Our Mission Our mission is to restore cell health and resilience through cell rejuvenation to reverse disease, injury, and the disabilities that can occur throughout life. For more information, see our website at Our Value Our Single Altos Value: Everyone Owns Achieving Our Inspiring Mission. Diversity at Altos We believe that diverse perspectives are foundational to scientific innovation and inquiry. At Altos, exceptional scientists and industry leaders from around the world work together to advance a shared mission. Our intentional focus is on Belonging, so that all employees know that they are valued for their unique perspectives. We are all accountable for sustaining a diverse and inclusive environment. What You Will Contribute To Altos The Altos Labs Institute of Computation (IoC) is seeking an independent and highly motivated Computational Biology Scientist to build, maintain, and support our hybrid AI initiative to model cellular processes. The position will work in a multi-disciplinary research environment to assist investigators in algorithm development and implementation, and will work across the software development life cycle, including software design, coding, testing, deployment, and maintenance. The ideal candidate will be a good communicator and have a growth mindset with an enthusiasm for scientific discovery and strong interest in applying a combination of AI methods and mathematical models toward understanding mechanistic aspects of cellular processes with all experimental labs at Altos Labs. The ideal candidate is particularly interested in multi-scale (systems) biochemistry and molecular biology of reprogramming, a dynamic field that seeks to understand complex biological systems by integrating data about biochemical components and help design interventions that direct cellular states along desired trajectories. This includes working with quantitative "big data" and building predictive models to develop novel theories. Our ultimate goal is to contribute to improving human lives through better-informed treatments. Responsibilities: - Contribute to modeling, simulation, and analysis of mechanistic or data-driven models of biological processes through software development in a highly collaborative environment. This will include: - Exploring and developing ML algorithms to solve complex problems and draw conclusions. Apply state of the art AI tools to infer and model cellular dynamics from large data sets Applying strong coding experience to model development using existing languages(s) and framework(s) Using AI as a tool to answer a scientific question, involved in the research and development aspects - Design and implement pipelines to mechanistically model cellular processes from model instantiation to simulation, calibration, and analysis. Collaborate with other scientists to characterize model behaviors, predictions, refinements, and accelerate the biological knowledge discovery. Developing research programs on partial cellular reprogramming, with the intent of closing the feedback loop between experimental and theoretical work, at multiple scales, from molecules to cells, tissues and even whole organisms. Working at the interface between mathematical and computational models, and AI methods, with the aim of establishing design principles of rejuvenated cells. Collaborating with both experimental and computational scientists across Altos. Influence best practices in areas such as Bayesian optimization, causal inference, building and assessing predictive models, analyzing biological networks, and analysis and visualization of -omics data. Maintain documentation and keep up-to-date as needed. Contribute to software releases (e.g. via GitHub, PyPI, Anaconda, Docker Hub). Who You Are The ideal candidate will be a strong collaborator with a background in dynamical systems and mathematical modeling of biological systems. Be able to demonstrate significant AI experience / application in conjunction with a working understanding of cell biology and/or biophysics. The level of the position will depend on the qualifications of the selected candidate. Minimum Qualifications - PhD in Biology, Computational Biology, Computer Science, or closely related field with strong emphasis in biological modeling. Relevant industry and/or academic experience. Expertise and a track record of using methods from artificial intelligence for biological design. Record of applications of dynamical systems to problems of synthetic biology. Record of applications of data driven modeling methods and AI to synthetic biology. Demonstrable experience of developing new statistical and machine learning-based methods for analyzing biological data to produce biological insights about cell health and rejuvenation. Experience working with mechanistic models (PDE/ODE, SDE, dynamical systems). Experience working with state of the art ML tools (transformers, GNN, etc.) Experience working with hybrid AI models (e.g., SINDy) Working knowledge of cell biology. Experience with Python, C, R or related scientific computing languages. Preferred Qualifications - Experience working with causal representation learning Experience with RAG (retrieval-augmented generation) and GraphRAG a big plus Experience with building and deploying software on GitHub, PyPI, Anaconda Cloud, and Docker Hub, as well as use of Pytorch lightning, Git, test-driven design. Knowledge of parallel computing technologies, such as NVIDIA's CUDA platform, OpenCL, and OpenMPI. The salary range for Cambridge, UK: - Senior Scientist I, Computational Biology: £75,000 - £117,500 Senior Scientist II, Computational Biology: £94,000 - £152,500 Exact compensation may vary based on skills, experience, and location.
