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Organisation/Company Quadram Institute Bioscience Department Biochemistry and Metabolism Research Field Biological sciences " Biology Researcher Profile First Stage Researcher (R1) Positions PhD Positions Application Deadline 22 Mar 2026 - 23:59 (Europe/London) Country United Kingdom Type of Contract Temporary Job Status Full-time Hours Per Week 37 Is the job funded through the EU Research Framework Programme? Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure? No Offer Description Research Scientist We're looking for a motivated Research Scientist to join the laboratory of Dr Lizbeth Sayavedra in the Food, Microbiome and Health programme at Quadram Institute Bioscience. The postholder will help investigate how microbial sulfur and nitrogen metabolism influences human health, with a particular focus on protein malnutrition and obesity. Research in the lab centres on sulphate- and sulphite-reducing bacteria of the Desulfovibrionaceae and their interactions with the host and the wider gut microbiome. Our work uses a range of advanced host-relevant experimental systems, including in vitro and in vivo models, integrated with anaerobic microbiology and metagenomics. This position is ideally suited to a scientist with experience in host-based experimental systems who is motivated to apply microbiome and microbial metabolism approaches to mechanistic questions in host health. The host group and institute are committed to development of staff, and this role offers an exceptional environment for candidates to progress their careers. The role: The post holder will take a leading role in host-focused experimentation, with responsibilities including: Designing and performing tissue culture, organoid, or in vivo experiments to investigate host-microbiome interactions Coordinating microbial perturbation experiments linked to dietary or metabolic interventions Anaerobic culturing and preparation of gut bacteria, particularly members of the Desulfovibrionaceae, for host interaction studies Application of genetic and functional genomics approaches to investigate sulfur and nitrogen metabolic pathways Integration of host experimental data with metagenomic analyses, including interpretation of microbial functional potential and activity Contribution to study design, data integration, publications, presentations, and future grant proposals The ideal candidate: Candidates should hold a PhD in microbiology, molecular microbiology or a related discipline. The postholder will have demonstrable hands on experience with tissue culture, organoids, and/or in vivo models as well as a solid understanding of host-microbiome interactions and experimental design in host systems. Candidates should have a working knowledge of metagenomics and bioinformatics sufficient to analyse or interpret complex datasets and the ability to work independently and integrate results across host and microbial systems. Experience working with anaerobic bacteria or complex microbial communities and familiarity with Linux based environments or reproducible data analysis workflows would be advantageous. Additional information: Salary on appointment will be within the range £37,500 to £45,350 per annum depending on qualifications and experience. This is a full time for a contract of 36 months with the possibility for extension. This role meets the criteria for a visa application, and we encourage all qualified candidates to apply. Please contact the Human Resources Team if you have any questions regarding your application or visa options. Interviews will be held in late March / early April 2026. We are committed to equity, diversity and inclusion, and welcome applications from all sectors of society. The Institute values of Respect, Innovation, Collaboration and Excellence are at the heart of all we do, and we expect all employees to share and display these values. To support our commitment, we have a range of family, faith and diversity friendly working arrangements to help all staff achieve excellence in their area of work. As a Disability Confident employer, we guarantee to offer an interview to all disabled applicants who meet the essential criteria for this vacancy. About the Quadram Institute: The Quadram Institute is a new interdisciplinary research institute dedicated to understanding how food and microbes interact to promote health and prevent disease. Its mission is to deliver healthier lives through innovation in gut health, microbiology and food. A partnership between Quadram Institute Bioscience, the University of East Anglia, the Norfolk and Norwich University Hospital and BBSRC, it brings together scientists and clinicians in a state of the art building on the Norwich Research Park. This is one of Europe's largest centres of life sciences and home of the John Innes Centre and The Earlham Institute. ( ). The closing date for applications will be 22 March 2026 The Quadram Institute Bioscience is a registered charity (No. ) and is an Equal Opportunities Employer.
