Francis Crick Institute Ltd
Postdoctoral Project Research Scientist - C Swanton Cancer Evolution and Genome Instability Laboratory page is loaded Postdoctoral Project Research Scientist - C Swanton Cancer Evolution and Genome Instability Laboratory Apply locations London time type Full time posted on Posted Yesterday job requisition id R2341 Salary for this Role: From £45,500 with benefits, subject to skills and experience. Job Title: Postdoctoral Project Research Scientist - C Swanton Cancer Evolution and Genome Instability Laboratory Reports to: Charles Swanton C Closing Date: 11/Aug/.59 GMT Job Description: Postdoctoral Project Research Scientist - C Swanton Cancer Evolution and Genome Instability Laboratory Reporting to: Charles Swanton, Principal Investigator, Deputy Clinical Director Contact term: This is a full-time 2 year position on Crick terms and conditions of employment. About us The Francis Crick Institute is Europe's largest biomedical research institute under one roof. Our world-class scientists and staff collaborate on vital research to help prevent, diagnose and treat illnesses such as cancer, heart disease, infectious diseases and neurodegenerative conditions. The Crick is a place for collaboration, innovation and exploration across many disciplines. A space where the brightest minds can pursue big and bold ideas and discover answers to crucial scientific questions. We support them in a dynamic environment which fosters excellence with state-of-the-art infrastructure, cutting-edge facilities, and a creative and curious culture. We've removed traditional boundaries of departments, divisions and disciplines and instead have an open approach that supports every researcher. This gives us the freedom to take risks and carry out high-quality, pioneering research. Creating a space for discovery without boundaries helps us to turn our science into benefits for human health and the economy. About the role Our research direction investigates the role of cell lineage upon lung cancer initiation, both in homeostasis and in the context of challenge with non-mutagenic carcinogens. Our research is committed to advancing our understanding the biology of lung tumour evolution based around analysis of next generation sequence (NGS) data and the tumour microenvironment from the TRACERx longitudinal lung cancer program. Leveraging genomic, transcriptomic and epigenomic sequencing as well as spatial immunophenotyping data from patient samples, our aim is to trace the intricate evolutionary trajectories of lung tumours across space and time. This work will unveil the key drivers of cancer progression, immune resistance mechanisms, and potential vulnerabilities within the tumour landscape. As a Postdoctoral Project Research Scientist in the Swanton lab, your main responsibilities will be to work with the informatics team on TRACERx project, whilst also contributing to other projects throughout the lab. If you have experience in Bioinformatics, are fluent in R or Python as well as experience in evolutionary or cancer biology, we would love to hear from you. Please see the full job description here. See more about the lab here. What you will be doing As a Postdoctoral Project Research Scientist at the Crick, some of your main responsibilities will be: To decipher evolutionary mechanisms during lung cancer initiation and progression. To employ novel informatics techniques based on evolutionary principles to the analysis of tumour subclonal evolution. To understand cancer biology and the relevant literature sufficiently to take own ideas forward as lead author on new projects. To work within the informatics team of the TRACERx and TRACERx EVO programs. To record all experiments and code in an accurate timely, clearly presented and reproducable manner, and use this to prepare data summaries and reports as and when required. To attend, and report research results at regular group and external meetings. To contribute to the dissemination of scientific results by means of writing papers for publication, and presenting orally and in poster form at national and international meetings. About you You will have: PhD Previous experience with cancer genomics NGS data Fluent in R or Python Evidence of significant contribution to high impact publications Experience with HPC environments Experience of collaboration with clinicians and wet lab scientists or work within a multi-disciplinary environment About Working at the Crick Our values Everyone who works at the Crick has a valuable role to play in advancing the Crick's mission and shaping our culture! We arebold. We make space for creative, dynamic and imaginative ideas and approaches. We're not afraid to do things differently. We areopen. We're highly collaborative and interactive, and make sure our activities are visible to the outside world. We arecollegial. We show respect for one another, work cooperatively and support the wider community. At the Francis Crick Institute, we believe that diversity and inclusion are