Oct 01, 2025
Full time
Our Mission Our mission is to restore cell health and resilience through cell rejuvenation to reverse disease, injury, and the disabilities that can occur throughout life. For more information, see our website at Our Value Our Single Altos Value: Everyone Owns Achieving Our Inspiring Mission. Diversity at Altos We believe that diverse perspectives are foundational to scientific innovation and inquiry. At Altos, exceptional scientists and industry leaders from around the world work together to advance a shared mission. Our intentional focus is on Belonging, so that all employees know that they are valued for their unique perspectives. We are all accountable for sustaining a diverse and inclusive environment. What You Will Contribute To Altos The Altos Labs Institute of Computation (IoC) is seeking an independent and highly motivated Computational Biology Scientist to build, maintain, and support our hybrid AI initiative to model cellular processes. The position will work in a multi-disciplinary research environment to assist investigators in algorithm development and implementation, and will work across the software development life cycle, including software design, coding, testing, deployment, and maintenance. The ideal candidate will be a good communicator and have a growth mindset with an enthusiasm for scientific discovery and strong interest in applying a combination of AI methods and mathematical models toward understanding mechanistic aspects of cellular processes with all experimental labs at Altos Labs. The ideal candidate is particularly interested in multi-scale (systems) biochemistry and molecular biology of reprogramming, a dynamic field that seeks to understand complex biological systems by integrating data about biochemical components and help design interventions that direct cellular states along desired trajectories. This includes working with quantitative "big data" and building predictive models to develop novel theories. Our ultimate goal is to contribute to improving human lives through better-informed treatments. Responsibilities: - Contribute to modeling, simulation, and analysis of mechanistic or data-driven models of biological processes through software development in a highly collaborative environment. This will include: - Exploring and developing ML algorithms to solve complex problems and draw conclusions. Apply state of the art AI tools to infer and model cellular dynamics from large data sets Applying strong coding experience to model development using existing languages(s) and framework(s) Using AI as a tool to answer a scientific question, involved in the research and development aspects - Design and implement pipelines to mechanistically model cellular processes from model instantiation to simulation, calibration, and analysis. Collaborate with other scientists to characterize model behaviors, predictions, refinements, and accelerate the biological knowledge discovery. Developing research programs on partial cellular reprogramming, with the intent of closing the feedback loop between experimental and theoretical work, at multiple scales, from molecules to cells, tissues and even whole organisms. Working at the interface between mathematical and computational models, and AI methods, with the aim of establishing design principles of rejuvenated cells. Collaborating with both experimental and computational scientists across Altos. Influence best practices in areas such as Bayesian optimization, causal inference, building and assessing predictive models, analyzing biological networks, and analysis and visualization of -omics data. Maintain documentation and keep up-to-date as needed. Contribute to software releases (e.g. via GitHub, PyPI, Anaconda, Docker Hub). Who You Are The ideal candidate will be a strong collaborator with a background in dynamical systems and mathematical modeling of biological systems. Be able to demonstrate significant AI experience / application in conjunction with a working understanding of cell biology and/or biophysics. The level of the position will depend on the qualifications of the selected candidate. Minimum Qualifications - PhD in Biology, Computational Biology, Computer Science, or closely related field with strong emphasis in biological modeling. Relevant industry and/or academic experience. Expertise and a track record of using methods from artificial intelligence for biological design. Record of applications of dynamical systems to problems of synthetic biology. Record of applications of data driven modeling methods and AI to synthetic biology. Demonstrable experience of developing new statistical and machine learning-based methods for analyzing biological data to produce biological insights about cell health and rejuvenation. Experience working with mechanistic models (PDE/ODE, SDE, dynamical systems). Experience working with state of the art ML tools (transformers, GNN, etc.) Experience working with hybrid AI models (e.g., SINDy) Working knowledge of cell biology. Experience with Python, C, R or related scientific computing languages. Preferred Qualifications - Experience working with causal representation learning Experience with RAG (retrieval-augmented generation) and GraphRAG a big plus Experience with building and deploying software on GitHub, PyPI, Anaconda Cloud, and Docker Hub, as well as use of Pytorch lightning, Git, test-driven design. Knowledge of parallel computing technologies, such as NVIDIA's CUDA platform, OpenCL, and OpenMPI. The salary range for Cambridge, UK: - Senior Scientist I, Computational Biology: £75,000 - £117,500 Senior Scientist II, Computational Biology: £94,000 - £152,500 Exact compensation may vary based on skills, experience, and location.
Director, Environmental, Health and Safety (EHS) Our mission is to restore cell health and resilience through cell rejuvenation to reverse disease, injury, and the disabilities that can occur throughout life. For more information, see our website at Our Single Altos Value: Everyone Owns Achieving Our Inspiring Mission. We believe that diverse perspectives are foundational to scientific innovation and inquiry. At Altos, exceptional scientists and industry leaders from around the world work together to advance a shared mission. Our intentional focus is on Belonging, so that all employees know that they are valued for their unique perspectives. We are all accountable for sustaining a diverse and inclusive environment. As a key member of our Global Compliance Team, the Director, EHS, Cambridge Institute (CI), is responsible for developing, implementing, and sustaining EHS improvement programs and policies for the laboratories and support functions at Altos' Cambridge Institute. The programs focus on preventing occupational injuries and illnesses, identifying and mitigating operational hazards and risks; investigating and reporting on injuries and illnesses in the workplace, and minimizing environmental impacts, to comply with the HSE COSHH regulations and Management of Health and Safety at Work Regulations 1999. The role represents the Altos Cambridge Institute on EHS matters to regulatory agencies, inspectors, partners, and project teams, working closely with other line unit functions, consultants, and contractors as required. Responsibilities Working under the leadership of the Sr. Director, Environmental, Health & Safety, this role will manage, engage, monitor, and act on all aspects of Cambridge Institute site activities, and potentially global EH&S activities as assigned, including, but not limited to: - Leading the Cambridge Institute Health and Safety Committee team to influence and support good EH&S