaborative work environment. How to apply Please send your CV and cover letter (max 400 words) to m.hasan at exogene.co.uk