essential to driving innovation and scientific discovery. We are committed to creating a workplace where everyone feels valued, respected, and empowered to succeed, regardless of their background, identity, or personal circumstances. We actively encourage applications from individuals of all genders, ethnicities, abilities, and experiences. Weare aDisability Confident: Committedemployer andwant to ensure that everyone can apply and be part of our recruitment processes and sowe'llmake reasonable adjustments if you need them - just let us know when you apply. If you needassistancewith applying (i.e., would like to apply by phone or post) please email: Find out more about life at the Crick. What will you receive? At the Francis Crick Institute, we value our team members and are proud to offer an extensive range of benefits to support their well-being and development: Visas: Applicants for this role will be eligible for sponsorship to work in the UK Generous Leave: 28 days of annual leave, plus three additional days over Christmas and bank holidays. Pension Scheme: Defined contribution pension with employer contributions of up to 16%. Health & Well-being: 24/7 GP consultation services. Occupational health services and mental health support programs. Eye care vouchers and discounted healthcare plans. Work-Life Balance: Back-up care for dependents. Childcare support allowance. Annual leave purchase options. Crick Networks offering diverse groups' support, community and inclusive social events. Perks: Discounted gym memberships, bike-to-work scheme, and shopping discounts. Subsidised on-site restaurant and social spaces for team interaction. Please note you must meet the essential criteria listed within the Role Profile, to have your application reviewed. We reserve the right to withdraw this advert at any given time due to the number of applications received. About Us The Francis Crick Institute is a biomedical discovery institute researching the biology underlying human health. At the Crick, scientists and staff collaborate to stretch the very limits of what we know about how life works. Our work is helping to understand why disease develops and to translate discoveries into new ways to prevent, diagnose and treat illnesses such as cancer, heart disease, stroke, infections and neurodegenerative diseases. The Francis Crick Institute is a charity, founded by the Medical Research Council, Cancer Research UK, Wellcome, UCL (University College London), Imperial College London and King's College London.
Postdoctoral Project Research Scientist - C Swanton Cancer Evolution and Genome Instability Laboratory page is loaded Postdoctoral Project Research Scientist - C Swanton Cancer Evolution and Genome Instability Laboratory Apply locations London time type Full time posted on Posted Yesterday job requisition id R2341 Salary for this Role: From £45,500 with benefits, subject to skills and experience. Job Title: Postdoctoral Project Research Scientist - C Swanton Cancer Evolution and Genome Instability Laboratory Reports to: Charles Swanton C Closing Date: 11/Aug/.59 GMT Job Description: Postdoctoral Project Research Scientist - C Swanton Cancer Evolution and Genome Instability Laboratory Reporting to: Charles Swanton, Principal Investigator, Deputy Clinical Director Contact term: This is a full-time 2 year position on Crick terms and conditions of employment. About us The Francis Crick Institute is Europe's largest biomedical research institute under one roof. Our world-class scientists and staff collaborate on vital research to help prevent, diagnose and treat illnesses such as cancer, heart disease, infectious diseases and neurodegenerative conditions. The Crick is a place for collaboration, innovation and exploration across many disciplines. A space where the brightest minds can pursue big and bold ideas and discover answers to crucial scientific questions. We support them in a dynamic environment which fosters excellence with state-of-the-art infrastructure, cutting-edge facilities, and a creative and curious culture. We've removed traditional boundaries of departments, divisions and disciplines and instead have an open approach that supports every researcher. This gives us the freedom to take risks and carry out high-quality, pioneering research. Creating a space for discovery without boundaries helps us to turn our science into benefits for human health and the economy. About the role Our research direction investigates the role of cell lineage upon lung cancer initiation, both in homeostasis and in the context of challenge with non-mutagenic carcinogens. Our research is committed to advancing our understanding the biology of lung tumour evolution based around analysis of next generation sequence (NGS) data and the tumour microenvironment from the TRACERx longitudinal lung cancer program. Leveraging genomic, transcriptomic and epigenomic sequencing as well as spatial immunophenotyping data from patient samples, our aim is to trace the intricate evolutionary