behaviors and compliance Represent EHS at the Cambridge Institute Operations Committee to ensure effective collaboration, communication and partnership with key functions. Be a steward for the overall management, including required recordkeeping, of all site EH&S programs including Emergency Planning and Response, Emergency Response Team, Laboratory Safety Programs, Occupational Safety and Industrial Hygiene, DSE (display screen equipment), ergonomic, hazardous materials and waste identification, evaluation, management and reporting, working with the EHS Leadership Team to ensure all program obligations are met. Develop and Implement new programs and training for employees and contractors, including orientation for new hires in coordination with the EH&S Leadership Team, Promoting a culture of safety in all aspects of operations, sponsoring line unit committees, self-inspections, and improvements. Conduct, coordinate and participate in facility EH&S inspections to mitigate hazards, Partner with Facilities to ensure the site regulated waste management program is effective and compliant with HSE regulations, and that the site has appropriate engineering controls to maintain safe work practices in labs, Leading the site planning & coordination of emergency drills and emergency response team preparation activities. Performing job site Risk Assessments (chemical, biologic, equipment, procedural) as needed in facilities and laboratory environments to identify hazards including unsafe conditions, employee exposure, ergonomic, and other compliance concerns, and recognize opportunities for risk mitigation and continuous improvement. Monitor and maintain EH&S records and permits in compliance with all applicable local and country regulations and company requirements, assuring appropriate confidentiality where necessary. Act as Biological Safety Officer/Adviser for the Cambridge Institute. This is an onsite role with no hybrid or remote working. Occasional international travel may be required to participate in global team meetings in the US. Who You Are Minimum Qualifications - Bachelor's of Science degree in physical science or engineering, Advanced degree preferred Minimum of (10) ten years of experience in EHS administration and leadership. Experience with developing and implementing EHS programs for startup laboratory operations preferred Professional certification desirable in IOSH (Institution of Occupational Safety and Health) or NEBOSH (National Examination Board in Occupational Safety and Health) Preferred Qualifications - Thorough knowledge of regulatory requirements relating to HSE, COSHH (Control of Substances Hazardous to Health), International building and fire codes and application to biologic and chemical startup laboratory operations Excels at collaboration, project management, and leading through influence at all levels of an organization effectively contribute to a positive team dynamic and drive results through positive influence The ideal candidate is both a strategic and tactical leader responsible for developing, implementing, and overseeing comprehensive EHS programs collaboratively within the local and global organization as well as someone who is capable of managing and executing on the hands-on work of the day-to-day operations of the team. Ability to work in a high accountability and fast-paced environment, to perform multiple tasks, to make decisions and handle emergency situations typical for a startup operation. Iterate quickly without compromising quality and set the standard on operational excellence. Proven track record of excellent communication skills and practices. The salary range for Cambridge, UK: - Director, Environmental, Health and Safety (EHS): £113,900 - £154,100 Exact compensation may vary based on skills, experience, and location. Before submitting your application: - Please click here to read the Altos Labs EU and UK Applicant Privacy Notice - This Privacy Notice is not a contract, express or implied and it does not set terms or conditions of employment. We are a culture of collaboration and scientific excellence, and we believe in the values of inclusion and belonging to inspire innovation. Altos Labs provides equal employment opportunities to all employees and applicants for employment and prohibits discrimination and harassment of any type without regard to race, color, religion, age, sex, national origin, disability status, genetics, protected veteran status, sexual orientation, gender identity or expression, or any other characteristic protected by federal, state or local laws. This policy applies to all terms and conditions of employment, including recruiting, hiring, placement, promotion, termination, layoff, recall, transfer, leaves of absence, compensation and training. Altos currently requires all employees to be fully vaccinated against COVID-19, subject to legally required exemptions (e.g., due to a medical condition or sincerely-held religious belief). Thank you for your interest in Altos Labs where we strive for a culture of scientific excellence, learning, and belonging.
Sep 29, 2025
Full time
Director, Environmental, Health and Safety (EHS) Our mission is to restore cell health and resilience through cell rejuvenation to reverse disease, injury, and the disabilities that can occur throughout life. For more information, see our website at Our Single Altos Value: Everyone Owns Achieving Our Inspiring Mission. We believe that diverse perspectives are foundational to scientific innovation and inquiry. At Altos, exceptional scientists and industry leaders from around the world work together to advance a shared mission. Our intentional focus is on Belonging, so that all employees know that they are valued for their unique perspectives. We are all accountable for sustaining a diverse and inclusive environment. As a key member of our Global Compliance Team, the Director, EHS, Cambridge Institute (CI), is responsible for developing, implementing, and sustaining EHS improvement programs and policies for the laboratories and support functions at Altos' Cambridge Institute. The programs focus on preventing occupational injuries and illnesses, identifying and mitigating operational hazards and risks; investigating and reporting on injuries and illnesses in the workplace, and minimizing environmental impacts, to comply with the HSE COSHH regulations and Management of Health and Safety at Work Regulations 1999. The role represents the Altos Cambridge Institute on EHS matters to regulatory agencies, inspectors, partners, and project teams, working closely with other line unit functions, consultants, and contractors as required. Responsibilities Working under the leadership of the Sr. Director, Environmental, Health & Safety, this role will manage, engage, monitor, and act on all aspects of Cambridge Institute site activities, and potentially global EH&S activities as assigned, including, but not limited to: - Leading the Cambridge Institute Health and Safety Committee team to influence and support good EH&S behaviors and compliance Represent EHS at the Cambridge Institute Operations Committee to ensure effective collaboration, communication and partnership with key functions. Be a steward for the overall management, including required recordkeeping, of all site EH&S programs including Emergency Planning and Response, Emergency Response Team, Laboratory Safety Programs, Occupational Safety and Industrial Hygiene, DSE (display screen equipment), ergonomic, hazardous materials and waste identification, evaluation, management and reporting, working with the EHS Leadership Team to ensure all program obligations are met. Develop and