Organisation/Company Quadram Institute Bioscience Department Biochemistry and Metabolism Research Field Biological sciences " Biology Researcher Profile First Stage Researcher (R1) Positions PhD Positions Application Deadline 22 Mar 2026 - 23:59 (Europe/London) Country United Kingdom Type of Contract Temporary Job Status Full-time Hours Per Week 37 Is the job funded through the EU Research Framework Programme? Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure? No Offer Description Research Scientist We're looking for a motivated Research Scientist to join the laboratory of Dr Lizbeth Sayavedra in the Food, Microbiome and Health programme at Quadram Institute Bioscience. The postholder will help investigate how microbial sulfur and nitrogen metabolism influences human health, with a particular focus on protein malnutrition and obesity. Research in the lab centres on sulphate- and sulphite-reducing bacteria of the Desulfovibrionaceae and their interactions with the host and the wider gut microbiome. Our work uses a range of advanced host-relevant experimental systems, including in vitro and in vivo models, integrated with anaerobic microbiology and metagenomics. This position is ideally suited to a scientist with experience in host-based experimental systems who is motivated to apply microbiome and microbial metabolism approaches to mechanistic questions in host health. The host group and institute are committed to development of staff, and this role offers an exceptional environment for candidates to progress their careers. The role: The post holder will take a leading role in host-focused experimentation, with responsibilities including: Designing and performing tissue culture, organoid, or in vivo experiments to investigate host-microbiome interactions Coordinating microbial perturbation experiments linked to dietary or metabolic interventions Anaerobic culturing and preparation of gut bacteria, particularly members of the Desulfovibrionaceae, for host interaction studies Application of genetic and functional genomics approaches to investigate sulfur and nitrogen metabolic pathways Integration of host experimental data with metagenomic analyses, including interpretation of microbial functional potential and activity Contribution to study design, data integration, publications, presentations, and future grant proposals The ideal candidate: Candidates should hold a PhD in microbiology, molecular microbiology or a related discipline. The postholder will have demonstrable hands on experience with tissue culture, organoids, and/or in vivo models as well as a solid understanding of host-microbiome interactions and experimental design in host systems. Candidates should have a working knowledge of metagenomics and bioinformatics sufficient to analyse or interpret complex datasets and the ability to work independently and integrate results across host and microbial systems. Experience working with anaerobic bacteria or complex microbial communities and familiarity with Linux based environments or reproducible data analysis workflows would be advantageous. Additional information: Salary on appointment will be within the range £37,500 to £45,350 per annum depending on qualifications and experience. This is a full time for a contract of 36 months with the possibility for extension. This role meets the criteria for a visa application, and we encourage all qualified candidates to apply. Please contact the Human Resources Team if you have any questions regarding your application or visa options. Interviews will be held in late March / early April 2026. We are committed to equity, diversity and inclusion, and welcome applications from all sectors of society. The Institute values of Respect, Innovation, Collaboration and Excellence are at the heart of all we do, and we expect all employees to share and display these values. To support our commitment, we have a range of family, faith and diversity friendly working arrangements to help all staff achieve excellence in their area of work. As a Disability Confident employer, we guarantee to offer an interview to all disabled applicants who meet the essential criteria for this vacancy. About the Quadram Institute: The Quadram Institute is a new interdisciplinary research institute dedicated to understanding how food and microbes interact to promote health and prevent disease. Its mission is to deliver healthier lives through innovation in gut health, microbiology and food. A partnership between Quadram Institute Bioscience, the University of East Anglia, the Norfolk and Norwich University Hospital and BBSRC, it brings together scientists and clinicians in a state of the art building on the Norwich Research Park. This is one of Europe's largest centres of life sciences and home of the John Innes Centre and The Earlham Institute. ( ). The closing date for applications will be 22 March 2026 The Quadram Institute Bioscience is a registered charity (No. ) and is an Equal Opportunities Employer.
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MRC Laboratory Of Molecular Biology, UKRI Postdoctoral Scientist Salary £42,694 per annum Fixed term, 3 years MRC Laboratory of Molecular Biology, Cambridge, UK Job Overview The position is for a Postdoctoral Scientist with expertise on cryoEM and/or protein biochemistry. You will be responsible for expressing, purifying phosphatases and kinases and solving their structures using a combination of approaches, primarily cryoEM and/or crystallography, with the support of LMB facilities. You may also develop new inhibitors and conduct functional studies. Dr Anne Bertolotti's pioneering research programme focuses on innovative approaches to boost stress signaling pathways to increase cellular resilience and protect from diverse diseases including neurodegenerative diseases. We have developed approaches to inhibit or activate phosphatases or kinases of the integrated stress response and are progressing towards a structural understanding of these important enzymes (Tsaytler et al., 2011, Science, 332, 91-4; Das et al., 2015, Science, 348, 239-242; Carrara, M., Sigurdardottir, A., & Bertolotti, A. 2017, Nat Struct Mol Biol; Krzyzosiak, A., Sigurdardottir, A. et al., A. 2018, Cell; Szaruga M, et al., Nat Commun, 2023. 