trajectories of lung tumours across space and time. This work will unveil the key drivers of cancer progression, immune resistance mechanisms, and potential vulnerabilities within the tumour landscape. As a Postdoctoral Project Research Scientist in the Swanton lab, your main responsibilities will be to work with the informatics team on TRACERx project, whilst also contributing to other projects throughout the lab. If you have experience in Bioinformatics, are fluent in R or Python as well as experience in evolutionary or cancer biology, we would love to hear from you. Please see the full job description here. See more about the lab here. What you will be doing As a Postdoctoral Project Research Scientist at the Crick, some of your main responsibilities will be: To decipher evolutionary mechanisms during lung cancer initiation and progression. To employ novel informatics techniques based on evolutionary principles to the analysis of tumour subclonal evolution. To understand cancer biology and the relevant literature sufficiently to take own ideas forward as lead author on new projects. To work within the informatics team of the TRACERx and TRACERx EVO programs. To record all experiments and code in an accurate timely, clearly presented and reproducable manner, and use this to prepare data summaries and reports as and when required. To attend, and report research results at regular group and external meetings. To contribute to the dissemination of scientific results by means of writing papers for publication, and presenting orally and in poster form at national and international meetings. About you You will have: PhD Previous experience with cancer genomics NGS data Fluent in R or Python Evidence of significant contribution to high impact publications Experience with HPC environments Experience of collaboration with clinicians and wet lab scientists or work within a multi-disciplinary environment About Working at the Crick Our values Everyone who works at the Crick has a valuable role to play in advancing the Crick's mission and shaping our culture! We arebold. We make space for creative, dynamic and imaginative ideas and approaches. We're not afraid to do things differently. We areopen. We're highly collaborative and interactive, and make sure our activities are visible to the outside world. We arecollegial. We show respect for one another, work cooperatively and support the wider community. At the Francis Crick Institute, we believe that diversity and inclusion are essential to driving innovation and scientific discovery. We are committed to creating a workplace where everyone feels valued, respected, and empowered to succeed, regardless of their background, identity, or personal circumstances. We actively encourage applications from individuals of all genders, ethnicities, abilities, and experiences. Weare aDisability Confident: Committedemployer andwant to ensure that everyone can apply and be part of our recruitment processes and sowe'llmake reasonable adjustments if you need them - just let us know when you apply. If you needassistancewith applying (i.e., would like to apply by phone or post) please email: Find out more about life at the Crick. What will you receive? At the Francis Crick Institute, we value our team members and are proud to offer an extensive range of benefits to support their well-being and development: Visas: Applicants for this role will be eligible for sponsorship to work in the UK Generous Leave: 28 days of annual leave, plus three additional days over Christmas and bank holidays. Pension Scheme: Defined contribution pension with employer contributions of up to 16%. Health & Well-being: 24/7 GP consultation services. Occupational health services and mental health support programs. Eye care vouchers and discounted healthcare plans. Work-Life Balance: Back-up care for dependents. Childcare support allowance. Annual leave purchase options. Crick Networks offering diverse groups' support, community and inclusive social events. Perks: Discounted gym memberships, bike-to-work scheme, and shopping discounts. Subsidised on-site restaurant and social spaces for team interaction. Please note you must meet the essential criteria listed within the Role Profile, to have your application reviewed. We reserve the right to withdraw this advert at any given time due to the number of applications received. About Us The Francis Crick Institute is a biomedical discovery institute researching the biology underlying human health. At the Crick, scientists and staff collaborate to stretch the very limits of what we know about how life works. Our work is helping to understand why disease develops and to translate discoveries into new ways to prevent, diagnose and treat illnesses such as cancer, heart disease, stroke, infections and neurodegenerative diseases. The Francis Crick Institute is a charity, founded by the Medical Research Council, Cancer Research UK, Wellcome, UCL (University College London), Imperial College London and King's College London.