Implement new programs and training for employees and contractors, including orientation for new hires in coordination with the EH&S Leadership Team, Promoting a culture of safety in all aspects of operations, sponsoring line unit committees, self-inspections, and improvements. Conduct, coordinate and participate in facility EH&S inspections to mitigate hazards, Partner with Facilities to ensure the site regulated waste management program is effective and compliant with HSE regulations, and that the site has appropriate engineering controls to maintain safe work practices in labs, Leading the site planning & coordination of emergency drills and emergency response team preparation activities. Performing job site Risk Assessments (chemical, biologic, equipment, procedural) as needed in facilities and laboratory environments to identify hazards including unsafe conditions, employee exposure, ergonomic, and other compliance concerns, and recognize opportunities for risk mitigation and continuous improvement. Monitor and maintain EH&S records and permits in compliance with all applicable local and country regulations and company requirements, assuring appropriate confidentiality where necessary. Act as Biological Safety Officer/Adviser for the Cambridge Institute. This is an onsite role with no hybrid or remote working. Occasional international travel may be required to participate in global team meetings in the US. Who You Are Minimum Qualifications - Bachelor's of Science degree in physical science or engineering, Advanced degree preferred Minimum of (10) ten years of experience in EHS administration and leadership. Experience with developing and implementing EHS programs for startup laboratory operations preferred Professional certification desirable in IOSH (Institution of Occupational Safety and Health) or NEBOSH (National Examination Board in Occupational Safety and Health) Preferred Qualifications - Thorough knowledge of regulatory requirements relating to HSE, COSHH (Control of Substances Hazardous to Health), International building and fire codes and application to biologic and chemical startup laboratory operations Excels at collaboration, project management, and leading through influence at all levels of an organization effectively contribute to a positive team dynamic and drive results through positive influence The ideal candidate is both a strategic and tactical leader responsible for developing, implementing, and overseeing comprehensive EHS programs collaboratively within the local and global organization as well as someone who is capable of managing and executing on the hands-on work of the day-to-day operations of the team. Ability to work in a high accountability and fast-paced environment, to perform multiple tasks, to make decisions and handle emergency situations typical for a startup operation. Iterate quickly without compromising quality and set the standard on operational excellence. Proven track record of excellent communication skills and practices. The salary range for Cambridge, UK: - Director, Environmental, Health and Safety (EHS): £113,900 - £154,100 Exact compensation may vary based on skills, experience, and location. Before submitting your application: - Please click here to read the Altos Labs EU and UK Applicant Privacy Notice - This Privacy Notice is not a contract, express or implied and it does not set terms or conditions of employment. We are a culture of collaboration and scientific excellence, and we believe in the values of inclusion and belonging to inspire innovation. Altos Labs provides equal employment opportunities to all employees and applicants for employment and prohibits discrimination and harassment of any type without regard to race, color, religion, age, sex, national origin, disability status, genetics, protected veteran status, sexual orientation, gender identity or expression, or any other characteristic protected by federal, state or local laws. This policy applies to all terms and conditions of employment, including recruiting, hiring, placement, promotion, termination, layoff, recall, transfer, leaves of absence, compensation and training. Altos currently requires all employees to be fully vaccinated against COVID-19, subject to legally required exemptions (e.g., due to a medical condition or sincerely-held religious belief). Thank you for your interest in Altos Labs where we strive for a culture of scientific excellence, learning, and belonging.
About us The Francis Crick Institute is Europe's largest biomedical research institute under one roof. Our world-class scientists and staff collaborate on vital research to help prevent, diagnose and treat illnesses such as cancer, heart disease, infectious diseases and neurodegenerative conditions. The Crick is a place for collaboration, innovation and exploration across many disciplines. A space where the brightest minds can pursue big and bold ideas and discover answers to crucial scientific questions. We support them in a dynamic environment which fosters excellence with state-of-the-art infrastructure, cutting-edge facilities, and a creative and curious culture. We've removed traditional boundaries of departments, divisions and disciplines and instead have an open approach that supports every researcher. This gives us the freedom to take risks and carry out high-quality, pioneering research. Creating a space for discovery without boundaries helps us to turn our science into benefits for human health and the economy. About the role To supports its mission, the Crick organises access to high-end equipment and related technical expertise, for all its scientists, through our Science Technology Platforms (STP). There are 18 world-class STPs, ranging from cell services and biological research facilities, to high throughput screening, genomics and bioinformatics. These core facilities are crucial for the success of our research and represent a major ongoing investment by the institute. We are looking recruit an expert with an international reputation to lead and manage our Stem Cell and Organoids Platform. The Lead of the Stem Cell and Organoids Platform will advance the research at the Institute by working in collaboration with renowned Crick scientists, including Charles Swanton, Sonia Gandhi, Maximiliano Gutierrez, Silvia Santos and Foad Rouhani to support all aspects of human stem cell work, organoid technologies, and complex in vitro human models. The Stem Cell and Organoids Platform is currently a team of 7 experienced scientists, with expectation to expand in line with evolving scientific needs. You will lead and manage a team of scientists to deliver effective stem cell-based research support across the institute. The key areas of focus will be on: - Offering access to fully-functional stem cell culture facilities, specialised instrumentation, high quality reagents and protocols, training, and expert advice Providing state-of-the-art services in: i) maintenance, expansion and banking of human stem cells with extensive quality control, ii) reprogramming capabilities to generate iPSCs, iii) directed differentiation into specific cell types for downstream research applications, iv) gene editing in stem cells (eg. hEPSCs and hiPSCs). Developing, establishing, and refining protocols for differentiation of stem cells in both 2D culture conditions and 3D organoid systems. Working in collaboration with Crick research groups and other Scientific Platforms to establish and validate complex in vitro human models of health and disease. You will be responsible for working with Crick Scientist to develop and implement the strategic vision for the future direction of the