GSK (R&D)

Salary: EUR Monthly Hours:36.00 - 40.00 We create a place where people can grow, be their best, be safe, and feel welcome, valued and included. We offer a competitive salary, an annual bonus based on company performance, healthcare and wellbeing programmes, pension plan membership, and shares and savings programme. Discover more about our company wide benefits and life at GSK on our webpage Life at GSK GSK Senior Scientist Enzyme and Oligonucleotide Development (EOD) UK We are seeking a motivated Oligonucleotide chemist to join the Enzyme and Oligonucleotide Development (EOD) department at GSK's flagship R&D site at Stevenage in Hertfordshire. As a Senior Scientist in EOD UK you will use your process chemistry knowledge and expertise to optimise routes for manufacture of oligonucleotide active pharmaceutical ingredients (APIs) and contribute to the development and deployment of state-of-the-art processes and technologies enabling the delivery of our medicines. Potentially, you will lead significant parts of chemistry development programs, directing the work of other scientists globally in a matrix team. As projects advance through development there may be opportunities to lead pilot plant supplies across scales, culminating in the transfer of projects to commercial manufacturing facilities around the globe. The role is highly technical and dynamic as you will be working in several multi-disciplinary project teams. You will thrive in this environment if you are able to effectively manage multiple priorities, communicate your recommendations clearly, and enjoy working in teams. Based at our R&D hub at Stevenage, the concentration of a large number of scientists inspires a culture of inclusion, equity and diversity with a common goal of innovation and collaboration. The location also benefits from excellent facilities on site and in the surrounding area as well as fast train access to central London and Cambridge. This role is on-site laboratory based but there may be some flexibility for remote working when work permits with manager approval. In this role you will: Design and implement chemical routes and processes to oligonucleotide APIs suitable for scale up, with a focus on process understanding and the acquisition of the right data to support global regulatory filings Optimise chemical manufacturing processes complying with safety, quality, speed, cost, sustainability, reproducibility, and regulatory requirements in all aspects of work Have oversight of API manufacture on g to multi-ton scale to support clinical, regulatory, and commercial launch activities; potentially run internal facilities to support early tox API supply Work to cGMP standards as appropriate Participate in technology transfer activities to transfer new manufacturing processes to our commercial manufacturing partners as appropriate Generate comprehensive conclusion reports, author or contribute to regulatory submissions, patents, scientific papers, and other internal and external documentation relevant to the role Collaborate closely with scientists including analytical colleagues to contribute to accelerated development of new medicines Potentially lead projects within a CMC environment Why you? Basic Qualifications/Essentials: We are looking for professionals with these required skills to achieve our goals: PhD or equivalent academic or industrial laboratory-based experience in Oligonucleotide Chemistry Proven track record of laboratory-scale chemistry execution and creative problem-solving skills, with the ability to identify and resolve potential issues effectively in a multi-functional team Preferred Qualifications & Skills: We are looking for professionals with these preferred skills to achieve our goals: Extensive knowledge of oligonucleotide chemistry including potential routes of impurity formation Practical experience of laboratory scale oligonucleotide synthesis, purification and isolation using Cytiva equipment and Unicorn software Familiarity with techniques for development and understanding of scalable chemical processes e.g., kinetics, statistical design of experiments. Experience working with exploratory data analysis techniques in a programming environment, ideally involving analysis of oligonucleotide synthesis/purification data. Familiarity with control strategy requirements, e.g., analytical specifications, impurity purging and fate mapping, genotoxic impurity risk assessment Ability to effectively communicate in a multi-disciplinary working environment, ensuring every department is informed throughout the scientific division Closing Date for Applications: Sunday 23rd March 2025. To apply, please visit our website via the button below. Please take a copy of the Job Description, as this will not be available post closure of the advert. When applying for this role, please use the 'cover letter' of the online application or your CV to describe how you meet the competencies for this role, as outlined in the job requirements. The information that you have provided in your cover letter and CV will be used to assess your application. GSK R&D At GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people over the next 10 years. R&D is committed to discovering and delivering transformational vaccines and medicines to prevent and change the course of disease. Science and technology are coming together in a way they never have before, and we have strong tech-enabled capabilities that allow us to build a deeper understanding of the patient, human biology and disease mechanisms, and transform medical discovery. We are revolutionising the way we do R&D. We're uniting science, technology and talent to get ahead of disease together. Find out more: Our approach to R&D Why GSK? Uniting science, technology and talent to get ahead of disease together. GSK is a global biopharma company with a special purpose - to unite science, technology and talent to get ahead of disease together - so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns - as an organisation where people can thrive. We prevent and treat disease with vaccines, specialty and general medicines. We focus on the science of the immune system and the use of new platform and data technologies, investing in four core therapeutic areas (infectious diseases, HIV, respiratory/ immunology and oncology). As an Equal Opportunity Employer, we are open to all talent. In the US, we also adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to neurodiversity, race/ethnicity, colour, national origin, religion, gender, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class ( US only). We believe in an agile working culture for all our roles. If flexibility is important to you, we encourage you to explore with our hiring team what the opportunities are. Should you require any adjustments to our process to assist you in demonstrating your strengths and capabilities contact us on or . The helpline is available from 8.30am to 12.00 noon Monday to Friday, during bank holidays these times and days may vary. Please note should your enquiry not relate to adjustments, we will not be able to support you through these channels. However, we have created a UK Recruitment FAQ guide. Click the link and scroll to the Careers Section where you will find answers to multiple questions we receive. As you apply, we will ask you to share some personal information which is entirely voluntary. We want to have an opportunity to consider a diverse pool of qualified candidates and this information will assist us in meeting that objective and in understanding how well we are doing against our inclusion and diversity ambitions. We would really appreciate it if you could take a few moments to complete it. Rest assured, Hiring Managers do not have access to this information and we will treat your information confidentially. Important notice to Employment businesses / Agencies GSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK's commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site. Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license . click apply for full job details