Francis Crick Institute Ltd
Executive Assistant - CEO page is loaded Executive Assistant - CEO Apply locations London time type Full time posted on Posted 7 Days Ago job requisition id R2340 Salary for this Role: From £54,000 with benefits, subject to skills and experience Job Title: Executive Assistant - CEO Reports to: Edith Heard C Closing Date: 31/Jul/.59 GMT Job Description: Executive Assistant to the CEO - The Francis Crick Institute London, UK Are you a career Executive Assistant who thrives under pressure, delivers with precision, and builds trusted relationships at the highest level? This is an exciting opportunity to support Professor Edith Heard as she steps into the role of Director and CEO of the Francis Crick Institute, succeeding Nobel Laureate Sir Paul Nurse. We are seeking a highly accomplished and exceptional Executive Assistant to play a key role in supporting her leadership as she shapes the next chapter of the Crick's remarkable journey. As Executive Assistant to the Director, you'll play a pivotal role at the very heart of one of the world's leading scientific institutions. You'll operate in a fast-paced, high-profile environment, acting as the Director's trusted advisor, right hand and strategic operator. You'll bring extensive experience supporting senior, high-profile individuals at C-suite level within complex, high-profile organisations and manage a demanding schedule, coordinating national and international engagements. You'll be an exceptional communicator, skilled at managing a broad range of diverse senior stakeholders and building credibility and trust, liaising confidently with everyone from Nobel Prize-winning scientists and global research leaders to government ministers, major funders, and royalty. To succeed in this role, you'll need exceptional organisational skills, sound judgement, and the confidence to build trusted relationships at the highest level. Calm under pressure and able to anticipate needs, you'll bring clarity, discretion and drive to everything you do. You will ensure the smooth and effective running of the Director's office, and help to deliver the Crick's bold mission to drive benefits for human health. What you will be doing Coordinating the Director's complex and dynamic calendar, maintaining oversight of all priorities and commitments and ensuring optimal alignment of internal and external obligations. Ensuring the Director is optimally prepared for all meetings and other events, providing all documentation, briefings etc. in a timely manner, and providing effective follow up. Proactively managing the Director's high volume email inbox, ensuring timely responses, appropriate delegation and effective prioritisation of critical communications. Drafting, editing and managing high level correspondence, reports and presentations. Acting as a 'gatekeeper' in communications with global science leaders, institutional partners, government agencies and philanthropic stakeholders. Acting as the Director's 'eyes and ears', ensuring that all relevant matters are brought to the Director's attention and presented in the most appropriate and informative way. Liaising and building effective working relationships with Board members, including the Chairman, and their offices. Handling confidential information with the upmost integrity and discretion. What you will bring Extensive executive support experience with at least 5 years supporting a C-suite or equivalent senior leader in a complex, high-profile organisation. Outstanding organisational and problem-solving skills, with a demonstrated ability to think strategically, anticipate challenges, and offer proactive solutions. First class communication skills with experience of drafting clear and concise briefings, reports and other types of communication for a wide range of audiences, including senior management. Exhibiting the gravitas and professionalism to act on behalf of the Director with both internal and external stakeholders. Outstanding inter-personal skills and strong emotional intelligence with the ability to interact effectively with colleagues at all levels within the institute, displaying gravitas and able to offer advice, guidance and challenge where necessary. Resilient with an aptitude for, and enjoyment of, a dynamic, high workload. Capable of thriving in a high-pressure environment while maintaining professionalism and composure. High level of integrity, with the ability to handle confidential and sensitive information discreetly. A background in a scientific, academic or research environment is helpful, but not essential. What matters most is your resilience, professionalism, and ability to support a leader operating at the pinnacle of global science. For a full job description see here. About Working at the Crick Our values Everyone who works at the Crick has a valuable role to play in advancing the Crick's mission and shaping our culture. We arebold. We make space for creative, dynamic and imaginative ideas and approaches. We're not afraid to do things differently. We areopen. We're highly collaborative and interactive, and make sure our activities are visible to the outside