Stem Cell and Organoids Platform. This includes identifying research priorities and evaluating new techniques and technologies. What you will be doing As a Stem Cell and Organoids Platform Lead at the Crick, some of your key responsibilities will be: - Engaging with Crick Scientists (namely Swanton, Gandhi, Gutierrez, Santos and Rouhani) to establish a long-term strategy for providing world class human models and stem cell capabilities at the Crick. Managing a state-of-the-art platform with cutting edge technologies and protocols. Managing, supervising, and training facility staff, including responsibility for recruitment, onboarding, and professional development. Delivering excellent and timely in vitro human models and stem cell support to scientists within the Crick. Evaluating new approaches, techniques, and instrumentation within the hPSC, organoid, and in vitro models' field, including beta-testing of systems under development, and implementing them in the STP as appropriate to maintain a cutting-edge facility. - Maintaining continuing professional development in relevant scientific areas by attending scientific meetings and conferences. About you You will bring - PhD in a relevant scientific discipline (e.g. cell biology, stem cell biology, developmental biology, molecular biology) or commensurate experience in an academic or industrial setting. Strong track record in stem cell research, documented by published research articles Extensive experience in stem cell culture with evidence of research and development, regulatory compliance, and successful grant applications. Evidence of success and international recognition as a facility leader. Significant hands-on or management experience in several of the following techniques: stem cell culture, stem cell differentiation, gene editing, laboratory automation, and/or human model development. - Significant experience in a management or leadership role in a core facility, including responsibility for line management of multidisciplinary teams. About Working at the Crick Our values Everyone who works at the Crick has a valuable role to play in advancing the Crick's mission and shaping our culture! - We are bold . We make space for creative, dynamic and imaginative ideas and approaches. We're not afraid to do things differently. - We are open . We're highly collaborative and interactive, and make sure our activities are visible to the outside world. - We are collegial . We show respect for one another, work cooperatively and support the wider community. At the Francis Crick Institute, we believe that diversity and inclusion are essential to driving innovation and scientific discovery. We are committed to creating a workplace where everyone feels valued, respected, and empowered to succeed, regardless of their background, identity, or personal circumstances. We actively encourage applications from individuals of all genders, ethnicities, abilities, and experiences. Weare a Disability Confident: Committed employer andwant to ensure that everyone can apply and be part of our recruitment processes and sowe'llmake reasonable adjustments if you need them - just let us know when you apply. If you needassistancewith applying (i.e., would like to apply by phone or post)please email: What will you receive? At the Francis Crick Institute, we value our team members and are proud to offer an extensive range of benefits to support their well-being and development: - Visas: Applicants for this role will be eligible for sponsorship to work in the UK - Generous Leave : 28 days of annual leave, plus three additional days over Christmas and bank holidays. - Pension Scheme : Defined contribution pension with employer contributions of up to 16%. - Health & Well-being : - 24/7 GP consultation services. - Occupational health services and mental health support programs. - Eye care vouchers and discounted healthcare plans. - Work-Life Balance : - Back-up care for dependents. - Childcare support allowance. - Annual leave purchase options. Crick Networks offering diverse groups' support, community and inclusive social events. - Perks : - Discounted gym memberships, bike-to-work scheme, and shopping discounts. - Subsidised on-site restaurant and social spaces for team interaction.
Sep 11, 2025
Full time
About us The Francis Crick Institute is Europe's largest biomedical research institute under one roof. Our world-class scientists and staff collaborate on vital research to help prevent, diagnose and treat illnesses such as cancer, heart disease, infectious diseases and neurodegenerative conditions. The Crick is a place for collaboration, innovation and exploration across many disciplines. A space where the brightest minds can pursue big and bold ideas and discover answers to crucial scientific questions. We support them in a dynamic environment which fosters excellence with state-of-the-art infrastructure, cutting-edge facilities, and a creative and curious culture. We've removed traditional boundaries of departments, divisions and disciplines and instead have an open approach that supports every researcher. This gives us the freedom to take risks and carry out high-quality, pioneering research. Creating a space for discovery without boundaries helps us to turn our science into benefits for human health and the economy. About the role To supports its mission, the Crick organises access to high-end equipment and related technical expertise, for all its scientists, through our Science Technology Platforms (STP). There are 18 world-class STPs, ranging from cell services and biological research facilities, to high throughput screening, genomics and bioinformatics. These core facilities are crucial for the success of our research and represent a major ongoing investment by the institute. We are looking recruit an expert with an international reputation to lead and manage our Stem Cell and Organoids Platform. The Lead of the Stem Cell and Organoids Platform will advance the research at the Institute by working in collaboration with renowned Crick scientists, including Charles Swanton, Sonia Gandhi, Maximiliano Gutierrez, Silvia Santos and Foad Rouhani to support all aspects of human stem cell work, organoid technologies, and complex in vitro human models. The Stem Cell and Organoids Platform is currently a team of 7 experienced scientists, with expectation to expand in line with evolving scientific needs. You will lead and manage a team of scientists to deliver effective stem cell-based research support across the institute. The key areas of focus will be on: - Offering access to fully-functional stem cell culture facilities, specialised instrumentation, high quality reagents and protocols, training, and expert advice Providing state-of-the-art services in: i) maintenance, expansion and banking of human stem cells with extensive quality control, ii) reprogramming capabilities to generate iPSCs, iii) directed differentiation into specific cell types for downstream research applications, iv) gene editing in stem cells (eg. hEPSCs and hiPSCs). Developing, establishing, and refining protocols for differentiation of stem cells in both 2D culture conditions and 3D organoid systems. Working in collaboration with Crick research groups and other Scientific Platforms to establish and validate complex in vitro human models of health and disease. You will be responsible for working with Crick Scientist to develop and implement the strategic vision for the future direction of the Stem Cell and Organoids Platform. This includes identifying research priorities and evaluating new techniques and technologies. What you will be doing As a Stem Cell and Organoids Platform