8;14(1):5535; Fatalska A., Hodgson G, et al., Mol Cell. 2024; Miguel, C. D. et al. Science eadw). The small molecules discovered by the group are currently tested in clinical trials for neurodegenerative diseases. You will provide fundamental structural and mechanistic insights on these important enzymes and expand on the next generation of inhibitors. You will join a strong inter-disciplinary team at the LMB, which has broad expertise extending from biochemistry, structural, chemical, molecular and cell biology through to transgenic animal models of degenerative diseases. The team also has an excellent record of innovative basic research leading to applications in medicine. Responsibilities Express, purify phosphatases and kinases and solve their structures using cryoEM and/or crystallography. Develop new inhibitors and conduct functional studies. Provide structural and mechanistic insights on target enzymes and expand on next-generation inhibitors. Qualifications PhD in biochemistry or structural biology, or completing the degree within six months of applying. Relevant experience with at least one impactful and original publication. Interest in signaling enzymes desirable. Ambitious, creative and fearless with a commitment to explore the unknown. Benefits The LMB provides on-site parking, cycle enclosures, and excellent public transport links. There is a staff restaurant with roof terrace and access to a campus nursery and sports and social facilities. Employees are eligible to join a defined benefit pension scheme, receive 40.5 days of holiday per annum (including bank holidays and privilege days), and benefit from a generous employee discount scheme. Training and development opportunities, including support towards role-related qualifications, are available. For more information, see Benefits of working at UKRI . The LMB is a world class research institute within UK Research and Innovation (UKRI). More information can be found at UKRI and MRC LMB . This role qualifies for endorsement by UKRI for a UK Global Talent Visa. Immigration costs (visa and health surcharge) can be reclaimed from UKRI after taking up the post (terms and conditions apply). Closing date: 22 March 2026 Final appointments will be subject to a pre employment screening. Equality and Diversity We actively support equality, diversity and inclusion in all our activities, processes and culture. We encourage applications from all sections of society. The LMB particularly welcomes women, minority ethnic and disabled candidates to apply for this vacancy as they are currently under represented. We are a disability inclusive employer and encourage disabled people to apply. For information about the application process and any adjustments you may require, contact emailprotected .
MRC Laboratory Of Molecular Biology, UKRI Postdoctoral Scientist Salary £42,694 per annum Fixed term, 3 years MRC Laboratory of Molecular Biology, Cambridge, UK Job Overview The position is for a Postdoctoral Scientist with expertise on cryoEM and/or protein biochemistry. You will be responsible for expressing, purifying phosphatases and kinases and solving their structures using a combination of approaches, primarily cryoEM and/or crystallography, with the support of LMB facilities. You may also develop new inhibitors and conduct functional studies. Dr Anne Bertolotti's pioneering research programme focuses on innovative approaches to boost stress signaling pathways to increase cellular resilience and protect from diverse diseases including neurodegenerative diseases. We have developed approaches to inhibit or activate phosphatases or kinases of the integrated stress response and are progressing towards a structural understanding of these important enzymes (Tsaytler et al., 2011, Science, 332, 91-4; Das et al., 2015, Science, 348, 239-242; Carrara, M., Sigurdardottir, A., & Bertolotti, A. 2017, Nat Struct Mol Biol; Krzyzosiak, A., Sigurdardottir, A. et al., A. 2018, Cell; Szaruga M, et al., Nat Commun, 2023. 8;14(1):5535; Fatalska A., Hodgson G, et al., Mol Cell. 2024; Miguel, C. D. et al. Science eadw). The small molecules discovered by the group are currently tested in clinical trials for neurodegenerative diseases. You will provide fundamental structural and mechanistic insights on these important enzymes and expand on the next generation of inhibitors. You will join a strong inter-disciplinary team at the LMB, which has broad expertise extending from biochemistry, structural, chemical, molecular and cell biology through to transgenic animal models of degenerative diseases. The team also has an excellent record of innovative basic research leading to applications in medicine. Responsibilities Express, purify phosphatases and kinases and solve their structures using cryoEM and/or crystallography. Develop new inhibitors and conduct functional studies. Provide structural and mechanistic insights on target enzymes and expand on next-generation inhibitors. Qualifications PhD in biochemistry or structural biology, or completing the degree within six months of applying. Relevant experience with at least one impactful and original publication. Interest in signaling enzymes desirable. Ambitious, creative and fearless with a commitment to explore the unknown. Benefits The LMB provides on-site parking, cycle enclosures, and excellent public transport links. There is a staff restaurant with roof terrace and access to a campus nursery and sports and social facilities. Employees are eligible to join a defined benefit pension scheme, receive 40.5 days of holiday per annum (including bank holidays and privilege days), and benefit from a generous employee discount scheme. Training and development opportunities, including support towards role-related qualifications, are available. For more information, see Benefits of working at UKRI . The LMB is a world class research institute within UK Research and Innovation (UKRI). More information can be found at UKRI and MRC LMB . This role qualifies for endorsement by UKRI for a UK Global Talent Visa. Immigration costs (visa and health surcharge) can be reclaimed from UKRI after taking up the post (terms and conditions apply). Closing date: 22 March 2026 Final appointments will be subject to a pre employment screening. Equality and Diversity We actively support equality, diversity and inclusion in all our activities, processes and culture. We encourage applications from all sections of society. The LMB particularly welcomes women, minority ethnic and disabled candidates to apply for this vacancy as they are currently under represented. We are a disability inclusive employer and encourage disabled people to apply. For information about the application process and any adjustments you may require, contact emailprotected .