world. We arecollegial. We show respect for one another, work cooperatively and support the wider community. At the Francis Crick Institute, we believe that diversity and inclusion are essential to driving innovation and scientific discovery. We are committed to creating a workplace where everyone feels valued, respected, and empowered to succeed, regardless of their background, identity, or personal circumstances. We actively encourage applications from individuals of all genders, ethnicities, abilities, and experiences. As a Disability Confident Leader, we ensure that everyone can apply and be part of our recruitment processes and so we'll make reasonable adjustments if you need them. For this or any other assistance you need with applying please email: Please note you must meet the essential criteria listed within the Role Profile, to have your application reviewed. We reserve the right to withdraw this advert at any given time due to the number of applications received. To find out more about life at the Crick click here . What will you receive? At the Francis Crick Institute, we value our team members and are proud to offer an extensive range of benefits to support their well-being and development: Generous Leave: 28 days of annual leave, plus three additional days over Christmas and bank holidays. Pension Scheme: Defined contribution pension with employer contributions of up to 16%. 24/7 GP consultation services. Occupational health services and mental health support programs. Eye care vouchers and discounted healthcare plans. Work-Life Balance: Back-up care for dependents. Childcare support allowance. Annual leave purchase options. Crick Networks offering diverse groups' support, community and inclusive social events. Discounted gym memberships, bike-to-work scheme, and shopping discounts. Subsidised on-site restaurant and social spaces for team interaction. Development & Recognition: Comprehensive training, mentoring About Us The Francis Crick Institute is a biomedical discovery institute researching the biology underlying human health. At the Crick, scientists and staff collaborate to stretch the very limits of what we know about how life works. Our work is helping to understand why disease develops and to translate discoveries into new ways to prevent, diagnose and treat illnesses such as cancer, heart disease, stroke, infections and neurodegenerative diseases. The Francis Crick Institute is a charity, founded by the Medical Research Council, Cancer Research UK, Wellcome, UCL (University College London), Imperial College London and King's College London.
Executive Assistant - CEO page is loaded Executive Assistant - CEO Apply locations London time type Full time posted on Posted 7 Days Ago job requisition id R2340 Salary for this Role: From £54,000 with benefits, subject to skills and experience Job Title: Executive Assistant - CEO Reports to: Edith Heard C Closing Date: 31/Jul/.59 GMT Job Description: Executive Assistant to the CEO - The Francis Crick Institute London, UK Are you a career Executive Assistant who thrives under pressure, delivers with precision, and builds trusted relationships at the highest level? This is an exciting opportunity to support Professor Edith Heard as she steps into the role of Director and CEO of the Francis Crick Institute, succeeding Nobel Laureate Sir Paul Nurse. We are seeking a highly accomplished and exceptional Executive Assistant to play a key role in supporting her leadership as she shapes the next chapter of the Crick's remarkable journey. As Executive Assistant to the Director, you'll play a pivotal role at the very heart of one of the world's leading scientific institutions. You'll operate in a fast-paced, high-profile environment, acting as the Director's trusted advisor, right hand and strategic operator. You'll bring extensive experience supporting senior, high-profile individuals at C-suite level within complex, high-profile organisations and manage a demanding schedule, coordinating national and international engagements. You'll be an exceptional communicator, skilled at managing a broad range of diverse senior stakeholders and building credibility and trust, liaising confidently with everyone from Nobel Prize-winning scientists and global research leaders to government ministers, major funders, and royalty. To succeed in this role, you'll need exceptional organisational skills, sound judgement, and the confidence to build trusted relationships at the highest level. Calm under pressure and able to anticipate needs, you'll bring clarity, discretion and drive to everything you do. You will ensure the smooth and effective running of the Director's office, and help to deliver the Crick's bold mission to drive benefits for human health. What you will be doing Coordinating the Director's complex and dynamic calendar, maintaining oversight of all priorities and commitments and ensuring optimal alignment of internal and external obligations. Ensuring the Director is optimally prepared for all meetings and other events, providing all documentation, briefings etc. in a timely manner, and providing effective follow up. Proactively managing the