Lead at the Crick, some of your key responsibilities will be: - Engaging with Crick Scientists (namely Swanton, Gandhi, Gutierrez, Santos and Rouhani) to establish a long-term strategy for providing world class human models and stem cell capabilities at the Crick. Managing a state-of-the-art platform with cutting edge technologies and protocols. Managing, supervising, and training facility staff, including responsibility for recruitment, onboarding, and professional development. Delivering excellent and timely in vitro human models and stem cell support to scientists within the Crick. Evaluating new approaches, techniques, and instrumentation within the hPSC, organoid, and in vitro models' field, including beta-testing of systems under development, and implementing them in the STP as appropriate to maintain a cutting-edge facility. - Maintaining continuing professional development in relevant scientific areas by attending scientific meetings and conferences. About you You will bring - PhD in a relevant scientific discipline (e.g. cell biology, stem cell biology, developmental biology, molecular biology) or commensurate experience in an academic or industrial setting. Strong track record in stem cell research, documented by published research articles Extensive experience in stem cell culture with evidence of research and development, regulatory compliance, and successful grant applications. Evidence of success and international recognition as a facility leader. Significant hands-on or management experience in several of the following techniques: stem cell culture, stem cell differentiation, gene editing, laboratory automation, and/or human model development. - Significant experience in a management or leadership role in a core facility, including responsibility for line management of multidisciplinary teams. About Working at the Crick Our values Everyone who works at the Crick has a valuable role to play in advancing the Crick's mission and shaping our culture! - We are bold . We make space for creative, dynamic and imaginative ideas and approaches. We're not afraid to do things differently. - We are open . We're highly collaborative and interactive, and make sure our activities are visible to the outside world. - We are collegial . We show respect for one another, work cooperatively and support the wider community. At the Francis Crick Institute, we believe that diversity and inclusion are essential to driving innovation and scientific discovery. We are committed to creating a workplace where everyone feels valued, respected, and empowered to succeed, regardless of their background, identity, or personal circumstances. We actively encourage applications from individuals of all genders, ethnicities, abilities, and experiences. Weare a Disability Confident: Committed employer andwant to ensure that everyone can apply and be part of our recruitment processes and sowe'llmake reasonable adjustments if you need them - just let us know when you apply. If you needassistancewith applying (i.e., would like to apply by phone or post)please email: What will you receive? At the Francis Crick Institute, we value our team members and are proud to offer an extensive range of benefits to support their well-being and development: - Visas: Applicants for this role will be eligible for sponsorship to work in the UK - Generous Leave : 28 days of annual leave, plus three additional days over Christmas and bank holidays. - Pension Scheme : Defined contribution pension with employer contributions of up to 16%. - Health & Well-being : - 24/7 GP consultation services. - Occupational health services and mental health support programs. - Eye care vouchers and discounted healthcare plans. - Work-Life Balance : - Back-up care for dependents. - Childcare support allowance. - Annual leave purchase options. Crick Networks offering diverse groups' support, community and inclusive social events. - Perks : - Discounted gym memberships, bike-to-work scheme, and shopping discounts. - Subsidised on-site restaurant and social spaces for team interaction.
About us The Francis Crick Institute is Europe's largest biomedical research institute under one roof. Our world-class scientists and staff collaborate on vital research to help prevent, diagnose and treat illnesses such as cancer, heart disease, infectious diseases and neurodegenerative conditions. The Crick is a place for collaboration, innovation and exploration across many disciplines. A space where the brightest minds can pursue big and bold ideas and discover answers to crucial scientific questions. We support them in a dynamic environment which fosters excellence with state-of-the-art infrastructure, cutting-edge facilities, and a creative and curious culture. We've removed traditional boundaries of departments, divisions and disciplines and instead have an open approach that supports every researcher. This gives us the freedom to take risks and carry out high-quality, pioneering research. Creating a space for discovery without boundaries helps us to turn our science into benefits for human health and the economy. About the role The Information Technology Office (ITO) team within the Francis Crick Institute is responsible for the design, implementation and operation of IT services which manage the running of the institute, along with the publication and library services provided to scientists. Within this team, this role will be responsible for the design of new services for a variety of different projects within the Crick, relating to Enterprise Resource Planning, Service Management, Data exploitation, Talent acquisition and management, and more. This is an exciting opportunity to join one of the world's leading research Institutes at a crucial time in its evolution, and play a definitive role in shaping it for the future. As a Senior Solutions Architect, you will be working with business analysts reviewing requirements and translating them into solution designs. You will be working on multiple and different projects and business domains, collaborating with both technical and business stakeholders from across the organisation. If you have a background as a developer and experience developing programming concepts, working with CI/CD pipelines and coding best practices, as well as cloud ecosystems, this may be a great opportunity for you to join the team. What you will be doing As a Senior Solution Architect at the Crick, you will: Translate solution requirements into high level end-to-end solution designs across delivery projects. Create compliant and robust solution architectures aligned with business and legal requirements, as well as policy. Support architectural reviews and tooling decisions. Managing stakeholder relationships - both technical and business. Continual optimisation of services, and elimination of technical debt. Proposals for introduction of new services, or transformation of existing ones, to meet the strategic objectives of the Crick. Support the Development teams to develop, test and operate new enterprise software services. About you You will have: Degree level education, ideally in Computer Science or related STEM subject (or equivalent experience). Experience working on IT/Software projects. Experience in designing End to End solutions. Demonstrable experience in hands-on software development, with previous experience as a developer. Experienced in implementing and working with CI/CD pipelines and best working practices. Up to date knowledge of Coding standards and coding best practices. About Working at the Crick Our values Everyone who works at the Crick has a valuable role to play in advancing the Crick's mission