Director's high volume email inbox, ensuring timely responses, appropriate delegation and effective prioritisation of critical communications. Drafting, editing and managing high level correspondence, reports and presentations. Acting as a 'gatekeeper' in communications with global science leaders, institutional partners, government agencies and philanthropic stakeholders. Acting as the Director's 'eyes and ears', ensuring that all relevant matters are brought to the Director's attention and presented in the most appropriate and informative way. Liaising and building effective working relationships with Board members, including the Chairman, and their offices. Handling confidential information with the upmost integrity and discretion. What you will bring Extensive executive support experience with at least 5 years supporting a C-suite or equivalent senior leader in a complex, high-profile organisation. Outstanding organisational and problem-solving skills, with a demonstrated ability to think strategically, anticipate challenges, and offer proactive solutions. First class communication skills with experience of drafting clear and concise briefings, reports and other types of communication for a wide range of audiences, including senior management. Exhibiting the gravitas and professionalism to act on behalf of the Director with both internal and external stakeholders. Outstanding inter-personal skills and strong emotional intelligence with the ability to interact effectively with colleagues at all levels within the institute, displaying gravitas and able to offer advice, guidance and challenge where necessary. Resilient with an aptitude for, and enjoyment of, a dynamic, high workload. Capable of thriving in a high-pressure environment while maintaining professionalism and composure. High level of integrity, with the ability to handle confidential and sensitive information discreetly. A background in a scientific, academic or research environment is helpful, but not essential. What matters most is your resilience, professionalism, and ability to support a leader operating at the pinnacle of global science. For a full job description see here. About Working at the Crick Our values Everyone who works at the Crick has a valuable role to play in advancing the Crick's mission and shaping our culture. We arebold. We make space for creative, dynamic and imaginative ideas and approaches. We're not afraid to do things differently. We areopen. We're highly collaborative and interactive, and make sure our activities are visible to the outside world. We arecollegial. We show respect for one another, work cooperatively and support the wider community. At the Francis Crick Institute, we believe that diversity and inclusion are essential to driving innovation and scientific discovery. We are committed to creating a workplace where everyone feels valued, respected, and empowered to succeed, regardless of their background, identity, or personal circumstances. We actively encourage applications from individuals of all genders, ethnicities, abilities, and experiences. As a Disability Confident Leader, we ensure that everyone can apply and be part of our recruitment processes and so we'll make reasonable adjustments if you need them. For this or any other assistance you need with applying please email: Please note you must meet the essential criteria listed within the Role Profile, to have your application reviewed. We reserve the right to withdraw this advert at any given time due to the number of applications received. To find out more about life at the Crick click here . What will you receive? At the Francis Crick Institute, we value our team members and are proud to offer an extensive range of benefits to support their well-being and development: Generous Leave: 28 days of annual leave, plus three additional days over Christmas and bank holidays. Pension Scheme: Defined contribution pension with employer contributions of up to 16%. 24/7 GP consultation services. Occupational health services and mental health support programs. Eye care vouchers and discounted healthcare plans. Work-Life Balance: Back-up care for dependents. Childcare support allowance. Annual leave purchase options. Crick Networks offering diverse groups' support, community and inclusive social events. Discounted gym memberships, bike-to-work scheme, and shopping discounts. Subsidised on-site restaurant and social spaces for team interaction. Development & Recognition: Comprehensive training, mentoring About Us The Francis Crick Institute is a biomedical discovery institute researching the biology underlying human health. At the Crick, scientists and staff collaborate to stretch the very limits of what we know about how life works. Our work is helping to understand why disease develops and to translate discoveries into new ways to prevent, diagnose and treat illnesses such as cancer, heart disease, stroke, infections and neurodegenerative diseases. The Francis Crick Institute is a charity, founded by the Medical Research Council, Cancer Research UK, Wellcome, UCL (University College London), Imperial College London and King's College London.