and shaping our culture! We are bold . We make space for creative, dynamic and imaginative ideas and approaches. We're not afraid to do things differently. We are open . We're highly collaborative and interactive, and make sure our activities are visible to the outside world. We are collegial . We show respect for one another, work cooperatively and support the wider community. At the Francis Crick Institute, we believe that diversity and inclusion are essential to driving innovation and scientific discovery. We are committed to creating a workplace where everyone feels valued, respected, and empowered to succeed, regardless of their background, identity, or personal circumstances. We actively encourage applications from individuals of all genders, ethnicities, abilities, and experiences. We are a Disability Confident: Committed employer and want to ensure that everyone can apply and be part of our recruitment processes and so we will make reasonable adjustments if you need them - just let us know when you apply. If you need assistance with applying (i.e., would like to apply by phone or post)please email: What will you receive? At the Francis Crick Institute, we value our team members and are proud to offer an extensive range of benefits to support their well-being and development: Visas: Applicants for this role will be eligible for sponsorship to work in the UK Generous Leave : 28 days of annual leave, plus three additional days over Christmas and bank holidays. Pension Scheme : Defined contribution pension with employer contributions of up to 16%. 24/7 GP consultation services. Occupational health services and mental health support programs. Eye care vouchers and discounted healthcare plans. Work-Life Balance : Childcare support allowance. Annual leave purchase options. Crick Networks offering diverse groups' support, community and inclusive social events. Discounted gym memberships, bike-to-work scheme, and shopping discounts. Subsidised on-site restaurant and social spaces for team interaction.
Sep 11, 2025
Full time
About us The Francis Crick Institute is Europe's largest biomedical research institute under one roof. Our world-class scientists and staff collaborate on vital research to help prevent, diagnose and treat illnesses such as cancer, heart disease, infectious diseases and neurodegenerative conditions. The Crick is a place for collaboration, innovation and exploration across many disciplines. A space where the brightest minds can pursue big and bold ideas and discover answers to crucial scientific questions. We support them in a dynamic environment which fosters excellence with state-of-the-art infrastructure, cutting-edge facilities, and a creative and curious culture. We've removed traditional boundaries of departments, divisions and disciplines and instead have an open approach that supports every researcher. This gives us the freedom to take risks and carry out high-quality, pioneering research. Creating a space for discovery without boundaries helps us to turn our science into benefits for human health and the economy. About the role The Information Technology Office (ITO) team within the Francis Crick Institute is responsible for the design, implementation and operation of IT services which manage the running of the institute, along with the publication and library services provided to scientists. Within this team, this role will be responsible for the design of new services for a variety of different projects within the Crick, relating to Enterprise Resource Planning, Service Management, Data exploitation, Talent acquisition and management, and more. This is an exciting opportunity to join one of the world's leading research Institutes at a crucial time in its evolution, and play a definitive role in shaping it for the future. As a Senior Solutions Architect, you will be working with business analysts reviewing requirements and translating them into solution designs. You will be working on multiple and different projects and business domains, collaborating with both technical and business stakeholders from across the organisation. If you have a background as a developer and experience developing programming concepts, working with CI/CD pipelines and coding best practices, as well as cloud ecosystems, this may be a great opportunity for you to join the team. What you will be doing As a Senior Solution Architect at the Crick, you will: Translate solution requirements into high level end-to-end solution designs across delivery projects. Create compliant and robust solution architectures aligned with business and legal requirements, as well as policy. Support architectural reviews and tooling decisions. Managing stakeholder relationships - both technical and business. Continual optimisation of services, and elimination of technical debt. Proposals for introduction of new services, or transformation of existing ones, to meet the strategic objectives of the Crick. Support the Development teams to develop, test and operate new enterprise software services. About you You will have: Degree level education, ideally in Computer Science or related STEM subject (or equivalent experience). Experience working on IT/Software projects. Experience in designing End to End solutions. Demonstrable experience in hands-on software development, with previous experience as a developer. Experienced in implementing and working with CI/CD pipelines and best working practices. Up to date knowledge of Coding standards and coding best practices. About Working at the Crick Our values Everyone who works at the Crick has a valuable role to play in advancing the Crick's mission and shaping our culture! We are bold . We make space for creative, dynamic and imaginative ideas and approaches. We're not afraid to do things differently. We are open . We're highly collaborative and interactive, and make sure our activities are visible to the outside world. We are collegial . We show respect for one another, work cooperatively and support the wider community. At the Francis Crick Institute, we believe that diversity and inclusion are essential to driving innovation and scientific discovery. We are committed to creating a workplace where everyone feels valued, respected, and empowered to succeed, regardless of their background, identity, or personal circumstances. We actively encourage applications from individuals of all genders, ethnicities, abilities, and experiences. We are a Disability Confident: Committed employer and want to ensure that everyone can apply and be part of our recruitment processes and so we will make reasonable adjustments if you need them - just let us know when you apply. If you need assistance with applying (i.e., would like to apply by phone or post)please email: What will you receive? At the Francis Crick Institute, we value our team members and are proud to offer an extensive range of benefits to support their well-being and development: Visas: Applicants for this role will be eligible for sponsorship to work in the UK Generous Leave : 28 days of annual leave, plus three additional days over Christmas and bank holidays. Pension Scheme : Defined contribution pension with employer contributions of up to 16%. 24/7 GP consultation services. Occupational health services and mental health support programs. Eye care vouchers and discounted healthcare plans. Work-Life Balance : Childcare support allowance. Annual leave purchase options. Crick Networks offering diverse groups' support, community and inclusive social events. Discounted gym memberships, bike-to-work scheme, and shopping discounts. Subsidised on-site restaurant and social spaces for team interaction.