Francis Crick Institute Ltd
Postdoctoral Project Research Scientist page is loaded Postdoctoral Project Research Scientist Apply locations London posted on Posted 21 Days Ago job requisition id R1944 Salary for this Role: £ 45,500 per annum s ubject to skills and experience, with benefits Job Title: Postdoctoral Project Research Scientist Reports to: Sila Ultanir Closing Date: 03/Aug/.59 GMT Job Description: Postdoctoral Project Research Scientist - Ultanir Lab (Francis Crick Institute) & Isalan Lab (Imperial College London) About us The Francis Crick Institute is Europe's largest biomedical research institute under one roof. Our world-class scientists and staff collaborate on vital research to help prevent, diagnose and treat illnesses such as cancer, heart disease, infectious diseases and neurodegenerative conditions. The Crick is a place for collaboration, innovation and exploration across many disciplines. A space where the brightest minds can pursue big and bold ideas and discover answers to crucial scientific questions. We support them in a dynamic environment which fosters excellence with state-of-the-art infrastructure, cutting-edge facilities, and a creative and curious culture. We've removed traditional boundaries of departments, divisions and disciplines and instead have an open approach that supports every researcher. This gives us the freedom to take risks and carry out high-quality, pioneering research. Creating a space for discovery without boundaries helps us to turn our science into benefits for human health and the economy. About the role This role is a joint collaboration between Sila Ultanir at the Francis Crick Institute and Mark Isalan at Imperial. The Ultanir lab studies the roles of protein kinases in neuronal development and function. The Isalan lab has long worked on a zinc finger engineering platform for gene therapy (PMID ). We are recruiting a motivated postdoctoral scientist to join the labs of Kinases and Brain Development at the Francis Crick Institute, London, UK and Mark Isalan at Imperial College London . The postdoctoral scientist will run a translational project to develop zinc finger protein transactivators for treatment of a neurodevelopmental disorder. In this project, we aim to develop ZFPs which can upregulate CDKL2 mRNA expression and test if these can rescue molecular, cellular and behavioural defects in CDKL5 deficiency models. Postdoctoral researcher will generate and test zinc finger protein transactivators. They will then use CDKL5 knockout mouse models to determine if they can restore CDKL5-mediated functions at molecular and behavioural level. iPSC derived neurons of CDD models and proteomics will also be used to test rescue of phosphorylation substrates. Postdoctoral researcher will lead their own projects, contribute to other projects on a collaborative basis and help train PhD students. To see the full job description, click here. About you The post holder should embody and demonstrate our core Crick values: Bold; Open; Collegial Essential PhD in biology, biochemistry, neuroscience or a related discipline or in the final stages of PhD submission Good knowledge of molecular biology skills Experience in mass spectrometry Track record of writing papers as evidenced by publications or submitted manuscripts in referred journals Evidence of data presentation at scientific meetings Desirable but not essential Experience in research with iPSC derived neurons Experience in RNA sequencing Experience in neonatal brain injections or in utero electroporation Experience in mouse behavioural analysis To see more about the lab, click here . About Working at the Crick Our values Everyone who works at the Crick has a valuable role to play in advancing the Crick's mission and shaping our culture! We arebold. We make space for creative, dynamic and imaginative ideas and approaches. We're not afraid to do things differently. We areopen. We're highly collaborative and interactive, and make sure our activities are visible to the outside world. We arecollegial. We show respect for one another, work cooperatively and support the wider community. At the Francis Crick Institute, we believe that diversity and inclusion are essential to driving innovation and scientific discovery. We are committed to creating a workplace where everyone feels valued, respected, and empowered to succeed, regardless of their background, identity, or personal circumstances. We actively encourage applications from individuals of all genders, ethnicities, abilities, and experiences. We want to ensure that everyone can apply and be part of our recruitment processes and so we'll make reasonable adjustments if you need them - just let us know when you apply. If you need assistance with applying (i.e., would like to apply by phone or post)please email: To find out more about life at the Crick click here . What will you receive? At the Francis Crick Institute, we value our team members and are proud to offer an extensive range of benefits to support their well-being and development: Visas: Applicants for this role will be eligible for sponsorship to work in the UK Generous Leave: 28 days of annual leave, plus three additional days over Christmas and bank holidays. Pension Scheme: Defined contribution pension with employer contributions of up to 16%. Health & Well-being: 24/7 GP consultation services. Occupational health services and mental health support programs. Eye care vouchers and discounted healthcare plans. Work-Life Balance: Back-up care for dependents. Childcare support allowance. Annual leave purchase options. Perks: Discounted gym memberships, bike-to-work scheme, and shopping discounts. Subsidised on-site restaurant and social spaces for team interaction.