Details of the role: This is a full-time, fixed-term (two years) position on Crick terms and conditions of employment. About us The Francis Crick Institute is Europe's largest biomedical research institute under one roof. Our world-class scientists and staff collaborate on vital research to help prevent, diagnose, and treat illnesses such as cancer, heart disease, infectious diseases, and neurodegenerative conditions. The Crick is a place for collaboration, innovation, and exploration across many disciplines. It is a space where the brightest minds pursue big ideas and discover answers to crucial scientific questions. We support a dynamic environment with state-of-the-art infrastructure, cutting-edge facilities, and a creative, curious culture. We have an open approach that removes traditional boundaries between departments, divisions, and disciplines, fostering high-quality, pioneering research. Our goal is to translate scientific discoveries into benefits for human health and the economy. About the role We are seeking an experienced Postdoctoral Project Research Scientist to join our team. You will lead your own independent projects and contribute to developing innovative tools and technologies that advance our research. You will work in a collaborative and diverse group dedicated to understanding how a functional, beating heart forms during development. Your work will involve applying expertise in cutting-edge imaging technologies, image analysis, and biophysical approaches. The specific projects will be tailored to your background and interests in close consultation with your supervisor. The heart is the first organ to form and function during embryonic development. A key process is chamber maturation, where the myocardial wall transforms from a single-layered epithelium into a complex 3D architecture. Our lab aims to uncover the mechanical, molecular, and geometric interactions that drive this transformation, using zebrafish models, quantitative imaging, transcriptomics, biophysics, genetics, and theoretical modeling. What you will be doing: As a PPRS you will: Develop and establish new tools and techniques, including advanced 4D live imaging of zebrafish hearts, image analysis pipelines, biophysical force measurement methods, and gene-editing tools. Conceptualize and lead research projects. Provide expert guidance and technical support to lab members, fostering knowledge exchange and skill development. Contribute to other projects collaboratively within the lab and with external partners. Actively contribute to scientific publications. Help cultivate a collaborative, inclusive, and stimulating lab environment. About you You will bring: PhD (or near completion) in cell biology, developmental biology, or biophysics. Proven expertise in advanced confocal and light-sheet microscopy, demonstrated by publications. Excellent molecular biology skills. Experience in embryological techniques (zebrafish, fly, mouse) and gene editing methods. Ability to write scientific papers, as evidenced by publications and/or preprints in relevant fields.
Sep 11, 2025
Full time
Details of the role: This is a full-time, fixed-term (two years) position on Crick terms and conditions of employment. About us The Francis Crick Institute is Europe's largest biomedical research institute under one roof. Our world-class scientists and staff collaborate on vital research to help prevent, diagnose, and treat illnesses such as cancer, heart disease, infectious diseases, and neurodegenerative conditions. The Crick is a place for collaboration, innovation, and exploration across many disciplines. It is a space where the brightest minds pursue big ideas and discover answers to crucial scientific questions. We support a dynamic environment with state-of-the-art infrastructure, cutting-edge facilities, and a creative, curious culture. We have an open approach that removes traditional boundaries between departments, divisions, and disciplines, fostering high-quality, pioneering research. Our goal is to translate scientific discoveries into benefits for human health and the economy. About the role We are seeking an experienced Postdoctoral Project Research Scientist to join our team. You will lead your own independent projects and contribute to developing innovative tools and technologies that advance our research. You will work in a collaborative and diverse group dedicated to understanding how a functional, beating heart forms during development. Your work will involve applying expertise in cutting-edge imaging technologies, image analysis, and biophysical approaches. The specific projects will be tailored to your background and interests in close consultation with your supervisor. The heart is the first organ to form and function during embryonic development. A key process is chamber maturation, where the myocardial wall transforms from a single-layered epithelium into a complex 3D architecture. Our lab aims to uncover the mechanical, molecular, and geometric interactions that drive this transformation, using zebrafish models, quantitative imaging, transcriptomics, biophysics, genetics, and theoretical modeling. What you will be doing: As a PPRS you will: Develop and establish new tools and techniques, including advanced 4D live imaging of zebrafish hearts, image analysis pipelines, biophysical force measurement methods, and gene-editing tools. Conceptualize and lead research projects. Provide expert guidance and technical support to lab members, fostering knowledge exchange and skill development. Contribute to other projects collaboratively within the lab and with external partners. Actively contribute to scientific publications. Help cultivate a collaborative, inclusive, and stimulating lab environment. About you You will bring: PhD (or near completion) in cell biology, developmental biology, or biophysics. Proven expertise in advanced confocal and light-sheet microscopy, demonstrated by publications. Excellent molecular biology skills. Experience in embryological techniques (zebrafish, fly, mouse) and gene editing methods. Ability to write scientific papers, as evidenced by publications and/or preprints in relevant fields.