Postdoctoral Project Research Scientist page is loaded Postdoctoral Project Research Scientist Apply locations London posted on Posted 21 Days Ago job requisition id R1944 Salary for this Role: £ 45,500 per annum s ubject to skills and experience, with benefits Job Title: Postdoctoral Project Research Scientist Reports to: Sila Ultanir Closing Date: 03/Aug/.59 GMT Job Description: Postdoctoral Project Research Scientist - Ultanir Lab (Francis Crick Institute) & Isalan Lab (Imperial College London) About us The Francis Crick Institute is Europe's largest biomedical research institute under one roof. Our world-class scientists and staff collaborate on vital research to help prevent, diagnose and treat illnesses such as cancer, heart disease, infectious diseases and neurodegenerative conditions. The Crick is a place for collaboration, innovation and exploration across many disciplines. A space where the brightest minds can pursue big and bold ideas and discover answers to crucial scientific questions. We support them in a dynamic environment which fosters excellence with state-of-the-art infrastructure, cutting-edge facilities, and a creative and curious culture. We've removed traditional boundaries of departments, divisions and disciplines and instead have an open approach that supports every researcher. This gives us the freedom to take risks and carry out high-quality, pioneering research. Creating a space for discovery without boundaries helps us to turn our science into benefits for human health and the economy. About the role This role is a joint collaboration between Sila Ultanir at the Francis Crick Institute and Mark Isalan at Imperial. The Ultanir lab studies the roles of protein kinases in neuronal development and function. The Isalan lab has long worked on a zinc finger engineering platform for gene therapy (PMID ). We are recruiting a motivated postdoctoral scientist to join the labs of Kinases and Brain Development at the Francis Crick Institute, London, UK and Mark Isalan at Imperial College London . The postdoctoral scientist will run a translational project to develop zinc finger protein transactivators for treatment of a neurodevelopmental disorder. In this project, we aim to develop ZFPs which can upregulate CDKL2 mRNA expression and test if these can rescue molecular, cellular and behavioural defects in CDKL5 deficiency models. Postdoctoral researcher will generate and test zinc finger protein transactivators. They will then use CDKL5 knockout mouse models to determine if they can restore CDKL5-mediated functions at molecular and behavioural level. iPSC derived neurons of CDD models and proteomics will also be used to test rescue of phosphorylation substrates. Postdoctoral researcher will lead their own projects, contribute to other projects on a collaborative basis and help train PhD students. To see the full job description, click here. About you The post holder should embody and demonstrate our core Crick values: Bold; Open; Collegial Essential PhD in biology, biochemistry, neuroscience or a related discipline or in the final stages of PhD submission Good knowledge of molecular biology skills Experience in mass spectrometry Track record of writing papers as evidenced by publications or submitted manuscripts in referred journals Evidence of data presentation at scientific meetings Desirable but not essential Experience in research with iPSC derived neurons Experience in RNA sequencing Experience in neonatal brain injections or in utero electroporation Experience in mouse behavioural analysis To see more about the lab, click here . About Working at the Crick Our values Everyone who works at the Crick has a valuable role to play in advancing the Crick's mission and shaping our culture! We arebold. We make space for creative, dynamic and imaginative ideas and approaches. We're not afraid to do things differently. We areopen. We're highly collaborative and interactive, and make sure our activities are visible to the outside world. We arecollegial. We show respect for one another, work cooperatively and support the wider community. At the Francis Crick Institute, we believe that diversity and inclusion are essential to driving innovation and scientific discovery. We are committed to creating a workplace where everyone feels valued, respected, and empowered to succeed, regardless of their background, identity, or personal circumstances. We actively encourage applications from individuals of all genders, ethnicities, abilities, and experiences. We want to ensure that everyone can apply and be part of our recruitment processes and so we'll make reasonable adjustments if you need them - just let us know when you apply. If you need assistance with applying (i.e., would like to apply by phone or post)please email: To find out more about life at the Crick click here . What will you receive? At the Francis Crick Institute, we value our team members and are proud to offer an extensive range of benefits to support their well-being and development: Visas: Applicants for this role will be eligible for sponsorship to work in the UK Generous Leave: 28 days of annual leave, plus three additional days over Christmas and bank holidays. Pension Scheme: Defined contribution pension with employer contributions of up to 16%. Health & Well-being: 24/7 GP consultation services. Occupational health services and mental health support programs. Eye care vouchers and discounted healthcare plans. Work-Life Balance: Back-up care for dependents. Childcare support allowance. Annual leave purchase options. Perks: Discounted gym memberships, bike-to-work scheme, and shopping discounts. Subsidised on-site restaurant and social spaces for team interaction.